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Chandorkar Aditya A Department of Internal Medicine, Einstein Medical Center, Philadelphia, - - 2014
Takotsubo cardiomyopathy is described as transient hypokinesis of the apical and mid-segments of the left ventricle with hypercontractile basal segments triggered by emotional or physical stress. Variants with basal hypokinesis and apical hyperkinesis have been described, as well as simultaneous involvement of the right ventricle (RV). Proposed mechanisms include myocardial ...
Grazioli G G Group of Sports Cardiology, Arrhythmia Section and Cardiac Imaging Section, Hospital Clinic, Thorax Institute, Barcelona, Catalonia, - - 2014
Premature ventricular complex are common findings in the exam of many athletes. There is no extensive scientific evidence in the management of this situation particularly when associated with borderline contractile function of the left ventricle. In this case report, we present a 35-year-old asymptomatic healthy athlete with high incidence (over ...
Kim Hyun-Wook HW Department of Internal Medicine, Chosun University School of Medicine, 375 Seo-suk dong, Dong-Gu, Gwangju, 501-759, Republic of - - 2014
The aim of this study was to evaluate the prognostic value of serum total bilirubin on the development of adverse outcomes after percutaneous coronary intervention (PCI) besides high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP). Serum total bilirubin, hs-cTnT, and NT-proBNP were analyzed in 372 patients ...
Herrmann Joerg J From the Division of Cardiovascular Diseases and Department of Internal Medicine and Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, MN (J.H., R.J.L., A.S.J., D.R.H., C.S.R.); and Cardiac Research Centre, St George's, University of London, London, United Kingdom - - 2014
There is controversy about the diagnostic and prognostic significance of percutaneous coronary intervention-related myocardial infarction, especially with the use of cardiac troponin T (cTnT). This analysis was designed to address the question of the presence and the level of a prognostic cTnT threshold. We evaluated 5268 consecutive patients who underwent ...
Djordjevic Dikic Ana A Clinical Center of Serbia, Cardiology Clinic, Medical School, University of Belgrade, Koste Todorovica 8, 11000 Belgrade, Serbia - - 2014
The aim of the study was to assess the value of coronary flow reserve (CFR) for predicting improvement of left ventricular function after cardiac resynchronization therapy (CRT). Study population included 40 patients (mean age 58 ± 9 years) with heart failure (ejection fraction 25, 7 ± 5, 4%) and QRS ...
Fuller Maren Y MY Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, - - 2014
A 15-year-old African-American female with a 4-month history of sporadic rapid heartbeat and fatigue was found pulseless and apneic in her residence. At autopsy, patchy scarring was diffuse throughout the circumference of the left ventricle of the heart. Microscopically, the myocardium had diffuse infiltration of rhabdomyoma-like cells with significant associated ...
Loomba Rohit S RS Department of Cardiology,Children's Hospital of Wisconsin,Milwaukee,Wisconsin,United States of - - 2014
Antiepileptic medications have been reported to cause disturbances in cardiac conduction. Lacosamide decreases seizure burden by modulating sodium channels. Although it has been demonstrated to have few side effects, there have been reports of clinically significant cardiac conduction disturbances. We report the case of a child with hypoplastic left-heart syndrome ...
Sun Ying Y Department of Anesthesiology & Pediatric Clinical Pharmacology Laboratory, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
We evaluated the use of bioreactance-based noninvasive cardiac output (CO) monitoring technique (NICOM(™) , CONICOM ) in pediatric patients with or without ventricular septal defect (VSD) during anesthesia induction to determine its agreement with the measurements assessed by echocardiography (echo, COECHO ). Twenty-eight pediatric patients with normal heart anatomy (group ...
Ma Lining L 1] Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA [2] Cardiovascular Department, Hainan Provincial People's Hospital, Hainan, - - 2014
A specific role for Akt1 in events following myocardial infarction (MI) and ischemia/reperfusion (I/R) injury is not known. We aimed to determine whether Akt1 deletion in in vivo mouse models of MI and after ischemia I/R injury would alter myocyte survival, cardiac function, and fibrosis. Akt1(+/+) and Akt1(-/-) mice were ...
