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Jing Linyuan L Departments of Pediatrics, Physiology, Biomedical Engineering and Medicine, University of Kentucky, UK Chandler Hospital, 741 S Limestone, BBSRB B353, Lexington, KY 40536, - - 2014
Patients with repaired tetralogy of Fallot (rTOF) frequently have right bundle branch block. To better understand the contribution of cardiac dyssynchrony to dysfunction, we developed a method to quantify left (LV), right (RV), and inter-ventricular dyssynchrony using standard cine cardiac magnetic resonance (CMR). Thirty patients with rTOF and 17 healthy ...
Espinoza Andreas W AW The Intervention Centre and Department of Cardiology, Rikhospitalet, Institute for Clinical Medicine, University of Oslo, N-0424, Oslo, - - 2014
The aim of this PhD thesis was to provide a continuous method to monitor myocardial function during cardiac surgery with the superior sensitivity of ultrasonic technique and the continuity of electrocardiographic (ECG) monitoring. An ultrasound system with epicardial transducers was provided, presenting real-time M-mode LV wall images. In two experimental ...
Kim So-Sun SS College of Nursing, Nursing Policy Research Institute, Yonsei University, Seoul, - - 2014
The purpose of this study was to develop a comprehensive cardiac rehabilitation program that considered patients' learning needs and cultural context, and to identify the impact of this program on patients with coronary heart disease in Korea. We employed a quasi-experimental design to evaluate the effects of the developed program ...
Vizzardi Enrico E Section of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, - - 2014
Obstructive sleep apnoea-hypopnoea (OSAH) is a prevalent condition characterized by repetitive pharyngeal collapse during sleep, leading to hypoxemia, hypercapnia, and persistent inspiratory efforts against an occluded airway until arousal. Several studies demonstrated that OSAH exerts acute and chronic effects on the cardiovascular system. Thus, although being a respiratory problem, the ...
Wang Man M Department of Ultrasound in Medicine, Shanghai Sixth People Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, - - 2014
Coronary artery disease is a common cardiovascular disease that often causes myocardial infarction (MI), which, after a certain period, can develop into congestive heart failure, resulting in high mortality and mortality rates. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) has recently been considered a final common effector in myocardial ...
Sousa Pedro Alexandre PA Serviço de Cardiologia, Hospital de Faro, E.P.E., Faro, Portugal. Electronic address: - - 2014
Congenitally corrected transposition of the great arteries is a rare heart defect that can be associated with systemic ventricular dysfunction and conduction disturbances. The use of cardiac resynchronization therapy in patients with congenital heart disease is not fully established. The authors report a case of cardiac resynchronization therapy in a ...
Carrasco-Sánchez Francisco Javier FJ Internal Medicine Department, Complejo Hospitalario de Huelva, Hospital Juan Ramón Jiménez, Ronda Norte s/n 21005, Huelva, Spain, - - 2014
Galectin-3 is a soluble β-galactoside-binding lectin released by activated cardiac macrophages. Elevated levels of galectin-3 have been found to be associated with adverse outcomes in patients with heart failure. A number of recent studies suggest that galectin-3 may provide relevant information regarding the pathophysiologic process of heart failure. We analyzed ...
Coppo Simone S Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, - - 2014
To test the hypothesis that intervals with superior beat-to-beat coronary artery repositioning precision exist in the cardiac cycle, to design a coronary MR angiography (MRA) methodology in response, and to ascertain its performance. Coronary repositioning precision in consecutive heartbeats was measured on x-ray coronary angiograms of 17 patients and periods ...
Torregrosa Isidro I Servicio de Nefrología, Hospital Clínico Universitario de Valencia, Av Blasco Ibáñez 17, 46010, Valencia, Spain, - - 2014
Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early ...
Cowling Randy T RT UCSD - - 2014
The discoidin domain receptor 2 (DDR2) is a fibrillar collagen receptor that is expressed in mesenchymal cells throughout the body. In the heart it is selectively expressed on cardiac fibroblasts. We generated a germline DDR2 knockout mouse and used this mouse to examine the role of DDR2 deletion on heart ...
