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Results 201 - 250 of 7492
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Carlomagno Guido G aDepartment of Cardiology, Monaldi Hospital, AORN Ospedali dei Colli bDepartment of Translational Medical Sciences, Federico II University cUnit of Cardiology, Loreto Mare Hospital dSecond University of Naples, Monaldi Hospital, AORN Ospedali dei Colli, Naples, - - 2014
Intraventricular dyssynchrony has traditionally been studied by means of contraction delays between different myocardial segments. Recently, the discoordination of opposing wall contraction throughout the cardiac cycle has been proposed as a more faithful predictor of response. Aim of the current study was to evaluate which parameters - mechanical dyssynchrony or ...
Lomivorotov Vladimir V VV Departments of Anaesthesiology and Intensive Care. Electronic address: - - 2014
To test the hypothesis that perioperative OMEGA-3 polyunsaturated fatty acid infusion would reduce the incidence of postoperative atrial fibrillation in patients after coronary artery bypass grafting as assessed by an implantable continuous cardiac monitor. Prospective, randomized, double-blind, placebo-controlled study. Tertiary cardiothoracic referral center. Thirty-nine patients with coronary artery disease who ...
Ozsu Savas S Pulmonary Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, - - 2014
Soluble urokinase plasminogen activator receptor (suPAR) is a newly discovered inflammatory biomarker. suPAR has not been previously studied in differentiating non-cardiac pleural effusion from cardiac pleural effusions. The aim of our study was to assess the diagnostic value of suPAR in pleural effusion (PF). The concentration of PF suPAR was ...
Kim Jiwon J Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, - - 2014
Left ventricular (LV) remodeling and myocardial fibrosis have been linked to adverse heart failure outcomes. Mid wall late gadolinium enhancement (MW-LGE) on cardiac magnetic resonance (CMR) imaging is well-associated with non-ischemic cardiomyopathy (NICM), but prevalence in ischemic cardiomyopathy (ICM) and association with remodeling are unknown. The population comprised patients with ...
Akat Kemal Marc KM Laboratory of RNA Molecular Biology,Howard Hughes Medical Institute, The Rockefeller University, New York, NY - - 2014
Heart failure (HF) is associated with high morbidity and mortality and its incidence is increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic and therapeutic applications, respectively. We determined myocardial and circulating miRNA abundance and its changes in patients with stable and end-stage HF before and at different ...
Pozo Eduardo E The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, New York, USA Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, Madrid, - - 2014
Cardiac amyloidosis (CA) is associated with typical morphological features on echocardiography, including concentric LV hypertrophy (LVH). Cardiac magnetic resonance (CMR) can accurately depict anatomy in different cardiomyopathies. Our aim was to describe the morphological features and remodelling patterns of CA with CMR, and establish their diagnostic accuracy, as well as ...
Senel Ayaz H Gözde HG Drexel University, School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA 19104, USA. Electronic address: - - 2014
For patients with end-stage heart disease, the access to heart transplantation is limited due to the shortage of donor organs and to the potential for rejection of the donated organ. Therefore, current studies focus on bioengineering approaches for creating biomimetic cardiac patches that will assist in restoring cardiac function, by ...
Abdoli Abas A Department of Mechanical and Materials Engineering, MAIDROC Laboratory, Florida International University, Miami, FL, 33174, USA. - - 2014
The main objective of this work was to demonstrate computationally that realistic human hearts can be cooled much faster by performing conjugate heat transfer consisting of pumping a cold liquid through the cardiac chambers and major veins while keeping the heart submerged in cold gelatin filling a cooling container. The ...
Burrell Lance D LD Intermountain Heart Institute, Intermountain Medical Center, Murray, - - 2014
We report the successful biopsy of a right atrial fatty mass using CARTO 3-dimensional electro-anatomic mapping fused with cardiac MRI. Fluoroscopic guidance within the cardiac chambers lacks precision and therefore risks geographical miss of the intended target and cardiac perforation. CARTO mapping fused with cardiac MRI facilitated precise navigation of ...
