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Results 201 - 250 of 7383
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Baysa A A University of Oslo, Institute of Basic Medical Sciences (IMB), Department of Physiology, Oslo, - - 2014
Heart failure is a growing problem worldwide. Cardiac remodeling, which features aseptic inflammation, metalloproteinase (MMP) activation and induction of matricellular proteins, contributes to heart failure progression after myocardial infarction (MI). The ShcA gene encodes three isoforms: p46-, p52- and p66ShcA, which are crucial for embryonic development of the heart. The ...
Lucas A A Inserm-UPS U1048, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse, - - 2014
Postinfarction remodeling is accompanied and influenced by perturbations in oxidative stress status and MAPK signaling. The Growth arrest and DNA-damage-inducible 45 (Gadd45) proteins are small acidic proteins involved in modulation of MAPK activities. Despite its relationship with p38 MAPK and intense interest in the cancer field, little is known about ...
Skyschally A A University of Essen Medical School, Institute for Pathophysiology, Essen, - - 2014
Remote ischemic preconditioning (RIPC), i.e. brief episodes of ischemia/reperfusion in a remote organ, protects the heart against infarction after myocardial ischemia/reperfusion. However, the transfer of protection from the remote ischemic/reperfused organ to the heart is still not understood. Here we address the transfer of a blood-borne cardioprotective factor from a ...
Van Hout G P J GP University Medical Center Utrecht, Division Heart and Lungs, Experimental Cardiology, Utrecht, - - 2014
Revascularization after myocardial infarction (MI) induces a strong inflammatory response resulting in an increase of circulating neutrophils. Neutrophil quantities have found to be a good predictor for future adverse events. In this study, we hypothesized that the extent of morphological changes in circulating neutrophils also reflects the myocardial damage after ...
Horckmans M M Ludwig-Maximilians University, Institute for Cardiovascular Prevention (IPEK), Munich, - - 2014
Neutrophils contribute to tissue damage after acute myocardial ischemia and reperfusion, but their role in infarct healing is less well understood. Because neutrophil-derived granule proteins mediate classical monocyte recruitment in acute inflammation, we hypothesized that neutrophil depletion during the acute inflammatory phase will improve infarct healing by reducing the proinflammatory ...
Van Lier Mgjtb M Academic Medical Center of Amsterdam, Department of Biomedical Engineering & Physics, Amsterdam, - - 2014
Myocardial tissue ischemia may be mitigated by a well-developed coronary collateral circulation. Only few detailed 3D data are available of the entire human coronary arterial tree. Here, high-resolution reconstructions of the coronary vasculature of two human hearts were quantitatively analyzed. Two hearts became available through autopsy: heart #1 (64 years, ...
Gonzalez Tendero A A Hospital Clinic, IDIBAPS, Department of Maternal-Fetal Medicine, Barcelona, - - 2014
Intrauterine growth restriction (IUGR) is associated with prenatal changes in cardiac shape and function that persist in childhood and may be associated to an increased cardiovascular mortality in adulthood. Ultrasound and MRI provide information at organ level, but their resolution is too low. Microscopy provides detail at cellular and subcellular ...
Fernandez-Jimenez R R National Centre for Cardiovascular Research (CNIC), Epidemiology, Atherothrombosis and Imaging Department, Madrid, - - 2014
Myocardial infarct size estimation using biomarkers -creatine kinase (CK) and troponin (cTn) - is commonly used as the primary endpoint in many experimental studies and clinical trials. We recently described for the first time in a retrospective study that peak of cTnI could overestimate infarct size in presence of left ...
Avolio E E University of Udine, Department of Medical and Biological Sciences, Udine, - - 2014
Cellular senescence associated with ageing and disease hampers the functional properties of human c-Kit+ Cardiac Stem Cells (CSC) in vitro. Aim of the study was to identify molecular mechanisms associated with CSC senescence and to pharmacologically modulate this latter, at the aim to improve the therapeutic potential of CSC in ...
Iaccarino D D University of Padova, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Padua, - - 2014
The gene Coiled Coil Domain Containing 80 (Ccdc80) is highly expressed in the hearts of vertebrates and its role is well defined in tumor suppression, glucose homeostasis and adipocyte differentiation. Our aims are to define its functional role during embryonic development and in cardiomyopathies. We used 3 different models: 1. ...
