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Gonzalez Tendero A A Hospital Clinic, IDIBAPS, Department of Maternal-Fetal Medicine, Barcelona, - - 2014
While cardiomyocytes have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a complex cell organisation in a 3D fibre structure. Such information is essential to understand diseases. CT/MRI provide structural information, however, their resolution is too low to study cellular mechanics in detail. Microscopy ...
Iaccarino D D University of Padova, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Padua, - - 2014
The gene Coiled Coil Domain Containing 80 (Ccdc80) is highly expressed in the hearts of vertebrates and its role is well defined in tumor suppression, glucose homeostasis and adipocyte differentiation. Our aims are to define its functional role during embryonic development and in cardiomyopathies. We used 3 different models: 1. ...
Ciccarelli M M University of Salerno, Salerno, - - 2014
Heart Failure (HF) is a complex disease characterized by progressive cardiac dilation and loss of ATP content needed to accomplish myocardial contractile function. GRK2 is a serine/threonine kinase that phosphorylates and binds receptors coupled to G proteins, such as β-adrenergic receptors (βAR) and it is involved in the pathophysiology of ...
Nemeth Z Z University of Pecs, Medical School, Pathophysiology and Gerontology, and Szentagothai Research Centre, Pecs, - - 2014
Pericardial fluid (PF) contains biologically active substances, such as the L-arginine and its methylated derivative asymmetric dimethylarginine (ADMA). L-arginine is the substrate of nitric oxide synthase (NOS) producing NO, which has been implicated in cardiac remodeling, whereas ADMA interferes with NO bioavailability. Thus we hypothesized that L-arginine and ADMA present ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The importance of apoptosis in cell death following ischemia and reperfusion has been demonstrated in vivo rodent modelsA potential strategy to alleviate cardiac I/Ri is to exploit the potent anti-inflammatory and cytoprotective effects of carbon monoxide (CO) by application of so-called CO-releasing molecules (CORMs). Here, we assessed whether CO released ...
Horckmans M M Ludwig-Maximilians University, Institute for Cardiovascular Prevention (IPEK), Munich, - - 2014
Neutrophils contribute to tissue damage after acute myocardial ischemia and reperfusion, but their role in infarct healing is less well understood. Because neutrophil-derived granule proteins mediate classical monocyte recruitment in acute inflammation, we hypothesized that neutrophil depletion during the acute inflammatory phase will improve infarct healing by reducing the proinflammatory ...
Lip Gregory Yh GY City Hospital, Birmingham, United Kingdom & Aalborg University, Aalborg, Denmark - - 2014
Advances in pharmacological and devices therapy have greatly improved prognosis in patients with systolic heart failure. Despite this congestive heart failure still bears a very grim prognosis, particularly in patients with more advances stages of the disease that are so frequently seen on hospital wards. Which pathogenic pathways may need ...
Gorjup Vojka V Vojka Gorjup, Marko Noc, Peter Radsel, Department of Intensive Internal Medicine, University Medical Center Ljubljana, 1000 Ljubljana, - - 2014
Coronary artery disease is the most frequent cause of sudden cardiac death. There is general consensus that immediate coronary angiography with percutaneous coronary intervention (PCI) should be performed in all conscious and unconscious patients with ST-elevation myocardial infarction in post-resuscitation electrocardiogram. In these patients acute coronary thrombotic lesion ("ACS" lesion) ...
Lima-Leopoldo Ana Paula AP Federal University of Espirito Santo - - 2014
Few studies have evaluated the relationship between the duration of obesity, cardiac function and the proteins involved in myocardial calcium (Ca(2+)) handling. We hypothesized that long-term obesity promotes cardiac dysfunction due to a reduction of expression and/or phosphorylation of myocardial Ca(2+)-handling proteins. Thirty-day-old male Wistar rats were distributed into two ...
Stallone Fabio F Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland Department of Cardiology, University Hospital Basel, Basel, - - 2014
Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. A total of 984 ...
Malfitano Christiane C Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, - - 2014
While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease (IHD), animal data have so far pointed to a lower probability of IHD. Thus, the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned ...
