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Pianca N N Department of Biomedical Sciences, Padova, - - 2014
Cardiac Sympathetic Neurons (cSNs) densely innervate the myocardium and operate physiologically both as short term enhancers of cardiac function, and as constitutive regulator of cardiomyocyte (CM) size, by controlling proteolysis through the β2-AR/FOXO3/MuRF-1 dependent signaling axis (1). The density of cSNs decreases progressively from the epi- to the endocardium. We ...
Perera R K RK Heart Research Center Gottingen, Georg-August University, Department of Cardiology and Pneumology, Gottingen, - - 2014
Atrial natriuretic peptide (ANP) is a well-known vasodilatory factor and crucial hormone for adaptation to increased blood pressure. ANP plasma levels rise upon elevated cardiac afterload during aortic stenosis and, via guanylyl cyclase A, stimulate cardiomyocyte cGMP levels. Cardiac cGMP is considered as a protective second messenger which counteracts detrimental ...
Jayaram R R University of Oxford, Cardiovascular Medicine, Oxford, United - - 2014
The mechanisms responsible for myocardial stunning after cardiac surgery are only partially understood, although ischemia - reperfusion (IR) injury associated with cardio pulmonary bypass (CPB) may play an important role. Reactive oxygen species and nitric oxide have been implicated in both myocardial injury and cardio protection suggesting that identification of ...
Rutkovskiy A A University of Oslo, Institute of Basic Medical Sciences, dept. Physiology, Oslo, - - 2014
Bone morphogenetic protein-2 (BMP2) is known for its wide role in embryonic heart development, encompassing the differentiation of cardiomyocytes, vascularization, valvulogenesis and connective tissue formation. However, BMP2 function in the adult heart is unknown. Recent work indicates that other BMP family members may be involved in myocardial remodeling. We hypothesized ...
Gomez Salinero J M JM National Centre for Cardiovascular Research (CNIC), Madrid, - - 2014
Embryonic stem cells (ESCs) have the ability to proliferate indefinitely in culture, and to differentiate into all embryonic lineages. Although the transcriptional program that coordinates pluripotency has been progressively unveiled during the past few years, the signalling pathways that regulate early differentiation events are not completely understood. We have recently ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The proinflammatory cytokines may mediate myocardial dysfunction associated with myocardial infarction, severe congestive heart failure, and sepsis. A growing body of evidence suggests that inflammatory mediators could play a crucial role in ischemia-reperfusion injury. Furthermore, ischemia-reperfusion not only results in the local transcriptional and translational upregulation of cytokines but also ...
Jacques D D University of sherbrooke, anatomy and cell biology, Sherbrooke, - - 2014
Cardiomyopathy in general is defined as a disease of the heart muscle. The purpose of this study is to test the hypothesis that sodium-hydrogen exchanger (NHE1) abnormality is a common cause of cardiac and vascular failures in hereditary cardiomyopathy of the hamster. We verified whether heart failure is accompanied by ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The importance of apoptosis in cell death following ischemia and reperfusion has been demonstrated in vivo rodent models,. Thyroid hormone can have positive effects on the cardiovascular system but its therapeutic potential is limited secondary to its adverse effects. DITPA has been shown to reduce pathologic remodeling and improve cardiac ...
Syeda F F University of Birmingham, Cardiovascular Sciences, Clinical and Experimental Medicine, Birmingham, United - - 2014
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death in young athletes. Loss-of-function mutations of desmosomal proteins including plakoglobin are linked with ARVC and ventricular arrhythmias in trained mice. Intensive endurance training increases atrial arrhythmias in rats. We tested endurance-trained heterozygous plakoglobin deficient (Plako+/-) mice for ...
Baysa A A University of Oslo, Institute of Basic Medical Sciences (IMB), Department of Physiology, Oslo, - - 2014
Heart failure is a growing problem worldwide. Cardiac remodeling, which features aseptic inflammation, metalloproteinase (MMP) activation and induction of matricellular proteins, contributes to heart failure progression after myocardial infarction (MI). The ShcA gene encodes three isoforms: p46-, p52- and p66ShcA, which are crucial for embryonic development of the heart. The ...
Lucas A A Inserm-UPS U1048, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse, - - 2014
Postinfarction remodeling is accompanied and influenced by perturbations in oxidative stress status and MAPK signaling. The Growth arrest and DNA-damage-inducible 45 (Gadd45) proteins are small acidic proteins involved in modulation of MAPK activities. Despite its relationship with p38 MAPK and intense interest in the cancer field, little is known about ...
Skyschally A A University of Essen Medical School, Institute for Pathophysiology, Essen, - - 2014
Remote ischemic preconditioning (RIPC), i.e. brief episodes of ischemia/reperfusion in a remote organ, protects the heart against infarction after myocardial ischemia/reperfusion. However, the transfer of protection from the remote ischemic/reperfused organ to the heart is still not understood. Here we address the transfer of a blood-borne cardioprotective factor from a ...
