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Bennett Noel M NM From the *Keck School of Medicine of the University of Southern California; and †Department of Radiology, LAC+USC Medical Center, Los Angeles, - - 2014
Diastolic dysfunction is commonly associated with heart failure with preserved systolic function. Diastolic abnormality includes progressively impaired left ventricle (LV) relaxation, followed by pseudonormal mitral inflow pattern with Valsalva enhancement, and finally restrictive LV filling. Diastolic dysfunction may lead to left atrial dilatation with consequent atrial fibrillation. Gated myocardial perfusion ...
Andersen Mads J MJ The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, - - 2014
Heart failure (HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in western countries. Approximately one-half of patients with HF have preserved ejection fraction (HFpEF). In contrast to HF with reduced EF (HFrEF), there is no proven effective treatment for ...
Kolte Dhaval D From the *Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY; †Scottsdale Healthcare, Scottsdale Cardiovascular Center, Scottsdale, AZ; and ‡Department of Medicine & Pharmacology, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, - - 2014
Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular ...
Díaz Olga M Seco OM Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA - - 2014
Objective-To determine prevalence of myocardial injury in horses with colic on the basis of high concentrations of cardiac troponin I (cTnI), frequency of cardiac arrhythmias within the first 24 to 48 hours after hospital admission or surgery because of colic, and associations between high cTnI concentrations and cardiac arrhythmias, clinical ...
García-Prieto Jaime J Imaging, Epidemiology and Atherothrombosis Department, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, - - 2014
Selective stimulation of β3 adrenergic-receptor (β3AR) has been shown to reduce infarct size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term effect and the cardioprotective mechanisms at the level of cardiomyocytes have not been elucidated, and the impact of β3AR stimulation has not been evaluated in a ...
Hong Kyung U KU Institute of Molecular Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY, 40202, USA, - - 2014
The discovery of adult cardiac stem cells (CSCs) and their potential to restore functional cardiac tissue has fueled unprecedented interest in recent years. Indeed, stem-cell-based therapies have the potential to transform the treatment and prognosis of heart failure, for they have the potential to eliminate the underlying cause of the ...
Tadros Rafik R Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Québec, Canada; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Québec, - - 2014
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in epidemiologic and investigative studies as well as in daily patient care. At the supraventricular level, women are at increased risk of sick sinus syndrome and atrioventricular (AV) node re-entrant tachycardia, whereas men manifest more AV block and accessory pathway-mediated ...
Lee Hye Young HY Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ; Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, - - 2014
Recent studies show positive association of early repolarization (ER) with the risk of life-threatening arrhythmias in patients with coronary artery disease (CAD). This study was to investigate the relationships of ER with myocardial scarring and prognosis in patients with CAD. Of 570 consecutive CAD patients, patients with and without ER ...
Duerr Georg D GD Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, - - 2014
Ischemic heart disease is associated with inflammation, interstitial fibrosis and ventricular dysfunction prior to the development of heart failure. Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be involved, but their potential role in cardioprotection is not well understood. We therefore explored the role of the cannabinoid receptor ...
Beake Matthew Jonathan MJ 1Neonatal Unit,Birmingham Women's Hospital NHS Trust,Birmingham,United - - 2014
A preterm 29-week gestation baby was delivered because of gross foetal hydrops secondary to congenital complete heart block. Despite a poor prognosis, she survived stabilisation and received emergency epicardial pacing followed by permanent pacemaker insertion on day 13, weighing 1.2 kg.
Qi Dake - - 2014
The cellular response to stress involves the recruitment and coordination of molecular signaling pathways that prevent cell death. D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic substrates in mammalian cells, but shares partial sequence and structural homology with macrophage migration inhibitory factor (MIF). Here, we observed that DDT is ...
Güder Gülmisal G Comprehensive Heart Failure Center, University of Würzburg, Würzburg, - - 2014
Heart failure and COPD are very common in the elderly. As both syndromes share common risk factors, such as tobacco smoking, and pathophysiological pathways, including systemic inflammation and activation of the neurohumoral system, they frequently coincide. Because of the similar clinical presentation, diagnoses of COPD in the presence of heart ...
