Search Results
Results 301 - 350 of 7494
< 2 3 4 5 6 7 8 9 10 11 12 >
Michlik Katarzyna M - - 2014
Quadricuspid aortic valve (QAV) and ventricular septal defect (VSD) are congenital heart defects and have been described in both human and veterinary medical literature. A 5-year-old half-bred bay stallion was referred for surgical castration. Cardiac murmurs were heard on the presurgical clinical examination and the cardiac examination revealed subcutaneous oedema, ...
Pecha Simon S Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, - - 2014
Systemic inflammation may contribute to heart failure. PGE2 was recently suggested to mediate inflammation-induced impairment of cardiac function by desensitizing the murine heart to isoprenaline. Given the magnitude of the reported effect and the potential relevance, we sought to reproduce it in the human heart. Human trabeculae were prepared from ...
Shu-Ping Tian T Department of Radiology,General Hospital of PLA,Beijing 100853,China; Department of Radiology,3Department of Endocrinology,Navy General Hospital of PLA,Beijing - - 2014
Objective To assess the value of preoperative coronary computed tomographic angiography(CCTA)in the detection of coronary artery disease(CAD)in patients planned to undergo non-cardiac surgery at intermediate or high risk to avoid unnecessary invasive coronary angiography(ICA). Methods The study protocol was approved by our institutional review board and informed consent was given. ...
Leemasawat Krit K Cardiovascular Unit, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, - - 2014
Left ventricular-to-right atrial communication, known as Gerbode defect, is rare. However, right ventricular-to-left atrial communication is much rarer. We present a case of a middle-aged woman with a past history of primum atrial septal defect surgery who presented with dyspnea on exertion. Echocardiographic studies showed dehiscence of the pericardial atrial ...
Tölli Marja A MA Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, FI-90014 Oulu, - - 2014
Myocardial infarction (MI), commonly known as a heart attack, is the irreversible necrosis of heart muscle secondary to prolonged ischemia, which is an increasing problem in terms of morbidity, mortality and healthcare costs worldwide. Along with the idea to develop nanocarriers that efficiently deliver therapeutic agents to target the heart, ...
Mohite Prashant N PN Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK, - - 2014
Arthrogryposis multiplex congenita (AMC) is characterized by contractions of multiple joints present at birth. AMC is rarely associated with cardiomyopathy. We present a case of a young man with dilated cardiomyopathy associated with AMC admitted with rapidly deteriorating severe heart failure who was offered left ventricular assist device as a ...
Cavalli Giulio G aDepartment of Internal Medicine and Clinical Immunology bDepartment of Cardiology cDepartment of Radiology, IRCCS San Raffaele Scientific Institute, Milan, - - 2014
Almost invariably associated with chronic HCV infection, cryoglobulinemic vasculitis is a small-vessel vasculitis commonly affecting the skin, kidneys, and peripheral nervous system. Cardiac involvement, possibly due to cardiac microcirculation involvement, is an utterly rare and severe complication. We describe a case of hypertrophic cardiomyopathy secondary to cryoglobulinemic vasculitis. Evaluation with ...
Martins Telma T Mass Spectrometry Group, QOPNA, Department of Chemistry, University of Aveiro, - - 2014
Cardiac cachexia is a serious complication of chronic heart failure, characterized by significant weight loss and body wasting. Chronic heart failure-related muscle wasting results from a chronic imbalance in the activation of anabolic or catabolic pathways, caused by a series of immunological, metabolic, and neurohormonal processes. In spite of the ...
Singh Kuljit K Department of Cardiology, Queen Elizabeth Hospital, Adelaide, Australia. Electronic address: - - 2014
Takotsubo cardiomyopathy (TTC) is often associated with hypotension and shock. However, development of hypotension/shock in TTC is not closely related to extent of left ventricular (LV) hypokinesis. We sought to determine whether additional right ventricular (RV) involvement in TTC might contribute to hypotension and shock development and thus to prolonged ...
Cervellin Gianfranco G Emergency Department, Academic Hospital of Parma, Parma, - - 2014
The history of myocardial infarction (MI) diagnostics has gone through a continuous evolution over the past century, when several new discoveries have contributed to remarkably increase the number of patients appropriately diagnosed with this condition. The tale "of MIs and Men" displays rather a long history, since atherosclerosis was found ...
