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Choudhury Partha Prateem PP Department of Cardiology, GB Pant Hospital, New Delhi, - - 2014
A 58 year old male, known case of type 2 diabetes and hypertension, had undergone implantation of a dual chamber pacemaker(DDDR) in 2007 for complaints of recurrent syncope and trifascicular block with a normal ejection fraction andnormal coronaries. His post implantation parameters were normal at that time.He now presented to ...
Chen Wei-Kung WK Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40440, Taiwan, Republic of - - 2014
Obesity is often associated with the development of cardiac hypertrophy but the hypertrophyrelated pathways in obesity remain unknown. The purpose of this study was to evaluate cardiac hypertrophy-related markers, atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), tumor necrosis factor-alpha (TNFα) and hypertrophy-related pathways, interleukin (IL)-6-STAT3, IL-6-MEK5-ERK5 and calcineurin-nuclear factor ...
Wang Han-Jun HJ From the Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, - - 2014
The enhanced cardiac sympathetic afferent reflex (CSAR) contributes to the exaggerated sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively related to mortality in patients with CHF. However, the potential beneficial effects of chronic CSAR deletion on cardiac and autonomic function in CHF have not been previously explored. Here, ...
Michlik Katarzyna M - - 2014
Quadricuspid aortic valve (QAV) and ventricular septal defect (VSD) are congenital heart defects and have been described in both human and veterinary medical literature. A 5-year-old half-bred bay stallion was referred for surgical castration. Cardiac murmurs were heard on the presurgical clinical examination and the cardiac examination revealed subcutaneous oedema, ...
Löfsjögård Johan - - 2014
Abstract Objectives: Alterations of collagen metabolism present in heart failure promote the fibrotic substrate for the development of atrial fibrillation. Myocardial collagen I synthesis and degradation can be assessed indirectly by the circulating biomarkers carboxy-terminal propeptide (PICP) and carboxy-terminal telopeptide (CITP), respectively. Design: We examined myocardial collagen type I metabolism ...
Pecha Simon S Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, - - 2014
Systemic inflammation may contribute to heart failure. PGE2 was recently suggested to mediate inflammation-induced impairment of cardiac function by desensitizing the murine heart to isoprenaline. Given the magnitude of the reported effect and the potential relevance, we sought to reproduce it in the human heart. Human trabeculae were prepared from ...
Shu-Ping Tian T Department of Radiology,General Hospital of PLA,Beijing 100853,China; Department of Radiology,3Department of Endocrinology,Navy General Hospital of PLA,Beijing - - 2014
Objective To assess the value of preoperative coronary computed tomographic angiography(CCTA)in the detection of coronary artery disease(CAD)in patients planned to undergo non-cardiac surgery at intermediate or high risk to avoid unnecessary invasive coronary angiography(ICA). Methods The study protocol was approved by our institutional review board and informed consent was given. ...
Leemasawat Krit K Cardiovascular Unit, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, - - 2014
Left ventricular-to-right atrial communication, known as Gerbode defect, is rare. However, right ventricular-to-left atrial communication is much rarer. We present a case of a middle-aged woman with a past history of primum atrial septal defect surgery who presented with dyspnea on exertion. Echocardiographic studies showed dehiscence of the pericardial atrial ...
Tölli Marja A MA Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, FI-90014 Oulu, - - 2014
Myocardial infarction (MI), commonly known as a heart attack, is the irreversible necrosis of heart muscle secondary to prolonged ischemia, which is an increasing problem in terms of morbidity, mortality and healthcare costs worldwide. Along with the idea to develop nanocarriers that efficiently deliver therapeutic agents to target the heart, ...
Mohite Prashant N PN Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK, - - 2014
Arthrogryposis multiplex congenita (AMC) is characterized by contractions of multiple joints present at birth. AMC is rarely associated with cardiomyopathy. We present a case of a young man with dilated cardiomyopathy associated with AMC admitted with rapidly deteriorating severe heart failure who was offered left ventricular assist device as a ...
