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Canpolat Uğur U Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, - - 2014
Vitamin D (VitD) deficiency affects the cardiovascular system via endocrine, paracrine, and autocrine pathways. Limited data are available regarding cardiac autonomic dysfunction in VitD deficiency. The aim of this study was to assess the cardiac autonomic functions by using heart rate recovery index (HRRI) and heart rate variability (HRV) in ...
Kershaw Melissa A MA From the Department of Cardiology at Oakwood Southshore Medical Center in Trenton, Michigan - - 2014
The electrocardiographic (ECG) pattern of high-grade stenosis of the left anterior descending coronary artery (LAD) is important clinically because of the high risk of myocardial infarction and cardiac death if the pattern is not recognized. Although the recognition of this pattern is currently widespread, false-positive ECG changes that mimic this ...
Thooft Aurélie - - 2014
ABSTRACTA young woman presented with cardiac arrest following ingestion of yew tree leaves of the Taxus baccata species. The toxin in yew tree leaves has negative inotropic and dromotropic effects. The patient had a cardiac rhythm that alternated between pulseless electrical activity with a prolonged QRS interval and ventricular fibrillation. ...
Huntjens Peter R PR Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The - - 2014
It is unclear how the position of the left ventricular (LV) lead relative to a scar affects the haemodynamic response in patients with dyssynchronous heart failure receiving cardiac resynchronization therapy. We investigated this complex interaction using a computational model. The CircAdapt computational cardiovascular system model was used to simulate heart ...
Corino Valentina D A VD Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Golgi 39, 20133 Milano, Italy - - 2014
During atrial fibrillation (AF), conventional electrophysiological techniques for assessment of refractory period or conduction velocity of the atrioventricular (AV) node cannot be used. We aimed at evaluating changes in AV nodal properties during administration of metoprolol from electrocardiogram data, and to support our findings with simulated data based on results ...
Holzem Katherine M KM Department of Biomedical Engineering, Washington University, 390E Whitaker Hall, One Brookings Drive, St. Louis, MO 63130-4899, - - 2014
Human cardiac electrophysiology (EP) is a unique system for computational modelling at multiple scales. Due to the complexity of the cardiac excitation sequence, coordinated activity must occur from the single channel to the entire myocardial syncytium. Thus, sophisticated computational algorithms have been developed to investigate cardiac EP at the level ...
Fukushima Keiko K Department of Cardiology, Tokyo Women's Medical University, Tokyo, - - 2014
Atrial fibrillation (AF) is associated with atrial remodeling. We investigate the abilities of preprocedural echocardiographic parameters reflecting atrial remodeling to predict AF recurrence after radiofrequency catheter ablation (RFCA) for paroxysmal AF (PAF). Preprocedural echocardiographic parameters were measured during sinus rhythm in 105 patients with PAF undergoing RFCA. Electrical remodeling was ...
Kazbanov Ivan V IV Department of Physics and Astronomy, Ghent University, Ghent, - - 2014
Acute regional ischemia in the heart can lead to cardiac arrhythmias such as ventricular fibrillation (VF), which in turn compromise cardiac output and result in secondary global cardiac ischemia. The secondary ischemia may influence the underlying arrhythmia mechanism. A recent clinical study documents the effect of global cardiac ischaemia on ...
Liu Nan - - 2014
Fast and accurate risk stratification is essential in the emergency department (ED) as it allows clinicians to identify chest pain patients who are at high risk of cardiac complications and require intensive monitoring and early intervention. In this paper, we present a novel intelligent scoring system using heart rate variability, ...
Akbar Shahid S Research Center, Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, PO Box 6800, Buraidah 51452, Kingdom of Saudi Arabia. Tel. +966 (16) 3802267 Ext. 2330. E-mail. - - 2014
The invention of beta (β)-blockers culminated in a new era in the treatment of cardiovascular diseases (CD), and changed the course of pharmacology research for years to come. Since the introduction of propranolol into clinical practice in 1964, β-blockers enjoyed a special place in the clinicians' armamentarium against CDs, especially ...
Leischik R R University Witten/Herdecke, Faculty of Health, School of Medicine, Hagen, Germany. - - 2014
In the beginning sporting activity may be exhausting, but over time, physical activity turns out to have beneficial effects to the body and even extended cycling or running is an emotional and healthy enrichment in life. On the other hand, spectacular sudden deaths during marathon, football and, just recently, in ...