Saxena Amit A 1New York University School of Medicine, Department of Medicine, Division of Rheumatology 2New York Medical College, Department of Pediatrics, Division of Pediatric - - 2014
Transplacental transfer of maternal anti-Ro and/or anti-La autoantibodies can result in fetal cardiac disease including congenital heart block and cardiomyopathy, called cardiac Neonatal Lupus (NL). Thousands of women are faced with the risk of cardiac NL in their offspring, which is associated with significant morbidity and mortality. There are no ...
Panovsky Roman R aDepartment of Cardiovascular Diseases, International Clinical Research Center, St. Anne's Faculty Hospital and Masaryk University, Brno bDepartment of Interventional Radiology, Hospital Trinec-Podlesi, Trinec cDepartment of Medical Imaging, St Anne's Hospital, Masaryk University, Brno, Czech Republic dInstitute of Normal and Pathological Physiology and Center of Excellence for Regulatory Role of Nitric Oxide in Civilization Diseases, Slovak Academy of Sciences, Bratislava, Slovak - - 2014
The left atrium plays an integral role in cardiac performance. Data regarding the left atrial size, volume, function, and structure are clinically important in the management of patients with different diagnoses. Moreover, left atrial size and function were recognized as robust predictors of poor outcome across a broad range of ...
Yuan Ming-Jie MJ Dept of Cardiology, Wuhan Univ, Renmin Hospital, Wuhan 430060, Hubei Province, P.R. - - 2014
Ghrelin is a novel growth hormone-releasing peptide, which has been shown to exert beneficial effects on cardiac function and ventricular remodeling. The present study aimed to investigate the expression of ghrelin and the growth hormone (GH) secretagogue receptor 1a (GHSR-1a), and the association with cardiac remodeling in rats with myocardial ...
Hua Lisa L LL Cardiovascular Research - - 2014
Coordinated contraction of the heart is essential for survival and is regulated by the cardiac conduction system. Contraction of ventricular myocytes is controlled by the terminal part of the conduction system known as the Purkinje fiber network. Lineage analyses in chickens and mice have established that the Purkinje fibers of ...
Uriarte Diego Salerno DS aDivision of Cardiology, Department of Medicine, Surgery and Dentistry, San Paolo Hospital bDivision of Cardiac Surgery IRCCS, Policlinico San Donato Hospital, San Donato Milanese, and Faculty of Medicine, University of Milan, Milan, - - 2014
We report the case of a young woman with an acute myocardial infarction secondary to coronary embolization from a left atrial myxoma, as unusual presentation of a cardiac tumor.We also describe the role of transthoracic echocardiograpy in the multidisciplinary approach to diagnosis and treatment of this life-threatening condition.
Kikuchi Kazu K Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, NSW 2052, Australia. Electronic address: - - 2014
The adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, but recent findings have challenged this dogma. A modified view assigns the mammalian heart a measurable capacity for regeneration throughout its lifetime, with the implication that endogenous regenerative capacity can be therapeutically stimulated ...
Lanham Kevin A KA Department of Pharmaceutical Sciences, 777 Highland Avenue, University of Wisconsin, Madison, WI - - 2014
Exposure of zebrafish embryos to 2,3,7,8-tetrachlorordibenzo-p-dioxin (TCDD) activates the zebrafish aryl hydrocarbon receptor 2 (AHR) to produce developmental and cardiovascular toxicity. AHR is found in the heart; however, AHR activation by TCDD is not confined to the heart, and occurs throughout the organism. In order to understand the cause of ...
Schindler Yocheved L YL Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, - - 2014
Embryonic heart formation requires the production of an appropriate number of cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of lost cardiomyocytes. The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in promoting cardiomyocyte formation. It is unclear, however, whether Hand2 plays an instructive or permissive role ...
Costa Marco A MA University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH - - 2014
-Left ventricle (LV) remodeling after anterior wall myocardial infarction leads to increased LV volumes, myocardial stress, and ultimately heart failure (HF). Treatment options are limited for these high-risk HF patients. A study was conducted to assess safety and feasibility of a percutaneous ventricular restoration (PVR) therapy using the Parachute(®) device ...
Scali Maria Chiara - - 2014
There is increasing interest in guiding Heart Failure (HF) therapy with Brain Natriuretic Peptide (BNP) or N-terminal prohormone of Brain Natriuretic Peptide (NT-proBNP), with the goal of lowering concentrations of these markers (and maintaining their suppression) as part of the therapeutic approach in HF. However, recent European Society of Cardiology ...
