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Amaki Makoto M Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, - - 2014
-Variations in longitudinal deformation of the left ventricle (LV) have been suggested to be useful for differentiating chronic constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM). We assessed LV mechanics derived from cardiac magnetic resonance (CMR) cine-based and two-dimensional (2D) echocardiography-based tissue-tracking to determine inter-modality consistency of diagnostic information for differentiating ...
Fatullayev Javid J Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, UB9 6JH, UK, - - 2014
In this case report, we describe a 66-year-old patient with a massive LV aneurism which resulted after myocardial infarction. Due to severe LV function impairment, it was decided to perform left ventricular reconstruction surgery and, at the same time, left ventricular assist device implantation as a bridge to transplantation. The ...
Rastogi Abhinav A Department of Pediatric Critical Care, Fortis Escorts Heart Institute, New Delhi, India. Correspondence to: Dr Abhinav Rastogi, Pediatric Critical Care Department, Fortis Escorts Heart Institute, Okhla, New Delhi 110 025, India. - - 2014
The management of ventricular electrical storm can prove to be a challenge for the clinician given its complexity and life threatening consequences. 8-year-old boy with repeated life-threatening polymorphic ventricular tachycardia following aortic valve replacement surgery. Defibrillated 45 times in addition to multiple antiarrhythmic drugs. Conversion to stable sinus rhythm with ...
Kofidis Theo T Department of Surgery, National University of Singapore, Singapore, Singapore; Department of Cardiothoracic and Vascular Surgery, National University Health System, Singapore, - - 2014
We introduced a cardioscopic surgical platform for a wide range of cardiac procedures, to address various intracardiac pathologies, through the left ventricular (LV) apex on the arrested heart. The method involves endoscopic access into the LV cavity; hence the term "transapical cardioscopic surgery (TACS)." For this proof-of-concept study, we obtained ...
Philipp Melanie M Ulm University, Germany; - - 2014
G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5) are fundamental regulators of cardiac performance in adults, but are less well characterized for their function in the hearts of embryos. GRK2 and 5 belong to different subfamilies and function as competitors in the control of certain receptors and signaling pathways. ...
Mu WenLi W State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, - - 2014
SIRT1, a mammalian ortholog of yeast silent information regulator 2 (Sir2), is an NAD(+)-dependent protein deacetylase that plays a critical role in the regulation of vascular function. The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart. Here we show that the early postnatal ...
Fabregat-Andrés Oscar O Cardiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain Research Foundation, Hospital General Universitario, Valencia, Spain - - 2014
Pulmonary arterial hypertension is known to be related to worse prognosis in patients with heart failure (HF). Quantification of pulmonary vascular resistance (PVR) still requires invasive right heart catheterization. Recent studies have shown an accurate method for non-invasive estimation of PVR by cardiac magnetic resonance (CMR). Our aim was to ...
Gupta Punkaj P Division of Pediatric Critical Care; Division of Pediatric Cardiology. Electronic address: - - 2014
To describe epidemiology and outcomes associated with cardiac arrest among critically ill children across hospitals of varying center volumes. Patients <18 years of age in the Virtual PICU Systems (VPS, LLC) Database (2009-2013) were included. Patients with both cardiac and non-cardiac diagnoses were included. Data on demographics, patient diagnosis, cardiac ...
Bergonzini S S Department of Cardiology, Azienda Ospedaliera Santa Maria, University of Perugia, via Tristano di Joannuccio s/n, 05100, Terni, Italy, - - 2014
Hypoplastic left heart syndrome is a spectrum of structural cardiac malformations characterized by variable underdevelopment of the left heart-aorta complex. A minority of patients having a milder degree of left ventricular hypoplasia, described as hypoplastic left heart complex (HLHC), may be selected for biventricular repair. The objective of this study ...
Numan Mohammed T MT University of Texas, Houston, TX, USA, - - 2014
Ibn Al Nafis, born 1213, was the first to discover the "circulation lesser" and describe the blood flow from the right ventricle to the lungs then back to the left ventricle 300 years before William Harvey. He bravely rejected the theory of Galen (130-200 AD) and Avicenna (980-1037 AD) which ...
