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Vukovic Petar M PM Departments of Cardiac Surgery (Drs. Micovic, Milicic, Stojanovic, and Vukovic) and Cardiology (Drs. Jovovic and Kosevic), Dedinje Cardiovascular Institute, 11040 Belgrade, - - 2014
Cor triatriatum dexter is a rare congenital heart anomaly in which a membrane divides the right atrium into 2 chambers. We report the case of a 43-year-old woman who had cor triatriatum dexter and a large atrial septal defect. During attempted percutaneous closure, the balloon disrupted the membrane and revealed ...
Garcia-Morales Luis J LJ Department of Cardiovascular Surgery, Methodist DeBakey Heart & Vascular Center, Houston, Texas - - 2014
Bleeding can occur as a sequela to cardiac surgery. Surgical products-such as conventional sutures and clips, and somewhat less conventional sealants-have been developed to prevent this event. Among these, CoSeal is a sealant used at our institution; here we report the cases of 2 patients in whom CoSeal was used ...
Pisani Paolo P Department of Cardiovascular Surgery (Drs. Fabbrocini, Medici, Pisani, and Sandrelli), NCC Città di Alessandria Hospital, 15121 Alessandria; and Department of Cardiovascular Surgery (Dr. Tesler), Policlinico di Monza, Clinica San Gaudenzio, 28100 Novara; - - 2014
Percutaneous closure of the left atrial appendage (LAA) is a new approach to the prevention of cardioembolic events in patients with atrial fibrillation. We implanted an LAA occlusion device (Amplatzer™ Cardiac Plug) in a 70-year-old woman via a transseptal approach. Upon her discharge from the hospital, a transthoracic echocardiogram showed ...
Segura Ana Maria AM Departments of Cardiovascular Pathology (Drs. Buja, Clubb, and Segura) and Cardiopulmonary Transplantation (Drs. Frazier, Massin, and Taegtmeyer), Texas Heart Institute; and Departments of Internal Medicine (Drs. Dris and Taegtmeyer) and Pathology and Laboratory Medicine (Dr. Buja), The University of Texas Medical School at Houston; Houston, Texas - - 2014
Mechanical cardiac unloading with use of a left ventricular assist device (LVAD) is associated with substantial improvements in left ventricular function and enables subsequent LVAD explantation in some patients. We describe the case of a 35-year-old man with dilated nonischemic cardiomyopathy who was supported with an LVAD for 9 months. ...
Desbène Cédric C Laboratoire de biochimie, Pôle de biologie pathologie, Centre hospitalier Le Mans, - - 2014
This paper points out the structural and physiological data of galectin-3, and emphasizes its role in cardiac fibrosis and heart failure pathophysiology. Then we summarize the optimal conditions for sampling, assays and we discuss the interpretation of results.
Wang Qingsheng Q Department of Cardiology, Qinhuangdao First Hospital, Hebei Medical University, Hebei, China. E-mail. - - 2014
To evaluate the long-term results in elderly patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents for unprotected left main coronary artery disease by transradial approach. This study took place in Qinhuangdao First Hospital, Hebei Medical University, Hebei, China between October 2006 and December 2009. Seventy-nine elderly patients with unprotected ...
Gallet Romain R AP-HP - University Hospital Henri Mondor, Cardiovascular Department, INSERM U955 Team 3, Creteil, France. Electronic address: - - 2014
Dobutamine induced tachycardia increases myocardial oxygen consumption and impairs ventricular filling. We hypothesized that Ivabradine may be efficient to control dobutamine induced tachycardia. We assessed the effects of Ivabradine in addition to dobutamine in stable heart failure (HF) patients (LVEF<35%, n=22, test population) and validated its effects in refractory cardiogenic ...
Nagarakanti Rangadham R Electrophysiology Research Foundation, 161 Washington Valley Road, Suite 201, Warren, NJ, 07059, - - 2014
Dual-site right atrial pacing (DAP) produces electrical atrial resynchronization but its long-term effect on the atrial mechanical function in patients with refractory atrial fibrillation (AF) has not been studied. Drug-refractory paroxysmal (PAF) and persistent AF (PRAF) patients previously implanted with a dual-site right atrial pacemaker (DAP) with minimal ventricular pacing ...
Buckberg Gerald D GD Department of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA - - 2014
Normal cardiac function of the left and right ventricles, together with the septum, is related to form/function interactions within the helical ventricular myocardial band. This knowledge is a prerequisite to understanding form/function interactions in diseases and for planning new treatments. Topics discussed include congestive heart failure in dilated hearts of ...