Smolensky Michael H MH Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, 1 University Station C0800, Austin, TX 78712-0238, USA. Electronic address: - - 2014
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24 h patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ...
Graça Bruno B Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal, - - 2014
The left atrium (LA) modulates left ventricular filling through reservoir, conduit and booster pump functions. Only limited data exist on LA involvement in type 2 diabetes mellitus (DM2). This study sought to assess LA function in asymptomatic DM2 with cardiac MRI. We hypothesized that cardiac MRI can detect LA dysfunction ...
Padeletti Luigi L aArrhythmology, A.O.U. Careggi, Firenze, Florence bCardiology Division, Sant'Anna Hospital, Como cElectrophysiology, Spedali Civili, Brescia dCardiology Division, Policlinico Casilino, Rome eUOSD Electrophysiology, Vincenzo Monaldi Hospital, Naples fCardiology Division, Multimedica Clinic, Milan gCardiology Division, San Filippo Neri Hospital, Rome hCardiology Division, Santa Croce Hospital, Cuneo iUOC Cardiology, Mater Salutis Hospital, Legnago, Verona jCardiology, University of Trieste, Trieste, Italy kBiotronik AG, Baar, Switzerland lBiotronik Italia, Milan, - - 2014
Heart failure is a leading cause of hospitalization and a significant medical burden in our society. Implantable medical devices are nowadays established therapies in heart failure patients that not only provide cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillators (ICDs) therapy but are also able to continuously and remotely monitor ...
Vausort Melanie M Laboratory of Cardiovascular Research, Centre de Recherche - - 2014
Rationale:Long non-coding RNAs (lncRNAs) constitute a novel class of non-coding RNAs that regulate gene expression. Although recent data suggest that lncRNAs may be associated with cardiac disease, little is known about lncRNAs in the setting of myocardial ischemia. Objective: To measure lncRNAs in patients with myocardial infarction (MI). Methods and ...
Sun Huaqun H Department of Electrocardiogram, Zhejiang Provincial People's Hospital, HangZhou, PR, - - 2014
We present a rare case of various conduction defects involving the left anterior, septal, and posterior branch in one patient. The different degrees of block of anterior, septal, and posterior fascicular of the left bundle branch indicate pathological changes in left ventricle. However, the values of this electrocardiographic presentation indicating ...
Sherazi Saadia S Cardiovascular Division, University of Rochester Medical Center, Rochester, New York. Electronic address: - - 2014
Low pulse pressure (PP) is associated with poor outcome in hospitalized patients with systolic heart failure (HF). However, the relation between PP and response to cardiac resynchronization therapy with defibrillator (CRT-D) is unknown. We aimed to evaluate the relation between preimplantation PP and echocardiographic response to CRT-D and subsequent clinical ...
Mabote Thato T Department of Academic Cardiology, Hull York Medical School, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, - - 2014
Monitoring a patient's hemodynamic status may be a revolutionary way to aid a 'health maintenance' strategy in which the physician strives to therapeutically keep the patient in an ideal hemodynamic range. Currently, home telemonitoring employs a 'crisis-prevention' approach. This strategy is still based on easily acquired measures such as heart ...
Fang Fang F Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, and Institute of Vascular Medicine, The Chinese University of Hong Kong, Hong - - 2014
Left atrial structural and functional changes in heart failure are relatively ignored parts of cardiac assessment. This review illustrates the pathophysiological and functional changes in left atrium in heart failure as well as their prognostic value. Heart failure can be divided into those with systolic dysfunction and heart failure with ...
Leong Darryl P DP Department of Medicine, Division of Cardiology, McMaster University Hamilton, ON, - - 2014
This review of emerging approaches to left atrial imaging in atrial fibrillation is relevant because there has been considerable recent development in the noninvasive characterization of left atrial structure and function. Concurrently, the identification and treatment of atrial fibrillation and the prevention of thromboembolism are evolving. Thus, it is timely ...