Li Ming M Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, - - 2014
Thyroid hormone is a critical regulator of cardiac growth and development, both in fetal life and postnatally. Here we review the role of thyroid hormone in postnatal cardiac development, given recent insights into its role in stimulating a burst of cardiomyocyte proliferation in the murine heart in preadolescence; a response ...
Goodwill Adam G AG Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 46202-5111, USA, - - 2014
This study examined the cardiovascular effects of GLP-1 (7-36) or (9-36) on myocardial oxygen consumption, function and systemic hemodynamics in vivo during normal perfusion and during acute, regional myocardial ischemia. Lean Ossabaw swine received systemic infusions of saline vehicle or GLP-1 (7-36 or 9-36) at 1.5, 3.0, and 10.0 pmol/kg/min in ...
Smigla G G Duke Children's Hospital, Duke University Hospital, Durham, NC, USA - - 2014
del Nido cardioplegia solution (CPS) has been successfully used for myocardial protection in the pediatric population. We propose this solution can be used safely in adult congenital patients. The proposed benefit of this solution is the avoidance of the need for repetitive interruption of the operation to administer multiple doses ...
Grans Camilla Figueiredo CF Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, - - 2014
Background: Although resistance exercise training is part of cardiovascular rehabilitation programs, little is known about its role on the cardiac and autonomic function after myocardial infarction. Objective: To evaluate the effects of resistance exercise training, started early after myocardial infarction, on cardiac function, hemodynamic profile, and autonomic modulation in rats. ...
Porrello Enzo R ER School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, - - 2014
Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved ...
Borisenko Oleg O From *Synergus AB, Danderyd, Sweden; †Scottish Extracorporeal Life Support Service, Royal Hospital for Sick Children, Glasgow, the United Kingdom; ‡ Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, the United Kingdom; §Synergus AB, Danderyd, and Medical Management Centre, Department of Learning Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; ¶Paediatric and Neonatal ECMO Service, Freeman Hospital, Newcastle upon Tyne, the United Kingdom; & Department of Cardiothoracic Transplant, Wythenshawe Hospital, Manchester, the United Kingdom; and #Emeritus Cardiothoracic Surgeon, Glenfield General Hospital, Leicester, the United - - 2014
The aim of the study was to systematically evaluate effect of CentriMag heart pump (Thoratec Corporation, Pleasanton, CA, USA) as temporary ventricular assist device (VAD) and part of extra corporeal membrane oxygenation (ECMO) system on outcomes in patients with cardiac or cardiac-respiratory failure. A systematic search was conducted in five ...
Depta J P JP Washington University School of Medicine, Department of Medicine, St Louis, MO, - - 2014
We examined clinical outcomes with proton pump inhibitors (PPI) use within CYP2C19 genotype groups during clopidogrel treatment following acute myocardial infarction (AMI). 2062 patients were genotyped for CYP2C19*2 and *17 variants in TRIUMPH. 12 month clinical outcomes were analyzed among patients discharged on clopidogrel within CYP2C19*2 carrier, CYP2C19*17 carrier, and ...
Legutko Jacek J Department of Interventional Cardiology, University Hospital, Krakow. - - 2014
The growing penetration of mechanical reperfusion in ST-elevation myocardial infarction (STEMI) has been achieved by creation of new percutaneous coronary intervention (PCI) centers which helped shorten time delays but compromised PCI volume. To compare outcomes in STEMI patient treated in PCI centers with or without surgical back-up. Data concerning 1650 ...
Truong Quynh A QA Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, New York; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
A significant minority of patients receiving cardiac resynchronization therapy (CRT) remain non-responsive to this intervention. To determine whether coronary sinus (CS) or baseline peripheral venous (PV) levels of established and emerging heart failure (HF) biomarkers are predictive of CRT outcomes. In 73 patients (age 68±12; 83% male; ejection fraction 27±7%) ...
Iyer A A The Victor Chang Cardiac Research Institute, Sydney, Australia; Heart and Lung Transplant Unit, St. Vincent's Hospital, Darlinghurst, Australia; Department of Cardiothoracic Surgery, St. Vincent's Hospital, Darlinghurst, - - 2014
Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts. We used a porcine asphyxia model to evaluate viability of DCD hearts subjected to warm ischemic times (WIT) of 20-40 min prior to flushing with Celsior (C) solution. We then assessed potential benefits of supplementing C with erythropoietin, ...
