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Ozgür Senem S Department of Cardiology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, - - 2014
Double outlet right ventricle is a cardiac malformation in which both the aorta and pulmonary artery arise from the right ventricle. A double outlet right ventricle with intact ventricular septum is extremely rare. A nine-day-old boy born at 38 weeks with a birth weight of 3200 g was referred due ...
Gamba Laurent L Saban Research Institute and Heart Institute,Children's Hospital Los Angeles, 4650 Sunset Blvd. MS#137, Los Angeles, CA, 90027, - - 2014
Myocardial infarction is the most common cause of cardiac injury in humans and results in acute loss of large numbers of myocardial cells. Unfortunately, the mammalian heart is unable to replenish the cells that are lost following a myocardial infarction and an eventual progression to heart failure can often occur ...
Cheung Yiu-Fai YF Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, - - 2014
Significant improvement in survival of children with congenital cardiac malformations has resulted in an increasing population of adolescent and adult patients with congenital heart disease. Of the long-term cardiac problems, ventricular dysfunction remains an important issue of concern. Despite corrective or palliative repair of congenital heart lesions, the right ventricle, ...
Hu Wei - - 2014
Abstract C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. After 8 weeks treatment, mice with dilated cardiomyopathy developed serious cardiac dysfunction characterized by significantly enhanced left ventricular end-diastolic diameter (LVIDd), decreased left ventricular ejection fraction ...
Vizzardi Enrico E Department of Applied and Experimental Medicine, Chair of Cardiology, University of Brescia, - - 2014
Right ventricular (RV) systolic dysfunction is a strong prognostic predictor in chronic heart failure (HF). However, assessment of RV function remains difficult. We investigated the prognostic value of different echocardiographic parameters for evaluating RV function in 60 patients with chronic HF and a low left ventricular ejection fraction (<40%) who ...
Putniković Biljana - - 2014
Spontaneous coronary artery dissection (SCAD) is a rare cause of the acute coronary syndrome. It occurs mostly in patients without atherosclerotic coronary artery disease, carrying fairly high early mortality rate. The treatment of choice (interventional, surgical, or medical) for this serious condition is not well-defined. A 41-year old woman was ...
Patel Nikhil N Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North - - 2014
The goal of treatment for atrial fibrillation (AF) is often to control symptoms. It remains unclear whether targets for treatment such as AF rate or AF burden are correlated with AF symptom severity. Two hundred eighty-six patients completed a questionnaire of their general health and well-being, including a detailed AF ...
Kim Yeo Koon YK Department of Radiology, Seoul National University Hospital, Seoul 110-744, - - 2014
Herein we report about the adenosine stress perfusion MR imaging findings of a 50-year-old man who exhibited two different perfusion defects resulting from two different mechanisms after a coronary artery bypass surgery. An invasive coronary angiography confirmed that one perfusion defect at the mid-anterior wall resulted from an ischemia due ...
Desimone Christopher V CV Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, - - 2014
Right ventricular apical pacing may cause or worsen mitral regurgitation (MR). Potential mechanisms for this adverse sequelae include intraventricular dyssynchrony, altered papillary muscle function, pacing-induced cardiomyopathy with left ventricular dilation, and annular dilation. In contrast, biventricular (BiV) pacing may improve MR presumably by opposing the negative effects. Whether or not ...
Zanoni Stephen S Naval Medical Center San Diego, Department of Emergency Medicine, San Diego, - - 2014
Patients who present with recurrent syncope are at risk for having underlying conduction disease, which may worsen if not promptly recognized and treated. We describe a patient who initially presented to a Mexican clinic with recurrent syncope and an electrocardiogram that showed complete heart block. After being transferred to our ...
Schreiber Donald D Division of Emergency Medicine, Stanford University School of Medicine, Stanford, - - 2014
Many emergency department (ED) patients have symptoms that may be attributed to arrhythmias, necessitating outpatient ambulatory cardiac monitoring. Consensus is lacking on the optimal duration of monitoring. We describe the use of a novel device applied at ED discharge that provides continuous prolonged cardiac monitoring. We enrolled discharged adult ED ...