Sojka Stephen S University of North Carolina McAllister Heart Institute, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, USA Department of Biology, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, - - 2014
The identification and characterization of the cellular and molecular pathways involved in the differentiation and morphogenesis of specific cell types of the developing heart are crucial to understanding the process of cardiac development and the pathology associated with human congenital heart disease. Here, we show that the cardiac transcription factor ...
Paul Arghya - - 2014
The objective of this study was to develop an injectable and biocompatible hydrogel which can efficiently deliver a nanocomplex of graphene oxide (GO) and vascular endothelial growth factor-165 (VEGF) pro-angiogenic gene for myocardial therapy. For the study, an efficient non-viral gene delivery system using polyethylenimine (PEI) functionalized GO nanosheets (fGO) ...
Dorbala Sharmila S Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Departments of Radiology and Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division and Cardiac Amyloidosis Program, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
The purpose of this study was to test the hypothesis that coronary microvascular function is impaired in subjects with cardiac amyloidosis. Effort angina is common in subjects with cardiac amyloidosis, even in the absence of epicardial coronary artery disease (CAD). Thirty-one subjects were prospectively enrolled in this study, including 21 ...
Vilahur Gemma G Cardiovascular Research Center, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, - - 2014
Studies in patients support a beneficial effect of statin treatment early after acute coronary syndrome and/or prior percutaneous coronary intervention. However, statin effect during total occlusion remains unknown. To investigate whether infusion of activated simvastatin during ischemia and prior reperfusion and oral administration thereafter confers cardioprotection and improves cardiac healing ...
Kaschina Elena E Center for Cardiovascular Research, Charité - Medical Faculty Berlin, Hessische Str. 3-4, 10115, Berlin, Germany, - - 2014
The angiotensin AT2-receptor mediates tissue protective actions. Its regenerative potential has been tested in multiple disease models including models of myocardial infarction. These studies used different experimental approaches in order to detect AT2-receptor-related effects such as AT2-receptor deficiency or overexpression, treatment with an AT1-receptor blocker leading to indirect stimulation of ...
Bennett Noel M NM From the *Keck School of Medicine of the University of Southern California; and †Department of Radiology, LAC+USC Medical Center, Los Angeles, - - 2014
Diastolic dysfunction is commonly associated with heart failure with preserved systolic function. Diastolic abnormality includes progressively impaired left ventricle (LV) relaxation, followed by pseudonormal mitral inflow pattern with Valsalva enhancement, and finally restrictive LV filling. Diastolic dysfunction may lead to left atrial dilatation with consequent atrial fibrillation. Gated myocardial perfusion ...
Andersen Mads J MJ The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, - - 2014
Heart failure (HF) is the leading cause of hospitalization among older adults and the prevalence is growing with the aging populations in western countries. Approximately one-half of patients with HF have preserved ejection fraction (HFpEF). In contrast to HF with reduced EF (HFrEF), there is no proven effective treatment for ...
Kolte Dhaval D From the *Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY; †Scottsdale Healthcare, Scottsdale Cardiovascular Center, Scottsdale, AZ; and ‡Department of Medicine & Pharmacology, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, - - 2014
Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular ...
Díaz Olga M Seco OM Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA - - 2014
Objective-To determine prevalence of myocardial injury in horses with colic on the basis of high concentrations of cardiac troponin I (cTnI), frequency of cardiac arrhythmias within the first 24 to 48 hours after hospital admission or surgery because of colic, and associations between high cTnI concentrations and cardiac arrhythmias, clinical ...
García-Prieto Jaime J Imaging, Epidemiology and Atherothrombosis Department, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, - - 2014
Selective stimulation of β3 adrenergic-receptor (β3AR) has been shown to reduce infarct size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term effect and the cardioprotective mechanisms at the level of cardiomyocytes have not been elucidated, and the impact of β3AR stimulation has not been evaluated in a ...
Hong Kyung U KU Institute of Molecular Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY, 40202, USA, - - 2014
The discovery of adult cardiac stem cells (CSCs) and their potential to restore functional cardiac tissue has fueled unprecedented interest in recent years. Indeed, stem-cell-based therapies have the potential to transform the treatment and prognosis of heart failure, for they have the potential to eliminate the underlying cause of the ...
