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Thooft Aurélie - - 2014
ABSTRACTA young woman presented with cardiac arrest following ingestion of yew tree leaves of the Taxus baccata species. The toxin in yew tree leaves has negative inotropic and dromotropic effects. The patient had a cardiac rhythm that alternated between pulseless electrical activity with a prolonged QRS interval and ventricular fibrillation. ...
Huntjens Peter R PR Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The - - 2014
It is unclear how the position of the left ventricular (LV) lead relative to a scar affects the haemodynamic response in patients with dyssynchronous heart failure receiving cardiac resynchronization therapy. We investigated this complex interaction using a computational model. The CircAdapt computational cardiovascular system model was used to simulate heart ...
Corino Valentina D A VD Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Golgi 39, 20133 Milano, Italy - - 2014
During atrial fibrillation (AF), conventional electrophysiological techniques for assessment of refractory period or conduction velocity of the atrioventricular (AV) node cannot be used. We aimed at evaluating changes in AV nodal properties during administration of metoprolol from electrocardiogram data, and to support our findings with simulated data based on results ...
Holzem Katherine M KM Department of Biomedical Engineering, Washington University, 390E Whitaker Hall, One Brookings Drive, St. Louis, MO 63130-4899, - - 2014
Human cardiac electrophysiology (EP) is a unique system for computational modelling at multiple scales. Due to the complexity of the cardiac excitation sequence, coordinated activity must occur from the single channel to the entire myocardial syncytium. Thus, sophisticated computational algorithms have been developed to investigate cardiac EP at the level ...
Fukushima Keiko K Department of Cardiology, Tokyo Women's Medical University, Tokyo, - - 2014
Atrial fibrillation (AF) is associated with atrial remodeling. We investigate the abilities of preprocedural echocardiographic parameters reflecting atrial remodeling to predict AF recurrence after radiofrequency catheter ablation (RFCA) for paroxysmal AF (PAF). Preprocedural echocardiographic parameters were measured during sinus rhythm in 105 patients with PAF undergoing RFCA. Electrical remodeling was ...
Kazbanov Ivan V IV Department of Physics and Astronomy, Ghent University, Ghent, - - 2014
Acute regional ischemia in the heart can lead to cardiac arrhythmias such as ventricular fibrillation (VF), which in turn compromise cardiac output and result in secondary global cardiac ischemia. The secondary ischemia may influence the underlying arrhythmia mechanism. A recent clinical study documents the effect of global cardiac ischaemia on ...
Liu Nan - - 2014
Fast and accurate risk stratification is essential in the emergency department (ED) as it allows clinicians to identify chest pain patients who are at high risk of cardiac complications and require intensive monitoring and early intervention. In this paper, we present a novel intelligent scoring system using heart rate variability, ...
Akbar Shahid S Research Center, Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, PO Box 6800, Buraidah 51452, Kingdom of Saudi Arabia. Tel. +966 (16) 3802267 Ext. 2330. E-mail. - - 2014
The invention of beta (β)-blockers culminated in a new era in the treatment of cardiovascular diseases (CD), and changed the course of pharmacology research for years to come. Since the introduction of propranolol into clinical practice in 1964, β-blockers enjoyed a special place in the clinicians' armamentarium against CDs, especially ...
von Lueder Thomas G TG Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Australia; Department of Cardiology B, Oslo University Hospital Ullevål, and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, - - 2014
-Angiotensin-receptor neprilysin inhibitors (ARNi), beyond blocking angiotensin II (AngII)-signalling, augment natriuretic peptides by inhibiting their breakdown by neprilysin (NEP). The myocardial effects of ARNi have been little studied until recently. We hypothesized that LCZ696 attenuates left ventricular (LV) remodeling after experimental myocardial infarction (MI), and that this may be contributed ...
Chen Wen-Pin WP Institute of Pharmacology, College of Medicine, National Taiwan University, - - 2014
Our previous study found that A83-01, a small molecule type 1 TGFβ receptor inhibitor, could induce proliferation of postnatal Nkx2.5+ cardiomyoblasts in vitro and enhance their cardiomyogenic differentiation. The present study addresses whether A83-01 treatment in vivo could increase cardiomyogenesis and improve cardiac function after myocardial infarction (MI) through an ...