Kristeller Judith L JL Associate Professor, Department of Pharmacy Practice, Wilkes University , Wilkes-Barre, - - 2014
Corticosteroids are commonly used in the peri-operative setting for patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The inflammatory response to CPB is associated with organ dysfunction and increased mortality. Corticosteroids reduce biochemical inflammatory markers associated with CPB, however the impact on clinical outcomes is mixed. The purpose of this ...
de Haas Hans J HJ From Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (H.J.d.H., V.F., J.N.); Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, the Netherlands (H.J.d.H.); Centre for Inherited Cardiovascular Diseases, IRCCS Policlinico San Matteo, Pavia, Italy (E.A.); Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (V.F.); and Departments of Medicine and Radiology, University of Virginia Health System, Charlottesville, VA - - 2014
In almost all cardiac diseases, an increase in extracellular matrix (ECM) deposition or fibrosis occurs, mostly consisting of collagen I. Whereas replacement fibrosis follows cardiomyocyte loss in myocardial infarction, reactive fibrosis is triggered by myocardial stress or inflammatory mediators and often results in ventricular stiffening, functional deterioration, and development of ...
Li Ai-Hsien AH From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.-H.L., P.P.L.); University of Toronto, Heart & Stroke/Lewar Centre of Excellence, Toronto, Ontario, Canada (P.P.L.); University of California, San Diego, School of Medicine (F.J.V., R.A.G.); and Bristol-Myers Squibb Company, Pennington, NJ - - 2014
The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates optimal force transduction, electric transmission, intercellular communication, and metabolic exchange within the myocardial microenvironment. In the setting of increased wall stress, injury, or disease, the ECM ...
Iyer Rugmani Padmanabhan RP From the San Antonio Cardiovascular Proteomics Center and Mississippi Center for Heart Research (R.P.I., L.E.d.C.B., Y.-F.J., M.L.L.) and Department of Biophysics and Physiology (R.P.I., L.E.d.C.B., M.L.L.), University of Mississippi Medical Center, Jackson; Department of Electrical and Computer Engineering, University of Texas at San Antonio (Y.-F.J.); and Research Service, G.V. (Sonny) Department of Physiology and Biophysics, Montgomery Veterans Affairs Medical Center, Jackson, MS - - 2014
The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP ...
Lin Xianhe X Department of Cardiology, Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, - - 2014
Sites of latest mechanical activation (SOLA) have been recognized as optimal left-ventricular (LV) lead positions for cardiac resynchronization therapy (CRT). This study was aimed to investigate SOLA in ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB). Sixty-four consecutive LBBB patients (47 DCM, 17 ICM), ...
Ma Luyao L The First Affiliated Hospital with Nanjing Medical University, Nanjing, People's Republic of - - 2014
Chronic heart failure (CHF) is responsible for significant morbidity and mortality worldwide, mainly as a result of neurohumoral activation. Acupuncture has been used to treat a wide range of diseases and conditions. In this study, we investigated the effects of electroacupuncture (EA) on the sympathetic nerve activity, heart function and ...
Collins Helen E HE University of Alabama at - - 2014
The endoplasmic reticulum (ER) Ca(2+) sensor, stromal interaction molecule 1 (STIM1), has been implicated as a key mediator of store-dependent and store-independent Ca(2+) entry (SOCE) pathways, and maintenance of ER structure. STIM1 is present in embryonic, neonatal and adult cardiomyocytes and has been strongly implicated in hypertrophic signaling; however, the ...
Sen Hanim H Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum, Twente, Enschede, - - 2014
Objective: To assess differences in clinical outcome between complex patients treated with Resolute zotarolimus-eluting stent (ZES) versus Xience V everolimus-eluting stent (EES). Background: Nowadays, many complex patients with coronary disease are treated with percutaneous coronary interventions, using drug-eluting stents (DES). Methods: We analyzed 2-year outcome data of 1033 complex patients ...
Dianat Mahin M Department of Physiology and Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, - - 2014
Although reperfusion is a useful method for the survival of ischemic heart, harmful effects have been observed. This study was carried out to investigate the preconditioning and cardioprotective potential effects of crocin and vitamin E on the hemodynamic and infarct size in the ischemia-reperfusion model of isolated rat hearts. Animals ...
