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Mason Keira P KP Department of Anaesthesia, Harvard Medical School, Boston Children's Hospital, Boston, MA, - - 2014
According to Wikipedia, the word 'bradycardia' stems from the Greek βραδύς, bradys, 'slow', and καρδία, kardia, 'heart'. Thus, the meaning of bradycardia is slow heart rate but not necessarily too slow heart rate. If looking at top endurance athletes they may have a resting heart rate in the very low ...
Sun Ji-Min JM Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. - - 2014
Cardiac hypertrophy is a compensatory mechanism that occurs in conjunction with cardiovascular diseases. Although hypertrophy of the myocardium provides certain benefits during the early stages of cardiovascular disease, prolonged hypertrophy is potentially harmful to the heart and can result in arrhythmia and heart failure. The aim of this study was ...
Werner Gerald S GS Medizinische Klinik I (Cardiology & Intensive Care), Klinikum Darmstadt GmbH, Darmstadt, - - 2014
Percutaneous coronary intervention for chronic total coronary occlusions (CTO) becomes increasingly more complex with the transcollateral retrograde approach. This study assesses the effect of the retrograde approach on markers of ischaemia and clinical events. Four hundred and ninety-two consecutive procedures in 392 patients were prospectively evaluated. Before and within 18-24 ...
Jones Michael A MA From the Cardiology Department, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Headington, Oxfordshire, - - 2014
Quadripolar left ventricular pacing leads permit a variety of pacing configurations from different sites within a coronary vein. There may be advantages to selecting a specific pacing vector. This study examines whether the range of cardiac outputs obtained at cardiac resynchronization therapy (CRT) implantation is greater between different poles within ...
Lee Byung Kook BK Department of Emergency Medicine, Chonnam National University Hospital, 42, Jebong-ro, Donggu, Gwangju, Republic of Korea. Electronic address: - - 2014
Ischaemic contracture compromises the haemodynamic effectiveness of cardiopulmonary resuscitation and resuscitability. 2,3-Butanedione monoxime (BDM) reduced ischaemic contracture by inhibiting actin-myosin crossbridge formation in an isolated heart model. We investigated the effects of BDM on ischaemic contracture and resuscitation outcomes in a pig model of out-of-hospital cardiac arrest (OHCA). After 15min ...
Bartos Jason A JA Department of Medicine-Cardiovascular Division, University of - - 2014
Ischemic postconditioning (stutter CPR) and sevoflurane have been shown to mitigate the effects of reperfusion injury in cardiac tissue after 15minutes of ventricular fibrillation (VF) cardiac arrest. Poloxamer 188 (P188) has also proven beneficial to neuronal and cardiac tissue during reperfusion injury in human and animal models. We hypothesized that ...
Balzer Felix - - 2014
BackgroundSeveral animal studies suggest beneficial effects on kidney function upon administration of levosimendan. As recent data from clinical studies are heterogeneous, we sought to investigate whether levosimendan is associated with improved postoperative kidney function in cardiac surgery patients with respect to timing of its administration.MethodsRetrospective, single centre, observational analysis at ...
Benhamou Ygal Y Service de Médecine Interne, CHU Charles Nicolle, Rouen; Inserm U1096, Rouen, France; Centre de Référence des Microangiopathies Thrombotiques, Hôpital Saint-Antoine, AP-HP, - - 2014
Background. Cardiac involvement is a major cause of mortality in thrombotic thrombocytopenic purpura (TTP). However, diagnosis remains underestimated and delayed due to sub-clinical injuries. Cardiac troponin-I (cTnI) on admission could improve early diagnosis of cardiac involvement and have a prognostic value. Objectives. To assess the predictive value of cTnI-I in ...
Karagiannakis Dimitrios S DS Department of Gastroenterology, Medical School of Athens University, Laiko General Hospital, 17 Agiou Thoma Street, 11527, Athens, Greece, - - 2014
Cirrhotic cardiomyopathy, a cardiac dysfunction presented in patients with cirrhosis, represents a recently recognized clinical entity. It is characterized by altered diastolic relaxation, impaired contractility, and electrophysiological abnormalities, in particular prolongation of the QT interval. Several mechanisms seem to be involved in the pathogenesis of cirrhotic cardiomyopathy, including impaired function ...
Oura Trisha J TJ Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, - - 2014
Conflicting information has been published regarding the cause of a valentine-shaped cardiac silhouette in dorsoventral or ventrodorsal thoracic radiographs in cats. The purpose of this retrospective, cross-sectional study was to test the hypothesis that the valentine shape is primarily due to left atrial enlargement. Images for cats with a radiographic ...
