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Schultz Carlee D CD Centre for Heart Rhythm Disorders, University of Adelaide and Cardiovascular Investigation Unit, Royal Adelaide Hospital, Adelaide, - - 2014
Patients with atrial fibrillation (AF) are at an increased risk of thromboembolism and stroke primarily from the development of thrombi within the left atrial. Pathological changes in blood constituents and atrial endothelial damage promote the left atrial thrombus formation. It is not known whether factors predisposing to left atrial thrombus ...
Zamani Payman P Division of Cardiovascular Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, - - 2014
Atrial fibrillation remains the most prevalent cardiac arrhythmia, and its incidence is increasing as the population ages. Common conditions associated with an increased incidence include advanced age, hypertension, heart failure, and valvular heart disease. Patients with atrial fibrillation may complain of palpitations, fatigue, and decreased exercise tolerance or may be ...
Rotter David D Departments of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA. Electronic address: - - 2014
Many important components of the cardiovascular system display circadian rhythmicity. In both humans and mice, cardiac damage from ischemia/reperfusion (I/R) is greatest at the transition from sleep to activity. The causes of this window of susceptibility are not fully understood. In the murine heart we have reported high amplitude circadian ...
Haldar Saptarsi M SM Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA. Electronic address: - - 2014
Studies of transcriptional mechanisms in heart failure have focused heavily on roles of sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4. Recent findings have illuminated crucial functions for epigenetic regulators in the control of cardiac structural remodeling and mechanical dysfunction in response to pathological stress. Here, we review the ...
Xing Rui R Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, - - 2014
Myocardial contractility is crucial for cardiac output and heart function. But the detailed mechanisms of regulation remain unclear. In the present study, we found that HIP-55, an actin binding protein, negatively regulates myocardial contractility at the single-cell level. HIP-55 was overexpressed and knocked down in cardiomyocytes with an adenovirus infection. ...
Chen-Scarabelli Carol C Veterans Affairs Ann Arbor Health Care System, University of Michigan, Ann Arbor, - - 2014
The present study investigated the cardioprotective role of urocortin (Ucn) and its relationship with protein kinase C (PKC)ε and PKCδ in patients with (DMPs) and without (NDMPs) diabetes mellitus after on-pump cardiac surgery (OPCS). The molecular mechanisms responsible for the reported worse outcomes of DMP after OPCS remain unknown. Two ...
Yüksel Ramazan R 1 Gulhane Military Medical Academy, Ankara, - - 2014
Summary.-Previous studies reported reduced longevity in left-handers with the suggestion that it may be associated with different heart diseases. Therefore, differences in heart rate variability (HRV), an index of autonomic cardiac activity, were examined for right- and left-handed individuals. 120 healthy young university students (75 women, 45 men; M age ...
Gimelli Alessia A Fondazione CNR/Regione Toscana, Via Moruzzi, 1, 56124, Pisa, Italy, - - 2014
To assess the relationships between myocardial structure and function on cardiac magnetic resonance (CMR) imaging and sympathetic tone on (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy early after myocardial infarction (MI). Ten patients underwent (123)I-MIBG and (99m)Tc-tetrofosmin rest cadmium zinc telluride scintigraphy 4 ± 1 days after MI. The segmental left ventricular (LV) relative radiotracer uptake of ...
Bharucha Tara T 1 Department of Paediatric Cardiology, University Hospital Southampton NHS Foundation Trust, United - - 2014
It is frequent, in the current era, to encounter congenital cardiac malformations described in terms of "cor triatriatum". But can hearts be truly found with three atrial chambers? The morphological method, emphasised by Van Praagh et al, states that structures within the heart should be defined on the basis of ...
Slagsvold Katrine Hordnes KH St. Olav's University Hospital / Norwegian University of Science and Technology - - 2014
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a potential to cause serious complications. Mitochondria play central roles in cardiomyocyte function, and have been implicated in AF pathophysiology. MicroRNA (miR) are suggested to influence both mitochondrial function and the development of AF. Yet mitochondrial function and miR expression ...
