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Rodrigo Miguel M BIO-ITACA, Universitat Politècnica de València, Edificio 8G, Camino de Vera, S/N, 46022, Valencia, - - 2015
Cardiac arrhythmias are an increasingly present in developed countries and represent a major health and economic burden. The occurrence of cardiac arrhythmias is closely linked to the electrical function of the heart. Consequently, the analysis of the electrical signal generated by the heart tissue, either recorded invasively or noninvasively, provides ...
Mai Jingting J Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, - - 2014
Neovascularization plays pivotal role in ischemic heart failure; however, it is unclear in non-ischemic heart failure. Non-ischemic heart failure was induced by chronic rapid right ventricular pacing at 200 beats/min, respectively, for 3 and 6 weeks in 12 dogs. Sham-operation was performed in another 6 dogs as control. Three-week tachycardia pacing ...
Halvorsen Cecilia Pegelow CP Department of Clinical Science and Education, Karolinska Institutet, Stockholm, - - 2014
Intrauterine laser treatment is used to alleviate abnormal circulatory load and cardiac morbidity affecting fetuses with twin-twin transfusion syndrome (TTTS). We conducted this childhood follow-up study to fill the gap in knowledge about final cardiac outcomes after such interventions. We investigated 19 TTTS pairs - 11 male and eight female ...
Barold S Serge SS Florida Heart Rhythm Institute, 5 Tampa General Circle, 33606, Tampa, FL, USA, - - 2014
A number of trials have shown that irrespective of baseline QRS duration, left ventricular (LV) dysfunction and heart failure are more common in patients with right ventricular (RV) than in those with biventricular (BiV) pacing. By contrast, preliminary results of the BIOPACE trial (follow-up 5.6 years) yielded a disappointing comparison of ...
Osca Joaquín J Electrophysiology Section, Cardiology Department, Hospital Universitari i Politècnic La Fe, Valencia, - - 2014
The objective of the present study was to evaluate the usefulness of a left ventricle (LV) quadripolar lead in improving the hemodynamic response to cardiac resynchronization therapy (CRT). We included 27 consecutive patients implanted with a CRT device with an LV quadripolar lead. Hemodynamic parameters were evaluated at 3-month follow-up ...
Ota Kyle K John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii; - - 2014
Low-energy blunt chest trauma can cause commotio cordis and ventricular fibrillation (VF) in otherwise healthy young individuals. If the chest wall impact occurs during a narrow vulnerable window of ventricular repolarization, the generated premature ventricular impulse can lead to VF and sudden death. Atrial fibrillation (AF) in association with a ...
Mugnai Giacomo G aHeart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium bDepartment of Cardiology, University Hospital of Verona, Verona, - - 2014
Prolonged P-wave duration and dispersion are universally accepted noninvasive markers for atrial electrical remodeling. Our aim was to analyze P-wave indices as predictors of atrial fibrillation recurrence after pulmonary vein isolation in patients with normal left atrial size. From January 2008 to December 2011, 426 patients with drug-resistant symptomatic paroxysmal ...
Jacob K A KA Department of Anesthesiology and Intensive Care, University Medical Center Utrecht, Mail Stop F.06.149, PO Box 85500, 3508, Utrecht, the Netherlands, - - 2014
Postoperative new-onset atrial fibrillation (PNAF) is very common after cardiac surgery and postoperative inflammation may contribute to PNAF by inducing atrial dysfunction. Corticosteroids reduce inflammation and may thus reduce atrial dysfunction and PNAF development. This study aimed to determine whether dexamethasone protects against left atrial dysfunction and PNAF in cardiac ...
Durak Ilker I Golbasi Hasvak State Hospital, Ankara, - - 2014
The authors reviewed current knowledge on occurrence, clinical and prognostic significance, and management of sustained ventricular arrhythmias, atrial fibrillation and bradyarrhythmias in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary interventions (PCI). Cardiac arrhythmias worsen clinical course and prognosis in patients with ST-elevation myocardial infarction undergoing primary PCI. Sustained ...
