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Sciarretta Sebastiano S From the Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ (S.S., J.S.); IRCCS Neuromed, Pozzilli, Italy (S.S., M.V.); and Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University Sapienza, Rome, Italy - - 2014
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 regulates protein synthesis, cell growth and proliferation, ...
Oka Toru T From the Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan (T.O., A.T.N., I.K.); Departments of Advanced Clinical Science and Therapeutics (H.A.) and Cardiovascular Medicine (H.A., A.T.N., I.K.), The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan; and Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan (T.O., H.A., A.T.N., - - 2014
Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In response to the overload, individual cardiac myocytes become mechanically stretched and activate intracellular hypertrophic signaling pathways to re-use embryonic transcription factors and to increase the synthesis of various proteins, such as structural and contractile proteins. These hypertrophic responses ...
Hosseinipour M M Dynamic and Smart Systems Laboratory, The University of Toledo, Toledo, OH, USA, - - 2014
Ventricular assistive devices are approved by Food and Drug Administration as an alternative to heart transplant for congestive heart failure patients. Unlike other devices requiring open-heart surgery, thin active flexible membrane of IntraVAD, made of ionic polymer-metal composites and shape memory alloys (SMA), enables transcatheter implantation and eliminates thoracotomy. Actuation ...
De Ferrari Gaetano M GM Department of Cardiology and Cardiovascular Clinical Research Center, Fondazione IRCCS Policlinico San Matteo, Pavia, - - 2014
Heart failure (HF) is characterized by an autonomic imbalance with withdrawal of vagal activity and increased sympathetic activity. Novel non-pharmacological approaches to HF aimed at increasing vagal activity are being proposed. Left cardiac sympathetic denervation (LCSD) has been shown to modify favorably the outcome of several disorders characterized by life-threatening ...
Arcadi Teresa T SDN Foundation, IRCCS, Naples, - - 2014
A 54-year-old male with history of cocaine abuse underwent trans-thoracic echocardiography that showed hyper-echogenicity of the basal segments of the septum and infero-lateral wall of the left ventricle. The patient underwent cardiac CT that reported diffuse non-obstructive CAD. Cardiac MR showed LGE patterns consistent with non-ischemic myocardial damage associated with ...
Fujiu Katsuhito K Department of Cardiovascular Medicine, the University of Tokyo Graduate School of Medicine, Tokyo; Translational Systems Biology and Medicine Initiative (TSBMI), the University of Tokyo Graduate School of Medicine, Tokyo. Electronic address: - - 2014
Under normal physiological conditions, cardiac fibroblasts are the primary producers of extracellular matrix and supply a mechanical scaffold for efficacious heart contractions induced by cardiomyocytes. In the hypertrophic heart, cardiac fibroblasts provide a pivotal contribution to cardiac remodeling. Many growth factors and extracellular matrix components secreted by cardiac fibroblasts induce ...
Janusek D D Department for Biophysical Measurements and Imaging, Nalecz Institute of Biocybernetic and Biomedical Engineering PAS, 4 Ks. Trojdena Str., 02-109 Warsaw, Poland. Electronic address: - - 2014
The presence of T wave alternans (TWA) in the surface ECG signals has been recognized as a marker of electrical instability, and is hypothesized to be related to patients at increased risk for ventricular arrhythmias. In this paper we present a TWA simulation study. The TWA phenomenon was simulated by ...
Raposeiras-Roubín Sergio S Department of Cardiology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain. Electronic address: - - 2014
In light of the low cost, the widespread availability of the electrocardiogram, and the increasing economic burden of the health-related problems, we aimed to analyze the prognostic value of automatic frontal QRS-T angle to predict mortality in patients with left ventricular (LV) systolic dysfunction after acute myocardial infarction (AMI). About ...
Posnack Nikki Gillum NG Department of Pharmacology & Physiology, The George Washington University, Washington, DC, - - 2014
Bisphenol A (BPA) is used to produce polycarbonate plastics and epoxy resins that are widely used in everyday products, such as food and beverage containers, toys and medical devices. Human biomonitoring studies have suggested that a large proportion of the population may be exposed to BPA. Recent epidemiological studies have ...
