Search Results
Results 151 - 200 of 6440
1 2 3 4 5 6 7 8 9 10 >
Kamal Fadia A FA The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
elevated sympathetic nervous system activity is a salient characteristic of heart failure (HF) progression. It causes pathologic desensitization of β -adrenergic receptors (β -AR), facilitated predominantly through Gβ γ-mediated signaling. The adrenal glands are key contributors to the chronically elevated plasma catecholamine levels observed in HF, where adrenal α2-AR feedback ...
Haensch Carl-Albrecht CA Department of Neurology, Maria Hilf Kliniken Mönchengladbach, University of Witten/Herdecke, - - 2014
Introduction: Postural tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterized by excessive tachycardia of unknown etiology. Our objective was to evaluate the correlation between C-fiber involvement shown by skin biopsy and adrenergic cardiac MIBG-uptake in POTS patients. Methods: Skin biopsies of 84 patients with POTS were examined by ...
Biteker Murat - - 2014
Peripartum cardiomyopathy (PPCM) is a form of idiopathic dilated cardiomyopathy affecting women in late pregnancy or early puerperium. Although initially described in the late 1800s, it has only recently been recognized as a distinct cardiac condition. The reported incidence and prognosis varies according to geography. The clinical course varies between ...
Stoupel Eliiyahu E Division of Cardiology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Many publications in recent decades have reported a temporal link between medical events and environmental physical activity. The aim of this study was to analyze the time of occurrence of electrical heart storms against levels of cosmological parameters. The sample included 82 patients (71 male) with ischemic cardiomyopathy treated with ...
Rath Claus - - 2014
Pacemaker lead malpositioning with subsequent cardiac tamponade is a rare, but serious adverse event. We herein report a case of pacemaker lead malpositioning in a 76-year old female caucasian patient. The lead was malpositioned into the roof of the left atrium after perforation of the superior vena cava, resulting in ...
Liu Shanxin S Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, - - 2014
Atrial fibrillation (AF) is the most common arrhythmic complication after cardiac surgery. Several studies have compared the efficacy of landiolol and placebo or other agents in preventing new-onset AF in patients after cardiac surgery. In this study, we conducted a meta-analysis to determine whether landiolol is effective in preventing new-onset ...
Kim Tae Kyum TK Department of Biomedical Science, Hallym University, Chuncheon, South Korea; BodiTech Med, Inc, Chuncheon, South - - 2014
Myoglobin, creatine kinase-MB isoenzyme (CK-MB), and cardiac troponin I (cTnI) are cardiac biomarkers that are widely used to assist in the early and late diagnoses of acute myocardial infarction (AMI). Here, we present a clinically applicable fluorescence (FL) immunoassay for cardiac biomarkers. Whole blood was mixed with FL-labeled detector Ab ...
Domsik Péter P 2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, - - 2014
Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric ...
Furtado Milena B MB Australian Regenerative Medicine Institute, Monash - - 2014
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment but appreciation of their contribution has suffered from incomplete characterization and lack of cell-specific markers. To generate an unbiased comparative gene expression profile of the cardiac fibroblast pool, identify and characterize the role of key ...
Claveau David D Department of Emergency Medicine, Centre de santé et de services sociaux de Trois-Rivières, Centre hospitalier affilié universitaire régional, Trois-Rivières, Quebec, - - 2014
Cardiac tamponade from necrotizing descending mediastinitis is a rare but life-threatening complication of cervicofacial infections. A 49-year-old woman presented in shock with pleuretic chest pain at a small community clinic. She was transferred to our emergency department where cardiac tamponade was diagnosed and drained. Her initial complete blood count and ...
Petri Helle H Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: - - 2014
Patients with myotonic dystrophy type 1 (DM1) have a three-fold higher risk of sudden cardiac death (SCD) than age-matched healthy controls. Despite numerous attempts to define the cardiac phenotype and natural history, existing literature suffers from low power, selection-bias and lack of controls. Thus, the optimal strategy for assessing cardiac ...
