Search Results
Results 51 - 100 of 7359
1 2 3 4 5 6 7 8 9 10 >
Park Yeonjeong Y Cardiology Division, Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Republic of - - 2014
Premature ventricular complex (PVC) has been regarded as benign; however, when frequent, the arrhythmia can induce left ventricular (LV) systolic dysfunction. Meanwhile, the influence of PVCs on cardiac structural remodeling and functional change before occurrence of overt systolic heart failure has not been fully described. In this study, we attempted ...
DeKoninck Philip P Fetal Medicine Unit, Department of Obstetrics and Gynecology, University Hospitals Leuven & Cluster Organ Systems, Department of Development and Regeneration, KU Leuven, Leuven, - - 2014
To evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking. Case-control study assessing cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected ...
Link Mark S MS Tufts Medical Center, Cardiac Arrhythmia Center, Boston, Massachusetts. Electronic address: - - 2014
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with sudden cardiac death. However, the selection of patients for implanted cardioverter-defibrillators (ICDs), as well as programming of the ICD, is unclear. The objective of this study was to identify predictors, characteristics, and treatment of ventricular arrhythmias in patients with ARVC. The Multidisciplinary Study ...
Jagu B B Research unit of l'Institut du thorax, Nantes, - - 2014
The sodium channel Nav1.5, encoded by the Scn5a gene, is responsible for the excitability and the conduction velocity of electrical impulses through the heart. Nav1.5 mutations are involved in rhythmic or structural pathologies. During the acute phase of myocardial infarction (MI), arrhythmias were associated with an increased risk of mortality. ...
Lindner D D University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, - - 2014
Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with outcome in patients. However, the basis for the development of both remains unclear. We have previously reported that cardiac inflammation triggers transdifferentiation of fibroblasts to myofibroblasts and therefore increase accumulation of cardiac collagen deposition, one key pathology in ...
Weithaeuser A A Charite - University Medicine, Campus Benjamin Franklin, Berlin, - - 2014
Elderly patients often suffer from left ventricular hypertrophy and diastolic dysfunction with preserved systolic function resulting from ongoing cardiomyocyte loss and cardiac fibrosis. The protease activated receptor (PAR) 2 is known to be a pro-fibrotic mediator. In a mouse model of myocardial infarction PAR2 overexpression in cardiomyocytes led to the ...
Hwang Sung Ho SH Department of Radiology, Anam Hospital College of Medicine, Korea University, Seoul, South - - 2014
To establish extracellular volume fraction (ECV) thresholds corresponding to myocardial lesion detected by late-gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging. Fifty-six patients with myocardial infarction or hypertrophic cardiomyopathy underwent LGE, pre- and post-contrast modified Look-Locker inversion recovery (MOLLI) sequences on a 3-T CMR system. Short-axis MOLLI images generated ECV ...
Holmen Y D YD Oslo University Hospital, Research Institute of Internal Medicine, Oslo, - - 2014
Experimental studies have shown a central role for Toll-like receptor 9 (TLR9) in the pathogenesis of heart failure (HF). There is also evidence that mitochondrial DNA (mtDNA) not confined within the mitochondrion may act as a TLR9 ligand. However, it is unknown whether these findings also have a human correlate. ...
Ishikawa Kiyotake K Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, - - 2014
Cardiac gene therapy has emerged as a promising option to treat advanced heart failure. Advances in molecular biology and gene targeting approaches are offering further novel options for genetic manipulation of the cardiovascular system. The aim of this study was to improve cardiac function in chronic heart failure by over-expressing ...
Li Jun J 1] Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China [2] Institute of Medical Genetics, Tongji University, Shanghai 200092, - - 2014
Pathological cardiac hypertrophy is an inevitable forerunner of heart failure. Regardless of the etiology of cardiac hypertrophy, cardiomyocyte mitochondrial alterations are always observed in this context. The translocases of mitochondrial outer membrane (Tom) complex governs the import of mitochondrial precursor proteins to maintain mitochondrial function under pathophysiological conditions; however, its ...
Matsumoto Takashi T Heart Institute, Cedars-Sinai Medical - - 2014
Recent advances in structural heart intervention have produced increasing demand for transseptal access, which was first introduced as a diagnostic tool to directly measure left atrial pressure. Transseptal access allows safe and adequate approach to the left atrium and surrounding structures. Percutaneous transcatheter mitral valve repair using the MitraClip device ...
