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Bauer Ralf R Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg , Heidelberg , Germany - - 2014
Abstract Background: Transthyretin-related amyloidosis (ATTR) is characterized by a wide heterogeneity of genotypes and predominantly neurological and cardiac phenotypes. This study aims to characterize a cohort of patients with the rare transthyretin (TTR) Val20Ile (p.TTRVal40Ile) variant. Methods and results: This study comprises a single-center cohort of 59 individuals subsequently evaluated ...
Moss Arthur J AJ University of Rochester Medical Center, Rochester, NY - - 2014
A lot has transpired in our understanding of the inherited Long QT syndrome (LQTS) since the first description of a family with prolonged QT interval, deafness, and sudden death by Jervell and Lange-Nielsen in 1957(1) and a similar family reported in 1958 by Levine, et al.(2) Several children with LQTS ...
Hofmann N P NP Department of Cardiology, University of Heidelberg, Heidelberg, - - 2014
We sought to determine the ability of quantitative myocardial perfusion reserve index (MPRI) by cardiac magnetic resonance (CMR) and high-sensitive troponin T (hsTnT) for the prediction of cardiac allograft vasculopathy (CAV) and cardiac outcomes in heart transplant (HT) recipients. In 108 consecutive HT recipients (organ age 4.1 ± 4.7 years, 25 [23%] with ...
Flam Benjamin B Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna, Stockholm, Sweden - - 2014
Pheochromocytoma classically displays a variety of rather benign symptoms, such as headache, palpitations, and sweating, although severe cardiac manifestations have been described. We report a case of pheochromocytoma-induced inverted takotsubo-like cardiomyopathy leading to shock and cardiac arrest successfully treated with extracorporeal membrane oxygenation (ECMO) as a bridge to pharmacological therapy ...
Eschalier Romain R Hôpital Cardiologique du Haut-Lévêque, CHU Bordeaux, Université Bordeaux, IHU LIRYC, Bordeaux, France; Clermont Université, Université d'Auvergne, Cardio Vascular Interventional Therapy and Imaging (CaVITI), Image Science for Interventional Techniques (ISIT), UMR6284, and CHU Clermont-Ferrand, Cardiology Department, F-63003 Clermont-Ferrand, - - 2014
Left Bundle Branch Block (LBBB) leads to prolonged left ventricular (LV) total activation time (TAT) and ventricular electrical uncoupling (VEU: mean LV activation time minus mean right ventricular (RV) activation time); both have been shown to be preferential targets for cardiac resynchronization therapy (CRT). Whether RV apical pacing (RVAP) produces ...
Ban Ji-Eun JE Division of Cardiology,Department of Internal Medicine,Korea University Medical Center,Seoul,Republic of - - 2014
A 31-year-old patient previously underwent a Mustard operation presented with palpitations. Atrial tachycardia and paroxysmal atrial fibrillation were documented on the surface electrocardiogram. Under the guidance of a three-dimensional electroanatomic mapping system, ablation of the isolated left-sided pulmonary vein and a cavo-tricuspid isthmus-dependent intra-atrial macro re-entry circuit eliminated atrial tachycardia ...
Hesselkilde Eva Z - - 2014
BackgroundDespite increased focus on cardiac arrhythmias in horses, the nature and prevalence is still poorly described. Case reports suggest that arrhythmias occurring secondary to systemic disease are seen more commonly in the clinic than arrhythmias caused by cardiac disease. The aim of this study was to investigate the prevalence of ...
Blustin Jodi M JM 1 Division of Cardiovascular Diseases, Gonda Vascular Center, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, - - 2014
The most feared consequence of atrial fibrillation (AF) is thromboembolism, either to the brain causing stroke or to the non-cerebral circulation. Valvular atrial fibrillation (VAF) and non-valvular atrial fibrillation (NVAF) differ not only by morphological substrate of arrhythmia but also by the rate of thromboembolic complications, predisposing factors and destination ...
Koenig Matthew A MA The Queen's Medical Center, Neuroscience Institute, 1301 Punchbowl Street, QET5, Honolulu, HI 96813, USA. Electronic address: - - 2014
Brain injury represents the major cause of long-term disability and mortality among patients resuscitated from cardiac arrest. Brain-directed therapies include maintenance of normal oxygenation, hemodynamic support to optimize cerebral perfusion, glycemic control, and targeted temperature management. Pertinent guidelines and recommendations are reviewed for brain-directed treatment. The latest clinical trial data ...