Bickel Amitai A Department of Surgery, Bar Ilan University, Israel; Department of Western Galilee Medical Center, Nahariya; and the Faculty of Medicine of the Galilee, Bar Ilan University, - - 2014
Pneumatic leg sleeves are widely used following prolonged operations for prevention of venous stasis. In healthy volunteers they increased cardiac function. We evaluated the hemodynamic effects and the safety of intermittent sequential pneumatic leg sleeves (ISPC) in patients with chronic congestive heart failure (CHF). We studied 19 patients with systolic ...
Randhawa Arpandeep A Department of Anatomy, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
Pulmonary vein (PV) isolation with catheter ablation in treating atrial fibrillation carries the risk of injury to phrenic nerve (PN). Left PN (LPN) stimulation continues to be one of the common complications of transvenous left ventricular lead placement during cardiac resynchronization therapy (CRT). In 30 formalin-fixed cadavers, spatial relationship of ...
Park Yeonjeong Y Cardiology Division, Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Republic of - - 2014
Premature ventricular complex (PVC) has been regarded as benign; however, when frequent, the arrhythmia can induce left ventricular (LV) systolic dysfunction. Meanwhile, the influence of PVCs on cardiac structural remodeling and functional change before occurrence of overt systolic heart failure has not been fully described. In this study, we attempted ...
DeKoninck Philip P Fetal Medicine Unit, Department of Obstetrics and Gynecology, University Hospitals Leuven & Cluster Organ Systems, Department of Development and Regeneration, KU Leuven, Leuven, - - 2014
To evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking. Case-control study assessing cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected ...
Fu Qi Q Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: - - 2014
Syncope is a common clinical condition occurring even in otherwise healthy people without underlying cardiovascular disease. Neurally mediated syncope is by far the most common cause of syncope in individuals without any structural heart disease. Based on traditional wisdom, loss of sympathetic tone with relaxation of vascular smooth muscle is ...
Bergmann Olaf O Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. Electronic address: - - 2014
A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance ...
Thomas Joseph L JL Division of Cardiology, Harbor UCLA Medical Center, Torrance, California. Electronic address: - - 2014
The aim of this study was to evaluate the treatment and outcomes of patients with ST-segment elevation myocardial infarctions complicated by out-of-hospital cardiac arrest in a regional system of care. In this retrospective study, the effect of the absence of an initial shockable arrest rhythm was analyzed. The primary end ...
Link Mark S MS Tufts Medical Center, Cardiac Arrhythmia Center, Boston, Massachusetts. Electronic address: - - 2014
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with sudden cardiac death. However, the selection of patients for implanted cardioverter-defibrillators (ICDs), as well as programming of the ICD, is unclear. The objective of this study was to identify predictors, characteristics, and treatment of ventricular arrhythmias in patients with ARVC. The Multidisciplinary Study ...
Hwang Sung Ho SH Department of Radiology, Anam Hospital College of Medicine, Korea University, Seoul, South - - 2014
To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV ...
Ishikawa Kiyotake K Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, - - 2014
Cardiac gene therapy has emerged as a promising option to treat advanced heart failure. Advances in molecular biology and gene targeting approaches are offering further novel options for genetic manipulation of the cardiovascular system. The aim of this study was to improve cardiac function in chronic heart failure by over-expressing ...
Li Jun J 1] Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China [2] Institute of Medical Genetics, Tongji University, Shanghai 200092, - - 2014
Pathological cardiac hypertrophy is an inevitable forerunner of heart failure. Regardless of the etiology of cardiac hypertrophy, cardiomyocyte mitochondrial alterations are always observed in this context. The translocases of mitochondrial outer membrane (Tom) complex governs the import of mitochondrial precursor proteins to maintain mitochondrial function under pathophysiological conditions; however, its ...
Matsumoto Takashi T Heart Institute, Cedars-Sinai Medical - - 2014
Recent advances in structural heart intervention have produced increasing demand for transseptal access, which was first introduced as a diagnostic tool to directly measure left atrial pressure. Transseptal access allows safe and adequate approach to the left atrium and surrounding structures. Percutaneous transcatheter mitral valve repair using the MitraClip device ...
Saito Tomohiro T Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany - - 2014
A left ventricular pseudoaneurysm develops when myocardial rupture is contained by the pericardium. Although left ventricular pseudoaneurysm has been a topic of discussion since the pioneering days of open heart surgery, it still remains a technical challenge in reconstructive cardiac surgery. Reoperation following pseudoaneurysm repair is also frequent. We report ...