Tadros Rafik R Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Québec, Canada; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Québec, - - 2014
Sex differences in cardiac electrophysiological properties and arrhythmias are evident in epidemiologic and investigative studies as well as in daily patient care. At the supraventricular level, women are at increased risk of sick sinus syndrome and atrioventricular (AV) node re-entrant tachycardia, whereas men manifest more AV block and accessory pathway-mediated ...
Lee Hye Young HY Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ; Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, - - 2014
Recent studies show positive association of early repolarization (ER) with the risk of life-threatening arrhythmias in patients with coronary artery disease (CAD). This study was to investigate the relationships of ER with myocardial scarring and prognosis in patients with CAD. Of 570 consecutive CAD patients, patients with and without ER ...
Duerr Georg D GD Department of Cardiac Surgery, University Clinical Centre Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, - - 2014
Ischemic heart disease is associated with inflammation, interstitial fibrosis and ventricular dysfunction prior to the development of heart failure. Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be involved, but their potential role in cardioprotection is not well understood. We therefore explored the role of the cannabinoid receptor ...
Beake Matthew Jonathan MJ 1Neonatal Unit,Birmingham Women's Hospital NHS Trust,Birmingham,United - - 2014
A preterm 29-week gestation baby was delivered because of gross foetal hydrops secondary to congenital complete heart block. Despite a poor prognosis, she survived stabilisation and received emergency epicardial pacing followed by permanent pacemaker insertion on day 13, weighing 1.2 kg.
Qi Dake - - 2014
The cellular response to stress involves the recruitment and coordination of molecular signaling pathways that prevent cell death. D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic substrates in mammalian cells, but shares partial sequence and structural homology with macrophage migration inhibitory factor (MIF). Here, we observed that DDT is ...
Güder Gülmisal G Comprehensive Heart Failure Center, University of Würzburg, Würzburg, - - 2014
Heart failure and COPD are very common in the elderly. As both syndromes share common risk factors, such as tobacco smoking, and pathophysiological pathways, including systemic inflammation and activation of the neurohumoral system, they frequently coincide. Because of the similar clinical presentation, diagnoses of COPD in the presence of heart ...
Arcaro Alessia A IRCCS Neuromed, Pozzilli, IS, - - 2014
The loss of contractile function is a hallmark of heart failure. Although increasing intracellular Ca(2+) is a possible strategy for improving contraction, current inotropic agents that achieve this by raising intracellular cAMP levels, such as β-agonists and phosphodiesterase inhibitors, are generally deleterious when administered as long-term therapy due to arrhythmia ...
Donaldson Erin E EE Baylor Heart and Vascular Institute (Donaldson, Ko, Roberts) and the Departments of Internal Medicine, Division of Cardiology (Kuiper, Roberts), Pathology (Roberts), and Cardiothoracic Surgery (Chamogeorgakis), Baylor University Medical Center at Dallas. Dr. Donaldson is now with the Department of Family Medicine, Methodist Charlton Medical Center, Dallas, - - 2014
Described herein is a 68-year-old man who underwent cardiac transplantation for severe chronic heart failure resulting from ischemic cardiomyopathy. Examination of the excised heart showed not only extensive left ventricular scarring but also a huge collection of adipose tissue in the subepicardial region and surprisingly also in the ventricular septum. ...
De Viti D D Cardiology Unit, Casa di Cura Santa Maria, Bari, - - 2014
We present a case of large pedunculated myxoma (61×39 mm) in the left ventricular cavity with anterior-septal and anterior free wall akinesia. Angiographic study showed normal coronary arteries, but the clinical signs strongly suggested a previous myocardial infarction. We cannot exclude the possibility that the ventricular akinesia results from embolization ...
Papadaniil Chrysa D - - 2014
An efficient heart sound segmentation (HSS) method that automatically detects the location of first ( S1) and second ( S2) heart sound and extracts them from heart auscultatory raw data is presented here. The heart phonocardiogram is analyzed by employing ensemble empirical mode decomposition (EEMD) combined with kurtosis features to ...
