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Neunhäuserer Daniel D 1Sports Medicine Division, Department of Medicine - University of Padova, Padova, Italy; 2University Institute for Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Salzburg, Austria; 3Cardiac Magnetic Resonance Unit, Euganea Medica, Albignasego, Padova, - - 2014
Myocardial crypts are extensions of blood signal penetrating the compact myocardium and are considered in literature as either a distinctive cardiac magnetic resonance (CMR) imaging marker for hypertrophic cardiomyopathy or as benign congenital malformations. What if CMR reveals a myocardial crypt in the presence of an altered ECG in an ...
Fraccarollo Daniela D Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30175, Hannover, - - 2014
Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether stimulating the NO/heme-independent sGC provides additional ...
van Rijsingen Ingrid A W IA Department of Cardiology, Academic Medical Center, Amsterdam, the - - 2014
-The pathogenic phospholamban (PLN) R14del mutation causes dilated and/or arrhythmogenic right ventricular cardiomyopathies and is associated with an increased risk of malignant ventricular arrhythmias and end-stage heart failure. We performed a multicentre study to evaluate mortality, cardiac disease outcome, and risk factors for malignant ventricular arrhythmias in a cohort of ...
Hong Jueun J Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul 120-752, Republic of Korea; Korea Testing & Research Institue (KTR), 155 Beodeunaru-ro, Yeongdeungpo-gu, Seoul 150-038, Republic of - - 2014
Inflammatory response in myocardial ischemia-reperfusion injury plays a critical role in ventricular remodeling. To avoid deleterious effects of overwhelming inflammation, we blocked the expression of receptor for advanced glycation end-products (RAGE), a key mediator of the local and systemic inflammatory responses, via RNAi mechanism. Herein, a facial amphipathic deoxycholic acid-modified ...
Braggion-Santos Maria Fernanda MF Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg 69120, Germany School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, - - 2014
Cardiac allograft vasculopathy (CAV), which limits long-term survival after heart transplantation (HTX), is usually evaluated by coronary angiography (CA). Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) is a non-invasive technique that can detect CAV-related myocardial infarctions. We aimed to investigate the presence of LGE infarct-typical patterns in a large sample ...
Wilson W M WM Edinburgh Heart Centre, Edinburgh, Scotland, United - - 2014
This case illustrates a potential complication of the retrograde approach using epicardial collaterals for chronic total occlusion PCI. Hypotension post chronic total occlusion percutaneous coronary intervention in a patient who has undergone previous cardiac surgery can have multiple causes, one of which is chamber compression from a localized haematoma due ...
Sun Lijun L Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, - - 2014
Heart disease is among the leading causes of death worldwide, and the limited proliferation of mammalian cardiomyocytes prevents heart regeneration in response to injury. Bone morphogenetic protein-10 (BMP10) exerts multiple roles in various developmental events; however, the effect of BMP10 and the underlying mechanism involved in cardiac repair remains unclear. ...
Lossie Janine J University Medicine Berlin Charité, Experimental and Clinical Research Center (ECRC), - - 2014
The essential myosin light chain (ELC) is involved in modulation of force generation of myosin motors and cardiac contraction, while its mechanism of action remains elusive. We hypothesized that ELC could modulate myosin stiffness which subsequently determines its force production and cardiac contraction. We therefore generated heterologous transgenic mouse (TgM) ...
Adhyapak Srilakshmi M SM Department of Cardiology, St John's Medical College Hospital, Bangalore, India - - 2014
In patients with previous myocardial infarction, the remote uninfarcted regions, although contractile, demonstrate dysfunctional wall kinetics because of increased afterload, which improves after surgical ventricular restoration (SVR). We characterized left ventricular (LV) mean myocardial velocity (MMV) through an analysis of endocardial motion and wall thickening (WT) over the cardiac cycle ...
Meyer Christian G CG Medical Clinic I, University RWTH Aachen, Pauwelsstraße 30, Aachen 52074, - - 2014
This study analysed the impact of transapical (TA) vs. transfemoral (TF) access site transcatheter aortic valve implantation (TAVI) on post-procedural regional left ventricular (LV) function using cardiac magnetic resonance (CMR) feature tracking (FT). CMR was performed 3 months after TAVI on 44 consecutive patients with normal LV ejection fraction prior ...