Sommer Anders A Department of Cardiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 100, Aarhus N DK-8200, Denmark - - 2014
Paced electrocardiogram characteristics to confirm left ventricular (LV) and right ventricular (RV) pacing sites in cardiac resynchronization therapy (CRT) have not been validated with accurate knowledge of pacing lead positions. We aimed to evaluate the ability of the paced QRS morphology to differentiate between various LV and RV lead positions ...
Meyers Tatyana A TA University of - - 2014
Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant because they result in the leading causes of death in DMD patients. Despite the clinical and physiological significance of these systems, little has been done to understand the cardio-respiratory ...
Lüker Jakob J Department of Electrophysiology, Heart Center, University Hospital Cologne, Kerpener Strasse 62, 50937, Cologne, Germany, - - 2014
Atrial arrhythmias lower the biventricular pacing percentage in cardiac resynchronization therapy (CRT) treated patients (pts) and have a high prevalence in this population. External electrical cardioversion (ECV) is commonly performed to restore sinus rhythm. There is a paucity of data on the safety and efficacy of ECV in pts with ...
Abbas Ausami A Department of Cardiothoracic Radiology University Hospital Southampton Tremona Road, Southampton, United Kingdom. SO16 - - 2014
Microvascular obstruction is usually seen in a proportion of patients with acute myocardial infarction following reperfusion therapy of an occluded coronary artery. It is characterised by damage and dysfunction of the myocardial microvasculature with a no-reflow phenomenon within the infarct zone. While microvascular obstruction may be demonstrated via a number ...
Goudis Christos A CA 1Department of Cardiology, General Hospital of Grevena, Greece 2Department of Cardiology, University Hospital of Ioannina, Greece 3Department of Cardiology, Interbalkan Medical Center, Thessaloniki, - - 2014
Atrial fibrillation is the commonest arrhythmia in athletes and may be associated with endurance sport practice. Atrial ectopic beats, chronic systemic inflammation, autonomic system alterations, anatomic adaptation, myocardial injury and illicit drugs seem to be implicated in the increased prevalence of atrial fibrillation in athletes, but clear evidence is lacking. ...
Nicoara Alina A Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, - - 2014
The review focuses on recent findings on the role of diastolic dysfunction in the perioperative period and on recent advances in the diagnosis and perioperative management of diastolic function. Left ventricular diastolic dysfunction is an underestimated disease with a high risk for acute decompensation in the perioperative period. It has ...
Lau Kelvin C KC Divisions of Cardiology, Departments of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: - - 2014
Multiple cardiac operations and resultant myocardial scarring have been implicated in the overall diminished performance of epicardial pacing systems in patients with congenital heart disease (CHD). We evaluated the long-term permanent epicardial pacing lead survival in patients with CHD who had epicardial lead placement in association with surgical repair or ...
Dong Yu-Mei YM Department of Cardiology, Center for Atrial Fibrillation, Beijing Anzhen Hospital, Capital Medical University , - - 2014
Background. Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating miR-145 concentration. Methods. We assessed 246 patients with first ST-segment-elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured ...
Alkindi Fahad F Department of Cardiology and Cardiovascular Surgery, Heart Hospital, HMC, Doha, - - 2014
Between 1991 and 2013, we evaluated the demographics, presentations, and final diagnosis of patients hospitalized with acute cardiac events and left bundle branch block (LBBB). Of 50 992 patients, 768 (1.5%) had LBBB. Compared with non-LBBB patients, patients with LBBB were mostly older, female, diabetic, and had hypertension and chronic ...
Orvos Péter P Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Dóm tér 12, H-6720 Szeged, Hungary; Rytmion Ltd., Benczúr u. 39, H-6727 Szeged, - - 2014
Chelidonium majus or greater celandine is spread throughout the world, and it is a very common and frequent component of modern phytotherapy. Although C. majus contains alkaloids with remarkable physiological effect, moreover, safety pharmacology properties of this plant are not widely clarified, medications prepared from this plant are often used ...
Silva Rui R Laboratório de Pacing, Serviço de Cardiologia, Hospital de Santarém, EPE, Santarém, Portugal. Electronic address: - - 2014
The aim of this study was to assess the effectiveness of atrial antitachycardia pacing (ATP) in the conversion of atrial tachyarrhythmia episodes, and its impact in reducing arrhythmic burden. We performed a retrospective study in the pacing laboratory of a district hospital of 57 consecutive patients implanted with a dual ...
