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Dai Dao-Fu DF Department of Pathology, University of Washington School of Medicine, Seattle, WA, - - 2014
Chronic right heart failure predisposes to hepatic passive congestion and centrizonal necrosis that may lead to hepatic fibrosis (cardiac sclerosis). Although there have been several studies on the histologic features of congestive hepatopathy, there is no available grading system. In this study we developed a novel grading system for congestive ...
Xing Daniel T DT The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, - - 2014
Heart failure (HF) is associated with a large increase in cardiac sympathetic nerve activity (CSNA), which has detrimental effects on the heart and promotes arrhythmias and sudden death. There is increasing evidence that arterial chemoreceptor activation plays an important role in stimulating renal SNA (RSNA) and muscle SNA in HF. ...
Streiff Cole C Pediatric Cardiology, Oregon Health & Science University, Portland, - - 2014
Quantitative left ventricular mass (LVM) as well as regional strain values may be obtained from full-volume real time 3D echocardiography data via semi-automated feature tracking and represent indices of heart function, both in health and disease. Fresh adult porcine and ovine hearts were passively pumped to simulate normal cardiac motion ...
Mewton Nathan N aHôpital Cardiovasculaire Louis Pradel, Department of Intensive and Coronary Care, Hospices Civils de Lyon, Bron bDepartment of Biostatistics, Hospices Civils de Lyon, Université Claude Bernard Lyon, Lyon cHôpital Cardiovasculaire Louis Pradel, Centre d'Investigation CliniqueUnité INSERM 1407 dHôpital Cardiovasculaire Louis Pradel, Department of Radiology, Hospices Civils de Lyon, Bron, - - 2014
The relationship of cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) with myocardial biomarkers and markers of inflammation in acute viral myocarditis is not clearly defined. We assessed the relationship of LGE with myocardial and inflammatory biomarkers measured during the acute phase of myocarditis and their predictive value on clinical ...
Smiley Dia D Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, College of Medicine, Cincinnati, - - 2014
The cardiac regenerative capacity of MRL/MpJ mouse remains a controversy. Although the MRL mouse has been reported to exhibit minimal scarring and subsequent cardiac regeneration after cryoinjury of the right ventricle, multiple studies have been unable to replicate this cardiac regenerative capacity after both cryogenic and coronary ligation cardiac injury. ...
Sohal Manav M Division of Imaging Sciences and Biomedical Engineering, King's College London, London, UK, - - 2014
Septal flash (SF) describes early inward motion of the ventricular septum in patients with left bundle branch block (LBBB), and correction corresponds to increased response to cardiac resynchronization therapy (CRT). SF has traditionally been assessed by echocardiography. We sought to determine if cardiac magnetic resonance (CMR) imaging could identify SF ...
Schidlow David N DN Department of Cardiology, Boston Children's Hospital, Boston, - - 2014
Introduction Prenatal diagnosis provides valuable information regarding a variety of congenital heart defects. Some defects occur early in gestation with little change throughout pregnancy, whereas others evolve during mid and late gestation. Fetal cardiac intervention (FCI) affords the opportunity to interrupt progression of disease in this latter category, resulting in improved ...
Krieger Eric V EV Division of Cardiology, Department of Medicine, Seattle Adult Congenital Heart Service, University of Washington Medical Center and Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, - - 2014
Heart failure (HF) is the leading cause of death in adults with repaired congenital heart disease (CHD). However there is currently little evidence to guide treatment strategies in this growing group of patients. Unlike the majority of HF, which is usually caused by LV systolic or diastolic dysfunction, CHD-HF is ...
Hee Leia L Cardiology Department, Liverpool Hospital, Sydney, New South Wales, Australia; South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, - - 2014
Patients with CKD have increased cardiovascular morbidity and mortality. This study investigated the prognostic value of common clinical echocardiographic parameters.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: There were 289 unselected consecutive patients who had a transthoracic echocardiogram between January and June 2003. Patients with stage 3 or 4 CKD (n=49) were compared ...