Matrone Gianfranco G 1 British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh , Edinburgh, United Kingdom - - 2014
Abstract Mammalian models of cardiac disease have provided unique and important insights into human disease but have become increasingly challenging to produce. The zebrafish could provide inexpensive high-throughput models of cardiac injury and repair. We used a highly targeted laser, synchronized to fire at specific phases of the cardiac cycle, ...
Travers S S Fire Brigade of Paris, Emergency medical department. Electronic address: - - 2014
Dispatcher-assisted cardiopulmonary resuscitation increases the likelihood of survival and thus is highly recommended. But the detection rate of out-of-hospital cardiac arrest (OHCA) is very different from one system to another, and early recognition of cardiac arrest in the dispatch centre remains challenging. The aim of this study was to assess ...
Liou Kevin K Department of Cardiology, Eastern Heart Clinic, Prince of Wales Hospital, Randwick, Sydney, - - 2014
Left atrial fibromuscular band is a rare congenital cardiac anomaly. We present a patient with an incidental finding of left atrial band on an intra-operative transesophageal echocardiogram and characterize its appearance on two-dimensional and three-dimensional echocardiograms.
Liu Cheng-Fang CF *Department of Physiology, Shanxi Medical University, Taiyuan, China; †Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA; and ‡Department of Physiology, School of Basic Medicine Peking Union Medical College, Beijing, - - 2014
: Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this question. Cardiac ...
Okamoto Emi E EE New York University School of Medicine, New York, New York, United States of - - 2014
Twenty to thirty percent of persons with Trypanosoma cruzi infection eventually develop cardiomyopathy. If an early indicator were to be identified and validated in longitudinal studies, this could enable treatment to be prioritized for those at highest risk. We evaluated cardiac and extracellular matrix remodeling markers across cardiac stages in ...
Yildiz Okan O Department of Pediatric Cardiovascular Surgery, Istanbul Mehmet Akif Ersoy Thoracic & Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey - - 2014
Myocardial bridging (MB) is a rare coronary anomaly in children which is typically associated with hypertrophic obstructive cardiomyopathy (HCM) or left ventricular hypertrophy. Hypertrophic obstructive cardiomyopathy is the leading cause of sudden cardiac death in young patients, and the association of myocardial ischemia with sudden death has been recognized in ...
Nguyen B L BL Electrophysiology Section, Department of Cardiology, Polo Pontino ICOT Latina, Sapienza University of Rome, Italy. - - 2014
ST-segment elevation in the right precordial electrocardiography (ECG) leads in Brugada syndrome (BS) can be unmasked by class I anti-arrhythmic drugs (sodium channel blockers) administration. It is still debated whether this ECG pattern is better explained by abnormal repolarization or ventricular conduction and depolarization. Conduction diseases can conceal type 1 ...
Abu-Zeitone Abeer A Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York. Electronic address: - - 2014
In LQTS, β-blocker therapy is effective in reducing the risk of cardiac events (syncope, aborted cardiac arrest, sudden cardiac death). Limited studies have compared the efficacy of different β-blockers. The goal of this study was to compare the efficacy of different β-blockers in long QT syndrome (LQTS) and in genotype-positive patients ...
van Dijk Gaby Pons - - 2014
The exact prevalence and nature of cardiac involvement in facioscapulohumeral muscular dystrophy (FSHD) is unknown. Nevertheless, the current opinion is that symptomatic cardiac disease is rare. We performed a cardiac screening [electrocardiogram (ECG) and echocardiography in the event of ECG abnormalities] in 75 genetically confirmed, ambulant FSHD patients without cardiac ...
Angheloiu George O GO Cardiac MRI Center, Gerald McGinnis Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA, USA, - - 2014
'Septal bounce' is a pathognomonic sign of constrictive pericarditis (CP). The objectives of the study are to resolve the etiology of the septal bounce, to generate septal bounce-related diagnostic tools, and to prove that its presence is related to the mechanical interaction between the atrioventricular inflow and the inter-ventricular septum. ...