Lymperopoulos Anastasios A From the Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, 3200 S. University Drive, HPD (Terry) Bldg/Room 1338, Ft. Lauderdale, FL 33328-2018, - - 2014
The ability to stimulate cardiac contractility is known as positive inotropy. Endogenous hormones, such as adrenaline and several natural or synthetic compounds possess this biological property, which is invaluable in the modern cardiovascular therapy setting, especially in acute heart failure or in cardiogenic shock. A number of proteins inside the ...
von Lueder Thomas G TG Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia; Department of Cardiology B, Oslo University Hospital Ullevål, and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, - - 2014
-Angiotensin-receptor neprilysin inhibitors (ARNi), beyond blocking angiotensin II (AngII)-signalling, augment natriuretic peptides by inhibiting their breakdown by neprilysin (NEP). The myocardial effects of ARNi have been little studied until recently. We hypothesized that LCZ696 attenuates left ventricular (LV) remodeling after experimental myocardial infarction (MI), and that this may be contributed ...
Chen Wen-Pin WP Institute of Pharmacology, College of Medicine, National Taiwan University, - - 2014
Our previous study found that A83-01, a small molecule type 1 TGFβ receptor inhibitor, could induce proliferation of postnatal Nkx2.5+ cardiomyoblasts in vitro and enhance their cardiomyogenic differentiation. The present study addresses whether A83-01 treatment in vivo could increase cardiomyogenesis and improve cardiac function after myocardial infarction (MI) through an ...
Xu Jiefeng J 1Weil Institute of Critical Care Medicine, Rancho Mirage, CA. 2Department of Emergency Medicine, Yuyao People's Hospital, Medical School of Ningbo University, Ningbo, China. 3Keck School of Medicine of the University of Southern California, Los Angeles, CA. 4Department of Emergency Medicine, School of Medicine of the University of California, San Diego, - - 2014
Cardiac arrest and resuscitation are models of whole body ischemia reperfusion injury. Postresuscitation myocardial and cerebral dysfunction are major causes of high mortality and morbidity. Remote ischemic postconditioning has been proven to provide potent protection of the heart and brain against ischemia reperfusion injury. In this study, we investigated the ...
Sara Jaskanwal D JD Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
Sudden cardiac death accounts for approximately 50% of all deaths attributed to cardiovascular disease in the United States. It is most commonly associated with coronary artery disease and can be its initial manifestation or may occur in the period after an acute myocardial infarction. Decreasing the rate of sudden cardiac ...
Wang J J Emergency and Intensive Care Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, - - 2014
Atrial fibrillation (AF) is one of the most common arrhythmia complications of acute coronary syndrome (ACS). The incidence of new-onset AF is 2.3-37 %, and it is an important predictor of a patient's morbidity, mortality, and prolonged hospitalization. Various risk factors for the development of new-onset AF after ACS have been ...
Salem Reda - - 2014
IntroductionThe occurrence of cardiac dysfunction is common after subarachnoid haemorrhage (SAH) and was hypothesized to be related to the release of endogenous catecholamines. The aim of this prospective study was to evaluate the relationship between endogenous catecholamine and cardiac dysfunction at the onset and during the first week after SAH.MethodsForty ...
Alhous M Hafez A MH Department of Cardiology, Aberdeen Royal Infirmary/University of Aberdeen, Aberdeen AB25 2ZN, UK - - 2014
To compare the effects on left ventricular (LV) function of right ventricular (RV) septal pacing vs. cardiac resynchronization therapy (CRT) in patients with an indication for the latter. Cardiac resynchronization therapy is an effective therapy in patients with drug-refractory heart failure. Despite advances in implantation techniques, LV lead placement can ...
März Imke I Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, - - 2014
Norwegian Forest cats (NFCs) are often listed as a breed predisposed to cardiomyopathy, but the characteristics of cardiomyopathy in this breed have not been described. The aim of this preliminary study was to report the features of NFC cardiomyopathy based on prospective echocardiographic screening of affected family groups; necropsy findings; ...
Long Michael A MA Department of Cardiothoracic Surgery, Free State University, Bloemfontein, South Africa. Electronic address: - - 2014
An adult with a grossly dilated right atrium of unknown etiology is presented. The right atrial volume was estimated at more than 1,900 mL, with normal sized left atrium and ventricles. She presented in atrial fibrillation and right ventricular failure. She underwent subsequent reduction atrioplasty of the right atrium and ...