Xu Jiefeng J 1Weil Institute of Critical Care Medicine, Rancho Mirage, CA. 2Department of Emergency Medicine, Yuyao People's Hospital, Medical School of Ningbo University, Ningbo, China. 3Keck School of Medicine of the University of Southern California, Los Angeles, CA. 4Department of Emergency Medicine, School of Medicine of the University of California, San Diego, - - 2014
Cardiac arrest and resuscitation are models of whole body ischemia reperfusion injury. Postresuscitation myocardial and cerebral dysfunction are major causes of high mortality and morbidity. Remote ischemic postconditioning has been proven to provide potent protection of the heart and brain against ischemia reperfusion injury. In this study, we investigated the ...
Wang J J Emergency and Intensive Care Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, - - 2014
Atrial fibrillation (AF) is one of the most common arrhythmia complications of acute coronary syndrome (ACS). The incidence of new-onset AF is 2.3-37 %, and it is an important predictor of a patient's morbidity, mortality, and prolonged hospitalization. Various risk factors for the development of new-onset AF after ACS have been ...
Salem Reda - - 2014
IntroductionThe occurrence of cardiac dysfunction is common after subarachnoid haemorrhage (SAH) and was hypothesized to be related to the release of endogenous catecholamines. The aim of this prospective study was to evaluate the relationship between endogenous catecholamine and cardiac dysfunction at the onset and during the first week after SAH.MethodsForty ...
Alhous M Hafez A MH Department of Cardiology, Aberdeen Royal Infirmary/University of Aberdeen, Aberdeen AB25 2ZN, UK - - 2014
To compare the effects on left ventricular (LV) function of right ventricular (RV) septal pacing vs. cardiac resynchronization therapy (CRT) in patients with an indication for the latter. Cardiac resynchronization therapy is an effective therapy in patients with drug-refractory heart failure. Despite advances in implantation techniques, LV lead placement can ...
März Imke I Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, - - 2014
Norwegian Forest cats (NFCs) are often listed as a breed predisposed to cardiomyopathy, but the characteristics of cardiomyopathy in this breed have not been described. The aim of this preliminary study was to report the features of NFC cardiomyopathy based on prospective echocardiographic screening of affected family groups; necropsy findings; ...
Kakroo Mashhood Ajaz MA Division of Cardiovascular Medicine, University of Toledo, Toledo, Ohio, - - 2014
Reverse Takotsubo cardiomyopathy (TCM) is a recently described variant of classic TCM. In contrast to classic TCM, the regional wall motion abnormalities are localized in the basal segments. The condition can be triggered by acute stressful events, including acute medical illnesses. The wall motion abnormalities and left ventricular dysfunction are ...
Nagao Michinobu M Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka City, Fukuoka, 812-8582, Japan, - - 2014
Iron deficiency and cardiac sympathetic impairment play a role in the worsening of heart failure, and these two conditions may be linked. The present study aimed to clarify the relationship between myocardial iron deficiency, cardiac sympathetic activity, and major adverse cardiac events (MACE) in patients with dilated cardiomyopathy (DCM). Cardiac ...
Jayawardena Tilanthi M TM Medicine, Duke University Medical - - 2014
Rationale: A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of micro-RNAs (miR combo) into the infarcted myocardium leads to ...
Baczkó István I Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged Dóm tér 12., 6720 Szeged, Hungary. - - 2014
Heart failure (HF) is a clinical syndrome characterized by significant impairment of cardiac ventricular function. Atrial fibrillation (AF) is the most commonly observed sustained arrhythmia in clinical practice. Both HF and AF are associated with increased morbidity and mortality and their prevalence increases with age. Approximately 50% of patients with ...
Wang Xule X Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan City 430060, People's Republic of China Cardiovascular Research Institute of Wuhan University, Wuhan City 430060, People's Republic of - - 2014
The aim of the present study was to explore the effect of renal sympathetic denervation (RSD) on the progression of paroxysmal atrial fibrillation (AF) in canines with long-term intermittent atrial pacing. Nineteen beagles were randomly divided into sham-operated group (six dogs), control group (six dogs), and RSD group (seven dogs). ...