Kulaveerasingam D D King's College London, Randall Division of Cell and Molecular Biophysics, London, United - - 2014
Hypertrophy and hyperplasia play key roles in the growth of heart muscle. Following formation of the zebrafish heart tube at one day post fertilisation (dpf), it is currently thought that cell addition at the poles of the heart, with little proliferation of cardiomyocytes, results in growth until 2 dpf. From ...
Perez-Pomares J M JM University of Málaga, Málaga, - - 2014
Myocardial infarction is a prevalent cardiovascular disease. Mechanisms of repair in the post-infarcted heart include a progressive fibrosis that severely affects cardiac performance, eventually leading to cardiac failure. Cardiac fibrosis in the context of ventricular remodeling after infarction depends on fibroblasts of the cardiac interstitium (cardiac fibroblasts), a heterogeneous population ...
Constantin M M Electrophysiology and Heart modeling Institute (IHU-Liryc), Inserm U1045, University of Bordeaux, Pessac-Bordeaux, - - 2014
Cardiac gap junctions display distinct electrical properties in the different tissues that ensure the coordinated propagation of the action potential. They are clusters of intercellular gap junction channels (GJC) composed of connexins (Cxs) Cx40, Cx43, Cx45 and Cx30.2, which exhibit specific pattern of expression in the healthy heart. Importantly, in ...
Miskolczi G G University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have evidence that rapid cardiac pacing preserves gap junction (GJ) function by preventing the structural alterations that occur during ischaemia, 24h later; a mechanism which play a role the pacing-induced delayed protection against arrhythmias. Purpose: The present study has now examined whether closing of GJs prior to ischaemia with ...
Revnic C R CR C.C.Iliescu Cardiology Dpt, Bucharest, - - 2014
Heart muscle is largely dependent on uninterrupted blood flow, which guarantees delivery of substrates and washout of harmful products of metabolism. During aging, a lot of degenerative changes occur at the levels of all organs and heart is not an exception. Ischemia is a frequent phenomenon associated with aging and ...
Gonczi M M University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have previously reported that rapid cardiac pacing preserves the function of gap junction channels (GJ) during ischaemia and reperfusion, 24h later. This result has suggested a role for these channels in the delayed antiarrhythmic protection. The present study was designed to provide further evidence to this relationship using carbenoxolone ...
Louwe Mc M Leiden University Medical Center, Dept. Endocrinology and Metabolic Diseases, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, - - 2014
Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signalling domain that competitively inhibits TLR4-signalling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signalling, would lead ...
Baranyai T T Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, - - 2014
Remote ischemic preconditioning (RIPC) of the heart (i.e. brief ischemia/reperfusion cycles, subjected to a remote organ or a remote area, reduce the consecutive damage of a sustained cardiac ischemia. Although, its mechanism has been investigated thoroughly, exact interorgan transfer mechanisms of cardioprotection by RIPC are required to be further investigated. ...
Ciccarelli M M University of Salerno, Salerno, - - 2014
Heart Failure (HF) is a complex disease characterized by progressive cardiac dilation and loss of ATP content needed to accomplish myocardial contractile function. GRK2 is a serine/threonine kinase that phosphorylates and binds receptors coupled to G proteins, such as β-adrenergic receptors (βAR) and it is involved in the pathophysiology of ...
Radovits T T Semmelweis University, Heart and Vascular Center, Budapest, - - 2014
Pathological cardiac hypertrophy is observed in pressure overload of the left ventricle. Elevated intracellular cGMP-levels have been reported to prevent the development of pathological myocardial hypertrophy. We investigated the effects of chronic activation of the cGMP producing enzyme, soluble guanylate cyclase (sGC) by cinaciguat in a rat model of pressure ...
Perea Gil I I Health Research Institute Germans Trias, Badalona, - - 2014
Cardiac tissue engineering emerges as a promising alternative to current therapies addressed to myocardial infarction. In this context, we aimed to obtain and characterize myocardial bioprosthesis based on a decellularized matrix capable of being engrafted in damaged myocardium. Myocardial blocks (3x3 cm), differentiating epicardial, mesocardial and endocardial regions, were obtained ...
Singh Kuljit K Department of Cardiology, Queen Elizabeth Hospital, Adelaide, Australia. Electronic address: - - 2014
Takotsubo cardiomyopathy (TTC) is often associated with hypotension and shock. However, development of hypotension/shock in TTC is not closely related to extent of left ventricular (LV) hypokinesis. We sought to determine whether additional right ventricular (RV) involvement in TTC might contribute to hypotension and shock development and thus to prolonged ...
