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Results 301 - 350 of 7338
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Tuomainen Petri O PO Department of Internal Medicine and Heart Center, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finlandia; Department of Cardiology, Satakunta Central Hospital, Pori, - - 2014
We performed a pooled analysis based on patient-level data from the TITAX-AMI and BASE-ACS trials to evaluate the outcome of titanium-nitride-oxide-coated bioactive stents vs drug-eluting stents in patients with ST-segment elevation myocardial infarction at 2-year follow-up. The TITAX-AMI trial compared bioactive stents with paclitaxel-eluting stents in 425 patients with acute ...
García-Lunar Inés I Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España; Servicio de Cardiología, Hospital Universitario Quirón, Universidad Europea de Madrid, Madrid, España; Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, - - 2014
Cardiac resynchronization therapy is associated with improved quality of life and reduced morbidity and mortality in patients with severe ventricular dysfunction and wide QRS. However, its role in the reduction of ventricular arrhythmias is more controversial. We compared the incidence of ventricular arrhythmias in patients who were undergoing cardiac resynchronization ...
Tuomainen Petri O PO Department of Internal Medicine and Heart Center, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland; Department of Cardiology, Satakunta Central Hospital, Pori, - - 2014
We performed a pooled analysis based on patient-level data from the TITAX-AMI and BASE-ACS trials to evaluate the outcome of titanium-nitride-oxide-coated bioactive stents vs drug-eluting stents in patients with ST-segment elevation myocardial infarction at 2-year follow-up. The TITAX-AMI trial compared bioactive stents with paclitaxel-eluting stents in 425 patients with acute ...
Finsterer Josef J Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: - - 2014
Myosin-heavy-chain 7 (MYH7)-myopathy manifests clinically with a distal, scapuloperoneal, limb-girdle (proximal), or axial distribution and may involve the respiratory muscles. Cardiac involvement is frequent, ranging from relaxation impairment to severe dilative cardiomyopathy. Progression and earlier onset of cardiac disease in successive generations with MYH7-myopathy is unreported. In a five-generation family ...
Marcinkiewicz Anna - - 2014
Off-pump coronary artery bypass (OPCAB) surgery can be associated with some intrinsic, but relatively rare complications. A pericardial effusion is a common finding after cardiac surgeries, but the prevalence of a cardiac tamponade does not exceed 2% and is less frequent after myocardial revascularization.Authors believe that in our patient an ...
Pedrizzetti Gianni G Department of Engineering and Architecture, University of Trieste, Piazzale Europa, 1, 34127 Trieste, - - 2014
Blood motion in the heart features vortices that accompany the redirection of jet flows towards the outlet tracks. Vortices have a crucial role in fluid dynamics. The stability of cardiac vorticity is vital to the dynamic balance between rotating blood and myocardial tissue and to the development of cardiac dysfunction. ...
Lee AhYoung A Icahn School of Medicine at Mount Sinai, Cardiovascular Research Center, New York, New York, United States ; - - 2014
Small ubiquitin-like modifier type 1 (SUMO-1) has been shown to play a critical role in the dysfunction of the cardiac isoform of the sarcoplasmic reticulum calcium ATPase pump (SERCA2a) in the setting of heart failure. In cardiac hypertrophy, the role of SUMO-1 has not been defined and our study's goals ...
Manabe Osamu O Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Cardiac sarcoidosis is most commonly found in the left ventricular (LV) free wall. Presence in the right ventricle (RV) is less common but might be useful for detecting cardiac involvement of sarcoidosis. (18)F-fluorodeoxyglucose ((18)F-FDG) PET has been used to detect LV regions with cardiac sarcoidosis. However, the same has not ...
Nudi Francesco F Service of Nuclear Cardiology, Madonna della Fiducia Clinic, Via Cesare Correnti 6, 00179, Rome, Italy, - - 2014
Myocardial perfusion scintigraphy (MPS) represents a key prognostic tool, but its predictive yield is far from perfect. We developed a novel clinically relevant segmentation method and a corresponding maximal ischemia score (MIS) in order to risk-stratify patients undergoing MPS. Patients referred for MPS were identified, excluding those with evidence of ...
Sahin Irfan I Department of Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey - - 2014
Atrial fibrillation (AF) after cardiac surgery has been reported to be approximately 30%, making it one of the most important causes of morbidity and mortality post surgery. Although various clinical and laboratory predictors and underlying mechanisms progressing to postoperative AF have been proposed, the role of ischaemia in pathogenesis is ...