Peng Ying Y UW-Madison, United - - 2014
Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often precipitated by myocardial infarction (MI). However, the molecular changes driving cardiac dysfunction immediately after MI remain poorly understood. Myofilament proteins, responsible for cardiac contraction and relaxation, play critical roles in signal reception and transduction ...
Cervellin Gianfranco G Emergency Department, Academic Hospital of Parma, Parma, - - 2014
The history of myocardial infarction (MI) diagnostics has gone through a continuous evolution over the past century, when several new discoveries have contributed to remarkably increase the number of patients appropriately diagnosed with this condition. The tale "of MIs and Men" displays rather a long history, since atherosclerosis was found ...
Ferrari Roberto R Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy - - 2014
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that ...
Boopathy Archana V AV Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown promising outcomes. Notch1 signaling plays a critical role in cardiac development and in the survival, cardiogenic lineage commitment, and differentiation of cardiac stem/progenitor cells. In this study, we functionalized ...
Zhao Zhi-Gang ZG Intensive Care Unit, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, - - 2014
Embelin has been used to treat fever and inflammatory diseases for thousands of years. Although reports indicate that embelin has antiinflammatory effects, its effects on myocardial injury following cardiac arrest (CA) have not been previously explored. In this study, we aim to investigate the protective effects of embelin on myocardial ...
Ganapathi Asvin M AM Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, - - 2014
Patients with thoracic aortic disease undergoing thoracic endovascular aortic repair (TEVAR) often have concomitant coronary artery disease and are at risk for perioperative adverse cardiac events. Despite this risk, the need for and extent of preoperative cardiac workup before TEVAR remain undefined. This study seeks to assess the adequacy of a ...
de Waha Suzanne - - 2014
This study aimed to evaluate the incremental prognostic value of infarct size, microvascular obstruction (MO), myocardial salvage index (MSI), and left ventricular ejection fraction (LV-EFCMR) assessed by cardiac magnetic resonance imaging (CMR) in comparison to traditional outcome markers in patients with ST-elevation myocardial infarction (STEMI) reperfused by primary percutaneous intervention ...
Karmali Kunal N KN Departments of Preventive Medicine and Medicine (Cardiology), Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, USA, - - 2014
Cardiac rehabilitation is an important component of recovery from coronary events but uptake and adherence to such programs are below recommended levels. In 2010, our Cochrane review identified some evidence that interventions to increase uptake of cardiac rehabilitation can be effective but there was insufficient evidence to provide recommendations on ...
Prunet Bertrand - - 2014
Although aneurysmal subarachnoid hemorrhage (SAH) is often complicated by myocardial injury, whether this neurogenic cardiomyopathy is associated with the modification of cardiac metabolism is unknown. This study sought to explore, by positron emission tomography/computed tomography, the presence of altered cardiac glucose metabolism after SAH. During a 16-month period, 30 SAH ...
Varvarousi Giolanda G University of Athens, Medical School, Greece, 75 Mikras Asias street, 11527, Athens, - - 2014
Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent benefits for long-term survival or favourable neurologic outcome. Levosimendan ...
Taggart Peter P The Heart Hospital, University College London, UK. Electronic address: - - 2014
Understanding the mechanisms of fatal ventricular arrhythmias is of great importance. In view of the many electrophysiological differences that exist between animal species and humans, the acquisition of basic electrophysiological data in the intact human heart is essential to drive and complement experimental work in animal and in-silico models. Over ...
Hatam Nima - - 2014
Disturbances of interatrial conduction have been proposed as one of the contributing mechanisms of postoperative atrial fibrillation (AF). P-wave dispersion has been recognized as a sensitive tool for detecting interatrial conduction disturbances. Doppler myocardial imaging (DMI) has been validated as a non-invasive tool to indirectly reflect electrical atrial activation and ...
Gournay Véronique V CHU de Nantes, Service de Cardiologie Pédiatrique, Nantes, France. Electronic address: - - 2014
The number of children in need of mechanical circulatory support has increased substantially over the last two decades, due to the technological progress made in surgery and intensive care, leading to improved survival of patients with congenital heart disease. In addition, primary myocardial dysfunction related to myocarditis or dilated cardiomyopathy ...
Hatipoglu Suzan S Department of Cardiology, Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey, - - 2014
In the absence of mitral valve disease left atrial (LA) volume is a marker of diastolic dysfunction and its severity. This study investigated the relationship between left ventricular (LV) end diastolic pressure (LVEDP) and LA volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (RT3DE), in a ...