Lima-Leopoldo Ana Paula AP Federal University of Espirito Santo - - 2014
Few studies have evaluated the relationship between the duration of obesity, cardiac function and the proteins involved in myocardial calcium (Ca(2+)) handling. We hypothesized that long-term obesity promotes cardiac dysfunction due to a reduction of expression and/or phosphorylation of myocardial Ca(2+)-handling proteins. Thirty-day-old male Wistar rats were distributed into two ...
Lip Gregory Yh GY City Hospital, Birmingham, United Kingdom & Aalborg University, Aalborg, Denmark - - 2014
Advances in pharmacological and devices therapy have greatly improved prognosis in patients with systolic heart failure. Despite this congestive heart failure still bears a very grim prognosis, particularly in patients with more advances stages of the disease that are so frequently seen on hospital wards. Which pathogenic pathways may need ...
Ferrari Roberto R Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy - - 2014
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that ...
Peng Ying Y UW-Madison, United - - 2014
Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often precipitated by myocardial infarction (MI). However, the molecular changes driving cardiac dysfunction immediately after MI remain poorly understood. Myofilament proteins, responsible for cardiac contraction and relaxation, play critical roles in signal reception and transduction ...
Stallone Fabio F Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland Department of Cardiology, University Hospital Basel, Basel, - - 2014
Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. A total of 984 ...
Gorjup Vojka V Vojka Gorjup, Marko Noc, Peter Radsel, Department of Intensive Internal Medicine, University Medical Center Ljubljana, 1000 Ljubljana, - - 2014
Coronary artery disease is the most frequent cause of sudden cardiac death. There is general consensus that immediate coronary angiography with percutaneous coronary intervention (PCI) should be performed in all conscious and unconscious patients with ST-elevation myocardial infarction in post-resuscitation electrocardiogram. In these patients acute coronary thrombotic lesion ("ACS" lesion) ...
Malfitano Christiane C Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, - - 2014
While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease (IHD), animal data have so far pointed to a lower probability of IHD. Thus, the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned ...
Zhao Zhi-Gang ZG Intensive Care Unit, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, - - 2014
Embelin has been used to treat fever and inflammatory diseases for thousands of years. Although reports indicate that embelin has antiinflammatory effects, its effects on myocardial injury following cardiac arrest (CA) have not been previously explored. In this study, we aim to investigate the protective effects of embelin on myocardial ...
Karmali Kunal N KN Departments of Preventive Medicine and Medicine (Cardiology), Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, USA, - - 2014
Cardiac rehabilitation is an important component of recovery from coronary events but uptake and adherence to such programs are below recommended levels. In 2010, our Cochrane review identified some evidence that interventions to increase uptake of cardiac rehabilitation can be effective but there was insufficient evidence to provide recommendations on ...
Prunet Bertrand - - 2014
Although aneurysmal subarachnoid hemorrhage (SAH) is often complicated by myocardial injury, whether this neurogenic cardiomyopathy is associated with the modification of cardiac metabolism is unknown. This study sought to explore, by positron emission tomography/computed tomography, the presence of altered cardiac glucose metabolism after SAH. During a 16-month period, 30 SAH ...
Boopathy Archana V AV Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown promising outcomes. Notch1 signaling plays a critical role in cardiac development and in the survival, cardiogenic lineage commitment, and differentiation of cardiac stem/progenitor cells. In this study, we functionalized ...
de Waha Suzanne - - 2014
This study aimed to evaluate the incremental prognostic value of infarct size, microvascular obstruction (MO), myocardial salvage index (MSI), and left ventricular ejection fraction (LV-EFCMR) assessed by cardiac magnetic resonance imaging (CMR) in comparison to traditional outcome markers in patients with ST-elevation myocardial infarction (STEMI) reperfused by primary percutaneous intervention ...
Ganapathi Asvin M AM Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, - - 2014
Patients with thoracic aortic disease undergoing thoracic endovascular aortic repair (TEVAR) often have concomitant coronary artery disease and are at risk for perioperative adverse cardiac events. Despite this risk, the need for and extent of preoperative cardiac workup before TEVAR remain undefined. This study seeks to assess the adequacy of a ...
Borlaug Barry A BA The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, - - 2014
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials ...
