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Herrmann Cheryl C Cheryl Herrmann is Cardiac Clinical Nurse Specialist, Unity-Point Health-Methodist, 221 NE Glen Oak Ave, Peoria, IL 61636 - - 2014
Cardiac arrest in the immediate postoperative recovery period in a patient who underwent cardiac surgery is typically related to reversible causes-tamponade, bleeding, ventricular arrhythmias, or heart blocks associated with conduction problems. When treated promptly, 17% to 79% of patients who experience cardiac arrest after cardiac surgery survive to discharge. The ...
Hool Livia C LC The University of Western Australia, M311 Anatomy, Physiology and Human Biology, 35 Stirling Highway, Crawley, Perth, Western Australia, Australia, 6009, 61864883307, 61864881025 ; - - 2014
Significance: Oxygen occupies a key role in cellular metabolism and function. Oxygen delivery to cells is crucial and a lack of oxygen such as occurs during myocardial infarction can be lethal. Cells must therefore be able to respond to changes in oxygen tension. Recent advances: Since the first studies examining ...
Aliberti Stefano S aDepartment of Health Science, University of Milan-Bicocca, Respiratory Dept, AO San Gerardo, Monza, Italy bChief, Division of Infectious Diseases and Professor of Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky, - - 2014
The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patients with pneumonia based on plaque-related events, such as acute ...
Hartman Matthew E ME *Division of Cardiology, Department of Medicine, and †Department of Pathology, Institute for Stem Cells and Regenerative Medicine, University of Washington, Seattle, Washington, USA; - - 2014
CHF1/Hey2 is a Notch-responsive basic helix-loop-helix transcription factor involved in cardiac development. Common variants in Hey2 are associated with Brugada syndrome. We hypothesized that absence of CHF1/Hey2 would result in abnormal cellular electrical activity, altered cardiac conduction system (CCS) development, and increased arrhythmogenesis. We isolated neonatal CHF/Hey2-knockout (KO) cardiac myocytes ...
Yang Hao H Department of Cardiology, Nanfang Hospital, Southern Medical University,Guangzhou 510515, - - 2014
PATIENTS with chronic heart failure (CHF) have a high incidence of atrial/ventricular arrhythmias which seriously affect life span and quality of life. Cardiac re-synchronization therapy (CRT) can improve cardiac function and reverse myocardial remodeling, therefore improving the quality of life and reducing mortality. CRT with Home-Monitoring (HM) can be used ...
Goldenberg Ilan I The authors' affiliations are listed in the - - 2014
Background The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with an electrocardiographic pattern showing left bundle-branch block was associated with a significant reduction in heart-failure events over a median follow-up of 2.4 years, as ...
Abd El Rahman Mohamed Y MY Department of Pediatric Cardiology, Saarland University Hospital, Kirrberger Straße, 66421, Homburg/Saar, - - 2014
The effect of bosentan on the ventricular and atrial performance in patients with Eisenmenger syndrome is unclear. In adult patients with Eisenmenger syndrome, we aimed to evaluate the midterm effect of bosentan on physical exercise, ventricular and atrial function, and pulmonary hemodynamics. Forty adult patients before and after 24 weeks bosentan ...
Goldberger Jeffrey J JJ From the Center for Cardiovascular Innovation and the Division of Cardiology, Feinberg School of Medicine, Northwestern University, - - 2014
Cardiac-resynchronization therapy (CRT), also known as biventricular pacing, has emerged as a pivotal therapy in selected patients with heart failure with reduced ejection fraction. The mechanism of benefit of CRT is complex and not yet completely understood, but it is probably multifactorial, with effects on contractile function, β-adrenergic responsiveness, and ...
Verschure Derk O DO Department of Nuclear Medicine, Room F2-238, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The - - 2014
The purpose of this study was to determine the most appropriate prognostic endpoint for myocardial (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with chronic heart failure (CHF) based on aggregate results from multiple studies published in the past decade. Original individual late (3-5 h) heart/mediastinum (H/M) ratio data of 636 CHF patients ...
Sommer Anders A Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, Aarhus N DK-8200, - - 2014
Fluoroscopy is the routine method for localizing left ventricular (LV) and right ventricular (RV) lead positions in cardiac resynchronization therapy (CRT). However, the ability of fluoroscopy to determine lead positions in a standard ventricular segmentation is unknown. We aimed to evaluate the accuracy and reproducibility of fluoroscopy to determine LV ...
Florian Anca A Department of Cardiology and Angiology, University Hospital Münster, Albert-Schweitzer-Campus 1, building A1, 48149 Münster, - - 2014
Cardiac involvement with progressive myocardial fibrosis leading to dilated cardiomyopathy is a major cause of death in muscular dystrophy patients. Extracellular volume fraction (ECV) measurement based on T1-mapping pre- and post-contrast promises the detection of early 'diffuse' myocardial fibrosis that cannot be depicted by conventional contrast-imaging based on late gadolinium ...