Chhabra Lovely L Departments of Internal Medicine and Saint Vincent Hospital, University of Massachusetts Medical School, Worcester, MA, USA. - - 2014
Interatrial block (IAB; P-wave duration ≥ 110 ms), which represents a delay in the conduction between the atria, is a pandemic conduction abnormality that is frequently underappreciated in clinical practice. Despite its comprehensive documentation in the medical literature, it has still not received adequate attention and also not adequately described ...
Ma Xuefei X Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD - - 2014
-The three isoforms of nonmuscle myosin II (NMII-A, NMII-B and NMII-C) play various roles during mouse embryonic development. Previous work, using knockout and hypomorphic mice, showed that MYH10 encoding myosin heavy chain II-B is critical for cardiac and brain development. Ablating or decreasing NMII-B by 80% results in cardiac (ventricular ...
Popovic Batric B 1CHU Nancy, Service de Cardiologie Médicale; Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois; 54511 Vandoeuvre les Nancy, France 2INSERM, Centre d'Investigation Clinique CIC-P 9501, Nancy, France. 3CHU Nancy, Service de Réanimation Médicale; Pole Urgences-Réanimation Médicale, Hopital Central, 54000 Nancy 4CHU Nancy, Service de Réanimation Médicale Brabois Médicale; Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois; 54511 Vandoeuvre les Nancy, France 5INSERM, Groupe Choc, U1116, Faculté de Médecine, 54511 Vandoeuvre les Nancy, France 6Université de Lorraine, 54000, Nancy - - 2014
Short-term prognostic factors in patients with cardiogenic shock (CS) have previously been established using only hemodynamic parameters without taking into account classical ICU severity score or organ failure/support. The aim of this study was to assess early predictors of in-hospital mortality of a monocentric cohort of patients with ST-elevation myocardial ...
Chiale Pablo A PA Centro de Arritmias Cardíacas de la Ciudad Autónoma de Buenos Aires. Cardiology Division. Hospital J.M. Ramos Mejía. Buenos Aires. Argentina. - - 2014
T wave "memory" is a peculiar variety of cardiac remodeling caused by a transient change in the course of ventricular depolarization (due to ventricular pacing, rate-dependent intraventricular block, ventricular preexcitation or tachyarrhythmias with wide QRS complexes). It is usually manifested by inverted T waves that appears when normal ventricular activation ...
Jain Rahul - - 2014
Various noninvasive tests for risk stratification of sudden cardiac death (SCD) were studied, mostly in the context of structural heart disease such as coronary artery disease (CAD), cardiomyopathy and heart failure but have low positive predictive value for SCD. Fragmented QRS complexes (fQRS)on a 12-lead ECG is a marker of ...
Ingec Muharrem M 1 Department of Nephrology, School of Medicine, Harran University, Sanliurfa - - - 2014
Cardiac troponins are specific and sensitive markers of myocardial damage. Troponin levels may increase without an obvious active cardiac disease in hemodialysis patients. In this study, we aimed to investigate the effect of a single hemodialysis session on echocardiographic parameters and cardiac enzyme levels, including cTn-I, creatine phosphokinase (CPK), and ...
Mazzone Carmine C Cardiovascular Center, Health Authority n° 1, Trieste, - - 2014
In patients with chronic pressure overload, higher left atrial systolic force (LASF) is associated with high-risk cardiovascular (CV) phenotype, with increased left ventricular (LV) mass, concentric hypertrophy, and diastolic dysfunction. In hypertension and aortic stenosis, LASF predicts increased rate of CV events independent of traditional risk factors. Moreover, LASF is ...
Wu Jian J Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan - - 2014
In the heart, mechanical load is a crucial regulator of myocardial structure and function; however, mechanical overload is a pathogenesis or comorbidity existing in a variety of heart diseases, such as hypertension, aortic regurgitation and myocardial infarction. Mechanical overload can be generally differentiated into 2 types, pressure overload (PO) and ...
Tare Marianne - - 2014
Intrauterine inflammation is a major contributor to preterm birth and has adverse effects on preterm neonatal cardiovascular physiology. Cardiomyocyte maturation occurs in late gestation in species such as humans and sheep. We tested the hypothesis that intrauterine inflammation has deleterious effects on cardiac function in preterm sheep which might be ...
