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Cavalera Michele M Division of Cardiology, Department of Medicine, The Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New - - 2014
Cardiac fibrosis is strongly associated with obesity and metabolic dysfunction and may contribute to the increased incidence of heart failure, atrial arrhythmias, and sudden cardiac death in obese subjects. This review discusses the evidence linking obesity and myocardial fibrosis in animal models and human patients, focusing on the fundamental pathophysiological alterations ...
Groeneweg J A JA Department of Cardiology, University Medical Center Utrecht, HP Q05.2.314, Heidelberglaan 100, PO Box 85500, 3508 GA, Utrecht, the Netherlands, - - 2014
Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), is a hereditary disease characterised by ventricular arrhythmias, right ventricular and/or left ventricular dysfunction, and fibrofatty replacement of cardiomyocytes. Patients with AC typically present between the second and the fourth decade of life with ventricular tachycardias. However, sudden cardiac ...
Perdreau Elodie E Service de Cardiologie Congénitale et Pédiatrique, Hôpital du Haut-Lévêque, CHU Bordeaux, Avenue de Magellan, 33604, Pessac, France, - - 2014
Tramadol is a common analgesic, widely prescribed because of its efficiency and safety. We report the case of a 7-year-old child admitted in cardiac intensive care unit for cardiogenic shock due to tramadol intoxication. Without any past history, the child was admitted at emergency room for generalised convulsion, followed by ...
Lo K Y KY Division of Cardiology, Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong - - 2014
OBJECTIVE. To evaluate the intermediate-term outcomes of patients with unprotected left main coronary artery stenosis who were treated with percutaneous coronary intervention in Hong Kong. DESIGN. Historical cohort. SETTING. A regional hospital in Hong Kong. PATIENTS. Patients with unprotected left main coronary artery disease undergoing stenting with bare-metal stents or ...
Gomes Katia M S KM Department of Anatomy, Institute of Biomedical - - 2014
We previously demonstrated that pharmacological activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion injury. Here we determined the benefits of chronic activation of ALDH2 on the progression of heart failure using a post-myocardial infarction model.Methods and ResultsWe showed that a six-week treatment of myocardial infarction-induced ...
Osbourne Appledene A University of Chicago Institute for Cardiovascular Research, 5841S. Maryland Ave, MC 6080, Chicago, IL 60637. Electronic address: - - 2014
MicroRNAs (miRNAs) are now recognized as critical regulators of diverse physiological and pathological processes; however, studies of miRNAs and arrhythmogenesis remain sparse. Connexin43 (Cx43), a major cardiac gap junction protein, has elicited great interest in its role in arrhythmias. Additionally, Cx43 was a potential target for miR-130a as predicted by ...
Nishiuchi Tatsuya T Department of Acute Medicine, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan. Electronic address: - - 2014
The present study aimed to clarify the incidence and outcomes of sudden cardiac arrests in schools and the clinically relevant characteristics of individuals who experienced sudden cardiac arrests. We obtained data on sudden cardiac arrests that occurred in schools between January 1, 2005 and December 31, 2009 from the database ...
Zellweger Michael J MJ Division of Cardiology, University Hospital, Basel, Switzerland. Electronic address: - - 2014
This study sought to evaluate the prognostic value of routine stress myocardial perfusion scintigraphy (MPS) 5 years after percutaneous coronary intervention (PCI). Current appropriate use criteria define routine cardiac stress imaging <2 years after PCI as inappropriate and >2 years as uncertain in asymptomatic patients. All 339 of 683 BASKET ...
Lee Ki Hong KH Chonnam National University Hospital, Gwangju, South - - 2014
Cardiac arrest complicating acute ST elevation myocardial infarction (STEMI) is known to be associated with increased in-hospital mortality. However, little is known about the long-term outcomes after cardiac arrest complicating first onset STEMI in contemporary percutaneous coronary intervention (PCI) era. We analyzed 7942 consecutive patients who were diagnosed with STEMI ...