Mann Douglas L DL Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: - - 2014
Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.
Trolese Luca L Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, - - 2014
The choice of left ventricular pacing configurations (LVPCs) of quadripolar leads used for cardiac resynchronization therapy (CRT) affects haemodynamic response and thus may be a tool for device optimization. The value of surface electrocardiograms and interventricular time delays (IVDs) for optimization is unknown. Sixteen patients implanted with a CRT device ...
Neijts Melanie M Department of Biological Psychology, Vrije University (VU) Amsterdam, Amsterdam, The Netherlands; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The - - 2014
This study estimated the heritability of 24-h heart rate variability (HRV) measures, while considering ceiling effects on HRV at low heart rates during the night. HRV was indexed by the standard deviation of all valid interbeat intervals (SDNN), the root mean square of differences between valid, successive interbeat intervals (RMSSD), ...
Glaubitz Michael M ZIK-HIKE - Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen", University Medicine - - 2014
Background:Ventricular dilation is known as a pivotal predictor in recent-onset cardiomyopathy (ROCM), but its pathophysiology is not fully understood. In the present study we investigated whether single-cell stiffness of right and left ventricular-derived fibroblasts has an effect on cardiac phenotype in patients with ROCM.Methods and Results:Patients with endomyocardial biopsy-proven ROCM were included ...
Mohammed M I MI Heriot-Watt University, MIcroSystems Engineering Centre (MISEC), Research Institute of Signals, Sensors and Systems (ISSS), School of Engineering and Physical Sciences, Earl Mountbatten Building, Edinburgh, EH14 4AS Scotland, UK. Electronic address: - - 2014
Cardiovascular diseases are the most prevalent medical conditions affecting the modern world, reducing the quality of life for those affected and causing an ever increasing burden on clinical resources. Cardiac biomarkers are crucial in the diagnosis and management of patient outcomes. In that respect, such proteins are desirable to be ...
Kudo-Sakamoto Yoko Y Osaka University, - - 2014
Enzymatic proteolysis by calpains, Ca(2+)-dependent intracellular cysteine proteases, has been implicated in pathological processes such as cellular degeneration or death. Here, we investigated the role of calpain activation in the hearts subjected to myocardial infarction. We produced myocardial infarction in Cast(-/-) mice deficient for calpastatin, the specific endogenous inhibitory protein ...
Derval Nicolas N Hopital Cardiologique du Haut Lévêque, CHU Bordeaux, Pessac, - - 2014
Recent studies have demonstrated that LV pacing site is a critical parameter in optimizing cardiac resynchronization therapy (CRT). The present study evaluates the effect of pacing from different LV locations on QRS duration (QRSd) and their relationship to acute hemodynamic response in congestive heart failure (CHF) patients. Thirty-five patients with ...
Ghavami S - - 2014
Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of ...
Link Mark S MS The Cardiac Arrhythmia Center, Tufts Medical Center, 800 Washington Avenue, Boston, MA, 02111, USA, - - 2014
Commotio cordis is increasing described and it is now clear that this phenomenon is an important cause of sudden cardiac death on the playing field. Victims are predominantly young, male, and struck in the left chest with a ball. An animal model has been developed and utilized to explore the ...
Colombo Alessandro A Cardiology Division, European Institute of Oncology, I.R.C.C.S., Via Ripamonti 435, 20141, Milan, Italy, - - 2014
Both conventional and novel antineoplastic drugs may cause damage to the heart, ultimately affecting patients' survival and quality of life. In fact, the most frequent and typical clinical manifestation of cardiotoxicity, asymptomatic or symptomatic left ventricular dysfunction, may be induced not only by conventional cancer therapy, like anthracyclines, but also ...
Geri Guillaume G aMedical Intensive Care Unit bEmergency Department, Cochin Hospital, Assistance Publique-Hôpitaux de Paris cParis Descartes University dSudden Death Expertise Centre, Paris Cardiovascular Research Centre, INSERM U970 (team 4), Paris, - - 2014
Percutaneous coronary revascularization is the cornerstone treatment of acute coronary syndromes. Out-of-hospital cardiac arrest (OHCA) is in most cases related to a culprit coronary occlusion and should be treated as soon as possible. To date, no biomarker has been evidenced to correctly predict culprit coronary occlusion in OHCA patients in ...