Krumm Patrick P Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, - - 2014
Percutaneous mitral valve repair (MVR) with the MitraClip(®) system in patients with mitral regurgitation (MR) is known to reduce symptoms and to improve cardiac morphology and function. MitraClip has been approved for cardiac magnetic resonance imaging (MRI). To date, however, no systematic analysis exists on cardiac MRI in patients undergoing ...
Ellims Andris H AH 1Heart Centre, Alfred Hospital, Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, - - 2014
-In hypertrophic cardiomyopathy (HCM), accumulation of myocardial collagen may play a central role in the pathogenesis of diastolic dysfunction and arrhythmia. Previous studies have suggested that peripheral levels of byproducts of collagen synthesis are reflective of myocardial extracellular matrix metabolism although this has not been validated in detail. Given the ...
Yamane Tomohiko T Department of Nuclear Medicine, University of Würzburg, Würzburg, - - 2014
The assessment of myocardial radiotracer kinetics, including cardiac extraction fraction and washout, requires the study of isolated perfused hearts to avoid analytic error due to tracer recirculation and systemic metabolites. Analysis of the isolated perfused rat heart by a high-resolution small-animal PET system may offer both reliable evaluation of cardiac ...
Wittlieb-Weber Carol A CA Department of Pediatric Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States of - - 2014
We describe a case of influenza A myocarditis and transient left ventricular wall thickening in a 14-year-old girl presenting with acute heart failure. Admission echocardiogram revealed significant left ventricular hypertrophy with depressed left ventricular systolic function. The aetiology of the ventricular thickening was demonstrated to be myocardial oedema using cardiac ...
Seropian Ignacio M IM Cardiology Department, FLENI Foundation, Buenos Aires, - - 2014
Acute myocardial infarction (AMI) leads to molecular, structural, geometrical and functional changes in the heart in a process known as ventricular remodeling. An intense organized inflammatory response is triggered after myocardial ischemia and necrosis, and involves all components of the innate immunity, affecting both cardiomyocytes and non-cardiomyocyte cells. Inflammation is ...
Francis Gary S GS Department of Medicine-Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA. Electronic address: - - 2014
Inotropes have been fundamental to resuscitation of acute cardiogenic shock for decades. Heart failure, and in severe cases, cardiogenic shock are syndromes characterized in many patients by a reduction in myocardial contractile force. While inotropes successfully increase cardiac output, their use has been plagued by excessive mortality due to increased ...
Chawla Lakhmir S LS Department of Medicine, Division of Nephrology, Washington DC Veterans Affairs Medical Center, Washington, DC, USA; Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington, DC. Electronic address: - - 2014
Structural heart disease is highly prevalent in patients with chronic kidney disease requiring dialysis. More than 80% of end-stage renal disease (ESRD) patients are reported to have cardiovascular disease (CVD). This observation has enormous clinical relevance, as the leading causes of death for ESRD patients are of CVD etiology, including ...
Bösch Florian F Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria; Department of Surgery, Ludwig-Maximilians University Munich, Munich, - - 2014
Ischemia and reperfusion contribute to substantial organ damage in transplantation. Clinically feasible measures for the prevention thereof are scarce. We tested if rinsing rodent hearts with the antioxidant bilirubin ameliorates IRI. Left ventricular end diastolic pressure (LVEDP), left ventricular developed pressure (LVDevP), rate per pressure product (RPP), coronary flow, maximum ...
Gjerdalen G F GF Section of Vascular Investigations, Oslo University Hospital, Aker, Oslo, Norway; Bjorknes College, Oslo, - - 2014
This investigation explores the cardiac four-chamber remodeling response to training in male players in Norwegian professional football league, and ethnicity as determinants in the development of athlete's heart. Standard 2D echocardiographic examination and analysis of all four cavities were performed in 504 football players of Caucasian origin, 49 of African ...
Tandon Animesh A 1 The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of - - 2014
We present the case of a 29-year-old man with mutation-positive Duchenne muscular dystrophy and mutation-positive hypertrophic cardiomyopathy. His cardiac phenotype has characteristics of both disorders; he manifests sub-epicardial left ventricular free wall late gadolinium enhancement that is consistent with Duchenne cardiomyopathy, as well as asymmetric ventricular septal hypertrophy, hyperdynamic left ...
