Search Results
Results 201 - 250 of 1437
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Angheloiu George O GO Cardiac MRI Center, Gerald McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA, USA, - - 2014
'Septal bounce' is a pathognomonic sign of constrictive pericarditis (CP). The objectives of the study are to resolve the etiology of the septal bounce, to generate septal bounce-related diagnostic tools, and to prove that its presence is related to the mechanical interaction between the atrioventricular inflow and the inter-ventricular septum. ...
Zhao Xiaohan X The Key Laboratory of Experimental Teratology, Ministry of Education and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong 250012, - - 2014
CUL4A and CUL4B are closely related cullin family members and can each assemble a Cullin-RING E3 ligase complex (CRL) and participate in a variety of biological processes. While the CRLs formed by the two cullin members may have common targets, the two appeared to have very different consequences when mutated ...
Rong Xiao-Song XS Department of Cardiothoracic Surgery, Wuxi People's Hospital, Wuxi, - - 2014
: Cardiac c-kit+ cells isolated from cardiac explant-derived cells modestly improve cardiac functions after myocardial infarction; however, their full potential has not yet been realized. The present study was undertaken to determine the isolation and culture of c-kit+ cardiac stem cells (CSCs), and the roles of myocardial injection of CSCs ...
Stub Dion D Baker IDI Heart and Diabetes Research Institute; St Paul's Hospital Vancouver; Department of Intensive Care Alfred Hospital Commercial Road Melbourne, - - 2014
Many patients who suffer cardiac arrest do not respond to standard cardiopulmonary resuscitation. There is growing interest in utilizing veno-arterial extracorporeal membrane oxygenation assisted cardiopulmonary resuscitation (E-CPR) in the management of refractory cardiac arrest. We describe our preliminary experiences in establishing an E-CPR program for refractory cardiac arrest in Melbourne, ...
Gray Clint C Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, New Zealand. Key terms: Developmental programming, miRNA, Cardiovascular disease, Maternal - - 2014
Maternal undernutrition is known to cause cardiac hypertrophy, elevated blood pressure (BP) and endothelial dysfunction in adult offspring. Maternal undernutrition may also lead to disturbances in growth hormone (GH) regulation in offspring. As GH plays a key role in cardiac development, we utilised a model of maternal undernutrition to examine ...
Mahajan Rajiv R Centre for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, - - 2014
Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not only linked to the development of risk factors for atherosclerotic vascular disease but also has a strong association with ventricular hypertrophy, heart failure, atrial fibrillation, and stroke. Recent experimental and clinical studies have demonstrated ...
Hanna Joseph J Gold Coast University Hospital, Australia; University of Queensland, - - 2014
Syncope is a common presentation to emergency departments. Arrhythmias account for 14% of those presentations [1], which requires careful assessment due to the potential for sudden cardiac death (SCD). QTc prolongation either due to congenital channelopathy or acquired aetiology can lead to polymorphic ventricular tachycardia and SCD, and should be ...
Backes Carl H CH Nationwide Children's Hospital, Columbus, - - 2014
Objectives: To characterize the frequency and attributability of death among patients who died within 30 days of their cardiac catheterization (30-day mortality). Background: 30-day post-procedure mortality is commonly used as a quality outcome metric in national cardiac catheterization registries. It is unclear if this parameter is sufficiently specific to meaningfully ...
Win Theingi Tiffany TT Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD; Division of Cardiology, Department of Medicine, University of New - - 2014
Abnormal P-terminal force in V1 (PTFV1) is associated with an increased risk of heart failure, stroke, atrial fibrillation (AF) and death. Our goal was to explore associations of left ventricular (LV) diffuse fibrosis with left atrium (LA) function and ECG measures of LA electrical activity. AF-free patients (n=91, mean age ...
Lambova Sevdalina S Sevdalina Lambova, Department of Propedeutics in Internal Medicine, Medical University, Plovdiv 4002, - - 2014
Primary cardiac involvement, which develops as a direct consequence of systemic sclerosis (SSc), may manifest as myocardial damage, fibrosis of the conduction system, pericardial and, less frequently, as valvular disease. In addition, cardiac complications in SSc may develop as a secondary phenomenon due to pulmonary arterial hypertension and kidney pathology. ...