Grogan Martha M Division of Cardiology, Department of Medicine, Mayo Clinic, Rochester, MN, USA, - - 2014
The natural history of immunoglobulin light chain associated amyloidosis (AL) is determined by the extent of cardiac involvement. Patients with cardiac AL and symptomatic heart failure have a median survival of approximately six months without successful treatment of the underlying plasma cell disorder The outcome in cardiac AL is determined ...
Kaye Gerry G Department of Cardiology, Princess Alexandra Hospital, Woolloongabba and University of Queensland, Brisbane 4102, - - 2014
The right ventricular apex has been the traditional site for lead placement in patients with atrioventricular block. Pacing at the right ventricular apex may have long-term deleterious effects on left ventricular (LV) function, promoting heart failure and increasing mortality. Pacing at the right ventricular septum has been proposed to minimize ...
Andrade Jason G JG Electrophysiology Service, Montreal Heart Institute and the Department of Medicine, Université de Montréal, Montreal, Canada; Department of Medicine, University of British Columbia, British Columbia, - - 2014
The development and evolution of percutaneous catheter ablation for the treatment of cardiac arrhythmias has advanced significantly since the early days of direct current shock ablation, and in parallel with an increasing understanding about arrhythmia mechanisms. Because of the ever-changing landscape that is cardiac electrophysiology, the purpose of this review ...
Urbinati Stefano S Ospedale Bellaria, Department of Cardiology, Bologna, - - 2014
To describe drug adherence and treatment goals, and to identify the independent predictors of smoking persistence and unsatisfactory lifestyle habits six months after an acute myocardial infarction (AMI). 11,706 patients with AMI (30% female, mean age 68 years) were enrolled in 163 large-volume coronary care units (CCUs). At six months, ...
Hijazi Ziad Z Uppsala Clinical Research Center, Department of Medical Sciences, Cardiology, and - - 2014
Although cardiac troponin is associated with outcomes in atrial fibrillation (AF), the complementary prognostic information provided by cardiac troponin I (cTnI) and cTnT is unknown. This study investigated the distribution, determinants, and prognostic value of cTnI and cTnT concentrations in patients with AF. At the time of randomization, we analyzed ...
Mistry Ravin R Anaesthetics Department, University College Hospital NHS Foundation Trust, London, UK - - 2014
Perioperative β-blocker therapy has been advocated to reduce cardiac mortality and morbidity in high-risk cardiac patients undergoing non-cardiac surgery. Core data that supported this intervention and informed international societal guidelines has recently been withdrawn. A subsequent meta-analysis of the remaining data reporting excess mortality has re-opened the debate about the ...
Matrone Gianfranco G 1 British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh , Edinburgh, United Kingdom - - 2014
Abstract Mammalian models of cardiac disease have provided unique and important insights into human disease but have become increasingly challenging to produce. The zebrafish could provide inexpensive high-throughput models of cardiac injury and repair. We used a highly targeted laser, synchronized to fire at specific phases of the cardiac cycle, ...
Liu Hong H Department of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, 1# Tiantan Xili, Beijing 100050, P. R. - - 2014
Physical inactivity during space flight or prolonged bed rest may cause cardiac dysfunction and atrophy, but the exact mechanism that governs the regulation of myocardial dysfunction and cardiac atrophy remains poorly understood. Autophagy, a protein degradation pathway, has recently been shown to be involved in the regulation of cardiac dysfunction ...
Jakovljevic Djordje G DG Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, United Kingdom; RCUK Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: - - 2014
Noninvasive continuous cardiac output monitoring may have wide clinical applications in anaesthesiology, emergency care and cardiology. It can improve outcomes, establish diagnosis, guide therapy and help risk stratification. The present article describes the theory behind the two noninvasive continuous monitoring methods for cardiac output assessment such as bioimpedance and bioreactance. ...