Sohns J M JM Institute for Diagnostic and Interventional Radiology, University Medical Center of Georg-August-University, - - 2014
Purpose: The aim of this study was to assess the incidence of cardiac and significant extra-cardiac findings in clinical computed tomography of the heart in patients with atrial fibrillation before pulmonary vein isolation (PVI). Materials and Methods: 224 patients (64 ± 10 years; male 63 %) with atrial fibrillation were examined by cardiac ...
Grandmougin D D Department of Cardiovascular Surgery and Transplantations. ILCV. Louis Mathieu. CHU-Nancy, Vandoeuvrelès, Nancy, France - - - 2014
Aim: Despite controversies, OPCAB surgery has become a routine procedure. Obvious advantages have been demonstrated in highrisk patients. However, OPCAB surgery has limitations in specific highrisk situations with hazards of operative deleterious events. We describe an innovative procedure of Self-Myocardial Retroperfusion (SMR) with an Aortic-Coronary Sinus Shunt (ACSS). We prospectively ...
Masci Pier Giorgio PG 1Fondazione CNR/Regione Toscana 'G. Monasterio', Pisa, - - 2014
-We conducted a prospective longitudinal study to investigate the yet unknown clinical significance of myocardial fibrosis in non-ischemic cardiomyopathy(NICM) patients without history of congestive heart failure(CHF). -At 3 tertiary referral Centers, 228 NICM patients without history of CHF were studied with cardiovascular magnetic resonance(CMR) for late gadolinium enhancement(LGE) detection and ...
Nabati Maryam M Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, - - 2014
Double-outlet right ventricle (DORV), a clinically important congenital heart disease, occurs in 1-3% of persons with congenital heart disease. It may occur as an isolated cardiac defect, together with other cardiac lesions, or in association with extracardiac anomalies. Other rare cardiac anomalies include an anomalous muscle bundle (AMB) in the ...
Hatem Stéphane N SN Institute of Cardiometabolism and Nutrition, Paris, - - 2014
Atrial fibrillation (AF) is the most frequent cardiac arrhythmia in clinical practice. AF is often associated with profound functional and structural alterations of the atrial myocardium that compose its substrate. Recently, a relationship between the thickness of epicardial adipose tissue (EAT) and the incidence and severity of AF has been ...
Radunski U K UK Cardiology, University Heart Center, - - 2014
Purpose: Percutaneous mitral valve repair with the MitraClip device (Abbott Vascular, Redwood City, California, USA) is a novel therapeutic option in patients with mitral regurgitation. This study evaluated the feasibility of cardiac volume measurements by cardiovascular magnetic resonance imaging (CMR) to assess reverse myocardial remodeling in patients after MitraClip implantation. ...
Jordan Jennifer H JH From the Departments of *Internal Medicine (Section of Cardiology), †Biostatistical Sciences, ‡Biomedical Engineering, and §Radiology, Wake Forest School of Medicine, Winston-Salem, - - 2014
The objective of this study was to assess the frequency and prognostic utility of small, short-duration left ventricular myocardial perfusion defects during dobutamine cardiovascular magnetic resonance (DCMR) stress imaging. We performed first-pass contrast-enhanced DCMR at peak stress in 331 consecutively recruited individuals (aged 68 ± 8 years, 50% men) at ...
Fantinelli Juliana C JC Established Investigator of CONICET, Centro de Investigaciones Cardiovasculares, Universidad Nacional de La Plata, La Plata, Buenos Aires, - - 2014
Although the participation of the electrogenic sodium/bicarbonate cotransporter (NBCe1) in the recovery from an intracellular acid load is recognized, its role in ischemia-reperfusion is still unclear. Our objective was to assess the role of NBCe1 in reperfusion injury. We use selective functional antibodies against extracellular loop 3 (a-L3) and loop ...
Lim Soyeon S Severance Integrative Research Institute for Cerebral & Cardiovascular Disease, Yonsei University Health System, 50 Yonsei-ro, Seodamun-gu, Seoul 120-752, Republic of - - 2014
Myocardial Ca(2+) overload induced by ischemia/reperfusion (I/R) is a major element of myocardial dysfunction in heart failure. Phospholipase C (PLC) plays important roles in the regulation of the phosphoinositol pathway and Ca(2+) homeostasis in various types of cells. Here, we investigated the protective role of PLCδ1 against myocardial ischemia/reperfusion injury ...