Rafiq Khadija K Temple University School of Medicine, Philadelphia, - - 2014
The proto-oncogene Casitas b-lineage lymphoma (c-Cbl) is an adaptor protein with an intrinsic E3 ubiquitin ligase activity that targets receptor and non-receptor tyrosine kinases, resulting in their ubiquitination and down-regulation. However, the function of c-Cbl in the control of cardiac function is currently unknown. In this study, we examined the ...
Montealegre-Gallegos Mario M Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesia, Hospital México de la Caja Costarricense del Seguro Social, Universidad de Costa Rica, San José, Costa - - 2014
To compare the determination of stroke volume (SV) and cardiac output (CO) using 2-dimensional (2D) versus 3-dimensional (3D) transesophageal echocardiography (TEE). Prospective observational study. Tertiary care university hospital. 35 patients without structural valve abnormalities undergoing isolated coronary artery bypass grafting. Left ventricular outflow tract (LVOT) diameter determined with 2D TEE ...
Chang Hsiao-Chuan HC Department of Biotechnology, Asia University, Taichung 41354, Taiwan, Republic of - - 2014
Previously we found carbon tetrachloride (CCl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis. The purpose of this study is to determine whether further CCl₄ treatment would induce cardiac cell fibrosis. The cardiac tissues were analyzed by H&E. histological staining, Trichrome Masson staining and Western blotting. The results showed that the ...
Sandoval Yader Y Division of Cardiology. Department of Medicine. Hennepin County Medical Center, Minneapolis, MN. Electronic address: - - 2014
Supply/demand (type 2) myocardial infarction is a commonly encountered clinical challenge. It is anticipated that it will be detected more frequently once high-sensitivity cardiac troponin assays are approved for clinical use in the US. We provide a perspective based on available data regarding the definition, epidemiology, etiology, pathophysiology, prognosis, management ...
Li Cui C Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, Heilongjiang 150081, PR - - 2014
Cardiac hypertrophy is a primary predictor of progressive heart disease that often results in heart failure. Growing evidence has demonstrated that microRNAs (miRNAs) play a critical role in regulating cardiac hypertrophy. This study was designed to evaluate the effect of miR-328 on cardiac hypertrophy and the potential molecular mechanisms. We ...
Kruse Jan M JM Abteilung für Nephrologie und Internistische Intensivemdizin, Charité Universitätsmedizin Berlin, Germany. Electronic address: - - 2014
The aim of this study is to evaluate the diagnostic accuracy of the cardiac injury markers troponin (TNT), creatine kinase (CK) and creatine kinase-MB (CK-MB) to diagnose or exclude acute myocardial infarction after cardiac arrest. 226 patients who underwent diagnostic coronary angiography after sudden cardiac arrest were analyzed retrospectively. Levels ...
Sun Shuping S Department of Mechanical Engineering, Yamaguchi University, Tokiwadai 2-16-1, Ube, Yamaguchi, Japan. Electronic address: - - 2014
This paper proposes a novel automatic method for the moment segmentation and peak detection analysis of heart sound (HS) pattern, with special attention to the characteristics of the envelopes of HS and considering the properties of the Hilbert transform (HT). The moment segmentation and peak location are accomplished in two ...
Mownah Omar A OA Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK; Department of Pharmacy, Health and Well-being, University of Sunderland, Sunderland, UK. Electronic address: - - 2014
This study reports on the development of a novel method for achieving ex vivo reanimation of hearts from a porcine donation after circulatory death (DCD) model without the use of donor pretreatment. Porcine hearts (n = 23) were procured 10-29 min after confirmation of asystole. All hearts underwent initial flush with AQIX RS-I solution ...
Kim Yong Sook YS Heart Research Center, Chonnam National University Hospital, Gwangju, South - - 2014
We examined whether a shift in macrophage phenotype could be therapeutic for myocardial infarction (MI). The mouse macrophage cell line RAW264.7 was stimulated with peptidoglycan (PGN), with or without 5-azacytidine (5AZ) treatment. MI was induced by ligation of the left anterior descending coronary artery in rats, and the rats were ...
