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Jordan Jennifer H JH From the Departments of *Internal Medicine (Section of Cardiology), †Biostatistical Sciences, ‡Biomedical Engineering, and §Radiology, Wake Forest School of Medicine, Winston-Salem, - - 2014
The objective of this study was to assess the frequency and prognostic utility of small, short-duration left ventricular myocardial perfusion defects during dobutamine cardiovascular magnetic resonance (DCMR) stress imaging. We performed first-pass contrast-enhanced DCMR at peak stress in 331 consecutively recruited individuals (aged 68 ± 8 years, 50% men) at ...
Fantinelli Juliana C JC Established Investigator of CONICET, Centro de Investigaciones Cardiovasculares, Universidad Nacional de La Plata, La Plata, Buenos Aires, - - 2014
Although the participation of the electrogenic sodium/bicarbonate cotransporter (NBCe1) in the recovery from an intracellular acid load is recognized, its role in ischemia-reperfusion is still unclear. Our objective was to assess the role of NBCe1 in reperfusion injury. We use selective functional antibodies against extracellular loop 3 (a-L3) and loop ...
Lim Soyeon S Severance Integrative Research Institute for Cerebral & Cardiovascular Disease, Yonsei University Health System, 50 Yonsei-ro, Seodamun-gu, Seoul 120-752, Republic of - - 2014
Myocardial Ca(2+) overload induced by ischemia/reperfusion (I/R) is a major element of myocardial dysfunction in heart failure. Phospholipase C (PLC) plays important roles in the regulation of the phosphoinositol pathway and Ca(2+) homeostasis in various types of cells. Here, we investigated the protective role of PLCδ1 against myocardial ischemia/reperfusion injury ...
Graham Ph P Cancer Care Centre, St George Hospital, University of New South Wales, Sydney, New South Wales, - - 2014
The purpose of this study was to evaluate the cardiac dosimetry delivered before and after routine 3D CT whole-breast radiotherapy planning, including cardiac contouring and the relevance of a 15-mm maximum myocardial depth (MMD) planning tolerance threshold. The PULp FICTion study permitted cardiac dosimetry comparisons for 140 patients (70 in ...
Cuypers Judith A A E JA Department of Cardiology, Erasmus MC, PO Box 2040, Rotterdam 3015 CE, The - - 2014
To describe long-term survival, clinical outcome and ventricular systolic function in a longitudinally followed cohort of patients after Mustard repair for transposition of the great arteries (TGA). There is serious concern about the long-term outcome after Mustard repair. This longitudinal single-centre study consisted of 91 consecutive patients, who underwent Mustard ...
Rassaf Tienush T Cardiology, Pulmonology, Angiology, University Hospital - - 2014
Remote ischemic preconditioning (rIPC) with short episodes of ischemia and reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the crosstalk between the remote site and the heart remain unclear in detail. To elucidate the ...
Narayanan Kumar K Cedars-Sinai Medical Center, Los Angeles, CA, - - 2014
Left ventricular hypertrophy (LVH) is associated with increased risk of sudden cardiac arrest (SCA); whether LVH diagnosed by 12-lead ECG versus echocardiogram conveys identical or distinct risk information has not been previously evaluated. To compare the association between ECG versus echocardiographic LVH and SCA in the community. In a large, ...
Adelstein Evan E University of Pittsburgh Heart and Vascular Institute, Pittsburgh, Pennsylvania. Electronic address: - - 2014
Pacemaker-dependent patients with left ventricular (LV) dysfunction benefit from upgrade to cardiac resynchronization therapy (CRT). Those at low risk for ventricular tachyarrhythmias may benefit similarly from a CRT-defibrillator or CRT-pacemaker. To determine if coronary artery disease (CAD), because of associated scar that supports reentry, predicts higher risk of appropriate shocks ...
Auricchio Angelo A Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, - - 2014
Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypothesized that the Physiological Diagnostic ...
Tarone Guido G Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Torino, - - 2014
The failing heart is characterized by complex tissue remodelling involving increased cardiomyocyte death, and impairment of sarcomere function, metabolic activity, endothelial and vascular function, together with increased inflammation and interstitial fibrosis. For years, therapeutic approaches for heart failure (HF) relied on vasodilators and diuretics which relieve cardiac workload and HF ...