Rodrigues Fernando - - 2014
It has been suggested that exercise training (ET) protects against the pathological remodeling and ventricular dysfunction induced by myocardial infarction (MI). However, it remains unclear whether the positive adjustments on baroreflex and cardiac autonomic modulations promoted by ET may afford a cardioprotective mechanism. The aim of this study was to ...
Ryckman Eva M EM Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI, 53792-3252, - - 2014
The purpose of this study was to determine if quantifying visceral adipose tissue (VAT) at CT in asymptomatic adults can predict the likelihood of future cardiac events. Subcutaneous and visceral fat volumes were obtained from abdominal CT utilizing a validated semi-automated software tool in 663 asymptomatic adults (mean age 57.3 years, ...
Yang Kai-Chien KC Lifespan Cardiovascular Research Center, the Warren Alpert School of Medicine, Brown University & Providence Veterans Administration Medical Center, Providence, RI & Department of Medicine, University of Illinois at Chicago, Chicago, - - 2014
-Genome wide association studies (GWAS) have revealed significant association of caveolin-1 (Cav1) gene variants with increased risk of cardiac arrhythmias. Nevertheless, the mechanism for this linkage is unclear. -Using adult Cav1(-/-) mice, we revealed a marked reduction in the left ventricular (LV) conduction velocity in the absence of myocardial Cav1, ...
Stárek Zdeněk Z 1st Department of Internal Medicine - Cardioangiology St. Anne's University Hospital Brno Pekarska 53 656 91 Brno Czech Republic. - - 2014
Atrial fibrillation is the most common sustained arrhythmia. Because of the sub-optimal outcomes and associated risks of medical therapy as well as the recent advances in non-pharmacologic strategies, a multitude of combined (hybrid) algorithms have been introduced that improve efficacy of standalone therapies while maintaining a high safety profile. Antiarrhythmic ...
Dietl Alexander A Department of Internal Medicine II, University Hospital Regensburg; Department of Genetic Epidemiology, University of - - 2014
Left and right atria show compelling differences regarding organogenesis and specific clinical diseases. In congestive heart failure (CHF), remodelling of the atria occurs leading to increased arrhythmogenic susceptibility and deterioration of clinical symptoms. We aimed to assess the basal left and right atrial molecular set-up and different chamber-specific atrial changes ...
Peng Hongmei H Henry Ford - - 2014
Thymosin β4 (Tβ4) promotes cell survival, angiogenesis, tissue regeneration and reduces inflammation. Cardiac rupture after myocardial infarction (MI) is mainly the consequence of excessive regional inflammation, whereas cardiac dysfunction after MI results from a massive cardiomyocyte loss and cardiac fibrosis. It is possible that Tβ4 reduces incidence of cardiac rupture ...
Conover Zacherie Z Sarver Heart Center, University of Arizona College of Medicine, Tucson, - - 2014
-Prior investigation of out-of-hospital cardiac arrest (OHCA) has raised the concern that ventricular fibrillation (VF) recurrence may be triggered by chest compression (CC) resumption. We investigated predictors of VF recurrence after defibrillation, including timing of CC resumption. -Patients with witnessed OHCA and initial rhythm of VF from an Utstein-style database ...
Picchi Andrea A aDepartment of Cardiology, Misericordia Hospital, Grosseto bDepartment of Medical and Surgical Critical Care, University of Florence, Florence, - - 2014
Therapeutic hypothermia has demonstrated to improve both survival and neurological outcome in patients who experienced an out-of-hospital cardiac arrest. Nevertheless, many aspects of its clinical application are still controversial. Current guidelines recommend to cool patients who survive a cardiac arrest due to either ventricular fibrillation or ventricular tachycardia, whereas the ...
Nardi Paolo P Cardiac Surgery Unit, Policlinico Tor Vergata, Tor Vergata University of Rome, Rome, - - 2014
To evaluate the fate of on-pump coronary artery bypass grafting (ON-pump CABG) vs. off-pump coronary artery bypass grafting (OP-CABG) surgery at mid-term follow-up. From January 2008 to December 2010, 369 patients underwent surgical myocardial revascularization by means of OP-CABG techniques (n = 166) or with ON-pump CABG (n = 203). ...
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