Banshodani Masataka M Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital 3-30, Nakajimacho, Naka-ku, Hiroshima - - - 2014
Increased vascular access flow after percutaneous transluminal angioplasty (PTA) for central venous stenosis and occlusion (central venous disease, CVD) can affect cardiac function in hemodialysis (HD) patients. We evaluated the cardiac function, etiology, and treatment in HD patients with CVD. HD patients with CVD treated by PTA between June 2006 ...
Lima Aline Regina Ruiz AR Internal Medicine Department, Botucatu Medical School - UNESP, Botucatu, SP, - - 2014
Background: Intracellular signaling pathways involved in skeletal myosin heavy chain (MyHC) isoform alterations during heart failure (HF) are not completely understood. We tested the hypothesis that diaphragm expression of mitogen-activated protein kinases (MAPK) and myogenic regulatory factors is changed in rats with myocardial infarction (MI) induced HF. Methods: Six months ...
Udink Ten Cate Floris E A FE Department of Pediatric Cardiology, Heart Center Cologne, University Hospital of Cologne, Cologne, Germany. Electronic address: - - 2014
The 12-lead surface electrocardiogram is a valuable and feasible clinical tool in the management of patients following tetralogy of Fallot (TOF) repair. The importance of QRS duration in TOF patients has long been acknowledged. A prolonged QRS complex has been associated with increased risk for subsequent life-threatening ventricular arrhythmia and ...
Börekçi Abdurrezzak A aDepartment of Cardiology, School of Medicine, Kafkas University, Kars bDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana cDepartment of Internal Medicine, Mersin State Hospital, Mersin, - - 2014
Epicardial adipose tissue is related to coronary atherosclerosis, left ventricle hypertrophy, myocardial dysfunction, cardiomyopathy, and inflammation, which produces a variety of cytokines that influence key pathogenic mechanisms of atherogenesis. The main goal of this study is to examine the relationship between epicardial fat thickness (EFT) and cardiovascular risk markers as ...
Baruteau J J Metabolic Medicine Department, Great Ormond Street Hospital, London, UK. Electronic address: - - 2014
Dilated cardiomyopathy is a rare complication in propionic acidaemia (PA). Underlying pathophysiological mechanisms are poorly understood. We present a child of Pakistani consanguineous parents, diagnosed with late-onset PA at 18months of age. He presented a mild phenotype, showed no severe further decompensations, normal growth and psychomotor development on a low ...
Yang Xin-Wei XW Center of Arrhythmia Diagnosis and Treatment, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
Fragmented QRS (fQRS) marks inhomogeneous activation and asynchronous cardiac contraction. It has been proved that cardiac resynchronization therapy (CRT) could reverse geometrical remodeling as well as correct electrical dyssynchrony. We aimed to investigate whether fQRS changed corresponding to the therapeutic response to CRT. Patients who underwent de novo CRT implantation ...
Martinez Sara C SC Cardiovascular Division, Department of Internal Medicine, School of Medicine, Washington University, Saint Louis, - - 2014
Electrocardiograms (ECGs) are routinely obtained in patients with advanced congestive heart failure (CHF) before and after surgical implantation with a left-ventricular assist device (LVAD). As the number of patients with CHF is increasing, it is necessary to characterize the changes present in the ECG of patients with LVADs. ECGs of ...
Celikyurt Umut U Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, - - 2014
Cardiac resynchronization therapy (CRT) has been recommended for patients with symptomatic heart failure and a wide QRS. Fragmented QRS (fQRS) on a 12-lead electrocardiography (ECG) has been shown to predict cardiac events. We aimed to investigate the relationship between resolution of fQRS and response to CRT. Sixty-seven consecutive patients (38 ...
Sano Makoto M Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, - - 2014
Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, ...
Osaki Satoru S Division of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis. Electronic address: - - 2014
To investigate the resuscitation potential and contractile function in adult human donation after cardiac death (DCD) hearts by ex vivo perfusion. With institutional review board approval and under the DCD protocol at the University of Wisconsin (UW) Organ Procurement Organization, 5 brain dead (BD) and 5 DCD donor hearts were evaluated. ...