Sentürk Ay┼čegül A Department of Chest Disease, Atatürk Training and Research Hospital, Ankara, - - 2014
Cardiac sarcoidosis is an infiltrative, granulomatous inflammatory disease of the myocardium. Generally, it can be difficult to diagnose cardiac sarcoidosis clinically because of the non-specific nature of its clinical manifestations. This property can be based on the presence of any clinical evidence of sarcoidosis in the other organs. We present ...
Zhou Xue-Liang XL Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, - - 2014
The expression of Hes1 is increased following myocardial infarct and other ischemic cardiomyopathies, but the role of Hes1 in cardioprotection provided by ischemic postconditioning (IPost) remains unclear. In this study, we used gain and loss of function approaches to investigate the role of Hes1 in cardioprotection during IPost. Primary cardiac ...
Han Jie J Department of Cardiovascular Sciences, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, - - 2014
Recent reports have characterized virological and clinical features of the novel re-assortant avian-origin influenza A (H7N9) virus. However, cardiovascular involvement during H7N9 infection is still unclear. In the present study we evaluate cardiac injury among H7N9-infected patients. A total of 40 patients who were laboratory-confirmed with H7N9 infection were retrospectively ...
Joyce Emer E Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Advanced Heart Disease, Brigham and Womens Hospital, Boston, MA, - - 2014
Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. ...
Bergum Daniel D Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Department of Anaesthesia and Intensive Care Medicine, St. Olav University Hospital, Trondheim, Norway; Norwegian Air Ambulance Foundation, Norway. Electronic address: - - 2014
Do emergency teams (ETs) consider the underlying causes of in-hospital cardiac arrest (IHCA) during advanced life support (ALS)? In a 4.5-year prospective observational study, an aetiology study group examined 302 episodes of IHCA. The purpose was to investigate the causes and cause-related survival and to evaluate whether these causes were ...
Claridge Simon S Guy's and St Thomas' Hospital, UK; King's College London, UK. Electronic address: - - 2014
Cardiac resynchronisation therapy (CRT) improves mortality and symptoms in heart failure patients with electromechanically dyssynchronous ventricles. There is a 50% non-response rate and reproducible biomarkers to predict non-response have not been forthcoming. Therefore, there has been increasing interest in the pathophysiological effects of dyssynchrony particularly focusing on coronary flow, myocardial ...
Doerner Jonas M JM Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, - - 2014
To investigate the impact of a caffeine and taurine containing energy drink (ED) on myocardial contractility in healthy volunteers using cardiac MR and cardiac MR based strain analysis. 32 healthy volunteers (mean age 28 years) were investigated before and 1 h after consumption of a caffeine and taurine containing ED. For assessment ...
Papadopoulou Elektra E Department of Clinical Therapeutics, Medical School, University of Athens, "Alexandra" Hospital, Athens, Greece. Electronic address: - - 2014
Right ventricular apical pacing may induce detrimental effects on left ventricular function and coronary flow. In this study, the effects of pacing site and mode on cardiac mechanics and coronary blood flow were evaluated. This prospective study included 25 patients who received dual-chamber pacemakers with the ventricular lead placed in ...
Awad Salma S Cardiovascular Research Program, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh, 11211, Kingdom of Saudi - - 2014
Heart failure is associated with the reactivation of a fetal cardiac gene program which has become a hallmark of cardiac hypertrophy and maladaptive ventricular remodeling. Yet the mechanisms that regulate this transcriptional reprogramming are not fully understood. Using mice with genetic ablation of calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ), which ...
McCabe Pamela J PJ Mayo Clinic, Rochester, MN, - - 2014
To describe patients' experiences from symptom onset to initial treatment for atrial fibrillation. The estimated number of individuals with atrial fibrillation globally in 2010 was 33·5 million. World-wide, each year, new cases of atrial fibrillation approach 5 million, and prevalence will increase 2·5-fold by 2050. As a result, clinicians worldwide will treat ...
Kirchhof Paulus P Department of Cardiovascular Medicine, Hospital of the University of Muenster, Muenster, Germany; University of Birmingham Center for Cardiovascular Sciences, School of Clinical and Experimental Medicine, and SWBH NHS Trust, Birmingham, United Kingdom - - 2014
-New therapeutic approaches to improve cardiac contractility without severe risk would improve the management of acute heart failure. Increasing systolic sodium influx can increase cardiac contractility, but most sodium channel activators have proarrhythmic effects that limit their clinical use. Here, we report the cardiac effects of a novel positive inotropic ...