Fiedler J J Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integrated Research and Treatment Center Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, - - 2014
The pathogenic role of noncoding microRNA (miR, miRNA) has been demonstrated for several disease conditions in the heart. The underlying molecular mechanisms have been deciphered for numerous miRs that are deregulated as a result of cardiac stress. Innovative therapeutic strategies based on antifibrotic, antihypertrophic, or proangiogenic effects of miRNAs are ...
Johnson Amy C AC University of Guelph, - - 2014
Thermal acclimation can alter cardiac function and morphology in a number of fish species, but little is known about the regulation of these changes. The purpose of the current study was to determine how cold acclimation affects zebrafish (Danio rerio) cardiac morphology, collagen composition, and connective tissue regulation. Heart volume, ...
Sedlak Tara T Department of Medicine, Division of Cardiology, Vancouver General Hospital, Vancouver, British Columbia, Canada; Division of Cardiology, University of British Columbia, Vancouver, British Columbia, - - 2014
In women presenting for evaluation of suspected ischemic symptoms, a diagnosis of normal coronary arteries is 5 times more common than it is in men. These women are often labeled as having cardiac syndrome X, and a subset of them have microvascular angina caused by microvascular coronary dysfunction (MCD). MCD ...
Akar Fadi G FG The Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA, - - 2014
In this article, we review recent advances in our understanding of arrhythmia mechanisms in the failing heart. We focus on changes in repolarization, conduction, and intracellular calcium cycling because of their importance to the vast majority of clinical arrhythmias in heart failure. We highlight recent efforts to combat arrhythmias using ...
Zhang Yang - - 2014
Loss of miR-29 is associated with cardiac fibrosis. The present study examined the role and therapeutic potential of miR-29 in mouse model of hypertension induced by AngII. By using miRNA microarray, in situ hybridization, and real-time PCR, we found that AngII-induced cardiac fibrosis in the hypertensive heart and in cultured ...
Cho Yasunori Y Department of Cardiovascular Surgery, Tokai University School of Medicine, Isehara, Kanagawa, - - 2014
The aim of this study was to assess long-term outcomes of non-heart transplant surgical approaches to advanced ischaemic cardiomyopathy (ICM), including left ventricular restoration (LVR) and mitral valve operation. Since September 2002, 102 consecutive patients (mean age 65, 18 females) with advanced ICM [ejection fraction (EF) <40%, left ventricular end-systolic ...
Cherniavsky Alexander A Department of Surgery, Aorta, Coronary and Peripheral Arteries, Novosibirsk Research Institute of Circulation Pathology, Novosibirsk, - - 2014
We report our experience with a modified mini-maze procedure and pulmonary vein isolation using radiofrequency energy for treating persistent atrial fibrillation during coronary artery bypass grafting (CABG). Ninety-five patients with persistent atrial fibrillation and coronary heart disease underwent open heart surgery combined with intraoperative irrigated radiofrequency ablation. Patients were randomized ...
Clayton Benjamin B Cardiology Department, X-Ray East, Derriford Hospital, Plymouth PL6 8DH, - - 2014
The imaging of myocardial disease is of increasing importance for cardiologists from all subspecialties, for diagnosis, risk stratification, or to facilitate therapy. While the gold standard modalities for such assessment are cardiac magnetic resonance and echocardiography, these are not universally suitable. Cardiac computed tomography (CT), well-established for the assessment of ...
Gillmann Hans-Jörg HJ 1Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany. 2Institute of Biostatistics, Hannover Medical School, Hannover, Germany. 3Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany. 4Department of Clinical Chemistry, Hannover Medical School, Hannover, - - 2014
Myocardial infarction after major surgery is frequent, drives outcome, and consumes health resources. Specific prediction and detection of perioperative myocardial infarction is an unmet clinical need. With the widespread use of high-sensitive cardiac troponin T assays, positive tests become frequent, but their diagnostic or prognostic impact is arguable. We, therefore, ...
Sun Hai-Ying HY Departments of Physiology and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Xiamen Heart Center, Zhongshan Hospital, Medical School of Xiamen University, Xiamen 361004, China. - - 2014
Cellular excitability is an important physiological factor in maintaining normal cardiac activity. The present study was designed to investigate the ionic mechanism underlying different excitability in atrial and ventricular myocytes of guinea pig heart using a whole-cell patch configuration. We found that excitability is lower in ventricular myocytes than that ...