Saito Tomohiro T Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany - - 2014
A left ventricular pseudoaneurysm develops when myocardial rupture is contained by the pericardium. Although left ventricular pseudoaneurysm has been a topic of discussion since the pioneering days of open heart surgery, it still remains a technical challenge in reconstructive cardiac surgery. Reoperation following pseudoaneurysm repair is also frequent. We report ...
Rodrigues Fernando - - 2014
It has been suggested that exercise training (ET) protects against the pathological remodeling and ventricular dysfunction induced by myocardial infarction (MI). However, it remains unclear whether the positive adjustments on baroreflex and cardiac autonomic modulations promoted by ET may afford a cardioprotective mechanism. The aim of this study was to ...
Ryckman Eva M EM Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI, 53792-3252, - - 2014
The purpose of this study was to determine if quantifying visceral adipose tissue (VAT) at CT in asymptomatic adults can predict the likelihood of future cardiac events. Subcutaneous and visceral fat volumes were obtained from abdominal CT utilizing a validated semi-automated software tool in 663 asymptomatic adults (mean age 57.3 years, ...
Yang Kai-Chien KC Lifespan Cardiovascular Research Center, the Warren Alpert School of Medicine, Brown University & Providence Veterans Administration Medical Center, Providence, RI & Department of Medicine, University of Illinois at Chicago, Chicago, - - 2014
-Genome wide association studies (GWAS) have revealed significant association of caveolin-1 (Cav1) gene variants with increased risk of cardiac arrhythmias. Nevertheless, the mechanism for this linkage is unclear. -Using adult Cav1(-/-) mice, we revealed a marked reduction in the left ventricular (LV) conduction velocity in the absence of myocardial Cav1, ...
Stárek Zdeněk Z 1st Department of Internal Medicine - Cardioangiology St. Anne's University Hospital Brno Pekarska 53 656 91 Brno Czech Republic. - - 2014
Atrial fibrillation is the most common sustained arrhythmia. Because of the sub-optimal outcomes and associated risks of medical therapy as well as the recent advances in non-pharmacologic strategies, a multitude of combined (hybrid) algorithms have been introduced that improve efficacy of standalone therapies while maintaining a high safety profile. Antiarrhythmic ...
Dietl Alexander A Department of Internal Medicine II, University Hospital Regensburg; Department of Genetic Epidemiology, University of - - 2014
Left and right atria show compelling differences regarding organogenesis and specific clinical diseases. In congestive heart failure (CHF), remodelling of the atria occurs leading to increased arrhythmogenic susceptibility and deterioration of clinical symptoms. We aimed to assess the basal left and right atrial molecular set-up and different chamber-specific atrial changes ...
Peng Hongmei H Henry Ford - - 2014
Thymosin β4 (Tβ4) promotes cell survival, angiogenesis, tissue regeneration and reduces inflammation. Cardiac rupture after myocardial infarction (MI) is mainly the consequence of excessive regional inflammation, whereas cardiac dysfunction after MI results from a massive cardiomyocyte loss and cardiac fibrosis. It is possible that Tβ4 reduces incidence of cardiac rupture ...
Conover Zacherie Z Sarver Heart Center, University of Arizona College of Medicine, Tucson, - - 2014
-Prior investigation of out-of-hospital cardiac arrest (OHCA) has raised the concern that ventricular fibrillation (VF) recurrence may be triggered by chest compression (CC) resumption. We investigated predictors of VF recurrence after defibrillation, including timing of CC resumption. -Patients with witnessed OHCA and initial rhythm of VF from an Utstein-style database ...
Picchi Andrea A aDepartment of Cardiology, Misericordia Hospital, Grosseto bDepartment of Medical and Surgical Critical Care, University of Florence, Florence, - - 2014
Therapeutic hypothermia has demonstrated to improve both survival and neurological outcome in patients who experienced an out-of-hospital cardiac arrest. Nevertheless, many aspects of its clinical application are still controversial. Current guidelines recommend to cool patients who survive a cardiac arrest due to either ventricular fibrillation or ventricular tachycardia, whereas the ...
Nardi Paolo P Cardiac Surgery Unit, Policlinico Tor Vergata, Tor Vergata University of Rome, Rome, - - 2014
To evaluate the fate of on-pump coronary artery bypass grafting (ON-pump CABG) vs. off-pump coronary artery bypass grafting (OP-CABG) surgery at mid-term follow-up. From January 2008 to December 2010, 369 patients underwent surgical myocardial revascularization by means of OP-CABG techniques (n = 166) or with ON-pump CABG (n = 203). ...