Zhao Xiaohan X The Key Laboratory of Experimental Teratology, Ministry of Education and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong 250012, - - 2014
CUL4A and CUL4B are closely related cullin family members and can each assemble a Cullin-RING E3 ligase complex (CRL) and participate in a variety of biological processes. While the CRLs formed by the two cullin members may have common targets, the two appeared to have very different consequences when mutated ...
Rong Xiao-Song XS Department of Cardiothoracic Surgery, Wuxi People's Hospital, Wuxi, - - 2014
: Cardiac c-kit+ cells isolated from cardiac explant-derived cells modestly improve cardiac functions after myocardial infarction; however, their full potential has not yet been realized. The present study was undertaken to determine the isolation and culture of c-kit+ cardiac stem cells (CSCs), and the roles of myocardial injection of CSCs ...
Stub Dion D Baker IDI Heart and Diabetes Research Institute; St Paul's Hospital Vancouver; Department of Intensive Care Alfred Hospital Commercial Road Melbourne, - - 2014
Many patients who suffer cardiac arrest do not respond to standard cardiopulmonary resuscitation. There is growing interest in utilizing veno-arterial extracorporeal membrane oxygenation assisted cardiopulmonary resuscitation (E-CPR) in the management of refractory cardiac arrest. We describe our preliminary experiences in establishing an E-CPR program for refractory cardiac arrest in Melbourne, ...
Gray Clint C Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, New Zealand. Key terms: Developmental programming, miRNA, Cardiovascular disease, Maternal - - 2014
Maternal undernutrition is known to cause cardiac hypertrophy, elevated blood pressure (BP) and endothelial dysfunction in adult offspring. Maternal undernutrition may also lead to disturbances in growth hormone (GH) regulation in offspring. As GH plays a key role in cardiac development, we utilised a model of maternal undernutrition to examine ...
Backes Carl H CH Nationwide Children's Hospital, Columbus, - - 2014
Objectives: To characterize the frequency and attributability of death among patients who died within 30 days of their cardiac catheterization (30-day mortality). Background: 30-day post-procedure mortality is commonly used as a quality outcome metric in national cardiac catheterization registries. It is unclear if this parameter is sufficiently specific to meaningfully ...
Win Theingi Tiffany TT Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD; Division of Cardiology, Department of Medicine, University of New - - 2014
Abnormal P-terminal force in V1 (PTFV1) is associated with an increased risk of heart failure, stroke, atrial fibrillation (AF) and death. Our goal was to explore associations of left ventricular (LV) diffuse fibrosis with left atrium (LA) function and ECG measures of LA electrical activity. AF-free patients (n=91, mean age ...
Lambova Sevdalina S Sevdalina Lambova, Department of Propedeutics in Internal Medicine, Medical University, Plovdiv 4002, - - 2014
Primary cardiac involvement, which develops as a direct consequence of systemic sclerosis (SSc), may manifest as myocardial damage, fibrosis of the conduction system, pericardial and, less frequently, as valvular disease. In addition, cardiac complications in SSc may develop as a secondary phenomenon due to pulmonary arterial hypertension and kidney pathology. ...
Juárez-Orozco Luis E LE Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB, Groningen, The - - 2014
Cardiac dysfunction leads to decreased organ perfusion. We aimed to measure cardiac and renal perfusion simultaneously with the use of (13)N-NH3-microPET in different rat models. Ten male Wistar rats underwent sham surgery (n = 5) or permanent coronary artery ligation to induce myocardial infarction (MI, n = 5). Eleven weeks later (13)N-NH3-microPET scan was ...
Davidson Bruce L - - 2014
Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac and venous thromboembolism, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly-acting therapeutic anticoagulants in studies of sufficient patient number and duration. Although there is ...
Fukuhara Shinichi S Division of Cardiac Surgery, Beth Israel Medical Center, New York, NY, USA - - 2014
Left atrial dissection is an exceedingly rare but potentially fatal complication of cardiac surgery. It is most commonly associated with mitral valve surgery, including both replacement and repair, with a reported incidence rate of 0.16%. However, other cardiac surgical or catheter-based interventional procedures are also known as potential predisposing factors. ...