Später Daniela D Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, 7 Divinity Avenue, Cambridge, MA 02138, USA Department of Bioscience, CVMD iMED, AstraZeneca, Pepparedsleden 1, Mölndal 43150, Sweden daniela.spaeter@astrazeneca.com - - 2014
During development, cardiogenesis is orchestrated by a family of heart progenitors that build distinct regions of the heart. Each region contains diverse cell types that assemble to form the complex structures of the individual cardiac compartments. Cardiomyocytes are the main cell type found in the heart and ensure contraction of ...
Rosman Lindsey L East Carolina University, Department of Psychology, United - - 2014
Survival from cardiac arrest is a medical success but simultaneously produces psychological challenges related to perception of safety and threat. The current study evaluated symptoms of cardiac-specific anxiety in sudden cardiac arrest (SCA) survivors and examined predictors of cardiac anxiety secondary to cardiac arrest. A retrospective, cross-sectional study of 188 ...
Sassi Yassine - - 2014
Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained β-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure. Here, we have demonstrated that export of cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress. We report ...
Ramdjan Tanwier Ttk - - 2014
The incidence of sick sinus syndrome will increase due to population ageing. Consequently, this will result in an increase in the number of pacemaker implantations. The atrial lead is usually implanted in the right atrial appendage, but this position may be ineffective for prevention of atrial fibrillation. It has been ...
Colbert Gates G Division of Nephrology - - 2014
Cardiac biomarkers, such as cardiac troponin T (cTnT), brain natriuretic peptide (BNP), and N-terminal-pro-BNP (NT-pro-BNP), are commonly used to diagnose acute coronary syndrome and congestive heart failure exacerbation in symptomatic patients. Levels of these biomarkers are frequently chronically elevated in asymptomatic patients with ESRD who are receiving maintenance dialysis. Other ...
Cittadini Francesca F Institute of Public Health, Section of Legal Medicine, Catholic University, Rome, - - 2014
Cocaine and alcohol toxicity is well known, especially when simultaneously abused. These drugs perform both acute and chronic harmfulness, with significant cardiac events such as ventricular arrhythmias, tachycardia, systemic hypertension, acute myocardial infarction, ventricular hypertrophy, and acute coronary syndrome. The present report refers about a patient who died after a ...
Thomas Tamara O TO The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2033, Cincinnati, OH, 45229, USA, - - 2014
Cardiac manifestations of Duchenne muscular dystrophy (DMD) include progressive cardiac dysfunction and an elevated resting heart rate (HR). We hypothesized this elevated HR reflects autonomic dysfunction that can be identified by heart rate variability (HRV) analyses which will be associated with myocardial fibrosis by cardiac magnetic resonance imaging (cMR). DMD ...
Boriani Giuseppe G aInstitute of Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, S. Orsola-Malpighi University Hospital, Bologna, Italy bCentre for Cardiovascular Sciences, Queen Elizabeth Hospital, University of Birmingham, Birmingham, - - 2014
The Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block (BLOCK HF) trial, published in April 2013 [Curtis AB, Worley SJ, Adamson PB, et al; Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block (BLOCK HF) Trial Investigators. Biventricular pacing for atrioventricular block and ...
Milano G G Head Oncopharmacology Unit and EA UNS 3836 Centre Antoine Lacassagne 33 Av Valombrose 06189 Nice Cedex 2 France. - - 2014
Optimal identification of the risk of developing cardiotoxicity upon trastuzumab (TZM) treatment appears necessary as this risk may impair treatment compliance and compromise long-term recovery. To better understand and predict cardiac toxicity, the molecular mechanisms underlying this phenomenon need to be known. HER2 is present at the cell surface of ...
Su M M State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, - - 2014
MicroRNAs have emerged as crucial regulators of cardiac homeostasis and remodeling in various cardiovascular diseases. We previously demonstrated that miR-221 regulated cardiac hypertrophy in vitro. In the present study, we demonstrated that the cardiac-specific overexpression of miR-221 in mice evoked cardiac dysfunction and heart failure. The lipidated form of microtubule-associated ...
Hickman Peter E PE ACT Pathology , Garran, ACT , Australia - - 2014
Abstract Cardiac troponin is the preferred biomarker for defining the acute coronary syndrome and acute myocardial infarction. Currently, the only decision limit formally endorsed with regard to the cardiac troponins is the 99th percentile. This is a "rule-in" criterion, intended to ensure that only persons with the acute coronary syndrome ...