Yi Colin J CJ Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Rm 10/1C355, Bethesda, MD, 20892, - - 2014
To evaluate long-term changes in diffuse myocardial fibrosis using cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) and T1 mapping. Patients with chronic stable cardiomyopathy and stable clinical status (n = 52) underwent repeat CMR at a 6 month or greater follow up interval and had LGE and left ventricular (LV) T1 ...
Hasumi Yukiko Y Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, - - 2014
Cardiac hypertrophy, an adaptive process that responds to increased wall stress, is characterized by the enlargement of cardiomyocytes and structural remodeling. It is stimulated by various growth signals, of which the mTORC1 pathway is a well-recognized source. Here, we show that loss of Flcn, a novel AMPK-mTOR interacting molecule, causes ...
Muehling Olaf M - - 2014
Conventional cardiac pacemakers are still often regarded as a contraindication to magnetic resonance imaging (MRI). We conducted this study to support the hypothesis that it is safe to scan patients with cardiac pacemakers in a 1.5 Tesla MRI, if close supervision and monitoring as well as adequate pre- and postscan ...
Caetano Francisca F Serviço de Cardiologia, Hospital Geral, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address: - - 2014
The prognostic value of late gadolinium enhancement (LGE) for risk stratification of hypertrophic cardiomyopathy (HCM) patients is the subject of disagreement. We set out to examine the association between clinical and morphological variables, risk factors for sudden cardiac death and LGE in HCM patients. From a population of 78 patients ...
Wu Cho-Kai CK Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, - - 2014
Anti-anxiety medication in patients with anxiety may lessen the stress and thereby lower their risk for myocardial infarction (MI). The aim of current study is to examine an association between the use of anti-anxiety medication and long-term mortality risk in patients following MI. A universal national health insurance (NHI) program ...
Almehmadi Fahad F Department of Internal Medicine, Department of Medicine, London Health Sciences Centre, London, - - 2014
-Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) is increasingly performed in patients with systolic dysfunction. Numerous patterns of fibrosis are commonly reported among this population. However, the relative prevalence and prognostic significance of these findings remains uncertain. -Three hundred and eighteen consecutive patients referred for LGE-CMR and a left ...
Lin Zhiqiang Z Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, - - 2014
Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable to overcome the fundamental problem of regenerating lost cardiomyocytes. Several strategies for promoting heart regeneration have emerged from decades of intensive study. Although some of these strategies remain confined ...
García-Lunar Inés I Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España; Servicio de Cardiología, Hospital Universitario Quirón, Universidad Europea de Madrid, Madrid, España; Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, - - 2014
Cardiac resynchronization therapy is associated with improved quality of life and reduced morbidity and mortality in patients with severe ventricular dysfunction and wide QRS. However, its role in the reduction of ventricular arrhythmias is more controversial. We compared the incidence of ventricular arrhythmias in patients who were undergoing cardiac resynchronization ...
Lal Hind H Temple University School of Medicine, Philadelphia, - - 2014
-Myocardial infarction-induced remodeling includes chamber dilatation, contractile dysfunction, and fibrosis. Of these, fibrosis is the least understood. Following MI, activated cardiac fibroblasts (CFs) deposit extracellular matrix. Current therapies to prevent fibrosis are inadequate and new molecular targets are needed. -Herein we report that GSK-3β is phosphorylated (inhibited) in fibrotic tissues ...
Marcinkiewicz Anna - - 2014
Off-pump coronary artery bypass (OPCAB) surgery can be associated with some intrinsic, but relatively rare complications. A pericardial effusion is a common finding after cardiac surgeries, but the prevalence of a cardiac tamponade does not exceed 2% and is less frequent after myocardial revascularization.Authors believe that in our patient an ...
Tuomainen Petri O PO Department of Internal Medicine and Heart Center, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finlandia; Department of Cardiology, Satakunta Central Hospital, Pori, - - 2014
We performed a pooled analysis based on patient-level data from the TITAX-AMI and BASE-ACS trials to evaluate the outcome of titanium-nitride-oxide-coated bioactive stents vs drug-eluting stents in patients with ST-segment elevation myocardial infarction at 2-year follow-up. The TITAX-AMI trial compared bioactive stents with paclitaxel-eluting stents in 425 patients with acute ...