Florian Anca - - 2014
Cardiac involvement is a frequent finding in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies. With this study, we aimed at elucidating the relationship between the phenotypic expression of cardiac involvement and the occurrence of adverse cardiac events in DMD/BMD patients. Eighty-eight male DMD/BMD patients (age 29 ± 14 yrs) were ...
Bosemani Thangamadhan T Section of Pediatric Neuroradiology, Division of Pediatric Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Charlotte R. Bloomberg Children's Center, Sheikh Zayed Tower, Room 4174, 1800 Orleans Street, Baltimore, MD, 21287-0842, - - 2014
Achondroplasia is a skeletal dysplasia with diminished growth of the skull base secondary to defective enchondral bone formation. This leads to narrowing of the foramen magnum and jugular foramina, which further leads to ventricular dilatation and prominence of the emissary veins. The primary goal of our study was to determine ...
Perry Marie-Claude MC Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montréal, QC, H3A 1A3, Canada Departments of - - 2014
The tyrosine kinase receptor ERBB2 is required for normal development of the heart and is a potent oncogene in breast epithelium. Trastuzumab, a monoclonal antibody targeting ERBB2, improves the survival of breast cancer patients but cardiac dysfunction is a major side-effect of the drug. The molecular mechanisms underlying how ERBB2 ...
Genberg M M Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, - - 2014
Hematopoietic cell transplantation (HCT) including preparative regimens with chemotherapy and total body irradiation (TBI) is an accepted treatment for many malignant disorders but may have side-effects for several organs, including the cardiovascular system. The aim of this study was to study very long-term consequences on cardiac function after childhood HCT. ...
Xu Lei L Department of Cardiac Surgery, Shandong Provincial Hospital affiliated to Shandong - - 2014
The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and development of adhesions in conjunction with abdominal surgery. MK2 is ...
Lauriol Jessica J Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United - - 2014
Congenital heart disease is the most common human developmental disorder, affecting ∼1:100 newborns, and is the primary cause of birth-defect related deaths worldwide. As a major regulator of receptor tyrosine kinase (RTK), cytokine and G-protein coupled receptor signaling, the non-receptor protein tyrosine phosphatase SHP2 plays a critical role in normal ...
Kim Ahrong A Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, and BioMedical Research Institute, Pusan National University Hospital, Busan, Republic of - - 2014
The definition and features of the gastroesophageal junction (GEJ) and the histopathologic features of the cardiac mucosa remain controversial. Most reports originate from western countries, which have different prevalence of GEJ adenocarcinoma and gastroesophageal reflux disease (GERD) compared to eastern countries. Therefore, we investigated GEJ anatomic and histopathologic features by ...
Chiu Diana Yuan Yng DY Vascular Research Group, Manchester Academic Health Sciences Centre, Institute of Population Health, The University of Manchester, United Kingdom; Department of Renal Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, United - - 2014
Sudden cardiac death is the most common cause of death in haemodialysis patients, accounting for 25% of all-cause mortality. There are many potential pathological precipitants as most patients with end-stage renal disease have structurally or functionally abnormal hearts. For example, at initiation of dialysis 74% of patients have left ventricular ...
Kron Jordana J Department of Cardiac Electrophysiology, Virginia Commonwealth University, Richmond, - - 2014
Cardiac sarcoidosis can occur in up to 25% of patients with sarcoidosis in other organ systems and may present with conduction abnormalities, ventricular arrhythmias, or heart failure. This review will summarize the state of current knowledge and key questions that remain to be answered. Because cardiac sarcoidosis is a rare, ...
Beukema Rypko J RJ Department of Cardiology, Isala Klinieken, Dr Van Heesweg 2, 8025 AB Zwolle, The - - 2014
Focal atrial tachycardia successfully ablated from the non-coronary cusp (NCC) is rare. Our aim was to describe the characteristics of mapping and ablation therapy of NCC focal atrial tachycardias and to provide a comprehensive review of the literature. Seven patients (age 40 ± 9 years) with symptomatic, drug-refractory atrial tachycardia ...