Arcaro Alessia A IRCCS Neuromed, Pozzilli, IS, - - 2014
The loss of contractile function is a hallmark of heart failure. Although increasing intracellular Ca(2+) is a possible strategy for improving contraction, current inotropic agents that achieve this by raising intracellular cAMP levels, such as β-agonists and phosphodiesterase inhibitors, are generally deleterious when administered as long-term therapy due to arrhythmia ...
Donaldson Erin E EE Baylor Heart and Vascular Institute (Donaldson, Ko, Roberts) and the Departments of Internal Medicine, Division of Cardiology (Kuiper, Roberts), Pathology (Roberts), and Cardiothoracic Surgery (Chamogeorgakis), Baylor University Medical Center at Dallas. Dr. Donaldson is now with the Department of Family Medicine, Methodist Charlton Medical Center, Dallas, - - 2014
Described herein is a 68-year-old man who underwent cardiac transplantation for severe chronic heart failure resulting from ischemic cardiomyopathy. Examination of the excised heart showed not only extensive left ventricular scarring but also a huge collection of adipose tissue in the subepicardial region and surprisingly also in the ventricular septum. ...
De Viti D D Cardiology Unit, Casa di Cura Santa Maria, Bari, - - 2014
We present a case of large pedunculated myxoma (61×39 mm) in the left ventricular cavity with anterior-septal and anterior free wall akinesia. Angiographic study showed normal coronary arteries, but the clinical signs strongly suggested a previous myocardial infarction. We cannot exclude the possibility that the ventricular akinesia results from embolization ...
Papadaniil Chrysa D - - 2014
An efficient heart sound segmentation (HSS) method that automatically detects the location of first ( S1) and second ( S2) heart sound and extracts them from heart auscultatory raw data is presented here. The heart phonocardiogram is analyzed by employing ensemble empirical mode decomposition (EEMD) combined with kurtosis features to ...
Richards A Mark AM Cardiac Department, Cardiovascular Research Institute, National University Heart Centre, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228, Singapore; Department of Medicine, Christchurch Heart Institute, University of Otago, Christchurch, 2 Riccarton Avenue, Christchurch 8140, New Zealand. Electronic address: - - 2014
Timely diagnosis, early introduction of appropriate treatment, accurate risk stratification, and optimal titration of therapy are all key to the management of acute and chronic heart failure (HF). Plasma concentrations of the cardiac natriuretic peptides (NPs) are valuable aids in each of these elements of care. However, most data are ...
Kovács Arpád A Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, - - 2014
Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent ...
Ki Young-Jae YJ Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of - - 2014
The aim of this study was to determine the associations of brachial-ankle pulse wave velocity (baPWV), high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the development of adverse outcomes after percutaneous coronary intervention (PCI). The baPWV, hs-cTnT and NT-proBNP were analyzed in 372 patients who ...
Bottio Tomaso T Department of Cardiology and Cardiovascular Surgery, University of Padova Medical School, Padova, Italy - - 2014
Mechanical support by means of ventricular assist devices is at present the most promising alternative of efforts aimed at increasing the supply of donor organs. The support of the left dysfunctional ventricle enables appropriate haemodynamic stabilization and recovery of secondary organ failure, often present in these severely ill patients. The ...
Ng Lauren L Division of Critical Care and Neurotrauma and Cerebrovascular Diseases, Department of Neurology, Thomas Jefferson University, 901 Walnut Street, 4th Floor, Philadelphia, PA 19107, USA; Division of Critical Care and Neurotrauma, Department of Neurological Surgery, Thomas Jefferson University, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, - - 2014
In this review, cardiac arrest is discussed, with a focus on neuroprognostication and the emerging data, with regard to identifying more accurate predictors of neurologic outcomes in the era of therapeutic hypothermia. Topics discussed include recent controversies with regard to targeted temperature management in comatose survivors of cardiac arrest; neurologic ...