Ellims Andris H AH Heart Centre, Alfred Hospital, Melbourne, - - 2014
In hypertrophic cardiomyopathy (HCM), attempts to associate genotype with phenotype have largely been unsuccessful. More recently, cardiac magnetic resonance (CMR) imaging has enhanced myocardial fibrosis characterization, while next-generation sequencing (NGS) can identify pathogenic HCM mutations. We used CMR and NGS to explore the link between genotype and fibrotic phenotype in ...
Zafiropoulos A A 1Department of Histology-Embryology, Medical School, University of Crete, Heraklion, Crete, - - 2014
Lethal cardiac complications leading to death and various arrhythmias have been reported after organophosphate and/or carbamate poisonings. The present study focuses on the long-term effects of repeated low-level exposure to diazinon, propoxur, and chlorpyrifos (CPF) on cardiac function in rabbits. The yearly based experimental scheme of exposure consisted of two ...
Slack J J Department of Clinical Studies, New Bolton Center, University of Pennsylvania, 382 West Street Road, Kennett Square, PA, 19348, - - 2014
Cardiac arrhythmias are a recognised but poorly characterised problem in the Standardbred racehorse. Frequency data could aid the development of cardiac arrhythmia screening programs. To characterise the occurrence of cardiac arrhythmias in Standardbreds prior to racing and in the late post-race period using a hand-held, non-continuous recording device. Prospective, observational ...
Zeriouh Mohamed - - 2014
The aim of this prospective observational study was to evaluate the efficiency of a new escalating treatment strategy with vernakalant, flecainide and electrical cardioversion (EC) in patients with new onset atrial fibrillation (AF) after cardiac surgery. 24 patients with new onset AF after aortic valve surgery, coronary artery bypass surgery ...
Lu Ming-Jen MJ Department of Cardiovascular Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, - - 2014
Hypoxic preconditioning (HPC) protects rat hearts against ischemia-reperfusion (IR) injury. However, the role of transient receptor potential vanilloid 1 (TRPV1) in HPC-mediated cardioprotection remains unknown. TRPV1 is activated by endovanilloid 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], which is synthesized by arachidonate 12-lipoxygenase (ALOX12). Therefore, we examined whether HPC protects the myocardium against IR ...
Basavarajaiah Sandeep S Interventional Cardiology Unit, EMO-GVM Centro Cuore Columbus, Milan, Italy; Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy; Interventional Cardiology Unit, The Heart of England Trust, Birmingham, United Kingdom; Interventional Cardiology Unit, Imperial College, London, United - - 2014
To report a single-center experience of drug-eluting balloons (DEB) in the treatment of in-stent restenosis (ISR) and de novo coronary artery disease. DEB are emerging as an alternative treatment for coronary stenosis especially when metal scaffolding is undesirable (in-stent restenosis and small-vessel de novo disease). Although there are various randomized ...
Uchinaka Ayako A Osaka University Graduate School of Medicine, Departments of Molecular Pathology, Osaka, Japan ; - - 2014
Matrix metalloproteinases (MMPs) and a family of tissue inhibitors of metalloproteinases (TIMPs) may contribute to myocardial remodeling in heart failure. TIMPs are the main inhibitors of MMPs and have other MMP-independent functions. Because little is known of the role of TIMPs in the heart, we examined the effects of TIMPs ...
Rodriguez Fatima F Department of Medicine, Brigham and Women's Hospital, Boston, - - 2014
We report the case of a 67-year-old man with hypertrophic cardiomyopathy who presented for a second opinion about implantable cardio-defibrillator (ICD) placement after a witnessed syncopal episode. Despite his older age, being mutation-negative, and having a maximal septal thickness of 2.2 cm on echocardiography, he demonstrated rapid progression of myocardial fibrosis ...
Zhu Ming-Jun MJ Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China, - - 2014
To evaluate the effects of Jiashen Prescription (, JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats. One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were ...
Bisplinghoff S S Chair of Medical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 , Aachen, Germany, - - 2014
 Identification of viable myocardial tissue is important for patients with a low left ventricular ejection fraction, since revascularization is effective only if the affected region is viable. After cineangiographic identification of occluded coronary vessels, the myocardial viability is usually determined using cardiac MRI or SPECT. Alternatively, myocardial deformation imaging by ...