Wildi Karin K Department of Cardiology, University Hospital Basel, Switzerland Department of Intensive Care, University Hospital Basel, - - 2014
In contrast to ST-elevation myocardial infarction (STEMI), in non-STEMI (NSTEMI) patients the need for continuous rhythm monitoring in a coronary care unit, respective incidence and timing of serious arrhythmias are poorly defined. We used a derivation-validation design and data from two independent prospective cohorts of consecutive haemodynamically stable NSTEMI patients ...
Garcia Santiago S Santiago Garcia, Minneapolis VA Healthcare System, University of Minnesota, MN 55417, United - - 2014
Cardiovascular disease is the leading cause of death in patients with peripheral arterial disease (PAD). Coronary artery disease (CAD) is highly prevalent, and often times coexist, in patients with PAD. The management of patients with PAD that requires a high-risk vascular surgical procedure for intermittent claudication, critical limb ischemia or ...
Hofmann Nina Patricia NP Nina Patricia Hofmann, Hugo A Katus, Grigorios Korosoglou, Department of Cardiology, University of Heidelberg, 69120 Heidelberg, - - 2014
Quantitative assessment of myocardial perfusion by myocardial blush grade (MBG) is an angiographic computer-assisted method to assess myocardial tissue-level reperfusion in patients with acute coronary syndromes and microvascular integrity in heart transplant recipients with suspected cardiac allograft vasculopathy. This review describes the ability of quantitative MBG as a simple, fast ...
Uribarri Aitor A Cardiology Department, Hospital General Universitario 'Gregorio Marañón', Madrid, Spain - - 2014
Little is known about the role of time to initiation of therapeutic hypothermia and time to target temperature (TTT) in the prognosis of patients resuscitated from cardiac arrest. A retrospective analysis was performed in 145 survivors of cardiac arrest who underwent therapeutic hypothermia between January 2003 and January 2013. The ...
Abd El Rahman Mohamed M 1Department of Pediatric Cardiology,Saarland University - - 2014
Background: We aimed to assess biatrial size and function, interactions on atrial and ventricular levels, and atrio-ventricular coupling in patients after tetralogy of Fallot repair. Methods: A total of 34 patients with a mean age of 20.9±9 years, and 35 healthy controls, underwent two-dimensional speckle tracking echocardiography for ventricular and ...
Matsuhisa Hironori H Department of Cardiovascular Surgery, Kobe Children's - - 2014
Background:The importance of ventricular pacing site in pediatric pacemaker therapy has gradually become recognized. We reviewed our experience with a left ventricular (LV)-prioritized pacing strategy.Methods and Results:Between 2000 and 2012, 60 patients underwent 76 permanent pacemaker implantations. Eight of the 29 reoperations involved ventricular lead repositioning for pacing-induced ventricular dysfunction. Freedom from ...
Stembridge Mike M Cardiff School of Sport, Cardiff Metropolitan University, Cardiff, UK - - 2014
Both short-term and life-long high altitude (HA) exposure challenge the cardiovascular system to meet the metabolic demand for oxygen (O2) in a hypoxic environment. As the demand for O2 delivery increases during exercise, the circulatory component of oxygen transport is placed under additional stress. Acute adaptation and chronic remodelling of ...
Pellicori Pierpaolo P Department of Cardiology, Castle Hill Hospital, Hull York Medical School (at University of Hull), Kingston Upon Hull HU16 5JQ, UK pierpaolo.pellicori@hey.nhs.uk - - 2014
Left atrial (LA) volume is an important marker of cardiac dysfunction and cardiovascular outcome in heart failure (HF), but LA function is rarely measured. Left atrial emptying function (LAEF), its clinical associations and prognostic value was studied in outpatients referred with suspected HF who were in sinus rhythm and had ...
Hummel Yoran M YM Department of Cardiology, University Medical Center Groningen, University of Groningen , Groningen , The - - 2014
Background. Cardiac morbidity is an important late effect in long-term childhood cancer survivors (CCS) treated with cardiotoxic agents or radiotherapy (RT) on the chest. However, there is limited data on the long-term cardiac sequelae in CCS who only received cranial RT. We hypothesized that cranial RT might negatively influence cardiac ...