Olsen P P Department of Applied Sciences and Allied Health, Christchurch Polytechnic Institute of Technology, New Zealand - - 2014
The relationship between watching major sporting events and cardiac hospital admissions is contentious. This study is the first to investigate cardiovascular admissions during Rugby World Cup (RWC) tournaments. New Zealand (NZ) public hospital admissions data were analysed for cardiovascular events during the 1999, 2003, 2007 and 2011 RWC tournaments. The ...
Sousa Carla C Serviço de Cardiologia, Centro Hospitalar São João, E.P.E., Porto, Portugal. Electronic address: - - 2014
Post-cardiac injury syndrome (PCIS) is an inflammatory process involving the pericardium secondary to cardiac injury. It can develop after cardiac trauma, cardiac surgery, myocardial infarction, and, rarely, after certain intravascular procedures. We report a rare case of an iatrogenic cardiac rupture followed by PCIS with delayed inflammatory pericardial effusion after ...
Cabanelas Nuno N Serviço de Cardiologia, Hospital de Santarém, Santarém, Portugal. Electronic address: - - 2014
The demonstrated benefits of cardiac resynchronization therapy (CRT) in reducing mortality and hospitalizations for heart failure, improving NYHA functional class and inducing reverse remodeling have led to its increasing use in clinical practice. However, its potential contribution to complex ventricular arrhythmias is controversial.We present the case of a female patient ...
Aleong Ryan G RG University of Colorado, Division of Cardiology. Electronic address: - - 2014
Atrial Fibrillation and heart failure with reduced left ventricular ejection fraction have interrelated pathophysiologies. New onset atrial fibrillation in heart failure patients has been associated with increased mortality, but has not been definitively related to clinical heart failure progression. To test the hypothesis that new onset atrial fibrillation is related ...
Ling Liang-Han LH Department of Cardiovascular Medicine, Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; Cardiology Department, Royal Melbourne Hospital, Victoria, Australia; Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Victoria, - - 2014
The impact of diffuse atrial fibrosis detected by T1 mapping on atrial fibrillation(AF) ablation outcomes is unknown. To validate and assess the impact of post-contrast cardiac magnetic resonance imaging(CMR) atrial T1 mapping on the clinical outcome following catheter ablation for AF. CMR was performed in 3 groups using a clinical ...
Dusch Marie N MN Department of Radiology, University of California, San Francisco, - - 2014
Diastolic dysfunction contributes significantly to diastolic heart failure. We examined the use of cardiac magnetic resonance imaging (CMR) using midwall longitudinal fractional shortening (MLFS) in the evaluation of transthoracic echocardiogram (TTE)-evidenced diastolic dysfunction. A total of 80 patients with CMR within 6months of TTE and normal ejection fraction were identified. ...
Asimaki Angeliki A Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, - - 2014
Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To elucidate the underlying mechanisms and discover potential chemical modifiers, we created a zebrafish model of ACM with cardiac myocyte-specific expression of the human 2057del2 mutation in the gene encoding plakoglobin. A high-throughput screen identified SB216763 as a suppressor of the ...
Nguyen Tin T Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina Heart Institute, East Carolina University, Greenville, North - - 2014
Assessment of right ventricular (RV) function is important in the management of various forms of cardiovascular disease. Accurately assessing RV volume and systolic function is a challenge in day-to-day clinical practice due to its complex geometry. Tricuspid annular plane systolic excursion (TAPSE) and systolic excursion velocity (S') have been reviewed ...
Merz Waltraut M WM Department of Obstetrics and Prenatal Medicine, University Bonn Medical School, Bonn, - - 2014
During fetal life, cardiovascular dysfunction may arise in a variety of conditions; these include structural cardiac defects, primary myocardial diseases, cardiomyopathies, anemia and other diseases associated with volume load, twin-twin-transfusion syndrome in monochorionic pregnancies and fetal growth restriction. Intrauterine treatment, close surveillance and timely delivery have resulted in improved fetal-neonatal ...
Hu Jia J Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, - - 2014
Recent studies suggested association between impaired left ventricular long-axis function and arrhythmic events early after open heart surgery. This prospective study investigated the predictive value of a depressed intraoperative global longitudinal strain (GLS) for postoperative atrial fibrillation after isolated aortic valve replacement in patients with preserved ejection fraction. A total ...
