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Luo Yaping Y From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of - - 2014
Two adult male patients with myocardial infarction underwent Ga-BNOTA-PRGD2 (arginine-glycine-aspartic acid [RGD]) PET/CT scans. The initial images that were acquired within 1 week after the cardiac event showed RGD retention in the infarcted regions in both patients. At follow-up Ga-BNOTA-PRGD2 PET/CT scans, RGD uptake was again noticed in the infracted ...
Singh Sarguni S Department of Internal Medicine, University of Wisconsin School of Medicine and Public Health, Madison, - - 2014
Congestive heart failure (CHF) is an important source of morbidity and mortality in end-stage renal disease patients. Although CHF is commonly associated with low cardiac output (CO), it may also occur in high CO states. Multiple conditions are associated with increased CO including congenital or acquired arteriovenous fistulae or arteriovenous ...
Guiraudon Gerard M GM Canadian Surgical Technologies and Advance Robotics, Lawson Health Research Institute, London Health Science Center, London, Ontario, Canada, - - 2014
This discussion paper re-examines the conduction-activation of the atria, based on observations, with respect to the complexity of the heart as an organ with a brain, and its evolution from a peristaltic tube. The atria do not require a specialized conduction system because they use the subendocardial layer to produce ...
Pietrzyk Edward - - 2014
Extending the length of human life leads to an increase in the elderly population with coronary artery disease. The advanced age does not constitute a contraindication for surgical revascularization. However, according to the available risk scales, the mortality risk associated with performing surgery on patients in the 9th decade of ...
Jędrzejczyk-Patej Ewa E Department of Cardiology, Congenital Heart Disease and Electrotherapy, Silesian Medical University, Silesian Centre for Heart Diseases, Zabrze,. - - 2014
The aim of this study was to evaluate the value of device-based diagnostic parameters in predicting ventricular arrhythmias in cardiac resynchronisation therapy (CRT) recipients. Ninety-six CRT-D patients participating in TRUST CRT Trial were analysed. Inclusion criteria were heart failure in NYHA≥3 class, QRS≥120msec, left ventricular ejection fraction (LVEF)≤35% and significant ...
Cove-Smith Laura L Clinical & Experimental Pharmacology, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, - - 2014
Many efficacious cancer treatments cause significant cardiac morbidity, yet biomarkers or functional indices of early damage, which would allow monitoring and intervention, are lacking. In this study we have utilised a rat model of progressive doxorubicin-induced cardiomyopathy, applying multiple approaches, including cardiac MRI, to provide the most comprehensive characterisation to ...
Fishbein Daniel P DP Seattle Institute for Cardiac Research, Seattle, WA. Electronic address: - - 2014
To determine if six-minute walk assists in treatment decisions for patients with heart failure. In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), prespecified subgroup analysis showed that patients with NYHA Class III symptoms did not benefit from ICD therapy and appeared to be harmed by amiodarone, while NYHA ...
Lin Eric E Simon Fraser - - 2014
The zebrafish (ZF) has emerged as an important model for developmental cardiovascular (CV) biology, however, much less is known about the cardiac function of the adult zebrafish that can be used as a model of teleost CV biology. Here, we describe electrophysiological parameters, such as HR, AP duration (APD) and ...
Kuklik P P Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, - - 2014
The left atrium (LA) plays an important role in the maintenance of hemodynamic and electrical stability of the heart. One of the conditions altering the atrial mechanical function is atrial fibrillation (AF), leading to an increased thromboembolic risk due to impaired mechanical function. Preserving the regions of the LA that ...
Nordberg Per - - 2014
Abstract Background. Cardiac arrest as a consequence of deep accidental hypothermia is associated with high mortality. Standardized prehospital management as well as rewarming with extracorporeal circulation (ECC) are important factors to improve survival. The objective of this case report is to illustrate the importance of effective cardiopulmonary resuscitation (CPR) and ...