Liu Xuan X Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
The performance of cardiac indicators as determinants of stroke outcomes remains debatable, therefore the present study focused on the short-term prognostic value of cardiac indicators in patients who had experienced acute ischaemic stroke. Consecutive patients with acute ischaemic stroke were enrolled in a prospective stroke registry. Data on demographics, clinical ...
Haugaard M M MM Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, - - 2014
Only few pharmacologic compounds have been validated for treatment of atrial fibrillation (AF) in horses. Studies investigating the utility and safety of flecainide to treat AF in horses have produced conflicting results, and the antiarrhythmic mechanisms of flecainide are not fully understood. To study the potential of flecainide to terminate ...
Nakamura K K Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Veterinary Teaching Hospital, Sapporo, Hokkaido, - - 2014
A strong correlation between left atrial (LA) dysfunction and the severity of cardiac disease has been described in human patients with various cardiac diseases. The role of LA dysfunction in dogs with chronic mitral valvular heart disease (CMVHD) has not been addressed. To investigate the correlation between LA function and ...
Huang Ying Y Pu Dong New Area People's Hospital, Department of Cardiology , Huan-Nan Road 490#, Shanghai, 201200 , China +86 021 50331692 ; +86 021 50331692 ; - - 2014
Background: Although few microRNAs (miRNAs) have been involved in the regulation of post-ischemic cardiac fibrosis, the exact effect and underlying mechanism of miRNAs in cardiac fibrosis remains unclear. Here, we sought to investigate whether microRNA-34 (miR-34) plays a role in the pathogenic development of myocardial fibrosis. Methods: The myocardial infarction ...
Hwang Minki - - 2014
The heart characteristic length, the inverse of conduction velocity, and the inverse of the refractory period are known to determine vulnerability to cardiac fibrillation (fibrillation number, FibN) in in-silico or ex vivo models. The purpose of this study was to validate the accuracy of FibN through in-silico atrial modeling and ...
Strom Joshua J Department of Pharmacology; College of Medicine, University of Arizona, 1501 N. Campbell Ave, Tucson, AZ, 85724, - - 2014
Dodecafluoropentane emulsion (DDFPe) is a perfluorocarbon with high oxygen dissolving, transport, and delivery capacity that may offer the potential to limit ischemic injury prior to clinical reperfusion. Here we investigated the cardiac protective potential of DDFPe in a mouse model of myocardial infarction. Myocardial infarction was initiated by permanent ligation ...
Patra C - - 2014
Cardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness ...
Pokharel Parash P Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, 1650 Grand Concourse, 12th Floor, Bronx, NY 10457, - - 2014
Left ventricular (LV) torsion (twisting) and untwisting results in equalization of wall stress and augmentation of pressure generated for a given shortening of sarcomere during the systolic contraction and aids early diastolic relaxation. This is attributed to the dynamic interaction of epicardial and endocardial helical myocardial fibers. Recent advances in ...
Perugu S S Harbor-UCLA Medical Center, Torrance, CA, - - 2014
Evaluate plasma markers of myocardial function and ischemia [B-type natriuretic peptide] (BNP) and cardiac troponin T (cTnT)] in relationship to echocardiographic indices of left ventricular (LV) function and severity of illness score (SNAPPE-II) in Very-Low-Birth-Weight-Infants (VLBWIs) prospectively. Serial echocardiography studies, clinical data, BNP and cTnT were obtained in thirty VLBWIs ...
Chandraprakasam Satish S The Cardiac Center of Creighton University, 3006 Webster Street, Omaha, NE, 68131, USA, - - 2014
Heart failure (HF) continues to grow and affect more than five million people in the USA. One of the leading device therapies in HF is cardiac resynchronization therapy (CRT) which has been studied for over 20 years. Recent advancements in lead placement, lead technology, patient selection, and CRT optimization by electrical ...
Mafi Rad Masih M Maastricht University Medical Centre, Department of Cardiology, PO Box 5800, 6202 AZ, Maastricht, the - - 2014
Current targeted left ventricular (LV) lead placement strategy is directed at the latest activated region during intrinsic activation. However, cardiac resynchronization therapy (CRT) is most commonly applied by simultaneous LV and right ventricular (RV) pacing without contribution from intrinsic conduction. Therefore, targeting the LV lead to the latest activated region ...