Fagnoul David D aDepartment of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium bService de Réanimation Médicale, Groupe Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, - - 2014
To discuss the role of extracorporeal membrane oxygenation (ECMO) in patients with cardiac arrest. Return to spontaneous circulation dramatically decreases with the duration of cardiopulmonary resuscitation (CPR). In this context, it has been proposed to implement venoarterial ECMO in order to assist CPR (ECPR) both in inhospital cardiac arrest (IHCA) ...
Marzak Halim H aLaboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Faculté de Médecine, Fédération de Médecine translationnelle, Université et Centre Hospitalier de Strasbourg, Strasbourg bMouse Clinical Institute, Illkirch-Graffenstaden, - - 2014
Heart failure with preserved left-ventricular ejection fraction (HF-PEF) is an entity leading to pulmonary congestion because of impaired diastolic filling. This syndrome usually strikes those who have experienced a long history of hypertension or metabolic risk factors. Pathophysiological mechanisms are not fully understood, and standard therapy is not established. Relevant ...
Lupu Silvia S Cardiovascular Disease and Transplant Institute, University of Medicine and Pharmacy, Târgu Mureş, - - 2014
Left atrium enlargement is a pathophysiological response to volume and pressure overload associated with a wide range of cardiovascular disorders leading to left ventricle systolic and diastolic dysfunction. Physiological factors contribute to significant differences in left atrium size in normal individuals. Moreover, left atrium enlargement was shown to have a ...
Guarracino Fabio F From the *Department of Cardiothoracic Anesthesia and Intensive Care Medicine, Azienda Ospedaliero Universitaria Pisana; †Cardiac Thoracic and Vascular Department, University of Pisa, Pisa; and Departments of ‡Anesthesiology and Intensive Care, and §Cardiac Surgery, Università Vita-Salute San Raffaele, Milano, - - 2014
The percutaneous mitral valve (MV) repair procedure performed with the MitraClip delivery system is increasingly used to treat severe mitral regurgitation in high-risk patients. The treatment involves percutaneous insertion and positioning of a clip between the MV leaflets. Transesophageal echocardiography (TEE) plays a key role in the procedure by providing ...
Proclemer Alessandro A Division of Cardiology, University Hospital S. Maria della Misericordia, IRCAB Foundation Udine, Udine, Italy - - 2014
The purpose of this European Heart Rhythm Association (EHRA) survey was to examine the current practice on the choice of implantable cardioverter-defibrillator (ICD) type, use of defibrillation testing, and ICD programming for detection and therapy of ventricular arrhythmias. In accordance with recent guidelines and the results of observational studies, the ...
Francis Nataya N College of Nursing, University of South Florida in - - 2014
Fluorouracil (5-FU) is an antimetabolite that has become the cornerstone chemotherapeutic agent used to treat tumors of the gastrointestinal tract. Although proven to be effective, 5-FU can cause cardiotoxicity, which can be life-threatening. Adverse cardiac-related events induced by 5-FU include angina pectoris, myocardial infarction, supraventricular tachycardia, and atrial fibrillation. Nurses ...
Penciu Oana-Maria OM Department of Internal Medicine, Western Connecticut Health Network, Danbury Hospital, Danbury, - - 2014
Hypertrophic cardiomyopathy and anomalous origin of the coronary artery from the opposite sinus are common causes of sudden cardiac death. These entities have rarely been reported together. Here we present the case of a 48-year-old woman with hypertrophic cardiomyopathy and significant left ventricular outflow tract obstruction. She was referred for ...
Saxena Amit A The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx - - 2014
The CXC chemokine CXCL10 is upregulated in the infarcted myocardium and limits cardiac fibrosis by inhibiting growth factor-mediated fibroblast migration. CXCL10 signals by binding to its receptor CXCR3; however, recently CXCR3-independent CXCL10 actions have been suggested. Our study explores the role of CXCR3 signaling in myocardial infarction and investigates its ...
Ulusoy Sükrü S Karadeniz Technical - - 2014
Background-Kidney transplant is a most important replacement therapy. It reduces cardiovascular mortality and morbidity but does not fully correct impairments in cardiac function. Fragmented QRS (fQRS) complex includes various RSR' patterns with different QRS complex morphologies on electrocardiograms.Objective-To analyze fQRS frequency and the relationship between fQRS and left ventricular function ...