Juárez-Orozco Luis E LE Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB, Groningen, The - - 2014
Cardiac dysfunction leads to decreased organ perfusion. We aimed to measure cardiac and renal perfusion simultaneously with the use of (13)N-NH3-microPET in different rat models. Ten male Wistar rats underwent sham surgery (n = 5) or permanent coronary artery ligation to induce myocardial infarction (MI, n = 5). Eleven weeks later (13)N-NH3-microPET scan was ...
Davidson Bruce L - - 2014
Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac and venous thromboembolism, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly-acting therapeutic anticoagulants in studies of sufficient patient number and duration. Although there is ...
Fukuhara Shinichi S Division of Cardiac Surgery, Beth Israel Medical Center, New York, NY, USA - - 2014
Left atrial dissection is an exceedingly rare but potentially fatal complication of cardiac surgery. It is most commonly associated with mitral valve surgery, including both replacement and repair, with a reported incidence rate of 0.16%. However, other cardiac surgical or catheter-based interventional procedures are also known as potential predisposing factors. ...
Florian Anca - - 2014
Cardiac involvement is a frequent finding in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies. With this study, we aimed at elucidating the relationship between the phenotypic expression of cardiac involvement and the occurrence of adverse cardiac events in DMD/BMD patients. Eighty-eight male DMD/BMD patients (age 29 ± 14 yrs) were ...
Bosemani Thangamadhan T Section of Pediatric Neuroradiology, Division of Pediatric Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Charlotte R. Bloomberg Children's Center, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD, 21287-0842, - - 2014
Achondroplasia is a skeletal dysplasia with diminished growth of the skull base secondary to defective enchondral bone formation. This leads to narrowing of the foramen magnum and jugular foramina, which further leads to ventricular dilatation and prominence of the emissary veins. The primary goal of our study was to determine ...
Perry Marie-Claude MC Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montréal, QC, H3A 1A3, Canada Departments of - - 2014
The tyrosine kinase receptor ERBB2 is required for normal development of the heart and is a potent oncogene in breast epithelium. Trastuzumab, a monoclonal antibody targeting ERBB2, improves the survival of breast cancer patients but cardiac dysfunction is a major side-effect of the drug. The molecular mechanisms underlying how ERBB2 ...
Genberg M M Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, - - 2014
Hematopoietic cell transplantation (HCT) including preparative regimens with chemotherapy and total body irradiation (TBI) is an accepted treatment for many malignant disorders but may have side-effects for several organs, including the cardiovascular system. The aim of this study was to study very long-term consequences on cardiac function after childhood HCT. ...
Xu Lei L Department of Cardiac Surgery, Shandong Provincial Hospital affiliated to Shandong - - 2014
The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and development of adhesions in conjunction with abdominal surgery. MK2 is ...
Lauriol Jessica J Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United - - 2014
Congenital heart disease is the most common human developmental disorder, affecting ∼1:100 newborns, and is the primary cause of birth-defect related deaths worldwide. As a major regulator of receptor tyrosine kinase (RTK), cytokine and G-protein coupled receptor signaling, the non-receptor protein tyrosine phosphatase SHP2 plays a critical role in normal ...
Kim Ahrong A Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, and BioMedical Research Institute, Pusan National University Hospital, Busan, Republic of - - 2014
The definition and features of the gastroesophageal junction (GEJ) and the histopathologic features of the cardiac mucosa remain controversial. Most reports originate from western countries, which have different prevalence of GEJ adenocarcinoma and gastroesophageal reflux disease (GERD) compared to eastern countries. Therefore, we investigated GEJ anatomic and histopathologic features by ...
Chiu Diana Yuan Yng DY Vascular Research Group, Manchester Academic Health Sciences Centre, Institute of Population Health, The University of Manchester, United Kingdom; Department of Renal Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, United - - 2014
Sudden cardiac death is the most common cause of death in haemodialysis patients, accounting for 25% of all-cause mortality. There are many potential pathological precipitants as most patients with end-stage renal disease have structurally or functionally abnormal hearts. For example, at initiation of dialysis 74% of patients have left ventricular ...