Amoozgar Hamid H Cardiac Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, - - 2014
Transcatheter closure of atrial septal defect (ASD) is the most common approach to close the defects worldwide. In this approach, persistent conduction disturbance is extremely rare, but an acute increase in supraventricular ectopy and minimal risk of atrioventricular conduction disturbance, as complete heart block, has been seen. Here, we report ...
Kawase Yoshiaki Y Department of Cardiovascular Medicine, Gifu Heart Center, 4-14-4 Yabutaminami, Gifu City, Gifu, 500-8384, Japan, - - 2014
An 80-year-old male patient underwent a coronary angioplasty without signs of complications. The day after the procedure, the patient complained of chest pain. The electrocardiogram showed a widespread ST segment elevation. A chest X-ray revealed pulmonary congestion with pleural effusion. There was no significant pericardial effusion detected with an echocardiogram. ...
Kalogirou Stamatia S Developmental Biology, Biomedical Research Foundation Academy of Athens, - - 2014
Valvular heart disease is responsible for considerable morbidity and mortality. Cardiac valves develop as the heart contracts, and they function throughout the lifetime of the organism to prevent retrograde blood flow. Their precise morphogenesis is crucial for cardiac function. Zebrafish is an ideal model to investigate cardiac valve development as ...
Rafatian Naimeh N University of Ottawa Heart - - 2014
After myocardial-infarction (MI) inflammation and apoptosis contribute to progressive cardiac remodeling and dysfunction. Cardiac mineralocorticoid-receptor (MR) and β-adrenergic signaling promote apoptosis and inflammation. Post MI, MR activation in the brain contributes to sympathetic hyperactivity and an increase in cardiac aldosterone. In the present study we assessed the time-course of macrophage ...
Shi Dan D Key Laboratory of Basic Research in Cardiology of the Ministry of Education of China, Tongji University, Shanghai, China; Institute of Medical Genetics, Tongji University, Shanghai, - - 2014
Ischaemic cardiac arrhythmias cause a large proportion of sudden cardiac deaths worldwide. The ischaemic arrhythmogenesis is primarily because of the dysfunction and adverse remodelling of sarcolemma ion channels. However, the potential regulators of sarcolemma ion channel turnover and function in ischaemic cardiac arrhythmias remains unknown. Our previous studies indicate that ...
Germano Giuseppe G Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza University of Rome, Rome, Italy, - - 2014
Overweight and obesity are estimated at high prevalence and progression in adults; they are major contributors to chronic diseases and a major public health challenge. An obese habitus changes body-surface electrocardiograms (ECGs). Obesity is responsible for geometric changes to the heart and torso, as well as for deleterious electrophysiological changes ...
Arakawa Junko J Department of Cardiology, Japan Self-Defense Forces Central Hospital, Ikejiri 1-2-24, Setagaya-ku, Tokyo, 154-8532, Japan, - - 2014
Sudden cardiac death (SCD) in athletes <35 years of age are mostly due to congenital or acquired cardiac malformations or hypertrophic cardiomyopathy. However, ion channelopathies such as catecholaminergic polymorphic ventricular tachycardia (CPVT) or long-QT syndromes, which are less frequently observed, are also potential pathogenesis of SCD in young athletes. CPVT is ...
Sharkey Scott W SW Minneapolis Heart Institute Foundation at Abbott Northwestern - - 2014
First described in Japan over 2 decades ago, takotsubo cardiomyopathy (TTC) has emerged as a unique cardiomyopathy with world-wide recognition, mimicking acute coronary syndrome. In early TTC experience, typical patients were older women, with a triggering emotional event, ST-segment elevation, and apical ballooning left ventricular (LV) contraction pattern. However, TTC ...
Friedman Daniel J DJ Division of Cardiology, Duke University Hospital, Durham, NC, - - 2014
Cardiac Resynchronization Therapy (CRT) non-responders have poor outcomes. The significance of progressive ventricular dysfunction among non-responders remains unclear. We sought to define predictors of and clinical outcomes associated with progressive ventricular dysfunction despite CRT. We conducted an analysis of 328 patients undergoing CRT with defibrillator for standard indications. Based on ...
Palti Yoram Y B. Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel; EchoSense Ltd., Haifa, - - 2014
To determine the diagnostic information contained in cardiac pulsatile pressure waves as expressed in the Doppler signals recorded over the right lung. The pulsatile characteristics of the pulmonary vascular system were studied by means of the novel pulse Doppler technology in 38 control volunteers, 31 patients with atrial fibrillation (AF) ...