Mortensen Eric M EM VA North Texas Health Care System, Dallas2University of Texas Southwestern Medical Center, - - 2014
Although clinical practice guidelines recommend combination therapy with macrolides, including azithromycin, as first-line therapy for patients hospitalized with pneumonia, recent research suggests that azithromycin may be associated with increased cardiovascular events. To examine the association of azithromycin use with all-cause mortality and cardiovascular events for patients hospitalized with pneumonia. Retrospective ...
Finsterer Josef J Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: - - 2014
Myosin-heavy-chain 7 (MYH7)-myopathy manifests clinically with a distal, scapuloperoneal, limb-girdle (proximal), or axial distribution and may involve the respiratory muscles. Cardiac involvement is frequent, ranging from relaxation impairment to severe dilative cardiomyopathy. Progression and earlier onset of cardiac disease in successive generations with MYH7-myopathy is unreported. In a five-generation family ...
Adhyapak Srilakshmi M SM Department of Cardiology, St John's Medical College Hospital, Bangalore, India - - 2014
Clinical outcomes of surgical ventricular restoration (SVR) have been confirmed by Registry data. Accurate assessment of left ventricular (LV) morphology and function can help optimize these outcomes. LV remodelling in 7 patients (NYHA class 3 ± 1.2) with post-myocardial infarction LV aneurysms was characterized by the regional LV volume (RLVV) ...
Tuomainen Petri O PO Department of Internal Medicine and Heart Center, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland; Department of Cardiology, Satakunta Central Hospital, Pori, - - 2014
We performed a pooled analysis based on patient-level data from the TITAX-AMI and BASE-ACS trials to evaluate the outcome of titanium-nitride-oxide-coated bioactive stents vs drug-eluting stents in patients with ST-segment elevation myocardial infarction at 2-year follow-up. The TITAX-AMI trial compared bioactive stents with paclitaxel-eluting stents in 425 patients with acute ...
Manabe Osamu O Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Cardiac sarcoidosis is most commonly found in the left ventricular (LV) free wall. Presence in the right ventricle (RV) is less common but might be useful for detecting cardiac involvement of sarcoidosis. (18)F-fluorodeoxyglucose ((18)F-FDG) PET has been used to detect LV regions with cardiac sarcoidosis. However, the same has not ...
Trolese Luca L Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, - - 2014
The choice of left ventricular pacing configurations (LVPCs) of quadripolar leads used for cardiac resynchronization therapy (CRT) affects haemodynamic response and thus may be a tool for device optimization. The value of surface electrocardiograms and interventricular time delays (IVDs) for optimization is unknown. Sixteen patients implanted with a CRT device ...
Lee AhYoung A Icahn School of Medicine at Mount Sinai, Cardiovascular Research Center, New York, New York, United States ; - - 2014
Small ubiquitin-like modifier type 1 (SUMO-1) has been shown to play a critical role in the dysfunction of the cardiac isoform of the sarcoplasmic reticulum calcium ATPase pump (SERCA2a) in the setting of heart failure. In cardiac hypertrophy, the role of SUMO-1 has not been defined and our study's goals ...
Pedrizzetti Gianni G Department of Engineering and Architecture, University of Trieste, Piazzale Europa, 1, 34127 Trieste, - - 2014
Blood motion in the heart features vortices that accompany the redirection of jet flows towards the outlet tracks. Vortices have a crucial role in fluid dynamics. The stability of cardiac vorticity is vital to the dynamic balance between rotating blood and myocardial tissue and to the development of cardiac dysfunction. ...
Nudi Francesco F Service of Nuclear Cardiology, Madonna della Fiducia Clinic, Via Cesare Correnti 6, 00179, Rome, Italy, - - 2014
Myocardial perfusion scintigraphy (MPS) represents a key prognostic tool, but its predictive yield is far from perfect. We developed a novel clinically relevant segmentation method and a corresponding maximal ischemia score (MIS) in order to risk-stratify patients undergoing MPS. Patients referred for MPS were identified, excluding those with evidence of ...
