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Results 201 - 250 of 7484
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Smigla G G Duke Children's Hospital, Duke University Hospital, Durham, NC, USA - - 2014
del Nido cardioplegia solution (CPS) has been successfully used for myocardial protection in the pediatric population. We propose this solution can be used safely in adult congenital patients. The proposed benefit of this solution is the avoidance of the need for repetitive interruption of the operation to administer multiple doses ...
Grans Camilla Figueiredo CF Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, - - 2014
Background: Although resistance exercise training is part of cardiovascular rehabilitation programs, little is known about its role on the cardiac and autonomic function after myocardial infarction. Objective: To evaluate the effects of resistance exercise training, started early after myocardial infarction, on cardiac function, hemodynamic profile, and autonomic modulation in rats. ...
Porrello Enzo R ER School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, - - 2014
Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved ...
Depta J P JP Washington University School of Medicine, Department of Medicine, St Louis, MO, - - 2014
We examined clinical outcomes with proton pump inhibitors (PPI) use within CYP2C19 genotype groups during clopidogrel treatment following acute myocardial infarction (AMI). 2062 patients were genotyped for CYP2C19*2 and *17 variants in TRIUMPH. 12 month clinical outcomes were analyzed among patients discharged on clopidogrel within CYP2C19*2 carrier, CYP2C19*17 carrier, and ...
Legutko Jacek J Department of Interventional Cardiology, University Hospital, Krakow. - - 2014
The growing penetration of mechanical reperfusion in ST-elevation myocardial infarction (STEMI) has been achieved by creation of new percutaneous coronary intervention (PCI) centers which helped shorten time delays but compromised PCI volume. To compare outcomes in STEMI patient treated in PCI centers with or without surgical back-up. Data concerning 1650 ...
Truong Quynh A QA Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, New York; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
A significant minority of patients receiving cardiac resynchronization therapy (CRT) remain non-responsive to this intervention. To determine whether coronary sinus (CS) or baseline peripheral venous (PV) levels of established and emerging heart failure (HF) biomarkers are predictive of CRT outcomes. In 73 patients (age 68±12; 83% male; ejection fraction 27±7%) ...
Iyer A A The Victor Chang Cardiac Research Institute, Sydney, Australia; Heart and Lung Transplant Unit, St. Vincent's Hospital, Darlinghurst, Australia; Department of Cardiothoracic Surgery, St. Vincent's Hospital, Darlinghurst, - - 2014
Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts. We used a porcine asphyxia model to evaluate viability of DCD hearts subjected to warm ischemic times (WIT) of 20-40 min prior to flushing with Celsior (C) solution. We then assessed potential benefits of supplementing C with erythropoietin, ...
Banshodani Masataka M Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital 3-30, Nakajimacho, Naka-ku, Hiroshima - - - 2014
Increased vascular access flow after percutaneous transluminal angioplasty (PTA) for central venous stenosis and occlusion (central venous disease, CVD) can affect cardiac function in hemodialysis (HD) patients. We evaluated the cardiac function, etiology, and treatment in HD patients with CVD. HD patients with CVD treated by PTA between June 2006 ...
Lima Aline Regina Ruiz AR Internal Medicine Department, Botucatu Medical School - UNESP, Botucatu, SP, - - 2014
Background: Intracellular signaling pathways involved in skeletal myosin heavy chain (MyHC) isoform alterations during heart failure (HF) are not completely understood. We tested the hypothesis that diaphragm expression of mitogen-activated protein kinases (MAPK) and myogenic regulatory factors is changed in rats with myocardial infarction (MI) induced HF. Methods: Six months ...
Udink Ten Cate Floris E A FE Department of Pediatric Cardiology, Heart Center Cologne, University Hospital of Cologne, Cologne, Germany. Electronic address: - - 2014
The 12-lead surface electrocardiogram is a valuable and feasible clinical tool in the management of patients following tetralogy of Fallot (TOF) repair. The importance of QRS duration in TOF patients has long been acknowledged. A prolonged QRS complex has been associated with increased risk for subsequent life-threatening ventricular arrhythmia and ...
Börekçi Abdurrezzak A aDepartment of Cardiology, School of Medicine, Kafkas University, Kars bDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana cDepartment of Internal Medicine, Mersin State Hospital, Mersin, - - 2014
Epicardial adipose tissue is related to coronary atherosclerosis, left ventricle hypertrophy, myocardial dysfunction, cardiomyopathy, and inflammation, which produces a variety of cytokines that influence key pathogenic mechanisms of atherogenesis. The main goal of this study is to examine the relationship between epicardial fat thickness (EFT) and cardiovascular risk markers as ...