Givvimani Srikanth S Department of Physiology & Biophysics, School of Medicine, University of Louisville, KY 40202, - - 2014
Therapeutic approaches for cardiac regenerative mechanisms have been explored over the past decade to target various cardiovascular diseases (CVD). Structural and functional aberrations of mitochondria have been observed in CVD. The significance of mitochondrial maturation and function in cardiomyocytes is distinguished by their attribution to embryonic stem cell differentiation into ...
Shekar Kiran - - 2014
Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory failure in adult patients who fail conventional treatment. ECLS also complements cardiac surgical and cardiology procedures, implantation of long-term mechanical cardiac assist devices, heart and lung transplantation and ...
Kritzer Michael D MD 1Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, - - 2014
-Cardiac myocyte hypertrophy is regulated by an extensive intracellular signal transduction network. In vitro evidence suggests that the scaffold protein muscle A-kinase Anchoring Protein (mAKAPβ) serves as a nodal organizer of hypertrophic signaling. However, the relevance of mAKAPβ signalosomes to pathological remodeling and heart failure in vivo remains unknown. -Employing ...
McCullough Peter A - - 2014
Abstract Heart failure is a complex mechanical and neurohormonal syndrome where the left ventricle fails as a pump, resulting in stasis of blood in the lungs and the periphery resulting in the cardial features of effort intolerance, fatigue, and peripheral edema. As part of the neurohormonal and local mechanical strain, ...
Nadruz W W Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, - - 2014
Left ventricular (LV) hypertrophy and remodeling are frequently seen in hypertensive subjects and result from a complex interaction of several hemodynamic and non-hemodynamic variables. Although increased blood pressure is considered the major determinant of LV structural alterations, ethnicity, gender, environmental factors, such as salt intake, obesity and diabetes mellitus, as ...
Koyama S S Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, - - 2014
The circulating osteoprotegerin (OPG) level reflects a series of cardiovascular diseases; however, the source(s) of circulating OPG remain(s) to be determined. This study explored whether OPG is released in the coronary circulation and whether it is associated with cardiac structure and function. Fifty-six patients (67±10 years old, male 57%, hypertension ...
Hoshide Satoshi S Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, - - 2014
Although both high-sensitivity cardiac troponin T (Hs-cTnT) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels are higher among patients with cardiac structural abnormalities than among those with apparently normal hearts, there is considerable overlap between the groups. The authors evaluated 1336 patients who had ≥1 cardiovascular risk factors, underwent echocardiography, and ...
Barbhaiya Chirag C Brigham and Women's Hospital, Boston, - - 2014
Entrainment criteria for macroreentrant arrhythmias are based on detecting fusion between tachycardia and paced wavefronts, but this is often difficult for atrial tachycardias (AT) after ablation of atrial fibrillation. Using a multipolar catheter, pacing was performed from electrodes within the coronary sinus showing activation later than adjacent electrodes (downstream overdrive ...
Angelini Annalisa A Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Gabelli, 61, 35100, Padua, Italy, - - 2014
Cardiac allograft vasculopathy is regarded as a progressive and diffuse intimal hyperplastic lesion of arteries and veins that leads to insidious vessel narrowing and to allograft ischemic disease, such as acute myocardial infarction or sudden cardiac death. The coronary lesions in transplanted hearts are considered as a particular type of ...
Naqvi Nawazish N Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, - - 2014
It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby causing binucleation and limiting regenerative repair after injury. This suggests that heart growth should occur entirely by cardiomyocyte hypertrophy during preadolescence when, in mice, cardiac mass increases many-fold over a few weeks. Here, we show that a thyroid ...
El-Khuffash Afif F AF Department of Pediatrics, The Rotunda Hospital, Dublin, - - 2014
To compare differences in tissue Doppler imaging, global longitudinal strain (GLS), and cardiac troponin T (cTnT) between infants with low (<200 mL/kg/min) and high (>200 mL/kg/min) left ventricular (LV) output 1 hour after duct ligation and assess the impact of milrinone treatment on cardiac output and myocardial performance. LV function was assessed preoperatively ...