Hatipoglu Suzan S Department of Cardiology, Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey, - - 2014
In the absence of mitral valve disease left atrial (LA) volume is a marker of diastolic dysfunction and its severity. This study investigated the relationship between left ventricular (LV) end diastolic pressure (LVEDP) and LA volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (RT3DE), in a ...
Myers J A JA Triangle Veterinary Referral Hospital, Raleigh, - - 2014
Information regarding cardiac changes in domestic cats with acromegaly is limited. The objective of this study was to describe the echocardiographic findings in cats with acromegaly. Eighteen cats diagnosed with acromegaly at Colorado State University between 2008 and 2012. Of these 18 cats, 11 had echocardiography performed. A retrospective review ...
Umoh Nsini A NA Department of Physiology & Biophysics, College of Medicine, Howard University, Washington, District of - - 2014
Clinical manifestations of alcohol abuse on the cardiac muscle include defective contractility with the development of heart failure. Interestingly, low alcohol consumption has been associated with reduced risk of cardiovascular disease. Although several hypotheses have been postulated for alcoholic cardiomyopathy and for the low-dose beneficial cardiovascular effects, the precise mechanisms ...
Zhang Yixuan Y UCLA, United - - 2014
Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked upregulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation (AF), which is accompanied by overproduction of reactive oxygen species (ROS). In the present study we investigated impact ...
Taggart Peter P The Heart Hospital, University College London, UK. Electronic address: - - 2014
Understanding the mechanisms of fatal ventricular arrhythmias is of great importance. In view of the many electrophysiological differences that exist between animal species and humans, the acquisition of basic electrophysiological data in the intact human heart is essential to drive and complement experimental work in animal and in-silico models. Over ...
Varvarousi Giolanda G University of Athens, Medical School, Greece, 75 Mikras Asias street, 11527, Athens, - - 2014
Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent benefits for long-term survival or favourable neurologic outcome. Levosimendan ...
Hatam Nima - - 2014
Disturbances of interatrial conduction have been proposed as one of the contributing mechanisms of postoperative atrial fibrillation (AF). P-wave dispersion has been recognized as a sensitive tool for detecting interatrial conduction disturbances. Doppler myocardial imaging (DMI) has been validated as a non-invasive tool to indirectly reflect electrical atrial activation and ...
Gournay Véronique V CHU de Nantes, Service de Cardiologie Pédiatrique, Nantes, France. Electronic address: - - 2014
The number of children in need of mechanical circulatory support has increased substantially over the last two decades, due to the technological progress made in surgery and intensive care, leading to improved survival of patients with congenital heart disease. In addition, primary myocardial dysfunction related to myocarditis or dilated cardiomyopathy ...
Vecchiati Alessandra A Alessandra Vecchiati, Sara Tellatin, Annalisa Angelini, Sabino Iliceto, Francesco Tona, Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, 35128 Padova, - - 2014
Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy (CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening ...
Zong Nobel N The NHLBI Proteomics Center at UCLA; Departments of Physiology and Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2014
Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets poly-ubiquitinated proteins for destruction, it itself is modifiable by ubiquitination. We aim to identify the exact ubiquitination sites on cardiac proteasomes and examine whether they are also subject to acetylations. Assembled cardiac 20S proteasome complexes were purified from ...
Gupta Saurabh Kumar SK Department of Cardiology, All India Institute of Medical Sciences, New Delhi, - - 2014
Atrial inversion (or mirror-imaged atrial arrangement) occurring in isolation, that is, without corresponding mirror imagery of the viscera, has been previously shown with discordant atrioventricular connections resulting in transposition physiology. We hereby report a case of "isolated atrial inversion" wherein atrioventricular connections were concordant owing to the presence of criss-crossing ...
Hidestrand Pip M PM Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI, USA - - 2014
We present a patient with complex single ventricle physiology who was subsequently diagnosed with atresia of the coronary sinus ostium in the setting of myocardial dysfunction following operative palliation. Although a rare cardiac defect, awareness is important as the coronary venous system will often drain to a left superior vena ...
Liu Xiaoyu X From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.); and Institute of Molecular Medicine, Peking University, Beijing, China - - 2014
Studies have reported that development of congestive heart failure is associated with increased endoplasmic reticulum stress. Double stranded RNA-activated protein kinase R-like endoplasmic reticulum kinase (PERK) is a major transducer of the endoplasmic reticulum stress response and directly phosphorylates eukaryotic initiation factor 2α, resulting in translational attenuation. However, the physiological ...