Guo Ang A Division of Cardiovascular Medicine, Department of Internal Medicine, and Francois M. Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA - - 2014
Heart failure is accompanied by a loss of the orderly disposition of transverse (T)-tubules and a decrease of their associations with the junctional sarcoplasmic reticulum (jSR). Junctophilin-2 (JP2) is a structural protein responsible for jSR/T-tubule docking. Animal models of cardiac stresses demonstrate that down-regulation of JP2 contributes to T-tubule disorganization, ...
Niemeijer Maartje N MN Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The - - 2014
Sudden cardiac death (SCD) is a major health burden and is primarily caused by ventricular arrhythmias. Currently, the most well-known marker for the risk of ventricular arrhythmias is QT/QTc prolongation. Animal studies indicate that QT variability might be a better indicator. Our objective was to give an overview of the ...
DO VAN Buu Dan VB Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang Ming University Hospital, Taipei, - - 2014
A 44-year-old man with structurally normal heart underwent catheter ablation of left ventricular summit tachycardia. The initial mapping revealed the origin of tachycardia at the junction of great cardiac vein and anterior interventricular vein. During ablation the exit site shifted to the nearby regions, which was recognized by subtle changes ...
Hochholzer Willibald W Universitaets-Herzzentrum Freiburg·Bad Krozingen, Klinik für Kardiologie und Angiologie II, Suedring 15, 79189 Bad Krozingen, Germany. Electronic address: - - 2014
In stable patients with unknown coronary anatomy, higher levels of cardiac troponin are associated with an increased risk of cardiovascular events. It was supposed that this association might be explained by the ability of cardiac troponin to detect minor myocardial necrosis which might be caused by subclinical coronary atherosclerosis. Thus, ...
Lindner Diana D Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Martinistr. 52, 20246, Hamburg, Germany, - - 2014
Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with outcome in patients. However, the basis for the development of both remains unclear. We have previously reported that cardiac inflammation triggers transdifferentiation of fibroblasts to myofibroblasts and therefore increase accumulation of cardiac collagen, one key pathology in cardiac ...
Huang Ying Y Department of Oncology and nursing, Shanghai Pulmonary Hospital of Tongji University, 507 Zhengmin Rd, Yangpu, Shanghai, 200433, - - 2014
Cellular FLICE-like inhibitory protein (Flip) is a negative regulator of nuclear factor κB signaling which has been shown previously to complicate with cardiac hypertrophy. In the present study, we tested the hypothesis that the knockout of Flip would increase cardiac hypertrophy in vivo and in vitro. The effects of Flip ...
Scott John P JP Section of Pediatric Anesthesia, Department of Anesthesiology, Medical College of Wisconsin, 9000 W. Wisconsin Ave, Milwaukee, WI, 53201, - - 2014
Historically, droperidol was commonly used for postoperative sedation of critically ill children. A FDA black box warning regarding its arrhythmogenic potential greatly reduced its use. We hypothesized that administration of neuroleptic dose droperidol during volatile anesthesia would transiently prolong the corrected QT interval (QTc) in patients undergoing single ventricle palliation. ...
Wohlmuth C C Division of Pediatric Cardiology, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, - - 2014
The atria of the heart function as reservoir, conduit, and active pump and are critical for ventricular filling and cardiac output. We sought to evaluate right (RA) and left atrial (LA) function in patients after tetralogy of Fallot (TOF) repair by using cardiovascular magnetic resonance. Twelve TOF patients, age 16.7 ± 6.1 years, ...
Shinlapawittayatorn Krekwit K Cardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address: - - 2014
We previously reported that vagus nerve stimulation (VNS) applied immediately at the onset of cardiac ischemia provides cardioprotection against cardiac ischemia-reperfusion (I/R) injury. To determine whether VNS applied later during ischemia or at the onset of reperfusion exerts differential cardioprotection against cardiac I/R injury. Twenty-eight swine (25-30 kg) were randomized ...
Nakahashi Takuya T Division of Cardiology, Kokura Memorial Hospital, Kitakyusyu, - - 2014
Although patients with immunoglobulin light chain (AL) cardiac amyloidosis exhibit worse outcomes than those with transthyretin (TTR) cardiac amyloidosis, few data exist regarding the occurrence of cardiac events and the echocardiographic indices in endomyocardial biopsy (EMBx) proven amyloidosis. From November 2007 to October 2012, we identified 33 patients with EMBx-proven ...