Van Hout G P J GP University Medical Center Utrecht, Division Heart and Lungs, Experimental Cardiology, Utrecht, - - 2014
Revascularization after myocardial infarction (MI) induces a strong inflammatory response resulting in an increase of circulating neutrophils. Neutrophil quantities have found to be a good predictor for future adverse events. In this study, we hypothesized that the extent of morphological changes in circulating neutrophils also reflects the myocardial damage after ...
Horckmans M M Ludwig-Maximilians University, Institute for Cardiovascular Prevention (IPEK), Munich, - - 2014
Neutrophils contribute to tissue damage after acute myocardial ischemia and reperfusion, but their role in infarct healing is less well understood. Because neutrophil-derived granule proteins mediate classical monocyte recruitment in acute inflammation, we hypothesized that neutrophil depletion during the acute inflammatory phase will improve infarct healing by reducing the proinflammatory ...
Van Lier Mgjtb M Academic Medical Center of Amsterdam, Department of Biomedical Engineering & Physics, Amsterdam, - - 2014
Myocardial tissue ischemia may be mitigated by a well-developed coronary collateral circulation. Only few detailed 3D data are available of the entire human coronary arterial tree. Here, high-resolution reconstructions of the coronary vasculature of two human hearts were quantitatively analyzed. Two hearts became available through autopsy: heart #1 (64 years, ...
Gonzalez Tendero A A Hospital Clinic, IDIBAPS, Department of Maternal-Fetal Medicine, Barcelona, - - 2014
Intrauterine growth restriction (IUGR) is associated with prenatal changes in cardiac shape and function that persist in childhood and may be associated to an increased cardiovascular mortality in adulthood. Ultrasound and MRI provide information at organ level, but their resolution is too low. Microscopy provides detail at cellular and subcellular ...
Fernandez-Jimenez R R National Centre for Cardiovascular Research (CNIC), Epidemiology, Atherothrombosis and Imaging Department, Madrid, - - 2014
Myocardial infarct size estimation using biomarkers -creatine kinase (CK) and troponin (cTn) - is commonly used as the primary endpoint in many experimental studies and clinical trials. We recently described for the first time in a retrospective study that peak of cTnI could overestimate infarct size in presence of left ...
Avolio E E University of Udine, Department of Medical and Biological Sciences, Udine, - - 2014
Cellular senescence associated with ageing and disease hampers the functional properties of human c-Kit+ Cardiac Stem Cells (CSC) in vitro. Aim of the study was to identify molecular mechanisms associated with CSC senescence and to pharmacologically modulate this latter, at the aim to improve the therapeutic potential of CSC in ...
Iaccarino D D University of Padova, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Padua, - - 2014
The gene Coiled Coil Domain Containing 80 (Ccdc80) is highly expressed in the hearts of vertebrates and its role is well defined in tumor suppression, glucose homeostasis and adipocyte differentiation. Our aims are to define its functional role during embryonic development and in cardiomyopathies. We used 3 different models: 1. ...
Kulaveerasingam D D King's College London, Randall Division of Cell and Molecular Biophysics, London, United - - 2014
Hypertrophy and hyperplasia play key roles in the growth of heart muscle. Following formation of the zebrafish heart tube at one day post fertilisation (dpf), it is currently thought that cell addition at the poles of the heart, with little proliferation of cardiomyocytes, results in growth until 2 dpf. From ...
Perez-Pomares J M JM University of Málaga, Málaga, - - 2014
Myocardial infarction is a prevalent cardiovascular disease. Mechanisms of repair in the post-infarcted heart include a progressive fibrosis that severely affects cardiac performance, eventually leading to cardiac failure. Cardiac fibrosis in the context of ventricular remodeling after infarction depends on fibroblasts of the cardiac interstitium (cardiac fibroblasts), a heterogeneous population ...
Constantin M M Electrophysiology and Heart modeling Institute (IHU-Liryc), Inserm U1045, University of Bordeaux, Pessac-Bordeaux, - - 2014
Cardiac gap junctions display distinct electrical properties in the different tissues that ensure the coordinated propagation of the action potential. They are clusters of intercellular gap junction channels (GJC) composed of connexins (Cxs) Cx40, Cx43, Cx45 and Cx30.2, which exhibit specific pattern of expression in the healthy heart. Importantly, in ...
Miskolczi G G University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have evidence that rapid cardiac pacing preserves gap junction (GJ) function by preventing the structural alterations that occur during ischaemia, 24h later; a mechanism which play a role the pacing-induced delayed protection against arrhythmias. Purpose: The present study has now examined whether closing of GJs prior to ischaemia with ...