Carlomagno Guido G aDepartment of Cardiology, Monaldi Hospital, AORN Ospedali dei Colli bDepartment of Translational Medical Sciences, Federico II University cUnit of Cardiology, Loreto Mare Hospital dSecond University of Naples, Monaldi Hospital, AORN Ospedali dei Colli, Naples, - - 2014
Intraventricular dyssynchrony has traditionally been studied by means of contraction delays between different myocardial segments. Recently, the discoordination of opposing wall contraction throughout the cardiac cycle has been proposed as a more faithful predictor of response. Aim of the current study was to evaluate which parameters - mechanical dyssynchrony or ...
Lomivorotov Vladimir V VV Departments of Anaesthesiology and Intensive Care. Electronic address: - - 2014
To test the hypothesis that perioperative OMEGA-3 polyunsaturated fatty acid infusion would reduce the incidence of postoperative atrial fibrillation in patients after coronary artery bypass grafting as assessed by an implantable continuous cardiac monitor. Prospective, randomized, double-blind, placebo-controlled study. Tertiary cardiothoracic referral center. Thirty-nine patients with coronary artery disease who ...
Ozsu Savas S Pulmonary Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon, - - 2014
Soluble urokinase plasminogen activator receptor (suPAR) is a newly discovered inflammatory biomarker. suPAR has not been previously studied in differentiating non-cardiac pleural effusion from cardiac pleural effusions. The aim of our study was to assess the diagnostic value of suPAR in pleural effusion (PF). The concentration of PF suPAR was ...
Kim Jiwon J Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, - - 2014
Left ventricular (LV) remodeling and myocardial fibrosis have been linked to adverse heart failure outcomes. Mid wall late gadolinium enhancement (MW-LGE) on cardiac magnetic resonance (CMR) imaging is well-associated with non-ischemic cardiomyopathy (NICM), but prevalence in ischemic cardiomyopathy (ICM) and association with remodeling are unknown. The population comprised patients with ...
Akat Kemal Marc KM Laboratory of RNA Molecular Biology,Howard Hughes Medical Institute, The Rockefeller University, New York, NY - - 2014
Heart failure (HF) is associated with high morbidity and mortality and its incidence is increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic and therapeutic applications, respectively. We determined myocardial and circulating miRNA abundance and its changes in patients with stable and end-stage HF before and at different ...
Pozo Eduardo E The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, New York, USA Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, Madrid, - - 2014
Cardiac amyloidosis (CA) is associated with typical morphological features on echocardiography, including concentric LV hypertrophy (LVH). Cardiac magnetic resonance (CMR) can accurately depict anatomy in different cardiomyopathies. Our aim was to describe the morphological features and remodelling patterns of CA with CMR, and establish their diagnostic accuracy, as well as ...
Senel Ayaz H Gözde HG Drexel University, School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA 19104, USA. Electronic address: - - 2014
For patients with end-stage heart disease, the access to heart transplantation is limited due to the shortage of donor organs and to the potential for rejection of the donated organ. Therefore, current studies focus on bioengineering approaches for creating biomimetic cardiac patches that will assist in restoring cardiac function, by ...
Abdoli Abas A Department of Mechanical and Materials Engineering, MAIDROC Laboratory, Florida International University, Miami, FL, 33174, USA. - - 2014
The main objective of this work was to demonstrate computationally that realistic human hearts can be cooled much faster by performing conjugate heat transfer consisting of pumping a cold liquid through the cardiac chambers and major veins while keeping the heart submerged in cold gelatin filling a cooling container. The ...
Burrell Lance D LD Intermountain Heart Institute, Intermountain Medical Center, Murray, - - 2014
We report the successful biopsy of a right atrial fatty mass using CARTO 3-dimensional electro-anatomic mapping fused with cardiac MRI. Fluoroscopic guidance within the cardiac chambers lacks precision and therefore risks geographical miss of the intended target and cardiac perforation. CARTO mapping fused with cardiac MRI facilitated precise navigation of ...