Sallam Karim K Stanford Cardiovascular - - 2014
Advances in the understanding and treatment of cardiac disorders have been thwarted by the inability to study beating human cardiac cells in vitro. Induced pluripotent stem cells (iPSCs) bypass this hurdle by enabling the creation of patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). These cells provide a unique platform to study cardiac diseases ...
Zavadzkas Juozas A JA Medical University of South - - 2014
Myocardial infarction (MI) causes an imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) and is associated with adverse LV remodeling. A uniform reduction in TIMP-4 post-MI has been observed. Examine post-MI remodeling with cardiac restricted overexpression of TIMP-4, either through a transgenic or viral delivery approach. MI ...
Magrì Damiano D Department of Clinical and Molecular Medicine, Sapienza - - 2014
Background: Growing evidence suggests that late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) is an additive marker of disease severity, and possibly of arrhythmic risk, in hypertrophic cardiomyopathy (HCM). We investigated the possible relationship between LGE and markers of myocardial repolarization dispersion in HCM. Methods and Results: Eighty-five HCM outpatients underwent ...
Zhao Shu-Li - - 2014
Elevated midkine (MK) expression may contribute to ventricular remodeling and ameliorate cardiac dysfunction after myocardial infarction (MI). Ex vivo modification of signaling mechanisms in mesenchymal stem cells (MSCs) with MK overexpression may improve the efficacy of cell-based therapy. This study sought to assess the safety and efficacy of MSCs with ...
Codreanu I I Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, - - 2014
Objective: Obtaining new details of radial motion of left ventricular (LV) segments using velocity-encoding cardiac MRI. Methods: Cardiac MR examinations were performed on 14 healthy volunteers aged between 19 and 26 years. Cine images for navigator-gated phase contrast velocity mapping were acquired using a black blood segmented κ-space spoiled gradient ...
Sobrino Ayax A Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, - - 2014
To evaluate intra-procedural imaging with transesophageal echocardiography and angiography during left atrial appendage occlusion using the Amplatzer™ Cardiac Plug with regard to sizing and final device shape. Left atrial appendage ostium dimensions and diameter at a depth of 10mm from the ostium were measured by transesophageal echocardiography (0-180°) and angiography ...
Zellars Richard R Johns Hopkins Medical Institution, Baltimore, Maryland. Electronic address: - - 2014
Cardiac muscle perfusion, as determined by single-photon emission computed tomography (SPECT), decreases after breast and/or chest wall (BCW) irradiation. The active breathing coordinator (ABC) enables radiation delivery when the BCW is farther from the heart, thereby decreasing cardiac exposure. We hypothesized that ABC would prevent radiation-induced cardiac toxicity and conducted ...
Tsutsumi Yasuo M YM Department of Anesthesiology, University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan, - - 2014
Pharmacological preconditioning, including that with geranylgeranylacetone (GGA) and volatile anesthetics, has been shown to confer cardiac protection from ischemia/reperfusion injury although the mechanisms for this protection are poorly understood. Caveolins, integral membrane proteins that act as scaffolding proteins in caveolar membranes, localize molecules involved in cardiac protection. We have tested ...
Cao L L Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270, Dong An Road, 200032 Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, - - 2014
To analyse the risk factors associated with acute cardiotoxicity in HER2-positive breast cancer patients receiving concurrent trastuzumab and radiotherapy. Medical records of 45 breast cancer patients treated between 02/2009 and 02/2011 by concurrent trastuzumab and radiotherapy were collected. Radiation was delivered to the conserved breast or chest wall with or ...
Ruwald Anne Christine AC Department of Cardiology, Gentofte University Hospital, Copenhagen, - - 2014
Previous studies have shown substantially increased risk of cardiac arrhythmias and sudden cardiac death in post-myocardial infarction (MI) patients. However it remains difficult to identify the patients who are at highest risk of arrhythmias in the post-MI setting. The purpose of this study was to investigate if CHADS2 score (congestive ...