Spiewak M M Magnetic Resonance Unit, Institute of Cardiology, Warsaw, Poland; Department of Radiology, Institute of Cardiology, Warsaw, Poland; Department of Coronary Artery Disease and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. Electronic address: - - 2014
To assess the relationship between cardiothoracic ratio (CTR) and ventricular and atrial volumes in patients with repaired tetralogy of Fallot (TOF). Patients with repaired TOF undergoing cardiac magnetic resonance (CMR) and chest radiography within 1 day were included (n = 82; median age: 24.7 years, interquartile range: 21.5-35.9). The CTR was obtained ...
Cavalera Michele M Division of Cardiology, Department of Medicine, The Wilf Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New - - 2014
Cardiac fibrosis is strongly associated with obesity and metabolic dysfunction and may contribute to the increased incidence of heart failure, atrial arrhythmias, and sudden cardiac death in obese subjects. This review discusses the evidence linking obesity and myocardial fibrosis in animal models and human patients, focusing on the fundamental pathophysiological alterations ...
Perdreau Elodie E Service de Cardiologie Congénitale et Pédiatrique, Hôpital du Haut-Lévêque, CHU Bordeaux, Avenue de Magellan, 33604, Pessac, France, - - 2014
Tramadol is a common analgesic, widely prescribed because of its efficiency and safety. We report the case of a 7-year-old child admitted in cardiac intensive care unit for cardiogenic shock due to tramadol intoxication. Without any past history, the child was admitted at emergency room for generalised convulsion, followed by ...
Lo K Y KY Division of Cardiology, Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong - - 2014
OBJECTIVE. To evaluate the intermediate-term outcomes of patients with unprotected left main coronary artery stenosis who were treated with percutaneous coronary intervention in Hong Kong. DESIGN. Historical cohort. SETTING. A regional hospital in Hong Kong. PATIENTS. Patients with unprotected left main coronary artery disease undergoing stenting with bare-metal stents or ...
Gomes Katia M S KM Department of Anatomy, Institute of Biomedical - - 2014
We previously demonstrated that pharmacological activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion injury. Here we determined the benefits of chronic activation of ALDH2 on the progression of heart failure using a post-myocardial infarction model.Methods and ResultsWe showed that a six-week treatment of myocardial infarction-induced ...
Osbourne Appledene A University of Chicago Institute for Cardiovascular Research, 5841S. Maryland Ave, MC 6080, Chicago, IL 60637. Electronic address: - - 2014
MicroRNAs (miRNAs) are now recognized as critical regulators of diverse physiological and pathological processes; however, studies of miRNAs and arrhythmogenesis remain sparse. Connexin43 (Cx43), a major cardiac gap junction protein, has elicited great interest in its role in arrhythmias. Additionally, Cx43 was a potential target for miR-130a as predicted by ...
Nishiuchi Tatsuya T Department of Acute Medicine, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan. Electronic address: - - 2014
The present study aimed to clarify the incidence and outcomes of sudden cardiac arrests in schools and the clinically relevant characteristics of individuals who experienced sudden cardiac arrests. We obtained data on sudden cardiac arrests that occurred in schools between January 1, 2005 and December 31, 2009 from the database ...
Zellweger Michael J MJ Division of Cardiology, University Hospital, Basel, Switzerland. Electronic address: - - 2014
This study sought to evaluate the prognostic value of routine stress myocardial perfusion scintigraphy (MPS) 5 years after percutaneous coronary intervention (PCI). Current appropriate use criteria define routine cardiac stress imaging <2 years after PCI as inappropriate and >2 years as uncertain in asymptomatic patients. All 339 of 683 BASKET ...
Lee Ki Hong KH Chonnam National University Hospital, Gwangju, South - - 2014
Cardiac arrest complicating acute ST elevation myocardial infarction (STEMI) is known to be associated with increased in-hospital mortality. However, little is known about the long-term outcomes after cardiac arrest complicating first onset STEMI in contemporary percutaneous coronary intervention (PCI) era. We analyzed 7942 consecutive patients who were diagnosed with STEMI ...