Kron Jordana J Department of Cardiac Electrophysiology, Virginia Commonwealth University, Richmond, - - 2014
Cardiac sarcoidosis can occur in up to 25% of patients with sarcoidosis in other organ systems and may present with conduction abnormalities, ventricular arrhythmias, or heart failure. This review will summarize the state of current knowledge and key questions that remain to be answered. Because cardiac sarcoidosis is a rare, ...
Beukema Rypko J RJ Department of Cardiology, Isala Klinieken, Dr Van Heesweg 2, 8025 AB Zwolle, The - - 2014
Focal atrial tachycardia successfully ablated from the non-coronary cusp (NCC) is rare. Our aim was to describe the characteristics of mapping and ablation therapy of NCC focal atrial tachycardias and to provide a comprehensive review of the literature. Seven patients (age 40 ± 9 years) with symptomatic, drug-refractory atrial tachycardia ...
Rodríguez-Reyna Tatiana S TS Department of Immunology and Rheumatology, Department of Radiology, Department of Cardiology and Emergency Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. - - 2014
Cardiac involvement in SSc is characterized by myocardial fibrosis, arrhythmias and pericarditis. Prevalence studies have shown variable results. The objective of this study was to determine the prevalence of cardiac involvement in SSc patients using the non-invasive, highly sensitive diagnostic methods of cardiac MRI and coronary angiotomography. We included 62 ...
Durante Alessandro A 1Ospedale - - 2014
Sudden cardiac death in the young is a relatively uncommon but marked event usually related to congenital diseases or anomalies. Despite the prevalence of each condition being variable, most common causes include primary myocardial diseases and arrhythmic disorder, frequently with inheritance pattern. Sudden cardiac death is usually preceded by symptoms, ...
Anderson Jeffrey B JB The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: - - 2014
Sudden cardiac death in the young (SCDY) is the leading cause of death in young athletes during sport. Screening young athletes for high-risk cardiac defects is controversial. The purpose of this study was to assess the utility and feasibility of a comprehensive cardiac screening protocol in an adolescent population. Adolescent ...
Yanagisawa Satoshi S Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Cardiology, Chunichi Hospital, Aichi, - - 2014
Patients with greater improvement of cardiac function after cardiac resynchronization therapy (CRT) implantation are identified as "super-responders." However, it remains unclear which kind of preimplant assessments could accurately predict outcomes after CRT. Thus, we aimed to examine the essential predicting factors for super-response to CRT, and to construct an accurate ...
Billette Jacques J Département de - - 2014
The role of the autonomic nervous system in the initiation and maintenance of cardiac arrhythmias was recognized almost a century ago and consequently has been abundantly studied. This article is protected by copyright. All rights reserved.
Jørgensen Peter Godsk - - 2014
Despite 5-7 months of physical inactivity during hibernation, brown bears (Ursus arctos) are able to cope with physiological conditions that would be detrimental to humans. During hibernation, the tissue metabolic demands fall to 25% of the active state. Our objective was to assess cardiac function associated with metabolic depression in ...
Fernandez-Fernandez Alicia A Biomedical Engineering Department, Florida International University, 10555 W. Flagler St., EC 2600, Miami, FL, 33174, - - 2014
Anthracyclines cause severe irreversible cardiac toxicity. The study of changes in cardiac permeability with chemotherapy could enhance the understanding of mechanisms behind cardiac damage, and provide useful information to evaluate anthracycline cardiotoxicity. Thirty-six rats (12 Sprague-Dawley, 12 Wistar, 12 Fischer-344) were randomly assigned to control (n = 21) or doxorubicin (n = 15), and ...
Okamoto Yusuke Y Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, - - 2014
Besides regulating calcium-phosphate metabolism, fibroblast growth factor-23 (FGF23) and Klotho have been proposed to have other roles in heart and vasculature. For example, FGF23 has been associated with cardiac hypertrophy and reduced left ventricular ejection fraction among patients with chronic kidney disease and cardiovascular disorders. The purpose of the study ...