Richards A Mark AM Cardiac Department, Cardiovascular Research Institute, National University Heart Centre, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228, Singapore; Department of Medicine, Christchurch Heart Institute, University of Otago, Christchurch, 2 Riccarton Avenue, Christchurch 8140, New Zealand. Electronic address: - - 2014
Timely diagnosis, early introduction of appropriate treatment, accurate risk stratification, and optimal titration of therapy are all key to the management of acute and chronic heart failure (HF). Plasma concentrations of the cardiac natriuretic peptides (NPs) are valuable aids in each of these elements of care. However, most data are ...
Kovács Arpád A Division of Clinical Physiology, Faculty of Medicine, Institute of Cardiology, University of Debrecen, Móricz Zs. krt. 22, Debrecen 4032, - - 2014
Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent ...
Ki Young-Jae YJ Department of Internal Medicine, Chosun University School of Medicine, Gwangju 501-759, Republic of - - 2014
The aim of this study was to determine the associations of brachial-ankle pulse wave velocity (baPWV), high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the development of adverse outcomes after percutaneous coronary intervention (PCI). The baPWV, hs-cTnT and NT-proBNP were analyzed in 372 patients who ...
Bottio Tomaso T Department of Cardiology and Cardiovascular Surgery, University of Padova Medical School, Padova, Italy - - 2014
Mechanical support by means of ventricular assist devices is at present the most promising alternative of efforts aimed at increasing the supply of donor organs. The support of the left dysfunctional ventricle enables appropriate haemodynamic stabilization and recovery of secondary organ failure, often present in these severely ill patients. The ...
Ng Lauren L Division of Critical Care and Neurotrauma and Cerebrovascular Diseases, Department of Neurology, Thomas Jefferson University, 901 Walnut Street, 4th Floor, Philadelphia, PA 19107, USA; Division of Critical Care and Neurotrauma, Department of Neurological Surgery, Thomas Jefferson University, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, - - 2014
In this review, cardiac arrest is discussed, with a focus on neuroprognostication and the emerging data, with regard to identifying more accurate predictors of neurologic outcomes in the era of therapeutic hypothermia. Topics discussed include recent controversies with regard to targeted temperature management in comatose survivors of cardiac arrest; neurologic ...
Peterss Sven S Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany Department of Cardiac Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, - - 2014
Different revascularization strategies for patients with acute myocardial infarction (AMI) exist. It remains unclear whether ventricular unloading using cardiopulmonary bypass (CPB) or extracorporeal life support (ECLS) has an impact on early postischaemic ventricular function. Here, we report on the results of an approach using a miniaturized CPB in a well-established ...
Hunter Christopher L CL Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, - - 2014
Differentiating between cardiac and obstructive causes for dyspnoea is essential for proper management, but is difficult in the prehospital setting. To assess if prehospital levels of end-tidal carbon dioxide (ETCO2) differed in obstructive compared to cardiac causes of dyspnoea, and could suggest one diagnosis over the other. We conducted a ...
Shah Kevin S KS Department of Internal Medicine, University of California, San Diego, 402 Dickinson Street, Suite 380, San Diego, CA 92103-8425, - - 2014
Heart failure with preserved ejection fraction (HFPEF) is a common subtype of heart failure with morbidity and mortality similar to that of heart failure with systolic dysfunction. This article discusses the numerous biomarkers that promise to play a substantial role in terms of our ability to understand the mechanisms of ...
Gupta Deepak K DK Vanderbilt Heart and Vascular Institute, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Ave, Suite 300, Nashville, TN 37203, - - 2014
Heart failure (HF) with preserved ejection fraction (HFpEF) is becoming the predominant form of HF. Understanding cardiac structure and function in this syndrome is highly relevant for diagnosis, prognosis, pathophysiology, and management. However, identifying cardiac dysfunction in HFpEF can be challenging and requires an integrated assessment of cardiac structure, systolic ...
Denfeld Quin E QE Quin E. Denfeld, BSN, RN PhD Student, School of Nursing, Oregon Health & Science University, Portland. James O. Mudd, MD Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Jill M. Gelow, MD, MPH Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Christopher Chien, MD Assistant Professor, Knight Cardiovascular Institute, Oregon Health & Science University, Portland. Shirin O. Hiatt, MPH, MS, RN Research Associate, School of Nursing, Oregon Health & Science University, Portland. Christopher S. Lee, PhD, RN, FAHA Assistant Professor, School of Nursing and Knight Cardiovascular Institute, Oregon Health & Science University, - - 2014
There is a common dissociation between objective measures and patient symptomatology in heart failure (HF). The aim of this study was to explore the relationship between cardiac biomechanics and physical and psychological symptoms in adults with moderate to advanced HF. We performed a secondary analysis of data from 2 studies ...