Morris Daniel A DA Department of Cardiology, Charité University Hospital, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany, - - 2014
The aim of this study was to test the hypothesis that in patients with Fabry disease, 2D speckle-tracking echocardiography (2DSTE) could detect functional myocardial alterations such as left ventricular (LV), right ventricular (RV), and left atrial (LA) dysfunction, even when conventional cardiac measurements are normal. In addition, we hypothesized that ...
Borgeat K K Royal Veterinary College, Hatfield, UK; Highcroft Veterinary Referrals, Bristol, - - 2014
The use of cardiac biomarkers to assist in the diagnosis of occult and symptomatic hypertrophic cardiomyopathy (HCM) in cats has been established. There is limited data describing their prognostic utility in cats with HCM. Circulating concentrations of N-terminal B-type natriuretic peptide (NTproBNP) and cardiac troponin I (cTnI) predict cardiac death ...
Lenarczyk Radosław R From the Department of Cardiology, Congenital Heart Disease and Electrotherapy, Silesian Medical University, Silesian Centre for Heart Diseases, Zabrze, - - 2014
The prognostic impact of improvement in health-related quality of life (QoL) and its relation to response in cardiac resynchronization therapy (CRT) recipients remains unknown. To assess the correspondence between response to CRT and improvements in QoL and to verify if a change in QoL after pacing influences outcome in CRT ...
Rong Jie J Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, ‡State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, §Synthetic and Functional Biomolecules Center, and ∥Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871, - - 2014
In the heart, glycosylation is involved in a variety of physiological and pathological processes. Cardiac glycosylation is dynamically regulated, which remains challenging to monitor in vivo. Here we describe a chemical approach for analyzing the dynamic cardiac glycome by metabolically labeling the cardiac glycans with azidosugars in living rats. The ...
Lee Justin M S - - 2014
Focal atrial tachycardias arise preferentially from specific locations within the atria. Careful analysis of the P wave can provide useful information about the chamber and likely site of origin within that chamber. Macro-reentrant atrial flutter also tends to occur over a limited number of potential circuits. In this case, the ...
Traykov Vassil B VB Clinic of Cardiology, Tokuda Hospital - Sofia, N.Vaptzarov blvd. 51B, 1407 Sofia, Bulgaria.. - - 2014
Determining the chamber of origin of focal atrial tachycardias (FATs) arising at or close to the septum might require biatrial mapping. This review focuses on the available tools and methods used to distinguish right atrial from left atrial origin before left atrial access is obtained. These include analysis of P ...
Taylor Colleen M - - 2014
Focal atrial tachycardias arising from the atrial appendages and the aortic sinuses of Valsalva are less frequently encountered in clinical practice. This review article describes the clinical presentation, surface P wave morphology, electrophysiologic characteristics and treatment of these arrhythmias. Catheter ablation of these focal tachycardias has a high success rate. ...
Kohári Mária - - 2014
Atrial tachycardias are common after open heart surgery. Most commonly these are macro-reentrant including cavotricuspid isthmus dependent atrial flutter, incisional right atrial flutter and left atrial flutter. Focal atrial tachycardias occur less frequently. The specific type of atrial tachycardia highly depends on the type of surgical incision. Catheter ablation can ...
Sághy László L 2nd Department of Internal Medicine and Cardiology Centre, University of Szeged, Korányi fasor 6. 6724 Szeged, Hungary.. - - 2014
One of the most important proarrhythmic complications after left atrial (LA) ablation is regular atrial tachycardia (AT) or flutter. Those tachycardias that occur after atrial fibrillation (AF) ablation can cause even more severe symptoms than those from the original arrhythmia prior to the index ablation procedure since they are often ...
Rosso Raphael R Tel-Aviv Sourasky Medical Center, Tel-Aviv, - - 2014
-The magnitude of QT-prolongation in response to bradycardia, rather than the bradycardia per-se, determines the risk for torsade-de-pointes (TdP) during atrio-ventricular block (AVB). However, we do not know why some patients develop more QT prolongation than others despite similar bradycardia. We hypothesized that in patients who develop significant QRS-vector changes ...
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