Thériault-Lauzier Pascal P Department of Medicine, Division of Cardiology, McGill University Health Centre, Montreal, Quebec, - - 2014
With the introduction of transcatheter structural heart therapies, cardiologists are increasingly aware of the importance of understanding anatomical details of left-sided heart structures. Understanding fluoroscopic cardiac anatomy can facilitate optimal positioning and deployment of prostheses during transcatheter valve repair/replacement, left atrial appendage occlusion, septal defect closure, and paravalvular leak closure. ...
Gillespie H Sawyer HS Division of Cardiology, University of Washington, 1959 NE Pacific Street, Box 356422, Seattle, WA, 98195, - - 2014
The presence of structural heart disease is often associated with the development of electrical abnormalities of the heart, manifesting as atrial and ventricular arrhythmias. These can occur in those with ischemic and nonischemic cardiomyopathies, congenital heart disease, and various acquired and intrinsic structural abnormalities of the myocardium. Treatment of these ...
Akoum Nazem N Comprehensive Arrhythmia Research and Management (CARMA) Center, Division of Cardiovascular Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT, 84132, USA, - - 2014
Fibrosis is an essential component of structural remodeling that accompanies different cardiovascular disease conditions. In cardiac arrhythmias, fibrosis plays an important role in creating the necessary substrate for these arrhythmias to persist. Non-invasive evaluation of the arrhythmia substrate has seen significant advancements in the past several years. Cardiac MRI characterizes ...
Zipse Matthew M MM Division of Cardiology, Section of Cardiac Electrophysiology, University of Colorado, Denver, CO, USA, - - 2014
Cardiac sarcoidosis (CS) is a rare and under-recognized clinical entity that requires a high level of suspicion and low threshold for screening in order to make the diagnosis. CS may manifest in a variety of ways, and its initial presentation can range from asymptomatic electrocardiographic abnormalities to overt heart failure ...
Dai Yuxiang Y Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, Japan ; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. - - 2014
The present study compared short- and long-term prognostic values of red blood cell distribution width (RDW) with those of hemoglobin (Hgb) among patients with acute congestive heart failure (CHF) in a cardiac care unit. The cross-sectional study examined data from 521 patients with acute CHF who were admitted to a ...
Groeneweg J A JA Department of Cardiology, University Medical Center Utrecht, HP Q05.2.314, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, the Netherlands, - - 2014
Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is a hereditary disease characterised by ventricular arrhythmias, right ventricular and/or left ventricular dysfunction, and fibrofatty replacement of cardiomyocytes. Patients with AC typically present between the second and the fourth decade of life with ventricular tachycardias. However, sudden cardiac ...
Abdelmoneim Sahar S SS Mayo Clinic Cardiovascular Ultrasound Imaging and Hemodynamic Laboratory, Division of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota USA (S.S.A., P.A.P., S.L.M.); and Division of Cardiovascular Medicine, Assiut University, Assiut, Egypt - - 2014
The diagnosis of intracardiac thrombi remains clinically relevant, with associated risks of systemic embolization and implications for antithrombotic management. Intravenously injected ultrasound contrast agents, composed of microbubbles smaller than red blood cells, have become established essential adjunctive tools for performance of state-of-the-art echocardiography, providing important information on cardiac structure and ...
Kennedy Maureen Shawn MS AJN Editor-in-Chief E-mail: - - 2014
The transformative power of relationship building.
Golob Mark M Department of Biomedical Engineering, UW-Madison College of Engineering, 2146 Engineering Centers Building, 1550 Engineering Drive, Madison, WI, 53706, - - 2014
From an engineering perspective, many forms of heart disease can be thought of as a reduction in biomaterial performance, in which the biomaterial is the tissue comprising the ventricular wall. In materials science, the structure and properties of a material are recognized to be interconnected with performance. In addition, for ...
Ren Lan L Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of - - 2014
Ventricular arrhythmias (VA) arising from arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and idiopathic right ventricular outflow tract ventricular arrhythmias (RVOT-VA) share the pattern of left bundle branch block (LBBB)/inferior axis. The existence of QRS notching showed a discriminating effect of the two conditions in recent research; however, there are little data ...