Lei Qian Q Department of Cardiac Surgery and Anesthesiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, and Guangdong Academy of Medical Sciences, Guangzhou, - - 2014
Giant left atrial diverticulum is a rare congenital abnormality that is most commonly diagnosed in childhood. Here, we report the case of an 18-year-old woman who presented with chest tightness. Contrast-enhanced computed tomography imaging revealed a 12-cm × 7-cm left atrial diverticulum. After transesophageal echocardiography was used to exclude left atrial thrombus ...
Duchateau Nicolas N Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: - - 2014
Time-to-peak measurements and single-parameter observations are cumbersome and often confusing for quantifying local changes in myocardial function. Recent spatiotemporal normalization techniques can provide a global picture of myocardial motion and strain patterns and overcome some of these limitations. Despite these advances, the quantification of pattern changes remains descriptive, which limits ...
Sassone Biagio B Department of Cardiology, SS. ma Annunziata Hospital, Azienda Unità Sanitaria Locale Ferrara, Ferrara, Italy. Electronic address: - - 2014
Left bundle branch block (LBBB) is the most reliable electrocardiographic predictor of responsiveness to cardiac resynchronization therapy (CRT). However, not all patients with LBBB will respond to CRT. Our aim was to investigate the interaction between QRS duration, LBBB-type morphology, and the responsiveness to CRT. We retrospectively analyzed electrocardiograms of ...
Kakroo Mashhood Ajaz MA Division of Cardiovascular Medicine, University of Toledo, Toledo, Ohio, - - 2014
Reverse Takotsubo cardiomyopathy (TCM) is a recently described variant of classic TCM. In contrast to classic TCM, the regional wall motion abnormalities are localized in the basal segments. The condition can be triggered by acute stressful events, including acute medical illnesses. The wall motion abnormalities and left ventricular dysfunction are ...
Hörburger David D Vienna General Hospital, Department of Emergency Medicine, Medical University of Vienna, Währinger Gürtel 18-20/6D, 1090 Vienna, - - 2014
Evaluation of the treatment, epidemiology and outcome of cardiac arrest in the television franchise Star Trek. Retrospective cohort study of prospective events. Screening of all episodes of Star Trek: The Next Generation, Star Trek: Deep Space Nine and Star Trek: Voyager for cardiac arrest events. Documentation was performed according to ...
Nagao Michinobu M Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka City, Fukuoka, 812-8582, Japan, - - 2014
Iron deficiency and cardiac sympathetic impairment play a role in the worsening of heart failure, and these two conditions may be linked. The present study aimed to clarify the relationship between myocardial iron deficiency, cardiac sympathetic activity, and major adverse cardiac events (MACE) in patients with dilated cardiomyopathy (DCM). Cardiac ...
Jayawardena Tilanthi M TM Medicine, Duke University Medical - - 2014
Rationale: A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of micro-RNAs (miR combo) into the infarcted myocardium leads to ...
Baczkó István I Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged Dóm tér 12., 6720 Szeged, Hungary. - - 2014
Heart failure (HF) is a clinical syndrome characterized by significant impairment of cardiac ventricular function. Atrial fibrillation (AF) is the most commonly observed sustained arrhythmia in clinical practice. Both HF and AF are associated with increased morbidity and mortality and their prevalence increases with age. Approximately 50% of patients with ...
Kermorgant Marc M Université Européenne de Bretagne, France; Université de Brest, France; INSERM UMR 1101, Laboratoire de Traitement de l'Information Médicale, Laboratoire de Neurophysiologie, SFR 148 ScInBioS, Faculté de Médecine des Sciences de la Santé, 22 Avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France; CHU de Brest, - - 2014
QT interval of the electrocardiogram (ECG) is a measure of the duration of the ventricular depolarization and repolarization. In humans, prolongation of the QT interval is a known clinical risk factor for the development of ventricular arrhythmias including 'Torsades de Pointes' and possible sudden cardiac death. After oral administration, fluoxetine ...
Miglioranza Marcelo Haertel MH Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy; Cardiology Institute of Rio Grande do Sul, Porto Alegre, - - 2014
Tricuspid annular (TA) size and function play important roles in planning the need for associated TA annuloplasty in patients undergoing cardiac surgery for left-sided heart valve diseases. However, TA diameter normative values and the extent of TA dynamic changes during cardiac cycle remain to be established. This was a prospective, ...