Goodwill Adam G AG Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN, 46202-5111, USA, - - 2014
This study examined the cardiovascular effects of GLP-1 (7-36) or (9-36) on myocardial oxygen consumption, function and systemic hemodynamics in vivo during normal perfusion and during acute, regional myocardial ischemia. Lean Ossabaw swine received systemic infusions of saline vehicle or GLP-1 (7-36 or 9-36) at 1.5, 3.0, and 10.0 pmol/kg/min in ...
Borisenko Oleg O From *Synergus AB, Danderyd, Sweden; †Scottish Extracorporeal Life Support Service, Royal Hospital for Sick Children, Glasgow, the United Kingdom; ‡ Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Clydebank, the United Kingdom; §Synergus AB, Danderyd, and Medical Management Centre, Department of Learning Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; ¶Paediatric and Neonatal ECMO Service, Freeman Hospital, Newcastle upon Tyne, the United Kingdom; & Department of Cardiothoracic Transplant, Wythenshawe Hospital, Manchester, the United Kingdom; and #Emeritus Cardiothoracic Surgeon, Glenfield General Hospital, Leicester, the United - - 2014
The aim of the study was to systematically evaluate effect of CentriMag heart pump (Thoratec Corporation, Pleasanton, CA, USA) as temporary ventricular assist device (VAD) and part of extra corporeal membrane oxygenation (ECMO) system on outcomes in patients with cardiac or cardiac-respiratory failure. A systematic search was conducted in five ...
Smigla G G Duke Children's Hospital, Duke University Hospital, Durham, NC, USA - - 2014
del Nido cardioplegia solution (CPS) has been successfully used for myocardial protection in the pediatric population. We propose this solution can be used safely in adult congenital patients. The proposed benefit of this solution is the avoidance of the need for repetitive interruption of the operation to administer multiple doses ...
Grans Camilla Figueiredo CF Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, - - 2014
Background: Although resistance exercise training is part of cardiovascular rehabilitation programs, little is known about its role on the cardiac and autonomic function after myocardial infarction. Objective: To evaluate the effects of resistance exercise training, started early after myocardial infarction, on cardiac function, hemodynamic profile, and autonomic modulation in rats. ...
Depta J P JP Washington University School of Medicine, Department of Medicine, St Louis, MO, - - 2014
We examined clinical outcomes with proton pump inhibitors (PPI) use within CYP2C19 genotype groups during clopidogrel treatment following acute myocardial infarction (AMI). 2062 patients were genotyped for CYP2C19*2 and *17 variants in TRIUMPH. 12 month clinical outcomes were analyzed among patients discharged on clopidogrel within CYP2C19*2 carrier, CYP2C19*17 carrier, and ...
Legutko Jacek J Department of Interventional Cardiology, University Hospital, Krakow. - - 2014
The growing penetration of mechanical reperfusion in ST-elevation myocardial infarction (STEMI) has been achieved by creation of new percutaneous coronary intervention (PCI) centers which helped shorten time delays but compromised PCI volume. To compare outcomes in STEMI patient treated in PCI centers with or without surgical back-up. Data concerning 1650 ...
Truong Quynh A QA Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, New York; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
A significant minority of patients receiving cardiac resynchronization therapy (CRT) remain non-responsive to this intervention. To determine whether coronary sinus (CS) or baseline peripheral venous (PV) levels of established and emerging heart failure (HF) biomarkers are predictive of CRT outcomes. In 73 patients (age 68±12; 83% male; ejection fraction 27±7%) ...
Iyer A A The Victor Chang Cardiac Research Institute, Sydney, Australia; Heart and Lung Transplant Unit, St. Vincent's Hospital, Darlinghurst, Australia; Department of Cardiothoracic Surgery, St. Vincent's Hospital, Darlinghurst, - - 2014
Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts. We used a porcine asphyxia model to evaluate viability of DCD hearts subjected to warm ischemic times (WIT) of 20-40 min prior to flushing with Celsior (C) solution. We then assessed potential benefits of supplementing C with erythropoietin, ...
Banshodani Masataka M Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital 3-30, Nakajimacho, Naka-ku, Hiroshima - - - 2014
Increased vascular access flow after percutaneous transluminal angioplasty (PTA) for central venous stenosis and occlusion (central venous disease, CVD) can affect cardiac function in hemodialysis (HD) patients. We evaluated the cardiac function, etiology, and treatment in HD patients with CVD. HD patients with CVD treated by PTA between June 2006 ...