Cervellin Gianfranco G Emergency Department, Academic Hospital of Parma, Parma, - - 2014
The history of myocardial infarction (MI) diagnostics has gone through a continuous evolution over the past century, when several new discoveries have contributed to remarkably increase the number of patients appropriately diagnosed with this condition. The tale "of MIs and Men" displays rather a long history, since atherosclerosis was found ...
Lima-Leopoldo Ana Paula AP Federal University of Espirito Santo - - 2014
Few studies have evaluated the relationship between the duration of obesity, cardiac function and the proteins involved in myocardial calcium (Ca(2+)) handling. We hypothesized that long-term obesity promotes cardiac dysfunction due to a reduction of expression and/or phosphorylation of myocardial Ca(2+)-handling proteins. Thirty-day-old male Wistar rats were distributed into two ...
Lip Gregory Yh GY City Hospital, Birmingham, United Kingdom & Aalborg University, Aalborg, Denmark - - 2014
Advances in pharmacological and devices therapy have greatly improved prognosis in patients with systolic heart failure. Despite this congestive heart failure still bears a very grim prognosis, particularly in patients with more advances stages of the disease that are so frequently seen on hospital wards. Which pathogenic pathways may need ...
Ferrari Roberto R Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy - - 2014
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that ...
Peng Ying Y UW-Madison, United - - 2014
Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often precipitated by myocardial infarction (MI). However, the molecular changes driving cardiac dysfunction immediately after MI remain poorly understood. Myofilament proteins, responsible for cardiac contraction and relaxation, play critical roles in signal reception and transduction ...
Stallone Fabio F Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland Department of Cardiology, University Hospital Basel, Basel, - - 2014
Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. A total of 984 ...
Gorjup Vojka V Vojka Gorjup, Marko Noc, Peter Radsel, Department of Intensive Internal Medicine, University Medical Center Ljubljana, 1000 Ljubljana, - - 2014
Coronary artery disease is the most frequent cause of sudden cardiac death. There is general consensus that immediate coronary angiography with percutaneous coronary intervention (PCI) should be performed in all conscious and unconscious patients with ST-elevation myocardial infarction in post-resuscitation electrocardiogram. In these patients acute coronary thrombotic lesion ("ACS" lesion) ...
Malfitano Christiane C Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, - - 2014
While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease (IHD), animal data have so far pointed to a lower probability of IHD. Thus, the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned ...
Zhao Zhi-Gang ZG Intensive Care Unit, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, - - 2014
Embelin has been used to treat fever and inflammatory diseases for thousands of years. Although reports indicate that embelin has antiinflammatory effects, its effects on myocardial injury following cardiac arrest (CA) have not been previously explored. In this study, we aim to investigate the protective effects of embelin on myocardial ...
Karmali Kunal N KN Departments of Preventive Medicine and Medicine (Cardiology), Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, USA, - - 2014
Cardiac rehabilitation is an important component of recovery from coronary events but uptake and adherence to such programs are below recommended levels. In 2010, our Cochrane review identified some evidence that interventions to increase uptake of cardiac rehabilitation can be effective but there was insufficient evidence to provide recommendations on ...
Prunet Bertrand - - 2014
Although aneurysmal subarachnoid hemorrhage (SAH) is often complicated by myocardial injury, whether this neurogenic cardiomyopathy is associated with the modification of cardiac metabolism is unknown. This study sought to explore, by positron emission tomography/computed tomography, the presence of altered cardiac glucose metabolism after SAH. During a 16-month period, 30 SAH ...
Boopathy Archana V AV Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown promising outcomes. Notch1 signaling plays a critical role in cardiac development and in the survival, cardiogenic lineage commitment, and differentiation of cardiac stem/progenitor cells. In this study, we functionalized ...
de Waha Suzanne - - 2014
This study aimed to evaluate the incremental prognostic value of infarct size, microvascular obstruction (MO), myocardial salvage index (MSI), and left ventricular ejection fraction (LV-EFCMR) assessed by cardiac magnetic resonance imaging (CMR) in comparison to traditional outcome markers in patients with ST-elevation myocardial infarction (STEMI) reperfused by primary percutaneous intervention ...
Ganapathi Asvin M AM Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, - - 2014
Patients with thoracic aortic disease undergoing thoracic endovascular aortic repair (TEVAR) often have concomitant coronary artery disease and are at risk for perioperative adverse cardiac events. Despite this risk, the need for and extent of preoperative cardiac workup before TEVAR remain undefined. This study seeks to assess the adequacy of a ...
Borlaug Barry A BA The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, - - 2014
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials ...
