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Giovanardi P P Medicina Cardiovascolare, Nuovo Ospedale S.Agostino-Estense, Modena, Italy - - - 2014
to better understand interactions between Left Ventricular (LV) and Right Ventricular (RV) systolic and diastolic function echocardiographic indexes in stable cardiovascular diseased patients and in subjects with cardiovascular risk factors. 683 stable patients were submitted to standard transthoracic echocardiography with evaluation of Left Ventricular Ejection Fraction (LVEF) (Simpson biplane method), ...
Abu-El-Haija Basil B Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, - - 2014
Electrical cardioversion (EC) for atrial fibrillation (AF) is a common procedure performed in an attempt to restore normal sinus rhythm (NSR). Many factors predict long-term maintenance of NSR and the risk of AF recurrence. The duration of AF, cardiac size and function, rheumatic heart disease, significant mitral valve disease, left ...
Nuñez Rebeca E RE Department of Physiology, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, Puerto Rico - - 2014
Recent studies indicate that the cardioprotective effects of ischemic preconditioning (IPC) against sustained ischemia/reperfusion (IR) can be replicated by angiotensin II (Ang II). However, it is not clear whether IPC and Ang II-induced preconditioning (APC) act through similar mechanisms or synergize to enhance cardioprotection. In this study, Langendorff-perfused rat hearts ...
Xu Aijun A Virginia Commonwealth University, Huazhong University of Science and - - 2014
The reversible inhibition of mitochondrial respiration by complex I inhibition at the onset of reperfusion decreases injury in buffer perfused hearts. Administration of acidic reperfusate for a brief period at reperfusion decreases cardiac injury. We asked if acidification treatment decreased cardiac injury during reperfusion by inhibiting complex I. Exposure of ...
Nakamura Tamami T Department of Cardiovascular Surgery, Saiseikai Shimonoseki General Hospital, Yamaguchi, - - 2014
Cardiac hemangiopericytoma is a rare soft tissue tumor. We describe a case of hemangiopericytoma in the left atrium, which was diagnosed as myxoma preoperatively. A 70-year-old woman was admitted with heart failure. An echocardiogram showed a large myxoma-like mass in the left atrium, herniating into the left ventricle; therefore, an ...
Pourafkari Leili L Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
Atrial fibrillation is a complication of mitral valve stenosis that causes several adverse neurologic outcomes. Our objective was to establish a mathematical model to predict the risk of atrial fibrillation in patients with mitral stenosis. Of 819 patients with mitral stenosis who were screened, 603 were enrolled in the study ...
Malfatto Gabriella G aDivisione di Cardiologia, Ospedale San Luca, Istituto Auxologico Italiano IRCCS bDipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università di Milano-Bicocca, Milano, Milano, - - 2014
Optimization of inotropic treatment in worsening heart failure sometimes requires invasive hemodynamic assessment in selected patients. Impedance cardiography (ICG) may be useful for a noninvasive hemodynamic evaluation. ICG was performed in 40 patients (69 ± 8 years; left ventricular ejection fraction 27.5 ± 5.6%; New York Heart Association 3.18 ± 0.34; Interagency Registry for Mechanically Assisted ...
Shrestha Ayush A Department of Pharmacology, JSS College of Pharmacy (A constituent college of JSS University, Mysore), Ootacamund, Tamilnadu, - - 2014
To determine the protective role of a soluble epoxide hydrolase(sEH) inhibitor, trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido] cyclohexyloxy} benzoic acid (t-TUCB), in isoproterenol (ISO)-induced myocardial ischaemic injury in vivo. Cardioprotective activity of t-TUCB was studied against ISO-induced myocardial ischaemic injury in male Wistar rats. Cardioprotection was assessed by measuring elecrocardiographic (EKG), serum lactate dehydrogenase (LDH) ...
Sievi Noriane A - - 2014
Altered cardiac repolarization and increased dispersion of repolarization have been identified as risk factors for sudden cardiac death (SCD). The prevalence of and the mechanisms contributing to altered cardiac repolarization are currently unknown in COPD. In 91 COPD patients, 32 controls matched for age, cardiovascular risk and medication, and 41 ...