Gao Changzhao C Department of Clinical Medicine, School of Clinical Medicine, Jilin University, Changchun, Jilin, People's Republic of - - 2014
Recent studies designed to assess the relationship between aortic compliance and heterogeneity of heart electrical activity has shown that hypertrophy aggravates repolarization disturbances in the myocardium. Numerous mechanisms of electrical instability and inhomogeneity associated with left ventricular hypertrophy are now under investigation. Most of the studies have been found to ...
Doukky Rami - - 2014
Left ventricular diastolic impairment and consequently elevated filling pressure may contribute to stasis leading to left atrial appendage thrombus (LAAT) in nonvalvular atrial fibrillation (AF). We investigated whether transthoracic echocardiographic parameters can predict LAAT independent of traditional clinical predictors. We conducted a retrospective cohort study of 297 consecutive nonvalvular AF ...
Scherübel Susanne S Institute of Biophysics, Medical University of Graz, Harrachgasse 21, A-8010 Graz, - - 2014
Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. The benefits of heart rate reduction by ivabradine during MODS, a selective inhibitor of pacemaker current If, are currently being investigated in the MODIfY clinical trial. As If ...
Badri Marwan M Lankenau Medical Center and Lankenau Institute for Medical - - 2014
A 57-year-old male with history of lung cancer presented with palpitations followed by transient loss of consciousness. He was found to be in monomorphic VT at a rate of 217 bpm with left bundle branch block and a superior leftward axis (Figure 1). This article is protected by copyright. All ...
Dahlqvist Jenny Alenius JA Department of Clinical Sciences, Umeå University, Sweden. Electronic address: - - 2014
Our aim was to evaluate the intermittent use of a handheld ECG system for detecting silent arrhythmias and cardiac autonomic dysfunction in children with univentricular hearts. Twenty-seven patients performed intermittent ECG recordings with handheld devices during a 14-day period. A manual arrhythmia analysis was performed. We analyzed heart rate variability ...
Chang Hung-Yu HY Division of Cardiology, Cheng Hsin General - - 2014
Background: Spectral analysis of the left atrium can identify high dominant frequency (DF) sites, which might play a role in the perpetuation of atrial fibrillation (AF). Furthermore, the role of the cardiac autonomic nervous system (CANS) in the genesis of AF has been demonstrated. The relationship between CANS and the high-DF ...
Riley Paul R - - 2014
Damage to the adult mammalian heart is irreversible, and lost cells are not replaced through regeneration. In neonatal mice, prior to P7, heart tissue can be regenerated after injury; however, the factors that facilitate cardiac regeneration in the neonatal heart are not known. In this issue of the JCI, Aurora ...
McIntyre Stephen D SD School of Mathematics, University of Minnesota, Minneapolis, MN 55455; Biomedical Engineering Department, University of Minnesota, Minneapolis, MN - - 2014
A beat-to-beat alternation in the action potential duration (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation in the whole heart. A common approach for the prediction of alternans is to construct the restitution curve, which is the nonlinear functional relationship between the APD ...
Kai Dan D College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China; NUS Graduate School for Integrative Sciences & Engineering, National University of Singapore, - - 2014
Myocardial infarction (MI) leads to the loss of cardiomyocytes followed by left ventricular (LV) remodeling and cardiac dysfunction. We hypothesize that an elastic, biodegradable nanofibrous cardiac patch loaded with mesenchymal stem cells (MSCs) could restrain LV remodeling and improve cardiac function after MI. Poly(ε-caprolactone) (PCL)/gelatin (PG) nanofibers were fabricated by ...
Aç Kgöz Erefden - - 2014
Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There are reports in the literature addressing ischemia modified albumin (IMA) as an early and useful marker in the diagnosis of ischemic heart events. The aim of this study is to evaluate serum ...
Sakamaki Fumiko F Department of Clinical Laboratory, University of Tsukuba Hospital, Tsukuba, - - 2014
To determine an appropriate M-mode method in assessing left ventricular (LV) dyssynchrony in left bundle branch block (LBBB), and to assess feasibility of the method to predict cardiac resynchronization therapy (CRT) responses. Fifty-one patients with LBBB were enrolled. Among them 31 patients underwent CRT. In addition to original septal to ...
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