Peterss Sven S Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany Department of Cardiac Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, - - 2014
Different revascularization strategies for patients with acute myocardial infarction (AMI) exist. It remains unclear whether ventricular unloading using cardiopulmonary bypass (CPB) or extracorporeal life support (ECLS) has an impact on early postischaemic ventricular function. Here, we report on the results of an approach using a miniaturized CPB in a well-established ...
Hunter Christopher L CL Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, - - 2014
Differentiating between cardiac and obstructive causes for dyspnoea is essential for proper management, but is difficult in the prehospital setting. To assess if prehospital levels of end-tidal carbon dioxide (ETCO2) differed in obstructive compared to cardiac causes of dyspnoea, and could suggest one diagnosis over the other. We conducted a ...
Shah Kevin S KS Department of Internal Medicine, University of California, San Diego, 402 Dickinson Street, Suite 380, San Diego, CA 92103-8425, - - 2014
Heart failure with preserved ejection fraction (HFPEF) is a common subtype of heart failure with morbidity and mortality similar to that of heart failure with systolic dysfunction. This article discusses the numerous biomarkers that promise to play a substantial role in terms of our ability to understand the mechanisms of ...
Gupta Deepak K DK Vanderbilt Heart and Vascular Institute, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Ave, Suite 300, Nashville, TN 37203, - - 2014
Heart failure (HF) with preserved ejection fraction (HFpEF) is becoming the predominant form of HF. Understanding cardiac structure and function in this syndrome is highly relevant for diagnosis, prognosis, pathophysiology, and management. However, identifying cardiac dysfunction in HFpEF can be challenging and requires an integrated assessment of cardiac structure, systolic ...
Denfeld Quin E QE Quin E. Denfeld, BSN, RN PhD Student, School of Nursing, Oregon Health & Science University, Portland. James O. Mudd, MD Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Jill M. Gelow, MD, MPH Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Christopher Chien, MD Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Shirin O. Hiatt, MPH, MS, RN Research Associate, School of Nursing, Oregon Health & Science University, Portland. Christopher S. Lee, PhD, RN, FAHA Assistant Professor, School of Nursing and Knight Cardiovascular Institute, Oregon Health & Science University, - - 2014
There is a common dissociation between objective measures and patient symptomatology in heart failure (HF). The aim of this study was to explore the relationship between cardiac biomechanics and physical and psychological symptoms in adults with moderate to advanced HF. We performed a secondary analysis of data from 2 studies ...
King Christopher C Medical Critical Care Service, Inova Fairfax Hospital, 618 South Royal Street, Alexandria, VA 22314, USA. Electronic address: - - 2014
Right ventricular failure complicates several commonly encountered conditions in the intensive care unit. Right ventricular dilation and paradoxic movement of the interventricular septum on echocardiography establishes the diagnosis. Right heart catheterization is useful in establishing the specific cause and aids clinicians in management. Principles of treatment focus on reversal of ...
McKie Paul M PM Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, - - 2014
High-sensitivity cardiac troponin assays have potent prognostic value in stable cardiovascular disease cohorts. Our objective was to assess the prognostic utility of a novel cardiac troponin I (cTnI) high-sensitivity assay, independently and in combination with amino-terminal pro-B-type natriuretic peptide (NT-proBNP), for the future development of heart failure and mortality in ...
Al-Zaiti Salah S SS Department of Acute and Tertiary Care, School of Nursing, University of Pittsburgh, PA, USA. Electronic address: - - 2014
This study evaluated the prognostic value of electrocardiogram (ECG)-based predictors in the primary prevention of sudden cardiac arrest (SCA) among ischemic cardiomyopathy patients with depressed left ventricular ejection fraction (LVEF ≤35%). The prediction of cause-specific mortality in high-risk patients offers the potential for targeting specific therapies (i.e., implantable cardioverter-defibrillator [ICD]). ...
Peng Hui H Section of Electrophysiology, Division of Cardiology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, - - 2014
Left atrial flutter (left AFL) is common in patients who undergo atrial fibrillation ablation and cardiac surgery; however, few reports describe left AFL in detail in a seemingly normally structured heart, and the mechanisms of the occurrence of such arrhythmia are still not clear. We describe left AFL in patients ...