Moubarak Ghassan G Department of Pacing and Interventional Electrophysiology, Groupe Hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75014 Paris, France. Electronic address: - - 2014
Insufficient correction of mechanical dyssynchrony is a cause of non-response to cardiac resynchronization therapy (CRT). To determine if CRT delivery could be optimized during the implantation procedure by choosing the number and location of pacing sites using echocardiography guidance. In patients with a QRS≥150ms or a QRS<150ms and criteria for ...
Lee Ga Yeon GY Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
To determine how often left ventricular wall thickness (LVWT) is normal and to assess the effect of LVWT on clinical outcomes of patients with immunoglobulin light chain (AL) cardiac amyloidosis. A total of 117 patients with systemic AL amyloidosis were retrospectively categorized from April 1, 1995, to September 15, 2012; ...
Ferrario Carlos Maria - - 2014
Lessons learned from the characterization of the biological roles of Ang-(1-7) [angiotensin-(1-7)] in opposing the vasoconstrictor, proliferative and prothrombotic actions of AngII (angiotensin II) created an underpinning for a more comprehensive exploration of the multiple pathways by which the RAS (renin-angiotensin system) of blood and tissues regulates homoeostasis and its ...
Rickard John J Division of Cardiology, The Johns Hopkins Hospital, Baltimore, - - 2014
Cardiac resynchronization therapy (CRT) is an important therapy in heart failure but 30 %‒40 % of patients may not respond. Improving this rate is an important goal and requires attention to candidate selection, intraoperative procedure, and postoperative follow-up. Factors to be considered are QRS morphology, duration, and left ventricular lead position with ...
Todaro Maria Chiara MC Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, - - 2014
Viable treatment options for advanced heart failure have not emerged as the number of people afflicted with this condition has grown. Although heart transplantation is the only curative strategy for patients with end-stage heart failure, the relative shortage of donors has led to a worldwide plateau of this option over ...
Mullin Megan K MK University of Pennsylvania, School of Nursing, Adult-Gerontology Acute Care Nurse Practitioner Program, Philadelphia. Ms Mullin is now with the Division of Cardiothoracic Surgery, Thomas Jefferson University Hospital, Philadelphia, - - 2014
In the United States, approximately 1.7 million cardiac catheterizations are performed each year, making it the fifth most common procedure. In this article, the author reviews the literature on the alternative transradial approach versus the traditional transfemoral approach for cardiac catheterization. Through a meta-analysis, clinical trials were thoroughly analyzed. The ...
Le Goff C C University Hospital of Liège, Liège, - - 2014
Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight protein involved in the intracellular uptake and buffering of long chain fatty in the myocardium. Troponin T is a component of the contractile apparatus of the striated musculature. Both are early markers for acute coronary syndrome. The aim of our ...
Toresdahl B B University of Washington, Seattle, - - 2014
The primary objective of pre-participation screening in athletes is the detection of potentially lethal cardiac conditions. The American Heart Association (AHA) recommends a directed history and physical examination. The added value of electrocardiogram (ECG) screening is debated.     % of Abnormalities DetectedFalse Positive RatePositive Predictive ValueHistory47.8%22.3%1.0%Physical30.4%14.9%1.0%ECG69.6%3.6%8.6% To determine the effectiveness ...
Singh Sonal S Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
The majority of deaths in COPD are from cardiovascular causes. Several large randomized controlled trials demonstrate that inhaled anticholinergic agents ipratropium and tiotropium increase the risk of serious cardiovascular events, including cardiovascular mortality. Tiotropium Respimat is associated with a statistically significant increased risk of mortality (RR 1.52; 95% CI 1.06 ...
Thihalolipavan Sudarone S Department of Cardiology, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address: - - 2014
Heart failure (HF) and atrial fibrillation (AF) commonly coexist and adversely affect mortality when found together. AF begets HF and HF begets AF. Rhythm restoration with antiarrhythmic drugs failed to show a mortality benefit but can be effective in improving symptoms. Nonpharmacologic treatment of AF may be of value in ...