Baruteau J J Metabolic Medicine Department, Great Ormond Street Hospital, London, UK. Electronic address: - - 2014
Dilated cardiomyopathy is a rare complication in propionic acidaemia (PA). Underlying pathophysiological mechanisms are poorly understood. We present a child of Pakistani consanguineous parents, diagnosed with late-onset PA at 18months of age. He presented a mild phenotype, showed no severe further decompensations, normal growth and psychomotor development on a low ...
Yang Xin-Wei XW Center of Arrhythmia Diagnosis and Treatment, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
Fragmented QRS (fQRS) marks inhomogeneous activation and asynchronous cardiac contraction. It has been proved that cardiac resynchronization therapy (CRT) could reverse geometrical remodeling as well as correct electrical dyssynchrony. We aimed to investigate whether fQRS changed corresponding to the therapeutic response to CRT. Patients who underwent de novo CRT implantation ...
Martinez Sara C SC Cardiovascular Division, Department of Internal Medicine, School of Medicine, Washington University, Saint Louis, - - 2014
Electrocardiograms (ECGs) are routinely obtained in patients with advanced congestive heart failure (CHF) before and after surgical implantation with a left-ventricular assist device (LVAD). As the number of patients with CHF is increasing, it is necessary to characterize the changes present in the ECG of patients with LVADs. ECGs of ...
Celikyurt Umut U Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, - - 2014
Cardiac resynchronization therapy (CRT) has been recommended for patients with symptomatic heart failure and a wide QRS. Fragmented QRS (fQRS) on a 12-lead electrocardiography (ECG) has been shown to predict cardiac events. We aimed to investigate the relationship between resolution of fQRS and response to CRT. Sixty-seven consecutive patients (38 ...
Sano Makoto M Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, - - 2014
Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, ...
Osaki Satoru S Division of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis. Electronic address: - - 2014
To investigate the resuscitation potential and contractile function in adult human donation after cardiac death (DCD) hearts by ex vivo perfusion. With institutional review board approval and under the DCD protocol at the University of Wisconsin (UW) Organ Procurement Organization, 5 brain dead (BD) and 5 DCD donor hearts were evaluated. ...
Mochizuki Yasuhide Y Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of - - 2014
Background:Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to the patient's response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, are also influential.Methods and Results:We studied 132 patients undergoing CRT. LV dyssynchrony was determined by anteroseptal-to-posterior wall delay on the mid-LV short-axis view using ...
Quatre A A Department of internal medicine, North Hospital, chemin des Bourrely, 13015 Marseille, France. Electronic address: - - 2014
We report the results of combining cardiac and hepatic MRI in the same examination to monitor 48 multi-transfused patients presenting iron overload secondary to their transfusions. This cardiac MRI technique uses acquisition sequences and calculation software that are readily available for 1.5 T systems, and it has been validated to ...
Metelka Rudolf R Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech - - 2014
Backround. The autonomic nervous system is one of the major homeostatic regulatory systems of the body. Detection of cardiac autonomic neuropathy (CAN), reflected by reduced heart rate variability (HRV), is an independent adverse prognostic factor: sympathovagal balance failure with a sympathetic dominance is the main trigger for lethal arrhythmias and ...
Jing Linyuan L Departments of Pediatrics, Physiology, Biomedical Engineering and Medicine, University of Kentucky, UK Chandler Hospital, 741 S Limestone, BBSRB B353, Lexington, KY 40536, - - 2014
Patients with repaired tetralogy of Fallot (rTOF) frequently have right bundle branch block. To better understand the contribution of cardiac dyssynchrony to dysfunction, we developed a method to quantify left (LV), right (RV), and inter-ventricular dyssynchrony using standard cine cardiac magnetic resonance (CMR). Thirty patients with rTOF and 17 healthy ...
Espinoza Andreas W AW The Intervention Centre and Department of Cardiology, Rikhospitalet, Institute for Clinical Medicine, University of Oslo, N-0424, Oslo, - - 2014
The aim of this PhD thesis was to provide a continuous method to monitor myocardial function during cardiac surgery with the superior sensitivity of ultrasonic technique and the continuity of electrocardiographic (ECG) monitoring. An ultrasound system with epicardial transducers was provided, presenting real-time M-mode LV wall images. In two experimental ...
Kim So-Sun SS College of Nursing, Nursing Policy Research Institute, Yonsei University, Seoul, - - 2014
The purpose of this study was to develop a comprehensive cardiac rehabilitation program that considered patients' learning needs and cultural context, and to identify the impact of this program on patients with coronary heart disease in Korea. We employed a quasi-experimental design to evaluate the effects of the developed program ...
Vizzardi Enrico E Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, - - 2014
Obstructive sleep apnoea-hypopnoea (OSAH) is a prevalent condition characterized by repetitive pharyngeal collapse during sleep, leading to hypoxemia, hypercapnia, and persistent inspiratory efforts against an occluded airway until arousal. Several studies demonstrated that OSAH exerts acute and chronic effects on the cardiovascular system. Thus, although being a respiratory problem, the ...