Cavalli Giulio G aDepartment of Internal Medicine and Clinical Immunology bDepartment of Cardiology cDepartment of Radiology, IRCCS San Raffaele Scientific Institute, Milan, - - 2014
Almost invariably associated with chronic HCV infection, cryoglobulinemic vasculitis is a small-vessel vasculitis commonly affecting the skin, kidneys, and peripheral nervous system. Cardiac involvement, possibly due to cardiac microcirculation involvement, is an utterly rare and severe complication. We describe a case of hypertrophic cardiomyopathy secondary to cryoglobulinemic vasculitis. Evaluation with ...
Martins Telma T Mass Spectrometry Group, QOPNA, Department of Chemistry, University of Aveiro, - - 2014
Cardiac cachexia is a serious complication of chronic heart failure, characterized by significant weight loss and body wasting. Chronic heart failure-related muscle wasting results from a chronic imbalance in the activation of anabolic or catabolic pathways, caused by a series of immunological, metabolic, and neurohormonal processes. In spite of the ...
Zangrando J J Centre de Recherche Public - Santè, Luxembourg, - - 2014
Long non-coding RNAs (lncRNAs) constitute a novel class of non-coding RNAs. LncRNAs regulate gene expression, thus having the possibility to modulate disease progression. In this study, we investigated the expression of lncRNAs in the heart after myocardial infarction (MI). Adult male C57/BL6 mice were subjected to coronary ligation or sham ...
Burke N N Hatter Cardiovascular Institute, London, United - - 2014
Cardiac-specific ablation of both Mfn1 and Mfn2 in the adult heart results in mitochondrial fragmentation and a lethal cardiomyopathy after about 6 weeks. The effect of combined Mfn1 and Mfn2 deletion on the susceptibility to acute ischemia-reperfusion injury (IRI) and subsequent calcium overload is not known, and is investigated in ...
Mavroidis M M Biomedical Research Foundation Academy of Athens, Greece, Athens, - - 2014
Inflammation may contribute to disease progression in arrhythmogenic cardiomyopathy (AC) however, its role in this process is unresolved. Our goal was to delineate the pathogenic role of the complement system in a new animal model of AC and its involvement in human disease. By cardiac histology, echocardiography, and electrocardiography we ...
Gonzalez Tendero A A Hospital Clinic, IDIBAPS, Department of Maternal-Fetal Medicine, Barcelona, - - 2014
While cardiomyocytes have a limited ability to shorten, the heart efficiently pumps a large volume-fraction thanks to a complex cell organisation in a 3D fibre structure. Such information is essential to understand diseases. CT/MRI provide structural information, however, their resolution is too low to study cellular mechanics in detail. Microscopy ...
Mohl W W Cardiac Surgery Medical University Vienna, Vienna, - - 2014
We have previously reported that Pressure controlled Intermittent Sinus Coronary Occlusion (PICSO) - a coronary sinus intervention, applied primarily to reduce myocardial injury by redistributing flow into underperfused zones and inducing washout clearing the ischemic/reperfused microcirculation, is able to enhance the proliferation of human fibroblasts in culture. To test whether ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The importance of apoptosis in cell death following ischemia and reperfusion has been demonstrated in vivo rodent modelsA potential strategy to alleviate cardiac I/Ri is to exploit the potent anti-inflammatory and cytoprotective effects of carbon monoxide (CO) by application of so-called CO-releasing molecules (CORMs). Here, we assessed whether CO released ...
Breckwoldt K K University Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, Hamburg, - - 2014
Myocardial infarction causes unrecoverable loss of cardiomyocytes. Engineered heart tissue (EHT) is an in vitro model of three-dimensional, force generating cardiomyocyte network with morphological and functional similarity to native heart tissue. In this study we transplanted EHTs from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CM) on cryo-injured guinea pig ...
Salatzki J J German Center for Cardiovascular Research, CCR, Institute of Pharmacology, Charité, Berlin, - - 2014
Myocardial metabolism undergoes a change in response to pathological hypertrophy, characterized by increased reliance on glucose oxidation, decreased free fatty acid oxidation, and a loss of metabolic flexibility. Cardiac metabolism is determined by whole-body metabolism and influenced by other organs such as adipose tissue. However, the molecular interaction between adipose ...