Singh Vikas V Department of Cardiology, King George's Medical University, Lucknow, - - 2014
A case of circumferential moderate pericardial effusion causing isolated collapse of left ventricular cavity on two-dimensional echocardiography is reported. Pericardial effusion, mostly of infective etiology, is relatively common in this part of the world. When large enough to cause tamponade, collapse of right atrium, right ventricle, and uncommonly left atrium ...
Garcia-Tejada Julio J Department of Cardiology. Doce de Octubre University Hospital. Madrid. Spain. This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. Electronic address: - - 2014
Identification of acute coronary lesions amenable to urgent intervention in survivors of out-of-hospital cardiac arrest is crucial. We aimed to compare the clinical and electrocardiographic characteristics to urgent coronary findings, and to analyze in-hospital prognosis of these patients. From January-2005 to December-2012 we retrospectively identified consecutive patients resuscitated from out-of-hospital ...
Yamada Hirotsugu H Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan. Electronic address: - - 2014
This study sought to introduce and confirm the efficacy of pre-load stress echocardiography with leg-positive pressure (LPP) for improving risk stratification of patients with mild stable heart failure. Heart failure patients with mild symptoms and a poor prognosis should be identified and treated aggressively to improve clinical outcome. We performed ...
Wang Yabin Y Xijing Hospital, Cardiology, Xi`an, Shaanxi, China ; - - 2014
  Clinical application of cellular therapy for cardiac regeneration is significantly hampered by the low retention of engrafted cells, mainly attributable to the poor microenvironment dominated by inflammation and oxidative stress in the host's infarcted myocardium. This study aims to investigate whether Liver X receptor (LXR) agonist T0901317 will improve survival ...
Patra Soumya S 1Department of Cardiology,Sri Jayadeva Institute of Cardiovascular Sciences & - - 2014
Background: Cyanotic CHD comprises up to 25% of cases of all causes of CHD. Rationale: There is lack of data about the present spectrum of congenital cyanotic heart disease in the paediatric age group. Objective: The present study was undertaken to determine the spectrum of patients with congenital cyanotic heart ...
Diaz-Miron Jose L JL Department of Surgery, Division of Pediatric Surgery, Washington University School of Medicine, St Louis, - - 2014
Traumatic coronary artery dissection (CAD) after blunt chest trauma (BCT) is extremely rare, particularly in children. Among coronary dissections, left main coronary artery (LMCA) dissection is the least common, with only two pediatric cases reported previously. Manifestations of coronary dissections can range from ST segment changes to sudden death. However, ...
Bouhidel Jalaleddinne Omar JO Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095, - - 2014
Reperfusion injury of the heart is a severe complication of angioplasty treatment of acute myocardial ischemia, for which no therapeutics are currently available. The present study aimed to identify whether and how a novel protein netrin-1 induces cardioprotection in vivo during ischemia/reperfusion (I/R) injury. Wild type (WT) C57BL6/J mice were ...
Reynolds Joshua C JC Department of Emergency Medicine Michigan State University College of Human Medicine Grand Rapids, MI. Electronic address: - - 2014
Early CATH is recommended for cardiac arrest survivors with STEMI or suspicion for coronary ischemia. Comatose patients are at risk of death from neurologic injury irrespective of CATH, but post-procedural mortality data do not distinguish between causes of death. Pittsburgh Post Cardiac Arrest Category (PCAC) is a validated, early post-cardiac ...
Neunhäuserer Daniel D 1Sports Medicine Division, Department of Medicine - University of Padova, Padova, Italy; 2University Institute for Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Salzburg, Austria; 3Cardiac Magnetic Resonance Unit, Euganea Medica, Albignasego, Padova, - - 2014
Myocardial crypts are extensions of blood signal penetrating the compact myocardium and are considered in literature as either a distinctive cardiac magnetic resonance (CMR) imaging marker for hypertrophic cardiomyopathy or as benign congenital malformations. What if CMR reveals a myocardial crypt in the presence of an altered ECG in an ...
Lu Tse-Min - - 2014
In congestive heart failure the balance between cell death and cell survival in cardiomyocytes is compromised. Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against ischemia/reperfusion injury in murine heart. The role of Sirt1 in heart failure, especially in human hearts is not clear. ...
