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Results 201 - 250 of 7320
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Hidestrand Pip M PM Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI, USA - - 2014
We present a patient with complex single ventricle physiology who was subsequently diagnosed with atresia of the coronary sinus ostium in the setting of myocardial dysfunction following operative palliation. Although a rare cardiac defect, awareness is important as the coronary venous system will often drain to a left superior vena ...
Liu Xiaoyu X From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.); and Institute of Molecular Medicine, Peking University, Beijing, China - - 2014
Studies have reported that development of congestive heart failure is associated with increased endoplasmic reticulum stress. Double stranded RNA-activated protein kinase R-like endoplasmic reticulum kinase (PERK) is a major transducer of the endoplasmic reticulum stress response and directly phosphorylates eukaryotic initiation factor 2α, resulting in translational attenuation. However, the physiological ...
Shigeru Mayumi M aDepartment of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine bKobe University Graduate School of Health Sciences, Kobe cHyogo Brain and Heart Center, Himeji, - - 2014
A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between Tc-tetrofosmin (Tc-TF) myocardial scintigraphy and the response to CRT. Twenty-one patients ...
Arking Dan E DE 1] Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. - - 2014
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to ...
Waksmonski Carol A CA Columbia University Medical Center, 630 West 168th St, New York, NY 10032. Electronic address: - - 2014
There are multiple imaging modalities available for the assessment of pregnant women with known or suspected cardiac disease. Because of its safety and general availability, echocardiography is the preferred study of choice for the evaluation of ventricular function, valvular heart disease, congenital heart disease, evaluation of the aorta, and the ...
Chowdhury Arpita A Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, - - 2014
The cardiac extracellular matrix (ECM) undergoes a dynamic transition following myocardial infarction. Fibulin-6, an ECM protein is expressed in cell junctions particularly in tissues subjected to significant mechanical stress. Fibulin-6 deficiency results in defective cell migration in nematodes and early embryonic lethality in mice. The role of fibulin-6 in healthy ...
Cai Benzhi B Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, - - 2014
Our in vitro studies revealed that a transcription factor, Forkhead box protein O1 (FoxO1), negatively regulates the expression of NaV1.5, a main α subunit of the cardiac Na(+) channel, by altering the promoter activity of SCN5a in HL-1 cardiomyocytes. The in vivo role of FoxO1 in the regulation of cardiac ...
Rordorf Roberto R Department of Cardiology, IRCCS Fondazione Policlinico S. - - 2014
Background:Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated whether pro-inflammatory cytokines might predict the response to cardiac resynchronization therapy (CRT).Methods and Results:Plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 were assessed in 91 patients before CRT. Response to CRT was defined ...
Wang Lina L Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, - - 2014
Studies from our group and others have indicated that paracrine function is one of major mechanisms underlying stem cell-mediated cardioprotection. To improve therapeutic efficacy of cardiac stem cells (CSCs), modification of CSCs to enhance their paracrine actions is of great interest. We have shown previously that stem cells from female ...
Al Mohani Ghaliah G Arrhythmology and Electrophysiology, Centro Cardiologico Monzino, IRCCS, Via C Parea n. 4, 20138, Milan, Italy, - - 2014
Electrical storm (ES) is one of the most challenging clinical scenarios facing electrophysiologists, and in certain settings emergency ablation should be performed. The majority of ES occurs in patients with structural heart disease, predominantly coronary heart disease and nonischemic heart disease like right ventricular arrhythmogenic dysplasia and previous myocarditis as ...
Czompa Attila A Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, - - 2014
Cardiovascular diseases are primary cause of death worldwide, particularly among populations with sedentary lifestyles and diets rich in animal products and processed foods. Currently, public health countermeasures to these disorders focus on costly and often marginally effective interventions administered only after the development of disease. These countermeasures are mainly palliative ...
Drury Nigel E NE Department of Cardiothoracic Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, UK School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, - - 2014
Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome. In a prospective, randomized, ...