Mochizuki Yasuhide Y Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of - - 2014
Background:Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to the patient's response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, are also influential.Methods and Results:We studied 132 patients undergoing CRT. LV dyssynchrony was determined by anteroseptal-to-posterior wall delay on the mid-LV short-axis view using ...
Quatre A A Department of internal medicine, North Hospital, chemin des Bourrely, 13015 Marseille, France. Electronic address: - - 2014
We report the results of combining cardiac and hepatic MRI in the same examination to monitor 48 multi-transfused patients presenting iron overload secondary to their transfusions. This cardiac MRI technique uses acquisition sequences and calculation software that are readily available for 1.5 T systems, and it has been validated to ...
Metelka Rudolf R Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech - - 2014
Backround. The autonomic nervous system is one of the major homeostatic regulatory systems of the body. Detection of cardiac autonomic neuropathy (CAN), reflected by reduced heart rate variability (HRV), is an independent adverse prognostic factor: sympathovagal balance failure with a sympathetic dominance is the main trigger for lethal arrhythmias and ...
Jing Linyuan L Departments of Pediatrics, Physiology, Biomedical Engineering and Medicine, University of Kentucky, UK Chandler Hospital, 741 S Limestone, BBSRB B353, Lexington, KY 40536, - - 2014
Patients with repaired tetralogy of Fallot (rTOF) frequently have right bundle branch block. To better understand the contribution of cardiac dyssynchrony to dysfunction, we developed a method to quantify left (LV), right (RV), and inter-ventricular dyssynchrony using standard cine cardiac magnetic resonance (CMR). Thirty patients with rTOF and 17 healthy ...
Espinoza Andreas W AW The Intervention Centre and Department of Cardiology, Rikhospitalet, Institute for Clinical Medicine, University of Oslo, N-0424, Oslo, - - 2014
The aim of this PhD thesis was to provide a continuous method to monitor myocardial function during cardiac surgery with the superior sensitivity of ultrasonic technique and the continuity of electrocardiographic (ECG) monitoring. An ultrasound system with epicardial transducers was provided, presenting real-time M-mode LV wall images. In two experimental ...
Kim So-Sun SS College of Nursing, Nursing Policy Research Institute, Yonsei University, Seoul, - - 2014
The purpose of this study was to develop a comprehensive cardiac rehabilitation program that considered patients' learning needs and cultural context, and to identify the impact of this program on patients with coronary heart disease in Korea. We employed a quasi-experimental design to evaluate the effects of the developed program ...
Vizzardi Enrico E Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, - - 2014
Obstructive sleep apnoea-hypopnoea (OSAH) is a prevalent condition characterized by repetitive pharyngeal collapse during sleep, leading to hypoxemia, hypercapnia, and persistent inspiratory efforts against an occluded airway until arousal. Several studies demonstrated that OSAH exerts acute and chronic effects on the cardiovascular system. Thus, although being a respiratory problem, the ...
Wang Man M Department of Ultrasound in Medicine, Shanghai Sixth People Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, - - 2014
Coronary artery disease is a common cardiovascular disease that often causes myocardial infarction (MI), which, after a certain period, can develop into congestive heart failure, resulting in high mortality and mortality rates. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) has recently been considered a final common effector in myocardial ...
Sousa Pedro Alexandre PA Serviço de Cardiologia, Hospital de Faro, E.P.E., Faro, Portugal. Electronic address: - - 2014
Congenitally corrected transposition of the great arteries is a rare heart defect that can be associated with systemic ventricular dysfunction and conduction disturbances. The use of cardiac resynchronization therapy in patients with congenital heart disease is not fully established. The authors report a case of cardiac resynchronization therapy in a ...
Carrasco-Sánchez Francisco Javier FJ Internal Medicine Department, Complejo Hospitalario de Huelva, Hospital Juan Ramón Jiménez, Ronda Norte s/n 21005, Huelva, Spain, - - 2014
Galectin-3 is a soluble β-galactoside-binding lectin released by activated cardiac macrophages. Elevated levels of galectin-3 have been found to be associated with adverse outcomes in patients with heart failure. A number of recent studies suggest that galectin-3 may provide relevant information regarding the pathophysiologic process of heart failure. We analyzed ...