Momtahan Nima N Brigham Young University, Chemical Engineering, Provo, Utah, United States ; - - 2014
Heart failure is one of the leading causes of death in the United States. Current therapies such as heart transplants and bioartificial hearts are helpful, but not optimal. Decellularization of porcine whole hearts followed by recellularization with patient-specific human cells may provide the ultimate solution for patients with heart failure. ...
Buckberg Gerald D GD Department of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA - - 2014
The heart's structure-function relationships explain normal cardiac dynamics and clarify how they are disrupted by disease. For 500 years, anatomists described circumferential and helical cardiac fibres, yet disagreed about their relationships. One current model is attributed to Torrent Guasp who described functional pathways, the helical ventricular myocardial band (HVMB) with ...
Lambiase Pier D PD The Heart Hospital, University College Hospital & Institute of Cardiovascular Sciences, UCL, 16-18 Westmoreland Street, London, W1G 8PH, UK, - - 2014
The Subcutaneous Internal Cardiac Defibrillator (S-ICD) represents a major advance in the care of patients who have an indication for an internal cardiac defibrillator without pacing indications. Its main advantage is that it can deliver a shock to cardiovert ventricular arrhythmias utilising a tunnelled subcutaneous lead, negating the risks associated ...
Nakajima Hiroyuki H Department of Cardiovascular Surgery, Saitama International Medical Center, Saitama Medical University, Saitama, Japan. Electronic address: - - 2014
A 63-year-old man presented with sudden cardiac shock due to cardiac rupture after a blunt chest trauma. We emergently repaired 2 rupture sites with the sandwich technique. This technique maintained the ventricular geometry, and minimized impairment of cardiac function.
Petri Helle - - 2014
BackgroundMyotonic dystrophy type 1 (DM1) is associated with increased cardiac morbidity and mortality. Therefore, assessment of cardiac involvement and risk stratification for sudden cardiac death is crucial. Nevertheless, optimal screening-procedures are not clearly defined. ECG, echocardiography and Holter-monitoring are useful but insufficient. Cardiovascular magnetic resonance (CMR) can provide additional information ...
Sattur Sudhakar S Robert Packer Hospital & Guthrie Health Systems, 1 Guthrie Square, Sayre PA 18840 USA. - - 2014
The use of transradial access for cardiac catheterization and percutaneous coronary intervention (PCI) has increased substantially in recent years. However, the transradial approach may not be feasible in certain patients. Although the transulnar approach can serve as an alternative approach in these subjects, it is infrequently used. We performed a ...
Quattrini Filippo M FM Institute of Sport Medicine and Science, Italian National Olympic Committee. Rome, - - 2014
J-wave/QRS slurring (early repolarization) on 12-lead ECG has been associated with increased risk for ventricular fibrillation in the absence of cardiovascular (CV) disease. We assessed the prevalence and clinical significance of J-wave/QRS slurring in a large population of competitive athletes. 704 athletes, free of CV disease, 436 males (62%), aged ...
Agrawal Shilpa S David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, - - 2014
Cardiac Syndrome X (CSX), characterized by angina-like chest discomfort, ST segment depression during exercise, and normal epicardial coronary arteries at angiography, is highly prevalent in women. CSX is not benign, and linked to adverse cardiovascular outcomes and a poor quality of life. Coronary microvascular and endothelial dysfunction and abnormal cardiac ...
Vukovic Petar M PM Departments of Cardiac Surgery (Drs. Micovic, Milicic, Stojanovic, and Vukovic) and Cardiology (Drs. Jovovic and Kosevic), Dedinje Cardiovascular Institute, 11040 Belgrade, - - 2014
Cor triatriatum dexter is a rare congenital heart anomaly in which a membrane divides the right atrium into 2 chambers. We report the case of a 43-year-old woman who had cor triatriatum dexter and a large atrial septal defect. During attempted percutaneous closure, the balloon disrupted the membrane and revealed ...
Garcia-Morales Luis J LJ Department of Cardiovascular Surgery, Methodist DeBakey Heart & Vascular Center, Houston, Texas - - 2014
Bleeding can occur as a sequela to cardiac surgery. Surgical products-such as conventional sutures and clips, and somewhat less conventional sealants-have been developed to prevent this event. Among these, CoSeal is a sealant used at our institution; here we report the cases of 2 patients in whom CoSeal was used ...
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