Wang Xule X Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan City 430060, People's Republic of China Cardiovascular Research Institute of Wuhan University, Wuhan City 430060, People's Republic of - - 2014
The aim of the present study was to explore the effect of renal sympathetic denervation (RSD) on the progression of paroxysmal atrial fibrillation (AF) in canines with long-term intermittent atrial pacing. Nineteen beagles were randomly divided into sham-operated group (six dogs), control group (six dogs), and RSD group (seven dogs). ...
Wildi Karin K Department of Cardiology, University Hospital Basel, Switzerland Department of Intensive Care, University Hospital Basel, - - 2014
In contrast to ST-elevation myocardial infarction (STEMI), in non-STEMI (NSTEMI) patients the need for continuous rhythm monitoring in a coronary care unit, respective incidence and timing of serious arrhythmias are poorly defined. We used a derivation-validation design and data from two independent prospective cohorts of consecutive haemodynamically stable NSTEMI patients ...
Kirubakaran Senthil S Manchester Heart Centre, Manchester Royal Infirmary, Manchester, United Kingdom. Electronic address: - - 2014
Electrogram fractionation and atrial fibrosis are both thought to be pathophysiological hallmarks of evolving persistence of atrial fibrillation (AF), but recent studies in humans have shown that they do not colocalize. The interrelationship and relative roles of fractionation and fibrotic change in AF persistence therefore remain unclear. The aim of ...
Garcia Santiago S Santiago Garcia, Minneapolis VA Healthcare System, University of Minnesota, MN 55417, United - - 2014
Cardiovascular disease is the leading cause of death in patients with peripheral arterial disease (PAD). Coronary artery disease (CAD) is highly prevalent, and often times coexist, in patients with PAD. The management of patients with PAD that requires a high-risk vascular surgical procedure for intermittent claudication, critical limb ischemia or ...
Hofmann Nina Patricia NP Nina Patricia Hofmann, Hugo A Katus, Grigorios Korosoglou, Department of Cardiology, University of Heidelberg, 69120 Heidelberg, - - 2014
Quantitative assessment of myocardial perfusion by myocardial blush grade (MBG) is an angiographic computer-assisted method to assess myocardial tissue-level reperfusion in patients with acute coronary syndromes and microvascular integrity in heart transplant recipients with suspected cardiac allograft vasculopathy. This review describes the ability of quantitative MBG as a simple, fast ...
Uribarri Aitor A Cardiology Department, Hospital General Universitario 'Gregorio Marañón', Madrid, Spain - - 2014
Little is known about the role of time to initiation of therapeutic hypothermia and time to target temperature (TTT) in the prognosis of patients resuscitated from cardiac arrest. A retrospective analysis was performed in 145 survivors of cardiac arrest who underwent therapeutic hypothermia between January 2003 and January 2013. The ...
van Deursen Caroline J M CJ Cardiovascular Research Institute Maastricht, Department of Physiology, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht, Department of Cardiology, Maastricht, the - - 2014
QRS duration and left bundle branch block (LBBB) morphology are used to select patients for cardiac resynchronization therapy (CRT). We investigated whether the area of the QRS complex (QRSAREA) on the 3-dimensional vectorcardiogram (VCG) can improve patient selection. VCG (Frank orthogonal lead system) was recorded prior to CRT device implantation ...
Zhabyeyev Pavel P Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, - - 2014
Phosphatidylinositide 3-kinase (PI3K) signaling plays a critical role in maintaining normal cardiac structure and function. PI3Kα and PI3Kγ are the dominant cardiac isoforms and have both adaptive and maladaptive roles in heart disease. Broad spectrum PI3K inhibitors are emerging as potential new chemotherapeutic agents which may have deleterious long-term effects ...
Abd El Rahman Mohamed M 1Department of Pediatric Cardiology,Saarland University - - 2014
Background: We aimed to assess biatrial size and function, interactions on atrial and ventricular levels, and atrio-ventricular coupling in patients after tetralogy of Fallot repair. Methods: A total of 34 patients with a mean age of 20.9±9 years, and 35 healthy controls, underwent two-dimensional speckle tracking echocardiography for ventricular and ...