Givvimani Srikanth S Department of Physiology & Biophysics, School of Medicine, University of Louisville, KY 40202, - - 2014
Therapeutic approaches for cardiac regenerative mechanisms have been explored over the past decade to target various cardiovascular diseases (CVD). Structural and functional aberrations of mitochondria have been observed in CVD. The significance of mitochondrial maturation and function in cardiomyocytes is distinguished by their attribution to embryonic stem cell differentiation into ...
Shekar Kiran - - 2014
Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory failure in adult patients who fail conventional treatment. ECLS also complements cardiac surgical and cardiology procedures, implantation of long-term mechanical cardiac assist devices, heart and lung transplantation and ...
Kritzer Michael D MD 1Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, - - 2014
-Cardiac myocyte hypertrophy is regulated by an extensive intracellular signal transduction network. In vitro evidence suggests that the scaffold protein muscle A-kinase Anchoring Protein (mAKAPβ) serves as a nodal organizer of hypertrophic signaling. However, the relevance of mAKAPβ signalosomes to pathological remodeling and heart failure in vivo remains unknown. -Employing ...
McCullough Peter A - - 2014
Abstract Heart failure is a complex mechanical and neurohormonal syndrome where the left ventricle fails as a pump, resulting in stasis of blood in the lungs and the periphery resulting in the cardial features of effort intolerance, fatigue, and peripheral edema. As part of the neurohormonal and local mechanical strain, ...
Nadruz W W Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, - - 2014
Left ventricular (LV) hypertrophy and remodeling are frequently seen in hypertensive subjects and result from a complex interaction of several hemodynamic and non-hemodynamic variables. Although increased blood pressure is considered the major determinant of LV structural alterations, ethnicity, gender, environmental factors, such as salt intake, obesity and diabetes mellitus, as ...
Koyama S S Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, - - 2014
The circulating osteoprotegerin (OPG) level reflects a series of cardiovascular diseases; however, the source(s) of circulating OPG remain(s) to be determined. This study explored whether OPG is released in the coronary circulation and whether it is associated with cardiac structure and function. Fifty-six patients (67±10 years old, male 57%, hypertension ...
Hoshide Satoshi S Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, - - 2014
Although both high-sensitivity cardiac troponin T (Hs-cTnT) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels are higher among patients with cardiac structural abnormalities than among those with apparently normal hearts, there is considerable overlap between the groups. The authors evaluated 1336 patients who had ≥1 cardiovascular risk factors, underwent echocardiography, and ...
Barbhaiya Chirag C Brigham and Women's Hospital, Boston, - - 2014
Entrainment criteria for macroreentrant arrhythmias are based on detecting fusion between tachycardia and paced wavefronts, but this is often difficult for atrial tachycardias (AT) after ablation of atrial fibrillation. Using a multipolar catheter, pacing was performed from electrodes within the coronary sinus showing activation later than adjacent electrodes (downstream overdrive ...
Angelini Annalisa A Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Gabelli, 61, 35100, Padua, Italy, - - 2014
Cardiac allograft vasculopathy is regarded as a progressive and diffuse intimal hyperplastic lesion of arteries and veins that leads to insidious vessel narrowing and to allograft ischemic disease, such as acute myocardial infarction or sudden cardiac death. The coronary lesions in transplanted hearts are considered as a particular type of ...
Naqvi Nawazish N Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, - - 2014
It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby causing binucleation and limiting regenerative repair after injury. This suggests that heart growth should occur entirely by cardiomyocyte hypertrophy during preadolescence when, in mice, cardiac mass increases many-fold over a few weeks. Here, we show that a thyroid ...
El-Khuffash Afif F AF Department of Pediatrics, The Rotunda Hospital, Dublin, - - 2014
To compare differences in tissue Doppler imaging, global longitudinal strain (GLS), and cardiac troponin T (cTnT) between infants with low (<200 mL/kg/min) and high (>200 mL/kg/min) left ventricular (LV) output 1 hour after duct ligation and assess the impact of milrinone treatment on cardiac output and myocardial performance. LV function was assessed preoperatively ...
Zhao Ying-Zheng YZ Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, - - 2014
Diabetic cardiomyopathy (DCM) is the leading cause of morbidity and mortality among the diabetic patients and currently there is no effective means to reverse its pathological progress. Basic fibroblast growth factor (bFGF) has shown promise as a molecular therapy for DCM, but its delivery is inefficient and non-specific. In the ...
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