Tokuda Michifumi M Department of Cardiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan, - - 2014
A 40-year-old female presented at our hospital because of heart palpitations. During an electrophysiological study, atrioventricular (AV) conduction showed dual AV nodal physiology. Three types of supraventricular tachycardia (SVT) were induced. The initiation of SVT was reproducibility dependent on a critical A-H interval prolongation. An early premature atrial contraction during ...
Masuda Ryo R Cardiology Division, Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, - - 2014
Although electrical thoracic vein (TV) isolation is an established strategy during atrial fibrillation (AF) ablation, discriminating TV potentials from far-field signals is critical for the achievement. One hundred consecutive drug-refractory symptomatic paroxysmal AF patients who underwent AF catheter ablation were included. All patients underwent circumferential pulmonary vein (PV) isolation during ...
Sharma Jayendra J From the *Divisions of Pediatric Cardiology and †Pediatric Intensive Care, Department of Pediatrics, Lincoln Medical and Mental health center, Bronx, - - 2014
Acute myopericarditis is primarily a pericarditic syndrome with variable myocardial involvement, as evidenced by elevated cardiac enzymes. It is a rare entity, exclusively seen in male adolescents and accounts for less than 2% of the cases of inpatient admissions for chest pain/pericarditis in the pediatric age group. The electrocardiographic changes ...
Baquero Giselle A GA Penn State Hershey Heart & Vascular Institute, Division of Cardiology, Department of Medicine, Penn State College of Medicine, Penn State University, Hershey, - - 2014
AliveCor ECG is an FDA approved ambulatory cardiac rhythm monitor that records a single channel (lead I) ECG rhythm strip using an iPhone. In the past few years, the use of smartphones and tablets with health related applications has significantly proliferated. In this initial feasibility trial, we attempted to reproduce ...
Arnott Clare C Eastern Heart Clinic, Prince of Wales Hospital, Barker Street, Randwick 2023, Australia. Electronic address: - - 2014
A 42 year-old man presented for elective percutaneous lead extraction for pacemaker redundancy. The procedure was performed supine under general anaesthesia via the right femoral vein and was complicated by acute inferior ST elevation and hypotension. Urgent transoesophageal echocardiogram showed inferior left ventricular hypokinesis, right ventricular impairment, a patent foramen ...
Tomita Kengo K Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
Cardiac dysfunction is a frequent and severe complication of septic shock and contributes to the high mortality of sepsis. Although several mechanisms have been suspected to be responsible for sepsis-associated cardiac dysfunction, the precise cause(s) remains unclear to date. We tested the hypothesis that cardiac fibroblasts may play a critical ...
Varma Niraj N Cleveland Clinic, Cleveland, OH, USA. Electronic address: - - 2014
Assess effect of right ventricular pacing (RVP) on left ventricular (LV) activation in heart failure patients with left bundle branch block (LBBB). LV activation during RVP is regarded as similar to LBBB; hence novel CRT algorithms may avoid RVP by adopting "fusion" pacing with intrinsic RBB-mediated conduction. However, other CRT ...
Gonzalez Leopoldo P LP 1Department of Anesthesiology, Botucatu Medical School, UNESP-Univ Estadual Paulista, Botucatu, São Paulo, Brazil. 2Department of Biostatistics, Institute of Biosciences, UNESP-Univ Estadual Paulista, Botucatu, São Paulo, - - 2014
A previous survey performed in our institution demonstrated perioperative pediatric cardiac arrest and mortality rates of 22.9 and 9.8 per 10,000 anesthetics, respectively, and an anesthesia-related cardiac arrest rate of 4.58 per 10,000 anesthetics. Changes in pediatric practices (i.e., safer anesthesia techniques and change in population) may have altered cardiac ...
Zhang Yao-Jun YJ Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, - - 2014
This study aimed to test the hypothesis that berberine, a plant derived antioxidant, attenuates adverse left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction (MI). Moreover, the potential mechanisms that mediated the cardioprotective actions of berberine, in particular the effect on autophagy, were also investigated. ...