Ito Kohei K Department of Biological Information, Tokyo Institute of Technology, Yokohama, - - 2014
Background: Zebrafish have the ability for heart regeneration. However, another teleost animal model, the medaka, had not yet been investigated for this capacity. Results: Compared with zebrafish, the medaka heart responded differently to an injury: An excessive fibrotic response occurred in the medaka heart; and existing cardiomyocytes or cardiac progenitor ...
Armenian Saro H SH Population Sciences, City of Hope - - 2014
Purpose: To examine the utility and reliability of obtaining early echocardiographic measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac injury in asymptomatic childhood cancer survivors at risk for LV dysfunction and congestive heart failure due to past exposure to anthracycline chemotherapy. Experimental Design: Using a ...
Yasui Haruyo H Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, - - 2014
Engineering of three-dimensional (3D) cardiac tissues using decellularized extracellular matrix could be a new technique to create an "organ-like" structure of the heart. To engineer artificial hearts functionally comparable to native hearts, however, much remain to be solved including stable excitation-propagation. To elucidate the points, we examined conduction properties of ...
Boudoulas Konstantinos Dean KD Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, - - 2014
Studies of left atrial (LA) function, until the latter part of the 20th century, were mostly limited to experimental animal models and to studies related to clinical research in the cardiac catheterization laboratory. For this reason, LA function has received considerably less attention than left ventricular (LV) functions, even though ...
Moon Jeonggeun J Division of Cardiology, Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Republic of - - 2014
Objectives: To identify differences in cardiac hemodynamic changes between the Valsalva maneuver and nitroglycerin (NTG) administration. Methods: Fifty-three subjects (37 men, 43 ± 12 years) with normal cardiac function [left ventricular ejection fraction ≥55%, early to late mitral inflow velocity ratio (E/A) ≥1, left atrial volume index ≤34 ml/m(2) and ...
Zhao Lei L Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Rd Beijing, - - 2014
To evaluate the accuracy of multidetector computed tomography (MDCT) in assessing myocardial delayed enhancement and left ventricle wall thickness in hypertrophic cardiomyopathy (HCM) compared with cardiac magnetic resonance (CMR) as the reference standard. Eighty consecutive patients (59 male; 53.2±13.0 years) were examined with MDCT, followed by CMR 1 day later. ...
Liu Chia-Ying CY Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, - - 2014
Cardiac magnetic resonance (CMR) is a standard of reference for cardiac structure and function. Recent advances in T1 mapping and spectroscopy also provide assessment of myocardial tissue composition. However, the reference ranges of left ventricular parameters have rarely been assessed in an African-American (AA) population without known cardiac disease. To ...
Zhang Ling X LX Brown Medical - - 2014
We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts. Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) ...
Chisholm Gro E GE Department of Cardiology, Aarhus University Hospital, Denmark - - 2014
The safety of therapeutic hypothermia combined with percutaneous coronary intervention (PCI) after out-of-hospital cardiac arrest has been challenged after reports of high risk of stent thrombosis. We searched the Western Denmark Heart Registry to identify patients with an acute coronary angiography due to out-of-hospital cardiac arrest performed at our institution ...
Facchini Emanuela E Department of Translational Medicine, Clinical Cardiology, Università del Piemonte Orientale, Azienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, - - 2014
The left atrial cavity has recently been identified as a potential biomarker for cardiac and cerebrovascular accidents. This review examines the potential of left atrial size and function in predicting cardiovascular disease in the general population and outcomes in coronary artery disease (CAD) patients. The atrium is perfused primarily by ...
Bursac Nenad - - 2014
Cardiac fibroblasts have been long recognized as active participants in heart disease; however, their exact physiological and pathological roles remain elusive, mainly due to the lack of specific markers. In this issue of the JCI, Moore-Morris and colleagues used a fibroblast-specific collagen1a1-GFP reporter to demonstrate that fibroblast accumulation after aortic ...