Dal-Medico S E SE Universidade Federal de São Carlos, Departamento de Biologia, Rodovia João Leme dos Santos (SP-264), Km 110, 18052-780 Sorocaba, SP, - - 2014
A drastic amphibian decline has been observed worldwide, which can be attributed (among other factors) to exposure to pollutants. Considering that cadmium corresponds to the most rapidly increasing trace metal in the environment, the aim of this work was to evaluate whether the exposure (2 and 16 days) of bullfrog ...
Thomas Penny S PS Department of Biologic and Materials Sciences, University of Michigan -Ann Arbor, 1011 N. University Ave, Ann Arbor, MI-48109, - - 2014
BMP signaling plays an essential role in second heart field-derived heart and arterial trunk development, including myocardial differentiation, right ventricular growth, and interventricular, outflow tract and aortico-pulmonary septation. It is mediated by a number of different BMP ligands, and receptors, many of which are present simultaneously. The mechanisms by which ...
Zapp Eduardo E Laboratory of Biosensors, Department of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil. Electronic address: - - 2014
A label-free electrochemical immunosensor based on the ionic liquid crystal (E)-1-decyl-4-[(4-decyloxyphenyl)diazenyl]pyridinium bromide (Br-Py) coated on a glassy carbon electrode (GCE) for the quantitative detection of myoglobin (Mb), a cardiac marker for acute myocardial infarction, is reported herein for the first time. The monoclonal anti-myoglobin antibody (ab-Mb) was covalently immobilized using ...
Nakajima Kenichi K Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan, - - 2014
Prediction of mortality risk is important in the management of chronic heart failure (CHF). The aim of this study was to create a prediction model for 5-year cardiac death including assessment of cardiac sympathetic innervation using data from a multicenter cohort study in Japan. The original pooled database consisted of ...
Rodríguez Muñoz Daniel D Department of Cardiology, Ramón y Cajal University Hospital, Madrid, - - 2014
Swirling flow, organized in vortices, contributes to adequate left ventricular function. In this study, we apply a novel echocardiographic flow-mapping technique, vector flow mapping (VFM), to evaluate the main characteristics of left ventricular vortices and its relation to filling parameters. Forty-eight subjects underwent conventional transthoracic echocardiographic examination with additional intracardiac ...
Ermacora Davide D Department of Cardiac, Vascular and Thoracic Sciences, University of Padua, Padua, - - 2014
Three-dimensional echocardiography (3DE) is a unique cardiovascular imaging modality in terms of: ability to provide realistic anatomical views of cardiac structures in the beating heart and possibility to visualize cardiac structures from any desired perspective. Therefore, 3DE is emerging as an accurate imaging modality for a prompt diagnosis and detailed ...
Frangogiannis Nikolaos G NG The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer G46B, Bronx, NY 10461, - - 2014
Myocardial infarction triggers an intense inflammatory response that is essential for cardiac repair, but which is also implicated in the pathogenesis of postinfarction remodelling and heart failure. Signals in the infarcted myocardium activate toll-like receptor signalling, while complement activation and generation of reactive oxygen species induce cytokine and chemokine upregulation. ...
Nalos Marek - - 2014
Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end organ dysfunction. Treatment often includes a combination of diuretics, oxygen, positive pressure ventilation, inotropes and vasodilators or vasopressors. Lactate is a marker of illness severity but is also an important metabolic substrate ...
Langrish Jeremy P JP University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United - - 2014
Epidemiological studies have demonstrated that air pollution exposure is associated with increases in cardiovascular morbidity and mortality. Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups. To investigate the incidence of cardiac ...
Guerrero Orriach Jose L - - 2014
Preoperative use of levosimendan in cardiac surgery patients is one of the most attractive therapeutic alternatives in subjects with left or right ventricular dysfunction. Our review explores the pharmacological bases and clinical evidence for the use of levosimendan, with the intention of making a series of recommendations regarding its use ...