Wang Man M Department of Ultrasound in Medicine, Shanghai Sixth People Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, - - 2014
Coronary artery disease is a common cardiovascular disease that often causes myocardial infarction (MI), which, after a certain period, can develop into congestive heart failure, resulting in high mortality and mortality rates. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) has recently been considered a final common effector in myocardial ...
Sousa Pedro Alexandre PA Serviço de Cardiologia, Hospital de Faro, E.P.E., Faro, Portugal. Electronic address: - - 2014
Congenitally corrected transposition of the great arteries is a rare heart defect that can be associated with systemic ventricular dysfunction and conduction disturbances. The use of cardiac resynchronization therapy in patients with congenital heart disease is not fully established. The authors report a case of cardiac resynchronization therapy in a ...
Carrasco-Sánchez Francisco Javier FJ Internal Medicine Department, Complejo Hospitalario de Huelva, Hospital Juan Ramón Jiménez, Ronda Norte s/n 21005, Huelva, Spain, - - 2014
Galectin-3 is a soluble β-galactoside-binding lectin released by activated cardiac macrophages. Elevated levels of galectin-3 have been found to be associated with adverse outcomes in patients with heart failure. A number of recent studies suggest that galectin-3 may provide relevant information regarding the pathophysiologic process of heart failure. We analyzed ...
Coppo Simone S Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, - - 2014
To test the hypothesis that intervals with superior beat-to-beat coronary artery repositioning precision exist in the cardiac cycle, to design a coronary MR angiography (MRA) methodology in response, and to ascertain its performance. Coronary repositioning precision in consecutive heartbeats was measured on x-ray coronary angiograms of 17 patients and periods ...
Torregrosa Isidro I Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain, - - 2014
Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early ...
Cowling Randy T RT UCSD - - 2014
The discoidin domain receptor 2 (DDR2) is a fibrillar collagen receptor that is expressed in mesenchymal cells throughout the body. In the heart it is selectively expressed on cardiac fibroblasts. We generated a germline DDR2 knockout mouse and used this mouse to examine the role of DDR2 deletion on heart ...
Sojka Stephen S University of North Carolina McAllister Heart Institute, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, USA Department of Biology, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, - - 2014
The identification and characterization of the cellular and molecular pathways involved in the differentiation and morphogenesis of specific cell types of the developing heart are crucial to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor ...
Zheng Yi Y Biomedical Information Technology Lab, the University of Aizu, Tsuruga, Ikki-machi, Aizu-Wakamatsu, Fukushima 965-8580, - - 2014
The action potential duration (APD) and the conduction velocity (CV) restitution have been reported to be important in the maintenance and conversion of ventricular fibrillation (VF), whose mechanisms remain poorly understood. Multiple-wavelet and/or mother-rotor have been regarded as the main VF mechanisms, and APD restitution (APDR) and CV restitution (CVR) ...
Paul Arghya - - 2014
The objective of this study was to develop an injectable and biocompatible hydrogel which can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial growth factor-165 (VEGF) pro-angiogenic gene for myocardial therapy. For the study, an efficient non-viral gene delivery system using polyethylenimine (PEI) functionalized GO nanosheets (fGO) ...
Dorbala Sharmila S Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division and Cardiac Amyloidosis Program, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
The purpose of this study was to test the hypothesis that coronary microvascular function is impaired in subjects with cardiac amyloidosis. Effort angina is common in subjects with cardiac amyloidosis, even in the absence of epicardial coronary artery disease (CAD). Thirty-one subjects were prospectively enrolled in this study, including 21 ...
Vilahur Gemma G Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, - - 2014
Studies in patients support a beneficial effect of statin treatment early after acute coronary syndrome and/or prior percutaneous coronary intervention. However, statin effect during total occlusion remains unknown. To investigate whether infusion of activated simvastatin during ischemia and prior reperfusion and oral administration thereafter confers cardioprotection and improves cardiac healing ...
Krämer Johannes J Department of Internal Medicine I, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University of Würzburg, Würzburg, - - 2014
The aim of this study was to investigate the impact of myocardial fibrosis in Fabry disease. Seventy-three patients with genetically confirmed Fabry disease were followed for 4.8 ± 2.4 years. In accordance with current guidelines, 57 patients received enzyme replacement therapy (ERT) after study inclusion, whereas 16 did not. At baseline ...
Yang Tao T Department of Cardiovascular and Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
An increasing number of studies have demonstrated the critical role of microRNAs in the pathogenesis of cardiac hypertrophy and dysfunction. This study evaluated whether miR-214 plays a pivotal role in the development of cardiac hypertrophy and heart failure. In human tissues, miR-214 overexpression was determined to promote cardiac hypertrophy. We ...