Zhao Ying-Zheng YZ Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, - - 2014
Diabetic cardiomyopathy (DCM) is the leading cause of morbidity and mortality among the diabetic patients and currently there is no effective means to reverse its pathological progress. Basic fibroblast growth factor (bFGF) has shown promise as a molecular therapy for DCM, but its delivery is inefficient and non-specific. In the ...
Misra Chaitali C Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's - - 2014
Mutations in GATA4 and TBX5 are associated with congenital heart defects in humans. Interaction between GATA4 and TBX5 is important for normal cardiac septation, but the underlying molecular mechanisms are not well understood. Here, we show that Gata4 and Tbx5 are co-expressed in the embryonic atria and ventricle, but after ...
Biesemann Nadine N Cardiac Development and Remodeling, Max-Planck-Institute of Heart and Lung - - 2014
Myostatin is a major negative regulator of skeletal muscle mass and initiates multiple metabolic changes including enhanced insulin sensitivity. However, the function of Myostatin in the heart is barely understood although it is upregulated in the myocardium in several pathological conditions. Here, we aimed to decipher the role of Myostatin ...
Patel Hitesh C HC Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, - - 2014
To determine the impact of internationally recognized criteria for the diagnosis of heart failure with preserved ejection fraction (HF-PEF) on the feasibility of recruitment into a HF-PEF trial. We reviewed the medical records of 5883 consecutive patients admitted with heart failure across eight hospitals in the UK. From those who ...
Lin Haiyan H Department of Cardiology, Second Affiliated Hospital, Zhejiang University, College of - - 2014
Although cardiac resynchronization therapy (CRT) is a well-established treatment for a subset of patients with chronic heart failure, a considerable proportion of eligible patients still fail to benefit from this treatment. The aim of this study was to identify potential independent predictors for being a responder to CRT. A single-center, ...
Hösch Olga O 1Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University, Göttingen, - - 2014
-The classification of clinical severity of Ebstein's Anomaly (EA) still remains a challenge. The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically -supposedly- normal left heart and to derive from cardiac magnetic resonance (CMR) a simple imaging measure for ...
Kakogawa Jun J Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, - - 2014
Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening condition. The current definition of PPCM only includes patients with systolic dysfunction. We describe a 25-year-old nulligravid patient with heart failure, i.e. left ventricular diastolic dysfunction with preserved systolic dysfunction during the third trimester of pregnancy. She complained of dyspnea and ...
Mathew Paul G PG Department of Neurology, John R. Graham Headache Center, Brigham and Women's Hospital, Boston, MA, USA; Division of Neurology, Cambridge Health Alliance, Cambridge, MA, USA; Harvard Medical School, Boston, MA, - - 2014
The practice of headache medicine is challenging, and excluding secondary causes of headaches is essential for proper diagnosis and treatment. The evaluation of secondary headaches often leads to investigations involving organ systems other than the nervous system. As such, headache, which is typically thought to be neurologic in origin, can ...
Vasile Vlad C VC aDivision of Cardiovascular Diseases, Department of Medicine bDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, - - 2014
Acute cardiac conditions such as acute myocardial infarction and heart failure are associated with significant morbidity and mortality. Rapid diagnosis allows risk stratification and initiation of treatment in a timely manner. Numerous novel biomarkers have been identified to predict outcomes. These may assist in tailoring of appropriate therapy to high-risk ...
Lin Zhiqiang Z Department of Cardiology, Children's Hospital Boston, - - 2014
The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway ...
Toeg Hadi Daood HD Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, - - 2014
Aortic valve (AV) repair (AVr) has become an attractive alternative to AV replacement for the correction of aortic insufficiency; however, little clinical evidence exists in determining which biomaterial at AVr would be optimal. Cusp replacement in AVr has been associated with increased long-term AVr failure. We measured the hemodynamic and ...