Graham Ph P Cancer Care Centre, St George Hospital, University of New South Wales, Sydney, New South Wales, - - 2014
The purpose of this study was to evaluate the cardiac dosimetry delivered before and after routine 3D CT whole-breast radiotherapy planning, including cardiac contouring and the relevance of a 15-mm maximum myocardial depth (MMD) planning tolerance threshold. The PULp FICTion study permitted cardiac dosimetry comparisons for 140 patients (70 in ...
Cuypers Judith A A E JA Department of Cardiology, Erasmus MC, PO Box 2040, Rotterdam 3015 CE, The - - 2014
To describe long-term survival, clinical outcome and ventricular systolic function in a longitudinally followed cohort of patients after Mustard repair for transposition of the great arteries (TGA). There is serious concern about the long-term outcome after Mustard repair. This longitudinal single-centre study consisted of 91 consecutive patients, who underwent Mustard ...
Rassaf Tienush T Cardiology, Pulmonology, Angiology, University Hospital - - 2014
Remote ischemic preconditioning (rIPC) with short episodes of ischemia and reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the crosstalk between the remote site and the heart remain unclear in detail. To elucidate the ...
Narayanan Kumar K Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Left ventricular hypertrophy (LVH) is associated with increased risk of sudden cardiac arrest (SCA); whether LVH diagnosed by 12-lead ECG versus echocardiogram conveys identical or distinct risk information has not been previously evaluated. To compare the association between ECG versus echocardiographic LVH and SCA in the community. In a large, ...
Adelstein Evan E University of Pittsburgh Heart and Vascular Institute, Pittsburgh, Pennsylvania. Electronic address: - - 2014
Pacemaker-dependent patients with left ventricular (LV) dysfunction benefit from upgrade to cardiac resynchronization therapy (CRT). Those at low risk for ventricular tachyarrhythmias may benefit similarly from a CRT-defibrillator or CRT-pacemaker. To determine if coronary artery disease (CAD), because of associated scar that supports reentry, predicts higher risk of appropriate shocks ...
Auricchio Angelo A Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, - - 2014
Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypothesized that the Physiological Diagnostic ...
Tarone Guido G Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Torino, - - 2014
The failing heart is characterized by complex tissue remodelling involving increased cardiomyocyte death, and impairment of sarcomere function, metabolic activity, endothelial and vascular function, together with increased inflammation and interstitial fibrosis. For years, therapeutic approaches for heart failure (HF) relied on vasodilators and diuretics which relieve cardiac workload and HF ...
Sallam Karim K Stanford Cardiovascular - - 2014
Advances in the understanding and treatment of cardiac disorders have been thwarted by the inability to study beating human cardiac cells in vitro. Induced pluripotent stem cells (iPSCs) bypass this hurdle by enabling the creation of patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). These cells provide a unique platform to study cardiac diseases ...
Zavadzkas Juozas A JA Medical University of South - - 2014
Myocardial infarction (MI) causes an imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) and is associated with adverse LV remodeling. A uniform reduction in TIMP-4 post-MI has been observed. Examine post-MI remodeling with cardiac restricted overexpression of TIMP-4, either through a transgenic or viral delivery approach. MI ...
Magrì Damiano D Department of Clinical and Molecular Medicine, Sapienza - - 2014
Background: Growing evidence suggests that late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) is an additive marker of disease severity, and possibly of arrhythmic risk, in hypertrophic cardiomyopathy (HCM). We investigated the possible relationship between LGE and markers of myocardial repolarization dispersion in HCM. Methods and Results: Eighty-five HCM outpatients underwent ...
Zhao Shu-Li - - 2014
Elevated midkine (MK) expression may contribute to ventricular remodeling and ameliorate cardiac dysfunction after myocardial infarction (MI). Ex vivo modification of signaling mechanisms in mesenchymal stem cells (MSCs) with MK overexpression may improve the efficacy of cell-based therapy. This study sought to assess the safety and efficacy of MSCs with ...