Jin Chunhua C Department of Surgery, University of Colorado Denver, Aurora, Colorado Center for Experimental Medicine, Southern Medical University, Guangzhou, - - 2014
The myocardial inflammatory response contributes to cardiac functional injury associated with heart surgery obligating global ischemia and reperfusion (I/R). Toll-like receptors (TLRs) play important roles in the mechanism underlying myocardial I/R injury. The aim of this study was to examine the release of small constitutive heat shock proteins (HSPs) from ...
Lowalekar Samar K SK Division Cardiothoracic Surgery, Department of Surgery, Harvard Medical School, Boston, Massachusetts; Department of Surgery, Brigham and Women׳s Hospital, Boston, Massachusetts; VA Boston Healthcare System, Boston, - - 2014
Hearts preserved ex vivo at extreme hypothermia (4°C) undergo time-dependent irreversible injury. Our studies using a novel solution, Somah, suggest that hearts are viably preserved at 21°C. In this study we evaluate the relative efficacy of Somah for preservation of hearts at 21°C when compared with the clinically used Celsior ...
Fraccarollo Daniela D Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30175, Hannover, - - 2014
Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether stimulating the NO/heme-independent sGC provides additional ...
van Rijsingen Ingrid A W IA Department of Cardiology, Academic Medical Center, Amsterdam, the - - 2014
-The pathogenic phospholamban (PLN) R14del mutation causes dilated and/or arrhythmogenic right ventricular cardiomyopathies and is associated with an increased risk of malignant ventricular arrhythmias and end-stage heart failure. We performed a multicentre study to evaluate mortality, cardiac disease outcome, and risk factors for malignant ventricular arrhythmias in a cohort of ...
Hong Jueun J Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul 120-752, Republic of Korea; Korea Testing & Research Institue (KTR), 155 Beodeunaru-ro, Yeongdeungpo-gu, Seoul 150-038, Republic of - - 2014
Inflammatory response in myocardial ischemia-reperfusion injury plays a critical role in ventricular remodeling. To avoid deleterious effects of overwhelming inflammation, we blocked the expression of receptor for advanced glycation end-products (RAGE), a key mediator of the local and systemic inflammatory responses, via RNAi mechanism. Herein, a facial amphipathic deoxycholic acid-modified ...
Braggion-Santos Maria Fernanda MF Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg 69120, Germany School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, - - 2014
Cardiac allograft vasculopathy (CAV), which limits long-term survival after heart transplantation (HTX), is usually evaluated by coronary angiography (CA). Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) is a non-invasive technique that can detect CAV-related myocardial infarctions. We aimed to investigate the presence of LGE infarct-typical patterns in a large sample ...
Wilson W M WM Edinburgh Heart Centre, Edinburgh, Scotland, United - - 2014
This case illustrates a potential complication of the retrograde approach using epicardial collaterals for chronic total occlusion PCI. Hypotension post chronic total occlusion percutaneous coronary intervention in a patient who has undergone previous cardiac surgery can have multiple causes, one of which is chamber compression from a localized haematoma due ...
Sun Lijun L Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, - - 2014
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein-10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. ...
Yi Colin J CJ Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Rm 10/1C355, Bethesda, MD, 20892, - - 2014
To evaluate long-term changes in diffuse myocardial fibrosis using cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) and T1 mapping. Patients with chronic stable cardiomyopathy and stable clinical status (n = 52) underwent repeat CMR at a 6 month or greater follow up interval and had LGE and left ventricular (LV) T1 ...
Meyer Christian G CG Medical Clinic I, University RWTH Aachen, Pauwelsstraße 30, Aachen 52074, - - 2014
This study analysed the impact of transapical (TA) vs. transfemoral (TF) access site transcatheter aortic valve implantation (TAVI) on post-procedural regional left ventricular (LV) function using cardiac magnetic resonance (CMR) feature tracking (FT). CMR was performed 3 months after TAVI on 44 consecutive patients with normal LV ejection fraction prior ...