Mantegazza Valentina V aCentro Cardiologico Monzino, IRCCS, Milano bPulmonary Hypertension Unit, Department of Cardiovascular and Respiratory Disease, "Sapienza" University of Rome, Roma cSpedali Civili Hospital of Brescia, Universityof Brescia, Brescia dDepartment of Health Science, University of Milano Bicocca & Department of Cardiology, S. Luca Hospital, IstitutoAuxologicoItaliano eSleep Disorders Center, Department of Cardiology, S. Luca Hospital, IstitutoAuxologicoItaliano, Milano fDepartment of Medical Sciences and Translational Medicine, "Sapienza" University of Rome, Sant'Andrea Hospital, Roma gDivision of Cardiology, University of Perugia, Perugia hCardiac Thoracic and Vascular Department, University of Pisa, Pisa iDepartment of Cardiology, University of Foggia, "OspedaliRiuniti" OO. RR, Foggia jDepartment of Clinical and Molecular Medicine, "Sapienza" University of Rome, Roma kDepartment of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milano, - - 2014
Heart failure is a widespread syndrome involving several organs, still characterized by high mortality and morbidity, and whose clinical course is heterogeneous and hardly predictable.In this scenario, the assessment of heart failure prognosis represents a fundamental step in clinical practice. A single parameter is always unable to provide a very ...
Li Jin J Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada; Department of Cardiology, University of Heidelberg, Heidelberg, - - 2014
Autoantibodies directed against various cardiac receptors have been implicated in cardiomyopathy and heart-rhythm disturbances. In a previous study among patients with dilated cardiomyopathy, autoantibodies targeting the cardiac voltage-gated KCNQ1 K(+)-channel were associated with shortened QTc-intervals. However, the electrophysiological actions of KCNQ1 autoimmunity have not been assessed experimentally in a direct ...
Gage Ryan M RM Research Division, United Heart & Vascular Clinic, 225 N. Smith Avenue, #400, St Paul, MN, - - 2014
Right ventricular pacing (RVp) results in an electrocardiographic left bundle branch block pattern and can lead to heart failure. This study aimed to evaluate echocardiographic and clinical outcomes of heart failure patients with RVp upgraded to cardiac resynchronization therapy (CRT), as they are frequently excluded from multicentre studies. This observational ...
Wang Yabin Y 1 Department of Cardiology, PLA General Hospital , Beijing, China - - 2014
Abstract Aims: Clinical application of cellular therapy for cardiac regeneration is significantly hampered by the low retention of engrafted cells, mainly attributable to the poor microenvironment dominated by inflammation and oxidative stress in the host's infarcted myocardium. This study aims at investigating whether liver X receptor (LXR) agonist T0901317 will ...
Chen Zhang-Wei ZW Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, - - 2014
This experimental study was designed to clarify the relationship between cardiomyocyte apoptosis and tumour necrosis factor-alpha (TNF-α) expression, and confirm the effect of TNF-α on cardiac dysfunction after coronary microembolization (CME) in mini-pigs. Nineteen mini-pigs were divided into three groups: sham-operation group (n = 5), CME group (n = 7) ...
McNeice Andrew H AH Craigavon Cardiac Centre, Southern Trust, Northern Ireland, BT63 5QQ, - - 2014
Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugrel, sodium nitrite, inclacumab, ranolazine, preventive coronary intervention of non-culprit ...
Ewy Gordon A GA Department of Medicine, University of Arizona Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, USA - - 2014
Out-of-hospital cardiac arrest (OHCA) is a major public health problem. In the United States, OHCA accounts for more premature deaths than any other cause. For over a half-century, the national "Guidelines" for resuscitation have recommended the same initial treatment of primary and secondary cardiac arrests. Using this approach, the overall ...
Shen Cheng C Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, - - 2014
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) was demonstrated to play cardioprotective roles in cardiovascular diseases. Nonetheless, little is known about the roles and mechanisms of ALDH2 in pressure overload-induced cardiac damages. In this study, we revealed that ALDH2 deficiency overtly exacerbated transverse aortic constriction (TAC)-induced cardiac dysfunction. Cardiomyocyte enlargement was observed ...
Abdurrachim Desiree D Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612AZ Eindhoven, The - - 2014
Obesity is often associated with abnormalities in cardiac morphology and function. This study tested the hypothesis that obesity-related cardiomyopathy is caused by impaired cardiac energetics. In a mouse model of high-fat diet (HFD)-induced obesity, we applied in vivo cardiac (31)P magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) to ...