Codreanu I I Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, - - 2014
Objective: Obtaining new details of radial motion of left ventricular (LV) segments using velocity-encoding cardiac MRI. Methods: Cardiac MR examinations were performed on 14 healthy volunteers aged between 19 and 26 years. Cine images for navigator-gated phase contrast velocity mapping were acquired using a black blood segmented κ-space spoiled gradient ...
Sobrino Ayax A Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, - - 2014
To evaluate intra-procedural imaging with transesophageal echocardiography and angiography during left atrial appendage occlusion using the Amplatzer™ Cardiac Plug with regard to sizing and final device shape. Left atrial appendage ostium dimensions and diameter at a depth of 10mm from the ostium were measured by transesophageal echocardiography (0-180°) and angiography ...
Zellars Richard R Johns Hopkins Medical Institution, Baltimore, Maryland. Electronic address: - - 2014
Cardiac muscle perfusion, as determined by single-photon emission computed tomography (SPECT), decreases after breast and/or chest wall (BCW) irradiation. The active breathing coordinator (ABC) enables radiation delivery when the BCW is farther from the heart, thereby decreasing cardiac exposure. We hypothesized that ABC would prevent radiation-induced cardiac toxicity and conducted ...
Tsutsumi Yasuo M YM Department of Anesthesiology, University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan, - - 2014
Pharmacological preconditioning, including that with geranylgeranylacetone (GGA) and volatile anesthetics, has been shown to confer cardiac protection from ischemia/reperfusion injury although the mechanisms for this protection are poorly understood. Caveolins, integral membrane proteins that act as scaffolding proteins in caveolar membranes, localize molecules involved in cardiac protection. We have tested ...
Cao L L Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270, Dong An Road, 200032 Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, - - 2014
To analyse the risk factors associated with acute cardiotoxicity in HER2-positive breast cancer patients receiving concurrent trastuzumab and radiotherapy. Medical records of 45 breast cancer patients treated between 02/2009 and 02/2011 by concurrent trastuzumab and radiotherapy were collected. Radiation was delivered to the conserved breast or chest wall with or ...
Ruwald Anne Christine AC Department of Cardiology, Gentofte University Hospital, Copenhagen, - - 2014
Previous studies have shown substantially increased risk of cardiac arrhythmias and sudden cardiac death in post-myocardial infarction (MI) patients. However it remains difficult to identify the patients who are at highest risk of arrhythmias in the post-MI setting. The purpose of this study was to investigate if CHADS2 score (congestive ...
Shen Mark J MJ From Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, - - 2014
The autonomic nervous system plays an important role in the modulation of cardiac electrophysiology and arrhythmogenesis. Decades of research has contributed to a better understanding of the anatomy and physiology of cardiac autonomic nervous system and provided evidence supporting the relationship of autonomic tone to clinically significant arrhythmias. The mechanisms ...
Spiliopoulos Sotirios S Department of Surgical Therapy of End-stage Heart Failure and Mechanical Circulatory Support, Heart and Vascular Center Duisburg, Duisburg, - - 2014
The SynCardia total artificial heart is currently used as a bridge to transplantation therapy in cases of irreversible, acute or chronic, biventricular heart failure. We describe the implementation of this technology in the context of destination therapy in a patient with an end-stage heart failure on grounds of primary amyloidosis.
Sade Leyla Elif LE University of Pittsburgh, Pittsburgh, - - 2014
Response to cardiac resynchronization therapy is variable. The aim of this study was to test the hypothesis that left ventricular (LV) lead position in proximity to myocardial scar is associated with less favorable outcomes. A total of 149 patients were included in this substudy of the Speckle Tracking Assisted Resynchronization ...
Qin Fuzhong F Boston University School of - - 2014
Oxidative stress in the myocardium plays an important role in the pathophysiology of hemodynamic overload. The mechanism by which reactive oxygen species (ROS) in the cardiac myocyte mediate myocardial failure in hemodynamic overload is not known. Accordingly, our goals were to test whether myocyte-specific overexpression of peroxisomal catalase (pCAT) that ...