King Christopher C Medical Critical Care Service, Inova Fairfax Hospital, 618 South Royal Street, Alexandria, VA 22314, USA. Electronic address: - - 2014
Right ventricular failure complicates several commonly encountered conditions in the intensive care unit. Right ventricular dilation and paradoxic movement of the interventricular septum on echocardiography establishes the diagnosis. Right heart catheterization is useful in establishing the specific cause and aids clinicians in management. Principles of treatment focus on reversal of ...
McKie Paul M PM Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, - - 2014
High-sensitivity cardiac troponin assays have potent prognostic value in stable cardiovascular disease cohorts. Our objective was to assess the prognostic utility of a novel cardiac troponin I (cTnI) high-sensitivity assay, independently and in combination with amino-terminal pro-B-type natriuretic peptide (NT-proBNP), for the future development of heart failure and mortality in ...
Al-Zaiti Salah S SS Department of Acute and Tertiary Care, School of Nursing, University of Pittsburgh, PA, USA. Electronic address: - - 2014
This study evaluated the prognostic value of electrocardiogram (ECG)-based predictors in the primary prevention of sudden cardiac arrest (SCA) among ischemic cardiomyopathy patients with depressed left ventricular ejection fraction (LVEF ≤35%). The prediction of cause-specific mortality in high-risk patients offers the potential for targeting specific therapies (i.e., implantable cardioverter-defibrillator [ICD]). ...
Peng Hui H Section of Electrophysiology, Division of Cardiology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, - - 2014
Left atrial flutter (left AFL) is common in patients who undergo atrial fibrillation ablation and cardiac surgery; however, few reports describe left AFL in detail in a seemingly normally structured heart, and the mechanisms of the occurrence of such arrhythmia are still not clear. We describe left AFL in patients ...
Braunwald Eugene E TIMI Study Group, Cardiovascular Division, Brigham and Women׳s Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
Modern cardiology was born early in the twentieth century. Here I list and review what I believe to be the ten most important advances in the twentieth century in this field. They are as follows: electrocardiography, cholesterol-induced atherosclerosis, cardiac catheterization, cardiovascular surgery, coronary angiography and percutaneous coronary angioplasty, the coronary ...
Edwards Nicola C NC Birmingham Cardio-Renal Group, University of Birmingham and Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. Electronic address: - - 2014
Chronic kidney disease (CKD) is an under-recognized, highly prevalent cardiovascular (CV) risk factor affecting 1 in 7 adults. Large epidemiological studies have clearly established a graded association between the severity of CKD and CV event rates. Although patients with end-stage renal disease who are undergoing dialysis are at greatest CV risk, ...
Asnani Aarti A Massachusetts General Hospital Cardiovascular Research Center, Harvard Medical School, Charlestown, MA 02129, - - 2014
Over the past decade, the zebrafish has become an increasingly popular animal model for the study of human cardiovascular disease. Because zebrafish embryos are transparent and their genetic manipulation is straightforward, the zebrafish has been used to recapitulate a number of cardiovascular disease processes ranging from congenital heart defects to ...
Rana Bushra S BS Consultant Cardiologist at Papworth Hospital, Papworth Everard, Cambridgeshire CB23 - - 2014
This article looks at the role of three-dimensional echocardiography in the anatomical assessment of cardiac structures, how this complements standard methods of assessing structural cardiac lesions and the advantages of three-dimensional echocardiography in peri-procedural guidance in the cardiac catheterization laboratory.
Wu Caijun C Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, - - 2014
The two most prevalent causes of sudden cardiac death are ventricular fibrillation cardiac arrest (VFCA) and asphyxiation cardiac arrest (ACA). Profound postresuscitation myocardial dysfunction has been demonstrated in both VFCA and ACA animal models. Our study aimed to characterize the two porcine models of cardiac arrest and postresuscitation myocardial metabolism ...
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