Revnic C R CR C.C.Iliescu Cardiology Dpt, Bucharest, - - 2014
Heart muscle is largely dependent on uninterrupted blood flow, which guarantees delivery of substrates and washout of harmful products of metabolism. During aging, a lot of degenerative changes occur at the levels of all organs and heart is not an exception. Ischemia is a frequent phenomenon associated with aging and ...
Gonczi M M University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have previously reported that rapid cardiac pacing preserves the function of gap junction channels (GJ) during ischaemia and reperfusion, 24h later. This result has suggested a role for these channels in the delayed antiarrhythmic protection. The present study was designed to provide further evidence to this relationship using carbenoxolone ...
Louwe Mc M Leiden University Medical Center, Dept. Endocrinology and Metabolic Diseases, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, - - 2014
Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signalling domain that competitively inhibits TLR4-signalling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signalling, would lead ...
Baranyai T T Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, - - 2014
Remote ischemic preconditioning (RIPC) of the heart (i.e. brief ischemia/reperfusion cycles, subjected to a remote organ or a remote area, reduce the consecutive damage of a sustained cardiac ischemia. Although, its mechanism has been investigated thoroughly, exact interorgan transfer mechanisms of cardioprotection by RIPC are required to be further investigated. ...
Ciccarelli M M University of Salerno, Salerno, - - 2014
Heart Failure (HF) is a complex disease characterized by progressive cardiac dilation and loss of ATP content needed to accomplish myocardial contractile function. GRK2 is a serine/threonine kinase that phosphorylates and binds receptors coupled to G proteins, such as β-adrenergic receptors (βAR) and it is involved in the pathophysiology of ...
Radovits T T Semmelweis University, Heart and Vascular Center, Budapest, - - 2014
Pathological cardiac hypertrophy is observed in pressure overload of the left ventricle. Elevated intracellular cGMP-levels have been reported to prevent the development of pathological myocardial hypertrophy. We investigated the effects of chronic activation of the cGMP producing enzyme, soluble guanylate cyclase (sGC) by cinaciguat in a rat model of pressure ...
Perea Gil I I Health Research Institute Germans Trias, Badalona, - - 2014
Cardiac tissue engineering emerges as a promising alternative to current therapies addressed to myocardial infarction. In this context, we aimed to obtain and characterize myocardial bioprosthesis based on a decellularized matrix capable of being engrafted in damaged myocardium. Myocardial blocks (3x3 cm), differentiating epicardial, mesocardial and endocardial regions, were obtained ...
Singh Kuljit K Department of Cardiology, Queen Elizabeth Hospital, Adelaide, Australia. Electronic address: - - 2014
Takotsubo cardiomyopathy (TTC) is often associated with hypotension and shock. However, development of hypotension/shock in TTC is not closely related to extent of left ventricular (LV) hypokinesis. We sought to determine whether additional right ventricular (RV) involvement in TTC might contribute to hypotension and shock development and thus to prolonged ...
Cervellin Gianfranco G Emergency Department, Academic Hospital of Parma, Parma, - - 2014
The history of myocardial infarction (MI) diagnostics has gone through a continuous evolution over the past century, when several new discoveries have contributed to remarkably increase the number of patients appropriately diagnosed with this condition. The tale "of MIs and Men" displays rather a long history, since atherosclerosis was found ...
Lima-Leopoldo Ana Paula AP Federal University of Espirito Santo - - 2014
Few studies have evaluated the relationship between the duration of obesity, cardiac function and the proteins involved in myocardial calcium (Ca(2+)) handling. We hypothesized that long-term obesity promotes cardiac dysfunction due to a reduction of expression and/or phosphorylation of myocardial Ca(2+)-handling proteins. Thirty-day-old male Wistar rats were distributed into two ...
Lip Gregory Yh GY City Hospital, Birmingham, United Kingdom & Aalborg University, Aalborg, Denmark - - 2014
Advances in pharmacological and devices therapy have greatly improved prognosis in patients with systolic heart failure. Despite this congestive heart failure still bears a very grim prognosis, particularly in patients with more advances stages of the disease that are so frequently seen on hospital wards. Which pathogenic pathways may need ...
Ferrari Roberto R Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy - - 2014
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explore new therapeutic avenues. The Notch pathway is an evolutionary conserved fundamental pathway that ...
Peng Ying Y UW-Madison, United - - 2014
Heart failure (HF) is a leading cause of morbidity and mortality worldwide and is most often precipitated by myocardial infarction (MI). However, the molecular changes driving cardiac dysfunction immediately after MI remain poorly understood. Myofilament proteins, responsible for cardiac contraction and relaxation, play critical roles in signal reception and transduction ...
Stallone Fabio F Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland Department of Cardiology, University Hospital Basel, Basel, - - 2014
Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition to cardiac troponin in the early rule-out of acute myocardial infarction (AMI). Prevalence, characteristics and outcome of acute chest pain patients with causes other than AMI and elevated copeptin are poorly understood. A total of 984 ...