Webber Matthew M Royal Free - - 2014
Cardiac involvement is a well described complication in Systemic Sclerosis (SSc) and is considered to be one of the leading causes of mortality. Cardiac MRI (CMR) is an emerging tool that can add new information on fibrosis and inflammation. Its use in SSc is not well described and is limited ...
Dastidar Amardeep Ghosh AG Bristol Heart - - 2014
Non-traumatic out of hospital cardiac arrest (OOHCA) is one of the leading causes of death in western world. Acute coronary syndrome (ACS) is the most common aetiology of OOHCA with a culprit artery lesion identified on invasive angiography. However, 1/3rd of patients with OOHCA have unobstructed coronaries on angiography. Non-invasive ...
Ferreira Vanessa V University of - - 2014
Sudden and/or chronic exposure to catecholamines may predispose patients with phaeochromocytoma to cardiac pathology, including left ventricular (LV) hypertrophy, myocardial infarction, stress-induced cardiomyopathy and heart failure. This is a prospective, multicentre study using cardiovascular magnetic resonance (CMR) imaging to describe the variety and incidence of cardiac abnormalities in patients diagnosed ...
Patel Hitesh H NIHR Cardiovascular BRU, Royal Brompton - - 2014
To determine the impact of internationally recognised criteria for the diagnosis of heart failure with preserved ejection fraction (HF-PEF) on the identification of patients suitable for a clinical study of a novel therapeutic intervention. We reviewed the notes of 5883 patients admitted with heart failure across 8 hospitals in the ...
Yu Jin Xu X Oxford University - - 2014
A precise understanding and quantification of myocardial contraction is essential for optimising peri-operative care in high risk CABG surgery. Conventional approach has been focused on the magnitude of myocardial contraction, while its time course has received little clinical attention. This study was aimed to characterise the changes in both physiological ...
Fazlalizadeh Helen H Academic Cardiology/Castle Hill - - 2014
Type-2 diabetes mellitus (T2DM) is risk factor for developing cardiac dysfunction and heart failure. The plasma concentration of amino-terminal pro-brain natriuretic peptide (NT-proBNP) could be a simple tool for screening for cardiac dysfunction amongst older patients with T2DM. Patients receiving treatment for T2DM for at least 12 months, aged >40 ...
Zeb Mehmood M Southampton University - - 2014
Ambulatory cardiac monitoring devices and the novel subcutaneous ICD (SICD) sensing algorithms are based on the surface electrocardiograms (ECGs) parameters for detection and discrimination of arrhythmias. However the impact of posture, cardiac morphologies (normal and congenital heart diseases), and electrode placement on these parameters are not known. To determine the ...
Captur Gabriella G Institute of Cardiovascular Science, University College London, London, UKThe Inherited Cardiovascular Diseases Unit and Cardiac Imaging Department, The Heart Hospital, London, - - 2014
Left ventricular noncompaction (LVNC) is characterised by prominent ventricular myocardial trabeculations, composed of sheets of cardiomyocytes. They form early during cardiogenesis but their development is complex. Measuring trabecular complexity in animal models of cardiac disease is important as abnormal trabecular patterns are increasingly been recognised to coexist with several other ...
Emerson Barry B University of - - 2014
Increased H2S availability, through use of H2S donors, or in mice overexpressing the H2S synthetic enzyme cystathionine gamma-lyase (CSE), reduces injury associated with myocardial ischemia (MI) and ischemia-reperfusion. The mitochondrial enzyme thiosulfate sulfurtransferase (TST) has a putative role in removal of H2S and inhibition may provide an alternative means of ...
Zaman Junaid J Imperial College - - 2014
Hypertension and ageing are the commonest risk factors for atrial fibrillation (AF) and a significant cause of ventricular dysfunction, which may lead to arrhythmia. Putative factors in the remodelled substrate are connexin 43 (Cx43), the most abundant cardiac gap junction and fibrosis. The spontaneous hypertensive rat (SHR) has been demonstrated ...
Syeda Fahima F University of - - 2014
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death and right ventricular heart failure in young athletes. Loss-of-function mutations in desmosomal proteins including plakoglobin deficiency are linked with ARVC and ventricular arrhythmias in trained mice. Chronic intensive endurance training increases susceptibility to atrial arrhythmias in rats. ...