Welch Terrence D TD 1Section of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, and Geisel School of Medicine at Dartmouth, Hanover, - - 2014
-Constrictive pericarditis is a potentially reversible cause of heart failure that may be difficult to differentiate from restrictive myocardial disease and severe tricuspid regurgitation. Echocardiography provides an important opportunity to evaluate for constrictive pericarditis, and definite diagnostic criteria are needed. -Patients with surgically-confirmed constrictive pericarditis (n=130) at Mayo Clinic (2008-2010) ...
Rinaldi C Aldo CA Cardiac Department, St Thomas' Hospital, London, SE1 7EH, UK, - - 2014
A quadripolar left ventricular (LV) pacing can deliver multipoint pacing (MPP). It is unknown if this confers improved cardiac function compared to conventional cardiac resynchronization therapy (CRT). We aimed to characterize changes in acute cardiac contractility and hemodynamics with multisite left ventricular "multipoint" pacing (MPP) in a prospective multicenter study ...
Peters Tim T Experimental Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The - - 2014
Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts ...
Tanaka Koji K Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, - - 2014
Atrial fibrillation impairs left atrial appendage function and the thrombus formation in the left atrial appendage is a major cause of cardioembolic stroke. To evaluate the association between the volume of the left atrial appendage measured by real-time three-dimensional transesophageal echocardiography and presence of paroxysmal atrial fibrillation in patients with ...
Zafrir Nili N Nuclear Cardiology Unit, Rabin Medical Center, Beilinson Campus, 49100, Petah Tikva, Israel, - - 2014
Left ventricular (LV) dyssynchrony by phase analysis has been studied by myocardial perfusion imaging (MPI)-gated SPECT in patients with LV dysfunction in various clinical settings. We aimed to investigate the routine use of phase analysis with gated SPECT for predicting cardiac outcome. Patients referred to a tertiary medical center in ...
Li Qiaoling Q Department of Cardiology, Drum Tower Clinical Medical Hospital, Nanjing Medical University, Nanjing, - - 2014
MicroRNAs are involved in the regulation of various cellular processes, including cell apoptosis and autophagy. Expression of microRNA-99a (miR-99a) is reduced in apoptotic neonatal mice ventricular myocytes (NMVMs) subjected to hypoxia. We hypothesize that miR-99a might restore cardiac function after myocardial infarction (MI) by up-regulation of myocyte autophagy and apoptosis. ...
Seitz Stefanie S Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, - - 2014
A girl received an ABO incompatible heart transplantation (ABOiHTx) at the age of 3.5 years for failed univentricular palliation with protein losing enteropathy (PLE). She was born with a hypoplastic left heart syndrome and underwent multi stage palliation to a Fontan circulation at 2 ½ years of age. After the ...
Hestenes Siv M SM 1Intervention Centre, Oslo University Hospital, Oslo, Norway. 2Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway. 3Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 4KG Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway. 5Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 6Department of Emergency Medicine, Nordland Hospital, Bodø, Norway. 7University of Nordland, Bodø, Norway. 8Faculty of Health Sciences, University of Tromsø, Tromsø, - - 2014
Cardiovascular failure is an important feature of severe sepsis and mortality in sepsis. The aim of our study was to explore myocardial dysfunction in severe sepsis. Prospective experimental study. Operating room at Intervention Centre, Oslo University Hospital. Eight Norwegian Landrace pigs. The pigs were anesthetized, a medial sternotomy performed and ...
Verkuil Bart B Institute of Psychology, Leiden University. Electronic address: - - 2014
Excessive cardiac responses to stressful events are a risk factor for morbidity and mortality. Adverse cardiac responses are usually attributed to conscious negative stress and emotions. Yet, cardiac responses might also be affected by emotions that are not consciously reported. Here we tested this hypothesis. Sixty participants were randomly allocated ...
1 2 3 4 5 6 7 8 9 10 >