Adhyapak Srilakshmi M SM Department of Cardiology, St John's Medical College Hospital, Bangalore, India - - 2014
In patients with previous myocardial infarction, the remote uninfarcted regions, although contractile, demonstrate dysfunctional wall kinetics because of increased afterload, which improves after surgical ventricular restoration (SVR). We characterized left ventricular (LV) mean myocardial velocity (MMV) through an analysis of endocardial motion and wall thickening (WT) over the cardiac cycle ...
Hasumi Yukiko Y Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, - - 2014
Cardiac hypertrophy, an adaptive process that responds to increased wall stress, is characterized by the enlargement of cardiomyocytes and structural remodeling. It is stimulated by various growth signals, of which the mTORC1 pathway is a well-recognized source. Here, we show that loss of Flcn, a novel AMPK-mTOR interacting molecule, causes ...
Lossie Janine J University Medicine Berlin Charité, Experimental and Clinical Research Center (ECRC), - - 2014
The essential myosin light chain (ELC) is involved in modulation of force generation of myosin motors and cardiac contraction, while its mechanism of action remains elusive. We hypothesized that ELC could modulate myosin stiffness which subsequently determines its force production and cardiac contraction. We therefore generated heterologous transgenic mouse (TgM) ...
Almehmadi Fahad F Department of Internal Medicine, Department of Medicine, London Health Sciences Centre, London, - - 2014
-Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) is increasingly performed in patients with systolic dysfunction. Numerous patterns of fibrosis are commonly reported among this population. However, the relative prevalence and prognostic significance of these findings remains uncertain. -Three hundred and eighteen consecutive patients referred for LGE-CMR and a left ...
Caetano Francisca F Serviço de Cardiologia, Hospital Geral, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address: - - 2014
The prognostic value of late gadolinium enhancement (LGE) for risk stratification of hypertrophic cardiomyopathy (HCM) patients is the subject of disagreement. We set out to examine the association between clinical and morphological variables, risk factors for sudden cardiac death and LGE in HCM patients. From a population of 78 patients ...
Muehling Olaf M - - 2014
Conventional cardiac pacemakers are still often regarded as a contraindication to magnetic resonance imaging (MRI). We conducted this study to support the hypothesis that it is safe to scan patients with cardiac pacemakers in a 1.5 Tesla MRI, if close supervision and monitoring as well as adequate pre- and postscan ...
Wu Cho-Kai CK Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, - - 2014
Anti-anxiety medication in patients with anxiety may lessen the stress and thereby lower their risk for myocardial infarction (MI). The aim of current study is to examine an association between the use of anti-anxiety medication and long-term mortality risk in patients following MI. A universal national health insurance (NHI) program ...
Mortensen Eric M EM VA North Texas Health Care System, Dallas2University of Texas Southwestern Medical Center, - - 2014
Although clinical practice guidelines recommend combination therapy with macrolides, including azithromycin, as first-line therapy for patients hospitalized with pneumonia, recent research suggests that azithromycin may be associated with increased cardiovascular events. To examine the association of azithromycin use with all-cause mortality and cardiovascular events for patients hospitalized with pneumonia. Retrospective ...
Lal Hind H Temple University School of Medicine, Philadelphia, - - 2014
-Myocardial infarction-induced remodeling includes chamber dilatation, contractile dysfunction, and fibrosis. Of these, fibrosis is the least understood. Following MI, activated cardiac fibroblasts (CFs) deposit extracellular matrix. Current therapies to prevent fibrosis are inadequate and new molecular targets are needed. -Herein we report that GSK-3β is phosphorylated (inhibited) in fibrotic tissues ...
Adhyapak Srilakshmi M SM Department of Cardiology, St John's Medical College Hospital, Bangalore, India - - 2014
Clinical outcomes of surgical ventricular restoration (SVR) have been confirmed by Registry data. Accurate assessment of left ventricular (LV) morphology and function can help optimize these outcomes. LV remodelling in 7 patients (NYHA class 3 ± 1.2) with post-myocardial infarction LV aneurysms was characterized by the regional LV volume (RLVV) ...
Lin Zhiqiang Z Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, - - 2014
Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable to overcome the fundamental problem of regenerating lost cardiomyocytes. Several strategies for promoting heart regeneration have emerged from decades of intensive study. Although some of these strategies remain confined ...
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