Gayanilo Marjorie A MA Department of Pediatric Cardiology, Holtz Children's Hospital, University of Miami Miller School of Medicine, Miami, FL, - - 2014
Transmyocardial migration of a retained temporary epicardial pacing wire has been rarely reported in adult patients after heart surgery. We present the case of a child in whom a temporary epicardial pacing wire was discovered incidentally in the right ventricular outflow tract one year after surgical repair of congenital heart ...
Fiore A A Department of Cardiovascular Surgery and Heart Transplantations, ILCV Louis-Mathieu CHU Nancy, Vandoeuvre-lès-Nancy, France - - - 2014
Catheter ablation is a well-established therapeutic option for management of recurrent ventricular tachycardia in patients with ischemic/non-ischemic heart disease and procedural complications include a mortality rate of up to 3% and a risk of major complications up to 10%. Cardiac perforation following a catheter ablation is rare but serious complication ...
Tan Jing J Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of - - 2014
We evaluated the temporal association between aortic arterial stiffness and subclinical target organ damage, including renal function decline, left ventricular geometric remodeling, and left ventricular diastolic dysfunction in patients with mild hypertension. Automatic pulse wave velocity (PWV) measuring system was applied to examine carotid-femoral PWV (CFPWV) reflecting aortic arterial stiffness ...
Alibhai Faisal J FJ Biomedical Sciences, University of - - 2014
Patients in Intensive Care Units (ICU) are disconnected from their natural environment. Synchrony between environmental diurnal rhythms and intracellular circadian rhythms is essential for normal organ biology; disruption causes pathology. Whether disturbing rhythms post myocardial infarction (MI) exacerbates long-term myocardial dysfunction is not known. Short term diurnal rhythm disruption immediately ...
Fan Dong D Department of - - 2014
Tissue inhibitor of metalloproteinases (TIMPs) can mediate myocardial remodelling, hypertrophy and fibrosis in heart disease. We investigated the impact of TIMP2- versus TIMP3-deficiency in angiotensin II (Ang II)-induced myocardial remodeling and cardiac dysfunction.Methods and ResultsTIMP2(-/-), TIMP3(-/-) and wildtype (WT) mice received Ang II/saline (Alzet pump) for 2 weeks. Ang II ...
Niebler Robert A RA Herma Heart Center, Children's Hospital of Wisconsin, Milwaukee, Wisconsin; Department of Pediatrics, Section of Critical Care, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: - - 2014
We present a successful case of the use of a HeartWare ventricular assist device as a bridge to transplantation in an 11-year-old with a hypoplastic left heart and failed Fontan circulation.
Rossano Joseph W JW Division of Cardiology, Department of Pediatrics, The Cardiac Center, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: - - 2014
Typical left ventricular assist devices are often ineffective for the failing Fontan circulation. We report the first successful use of a total artificial heart as a bridge to transplant in a patient who had previously undergone a Fontan operation.
McKernan Nicholas P NP Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine, Temple, - - 2014
We present what may be the first documented case of takotsubo cardiomyopathy following a thoracic epidural steroid injection. The 77-year-old patient had many risk factors predisposing her to takotsubo cardiomyopathy, including gender, postmenopausal status, and numerous recent stressful events in her life. Although she presented to the emergency department with ...
Kang Patrick T PT From the Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH - - 2014
A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known inhibitor of cytosolic GR ex vivo and in vivo. Here we tested the hypothesis that a BCNU-induced GR2 defect ...
Partyka Christopher C Department of Emergency Medicine, Liverpool Hospital, Sydney, New South Wales, - - 2014
Ventricular assist devices (VADs) have become an indispensable tool in the management of end-stage cardiac failure, both as a means of bridging to cardiac transplantation and as destination therapy for long-term quality of life improvement. Although the technology continues to advance and these devices continue to be refined, they are ...
Butler Javed J Department of Medicine, Emory Cardiovascular Clinical Research Institute, Emory University, Atlanta, Georgia. Electronic address: - - 2014
The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary ...
Garg Vishal V Department of Cardiothoracic and Transplant Anaesthesia, Freeman Hospital, Newcastle Upon Tyne, United - - 2014
Nitric oxide (NO) is a selective pulmonary vasodilator especially in the presence of pulmonary artery hypertension. With right ventricle (RV) dysfunction, inhaled NO may increase RV ejection fraction and cardiac output. The main advantage of NO over intravenous therapy is its inability to decrease systemic pressure thereby maintaining the coronary ...