Gorjup Vojka V Vojka Gorjup, Marko Noc, Peter Radsel, Department of Intensive Internal Medicine, University Medical Center Ljubljana, 1000 Ljubljana, - - 2014
Coronary artery disease is the most frequent cause of sudden cardiac death. There is general consensus that immediate coronary angiography with percutaneous coronary intervention (PCI) should be performed in all conscious and unconscious patients with ST-elevation myocardial infarction in post-resuscitation electrocardiogram. In these patients acute coronary thrombotic lesion ("ACS" lesion) ...
Malfitano Christiane C Christiane Malfitano, Laboratório de Fisiologia Translacional, UNINOVE, 01504001 São Paulo, - - 2014
While clinical data have suggested that the diabetic heart is more susceptible to ischemic heart disease (IHD), animal data have so far pointed to a lower probability of IHD. Thus, the aim of this present review is to look at these conflicting results and discuss the protective mechanisms that conditioned ...
Zhao Zhi-Gang ZG Intensive Care Unit, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, - - 2014
Embelin has been used to treat fever and inflammatory diseases for thousands of years. Although reports indicate that embelin has antiinflammatory effects, its effects on myocardial injury following cardiac arrest (CA) have not been previously explored. In this study, we aim to investigate the protective effects of embelin on myocardial ...
Karmali Kunal N KN Departments of Preventive Medicine and Medicine (Cardiology), Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, USA, - - 2014
Cardiac rehabilitation is an important component of recovery from coronary events but uptake and adherence to such programs are below recommended levels. In 2010, our Cochrane review identified some evidence that interventions to increase uptake of cardiac rehabilitation can be effective but there was insufficient evidence to provide recommendations on ...
Prunet Bertrand - - 2014
Although aneurysmal subarachnoid hemorrhage (SAH) is often complicated by myocardial injury, whether this neurogenic cardiomyopathy is associated with the modification of cardiac metabolism is unknown. This study sought to explore, by positron emission tomography/computed tomography, the presence of altered cardiac glucose metabolism after SAH. During a 16-month period, 30 SAH ...
Boopathy Archana V AV Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown promising outcomes. Notch1 signaling plays a critical role in cardiac development and in the survival, cardiogenic lineage commitment, and differentiation of cardiac stem/progenitor cells. In this study, we functionalized ...
de Waha Suzanne - - 2014
This study aimed to evaluate the incremental prognostic value of infarct size, microvascular obstruction (MO), myocardial salvage index (MSI), and left ventricular ejection fraction (LV-EFCMR) assessed by cardiac magnetic resonance imaging (CMR) in comparison to traditional outcome markers in patients with ST-elevation myocardial infarction (STEMI) reperfused by primary percutaneous intervention ...
Ganapathi Asvin M AM Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, - - 2014
Patients with thoracic aortic disease undergoing thoracic endovascular aortic repair (TEVAR) often have concomitant coronary artery disease and are at risk for perioperative adverse cardiac events. Despite this risk, the need for and extent of preoperative cardiac workup before TEVAR remain undefined. This study seeks to assess the adequacy of a ...
Borlaug Barry A BA The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, - - 2014
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials ...
Hatipoglu Suzan S Department of Cardiology, Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey, - - 2014
In the absence of mitral valve disease left atrial (LA) volume is a marker of diastolic dysfunction and its severity. This study investigated the relationship between left ventricular (LV) end diastolic pressure (LVEDP) and LA volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (RT3DE), in a ...
Myers J A JA Triangle Veterinary Referral Hospital, Raleigh, - - 2014
Information regarding cardiac changes in domestic cats with acromegaly is limited. The objective of this study was to describe the echocardiographic findings in cats with acromegaly. Eighteen cats diagnosed with acromegaly at Colorado State University between 2008 and 2012. Of these 18 cats, 11 had echocardiography performed. A retrospective review ...
Umoh Nsini A NA Department of Physiology & Biophysics, College of Medicine, Howard University, Washington, District of - - 2014
Clinical manifestations of alcohol abuse on the cardiac muscle include defective contractility with the development of heart failure. Interestingly, low alcohol consumption has been associated with reduced risk of cardiovascular disease. Although several hypotheses have been postulated for alcoholic cardiomyopathy and for the low-dose beneficial cardiovascular effects, the precise mechanisms ...
Zhang Yixuan Y UCLA, United - - 2014
Oxidative stress has been implicated in cardiac arrhythmia, although a causal relationship remains undefined. We have recently demonstrated a marked upregulation of NADPH oxidase isoform 4 (NOX4) in patients with atrial fibrillation (AF), which is accompanied by overproduction of reactive oxygen species (ROS). In the present study we investigated impact ...
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