Hua Wei W Arrhythmic Center and Clinical EP Lab, Beijing Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Beijing 100037, - - 2014
T-wave alternans (TWA) represents myocardial instability. The present study was to determine the impact of cardiac resynchronization therapy (CRT) on TWA and left ventricular ejection fraction (LVEF) in heart failure patients. T-wave alternans was analysed using a spectral method in 27 CRT-ICD patients. Ambulatory device electrograms were collected and LVEF ...
Bub Gil G Department of Physiology Anatomy and Genetics, University of Oxford, OX1 3PT, UK - - 2014
The autonomic nervous system plays an important role in the modulation of normal cardiac rhythm, but is also implicated in modulating the hearts susceptibility to re-entrant ventricular and atrial arrhythmias. The mechanisms by which the autonomic nervous system is pro-arrhythmic or anti-arrhythmic is multifaceted and varies for different types of ...
Gassanov Natig N Natig Gassanov, Fikret Er, Department of Internal Medicine I, Klinikum Gütersloh, 33332 Gütersloh, - - 2014
Cardiac dysfunction is frequently observed in patients with cirrhosis, and has long been linked to the direct toxic effect of alcohol. Cirrhotic cardiomyopathy (CCM) has recently been identified as an entity regardless of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation is a pathophysiological hallmark of the disease. ...
de Bakker Desiderius M DM Department of Anatomy, Embryology & Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the - - 2014
Caecilians (order Gymnophiona) are elongate, limbless, snake-like amphibians that are the sister-group (closest relatives) of all other recent amphibians (frogs and salamanders). Little is known of their cardiovascular anatomy and physiology, but one nearly century old study suggests that Hypogeophis (family Indotyphlidae), commonly relied upon as a representative caecilian species, ...
Fikrle Michal M 2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech - - 2014
The non-invasive assessment of amyloid heart disease may be challenging. Cardiac magnetic resonance (CMR) represents a method of choice for assessment of left ventricular (LV) morphology and function, and it also provides a unique possibility to evaluate the presence of amyloid deposition by the late gadolinium enhancement (LGE) technique. However, ...
Rickard John J Johns Hopkins University, Division of Cardiology/Electrophysiology. Electronic address: - - 2014
A minority of patients undergoing cardiac resynchronization therapy (CRT) utilize a surgically placed epicardial left ventricular (SPELV) pacing lead. Prior studies of outcomes in patients receiving such leads have been limited to small cohorts with limited follow up. We sought to compare outcomes in patients receiving a SPELV pacing lead ...
Levi M M Division of Cardiology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada - - - 2014
The majority of patients with end--stage renal disease have chronically elevated concentrations of troponins, thus obscuring the diagnosis of myocardial infarction. We conducted a prospective study to examine the impact of hemodialysis on the level of high--sensitivity cardiac troponins T in asymptomatic patients with end--stage renal disease. High--sensitivity cardiac troponins ...
Song Guixian G Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, - - 2014
Induced pluripotent stem cells (iPSc) hold significant promise for the development of cardiac regenerative therapy for myocardial infarction (MI). However, preclinical optimization and validation of large-animal models will be required before iPSc used clinically. Therefore, we aim to investigate the therapeutic potential of iPSc transplantation for MI and relative mechanisms ...
Mohammed Selma F SF Mayo Clinic, Rochester, MN - - 2014
-The prevalence and clinical significance of right ventricular (RV) systolic dysfunction (RVD) in patients with heart failure and preserved EF (HFpEF) are not well characterized. -Consecutive, prospectively identified HFpEF (Framingham HF criteria, EF ≥50%) patients (N=562) from Olmsted County, Minnesota underwent echocardiography at HF diagnosis and follow-up for cause specific ...
Berent Robert R Center for Cardiovascular Rehabilitation, HerzReha Bad Ischl, Gartenstrasse 9, 4820 Bad Ischl, Austria. - - 2014
Right ventricular apical pacing (RVAP) with a left bundle branch block on the electrocardiogram may result in regional wall motion abnormalities and decreased left ventricular function (LVF). Furthermore, perfusion defects in dipyridamole technetium-99m-methoxisobutylisonitrile ((99m)Tc-MIBI) myocardial perfusion imaging may occur despite a normal coronary angiogram. In a 68 years old patient, ...
Seki Akiko A Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; Support Center for Women Health Care Professionals and Researchers, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: - - 2014
Epigenetic factors of pressure load, fluid force, and electrical fields that occur during cardiac contraction affect cardiac development, morphology, function, and pathogenesis. These factors are orchestrated by intercellular communication mediated by gap junctions, which synchronize action potentials and second messengers. Misregulation of the gap junction protein connexin (Cx) alters cardiogenesis, ...