Zhang Yixuan Y UCLA, United - - 2014
Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked upregulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation (AF), which is accompanied by overproduction of reactive oxygen species (ROS). In the present study we investigated impact ...
Vecchiati Alessandra A Alessandra Vecchiati, Sara Tellatin, Annalisa Angelini, Sabino Iliceto, Francesco Tona, Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, 35128 Padova, - - 2014
Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy (CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening ...
Umoh Nsini A NA Department of Physiology & Biophysics, College of Medicine, Howard University, Washington, District of - - 2014
Clinical manifestations of alcohol abuse on the cardiac muscle include defective contractility with the development of heart failure. Interestingly, low alcohol consumption has been associated with reduced risk of cardiovascular disease. Although several hypotheses have been postulated for alcoholic cardiomyopathy and for the low-dose beneficial cardiovascular effects, the precise mechanisms ...
Borlaug Barry A BA The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, - - 2014
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials ...
Myers J A JA Triangle Veterinary Referral Hospital, Raleigh, - - 2014
Information regarding cardiac changes in domestic cats with acromegaly is limited. The objective of this study was to describe the echocardiographic findings in cats with acromegaly. Eighteen cats diagnosed with acromegaly at Colorado State University between 2008 and 2012. Of these 18 cats, 11 had echocardiography performed. A retrospective review ...
Shigeru Mayumi M aDepartment of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine bKobe University Graduate School of Health Sciences, Kobe cHyogo Brain and Heart Center, Himeji, - - 2014
A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between Tc-tetrofosmin (Tc-TF) myocardial scintigraphy and the response to CRT. Twenty-one patients ...
Liu Xiaoyu X From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.); and Institute of Molecular Medicine, Peking University, Beijing, China - - 2014
Studies have reported that development of congestive heart failure is associated with increased endoplasmic reticulum stress. Double stranded RNA-activated protein kinase R-like endoplasmic reticulum kinase (PERK) is a major transducer of the endoplasmic reticulum stress response and directly phosphorylates eukaryotic initiation factor 2α, resulting in translational attenuation. However, the physiological ...
Hidestrand Pip M PM Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI, USA - - 2014
We present a patient with complex single ventricle physiology who was subsequently diagnosed with atresia of the coronary sinus ostium in the setting of myocardial dysfunction following operative palliation. Although a rare cardiac defect, awareness is important as the coronary venous system will often drain to a left superior vena ...
Zong Nobel N The NHLBI Proteomics Center at UCLA; Departments of Physiology and Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2014
Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets poly-ubiquitinated proteins for destruction, it itself is modifiable by ubiquitination. We aim to identify the exact ubiquitination sites on cardiac proteasomes and examine whether they are also subject to acetylations. Assembled cardiac 20S proteasome complexes were purified from ...
Gupta Saurabh Kumar SK Department of Cardiology, All India Institute of Medical Sciences, New Delhi, - - 2014
Atrial inversion (or mirror-imaged atrial arrangement) occurring in isolation, that is, without corresponding mirror imagery of the viscera, has been previously shown with discordant atrioventricular connections resulting in transposition physiology. We hereby report a case of "isolated atrial inversion" wherein atrioventricular connections were concordant owing to the presence of criss-crossing ...
Arking Dan E DE 1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. - - 2014
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to ...
Waksmonski Carol A CA Columbia University Medical Center, 630 West 168th St, New York, NY 10032. Electronic address: - - 2014
There are multiple imaging modalities available for the assessment of pregnant women with known or suspected cardiac disease. Because of its safety and general availability, echocardiography is the preferred study of choice for the evaluation of ventricular function, valvular heart disease, congenital heart disease, evaluation of the aorta, and the ...
Chowdhury Arpita A Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, - - 2014
The cardiac extracellular matrix (ECM) undergoes a dynamic transition following myocardial infarction. Fibulin-6, an ECM protein is expressed in cell junctions particularly in tissues subjected to significant mechanical stress. Fibulin-6 deficiency results in defective cell migration in nematodes and early embryonic lethality in mice. The role of fibulin-6 in healthy ...