Thireau Jérôme J Inserm U1046, Physiologie & Médecine Expérimentale, Cœur et Muscles, Université Montpellier-1 & 2, , Montpellier, - - 2014
Clinical studies failed to prove convincingly efficiency of intravenous infusion of neseritide during heart failure and evidence suggested a pro-adrenergic action of B-type natriuretic peptide (BNP). However, subcutaneous BNP therapy was recently proposed in heart failure, thus raising new perspectives over what was considered as a promising treatment. We tested ...
Borisenko Oleg O Synergus AB, Danderyd, - - 2014
The objective of the study was to assess the cost of using different blood pumps for short-term ventricular assist device (VAD) and extracorporeal life support (ECLS) systems for cardiac and cardiorespiratory failure in the UK. The cost analysis presented was based on evaluation of the time required to provide circulatory ...
Motoki Hirohiko H Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
Right ventricular (RV) global longitudinal strain (RV strain) is a sensitive measure of RV mechanics. Its relationship with standard clinical markers and long-term events in chronic systolic heart failure is not well established. The aim of this study was to examine the ability of RV strain to provide incremental prognostic ...
Kumar Arun - - 2014
After a cardiac event, proper treatment and care of the damaged tissue is crucial in restoring optimal cardiac function and preventing future cardiac events. Recently, thymosin beta4 has been found to play a vital role in cardiac cell health and development by regulating angiogenesis, inflammatory responses, and wound healing. We ...
Wickham Abeni M AM Integrative Regenerative Medicine (IGEN) Centre and Department of Physics, Chemistry and Biology, Linköping University, Linköping, - - 2014
The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent ...
Kumarswamy Regalla R IMTTS, Hannover Medical - - 2014
Long non-coding RNAs (lncRNAs) represent a novel class of molecules regulating gene expression. LncRNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease. Role of lncRNAs as potential biomarkers in heart disease. Global transcriptomic analyses were done in plasma RNA from patients with/without ...
Holloway Cameron J CJ 1 Department of Physiology, Anatomy and Genetics, University of Oxford , United Kingdom - - 2014
Abstract Holloway, Cameron J., Andrew J. Murray, Kay Mitchell, Daniel S. Martin, Andrew W. Johnson, Lowri E. Cochlin, Ion Codreanu, Sundeep Dhillon, George W. Rodway, Tom Ashmore, Denny Z.H. Levett, Stefan Neubauer, Hugh E. Montgomery, Michael P.W. Grocott, and Kieran Clarke, on behalf of the Caudwell Xtreme Everest 2009 Investigators. ...
Yoshihisa Akiomi A Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan; Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan. Electronic address: - - 2014
Chronic obstructive pulmonary disease (COPD) often coexists with heart failure (HF), and is considered to be associated with adverse outcomes in HF patients. However, the features of cardiovascular function and the detailed all-cause mortality of HF with COPD remain unclear. Consecutive 378 patients admitted for HF who underwent spirometry were ...
Marui Akira A Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Ischaemic heart disease is a major risk factor for heart failure. However, long-term benefit of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in those patients has not been well elucidated. Of the 15 939 patients undergoing first myocardial revascularization enrolled in the CREDO-Kyoto PCI/CABG Registry Cohort-2, we ...
Kishima Hideyuki H Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan, - - 2014
Some patients experience a left atrial thrombus (LAT) in spite of taking warfarin. We aimed to clarify the characteristics of patients with LAT during warfarin administration and investigated whether the CHADS2 or CHA2DS2-VASc scores are useful predictors of LAT. We studied 230 patients (169 males, age 65 ± 10 years) who underwent transesophageal ...
Kasama Shu S Department of Medicine and Biological Science (Cardiovascular Medicine), Gunma University Graduate School of Medicine, 3-39-15, Showa-machi, Maebashi, Gunma, 371-0034, Japan, - - 2014
Aldosterone prevents the uptake of norepinephrine in the myocardium. Atrial natriuretic peptide (ANP), a circulating hormone of cardiac origin, inhibits aldosterone synthase gene expression in cultured cardiocytes. We evaluated the effects of intravenous ANP on cardiac sympathetic nerve activity (CSNA) and aldosterone suppression in patients with acute decompensated heart failure ...