Cai Jindan J Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, - - 2014
Evaluation of cardiac reserve under myocardial infarction in patients is important for prognosis. However, this evaluation is difficult to be done due to high risk for mortality in patients with severe myocardial infarction. The present study was undertaken using non-human primate model as a substitute for humans to investigate the ...
Lenneman Carrie Geisberg CG Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA, - - 2014
The National Cancer Institute estimates that approximately 13.7 million Americans with a history of cancer were alive on January 1, 2012. With the rising number of cancer survivors, there is an increased focus on how chemotherapy agents modulate the cardiovascular biology and cause chemotherapy-related heart failure in certain patients. Neuregulin-1 ...
Chen Bing-Wei BW Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Beijing, 100037, People's Republic of - - 2014
Cardiac pacing can be used to treat carotid sinus syndrome (CSS), but clinical studies have shown conflicting results. We conducted a systematic review and meta-analysis to evaluate the role of pacing for CSS. A systematic search of publications in PubMed, Embase, and the Cochrane Library without language restriction was performed. ...
Alpert Martin A MA University-Columbia Division of Cardiovascular Medicine, University of Missouri Health Sciences Center, Room CE-306, 5 Hospital Drive, Columbia, MO, 65212, USA, - - 2014
Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well ...
Houmsse Mahmoud M The Ohio State University Wexner Medical Center - Cardiovascular Medicine, Heart and Lung Research Institute, 473 W. 12th Avenue Second floor, Columbus, OH 43235, - - 2014
Cardiac resynchronization therapy (CRT) is a well-established therapy to reduce morbidity and mortality in patients with moderate and severe symptomatic congestive heart failure. Left ventricular (LV) pacing that fuses with intrinsic right ventricular (RV) conduction results in similar or even better cardiac performance compared to biventricular (Biv) pacing. Optimal programming ...
Radovanovic Slavica S Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrado, - - 2014
Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling ...
Weymann Alexander - - 2014
The purpose of this prospective study was to evaluate the effects and functional outcome of central extracorporeal life support (ECLS) with left ventricular decompression for the treatment of refractory cardiogenic shock and lung failure. Between August 2010 and August 2013, 12 consecutive patients (2 female) with a mean age of ...
Lip Gregory Yh GY University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham, UK, B18 - - 2014
Patients with chronic heart failure (heart failure) are at risk of thromboembolic events, including stroke, pulmonary embolism and peripheral arterial embolism, whilst coronary ischaemic events also contribute to the progression of heart failure. Long-term oral anticoagulation is established in certain patient groups, including patients with heart failure and atrial fibrillation, ...
Luo Yaping Y From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of - - 2014
Two adult male patients with myocardial infarction underwent Ga-BNOTA-PRGD2 (arginine-glycine-aspartic acid [RGD]) PET/CT scans. The initial images that were acquired within 1 week after the cardiac event showed RGD retention in the infarcted regions in both patients. At follow-up Ga-BNOTA-PRGD2 PET/CT scans, RGD uptake was again noticed in the infracted ...
Zakharova Liudmila L Center for Cardiovascular Research, Banner Sun Health Research Institute, Sun City, - - 2014
Progenitor cells isolated from cardiac explant-derived cells improve cardiac function after myocardial infarction (MI). To fully realize the therapeutic potential of these cells, it is essential to develop a safe and efficient delivery method. Therefore, the objective of this study was to determine the efficacy of our newly developed approach ...
Singh Sarguni S Department of Internal Medicine, University of Wisconsin School of Medicine and Public Health, Madison, - - 2014
Congestive heart failure (CHF) is an important source of morbidity and mortality in end-stage renal disease patients. Although CHF is commonly associated with low cardiac output (CO), it may also occur in high CO states. Multiple conditions are associated with increased CO including congenital or acquired arteriovenous fistulae or arteriovenous ...
Guiraudon Gerard M GM Canadian Surgical Technologies and Advance Robotics, Lawson Health Research Institute, London Health Science Center, London, Ontario, Canada, - - 2014
This discussion paper re-examines the conduction-activation of the atria, based on observations, with respect to the complexity of the heart as an organ with a brain, and its evolution from a peristaltic tube. The atria do not require a specialized conduction system because they use the subendocardial layer to produce ...
Pietrzyk Edward - - 2014
Extending the length of human life leads to an increase in the elderly population with coronary artery disease. The advanced age does not constitute a contraindication for surgical revascularization. However, according to the available risk scales, the mortality risk associated with performing surgery on patients in the 9th decade of ...