Glaubitz Michael M ZIK-HIKE - Zentrum für Innovationskompetenz "Humorale Immunreaktionen bei kardiovaskulären Erkrankungen", University Medicine - - 2014
Background:Ventricular dilation is known as a pivotal predictor in recent-onset cardiomyopathy (ROCM), but its pathophysiology is not fully understood. In the present study we investigated whether single-cell stiffness of right and left ventricular-derived fibroblasts has an effect on cardiac phenotype in patients with ROCM.Methods and Results:Patients with endomyocardial biopsy-proven ROCM were included ...
Sahin Irfan I Department of Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey - - 2014
Atrial fibrillation (AF) after cardiac surgery has been reported to be approximately 30%, making it one of the most important causes of morbidity and mortality post surgery. Although various clinical and laboratory predictors and underlying mechanisms progressing to postoperative AF have been proposed, the role of ischaemia in pathogenesis is ...
Mann Douglas L DL Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: - - 2014
Heart failure is a clinical syndrome caused by dysregulated calcium handling and abnormal cardiac pumping capacity. Wahlquist et al. (2014) show that upregulation of microRNA-25 impairs calcium handling leading to pump dysfunction and that targeting microRNA-25 using antisense oligonucleotides reverses pump dysfunction and improves survival in mice with heart failure.
Neijts Melanie M Department of Biological Psychology, Vrije University (VU) Amsterdam, Amsterdam, The Netherlands; EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The - - 2014
This study estimated the heritability of 24-h heart rate variability (HRV) measures, while considering ceiling effects on HRV at low heart rates during the night. HRV was indexed by the standard deviation of all valid interbeat intervals (SDNN), the root mean square of differences between valid, successive interbeat intervals (RMSSD), ...
Mohammed M I MI Heriot-Watt University, MIcroSystems Engineering Centre (MISEC), Research Institute of Signals, Sensors and Systems (ISSS), School of Engineering and Physical Sciences, Earl Mountbatten Building, Edinburgh, EH14 4AS Scotland, UK. Electronic address: - - 2014
Cardiovascular diseases are the most prevalent medical conditions affecting the modern world, reducing the quality of life for those affected and causing an ever increasing burden on clinical resources. Cardiac biomarkers are crucial in the diagnosis and management of patient outcomes. In that respect, such proteins are desirable to be ...
Derval Nicolas N Hopital Cardiologique du Haut Lévêque, CHU Bordeaux, Pessac, - - 2014
Recent studies have demonstrated that LV pacing site is a critical parameter in optimizing cardiac resynchronization therapy (CRT). The present study evaluates the effect of pacing from different LV locations on QRS duration (QRSd) and their relationship to acute hemodynamic response in congestive heart failure (CHF) patients. Thirty-five patients with ...
Ghavami S - - 2014
Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the intracellular milieu by removal of ...
Kudo-Sakamoto Yoko Y Osaka University, - - 2014
Enzymatic proteolysis by calpains, Ca(2+)-dependent intracellular cysteine proteases, has been implicated in pathological processes such as cellular degeneration or death. Here, we investigated the role of calpain activation in the hearts subjected to myocardial infarction. We produced myocardial infarction in Cast(-/-) mice deficient for calpastatin, the specific endogenous inhibitory protein ...
Webber Matthew M Royal Free - - 2014
Cardiac involvement is a well described complication in Systemic Sclerosis (SSc) and is considered to be one of the leading causes of mortality. Cardiac MRI (CMR) is an emerging tool that can add new information on fibrosis and inflammation. Its use in SSc is not well described and is limited ...
Williams Howell J HJ Department of Cardiology, Barts Health NHS - - 2014
Knowledge of cardiac arrest (CA) causes other than coronary artery disease is derived predominantly from post-mortem studies, identifying hypertrophic cardiomyopathy (HCM) as the commonest diagnosis. Management of CA survivors mandates definite attempts towards diagnosis, particularly as the cause may be inherited with implications for family screening. Our approach to non-ischaemic ...
Penciu Oana-Maria OM Department of Internal Medicine, Western Connecticut Health Network, Danbury Hospital, Danbury, - - 2014
Hypertrophic cardiomyopathy and anomalous origin of the coronary artery from the opposite sinus are common causes of sudden cardiac death. These entities have rarely been reported together. Here we present the case of a 48-year-old woman with hypertrophic cardiomyopathy and significant left ventricular outflow tract obstruction. She was referred for ...