Kook Lee Byung B The Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of - - 2014
Several studies in patients who underwent open heart surgery found that myocardial ischemic damage was reduced by potassium cardioplegia combined with lidocaine infusion. The authors evaluated the effects of potassium/lidocaine-induced cardiac standstill during conventional cardiopulmonary resuscitation (CPR) on myocardial injury and left ventricular dysfunction after resuscitation from prolonged ventricular fibrillation ...
Hool Livia C LC The University of Western Australia, M311 Anatomy, Physiology and Human Biology, 35 Stirling Highway, Crawley, Perth, Western Australia, Australia, 6009, 61864883307, 61864881025 ; - - 2014
Significance: Oxygen occupies a key role in cellular metabolism and function. Oxygen delivery to cells is crucial and a lack of oxygen such as occurs during myocardial infarction can be lethal. Cells must therefore be able to respond to changes in oxygen tension. Recent advances: Since the first studies examining ...
Aliberti Stefano S aDepartment of Health Science, University of Milan-Bicocca, Respiratory Dept, AO San Gerardo, Monza, Italy bChief, Division of Infectious Diseases and Professor of Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky, - - 2014
The aim is to evaluate basic mechanisms, prevalence, risk factors, outcomes, and potential treatments of cardiovascular events (CVEs) in patients with community-acquired pneumonia (CAP). In this review, we present a new model to evaluate the pathophysiology of cardiac disease in patients with pneumonia based on plaque-related events, such as acute ...
Hartman Matthew E ME *Division of Cardiology, Department of Medicine, and †Department of Pathology, Institute for Stem Cells and Regenerative Medicine, University of Washington, Seattle, Washington, USA; - - 2014
CHF1/Hey2 is a Notch-responsive basic helix-loop-helix transcription factor involved in cardiac development. Common variants in Hey2 are associated with Brugada syndrome. We hypothesized that absence of CHF1/Hey2 would result in abnormal cellular electrical activity, altered cardiac conduction system (CCS) development, and increased arrhythmogenesis. We isolated neonatal CHF/Hey2-knockout (KO) cardiac myocytes ...
Yang Hao H Department of Cardiology, Nanfang Hospital, Southern Medical University,Guangzhou 510515, - - 2014
PATIENTS with chronic heart failure (CHF) have a high incidence of atrial/ventricular arrhythmias which seriously affect life span and quality of life. Cardiac re-synchronization therapy (CRT) can improve cardiac function and reverse myocardial remodeling, therefore improving the quality of life and reducing mortality. CRT with Home-Monitoring (HM) can be used ...
Goldenberg Ilan I The authors' affiliations are listed in the - - 2014
Background The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac-resynchronization therapy with a defibrillator (CRT-D) in patients with an electrocardiographic pattern showing left bundle-branch block was associated with a significant reduction in heart-failure events over a median follow-up of 2.4 years, as ...
Abd El Rahman Mohamed Y MY Department of Pediatric Cardiology, Saarland University Hospital, Kirrberger Straße, 66421, Homburg/Saar, - - 2014
The effect of bosentan on the ventricular and atrial performance in patients with Eisenmenger syndrome is unclear. In adult patients with Eisenmenger syndrome, we aimed to evaluate the midterm effect of bosentan on physical exercise, ventricular and atrial function, and pulmonary hemodynamics. Forty adult patients before and after 24 weeks bosentan ...
Goldberger Jeffrey J JJ From the Center for Cardiovascular Innovation and the Division of Cardiology, Feinberg School of Medicine, Northwestern University, - - 2014
Cardiac-resynchronization therapy (CRT), also known as biventricular pacing, has emerged as a pivotal therapy in selected patients with heart failure with reduced ejection fraction. The mechanism of benefit of CRT is complex and not yet completely understood, but it is probably multifactorial, with effects on contractile function, β-adrenergic responsiveness, and ...