Kim Won-Keun WK Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany; Department of Cardiac Surgery, Kerckhoff Heart Center, Bad Nauheim, - - 2014
Myocardial injury after transcatheter aortic valve replacement (TAVR) is common, but its cause and relationship to the extent of myocardial tissue loss remain unclear. This study sought to examine the incidence and degree of ischemic myocardial damage using cardiac magnetic resonance imaging and myocardial biomarkers in patients undergoing TAVR. Patients ...
Syed Faisal F FF Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, - - 2014
Constrictive pericarditis can result from a stiff pericardium that prevents satisfactory diastolic filling. The distinction between constrictive pericarditis and other causes of heart failure, such as restrictive cardiomyopathy, is important because pericardiectomy can cure constrictive pericarditis. Diagnosis of constrictive pericarditis is based on characteristic haemodynamic and anatomical features determined using ...
Estes N A Mark NA 3rd Tufts University School of Medicine, Boston, MA - - 2014
Sudden cardiac death (SCD) from cardiac arrest remains the leading cause of cardiovascular mortality worldwide and accounts for approximately 250,000 deaths annually in the United States.(1-4) The majority of cardiac arrests occur in patients with a prior myocardial infarction at a rate approximately five times that of the general population.(3) ...
Hole Lisa Drange - - 2014
Elevated cardiac troponin levels are consistent with the diagnosis of an acute coronary syndrome, but may also represent adverse drug reactions. Psychostimulating drugs raise both blood pressure and heart rate, and case reports of sudden death, stroke, and myocardial infarction have led to regulatory and public concern about the cardiovascular ...
Selan Jeffrey C JC Department of Medicine, Tufts Medical Center, Boston, MA. Electronic address: - - 2014
Cardiac sarcoidosis (CS) affects less than 5% of patients with pulmonary or systemic sarcoidosis, but when present is often associated with a spectrum of clinically significant conduction abnormalities and arrhythmias. The cardinal manifestations of CS include conduction disturbances, arrhythmias, or congestive heart failure. Less commonly, there is concealed subclinical disease. ...
Böning Andreas A Department of Cardiovascular Surgery, Justus-Liebig University Giessen, Giessen, - - 2014
Background Controversy exists as to whether warm or cold Calafiore blood cardioplegia (BCP) is better for cardiac preservation. Therefore, we compared hemodynamic performance, myocardial metabolism, and ultrastructural preservation in rat hearts after application of cold or warm BCP. Materials and Methods The hearts of 24 male Wistar rats were excised and inserted ...
Wu Bo-Wei BW 1Department of Physiology, Shanxi Medical University, Taiyuan, China. 2Department of Physiology, Institute of Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, - - 2014
: Zacopride, an IK1 agonist with moderate potency, could exert significant antiarrhythmic and cardiac protective effects. To date, there is no report to show that zacopride is proarrhythmic in both experimental studies and clinical trials. However, in certain cardiac pathological conditions, especially short QT syndrome and certain reentry tachycardia, zacopride ...
Mulpuru Siva K SK Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
Right ventricular outflow tract (RVOT) arrhythmias are a common form of ventricular tachycardia (VT) in patients with structurally normal heart. The underlying mechanism is due to triggered activity. Mapping and ablation is relatively straightforward targeting the earliest point of activation. Previously reported causes of difficult ablation in the RVOT region ...
Butera Gianfranco G 1Department of Pediatric and Adult Congenital Heart Disease,Policlinico San Donato IRCCS,San Donato - - 2014
Cardiac catheterisation in congenital heart disease is a developing field. Patients' ages range from foetus to adulthood. This document is a revision and update of the previously published recommendations and summarises the requirements for training in diagnostic and interventional cardiac catheterisation.
Chan Pak-Hei PH Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong, SAR, China; Department of Medicine, Hong Kong University-Shenzhen Hospital, - - 2014
Despite successful surgical therapy, significant proportions of patients with valvular heart diseases have persistent left ventricular dysfunction and develop progressive systolic heart failure. This article is protected by copyright. All rights reserved.
Reis Lewis A LA Institute of Biomaterials and Biomedical Engineering, University of Toronto, ON, - - 2014
Cardiovascular disease is the leading cause of death in the developed world, and as such there is a pressing need for treatment options. Cardiac tissue engineering emerged from the need to develop alternative sources and methods of replacing tissue damaged by cardiovascular diseases, as the ultimate treatment option for many ...