Kydd Anna C AC Department of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United - - 2014
This study was conducted to assess the impact of left ventricular (LV) lead position on longer-term survival after cardiac resynchronization therapy (CRT). An optimal LV lead position in CRT is associated with improved clinical outcome. A strategy of speckle-tracking echocardiography can be used to guide the implanter to the site ...
Zaman Maseeh Uz MU 1 Department of Radiology, The Aga Khan University Hospital (AKUH), Karachi, Pakistan ; 2 Department of Nuclear Cardiology, Karachi Institute of Heart Diseases (KIHD), Karachi, Pakistan ; 3 Department of Nuclear Medicine, Dr Ziauddin Medical University, Karachi, Pakistan ; 4 MBBS Students, Dow University of Health Sciences (DUHS), Karachi, - - 2014
The negative predictive value of a normal single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is very high. However, prognostic implication of a normal SPECT MPI in patients with known coronary artery disease (CAD) is not clear. Objective of this study was to evaluate the cardiac event rate in ...
Yu Jin Xu X Oxford University - - 2014
A precise understanding and quantification of myocardial contraction is essential for optimising peri-operative care in high risk CABG surgery. Conventional approach has been focused on the magnitude of myocardial contraction, while its time course has received little clinical attention. This study was aimed to characterise the changes in both physiological ...
Link Mark S MS The Cardiac Arrhythmia Center, Tufts Medical Center, 800 Washington Avenue, Boston, MA, 02111, USA, - - 2014
Commotio cordis is increasing described and it is now clear that this phenomenon is an important cause of sudden cardiac death on the playing field. Victims are predominantly young, male, and struck in the left chest with a ball. An animal model has been developed and utilized to explore the ...
Ferreira Vanessa V University of - - 2014
Sudden and/or chronic exposure to catecholamines may predispose patients with phaeochromocytoma to cardiac pathology, including left ventricular (LV) hypertrophy, myocardial infarction, stress-induced cardiomyopathy and heart failure. This is a prospective, multicentre study using cardiovascular magnetic resonance (CMR) imaging to describe the variety and incidence of cardiac abnormalities in patients diagnosed ...
Arndt-H Kiessling K Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, - - 2014
Background: Myoglobin has become established as a serum marker of myocardial injury. However, myoglobin levels can increase exponentially without any correlation to postoperative clinical ischemia symptoms. In this retrospective study, we analyzed the associated factors for a non-ischemic myoglobin release.Methods: We performed a data analysis from 532 consecutive cardiac surgery ...
Martinez Sara C SC Department of Internal Medicine, Cardiovascular Division (Drs. Bradley, Cedars, Ewald, Joseph, Martinez, and Rasalingam; and Mr. Novak), and Department of Surgery, Division of Cardiothoracic Surgery (Dr. Silvestry), Washington University School of Medicine in St. Louis, St. Louis, Missouri - - 2014
Left ventricular assist device (LVAD)-supported patients are evaluated routinely with use of transthoracic echocardiography. Values of left ventricular unloading in this unique patient population are needed to evaluate LVAD function and assist in patient follow-up. We introduce a new M-mode measurement, the slope of the anterior mitral valve leaflet (SLAM), ...
Zaman Junaid J Imperial College - - 2014
Hypertension and ageing are the commonest risk factors for atrial fibrillation (AF) and a significant cause of ventricular dysfunction, which may lead to arrhythmia. Putative factors in the remodelled substrate are connexin 43 (Cx43), the most abundant cardiac gap junction and fibrosis. The spontaneous hypertensive rat (SHR) has been demonstrated ...
Löfsjögård Johan J aDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet bDepartment of Cardiology, Danderyd University Hospital, Stockholm, Sweden cDivision of Cardiovascular Sciences, Centre of Applied Medical Research dDepartment of Cardiology and Cardiac Surgery, School of Medicine, University of Navarra, Pamplona, Spain eErsta Hospital, Stockholm, - - 2014
Myocardial collagen metabolism can be assessed indirectly by circulating biomarkers. We aimed to examine associations between myocardial collagen type I synthesis and degradation, and echocardiographic, clinical, and B-type natriuretic peptide (BNP) findings in heart failure. We studied 57 women and 75 men 60 years or older with systolic heart failure ...
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