Verschure Derk O DO Department of Nuclear Medicine, Room F2-238, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The - - 2014
The purpose of this study was to determine the most appropriate prognostic endpoint for myocardial (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with chronic heart failure (CHF) based on aggregate results from multiple studies published in the past decade. Original individual late (3-5 h) heart/mediastinum (H/M) ratio data of 636 CHF patients ...
Sommer Anders A Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, Aarhus N DK-8200, - - 2014
Fluoroscopy is the routine method for localizing left ventricular (LV) and right ventricular (RV) lead positions in cardiac resynchronization therapy (CRT). However, the ability of fluoroscopy to determine lead positions in a standard ventricular segmentation is unknown. We aimed to evaluate the accuracy and reproducibility of fluoroscopy to determine LV ...
Florian Anca A Department of Cardiology and Angiology, University Hospital Münster, Albert-Schweitzer-Campus 1, building A1, 48149 Münster, - - 2014
Cardiac involvement with progressive myocardial fibrosis leading to dilated cardiomyopathy is a major cause of death in muscular dystrophy patients. Extracellular volume fraction (ECV) measurement based on T1-mapping pre- and post-contrast promises the detection of early 'diffuse' myocardial fibrosis that cannot be depicted by conventional contrast-imaging based on late gadolinium ...
Cai Jindan J Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, - - 2014
Evaluation of cardiac reserve under myocardial infarction in patients is important for prognosis. However, this evaluation is difficult to be done due to high risk for mortality in patients with severe myocardial infarction. The present study was undertaken using non-human primate model as a substitute for humans to investigate the ...
Lenneman Carrie Geisberg CG Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA, - - 2014
The National Cancer Institute estimates that approximately 13.7 million Americans with a history of cancer were alive on January 1, 2012. With the rising number of cancer survivors, there is an increased focus on how chemotherapy agents modulate the cardiovascular biology and cause chemotherapy-related heart failure in certain patients. Neuregulin-1 ...
Chen Bing-Wei BW Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Beijing, 100037, People's Republic of - - 2014
Cardiac pacing can be used to treat carotid sinus syndrome (CSS), but clinical studies have shown conflicting results. We conducted a systematic review and meta-analysis to evaluate the role of pacing for CSS. A systematic search of publications in PubMed, Embase, and the Cochrane Library without language restriction was performed. ...
Alpert Martin A MA University-Columbia Division of Cardiovascular Medicine, University of Missouri Health Sciences Center, Room CE-306, 5 Hospital Drive, Columbia, MO, 65212, USA, - - 2014
Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well ...
Houmsse Mahmoud M The Ohio State University Wexner Medical Center - Cardiovascular Medicine, Heart and Lung Research Institute, 473 W. 12th Avenue Second floor, Columbus, OH 43235, - - 2014
Cardiac resynchronization therapy (CRT) is a well-established therapy to reduce morbidity and mortality in patients with moderate and severe symptomatic congestive heart failure. Left ventricular (LV) pacing that fuses with intrinsic right ventricular (RV) conduction results in similar or even better cardiac performance compared to biventricular (Biv) pacing. Optimal programming ...
Radovanovic Slavica S Odeljenje Kardiologije, Klinicko-Bolnicki Centar Bezanijska Kosa, Belgrado, - - 2014
Uric acid and gamma-glutamyl transferase are prognostic indicators in chronic heart failure. Nevertheless, the mechanism underlying the association between uric acid, gamma-glutamyl transferase, and chronic heart failure progression and prognosis remains largely unknown. The association of uric acid and gamma-glutamyl transferase with flow-mediated dilation and echocardiographic indices of cardiac remodeling ...
Weymann Alexander - - 2014
The purpose of this prospective study was to evaluate the effects and functional outcome of central extracorporeal life support (ECLS) with left ventricular decompression for the treatment of refractory cardiogenic shock and lung failure. Between August 2010 and August 2013, 12 consecutive patients (2 female) with a mean age of ...
Lip Gregory Yh GY University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham, UK, B18 - - 2014
Patients with chronic heart failure (heart failure) are at risk of thromboembolic events, including stroke, pulmonary embolism and peripheral arterial embolism, whilst coronary ischaemic events also contribute to the progression of heart failure. Long-term oral anticoagulation is established in certain patient groups, including patients with heart failure and atrial fibrillation, ...
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