Matsuhisa Hironori H Department of Cardiovascular Surgery, Kobe Children's - - 2014
Background:The importance of ventricular pacing site in pediatric pacemaker therapy has gradually become recognized. We reviewed our experience with a left ventricular (LV)-prioritized pacing strategy.Methods and Results:Between 2000 and 2012, 60 patients underwent 76 permanent pacemaker implantations. Eight of the 29 reoperations involved ventricular lead repositioning for pacing-induced ventricular dysfunction. Freedom from ...
Stembridge Mike M Cardiff School of Sport, Cardiff Metropolitan University, Cardiff, UK - - 2014
Both short-term and life-long high altitude (HA) exposure challenge the cardiovascular system to meet the metabolic demand for oxygen (O2) in a hypoxic environment. As the demand for O2 delivery increases during exercise, the circulatory component of oxygen transport is placed under additional stress. Acute adaptation and chronic remodelling of ...
Jouffroy R R Intensive Care Unit, Anaesthesiology department and SAMU of Paris, Hôpital Necker, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Paris, France. Electronic address: - - 2014
To examine whether values of arterial base excess or lactate taken 3hours after starting ECLS indicate poor prognosis and if this can be used as a screening tool to follow Extra Corporeal Life Support after Out Hospital Cardiac Arrest due to acute coronary syndrome. Single Centre retrospective observational study. University ...
Damiano Bruce P BP Global Safety Pharmacology, Preclinical Development & Safety, Discovery Sciences, Janssen Research and Development, LLC 1400 McKean Rd, Spring House, PA, USA. Electronic address: - - 2014
Preclinical proarrhythmic risk assessment of drug candidates is focused predominantly on arrhythmias arising from repolarization abnormalities. However, drug-induced cardiac conduction slowing is associated with significant risk of life-threatening ventricular arrhythmias, particularly in a setting of cardiac ischemia. Therefore, we optimized and characterized an anesthetized dog model to evaluate the potential ...
Berenfeld Omer O Center for Arrhythmia Research, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address: - - 2014
Atrial fibrillation (AF) is the most common cardiac arrhythmia; however, therapy is suboptimal. We review recent data on dynamics of wave propagation during AF and its mechanistic link to the substrate. Data show that the dominant frequency (DF) increase during transition to persistent AF may be explained by rotor acceleration. ...
Liu Chen C Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080, - - 2014
Cardiac hypertrophy is a major risk factor of cardiovascular morbidity and mortality. Autophagy is established to be involved in regulating cardiac hypertrophy. REDD1, a stress-responsive protein, is proved to contribute in autophagy induction. However, the role of REDD1 in cardiac hypertrophy remains unknown. Our study demonstrated that REDD1 knockdown by ...
Gupta Punkaj P Division of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address: - - 2014
Multicenter data regarding cardiac arrest in children undergoing heart operations are limited. We describe epidemiology and outcomes associated with postoperative cardiac arrest in a large multiinstitutional cohort. Patients younger than 18 years in the Society of Thoracic Surgeons Congenital Heart Surgery Database (2007 through 2012) were included. Patient factors, operative ...
Muto Carmine C Cardiology Department, Ospedale S. Maria della Pietà, Nola, Italy. Electronic address: - - 2014
The main objective of research in pacemaker therapy has been to provide the best physiologic way to pace the heart. Despite the good results provided by right ventricular pacing minimization and by biventricular pacing in specific subsets of heart failure patients, these options present many limitations for standard pacemaker recipients. ...
Pellicori Pierpaolo P Department of Cardiology, Castle Hill Hospital, Hull York Medical School (at University of Hull), Kingston Upon Hull HU16 5JQ, UK pierpaolo.pellicori@hey.nhs.uk - - 2014
Left atrial (LA) volume is an important marker of cardiac dysfunction and cardiovascular outcome in heart failure (HF), but LA function is rarely measured. Left atrial emptying function (LAEF), its clinical associations and prognostic value was studied in outpatients referred with suspected HF who were in sinus rhythm and had ...
Hummel Yoran M YM Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen , The - - 2014
Background. Cardiac morbidity is an important late effect in long-term childhood cancer survivors (CCS) treated with cardiotoxic agents or radiotherapy (RT) on the chest. However, there is limited data on the long-term cardiac sequelae in CCS who only received cranial RT. We hypothesized that cranial RT might negatively influence cardiac ...
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