El Ghannudi S S Civil Hospital of Strasbourg, Strasbourg, - - 2014
To determine specific clinical, ECG, echocardiography and cardiac magnetic resonance imaging (CMR) features of fabry disease cardiomyopathy (FCM) in comparison to FD patients without cardiac involvement (N-FCM). We retrospectively included sixty height subjects, thirty-four patients with FD and thirty-four normal (N) subjects between 2004 and 2013. Detailed demographic, clinical, any ...
Kancirova I I Institute for Heart Research, Slovak Academy of Science, Bratislava, Slovak - - 2014
Myocardium heavily depends on the oxidative generation of energy that requires involvement of functional mitochondria. These organelles were recently shown to participate also in the mechanisms of cardioprotection induced by ischemic preconditioning. Based on the previous findings of increased myocardial resistance to ischemia, it could be assumed that mitochondria and ...
Nemeth Z Z University of Pecs, Medical School, Pathophysiology and Gerontology, and Szentagothai Research Centre, Pecs, - - 2014
Pericardial fluid (PF) contains biologically active substances, such as the L-arginine and its methylated derivative asymmetric dimethylarginine (ADMA). L-arginine is the substrate of nitric oxide synthase (NOS) producing NO, which has been implicated in cardiac remodeling, whereas ADMA interferes with NO bioavailability. Thus we hypothesized that L-arginine and ADMA present ...
Pianca N N Department of Biomedical Sciences, Padova, - - 2014
Cardiac Sympathetic Neurons (cSNs) densely innervate the myocardium and operate physiologically both as short term enhancers of cardiac function, and as constitutive regulator of cardiomyocyte (CM) size, by controlling proteolysis through the β2-AR/FOXO3/MuRF-1 dependent signaling axis (1). The density of cSNs decreases progressively from the epi- to the endocardium. We ...
Perera R K RK Heart Research Center Gottingen, Georg-August University, Department of Cardiology and Pneumology, Gottingen, - - 2014
Atrial natriuretic peptide (ANP) is a well-known vasodilatory factor and crucial hormone for adaptation to increased blood pressure. ANP plasma levels rise upon elevated cardiac afterload during aortic stenosis and, via guanylyl cyclase A, stimulate cardiomyocyte cGMP levels. Cardiac cGMP is considered as a protective second messenger which counteracts detrimental ...
Jayaram R R University of Oxford, Cardiovascular Medicine, Oxford, United - - 2014
The mechanisms responsible for myocardial stunning after cardiac surgery are only partially understood, although ischemia - reperfusion (IR) injury associated with cardio pulmonary bypass (CPB) may play an important role. Reactive oxygen species and nitric oxide have been implicated in both myocardial injury and cardio protection suggesting that identification of ...
Rutkovskiy A A University of Oslo, Institute of Basic Medical Sciences, dept. Physiology, Oslo, - - 2014
Bone morphogenetic protein-2 (BMP2) is known for its wide role in embryonic heart development, encompassing the differentiation of cardiomyocytes, vascularization, valvulogenesis and connective tissue formation. However, BMP2 function in the adult heart is unknown. Recent work indicates that other BMP family members may be involved in myocardial remodeling. We hypothesized ...
Gomez Salinero J M JM National Centre for Cardiovascular Research (CNIC), Madrid, - - 2014
Embryonic stem cells (ESCs) have the ability to proliferate indefinitely in culture, and to differentiate into all embryonic lineages. Although the transcriptional program that coordinates pluripotency has been progressively unveiled during the past few years, the signalling pathways that regulate early differentiation events are not completely understood. We have recently ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The proinflammatory cytokines may mediate myocardial dysfunction associated with myocardial infarction, severe congestive heart failure, and sepsis. A growing body of evidence suggests that inflammatory mediators could play a crucial role in ischemia-reperfusion injury. Furthermore, ischemia-reperfusion not only results in the local transcriptional and translational upregulation of cytokines but also ...
Jacques D D University of sherbrooke, anatomy and cell biology, Sherbrooke, - - 2014
Cardiomyopathy in general is defined as a disease of the heart muscle. The purpose of this study is to test the hypothesis that sodium-hydrogen exchanger (NHE1) abnormality is a common cause of cardiac and vascular failures in hereditary cardiomyopathy of the hamster. We verified whether heart failure is accompanied by ...