Coppo Simone S Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, - - 2014
To test the hypothesis that intervals with superior beat-to-beat coronary artery repositioning precision exist in the cardiac cycle, to design a coronary MR angiography (MRA) methodology in response, and to ascertain its performance. Coronary repositioning precision in consecutive heartbeats was measured on x-ray coronary angiograms of 17 patients and periods ...
Torregrosa Isidro I Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain, - - 2014
Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early ...
Cowling Randy T RT UCSD - - 2014
The discoidin domain receptor 2 (DDR2) is a fibrillar collagen receptor that is expressed in mesenchymal cells throughout the body. In the heart it is selectively expressed on cardiac fibroblasts. We generated a germline DDR2 knockout mouse and used this mouse to examine the role of DDR2 deletion on heart ...
Sojka Stephen S University of North Carolina McAllister Heart Institute, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, USA Department of Biology, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, - - 2014
The identification and characterization of the cellular and molecular pathways involved in the differentiation and morphogenesis of specific cell types of the developing heart are crucial to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor ...
Zheng Yi Y Biomedical Information Technology Lab, the University of Aizu, Tsuruga, Ikki-machi, Aizu-Wakamatsu, Fukushima 965-8580, - - 2014
The action potential duration (APD) and the conduction velocity (CV) restitution have been reported to be important in the maintenance and conversion of ventricular fibrillation (VF), whose mechanisms remain poorly understood. Multiple-wavelet and/or mother-rotor have been regarded as the main VF mechanisms, and APD restitution (APDR) and CV restitution (CVR) ...
Paul Arghya - - 2014
The objective of this study was to develop an injectable and biocompatible hydrogel which can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial growth factor-165 (VEGF) pro-angiogenic gene for myocardial therapy. For the study, an efficient non-viral gene delivery system using polyethylenimine (PEI) functionalized GO nanosheets (fGO) ...
Dorbala Sharmila S Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division and Cardiac Amyloidosis Program, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
The purpose of this study was to test the hypothesis that coronary microvascular function is impaired in subjects with cardiac amyloidosis. Effort angina is common in subjects with cardiac amyloidosis, even in the absence of epicardial coronary artery disease (CAD). Thirty-one subjects were prospectively enrolled in this study, including 21 ...
Vilahur Gemma G Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, - - 2014
Studies in patients support a beneficial effect of statin treatment early after acute coronary syndrome and/or prior percutaneous coronary intervention. However, statin effect during total occlusion remains unknown. To investigate whether infusion of activated simvastatin during ischemia and prior reperfusion and oral administration thereafter confers cardioprotection and improves cardiac healing ...
Krämer Johannes J Department of Internal Medicine I, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Center, University of Würzburg, Würzburg, - - 2014
The aim of this study was to investigate the impact of myocardial fibrosis in Fabry disease. Seventy-three patients with genetically confirmed Fabry disease were followed for 4.8 ± 2.4 years. In accordance with current guidelines, 57 patients received enzyme replacement therapy (ERT) after study inclusion, whereas 16 did not. At baseline ...
Yang Tao T Department of Cardiovascular and Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
An increasing number of studies have demonstrated the critical role of microRNAs in the pathogenesis of cardiac hypertrophy and dysfunction. This study evaluated whether miR-214 plays a pivotal role in the development of cardiac hypertrophy and heart failure. In human tissues, miR-214 overexpression was determined to promote cardiac hypertrophy. We ...
Kaschina Elena E Center for Cardiovascular Research, Charité - Medical Faculty Berlin, Hessische Str. 3-4, 10115, Berlin, Germany, - - 2014
The angiotensin AT2-receptor mediates tissue protective actions. Its regenerative potential has been tested in multiple disease models including models of myocardial infarction. These studies used different experimental approaches in order to detect AT2-receptor-related effects such as AT2-receptor deficiency or overexpression, treatment with an AT1-receptor blocker leading to indirect stimulation of ...
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