Carrigan Thomas T Division of Cardiovascular Medicine and Department of Radiology, University of Michigan, Ann Arbor, Michigan, - - 2014
Epicardial left ventricular idiopathic ventricular arrhythmias (VAs) can be approached via the pericardial space, the coronary venous system (CVS), or other surrounding structures. The anatomic relationships between epicardial sites of origin (SOO) of VAs and surrounding anatomic structures have not been systematically described. In 17 patients with idiopathic epicardial VAs, ...
Peters Ferande F Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South - - 2014
We prospectively evaluated long-term clinical outcomes of patients diagnosed with isolated left ventricular noncompaction (ILVNC) and heart failure from a sub-Saharan African population. Patients in this single-center study were followed at a tertiary care institution. Clinical follow-up was performed with protocol-driven echocardiographic screening for ventricular thrombus every 4 months. Warfarin ...
Mlynarski Rafal R Rafal Mlynarski, Agnieszka Mlynarska, Maciej Sosnowski, Unit of Noninvasive Cardiovascular Diagnostics, Medical University of Silesia, Upper-Silesian Cardiology Center, Katowice 40-635, - - 2014
The role of the coronary venous system was underestimated for many years. In the last 20 years, a few percutaneous cardiology techniques in which the anatomy of the coronary venous system was significant were developed and are in use. The most important seems to be cardiac resynchronization therapy, which is ...
Galetta Fabio F Department of Clinical and Experimental Medicine, University of Pisa, - - 2014
Myocardial involvement has not been extensively investigated in mitochondrial myopathies. The aim of the study was to assess the myocardial morpho-functional changes in patients with chronic progressive external ophthalmoplegia (PEO). Twenty patients with PEO and 20 controls underwent standard echocardiography with tissue Doppler imaging (TDI) and integrated backscatter (IBS) analyses. ...
Nakahara Shiro S Department of Cardiology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan, - - 2014
The left atrial appendage (LAA) is a possible key contributor to the maintenance of persistent atrial fibrillation (PsAF). The effect of LAA ostial ablation on global left atrial higher-frequency sources remains unclear. Complex fractionated electrograms (CFEs) and dominant frequency (DF) maps acquired with a NavX system in 58 PsAF patients ...
Lang Nora N Department of Pediatric Cardiology and Intensive Care Medicine, Ludwig-Maximilians-University, Munich, Germany Department of Congenital Heart Defects and Pediatric Cardiology, Heart Center, University of Freiburg, Freiburg, Germany nora.lang@universitaets-herzzentrum.de - - 2014
Current materials for closure of cardiac defects such as ventricular septal defects (VSDs) are associated with compliance mismatch and a chronic inflammatory response. Bacterial nanocellulose (BNC) is a non-degradable biomaterial with promising properties such as high mechanical strength, favourable elasticity and a negligible inflammatory reaction. The aim of this study ...
Satoh Hiroshi H Hiroshi Satoh, Makoto Sano, Kenichiro Suwa, Takeji Saitoh, Mamoru Nobuhara, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Hideharu Hayashi, Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu 431-3192, - - 2014
The recent development of cardiac magnetic resonance (CMR) techniques has allowed detailed analyses of cardiac function and tissue characterization with high spatial resolution. We review characteristic CMR features in ischemic and non-ischemic cardiomyopathies (ICM and NICM), especially in terms of the location and distribution of late gadolinium enhancement (LGE). CMR ...
Nishida Junichi J Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-8543, - - 2014
Whether different patterns of ventricular ballooning in takotsubo cardiomyopathy (TCM) reflect differences in trigger mechanisms or clinical outcomes is unclear. Here we examined differences in the clinical characteristics of typical and atypical forms of TCM. TCM patients (n = 251) in the BOREAS Registry were enrolled for comparison of TCM with apical ...
Lewek Joanna J Department of Electrocardiology, Chair of Cardiology and Cardiosurgery, Medical University Lodz, Regional Sterling Heart Disease Center, 91-425 Lodz, Sterling 1/3, - - 2014
Inflammation is a pathological condition known since ancient times. Recent discoveries of inflammatory markers have given new insights into the role of inflammation in the pathogenesis of arrhythmias. This article reviews global data on possible correlations between inflammation - acute or chronic - and cardiac arrhythmias. The authors discuss the ...
Liang Yeyou Y School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of - - 2014
The beneficial effects of mesenchymal stem cells (MSCs) in cardiac cell therapy are greatly limited due to poor survival after transplantation into ischemic hearts. Here, we investigated whether caspase 8 small hairpin RNA (shRNA) modification enhance human MSCs (hMSCs) survival and improve infarcted heart function. Recombinant adenovirus encoding pre-miRNA-155-designed caspase ...