Hadi N R NR Kufa College of Medicine, Kufa, - - 2014
The importance of apoptosis in cell death following ischemia and reperfusion has been demonstrated in vivo rodent models,. Thyroid hormone can have positive effects on the cardiovascular system but its therapeutic potential is limited secondary to its adverse effects. DITPA has been shown to reduce pathologic remodeling and improve cardiac ...
Syeda F F University of Birmingham, Cardiovascular Sciences, Clinical and Experimental Medicine, Birmingham, United - - 2014
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death in young athletes. Loss-of-function mutations of desmosomal proteins including plakoglobin are linked with ARVC and ventricular arrhythmias in trained mice. Intensive endurance training increases atrial arrhythmias in rats. We tested endurance-trained heterozygous plakoglobin deficient (Plako+/-) mice for ...
Baysa A A University of Oslo, Institute of Basic Medical Sciences (IMB), Department of Physiology, Oslo, - - 2014
Heart failure is a growing problem worldwide. Cardiac remodeling, which features aseptic inflammation, metalloproteinase (MMP) activation and induction of matricellular proteins, contributes to heart failure progression after myocardial infarction (MI). The ShcA gene encodes three isoforms: p46-, p52- and p66ShcA, which are crucial for embryonic development of the heart. The ...
Lucas A A Inserm-UPS U1048, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse, - - 2014
Postinfarction remodeling is accompanied and influenced by perturbations in oxidative stress status and MAPK signaling. The Growth arrest and DNA-damage-inducible 45 (Gadd45) proteins are small acidic proteins involved in modulation of MAPK activities. Despite its relationship with p38 MAPK and intense interest in the cancer field, little is known about ...
Skyschally A A University of Essen Medical School, Institute for Pathophysiology, Essen, - - 2014
Remote ischemic preconditioning (RIPC), i.e. brief episodes of ischemia/reperfusion in a remote organ, protects the heart against infarction after myocardial ischemia/reperfusion. However, the transfer of protection from the remote ischemic/reperfused organ to the heart is still not understood. Here we address the transfer of a blood-borne cardioprotective factor from a ...
Van Hout G P J GP University Medical Center Utrecht, Division Heart and Lungs, Experimental Cardiology, Utrecht, - - 2014
Revascularization after myocardial infarction (MI) induces a strong inflammatory response resulting in an increase of circulating neutrophils. Neutrophil quantities have found to be a good predictor for future adverse events. In this study, we hypothesized that the extent of morphological changes in circulating neutrophils also reflects the myocardial damage after ...
Horckmans M M Ludwig-Maximilians University, Institute for Cardiovascular Prevention (IPEK), Munich, - - 2014
Neutrophils contribute to tissue damage after acute myocardial ischemia and reperfusion, but their role in infarct healing is less well understood. Because neutrophil-derived granule proteins mediate classical monocyte recruitment in acute inflammation, we hypothesized that neutrophil depletion during the acute inflammatory phase will improve infarct healing by reducing the proinflammatory ...
Van Lier Mgjtb M Academic Medical Center of Amsterdam, Department of Biomedical Engineering & Physics, Amsterdam, - - 2014
Myocardial tissue ischemia may be mitigated by a well-developed coronary collateral circulation. Only few detailed 3D data are available of the entire human coronary arterial tree. Here, high-resolution reconstructions of the coronary vasculature of two human hearts were quantitatively analyzed. Two hearts became available through autopsy: heart #1 (64 years, ...
Gonzalez Tendero A A Hospital Clinic, IDIBAPS, Department of Maternal-Fetal Medicine, Barcelona, - - 2014
Intrauterine growth restriction (IUGR) is associated with prenatal changes in cardiac shape and function that persist in childhood and may be associated to an increased cardiovascular mortality in adulthood. Ultrasound and MRI provide information at organ level, but their resolution is too low. Microscopy provides detail at cellular and subcellular ...