Higgins Peter P From the College of Medical, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences (P.H., J.D., P.W.M., K.M., P.L., K.R.L.), Gardiner Institute, Western Infirmary (P.H., J.D., K.M., K.R.L.), Glasgow Royal Infirmary (P.W.M., P.L.), University of Glasgow, Glasgow, United Kingdom. - - 2014
Extended cardiac monitoring immediately after acute ischemic stroke (AIS) increases paroxysmal atrial fibrillation (PAF) detection, but its reliability for detection or exclusion of longer term paroxysmal PAF is unknown. We evaluated the positive and negative predictive value (PPV and NPV) of AF detection early after AIS, for PAF confirmation 90 ...
Stoyanov Nik N Arrhythmia Service, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada K1Y - - 2014
The aetiology of atrial arrhythmias in the otherwise healthy and young is usually unrecognized. We hypothesized that rare cases of atrial arrhythmias in the young may represent the initial manifestation of a muscular dystrophy syndrome. We describe the clinical characteristics, disease progression, results of electrophysiological study, and genetic findings in ...
Sastry Priya P Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, - - 2014
Mesenteric ischaemia (MesI) remains a rare but lethal complication following cardiac surgery. Previously identified risk factors for MesI mortality (age, poor left ventricular (LV) function, cardiopulmonary bypass time and blood loss) are non-specific and cannot necessarily be modified. This study aims to identify potentially modifiable risk factors for MesI mortality ...
Weltman Nathan Y NY Department of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South - - 2014
Thyroid dysfunction is common in individuals with diabetes mellitus (DM) and may contribute to the associated cardiac dysfunction. However, little is known about the extent and pathophysiological consequences of low thyroid conditions on the heart in DM. DM was induced in adult female SD rats by injection of nicotinamide (N; ...
Nemes Attila A 2nd Department of Medicine and Cardiology Centre, Medical Faculty,Albert Szent-Györgyi Clinical Center,University of - - 2014
Left ventricular twist results from the movement of two orthogonally oriented muscular bands of the helical myocardial structure, with a consequent clockwise rotation of the left ventricular base and counterclockwise rotation of the left ventricular apex. To the best of the authors' knowledge, this is the first time that left ...
Düngen Hans-Dirk HD Charité Universitätsmedizin Berlin, Department of Internal Medicine-Cardiology, Berlin, - - 2014
Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved heart rate after BB optimization on long-term ...
Hibbert Benjamin B Division of Cardiology (Hibbert, Hayley, Beanlands, Le May, Davies, So, Marquis, Labinaz, Froeschl, O'Brien, Burwash, Wells, Pourdjabbar, Simard, Glover), Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ont.; Libin Cardiovascular Institute (O'Brien), Calgary, Alta.; Division of Hematology (Atkins), Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, - - 2014
Small studies have yielded divergent results for administration of granulocyte colony-stimulating factor (G-CSF) after acute myocardial infarction. Adequately powered studies involving patients with at least moderate left ventricular dysfunction are lacking. Patients with left ventricular ejection fraction less than 45% after anterior-wall myocardial infarction were treated with G-CSF (10 5g/kg ...
Tao Hui H Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Fu Rong Road, Hefei, Anhui 230601, China; Cardiovascular Research Center, Anhui Medical University, Hefei 230601, - - 2014
Cardiac fibrosis contributes to the pathogenesis of atrial fibrillation (AF). The molecular mechanisms underlying the cardiac fibrosis remain unclear. However, Ras association domain family 1 isoform A (RASSF1A) is a regulatory tumor suppressor, which is important for pathogenesis of cardiac fibrosis and fibroblasts activation. Moreover, DNA methylation plays a central ...
Martínez Juana J Juana Martínez, César Ramón, Julio Pascual, Germán Morís, Neurology Department, Hospital Universitario Central Asturias, 33006 Oviedo, - - 2014
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that almost exclusively involves motor neurons although autonomic dysfunction has also been reported. We present an 84-year-old female with no documented history of heart disease, who was admitted with negative T waves in the electrocardiogram precordial leads mimicking myocardial ischaemia. No ...