Braunwald Eugene E TIMI Study Group, Cardiovascular Division, Brigham and Women׳s Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Modern cardiology was born early in the twentieth century. Here I list and review what I believe to be the ten most important advances in the twentieth century in this field. They are as follows: electrocardiography, cholesterol-induced atherosclerosis, cardiac catheterization, cardiovascular surgery, coronary angiography and percutaneous coronary angioplasty, the coronary ...
Edwards Nicola C NC Birmingham Cardio-Renal Group, University of Birmingham and Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. Electronic address: - - 2014
Chronic kidney disease (CKD) is an under-recognized, highly prevalent cardiovascular (CV) risk factor affecting 1 in 7 adults. Large epidemiological studies have clearly established a graded association between the severity of CKD and CV event rates. Although patients with end-stage renal disease who are undergoing dialysis are at greatest CV risk, ...
Asnani Aarti A Massachusetts General Hospital Cardiovascular Research Center, Harvard Medical School, Charlestown, MA 02129, - - 2014
Over the past decade, the zebrafish has become an increasingly popular animal model for the study of human cardiovascular disease. Because zebrafish embryos are transparent and their genetic manipulation is straightforward, the zebrafish has been used to recapitulate a number of cardiovascular disease processes ranging from congenital heart defects to ...
Rana Bushra S BS Consultant Cardiologist at Papworth Hospital, Papworth Everard, Cambridgeshire CB23 - - 2014
This article looks at the role of three-dimensional echocardiography in the anatomical assessment of cardiac structures, how this complements standard methods of assessing structural cardiac lesions and the advantages of three-dimensional echocardiography in peri-procedural guidance in the cardiac catheterization laboratory.
Wu Caijun C Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, - - 2014
The two most prevalent causes of sudden cardiac death are ventricular fibrillation cardiac arrest (VFCA) and asphyxiation cardiac arrest (ACA). Profound postresuscitation myocardial dysfunction has been demonstrated in both VFCA and ACA animal models. Our study aimed to characterize the two porcine models of cardiac arrest and postresuscitation myocardial metabolism ...
Allan Robert - - 2014
Free-floating (easily aroused) hostility is a cardinal symptom of the type A behavior pattern, the first psychosocial factor scientifically linked to coronary artery disease (CAD). Anger and hostility are associated with the onset and outcome of CAD, triggering of myocardial infarction, and lowering the threshold to ventricular arrhythmia, all increasing ...
Choudhury Partha Prateem PP Department of Cardiology, GB Pant Hospital, New Delhi, - - 2014
A 58 year old male, known case of type 2 diabetes and hypertension, had undergone implantation of a dual chamber pacemaker(DDDR) in 2007 for complaints of recurrent syncope and trifascicular block with a normal ejection fraction andnormal coronaries. His post implantation parameters were normal at that time.He now presented to ...
- - 2014
[This corrects the article on p. 217 in vol. 14, PMID: 25057224.].
Wu Cai Jun CJ Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, - - 2014
To study the application of positron emission tomography (PET) in detection of myocardial metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Thirty-two healthy miniature pigs were randomized into a ventricular fibrillation cardiac arrest (VFCA) group (n=16) and an asphyxiation cardiac arrest (ACA) group (n=16). Cardiac arrest ...
Nguyen Vivian B VB Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, - - 2014
High alcohol consumption during pregnancy leads to deleterious effects on fetal cardiac structure and it also affects cardiomyocyte growth and maturation. This study aimed to determine whether low levels of maternal alcohol consumption are also detrimental to cardiomyocyte and cardiac growth in the early life of offspring and whether cardiac ...
Yıldız Mustafa M Department of Cardiology, Kartal Koşuyolu Heart Training and Research Hospital, İstanbul, - - 2014
Objectives: Typical atrioventricular nodal reentrant tachycardia (AVNRT) can be cured with slow pathway ablation. This study was designed to assess the alterations in atrial and ventricular functioning using speckle tracking echocardiography in consecutive patients with typical AVNRT who underwent slow pathway radiofrequency (RF) ablation. Study design: Included in this study ...