Shen Mark J MJ From Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, - - 2014
The autonomic nervous system plays an important role in the modulation of cardiac electrophysiology and arrhythmogenesis. Decades of research has contributed to a better understanding of the anatomy and physiology of cardiac autonomic nervous system and provided evidence supporting the relationship of autonomic tone to clinically significant arrhythmias. The mechanisms ...
Spiliopoulos Sotirios S Department of Surgical Therapy of End-stage Heart Failure and Mechanical Circulatory Support, Heart and Vascular Center Duisburg, Duisburg, - - 2014
The SynCardia total artificial heart is currently used as a bridge to transplantation therapy in cases of irreversible, acute or chronic, biventricular heart failure. We describe the implementation of this technology in the context of destination therapy in a patient with an end-stage heart failure on grounds of primary amyloidosis.
Sade Leyla Elif LE University of Pittsburgh, Pittsburgh, - - 2014
Response to cardiac resynchronization therapy is variable. The aim of this study was to test the hypothesis that left ventricular (LV) lead position in proximity to myocardial scar is associated with less favorable outcomes. A total of 149 patients were included in this substudy of the Speckle Tracking Assisted Resynchronization ...
Qin Fuzhong F Boston University School of - - 2014
Oxidative stress in the myocardium plays an important role in the pathophysiology of hemodynamic overload. The mechanism by which reactive oxygen species (ROS) in the cardiac myocyte mediate myocardial failure in hemodynamic overload is not known. Accordingly, our goals were to test whether myocyte-specific overexpression of peroxisomal catalase (pCAT) that ...
Welch Terrence D TD 1Section of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, and Geisel School of Medicine at Dartmouth, Hanover, - - 2014
-Constrictive pericarditis is a potentially reversible cause of heart failure that may be difficult to differentiate from restrictive myocardial disease and severe tricuspid regurgitation. Echocardiography provides an important opportunity to evaluate for constrictive pericarditis, and definite diagnostic criteria are needed. -Patients with surgically-confirmed constrictive pericarditis (n=130) at Mayo Clinic (2008-2010) ...
Rinaldi C Aldo CA Cardiac Department, St Thomas' Hospital, London, SE1 7EH, UK, - - 2014
A quadripolar left ventricular (LV) pacing can deliver multipoint pacing (MPP). It is unknown if this confers improved cardiac function compared to conventional cardiac resynchronization therapy (CRT). We aimed to characterize changes in acute cardiac contractility and hemodynamics with multisite left ventricular "multipoint" pacing (MPP) in a prospective multicenter study ...
Peters Tim T Experimental Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The - - 2014
Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts ...
Tanaka Koji K Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, - - 2014
Atrial fibrillation impairs left atrial appendage function and the thrombus formation in the left atrial appendage is a major cause of cardioembolic stroke. To evaluate the association between the volume of the left atrial appendage measured by real-time three-dimensional transesophageal echocardiography and presence of paroxysmal atrial fibrillation in patients with ...
Zafrir Nili N Nuclear Cardiology Unit, Rabin Medical Center, Beilinson Campus, 49100, Petah Tikva, Israel, - - 2014
Left ventricular (LV) dyssynchrony by phase analysis has been studied by myocardial perfusion imaging (MPI)-gated SPECT in patients with LV dysfunction in various clinical settings. We aimed to investigate the routine use of phase analysis with gated SPECT for predicting cardiac outcome. Patients referred to a tertiary medical center in ...
Li Qiaoling Q Department of Cardiology, Drum Tower Clinical Medical Hospital, Nanjing Medical University, Nanjing, - - 2014
MicroRNAs are involved in the regulation of various cellular processes, including cell apoptosis and autophagy. Expression of microRNA-99a (miR-99a) is reduced in apoptotic neonatal mice ventricular myocytes (NMVMs) subjected to hypoxia. We hypothesize that miR-99a might restore cardiac function after myocardial infarction (MI) by up-regulation of myocyte autophagy and apoptosis. ...
Seitz Stefanie S Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, - - 2014
A girl received an ABO incompatible heart transplantation (ABOiHTx) at the age of 3.5 years for failed univentricular palliation with protein losing enteropathy (PLE). She was born with a hypoplastic left heart syndrome and underwent multi stage palliation to a Fontan circulation at 2 ½ years of age. After the ...