Rodríguez-Reyna Tatiana S TS Department of Immunology and Rheumatology, Department of Radiology, Department of Cardiology and Emergency Department, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. - - 2014
Cardiac involvement in SSc is characterized by myocardial fibrosis, arrhythmias and pericarditis. Prevalence studies have shown variable results. The objective of this study was to determine the prevalence of cardiac involvement in SSc patients using the non-invasive, highly sensitive diagnostic methods of cardiac MRI and coronary angiotomography. We included 62 ...
Durante Alessandro A 1Ospedale - - 2014
Sudden cardiac death in the young is a relatively uncommon but marked event usually related to congenital diseases or anomalies. Despite the prevalence of each condition being variable, most common causes include primary myocardial diseases and arrhythmic disorder, frequently with inheritance pattern. Sudden cardiac death is usually preceded by symptoms, ...
Anderson Jeffrey B JB The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: - - 2014
Sudden cardiac death in the young (SCDY) is the leading cause of death in young athletes during sport. Screening young athletes for high-risk cardiac defects is controversial. The purpose of this study was to assess the utility and feasibility of a comprehensive cardiac screening protocol in an adolescent population. Adolescent ...
Yanagisawa Satoshi S Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Cardiology, Chunichi Hospital, Aichi, - - 2014
Patients with greater improvement of cardiac function after cardiac resynchronization therapy (CRT) implantation are identified as "super-responders." However, it remains unclear which kind of preimplant assessments could accurately predict outcomes after CRT. Thus, we aimed to examine the essential predicting factors for super-response to CRT, and to construct an accurate ...
Billette Jacques J Département de - - 2014
The role of the autonomic nervous system in the initiation and maintenance of cardiac arrhythmias was recognized almost a century ago and consequently has been abundantly studied. This article is protected by copyright. All rights reserved.
Jørgensen Peter Godsk - - 2014
Despite 5-7 months of physical inactivity during hibernation, brown bears (Ursus arctos) are able to cope with physiological conditions that would be detrimental to humans. During hibernation, the tissue metabolic demands fall to 25% of the active state. Our objective was to assess cardiac function associated with metabolic depression in ...
Fernandez-Fernandez Alicia A Biomedical Engineering Department, Florida International University, 10555 W. Flagler St., EC 2600, Miami, FL, 33174, - - 2014
Anthracyclines cause severe irreversible cardiac toxicity. The study of changes in cardiac permeability with chemotherapy could enhance the understanding of mechanisms behind cardiac damage, and provide useful information to evaluate anthracycline cardiotoxicity. Thirty-six rats (12 Sprague-Dawley, 12 Wistar, 12 Fischer-344) were randomly assigned to control (n = 21) or doxorubicin (n = 15), and ...
Okamoto Yusuke Y Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, - - 2014
Besides regulating calcium-phosphate metabolism, fibroblast growth factor-23 (FGF23) and Klotho have been proposed to have other roles in heart and vasculature. For example, FGF23 has been associated with cardiac hypertrophy and reduced left ventricular ejection fraction among patients with chronic kidney disease and cardiovascular disorders. The purpose of the study ...
Tokuda Michifumi M Department of Cardiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan, - - 2014
A 40-year-old female presented at our hospital because of heart palpitations. During an electrophysiological study, atrioventricular (AV) conduction showed dual AV nodal physiology. Three types of supraventricular tachycardia (SVT) were induced. The initiation of SVT was reproducibility dependent on a critical A-H interval prolongation. An early premature atrial contraction during ...
Masuda Ryo R Cardiology Division, Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, - - 2014
Although electrical thoracic vein (TV) isolation is an established strategy during atrial fibrillation (AF) ablation, discriminating TV potentials from far-field signals is critical for the achievement. One hundred consecutive drug-refractory symptomatic paroxysmal AF patients who underwent AF catheter ablation were included. All patients underwent circumferential pulmonary vein (PV) isolation during ...
Sharma Jayendra J From the *Divisions of Pediatric Cardiology and †Pediatric Intensive Care, Department of Pediatrics, Lincoln Medical and Mental health center, Bronx, - - 2014
Acute myopericarditis is primarily a pericarditic syndrome with variable myocardial involvement, as evidenced by elevated cardiac enzymes. It is a rare entity, exclusively seen in male adolescents and accounts for less than 2% of the cases of inpatient admissions for chest pain/pericarditis in the pediatric age group. The electrocardiographic changes ...
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