Rordorf Roberto R Department of Cardiology, IRCCS Fondazione Policlinico S. - - 2014
Background:Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated whether pro-inflammatory cytokines might predict the response to cardiac resynchronization therapy (CRT).Methods and Results:Plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 were assessed in 91 patients before CRT. Response to CRT was defined ...
Cai Benzhi B Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, - - 2014
Our in vitro studies revealed that a transcription factor, Forkhead box protein O1 (FoxO1), negatively regulates the expression of NaV1.5, a main α subunit of the cardiac Na(+) channel, by altering the promoter activity of SCN5a in HL-1 cardiomyocytes. The in vivo role of FoxO1 in the regulation of cardiac ...
Wang Lina L Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, - - 2014
Studies from our group and others have indicated that paracrine function is one of major mechanisms underlying stem cell-mediated cardioprotection. To improve therapeutic efficacy of cardiac stem cells (CSCs), modification of CSCs to enhance their paracrine actions is of great interest. We have shown previously that stem cells from female ...
Al Mohani Ghaliah G Arrhythmology and Electrophysiology, Centro Cardiologico Monzino, IRCCS, Via C Parea n. 4, 20138, Milan, Italy, - - 2014
Electrical storm (ES) is one of the most challenging clinical scenarios facing electrophysiologists, and in certain settings emergency ablation should be performed. The majority of ES occurs in patients with structural heart disease, predominantly coronary heart disease and nonischemic heart disease like right ventricular arrhythmogenic dysplasia and previous myocarditis as ...
Yasui Haruyo H Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, - - 2014
Engineering of three-dimensional (3D) cardiac tissues using decellularized extracellular matrix could be a new technique to create an "organ-like" structure of the heart. To engineer artificial hearts functionally comparable to native hearts, however, much remain to be solved including stable excitation-propagation. To elucidate the points, we examined conduction properties of ...
Moon Jeonggeun J Division of Cardiology, Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Republic of - - 2014
Objectives: To identify differences in cardiac hemodynamic changes between the Valsalva maneuver and nitroglycerin (NTG) administration. Methods: Fifty-three subjects (37 men, 43 ± 12 years) with normal cardiac function [left ventricular ejection fraction ≥55%, early to late mitral inflow velocity ratio (E/A) ≥1, left atrial volume index ≤34 ml/m(2) and ...
Armenian Saro H SH Population Sciences, City of Hope - - 2014
Purpose: To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. Experimental Design: Using a ...
Czompa Attila A Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, - - 2014
Cardiovascular diseases are primary cause of death worldwide, particularly among populations with sedentary lifestyles and diets rich in animal products and processed foods. Currently, public health countermeasures to these disorders focus on costly and often marginally effective interventions administered only after the development of disease. These countermeasures are mainly palliative ...
Ito Kohei K Department of Biological Information, Tokyo Institute of Technology, Yokohama, - - 2014
Background: Zebrafish have the ability for heart regeneration. However, another teleost animal model, the medaka, had not yet been investigated for this capacity. Results: Compared with zebrafish, the medaka heart responded differently to an injury: An excessive fibrotic response occurred in the medaka heart; and existing cardiomyocytes or cardiac progenitor ...
Boudoulas Konstantinos Dean KD Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, - - 2014
Studies of left atrial (LA) function, until the latter part of the 20th century, were mostly limited to experimental animal models and to studies related to clinical research in the cardiac catheterization laboratory. For this reason, LA function has received considerably less attention than left ventricular (LV) functions, even though ...
Zhao Lei L Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Rd Beijing, - - 2014
To evaluate the accuracy of multidetector computed tomography (MDCT) in assessing myocardial delayed enhancement and left ventricle wall thickness in hypertrophic cardiomyopathy (HCM) compared with cardiac magnetic resonance (CMR) as the reference standard. Eighty consecutive patients (59 male; 53.2±13.0 years) were examined with MDCT, followed by CMR 1 day later. ...
Liu Chia-Ying CY Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, - - 2014
Cardiac magnetic resonance (CMR) is a standard of reference for cardiac structure and function. Recent advances in T1 mapping and spectroscopy also provide assessment of myocardial tissue composition. However, the reference ranges of left ventricular parameters have rarely been assessed in an African-American (AA) population without known cardiac disease. To ...
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