Gishto Arsela A Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH, 44115, - - 2014
A major onset of heart failure is myocardial infarction, which causes the myocardium to lose cardiomyocytes and transform into a scar tissue. Since mammalian infarcted cardiac tissue has a limited ability to regenerate, alternative strategies including implantation of tissue-engineered scaffolds at the site of damaged myocardium have been explored. The ...
Ning Bin B School of Graduate, HeBei Medical University, Shi Jia Zhuang, - - 2014
Objective: To compare the effects of biventricular electrical pacing and conventional single-ventricular pacing for cardiac contractility modulation (CCM) on cardiac contractile function and to delineate the underlying molecular mechanisms. Methods : Forty rabbits were divided into four groups before surgery: healthy control, HF sham, HF left ventricular pacing CCM (LVP-CCM), ...
Han B Kelly BK Advanced Cardiac Imaging, Minneapolis Heart Institute and Foundation, Minneapolis, Minn; Division of Cardiology and Cardiothoracic Surgery, Children's Heart Clinic, Minneapolis, Minn; Children's Hospitals and Clinics of Minnesota, Minneapolis, Minn. Electronic address: - - 2014
To assess the accuracy and risk of substituting cardiac computed tomography for cardiac catheterization in select patients for evaluation of anatomy before second-stage single ventricle palliation. This is a retrospective review of consecutive diagnostic cardiac catheterization (n = 16) and computed tomography studies (n = 16) performed before second-stage single ventricle palliation from March ...
Song Xiaole X The First Hospital of China Medical University, Department of Cardiovascular Ultrasound, Shenyang, 110001, - - 2014
A left atrial myxoma was found and removed in a 47-year-old woman admitted for acute ischemic cerebrovascular disease, without family history of cardiac tumor. Follow-up echocardiography, 15 months later, demonstrated a new myxoma in the left ventricle. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014.
Noppe Gauthier G Institut de Recherche Expérimentale et Clinique, Pôle de Recherche Cardiovasculaire, Université catholique de Louvain, Brussels, Belgium. Electronic address: - - 2014
Cardiac fibroblasts (CF) are crucial in left ventricular (LV) healing and remodelling after myocardial infarction (MI). They are typically activated into myofibroblasts that express alpha-smooth muscle actin (α-SMA) microfilaments and contribute to the formation of contractile and mature collagen scars that minimize the adverse dilatation of infarcted areas. CF predominantly ...
Oksanen Tuomas T Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. Electronic address: - - 2014
To evaluate the incidence of postresuscitation myocardial depression (PRMD) and haemodynamical parameters associated with PRMD in patients treated with therapeutic hypothermia (TH) after out-of-hospital cardiac arrest with ventricular fibrillation (OHCA-VF). Analysis of haemodynamical data from computerized clinical databases of two academic ICUs during two year period. We analyzed haemodynamical data ...
Faiz Kashif Waqar - - 2014
A proportion of patients with acute ischemic stroke have elevated cardiac troponin levels and ECG changes suggestive of cardiac injury, but the etiology is unclear. The aims of this study were to assess the frequency of high sensitivity cardiac troponin T (hs-cTnT) elevation, to identify determinants and ECG changes associated ...
de Boer Rudolf A RA Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands, - - 2014
Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure. However, as galectin-3 is ...
Hijazi Ziad Z Department of Cardiology, Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, , Uppsala, - - 2014
To evaluate the prognostic importance of transient or persistent elevations of cardiac troponin-I (cTnI) and N-terminal-B-type natriuretic peptide (NT-proBNP) in atrial fibrillation (AF). Plasma samples were obtained at randomisation and after 3 months in 2514 patients with AF in the RE-LY trial; median follow-up was 2.0 years. Patients were grouped ...
Kuwahara Mieko M Kureha Corporation, Adsorptive Medicine Technology Center, Tokyo, Japan; Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan. Electronic address: - - 2014
Chronic kidney disease (CKD) is associated with increased risks of cardiovascular morbidity and mortality. Cardiac remodeling including myocardial fibrosis and hypertrophy is frequently observed in CKD patients. In this study, we investigate the mechanism involved in cardiac hypertrophy associated with CKD using a rat model, by morphological and chemical component ...