Cantinotti Massimiliano M Fondazione Toscana G. Monasterio, Ospedale del Cuore, via Aurelia Sud, 54100, Massa, Pisa, Italy, - - 2014
The aim of this article is to review the diagnostic and prognostic relevance of measurement of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in pediatric patients with heart failure caused by various acquired and congenital heart diseases (CHD). In January 2013, we performed a computerized literature search ...
Parodi Emily M EM Harvard Medical School, Boston Children's Hospital, Brookline, MA UNITED - - 2014
Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding neuregulins, explaining their roles in transducing signals between the ...
Fantidis Panayotis P 1Servicio de Cirugía Cardiovascular, Hospital Universitario Infanta Cristina, Avenida de Elvas, Badajoz, - - 2014
Encouraging results were obtained by using left ventricular assist devices (LVADs) in patients with end-stage heart failure (HF) that exhibits extremely high mortality and who were not candidates for heart transplantation. By using this so-called destination therapy (DT), a substantial percentage of these patients achieved sufficient improvement in cardiac function ...
Kunita Eiji E Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, - - 2014
Epicardial adipose tissue (EAT) accumulation is believed to be associated with development of coronary atherosclerosis. We investigated whether EAT volume as assessed by computed tomography (CT) has value in prediction of future cardiac events. We studied 722 patients without proven coronary artery disease (CAD) who underwent non-contrast cardiac CT. EAT ...
Zepeda Ramiro R *Advanced Center for Chronic Diseases & Centro Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile †Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile ‡Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein Drp1 inhibition, attenuates I/R injury through modifications in mitochondrial metabolism. Rats were subjected to ischemia-reperfusion (I/R) through coronary artery ligation and isolated cardiomyocytes were treated ...
Wang De-Guo DG Department of Gerontology, The Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. - - 2014
Mesenchymal stem cells (MSCs) with elevated levels of connexin 43 (Cx43) have been shown to exhibit improved protection for ischemic hearts. However, it remains unclear whether Cx43 is involved in the paracrine actions of angiogenesis, the major mechanism of cell therapy. In the present study, an in vitro model with deprivation of ...
Paternoster Gianluca G U.O.C. Cardioanesthesia and Cardio-Intensive Care, San Carlo Hospital, Potenza, - - 2014
Background/Aims: Cardiopulmonary bypass (CPB) has been thought to promote endotoxin translocation from the gut. Increased endotoxin activity (EA) has been related to a worsening of organ dysfunction, particularly acute kidney injury (AKI). This study aims to determine if CPB could influence EA after cardiac surgery, and if EA variations are ...
Rademakers Leonard M LM Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands. Electronic address: - - 2014
Endocardial left ventricular (LV) pacing for cardiac resynchronization therapy (CRT) has been proposed as an alternative to traditional LV transvenous epicardial pacing with equal or superior cardiac performance. The risk of cerebral thromboembolism and possible interference with mitral valve function moderates its clinical application. This study investigates cerebral thromboembolic complications ...
Yune Sehyo S 0000-0002-9223-3586 Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
A 53-yr-old man underwent radiofrequency ablation to treat persistent atrial flutter. After the procedure, the chest pain was getting worse, and the electrocardiogram showed ST-segment elevation in inferior leads with reciprocal changes. Immediate coronary angiography showed total occlusion with thrombi at the distal portion of the right coronary artery, which ...
Plowright Alleyn T AT Department of Medicinal Chemistry, Cardiovascular and Metabolic Diseases Innovative Medicines, AstraZeneca, Pepparedsleden 1, Mölndal, 43183 (Sweden). - - 2014
Following a heart attack, more than a billion cardiac muscle cells (cardiomyocytes) can be killed, leading to heart failure and sudden death. Much research in this area is now focused on the regeneration of heart tissue through differentiation of stem cells, proliferation of existing cardiomyocytes and cardiac progenitor cells, and ...
Brémont Camille C APHP, Cardiovascular Department and INSERM U955, Henri Mondor University Hospital, Creteil, - - 2014
Coupled pacing (CP), which consists of an additional beat delivered after ventricular refractory period, has been proposed to reduce ventricular rate and increase ventricular contractility. We hypothesized that CP may be added to cardiac resynchronization therapy (CRT) to improve CRT effect in heart failure (HF) patients. The study included 20 ...