Majidi Mohamed M Duke Clinical Research Institute, Duke University Medical Center, USA Department of Cardiology, Maastricht University Medical Center, The - - 2014
Establishing epicardial flow with percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is necessary but not sufficient to ensure nutritive myocardial reperfusion. We evaluated whether adding myocardial blush grade (MBG) and quantitative reperfusion ventricular arrhythmia "bursts" (VABs) surrogates provide a more informative biosignature of optimal reperfusion in patients ...
See Hoe Louise E - - 2014
Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion channel and receptor function, and protective stress-signaling. However, the importance of membrane cholesterol content to cardiovascular function, and myocardial responses to ischemia-reperfusion (IR) and cardioprotective stimuli are unclear. We assessed effects of graded cholesterol depletion with methyl-β-cyclodextrin (MβCD), and lifelong knockout ...
Niebauer Mark J MJ Cleveland Clinic, Cleveland, OH. Electronic address: - - 2014
Baseline QRS duration (QRSd) ≥150 ms is a recognized predictor of clinical improvement by cardiac resynchronization therapy (CRT), particularly for those with left bundle branch (LBBB). Patients with QRSd <150ms, are considered less likely to respond. We theorized that left ventricular dyssynchrony, while usually associated with wider QRSd, also exhibits ...
Ong Sang-Ging SG The Hatter Cardiovascular Institute, University College London & Medical School, UK Department of Medicine, Division of Cardiology, Stanford University, Stanford, - - 2014
Hypoxia inducible factor-1 (HIF-1) has been reported to promote tolerance against acute myocardial ischemia-reperfusion injury (IRI). However, the mechanism through which HIF-1 stabilization actually confers this cardioprotection is not clear. We investigated whether HIF-1¦Á stabilization protects the heart against acute IRI by preventing the opening of the mitochondrial permeability transition ...
Tan Timothy C TC Department of Cardiology, Massachusetts General Hospital, Harvard Medical - - 2014
Atrial fibrillation is a sustained arrhythmia commonly encountered in clinical practice. It has a high prevalence among the elderly, and contributes significantly to the global social-economic burden. Among many risk factors predisposing to atrial fibrillation is left atrial remodeling and wall fibrosis. Frequently, pathological left atrial wall remodeling and fibrosis ...
Ezekowitz Justin A - - 2014
Nationally, symptomatic heart failure affects 1.5-2% of Canadians, incurs $3 billion in hospital costs annually and the global burden is expected to double in the next 1-2 decades. The current one-year mortality rate after diagnosis of heart failure remains high at >25%. Consequently, new therapeutic strategies need to be developed ...
Puelacher C C Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, Petersgraben 4, 4031, Basel, - - 2014
The acute coronary syndrome (ACS) represents a diagnostic challenge: on the one hand patients need to be quickly identified to initiate treatment and on the other hand early exclusion of patients without ACS is important to relieve patient stress as well as overcrowded emergency departments. A growing number of biomarkers ...
Murín Pavol P Department of Cardiology, Safarik University and East-Slovak Institute of Cardiovascular Diseases, Košice, Slovak - - 2014
Myocardial contractile reserve (CR) is a strong prognostic factor in patients with heart failure. The presence of significant myocardial fibrosis can lead to a reduced response to cardiac resynchronization therapy (CRT). We assumed that myocardial CR assessed by high-dose dobutamine stress echocardiography (DSE) would predict response to CRT. Fifty-two consecutive ...
Kuczmarski James M JM University of - - 2014
The purpose of this investigation was to determine the effect of 4-weeks of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be effective in preserving cardiac function in AI. Male Sprague Dawley rats ...
Lin Chen-Ching CC Biodiversity Research Center, Academia Sinica, Taipei 115, TaiwanDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637, - - 2014
MicroRNAs are a class of endogenous small noncoding RNAs that regulate gene expression either by degrading target mRNAs or by suppressing protein translation. MicroRNAs have been found to be involved in many biological processes, such as development, differentiation and growth. However, the evolution of microRNA regulatory functions and networks has ...
Yu Yang Y Department of Cardiovascular Diseases, First Hospital of Harbin Medical University, Harbin, Heilongjiang, - - 2014
Chronic atrial fibrillation (AF) leads to heterogeneous autonomic nerve innervation termed neural remodeling. The quantitative changes in neural density as a function of autonomic remodeling and its association with sustained AF has not been previously determined. Seven dogs (paced group) were chronically paced with electrodes sutured to the epicardium of ...
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