Nakaoka Mikihiko M Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, - - 2014
Alpha-adrenergic agonists is known to be protective in cardiac myocytes from apoptosis induced by beta-adrenergic stimulation. Although there has been a recent focus on the role of cardiac autophagy in heart failure, its role in heart failure with adrenergic overload has not yet been elucidated. In the present study, we ...
Zhang Youhua Y Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York. Electronic address: - - 2014
Heart failure (HF) is associated with increased atrial fibrillation (AF) risk. Accumulating evidence suggests the presence of myocardial tissue hypothyroidism in HF, which may contribute to HF development. In a recent report we demonstrated that hypothyroidism, like hyperthyroidism, leads to increased AF inducibility. The present study was designed to investigate ...
Obrová Jana J Department of Internal Medicine I - Cardiology,University Hospital Olomouc,Olomouc,Czech - - 2014
An excess of deaths from cardiac causes are reported after many natural disasters. Despite the fact that floods are the most common and most destructive natural disaster worldwide, little is known about their effect on human health. We analyzed the influence of the greatest floods in the Czech Republic on ...
Yao Lan L Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Institute of Cardiopulmonary Cerebral Resuscitation, Sun Yat-sen University, Guangzhou, China Department of Emergency Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, - - 2014
The objective of this study is to examine whether carbon monoxide-releasing molecules (CORMs) can decrease the generation of excessive reactive oxygen species (ROS) in cardiac mitochondria, thereby protecting against postresuscitation myocardial injury and cardiac mitochondrial dysfunction after resuscitation in a rat model of ventricular fibrillation (VF), and further investigated the ...
Corbisiero Raffaele R Deborah Heart and Lung Center, 200 Trenton Rd, Browns Mills, NJ, - - 2014
Congestive heart failure is a major public health epidemic and economic burden in the USA and worldwide. Cardiac resynchronization therapy is an effective therapy for treating congestive heart failure in conjunction with pharmacologic therapy. The average congestive heart failure admission costs approximately US$ 8 billion annually. Current cardiac resynchronization therapy ...
Gong Wei W Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, - - 2014
Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor ...
Wahab Norasyikin A NA Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, - - 2014
Objective: The aim of this case study is to emphasize the importance of α-blockade in managing a rare complication of an untreated pheochromocytoma. Clinical Presentation and Intervention: A 41-year-old man with previous bilateral pheochromocytoma presented with chest pain. He was suffering from cardiac failure and persistent hypotension requiring an inotrope. ...
O'Keefe-McCarthy Sheila S Sheila O'Keefe-McCarthy, PhD, RN Adjunct Scientist, Ross Memorial Hospital, Lindsay, Ontario, Canada. Linda Ready, RN, BNSc, CNCC(C) Clinical Practice Coordinator, City of Kawartha Lakes Family Health Care Team, Lindsay, Ontario, - - 2014
Recognition of specific and nonspecific cardiac-related prodromal symptoms, indicative of myocardial ischemia, is critical for preemptive coronary heart disease (CHD) screening and effective diagnosis and treatment. In this systematic review, we examined whether prodromal symptoms were predictive of acute symptom presentations, cardiac events, or treatment interventions. Studies that measured the ...
Han Chengzong C University of - - 2014
Introduction: Noninvasive cardiac activation imaging of ventricular tachycardia (VT) is important in the clinical diagnosis and treatment of arrhythmias in heart failure (HF) patients. This study investigated the ability of the three-dimensional cardiac electrical imaging (3DCEI) technique for charactering the activation patterns of spontaneously-occurring and norepinephrine (NE) induced VTs in ...
Petriz João Luiz Fernandes JL Instituto do Coração Edson Saad, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Background: Cardiac magnetic resonance imaging provides detailed anatomical information on infarction. However, few studies have investigated the association of these data with mortality after acute myocardial infarction. Objective: To study the association between data regarding infarct size and anatomy, as obtained from cardiac magnetic resonance imaging after acute myocardial infarction, ...
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