Zhao Baoyin B Key Laboratory for Regenerative Medicine, Ministry of Education, Ji Nan University, Guangzhou, China; Joint Laboratory for Regenerative Medicine, Chinese University of Hong Kong-Ji Nan University, Guangzhou, China; International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Guangzhou, China; Department of Developmental and Regenerative Biology, Ji Nan University, Guangzhou, - - 2014
The midterm effects of cardiac telocytes (CTs) transplantation on myocardial infarction (MI) and the cellular mechanisms involved in the beneficial effects of CTs transplantation are not understood. In the present study, we have revealed that transplantation of CTs was able to significantly decrease the infarct size and improved cardiac function ...
Zeng Zhi - - 2014
Histamine H2receptor (H2R) blockade has been reported to be beneficial for chronic heart failure, but the mechanisms involved are not entirely clear.Here we assessed the influences of H2R disruption on the left ventricular (LV) dysfunction and the mechanisms involved in mitochondrial dysfunction and calcineurin-mediated myocardial fibrosis.H2R knockout mice and their ...
Tomcsányi János J From the Department of Cardiology, Hospital of the Hospitaller Brothers of St. John of God, Budapest, - - 2014
A 40-year-old woman with history of familiar cardiac sarcoidosis reported having palpitations, shortness of breath and experiencing several implantable cardioverter-defibrillator (ICD) shocks for the last few hours. On admission to the coronary care unit, the electrocardiogram (Figure 1) showed wide QRS complex tachycardia at a rate of 149 per minute. ...
Seok Heeyoung Y HY Department of Cardiology, Harvard Medical - - 2014
In response to mechanical and/or pathological stress, adult mammalian hearts often undergo mal-remodeling, a process commonly characterized as pathological hypertrophy, which is associated with upregulation of fetal genes, increased fibrosis, and reduction of cardiac dysfunction. The molecular pathways that regulate this process are not fully understood. To explore the function ...
Maisano Francesco F aOspedale San Raffaele bCentro Cardiologico Monzino cIstituto Scientifico S. Ambrogio, Milan dOspedale Campo Di Marte, Lucca eOspedale Niguarda, Milan fClinica Villa Maria, Cotignola gCardiologia, Università e Spedali Civili, Brescia hPoliclinico San Donato, Milan iOspedale Careggi, Firenze jOspedale Genova, Genova kA. O. Papa Giovanni XXIII, Bergamo lOspedale Ferrarotto, Catania mCardiologia Tor Vergata, Rome, - - 2014
New percutaneous technologies are rapidly emerging for the treatment of structural heart disease including mitral valve disease. Preliminary data suggest a potential clinical benefit of percutaneous treatment of mitral regurgitation by the MitraClip procedure in selected patients. Until final data are available from randomized, controlled, multicenter clinical trials, there is ...
Sala Michiel L ML Department of Radiology, Leiden University Medical Center, Leiden, The - - 2014
Computed tomography is a noninvasive imaging modality that can be used for the evaluation of cardiac structure and function. This review provides an overview of established and emerging applications of cardiac computed tomography, including evaluation of left and right ventricular function, ventricular morphology, native and prosthetic valves, and pulmonary and ...
Rusu Cristian - - 2014
This paper aims to identify approaches that generate appropriate synthetic data (computer generated) for Cardiac Phase-resolved Blood-Oxygen-Level-Dependent (CP-BOLD) MRI. CP-BOLD MRI is a new contrast agent- and stressfree approach for examining changes in myocardial oxygenation in response to coronary artery disease. However, since signal intensity changes are subtle, rapid visualization ...
Kamal Fadia A FA The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
elevated sympathetic nervous system activity is a salient characteristic of heart failure (HF) progression. It causes pathologic desensitization of β -adrenergic receptors (β -AR), facilitated predominantly through Gβ γ-mediated signaling. The adrenal glands are key contributors to the chronically elevated plasma catecholamine levels observed in HF, where adrenal α2-AR feedback ...