Laksman Zachary Z Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, - - 2014
-Left ventricular (LV) and right ventricular (RV) pacing site characteristics have been shown to influence response to cardiac resynchronization therapy (CRT). This study aimed to determine the clinical feasibility of image-guided lead delivery using a 3D navigational model displaying both LV and RV pacing targets. Serial echocardiographic measures of clinical ...
Roque Carla C Arrhythmia Unit & Electrophysiology Laboratories, Ospedale San Raffaele, Milan, - - 2014
-The mechanism of Cardiac Resynchronisation Therapy (CRT)-induced pro-arrhythmia remains unknown. We postulated that pacing from a left ventricular (LV) lead positioned on epicardial scar can facilitate reentrant ventricular tachycardia (VT). The aim of this study was to investigate the relationship between CRT-induced pro-arrhythmia and LV lead location within scar. -Twenty-eight ...
Pang Jianing J Department of Radiology and Biomedical Engineering, Northwestern University, Chicago, Illinois, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
To develop a cardiac and respiratory self-gated four-dimensional (4D) coronary MRA technique for simultaneous cardiac anatomy and function visualization. A contrast-enhanced, ungated spoiled gradient echo sequence with self-gating (SG) and 3DPR trajectory was used for image acquisition. Data were retrospectively binned into different cardiac and respiratory phases based on information ...
Harskamp Ralf E RE Duke Clinical Research Institute, Durham, NC, USA Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands - - 2014
Cardiac ischaemic marker release is associated with adverse clinical outcomes after cardiac surgery. We sought to compare the release of cardiac troponin I (cTnI) after hybrid coronary revascularization (HCR) with off-pump coronary artery bypass surgery (OPCAB). Using data from a prospective single-centre registry, we compared cTnI measured at postoperative day ...
Imazu Miki M National Cerebral and Cardiovascular - - 2014
Although the important role of fibroblast growth factor 23 (FGF23) on cardiac remodeling is suggested in advanced chronic kidney disease (CKD), little is known about the serum FGF23 (sFGF23) levels in patients with heart failure (HF) due to non-ischemic cardiac disease (NICD) and early CKD. The present study aimed to ...
Di Bella Gianluca G aClinical and Experimental Department of Medicine bDepartment of Biomedical Sciences and of Morphologic and Functional Images cDepartment of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Messina dDepartment of Cardiac MRI, Fondazione CNR-Regione Toscana 'G. Monasterio,' Pisa eInstitute of Clinical Physiology, CNR Pisa fEsaote, Florence, - - 2014
Left atrium can be involved by amyloid deposition in familial amyloid polyneuropathy (FAP). The aim of our study is to assess left atrium function in atrial amyloidosis. Twenty-eight FAP patients (53 ± 12 years) and a control group of 22 asymptomatic individuals (49 ± 11 years) underwent strain echocardiography and cardiac magnetic resonance (CMR). ...
Dietrichs Erik Sveberg ES Department of Research and Education, Norwegian Air Ambulance Foundation, 1441 Drøbak, Norway; Anesthesia and Critical Care Research Group, Institute of Clinical Medicine, UiT, The Arctic University of Norway, 9037 Tromsø, Norway. Electronic address: - - 2014
Rewarming from hypothermia is often complicated by cardiac dysfunction, characterized by substantial reduction in stroke volume. Previously we have reported that inotropic agents, working via cardiac β-receptor agonism may exert serious side effects when applied to treat cardiac contractile dysfunction during rewarming. In this study we tested whether Milrinone, a ...
Campos Dijon Henrique Salomé de DH Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, - - 2014
Background: Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. Objective: Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid ...
Zhou Hong-Min HM Cardiovascular Drug Research Center, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Beijing 100850, P.R. - - 2014
Endothelial dysfunction can lead to congestive heart failure and the activation of endothelial ATP-sensitive potassium (KATP) channels may contribute to endothelial protection. Therefore, the present study was carried out to investigate the hypothesis that natakalim, a novel KATP channel opener, ameliorates post-infarction left ventricular remodeling and failure by correcting endothelial ...
Campos Dijon Henrique Salomé de DH Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, - - 2014
Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished. Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and ...
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