Socher M M Animal Laboratory Facility, German Cancer Research Center (DKFZ), Heidelberg, - - 2014
Cardiac perfusion studies using computed tomography are a common tool in clinical practice. Recent technical advances and the availability of dedicated small animal scanners allow the transfer of these techniques to the preclinical sector in general and to mouse models of cardiac diseases in particular. This necessitates new requirements for ...
Karapanagiotidis Gt G Department of Cardiothoracic Surgery, St George's Hospital, London, - - 2014
A 72-year-old female presented with severe ischaemic mitral regurgitation following a recent myocardial infarction. She had no significant past medical history.Pre-operative echocardiogram assessment demonstrated preserved tendinous cords of the mitral leaflets, a mitral valve annulus measuring 3.2 cm with end systolic coaptation of 0.3 cm, impaired left ventricular function with ...
Pastore Gianni G Department of Cardiology, Rovigo General Hospital, Via Tre Martiri, 140 45100 Rovigo, - - 2014
Right ventricular apex (RVA) pacing has adverse effects on left atrial (LA) function and may contribute to atrial arrhythmias. The effects of Hisian area (HA) pacing on LA function are still lacking.The objective of this study is to assess the left ventricular (LV) electromechanical activation/relaxation, systolic (S), diastolic (D) phases, ...
Gupta Deepak K DK Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
Chronically supported left ventricular assist device (LVAD) patients may be candidates for novel therapies aimed at promoting reverse remodeling and myocardial recovery. However, the effect of hemodynamic unloading with a LVAD on myocardial viability and LV function in chronically supported LVAD patients has not been fully characterized. We aimed to ...
Jørgensen Peter Hartmund PH Department of Cardiology, Odense University Hospital, Odense C, - - 2014
The clinical classification of myocardial infarction (MI) into five types was introduced in 2007 as a component of the universal definition. A Type 5 MI was defined as a MI related to coronary artery bypass surgery. In a setting of patients undergoing elective coronary artery bypass grafting, we set out ...
Groban Leanne L Department of Anesthesiology (L.G.), Department of Internal Medicine, Section on Cardiology (D.W.K.), Department of Pathology, Section on Comparative Medicine (T.C.R., C.A.S.), Wake Forest School of Medicine, Winston-Salem, North - - 2014
ObjectiveDepression is a proposed risk factor for heart failure based largely on epidemiological data; few experimental data addressing this hypothesis are available.MethodsDepression was evaluated in relation to cardiac structural and functional phenotypes assessed by transthoracic echocardiography in 42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years. ...
Alghamdi Mohammed H MH King Abdulaziz Medical City, Riyadh ; King Fahad Cardiac Centre, King Saud University, - - 2014
A 9.5-month-old boy with Down syndrome, weighing 4.8 kg, presented with history of failure to thrive. Clinically, he had symptoms and signs of congestive heart failure. His echocardiogram showed a large perimembranous ventricular septal defect (pmVSD) with some inlet extension covered by a large aneurysmal tissue with multiple right ventricular (RV) ...
Sato Takamasa T Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan, - - 2014
We determine the importance of indicators of nutrition including lymphocyte, total protein, albumin, cholinesterase and body mass index, and compare the prognostic significance in chronic heart failure (CHF). We examined consecutive 465 CHF patients (376 males, age 62 ± 14 years) who underwent cardiopulmonary exercise testing, echocardiography and blood examination including indicators of ...
Salinski Ellie P EP Department of Emergency Medicine, Lehigh Valley Health Network, Allentown, - - 2014
Diagnosed ST-segment elevation myocardial infarction (STEMI) usually prompts rapid cardiac catheterization response. Our aim was to raise awareness that hypothermia can cause electrocardiographic (ECG) changes that mimic STEMI. Emergency Medical Services (EMS) was called for altered mental status and lethargy in a 47-year-old man with a medical history of paraplegia. ...
Greenberg Barry B Division of Cardiovascular Medicine, University of California at San Diego, San Diego, California. Electronic address: - - 2014
Impaired cardiac isoform of sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a) activity is a key abnormality in heart failure patients with reduced ejection fraction. The CUPID 2 (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b) trial is designed to evaluate whether increasing SERCA2a activity via gene therapy ...