Haensch Carl-Albrecht CA Department of Neurology, Maria Hilf Kliniken Mönchengladbach, University of Witten/Herdecke, - - 2014
Introduction: Postural tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterized by excessive tachycardia of unknown etiology. Our objective was to evaluate the correlation between C-fiber involvement shown by skin biopsy and adrenergic cardiac MIBG-uptake in POTS patients. Methods: Skin biopsies of 84 patients with POTS were examined by ...
Biteker Murat - - 2014
Peripartum cardiomyopathy (PPCM) is a form of idiopathic dilated cardiomyopathy affecting women in late pregnancy or early puerperium. Although initially described in the late 1800s, it has only recently been recognized as a distinct cardiac condition. The reported incidence and prognosis varies according to geography. The clinical course varies between ...
Stoupel Eliiyahu E Division of Cardiology, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, - - 2014
Many publications in recent decades have reported a temporal link between medical events and environmental physical activity. The aim of this study was to analyze the time of occurrence of electrical heart storms against levels of cosmological parameters. The sample included 82 patients (71 male) with ischemic cardiomyopathy treated with ...
Rath Claus - - 2014
Pacemaker lead malpositioning with subsequent cardiac tamponade is a rare, but serious adverse event. We herein report a case of pacemaker lead malpositioning in a 76-year old female caucasian patient. The lead was malpositioned into the roof of the left atrium after perforation of the superior vena cava, resulting in ...
Liu Shanxin S Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, - - 2014
Atrial fibrillation (AF) is the most common arrhythmic complication after cardiac surgery. Several studies have compared the efficacy of landiolol and placebo or other agents in preventing new-onset AF in patients after cardiac surgery. In this study, we conducted a meta-analysis to determine whether landiolol is effective in preventing new-onset ...
Kim Tae Kyum TK Department of Biomedical Science, Hallym University, Chuncheon, South Korea; BodiTech Med, Inc, Chuncheon, South - - 2014
Myoglobin, creatine kinase-MB isoenzyme (CK-MB), and cardiac troponin I (cTnI) are cardiac biomarkers that are widely used to assist in the early and late diagnoses of acute myocardial infarction (AMI). Here, we present a clinically applicable fluorescence (FL) immunoassay for cardiac biomarkers. Whole blood was mixed with FL-labeled detector Ab ...
Domsik Péter P 2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, - - 2014
Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric ...
Furtado Milena B MB Australian Regenerative Medicine Institute, Monash - - 2014
Cardiac fibroblasts are critical to proper heart function through multiple interactions with the myocardial compartment but appreciation of their contribution has suffered from incomplete characterization and lack of cell-specific markers. To generate an unbiased comparative gene expression profile of the cardiac fibroblast pool, identify and characterize the role of key ...
Claveau David D Department of Emergency Medicine, Centre de santé et de services sociaux de Trois-Rivières, Centre hospitalier affilié universitaire régional, Trois-Rivières, Quebec, - - 2014
Cardiac tamponade from necrotizing descending mediastinitis is a rare but life-threatening complication of cervicofacial infections. A 49-year-old woman presented in shock with pleuretic chest pain at a small community clinic. She was transferred to our emergency department where cardiac tamponade was diagnosed and drained. Her initial complete blood count and ...
Petri Helle H Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: - - 2014
Patients with myotonic dystrophy type 1 (DM1) have a three-fold higher risk of sudden cardiac death (SCD) than age-matched healthy controls. Despite numerous attempts to define the cardiac phenotype and natural history, existing literature suffers from low power, selection-bias and lack of controls. Thus, the optimal strategy for assessing cardiac ...
Sohns J M JM Institute for Diagnostic and Interventional Radiology, University Medical Center of Georg-August-University, - - 2014
Purpose: The aim of this study was to assess the incidence of cardiac and significant extra-cardiac findings in clinical computed tomography of the heart in patients with atrial fibrillation before pulmonary vein isolation (PVI). Materials and Methods: 224 patients (64 ± 10 years; male 63 %) with atrial fibrillation were examined by cardiac ...
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