Hestenes Siv M SM 1Intervention Centre, Oslo University Hospital, Oslo, Norway. 2Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway. 3Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 4KG Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway. 5Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 6Department of Emergency Medicine, Nordland Hospital, Bodø, Norway. 7University of Nordland, Bodø, Norway. 8Faculty of Health Sciences, University of Tromsø, Tromsø, - - 2014
Cardiovascular failure is an important feature of severe sepsis and mortality in sepsis. The aim of our study was to explore myocardial dysfunction in severe sepsis. Prospective experimental study. Operating room at Intervention Centre, Oslo University Hospital. Eight Norwegian Landrace pigs. The pigs were anesthetized, a medial sternotomy performed and ...
Verkuil Bart B Institute of Psychology, Leiden University. Electronic address: - - 2014
Excessive cardiac responses to stressful events are a risk factor for morbidity and mortality. Adverse cardiac responses are usually attributed to conscious negative stress and emotions. Yet, cardiac responses might also be affected by emotions that are not consciously reported. Here we tested this hypothesis. Sixty participants were randomly allocated ...
Gan Xiaohong Tracey XT 1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, - - 2014
-Probiotics are extensively used to promote gastrointestinal health and emerging evidence suggests that their beneficial properties can extend beyond the local environment of the gut. Here, we determined whether oral probiotic administration can alter the progression of post-infarction heart failure. -Rats were subjected to six weeks of sustained coronary artery ...
Ma Chun-Yan CY Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping, Shenyang, 110001, Liaoning, China, - - 2014
Myocardium viability in ischemic heart failure (HF) may affect the effect of cardiac resynchronization therapy (CRT). We hypothesized that longitudinal strain of 2D-STE, which reflects myocardium viability, can predict the response to CRT in patients with ischemic HF. 2D-STE was performed in 42 patients with HF, 1 week before and 1 year ...
Chamsi-Pasha Hassan H Head of Non-Invasive Cardiology, Department of Cardiology, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia, - - 2014
More than 23 million adults worldwide have heart failure (HF). Although survival after heart failure diagnosis has improved over time, mortality from heart failure remains high. At the end of life, the chronic HF patient often becomes increasingly symptomatic, and may have other life-limiting comorbidities as well. Multiple trials have ...
Yang Tiehong T 1Pat and Jim Calhoun Cardiology Center, University of Connecticut Medical Center, Farmington, - - 2014
-Heart failure (HF), despite continuing progress, remains a leading cause of mortality and morbidity. P2X4 receptors (P2X4R) have emerged as potentially important molecules in regulating cardiac function and as potential targets for HF therapy. Transgenic (Tg) P2X4R overexpression can protect against HF, but this does not explain the role of ...
Simon Jillian N JN Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, - - 2014
Significant advances in our understanding of the ability of nitric oxide synthases (NOS) to modulate cardiac function have provided key insights into the role NOS play in the regulation of excitation-contraction (EC) coupling in health and disease. Through both cGMP-dependent and cGMP-independent (e.g. S-nitrosylation) mechanisms, NOS have the ability to ...
Wang Jun J aDepartment of Molecular Physiology and Biophysics bProgram in Developmental Biology, Baylor College of Medicine, One Baylor Plaza cTexas Heart Institute, Houston, Texas, - - 2014
Myocardial injury and disease often result in heart failure, a major cause of death worldwide. To achieve myocardial regeneration and foster development of efficient therapeutics for cardiac injury, it is essential to uncover molecular mechanisms that will promote myocardial regeneration. In this review, we examine the latest progress made in ...
Aquaro Giovanni Donato GD aFondazione Gabriele Monasterio Regione Toscana/CNR, Pisa bUniversity of Florence, Florence cDepartment of Medicine and Pharmacology, University of Messina, Messina, - - 2014
Isolated left ventricular diverticulum, a rare cardiac malformation, can be asymptomatic or associated with systemic embolization, ventricular arrhythmias, or sudden death. MRI allows for the detection of diverticuli and the distinction between fibrous and muscular types using the delayed enhancement technique. To evaluate the prevalence of left ventricular diverticuli in ...