Hatipoglu Suzan S Department of Cardiology, Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey, - - 2014
In the absence of mitral valve disease left atrial (LA) volume is a marker of diastolic dysfunction and its severity. This study investigated the relationship between left ventricular (LV) end diastolic pressure (LVEDP) and LA volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (RT3DE), in a ...
Myers J A JA Triangle Veterinary Referral Hospital, Raleigh, - - 2014
Information regarding cardiac changes in domestic cats with acromegaly is limited. The objective of this study was to describe the echocardiographic findings in cats with acromegaly. Eighteen cats diagnosed with acromegaly at Colorado State University between 2008 and 2012. Of these 18 cats, 11 had echocardiography performed. A retrospective review ...
Umoh Nsini A NA Department of Physiology & Biophysics, College of Medicine, Howard University, Washington, District of - - 2014
Clinical manifestations of alcohol abuse on the cardiac muscle include defective contractility with the development of heart failure. Interestingly, low alcohol consumption has been associated with reduced risk of cardiovascular disease. Although several hypotheses have been postulated for alcoholic cardiomyopathy and for the low-dose beneficial cardiovascular effects, the precise mechanisms ...
Zhang Yixuan Y UCLA, United - - 2014
Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked upregulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation (AF), which is accompanied by overproduction of reactive oxygen species (ROS). In the present study we investigated impact ...
Taggart Peter P The Heart Hospital, University College London, UK. Electronic address: - - 2014
Understanding the mechanisms of fatal ventricular arrhythmias is of great importance. In view of the many electrophysiological differences that exist between animal species and humans, the acquisition of basic electrophysiological data in the intact human heart is essential to drive and complement experimental work in animal and in-silico models. Over ...
Varvarousi Giolanda G University of Athens, Medical School, Greece, 75 Mikras Asias street, 11527, Athens, - - 2014
Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent benefits for long-term survival or favourable neurologic outcome. Levosimendan ...
Hatam Nima - - 2014
Disturbances of interatrial conduction have been proposed as one of the contributing mechanisms of postoperative atrial fibrillation (AF). P-wave dispersion has been recognized as a sensitive tool for detecting interatrial conduction disturbances. Doppler myocardial imaging (DMI) has been validated as a non-invasive tool to indirectly reflect electrical atrial activation and ...
Gournay Véronique V CHU de Nantes, Service de Cardiologie Pédiatrique, Nantes, France. Electronic address: - - 2014
The number of children in need of mechanical circulatory support has increased substantially over the last two decades, due to the technological progress made in surgery and intensive care, leading to improved survival of patients with congenital heart disease. In addition, primary myocardial dysfunction related to myocarditis or dilated cardiomyopathy ...
Vecchiati Alessandra A Alessandra Vecchiati, Sara Tellatin, Annalisa Angelini, Sabino Iliceto, Francesco Tona, Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, 35128 Padova, - - 2014
Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy (CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening ...
Zong Nobel N The NHLBI Proteomics Center at UCLA; Departments of Physiology and Medicine/Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, - - 2014
Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets poly-ubiquitinated proteins for destruction, it itself is modifiable by ubiquitination. We aim to identify the exact ubiquitination sites on cardiac proteasomes and examine whether they are also subject to acetylations. Assembled cardiac 20S proteasome complexes were purified from ...
Gupta Saurabh Kumar SK Department of Cardiology, All India Institute of Medical Sciences, New Delhi, - - 2014
Atrial inversion (or mirror-imaged atrial arrangement) occurring in isolation, that is, without corresponding mirror imagery of the viscera, has been previously shown with discordant atrioventricular connections resulting in transposition physiology. We hereby report a case of "isolated atrial inversion" wherein atrioventricular connections were concordant owing to the presence of criss-crossing ...
Hidestrand Pip M PM Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI, USA - - 2014
We present a patient with complex single ventricle physiology who was subsequently diagnosed with atresia of the coronary sinus ostium in the setting of myocardial dysfunction following operative palliation. Although a rare cardiac defect, awareness is important as the coronary venous system will often drain to a left superior vena ...
Liu Xiaoyu X From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.); and Institute of Molecular Medicine, Peking University, Beijing, China - - 2014
Studies have reported that development of congestive heart failure is associated with increased endoplasmic reticulum stress. Double stranded RNA-activated protein kinase R-like endoplasmic reticulum kinase (PERK) is a major transducer of the endoplasmic reticulum stress response and directly phosphorylates eukaryotic initiation factor 2α, resulting in translational attenuation. However, the physiological ...
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