Fernandez-Jimenez R R National Centre for Cardiovascular Research (CNIC), Epidemiology, Atherothrombosis and Imaging Department, Madrid, - - 2014
Myocardial infarct size estimation using biomarkers -creatine kinase (CK) and troponin (cTn) - is commonly used as the primary endpoint in many experimental studies and clinical trials. We recently described for the first time in a retrospective study that peak of cTnI could overestimate infarct size in presence of left ...
Avolio E E University of Udine, Department of Medical and Biological Sciences, Udine, - - 2014
Cellular senescence associated with ageing and disease hampers the functional properties of human c-Kit+ Cardiac Stem Cells (CSC) in vitro. Aim of the study was to identify molecular mechanisms associated with CSC senescence and to pharmacologically modulate this latter, at the aim to improve the therapeutic potential of CSC in ...
Iaccarino D D University of Padova, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Padua, - - 2014
The gene Coiled Coil Domain Containing 80 (Ccdc80) is highly expressed in the hearts of vertebrates and its role is well defined in tumor suppression, glucose homeostasis and adipocyte differentiation. Our aims are to define its functional role during embryonic development and in cardiomyopathies. We used 3 different models: 1. ...
Kulaveerasingam D D King's College London, Randall Division of Cell and Molecular Biophysics, London, United - - 2014
Hypertrophy and hyperplasia play key roles in the growth of heart muscle. Following formation of the zebrafish heart tube at one day post fertilisation (dpf), it is currently thought that cell addition at the poles of the heart, with little proliferation of cardiomyocytes, results in growth until 2 dpf. From ...
Perez-Pomares J M JM University of Málaga, Málaga, - - 2014
Myocardial infarction is a prevalent cardiovascular disease. Mechanisms of repair in the post-infarcted heart include a progressive fibrosis that severely affects cardiac performance, eventually leading to cardiac failure. Cardiac fibrosis in the context of ventricular remodeling after infarction depends on fibroblasts of the cardiac interstitium (cardiac fibroblasts), a heterogeneous population ...
Constantin M M Electrophysiology and Heart modeling Institute (IHU-Liryc), Inserm U1045, University of Bordeaux, Pessac-Bordeaux, - - 2014
Cardiac gap junctions display distinct electrical properties in the different tissues that ensure the coordinated propagation of the action potential. They are clusters of intercellular gap junction channels (GJC) composed of connexins (Cxs) Cx40, Cx43, Cx45 and Cx30.2, which exhibit specific pattern of expression in the healthy heart. Importantly, in ...
Miskolczi G G University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have evidence that rapid cardiac pacing preserves gap junction (GJ) function by preventing the structural alterations that occur during ischaemia, 24h later; a mechanism which play a role the pacing-induced delayed protection against arrhythmias. Purpose: The present study has now examined whether closing of GJs prior to ischaemia with ...
Revnic C R CR C.C.Iliescu Cardiology Dpt, Bucharest, - - 2014
Heart muscle is largely dependent on uninterrupted blood flow, which guarantees delivery of substrates and washout of harmful products of metabolism. During aging, a lot of degenerative changes occur at the levels of all organs and heart is not an exception. Ischemia is a frequent phenomenon associated with aging and ...
Gonczi M M University of Szeged, Department of Pharmacology and Pharmacotherapy, Szeged, - - 2014
We have previously reported that rapid cardiac pacing preserves the function of gap junction channels (GJ) during ischaemia and reperfusion, 24h later. This result has suggested a role for these channels in the delayed antiarrhythmic protection. The present study was designed to provide further evidence to this relationship using carbenoxolone ...
Louwe Mc M Leiden University Medical Center, Dept. Endocrinology and Metabolic Diseases, Einthoven Laboratory for Experimental Vascular Medicine, Leiden, - - 2014
Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signalling domain that competitively inhibits TLR4-signalling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signalling, would lead ...
Baranyai T T Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, - - 2014
Remote ischemic preconditioning (RIPC) of the heart (i.e. brief ischemia/reperfusion cycles, subjected to a remote organ or a remote area, reduce the consecutive damage of a sustained cardiac ischemia. Although, its mechanism has been investigated thoroughly, exact interorgan transfer mechanisms of cardioprotection by RIPC are required to be further investigated. ...
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