Kaschina Elena E Center for Cardiovascular Research, Charité - Medical Faculty Berlin, Hessische Str. 3-4, 10115, Berlin, Germany, - - 2014
The angiotensin AT2-receptor mediates tissue protective actions. Its regenerative potential has been tested in multiple disease models including models of myocardial infarction. These studies used different experimental approaches in order to detect AT2-receptor-related effects such as AT2-receptor deficiency or overexpression, treatment with an AT1-receptor blocker leading to indirect stimulation of ...
Bennett Noel M NM From the *Keck School of Medicine of the University of Southern California; and †Department of Radiology, LAC+USC Medical Center, Los Angeles, - - 2014
Diastolic dysfunction is commonly associated with heart failure with preserved systolic function. Diastolic abnormality includes progressively impaired left ventricle (LV) relaxation, followed by pseudonormal mitral inflow pattern with Valsalva enhancement, and finally restrictive LV filling. Diastolic dysfunction may lead to left atrial dilatation with consequent atrial fibrillation. Gated myocardial perfusion ...
Andersen Mads J MJ The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, - - 2014
Heart failure (HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in western countries. Approximately one-half of patients with HF have preserved ejection fraction (HFpEF). In contrast to HF with reduced EF (HFrEF), there is no proven effective treatment for ...
Kolte Dhaval D From the *Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY; †Scottsdale Healthcare, Scottsdale Cardiovascular Center, Scottsdale, AZ; and ‡Department of Medicine & Pharmacology, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, - - 2014
Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular ...
Díaz Olga M Seco OM Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA - - 2014
Objective-To determine prevalence of myocardial injury in horses with colic on the basis of high concentrations of cardiac troponin I (cTnI), frequency of cardiac arrhythmias within the first 24 to 48 hours after hospital admission or surgery because of colic, and associations between high cTnI concentrations and cardiac arrhythmias, clinical ...
García-Prieto Jaime J Imaging, Epidemiology and Atherothrombosis Department, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, - - 2014
Selective stimulation of β3 adrenergic-receptor (β3AR) has been shown to reduce infarct size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term effect and the cardioprotective mechanisms at the level of cardiomyocytes have not been elucidated, and the impact of β3AR stimulation has not been evaluated in a ...
Hong Kyung U KU Institute of Molecular Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY, 40202, USA, - - 2014
The discovery of adult cardiac stem cells (CSCs) and their potential to restore functional cardiac tissue has fueled unprecedented interest in recent years. Indeed, stem-cell-based therapies have the potential to transform the treatment and prognosis of heart failure, for they have the potential to eliminate the underlying cause of the ...
Tadros Rafik R Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Québec, Canada; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Québec, - - 2014
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in epidemiologic and investigative studies as well as in daily patient care. At the supraventricular level, women are at increased risk of sick sinus syndrome and atrioventricular (AV) node re-entrant tachycardia, whereas men manifest more AV block and accessory pathway-mediated ...
Lee Hye Young HY Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ; Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, - - 2014
Recent studies show positive association of early repolarization (ER) with the risk of life-threatening arrhythmias in patients with coronary artery disease (CAD). This study was to investigate the relationships of ER with myocardial scarring and prognosis in patients with CAD. Of 570 consecutive CAD patients, patients with and without ER ...
Duerr Georg D GD Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, - - 2014
Ischemic heart disease is associated with inflammation, interstitial fibrosis and ventricular dysfunction prior to the development of heart failure. Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be involved, but their potential role in cardioprotection is not well understood. We therefore explored the role of the cannabinoid receptor ...
Beake Matthew Jonathan MJ 1Neonatal Unit,Birmingham Women's Hospital NHS Trust,Birmingham,United - - 2014
A preterm 29-week gestation baby was delivered because of gross foetal hydrops secondary to congenital complete heart block. Despite a poor prognosis, she survived stabilisation and received emergency epicardial pacing followed by permanent pacemaker insertion on day 13, weighing 1.2 kg.
Qi Dake - - 2014
The cellular response to stress involves the recruitment and coordination of molecular signaling pathways that prevent cell death. D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic substrates in mammalian cells, but shares partial sequence and structural homology with macrophage migration inhibitory factor (MIF). Here, we observed that DDT is ...
Güder Gülmisal G Comprehensive Heart Failure Center, University of Würzburg, Würzburg, - - 2014
Heart failure and COPD are very common in the elderly. As both syndromes share common risk factors, such as tobacco smoking, and pathophysiological pathways, including systemic inflammation and activation of the neurohumoral system, they frequently coincide. Because of the similar clinical presentation, diagnoses of COPD in the presence of heart ...
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