Jędrzejczyk-Patej Ewa E Department of Cardiology, Congenital Heart Disease and Electrotherapy, Silesian Medical University, Silesian Centre for Heart Diseases, Zabrze,. - - 2014
The aim of this study was to evaluate the value of device-based diagnostic parameters in predicting ventricular arrhythmias in cardiac resynchronisation therapy (CRT) recipients. Ninety-six CRT-D patients participating in TRUST CRT Trial were analysed. Inclusion criteria were heart failure in NYHA≥3 class, QRS≥120msec, left ventricular ejection fraction (LVEF)≤35% and significant ...
Cove-Smith Laura L Clinical & Experimental Pharmacology, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, - - 2014
Many efficacious cancer treatments cause significant cardiac morbidity, yet biomarkers or functional indices of early damage, which would allow monitoring and intervention, are lacking. In this study we have utilised a rat model of progressive doxorubicin-induced cardiomyopathy, applying multiple approaches, including cardiac MRI, to provide the most comprehensive characterisation to ...
Fishbein Daniel P DP Seattle Institute for Cardiac Research, Seattle, WA. Electronic address: - - 2014
To determine if six-minute walk assists in treatment decisions for patients with heart failure. In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), prespecified subgroup analysis showed that patients with NYHA Class III symptoms did not benefit from ICD therapy and appeared to be harmed by amiodarone, while NYHA ...
Lin Eric E Simon Fraser - - 2014
The zebrafish (ZF) has emerged as an important model for developmental cardiovascular (CV) biology, however, much less is known about the cardiac function of the adult zebrafish that can be used as a model of teleost CV biology. Here, we describe electrophysiological parameters, such as HR, AP duration (APD) and ...
Kuklik P P Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, - - 2014
The left atrium (LA) plays an important role in the maintenance of hemodynamic and electrical stability of the heart. One of the conditions altering the atrial mechanical function is atrial fibrillation (AF), leading to an increased thromboembolic risk due to impaired mechanical function. Preserving the regions of the LA that ...
Nordberg Per - - 2014
Abstract Background. Cardiac arrest as a consequence of deep accidental hypothermia is associated with high mortality. Standardized prehospital management as well as rewarming with extracorporeal circulation (ECC) are important factors to improve survival. The objective of this case report is to illustrate the importance of effective cardiopulmonary resuscitation (CPR) and ...
Dal-Medico S E SE Universidade Federal de São Carlos, Departamento de Biologia, Rodovia João Leme dos Santos (SP-264), Km 110, 18052-780 Sorocaba, SP, - - 2014
A drastic amphibian decline has been observed worldwide, which can be attributed (among other factors) to exposure to pollutants. Considering that cadmium corresponds to the most rapidly increasing trace metal in the environment, the aim of this work was to evaluate whether the exposure (2 and 16 days) of bullfrog ...
Thomas Penny S PS Department of Biologic and Materials Sciences, University of Michigan -Ann Arbor, 1011 N. University Ave, Ann Arbor, MI-48109, - - 2014
BMP signaling plays an essential role in second heart field-derived heart and arterial trunk development, including myocardial differentiation, right ventricular growth, and interventricular, outflow tract and aortico-pulmonary septation. It is mediated by a number of different BMP ligands, and receptors, many of which are present simultaneously. The mechanisms by which ...
Zapp Eduardo E Laboratory of Biosensors, Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil. Electronic address: - - 2014
A label-free electrochemical immunosensor based on the ionic liquid crystal (E)-1-decyl-4-[(4-decyloxyphenyl)diazenyl]pyridinium bromide (Br-Py) coated on a glassy carbon electrode (GCE) for the quantitative detection of myoglobin (Mb), a cardiac marker for acute myocardial infarction, is reported herein for the first time. The monoclonal anti-myoglobin antibody (ab-Mb) was covalently immobilized using ...
Nakajima Kenichi K Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan, - - 2014
Prediction of mortality risk is important in the management of chronic heart failure (CHF). The aim of this study was to create a prediction model for 5-year cardiac death including assessment of cardiac sympathetic innervation using data from a multicenter cohort study in Japan. The original pooled database consisted of ...
Rodríguez Muñoz Daniel D Department of Cardiology, Ramón y Cajal University Hospital, Madrid, - - 2014
Swirling flow, organized in vortices, contributes to adequate left ventricular function. In this study, we apply a novel echocardiographic flow-mapping technique, vector flow mapping (VFM), to evaluate the main characteristics of left ventricular vortices and its relation to filling parameters. Forty-eight subjects underwent conventional transthoracic echocardiographic examination with additional intracardiac ...
Ermacora Davide D Department of Cardiac, Vascular and Thoracic Sciences, University of Padua, Padua, - - 2014
Three-dimensional echocardiography (3DE) is a unique cardiovascular imaging modality in terms of: ability to provide realistic anatomical views of cardiac structures in the beating heart and possibility to visualize cardiac structures from any desired perspective. Therefore, 3DE is emerging as an accurate imaging modality for a prompt diagnosis and detailed ...