Williams Howell J HJ Department of Cardiology, Barts Health NHS - - 2014
Knowledge of cardiac arrest (CA) causes other than coronary artery disease is derived predominantly from post-mortem studies, identifying hypertrophic cardiomyopathy (HCM) as the commonest diagnosis. Management of CA survivors mandates definite attempts towards diagnosis, particularly as the cause may be inherited with implications for family screening. Our approach to non-ischaemic ...
Waltenberger Johannes J Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany. Electronic address: - - 2014
Intermittent dyssynchrony, induced by ventricular pacing, during early reperfusion reduces infarct size in pre-clinical studies. We evaluated cardioprotection by pacing post-conditioning (PPC) in ST-segment elevation myocardial infarction in a randomized, controlled, single-center, single-blinded, first-in-man study. Patients with first ST-segment elevation myocardial infarction received either PPC plus percutaneous coronary intervention (PCI) (n = ...
Hill Stanley E SE Critical Care Pharmacy Specialist, Long Beach Memorial Medical Center, Department of Inpatient Pharmacy, 2801 Atlantic Ave. Long Beach, CA, 90806. - - 2014
Migraine is a potentially debilitating neurologic disorder affecting approximately 12% of the United States population. Sumatriptan manufacturer-provided drug information states that life threatening arrhythmias, including ventricular tachycardia and ventricular fibrillation (VF), have been reported. A literature search revealed only seven reported cases of ventricular arrhythmias immediately after sumatriptan administration. Twenty ...
Sun Haihui H Department of Cardiology, The Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China ; Department of Cardiology, The Central Hospital of Tai'an, Tai'an, Shandong 271000, P.R. - - 2014
The aim of the present study was to investigate major cardiac events and the similarities and differences of medical costs among patients with multivessel complex coronary artery disease (MCCAD) during the three-year follow-up. The MCCAD patients had undergone single complete revascularization (CR), fractionated revascularization (FR) or partial revascularization (PR) and ...
Kydd Anna C AC Department of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United - - 2014
This study was conducted to assess the impact of left ventricular (LV) lead position on longer-term survival after cardiac resynchronization therapy (CRT). An optimal LV lead position in CRT is associated with improved clinical outcome. A strategy of speckle-tracking echocardiography can be used to guide the implanter to the site ...
Mosalpuria Kailash K Departments of Internal Medicine (Dr. Mosalpuria) and Cardiology (Dr. Pierre-Louis), Harlem Hospital Center affiliated with Columbia University, New York, New York 10037; Department of Medicine (Drs. Agarwal and Russell), Johns Hopkins University, Baltimore; Maryland 21205; Department of Epidemiology (Dr. Yaemsiri), University of North Carolina, Chapel Hill, North Carolina 27599; and Cardiovascular Institute (Drs. Agarwal, Alvarez, and Saba), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania - - 2014
Better outpatient management of heart failure might improve outcomes and reduce the number of rehospitalizations. This study describes recent outpatient heart-failure management in the United States. We analyzed data from the National Ambulatory Medical Care Survey of 2006-2008, a multistage random sampling of non-Federal physician offices and hospital outpatient departments. ...
Budoff Matthew J MJ Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California - - 2014
Atrial volumetric measurement has proven clinical implications. Advances in cardiac imaging, notably the precision enabled by multidetector computed tomography (MDCT), herald the need for new criteria of what constitutes normal volumetric measurements. With use of 64-slice MDCT, we compared the atrial volumes in healthy individuals with those in individuals with ...
Darda Saba S Department of Cardiology, Providence Hospital and Medical Center, South-field, Michigan - - 2014
In patients with cardiac sarcoidosis, the sarcoid granulomas usually involve the myocardium or endocardium. The disease typically presents as heart failure with ventricular arrhythmias, conduction disturbances, or both. Constrictive pericarditis has rarely been described in patients with sarcoidosis: we found only 2 reports of this association. We report the case ...
Martinez Sara C SC Department of Internal Medicine, Cardiovascular Division (Drs. Bradley, Cedars, Ewald, Joseph, Martinez, and Rasalingam; and Mr. Novak), and Department of Surgery, Division of Cardiothoracic Surgery (Dr. Silvestry), Washington University School of Medicine in St. Louis, St. Louis, Missouri - - 2014
Left ventricular assist device (LVAD)-supported patients are evaluated routinely with use of transthoracic echocardiography. Values of left ventricular unloading in this unique patient population are needed to evaluate LVAD function and assist in patient follow-up. We introduce a new M-mode measurement, the slope of the anterior mitral valve leaflet (SLAM), ...
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