Lima Aline Regina Ruiz AR Internal Medicine Department, Botucatu Medical School - UNESP, Botucatu, SP, - - 2014
Background: Intracellular signaling pathways involved in skeletal myosin heavy chain (MyHC) isoform alterations during heart failure (HF) are not completely understood. We tested the hypothesis that diaphragm expression of mitogen-activated protein kinases (MAPK) and myogenic regulatory factors is changed in rats with myocardial infarction (MI) induced HF. Methods: Six months ...
Udink Ten Cate Floris E A FE Department of Pediatric Cardiology, Heart Center Cologne, University Hospital of Cologne, Cologne, Germany. Electronic address: - - 2014
The 12-lead surface electrocardiogram is a valuable and feasible clinical tool in the management of patients following tetralogy of Fallot (TOF) repair. The importance of QRS duration in TOF patients has long been acknowledged. A prolonged QRS complex has been associated with increased risk for subsequent life-threatening ventricular arrhythmia and ...
Börekçi Abdurrezzak A aDepartment of Cardiology, School of Medicine, Kafkas University, Kars bDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana cDepartment of Internal Medicine, Mersin State Hospital, Mersin, - - 2014
Epicardial adipose tissue is related to coronary atherosclerosis, left ventricle hypertrophy, myocardial dysfunction, cardiomyopathy, and inflammation, which produces a variety of cytokines that influence key pathogenic mechanisms of atherogenesis. The main goal of this study is to examine the relationship between epicardial fat thickness (EFT) and cardiovascular risk markers as ...
Baruteau J J Metabolic Medicine Department, Great Ormond Street Hospital, London, UK. Electronic address: - - 2014
Dilated cardiomyopathy is a rare complication in propionic acidaemia (PA). Underlying pathophysiological mechanisms are poorly understood. We present a child of Pakistani consanguineous parents, diagnosed with late-onset PA at 18months of age. He presented a mild phenotype, showed no severe further decompensations, normal growth and psychomotor development on a low ...
Yang Xin-Wei XW Center of Arrhythmia Diagnosis and Treatment, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
Fragmented QRS (fQRS) marks inhomogeneous activation and asynchronous cardiac contraction. It has been proved that cardiac resynchronization therapy (CRT) could reverse geometrical remodeling as well as correct electrical dyssynchrony. We aimed to investigate whether fQRS changed corresponding to the therapeutic response to CRT. Patients who underwent de novo CRT implantation ...
Martinez Sara C SC Cardiovascular Division, Department of Internal Medicine, School of Medicine, Washington University, Saint Louis, - - 2014
Electrocardiograms (ECGs) are routinely obtained in patients with advanced congestive heart failure (CHF) before and after surgical implantation with a left-ventricular assist device (LVAD). As the number of patients with CHF is increasing, it is necessary to characterize the changes present in the ECG of patients with LVADs. ECGs of ...
Celikyurt Umut U Department of Cardiology, Kocaeli University Medical Faculty, Kocaeli, - - 2014
Cardiac resynchronization therapy (CRT) has been recommended for patients with symptomatic heart failure and a wide QRS. Fragmented QRS (fQRS) on a 12-lead electrocardiography (ECG) has been shown to predict cardiac events. We aimed to investigate the relationship between resolution of fQRS and response to CRT. Sixty-seven consecutive patients (38 ...
Sano Makoto M Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, - - 2014
Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, ...
Mochizuki Yasuhide Y Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of - - 2014
Background:Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to the patient's response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, are also influential.Methods and Results:We studied 132 patients undergoing CRT. LV dyssynchrony was determined by anteroseptal-to-posterior wall delay on the mid-LV short-axis view using ...
Quatre A A Department of internal medicine, North Hospital, chemin des Bourrely, 13015 Marseille, France. Electronic address: - - 2014
We report the results of combining cardiac and hepatic MRI in the same examination to monitor 48 multi-transfused patients presenting iron overload secondary to their transfusions. This cardiac MRI technique uses acquisition sequences and calculation software that are readily available for 1.5 T systems, and it has been validated to ...
Metelka Rudolf R Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech - - 2014
Backround. The autonomic nervous system is one of the major homeostatic regulatory systems of the body. Detection of cardiac autonomic neuropathy (CAN), reflected by reduced heart rate variability (HRV), is an independent adverse prognostic factor: sympathovagal balance failure with a sympathetic dominance is the main trigger for lethal arrhythmias and ...
1 2 3 4 5 6 7 8 9 10 >