Frangogiannis Nikolaos G NG The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer G46B, Bronx, NY 10461, - - 2014
Myocardial infarction triggers an intense inflammatory response that is essential for cardiac repair, but which is also implicated in the pathogenesis of postinfarction remodelling and heart failure. Signals in the infarcted myocardium activate toll-like receptor signalling, while complement activation and generation of reactive oxygen species induce cytokine and chemokine upregulation. ...
Nalos Marek - - 2014
Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end organ dysfunction. Treatment often includes a combination of diuretics, oxygen, positive pressure ventilation, inotropes and vasodilators or vasopressors. Lactate is a marker of illness severity but is also an important metabolic substrate ...
Langrish Jeremy P JP University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United - - 2014
Epidemiological studies have demonstrated that air pollution exposure is associated with increases in cardiovascular morbidity and mortality. Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups. To investigate the incidence of cardiac ...
Guerrero Orriach Jose L - - 2014
Preoperative use of levosimendan in cardiac surgery patients is one of the most attractive therapeutic alternatives in subjects with left or right ventricular dysfunction. Our review explores the pharmacological bases and clinical evidence for the use of levosimendan, with the intention of making a series of recommendations regarding its use ...
Thireau Jérôme J Inserm U1046, Physiologie & Médecine Expérimentale, Cœur et Muscles, Université Montpellier-1 & 2, , Montpellier, - - 2014
Clinical studies failed to prove convincingly efficiency of intravenous infusion of neseritide during heart failure and evidence suggested a pro-adrenergic action of B-type natriuretic peptide (BNP). However, subcutaneous BNP therapy was recently proposed in heart failure, thus raising new perspectives over what was considered as a promising treatment. We tested ...
Borisenko Oleg O Synergus AB, Danderyd, - - 2014
The objective of the study was to assess the cost of using different blood pumps for short-term ventricular assist device (VAD) and extracorporeal life support (ECLS) systems for cardiac and cardiorespiratory failure in the UK. The cost analysis presented was based on evaluation of the time required to provide circulatory ...
Motoki Hirohiko H Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
Right ventricular (RV) global longitudinal strain (RV strain) is a sensitive measure of RV mechanics. Its relationship with standard clinical markers and long-term events in chronic systolic heart failure is not well established. The aim of this study was to examine the ability of RV strain to provide incremental prognostic ...
Kumar Arun - - 2014
After a cardiac event, proper treatment and care of the damaged tissue is crucial in restoring optimal cardiac function and preventing future cardiac events. Recently, thymosin beta4 has been found to play a vital role in cardiac cell health and development by regulating angiogenesis, inflammatory responses, and wound healing. We ...
Wickham Abeni M AM Integrative Regenerative Medicine (IGEN) Centre and Department of Physics, Chemistry and Biology, Linköping University, Linköping, - - 2014
The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent ...
Kumarswamy Regalla R IMTTS, Hannover Medical - - 2014
Long non-coding RNAs (lncRNAs) represent a novel class of molecules regulating gene expression. LncRNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. Role of lncRNAs as potential biomarkers in heart disease. Global transcriptomic analyses were done in plasma RNA from patients with/without ...
Holloway Cameron J CJ 1 Department of Physiology, Anatomy and Genetics, University of Oxford , United Kingdom - - 2014
Abstract Holloway, Cameron J., Andrew J. Murray, Kay Mitchell, Daniel S. Martin, Andrew W. Johnson, Lowri E. Cochlin, Ion Codreanu, Sundeep Dhillon, George W. Rodway, Tom Ashmore, Denny Z.H. Levett, Stefan Neubauer, Hugh E. Montgomery, Michael P.W. Grocott, and Kieran Clarke, on behalf of the Caudwell Xtreme Everest 2009 Investigators. ...
Yoshihisa Akiomi A Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan; Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan. Electronic address: - - 2014
Chronic obstructive pulmonary disease (COPD) often coexists with heart failure (HF), and is considered to be associated with adverse outcomes in HF patients. However, the features of cardiovascular function and the detailed all-cause mortality of HF with COPD remain unclear. Consecutive 378 patients admitted for HF who underwent spirometry were ...
Marui Akira A Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Ischaemic heart disease is a major risk factor for heart failure. However, long-term benefit of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in those patients has not been well elucidated. Of the 15 939 patients undergoing first myocardial revascularization enrolled in the CREDO-Kyoto PCI/CABG Registry Cohort-2, we ...
Kishima Hideyuki H Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan, - - 2014
Some patients experience a left atrial thrombus (LAT) in spite of taking warfarin. We aimed to clarify the characteristics of patients with LAT during warfarin administration and investigated whether the CHADS2 or CHA2DS2-VASc scores are useful predictors of LAT. We studied 230 patients (169 males, age 65 ± 10 years) who underwent transesophageal ...
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