Wahlquist Christine C 1] Department of Bioengineering, University of California, San Diego, and the Muscle Development and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA - - 2014
Heart failure is characterized by a debilitating decline in cardiac function, and recent clinical trial results indicate that improving the contractility of heart muscle cells by boosting intracellular calcium handling might be an effective therapy. MicroRNAs (miRNAs) are dysregulated in heart failure but whether they control contractility or constitute therapeutic ...
Schwartz Peter J PJ Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Casa di Cura San Carlo, Via Pier Lombardo 22, 20135 Milan, - - 2014
Experimental and clinical evidence indicating an antiarrhythmic effect of cardiac sympathetic denervation has been available for 100 years. Experimental data show that left cardiac sympathetic denervation (LCSD), in particular, is not only antiarrhythmic, but also antifibrillatory-an effect exquisitely important for any clinical condition associated with a high risk of ventricular ...
Takeuchi Daiji D Department of Pediatric Cardiology, The Heart Institute, Tokyo Women's Medical University, Tokyo, - - 2014
Although Fontan conversion combined with cardiac resynchronization therapy appears to be an effective surgical solution for the management of failing Fontan circulation with refractory atrial arrhythmia and cardiac dysfunction due to dyssynchronous ventricular wall motion, limited data are available on the mid- to long-term results of this treatment. We report ...
Almendral Jesús J Unidad de Arritmias, Centro Integral de Enfermedades Cardiovasculares, Grupo HM Hospitales, Universidad CEU San Pablo, Madrid, España. Electronic address: - - 2014
This report discusses a selection of the most relevant articles on cardiac arrhythmias and pacing published in 2013. The first section discusses arrhythmias, classified as regular paroxysmal supraventricular tachyarrhythmias, atrial fibrillation, and ventricular arrhythmias, together with their treatment by means of an implantable cardioverter defibrillator. The next section reviews cardiac ...
Pei Zhiqiang Z Intervention Division, Taiyuan City Centre Hospital, Taiyuan 030001, China. Electronic address: - - 2014
Catestatin (CST) displays potent vasodilatory effect and acts on lowering blood pressure in vivo. The clinical utility of CST in patients with acute myocardial infarction (AMI) has not been clearly delineated. The aim of this study was to investigate the predictive value of CST for the development of in-hospital malignant ...
Marunouchi Tetsuro T Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, - - 2014
The mechanisms underlying mitochondrial impairment in the failing heart are not yet clear. In a previous study, we found that the levels of small heat shock proteins (HSP) such as mitochondrial HSPB1 and HSPB8 in the failing heart following myocardial infarction were decreased. In the present study, to verify the ...
Schuetze Katherine B KB Department of Medicine, Division of Cardiology, University of Colorado Denver, 12700 E. 19th Ave., Aurora, Colorado - - 2014
Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias. However the specific cells and signaling pathways mediating this process are poorly understood. Lysine acetylation of nucleosomal histone tails is an important mechanism for the regulation of gene expression. Additionally, proteomic studies ...
Yu Yang Y Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong Province, People's Republic of - - 2014
Cardiac fibrosis is involved in a lot of cardiovascular pathological processes. Cardiac fibrosis can block conduction, cause hypoxia, strengthen myocardial stiffness, create electrical heterogeneity, and hamper systolic ejection, which is associated with the development of arrhythmia, heart failure and sudden cardiac death. Besides the initial stimulating factors, the cardiac fibroblasts ...
Sung Kuo-Tzu - - 2014
Solitary papillary muscle (PM) hypertrophy is an unique type of hypertrophic cardiomyopathy (HCM), which is characterized by predominant papillary muscle hypertrophy sparing the rest of other left ventricular segments. It has recently drawn our attention about the mechanism of left ventricular mid-cavity obstruction and the influence of pressure gradient in ...
Paul David S DS Department of Nutrition, University of NC at Chapel Hill, 27599, USA. Electronic address: - - 2014
In mice with temporally-induced cardiac-specific deficiency of acyl-CoA synthetase-1 (Acsl1(H-/-)), the heart is unable to oxidize long-chain fatty acids and relies primarily on glucose for energy. These metabolic changes result in the development of both a spontaneous cardiac hypertrophy and increased phosphorylated S6 kinase (S6K), a substrate of the mechanistic ...
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