Beavers David L DL Cardiovascular Research Institute Translational Biology and Molecular Medicine - - 2014
Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal cardiac function. In a little over a decade, junctophilin-2 (JPH2) has become recognized as a cardiac structural protein critical in forming junctional membrane complexes (JMCs) which are subcellular domains essential for excitation-contraction coupling within the heart. While initial studies ...
Nchimi Alain A Department of Medical Imaging, University Hospital of Liège (CHU), GIGA Cardiovascular Sciences, Domaine Universitaire du Sart Tilman B35, 4000, Liège, Belgium, - - 2014
Flow and pressure variations cause potential changes in magnetic resonance imaging (MRI) signal intensity across the cardiac cycle. Nevertheless, cardiac dynamic contrast-enhanced (perfusion) MRI is performed and analyzed regardless of the cardiac phase. We investigate whether the cardiac phase impacts myocardial and left ventricle (LV) cavity time intensity curves (TICs) ...
MacColl Christine E CE Fetal Cardiac Program, Labatt Family Heart Centre, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada, - - 2014
Factors associated with in utero fetal demise (IUFD) of fetuses that have underlying cardiac pathologies are largely unknown. This case-control study aimed to define the prevalence of IUFD in fetuses with a diagnosis of cardiac pathologies and to identify prenatal predictors of IUFD. Between January 2004 and December 2010, 74 ...
Argulian Edgar - - 2014
Heart failure with preserved ejection fraction has become a fashionable diagnosis. An increasing number of elderly patients with dyspnea carries this diagnosis. Evaluation and management of these patients typically labeled as having 'diastolic' heart failure are challenging and misconceptions are common. No drug class has been consistently shown to provide ...
Acampa Wanda W Institute of Biostructure and Bioimaging, National Council of Research, Naples, - - 2014
The prognostic value of normal stress myocardial perfusion single-photon emission computed tomography (MPS) in patients with diabetes has only been evaluated in single-center studies of relatively limited sample size. We performed a meta-analysis of published studies, including diabetic patients with known or suspected coronary artery disease (CAD), to assess the ...
Dai Dao-Fu DF Department of Pathology, University of Washington School of Medicine, Seattle, WA, - - 2014
Chronic right heart failure predisposes to hepatic passive congestion and centrizonal necrosis that may lead to hepatic fibrosis (cardiac sclerosis). Although there have been several studies on the histologic features of congestive hepatopathy, there is no available grading system. In this study we developed a novel grading system for congestive ...
Xing Daniel T DT The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia, - - 2014
Heart failure (HF) is associated with a large increase in cardiac sympathetic nerve activity (CSNA), which has detrimental effects on the heart and promotes arrhythmias and sudden death. There is increasing evidence that arterial chemoreceptor activation plays an important role in stimulating renal SNA (RSNA) and muscle SNA in HF. ...
Streiff Cole C Pediatric Cardiology, Oregon Health & Science University, Portland, - - 2014
Quantitative left ventricular mass (LVM) as well as regional strain values may be obtained from full-volume real time 3D echocardiography data via semi-automated feature tracking and represent indices of heart function, both in health and disease. Fresh adult porcine and ovine hearts were passively pumped to simulate normal cardiac motion ...
Mewton Nathan N aHôpital Cardiovasculaire Louis Pradel, Department of Intensive and Coronary Care, Hospices Civils de Lyon, Bron bDepartment of Biostatistics, Hospices Civils de Lyon, Université Claude Bernard Lyon, Lyon cHôpital Cardiovasculaire Louis Pradel, Centre d'Investigation CliniqueUnité INSERM 1407 dHôpital Cardiovasculaire Louis Pradel, Department of Radiology, Hospices Civils de Lyon, Bron, - - 2014
The relationship of cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) with myocardial biomarkers and markers of inflammation in acute viral myocarditis is not clearly defined. We assessed the relationship of LGE with myocardial and inflammatory biomarkers measured during the acute phase of myocarditis and their predictive value on clinical ...