Shigeru Mayumi M aDepartment of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine bKobe University Graduate School of Health Sciences, Kobe cHyogo Brain and Heart Center, Himeji, - - 2014
A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between Tc-tetrofosmin (Tc-TF) myocardial scintigraphy and the response to CRT. Twenty-one patients ...
Arking Dan E DE 1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. - - 2014
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to ...
Waksmonski Carol A CA Columbia University Medical Center, 630 West 168th St, New York, NY 10032. Electronic address: - - 2014
There are multiple imaging modalities available for the assessment of pregnant women with known or suspected cardiac disease. Because of its safety and general availability, echocardiography is the preferred study of choice for the evaluation of ventricular function, valvular heart disease, congenital heart disease, evaluation of the aorta, and the ...
Chowdhury Arpita A Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, - - 2014
The cardiac extracellular matrix (ECM) undergoes a dynamic transition following myocardial infarction. Fibulin-6, an ECM protein is expressed in cell junctions particularly in tissues subjected to significant mechanical stress. Fibulin-6 deficiency results in defective cell migration in nematodes and early embryonic lethality in mice. The role of fibulin-6 in healthy ...
Cai Benzhi B Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, - - 2014
Our in vitro studies revealed that a transcription factor, Forkhead box protein O1 (FoxO1), negatively regulates the expression of NaV1.5, a main α subunit of the cardiac Na(+) channel, by altering the promoter activity of SCN5a in HL-1 cardiomyocytes. The in vivo role of FoxO1 in the regulation of cardiac ...
Rordorf Roberto R Department of Cardiology, IRCCS Fondazione Policlinico S. - - 2014
Background:Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated whether pro-inflammatory cytokines might predict the response to cardiac resynchronization therapy (CRT).Methods and Results:Plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 were assessed in 91 patients before CRT. Response to CRT was defined ...
Wang Lina L Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, - - 2014
Studies from our group and others have indicated that paracrine function is one of major mechanisms underlying stem cell-mediated cardioprotection. To improve therapeutic efficacy of cardiac stem cells (CSCs), modification of CSCs to enhance their paracrine actions is of great interest. We have shown previously that stem cells from female ...
Al Mohani Ghaliah G Arrhythmology and Electrophysiology, Centro Cardiologico Monzino, IRCCS, Via C Parea n. 4, 20138, Milan, Italy, - - 2014
Electrical storm (ES) is one of the most challenging clinical scenarios facing electrophysiologists, and in certain settings emergency ablation should be performed. The majority of ES occurs in patients with structural heart disease, predominantly coronary heart disease and nonischemic heart disease like right ventricular arrhythmogenic dysplasia and previous myocarditis as ...
Czompa Attila A Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, - - 2014
Cardiovascular diseases are primary cause of death worldwide, particularly among populations with sedentary lifestyles and diets rich in animal products and processed foods. Currently, public health countermeasures to these disorders focus on costly and often marginally effective interventions administered only after the development of disease. These countermeasures are mainly palliative ...
Drury Nigel E NE Department of Cardiothoracic Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, UK School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, - - 2014
Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome. In a prospective, randomized, ...
Ito Kohei K Department of Biological Information, Tokyo Institute of Technology, Yokohama, - - 2014
Background: Zebrafish have the ability for heart regeneration. However, another teleost animal model, the medaka, had not yet been investigated for this capacity. Results: Compared with zebrafish, the medaka heart responded differently to an injury: An excessive fibrotic response occurred in the medaka heart; and existing cardiomyocytes or cardiac progenitor ...
Armenian Saro H SH Population Sciences, City of Hope - - 2014
Purpose: To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. Experimental Design: Using a ...
Yasui Haruyo H Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, - - 2014
Engineering of three-dimensional (3D) cardiac tissues using decellularized extracellular matrix could be a new technique to create an "organ-like" structure of the heart. To engineer artificial hearts functionally comparable to native hearts, however, much remain to be solved including stable excitation-propagation. To elucidate the points, we examined conduction properties of ...
< 2 3 4 5 6 7 8 9 10 11 12 >