Göksülük Hüseyin H Department of Cardiology, Ankara University Faculty of Medicine, Ankara, Turkey. - - 2014
Isolated congenital left ventricular (LV) diverticulum, which is characterized by the local failure of the ventricular muscle, is a rare cardiac abnormality with a reported prevalence of 0.4%. Clinically, it has been reported to follow an asymptomatic course in the majority of cases; however, it may cause heart failure, thrombus ...
Lu Xi X Xi Lu, Molecular Imaging Laboratory, Department of Radiology, West China Hospital, Sichuan University, No.1, Ke Yuan Road 4, Gao Xin District, Chengdu, 610041, Sichuan, - - 2014
Cardiovascular disease is the leading cause of mortality worldwide. Stem cell transplantation has become a new treatment option for cardiovascular disease because the stem cells are able to migrate to damaged cardiac tissue, repair the myocardial infarction area and ultimately reduce the role of the infarct-related mortality. Cardiac magnetic resonance ...
Yang Xuejun X Institute of Kidney Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, - - 2014
To observe the efficacy of Shenxinning Decoction (SXND) in ventricular remodeling in AT1 receptor-knockout (AT1-KO) mice with chronic renal insufficiency (CRI). AT1-KO mice modeled with subtotal (5/6) nephrectomy were intervened with SXND for 12 weeks. Subsequently, blood urea nitrogen (BUN), serum creatinine (SCr), brain natriuretic peptide (BNP), echocardiography (left ventricular ...
Sabzi Feridoun F Department of Cardiovascular Surgery, Imam Ali Heart Center, Kermanshah University of Medical Sciences, Kermanshah, - - 2014
Refractory cardiogenic shock meant that traditional patch repairs requiring cardiopulmonary bypass would be poorly tolerated and external sandwich closure of post myocardial ventricular septal defect (VSD) appears to be simple and effective after initial myocardial infarction (MI). The three cases presented with a VSD after of acute MI with or ...
Unlüer Erden Erol EE Department of Emergency Medicine, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, - - 2014
Penetrating cardiac injuries are rarely reported in the literature. Foreign bodies are rarely seen in the heart and most patients with penetrating cardiac injuries die from hemorragic or pericardial tamponade before arriving at the hospital. Bedside ultrasonography is a highly valuable and readily learned tool that has expanded rapidly since ...
Yolcu Mustafa M Department of Cardiology, Erzurum Region Training and Research Hospital, Erzurum, Turkey. - - 2014
Cardiac tamponade (CT) is a clinical entity characterized by hemodynamic insufficiency resulting from increased intrapericardial pressure due to accumulation of contents such as serous fluid, blood, and pus. CT is a treatable cause of cardiogenic shock, which can be fatal unless diagnosed promptly. Dyspnea, chest pain, hypotension, tachycardia, pulsus paradoxus, ...
Chen Wei-Kung WK Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40440, Taiwan, Republic of - - 2014
Obesity is often associated with the development of cardiac hypertrophy but the hypertrophyrelated pathways in obesity remain unknown. The purpose of this study was to evaluate cardiac hypertrophy-related markers, atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), tumor necrosis factor-alpha (TNFα) and hypertrophy-related pathways, interleukin (IL)-6-STAT3, IL-6-MEK5-ERK5 and calcineurin-nuclear factor ...
Wang Han-Jun HJ From the Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, - - 2014
The enhanced cardiac sympathetic afferent reflex (CSAR) contributes to the exaggerated sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively related to mortality in patients with CHF. However, the potential beneficial effects of chronic CSAR deletion on cardiac and autonomic function in CHF have not been previously explored. Here, ...
Löfsjögård Johan - - 2014
Abstract Objectives: Alterations of collagen metabolism present in heart failure promote the fibrotic substrate for the development of atrial fibrillation. Myocardial collagen I synthesis and degradation can be assessed indirectly by the circulating biomarkers carboxy-terminal propeptide (PICP) and carboxy-terminal telopeptide (CITP), respectively. Design: We examined myocardial collagen type I metabolism ...
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