Khazanie Prateeti P Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina; Department of Medicine, Duke University School of Medicine, Durham, North - - 2014
This study sought to examine the long-term outcomes of patients hospitalized with heart failure and atrial fibrillation. Atrial fibrillation is common among patients hospitalized with heart failure. Associations of pre-existing and new-onset atrial fibrillation with long-term outcomes are unclear. We analyzed 27,829 heart failure admissions between 2006 and 2008 at ...
Alghamri Mahmoud S MS Wright State - - 2014
Aminopeptidase-A (APA) is a less well-studied enzyme of the renin angiotensin system. We propose that it is involved in cardiac Angiotensin (Ang) metabolism and its pathologies. Ang-(1-7) can ameliorate remodeling after myocardial injury. The aims of this study are to (1)Develop mass spectrometric (MS) approaches for the assessment of Ang ...
Bogaert Jan J Departments of *Radiology †Nuclear Medicine ‡Cardiovascular Diseases, UZ Leuven, Leuven, - - 2014
Ischemic heart failure is probably the most challenging issue in cardiology today, posing an enormous medical and financial burden on our society. Conceptually, it represents a maladaptive cardiac remodeling due to acute and/or chronic coronary artery disease with varying degrees of left ventricular dilatation and dysfunction. Although therapeutic options have ...
Sifain Andrew R AR Department of Medicine, Department of Surgery, and Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, - - 2014
While ventricular assist devices (VADs) are lifesaving therapy for patients with severe heart failure, complications such as pump thrombosis can occur. In this report we present a case of VAD thrombosis following recovery of left ventricular (LV) function. The patient had been supported with a VAD for eight months and ...
Liu Meifang M Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, - - 2014
MicroRNA-1 (miR-1) has been found in cardiac and skeletal tissues. It is overexpressed in ischemic cardiac tissues. Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). To increase the therapeutic efficiency and inhibit off-target effects of AMO-1, here we explored anti-cardiac troponin I (cTnI) antibody modified liposomes ...
Wu Hongquan H Department of Cardiology, Second Affiliated Hospital, Chongqing Medical University, Chongquing, PR - - 2014
Objectives: The objective of this study was to determine the effect of inhibiting malonyl-CoA decarboxylase (MCD) on cardiac remodeling following myocardial infarction (MI) in rats. We used an ultrasound (US)-mediated microbubble (MB) approach for targeted delivery of a microRNA (miRNA) interference plasmid to the myocardium to silence MCD expression. Methods: ...
Liu Chia-Ying CY Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United - - 2014
Cardiac steatosis is common in patients with diabetes or obesity, and cardiac steatosis may result in cardiomyopathy. However, factors associated with cardiac steatosis have not been reported in healthy individuals without diabetes and hypertension. The objectives of this study were to explore factors associated with myocardial triglyceride levels, and to ...
Kapelios Chris J CJ 3rd Department of Cardiology, University of Athens School of Medicine, - - 2014
The intra-aortic balloon pump (IABP), which is the main representative of the counterpulsation technique, has been an invaluable tool in cardiologists' and cardiac surgeons' armamentarium for approximately half a century. The IABP confers a wide variety of vaguely understood effects on cardiac physiology and mechano-energetics. Although, the recommendations for its ...
Nakamura Yuichi Y Department of Cardiology and Hematology, Fukushima Medical - - 2014
Background: Cardiac troponins are independent predictors of cardiac mortality in patients with heart failure (HF). Recently, elevation of troponins was described in non-cardiac diseases such as stroke and infection, among others, but it remains unclear whether high-sensitivity troponin T (hs-TnT) predicts non-cardiac mortality in HF patients. Methods and Results: Four-hundred and forty-four ...
Glaudemans Andor W J M AW Department of Nuclear Medicine and Molecular Imaging - - 2014
Abstract Objective: To assess the usefulness of bone scintigraphy with (99m)Technetium-hydroxymethylene diphosphonate ((99m)Tc-HDP) for the detection of cardiac involvement in a group of patients with ATTR amyloidosis in different phases of disease, to relate the findings to echocardiography, ECG and cardiac biomarkers, and to evaluate different bone scintigraphic techniques and ...
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