Smiley Dia D Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, College of Medicine, Cincinnati, - - 2014
The cardiac regenerative capacity of MRL/MpJ mouse remains a controversy. Although the MRL mouse has been reported to exhibit minimal scarring and subsequent cardiac regeneration after cryoinjury of the right ventricle, multiple studies have been unable to replicate this cardiac regenerative capacity after both cryogenic and coronary ligation cardiac injury. ...
Sohal Manav M Division of Imaging Sciences and Biomedical Engineering, King's College London, London, UK, - - 2014
Septal flash (SF) describes early inward motion of the ventricular septum in patients with left bundle branch block (LBBB), and correction corresponds to increased response to cardiac resynchronization therapy (CRT). SF has traditionally been assessed by echocardiography. We sought to determine if cardiac magnetic resonance (CMR) imaging could identify SF ...
Schidlow David N DN Department of Cardiology, Boston Children's Hospital, Boston, - - 2014
Introduction Prenatal diagnosis provides valuable information regarding a variety of congenital heart defects. Some defects occur early in gestation with little change throughout pregnancy, whereas others evolve during mid and late gestation. Fetal cardiac intervention (FCI) affords the opportunity to interrupt progression of disease in this latter category, resulting in improved ...
Krieger Eric V EV Division of Cardiology, Department of Medicine, Seattle Adult Congenital Heart Service, University of Washington Medical Center and Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, - - 2014
Heart failure (HF) is the leading cause of death in adults with repaired congenital heart disease (CHD). However there is currently little evidence to guide treatment strategies in this growing group of patients. Unlike the majority of HF, which is usually caused by LV systolic or diastolic dysfunction, CHD-HF is ...
Hee Leia L Cardiology Department, Liverpool Hospital, Sydney, New South Wales, Australia; South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, - - 2014
Patients with CKD have increased cardiovascular morbidity and mortality. This study investigated the prognostic value of common clinical echocardiographic parameters.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: There were 289 unselected consecutive patients who had a transthoracic echocardiogram between January and June 2003. Patients with stage 3 or 4 CKD (n=49) were compared ...
Olsen P P Department of Applied Sciences and Allied Health, Christchurch Polytechnic Institute of Technology, New Zealand - - 2014
The relationship between watching major sporting events and cardiac hospital admissions is contentious. This study is the first to investigate cardiovascular admissions during Rugby World Cup (RWC) tournaments. New Zealand (NZ) public hospital admissions data were analysed for cardiovascular events during the 1999, 2003, 2007 and 2011 RWC tournaments. The ...
Sousa Carla C Serviço de Cardiologia, Centro Hospitalar São João, E.P.E., Porto, Portugal. Electronic address: - - 2014
Post-cardiac injury syndrome (PCIS) is an inflammatory process involving the pericardium secondary to cardiac injury. It can develop after cardiac trauma, cardiac surgery, myocardial infarction, and, rarely, after certain intravascular procedures. We report a rare case of an iatrogenic cardiac rupture followed by PCIS with delayed inflammatory pericardial effusion after ...
Cabanelas Nuno N Serviço de Cardiologia, Hospital de Santarém, Santarém, Portugal. Electronic address: - - 2014
The demonstrated benefits of cardiac resynchronization therapy (CRT) in reducing mortality and hospitalizations for heart failure, improving NYHA functional class and inducing reverse remodeling have led to its increasing use in clinical practice. However, its potential contribution to complex ventricular arrhythmias is controversial.We present the case of a female patient ...
Aleong Ryan G RG University of Colorado, Division of Cardiology. Electronic address: - - 2014
Atrial Fibrillation and heart failure with reduced left ventricular ejection fraction have interrelated pathophysiologies. New onset atrial fibrillation in heart failure patients has been associated with increased mortality, but has not been definitively related to clinical heart failure progression. To test the hypothesis that new onset atrial fibrillation is related ...
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