Haugaa Kristina H KH The University of Pittsburgh, Pittsburgh, - - 2014
Risk factors for ventricular arrhythmias after cardiac resynchronization defibrillator therapy (CRT-D) for severely symptomatic heart failure are of clinical importance but are not clearly defined. The objective of this study was to test the hypothesis that mechanical dyssynchrony after CRT-D is a risk factor for ventricular arrhythmias. A total of ...
Deng Wei W Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. - - 2014
Cardiac remodeling is a major determinant of heart failure characterized by cardiac hypertrophy and fibrosis. Sanguinarine exerts widespread pharmacological effects, including antitumor and anti‑inflammatory responses. In the present study, the effect of sanguinarine on cardiac hypertrophy, fibrosis and heart function was determined using the model induced by aortic banding (AB) ...
Sardar Muhammad Rizwan - - 2014
Carney complex is a multiple neoplasia syndrome involving cardiac, endocrine, neural and cutaneous tumors with a variety of pigmented skin lesions. It has an autosomal dominant mode of inheritance. Approximately 7% of cardiac myxomas are related to the Carney complex. Myxomas that occur as part of the Carney complex affect ...
Wang Xiaoyan X Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. - - 2014
Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can ...
Khouzam Rami N RN Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN, - - 2014
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. Patients may present with a wide variety of symptoms, ranging from relatively asymptomatic to heart failure, recurrent syncope, angina, or sudden death. Once diagnosed, a thorough clinical, anatomic and physiologic assessment should be undertaken. Treatment options include both pharmacologic and ...
Panovsky Roman R From the *Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's Faculty Hospital and Masaryk University, Brno, Czech Republic; †Department of Interventional Radiology, Hospital Trinec-Podlesi, Trinec, Czech Republic; ‡Department of Medical Imaging, St. Anne's Hospital, Masaryk University, Brno, Czech Republic; and §Institute of Normal and Pathological Physiology and Center of Excellence for Regulatory Role of Nitric Oxide in Civilization Diseases, Slovak Academy of Sciences, Bratislava, Slovak - - 2014
Cardiovascular magnetic resonance using late gadolinium enhancement (LGE) provides a unique opportunity to assess myocardial tissue in vivo. LGE enables tissue characterization in ischemic and nonischemic cardiomyopathies and other cardiac diseases. LGE is associated with adverse clinical outcomes across a range of different cardiac conditions and may improve risk stratification ...
Mao Song Shou SS Los Angeles Biomedical Research Institute at Harbor-UCLA, 1124 West Carson St, Torrance, CA - - 2014
The cardiac chamber volumes and functions can be assessed manually and automatically using the current computed tomography (CT) workstation system. We aimed to evaluate the accuracy and precision and to establish the reference values for both segmentation methods using cardiac CT angiography (CTA). A total of 134 subjects (mean age ...
Waller Alfonso H AH Non-Invasive Cardiovascular Imaging Program, Department of Medicine (Cardiovascular Division) and Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2014
The noninvasive detection of the presence and functional significance of coronary artery stenosis is important in the diagnosis, risk assessment, and management of patients with known or suspected coronary artery disease. Quantitative assessment of myocardial perfusion can provide an objective and reproducible estimate of myocardial ischemia and risk prediction. Positron ...
Padeletti Margherita M aDepartment of Cardiovascular Diseases, University of Siena, Siena, Italy bDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, - - 2014
Sleep-disordered breathing (SDB) has been consistently associated with increased risk for cardiovascular diseases, including arrhythmias. The purpose of this review is to elucidate the several pathophysiologic pathways such as repetitive hypoxia and reoxygenation, increased oxidative stress, inflammation and sympathetic activation that may underlie the increased incidence of arrhythmias in SDB ...
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