Woo Jennifer Susan JS a David Geffen School of Medicine at - - 2014
Abstract Diabetic embryopathy refers to a constellation of congenital malformations arising in the setting of poorly controlled maternal diabetes mellitus. Cardiac abnormalities are the most frequently observed findings, with a five-fold risk over normal pregnancies. While a diverse spectrum of cardiac defects has been documented, cardiac non-compaction morphology has not ...
Oliveira Júnior Roberto Márcio de RM Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, - - 2014
Background: Isolated congenital atrioventricular block (CAVB) is a rare condition with multiple clinical outcomes. Ventricular remodeling can occur in approximately 10% of the patients after pacemaker (PM) implantation. Objectives: To assess the functional capacity of children and young adults with isolated CAVB and chronic pacing of the right ventricle (RV) ...
Lobo Tasso Julio TJ Serviço de Arritmias - Eletrofisiologia e Marca-passo, Hospital do Coração de São Paulo Hcor, São Paulo, SP, - - 2014
Background: Heart failure and atrial fibrillation (AF) often coexist in a deleterious cycle. Objective: To evaluate the clinical and echocardiographic outcomes of patients with ventricular systolic dysfunction and AF treated with radiofrequency (RF) ablation. Methods: Patients with ventricular systolic dysfunction [ejection fraction (EF) <50%] and AF refractory to drug therapy ...
Zaman Junaid A B JA aNational Heart and Lung Institute, Imperial College London, UK bDepartment of Medicine, University of California San Diego, San Diego, California, - - 2014
Rotors have long been postulated to drive atrial fibrillation, but evidence has been limited to animal models. This changed recently with the demonstration using focal impulse and rotor modulation (FIRM) mapping that rotors act as human atrial fibrillation sources. This mechanistic approach to diagnosing the causes of atrial fibrillation in ...
Aizawa Yoshifusa Y Tachikawa Medical Center/Niigata University. Nagaoka/Niigata, Japan. Electronic address: - - 2014
J waves can be observed in individuals of the general population, but ECG characteristics are poorly understood. To characterize the J wave dynamicity in a general patient population. The response of J waves (>0.1 mV above the isoelectric line in two contiguous leads) to varying RR intervals was analyzed. Patients ...
Nadir M Adnan MA Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, Dundee, Scotland, United Kingdom. Electronic address: - - 2014
The purpose of this study was to identify the relationship of B-type natriuretic peptide (BNP) with evolution of left ventricular mass (LVM) in optimally treated primary prevention patients. Patients who have an elevated BNP no cardiac abnormality on echocardiography are common and at increased risk of adverse events. One hypothesis ...
Seo Hong-Joo HJ Department of Thoracic and Cardiovascular Surgery, Chosun University Hospital , Gwangju , Republic of Korea - - 2014
Abstract This study aimed to determine the association of the brachial-ankle pulse wave velocity (baPWV) and mean platelet volume (MPV) with the development of adverse outcomes after percutaneous coronary intervention (PCI). The baPWV and MPV were analyzed in 372 patients who underwent PCI, with the primary endpoint as cardiac death. ...
Sharma Sanjay S Department of Cardiovascular Sciences, St George's University of London, London, - - 2014
Deaths of young athletes from cardiac disease are uncommon but receive considerable media attention and intermittently galvanize debates about cardiac screening prior to participation in sports. Both the American Heart Association (AHA) and European Society of Cardiology (ESC) endorse preparticipation screening in athletes; however, there is disagreement about the best ...
Kim Sung-Hwan SH Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, South - - 2014
The selection of the optimal right ventricular (RV) pacing site remains unclear. We hypothesized that a normal paced QRS axis would provide a physiological ventricular activation and lead to a better long-term outcome. We evaluated 187 patients who underwent a permanent pacemaker implantation and were dependent on RV pacing. The ...
Mitra Arkadeep A Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, - - 2014
Cardiac hypertrophy and myocardial infarction (MI) are two etiologically different disease forms with varied pathological characteristics. However, the precise molecular mechanisms and specific causal proteins associated with these diseases are obscure to date. In this study, a comparative cardiac proteome profiling was performed in Wistar rat models for diseased and ...
Nomura Akihiro A Division of Cardiovascular Medicine, Kanazawa University Graduate School of - - 2014
Background:Although fragmented QRS complex (frag-QRS) reflecting intra-ventricular conduction delay has been shown to be a prognostic marker for cardiac events, few data exist regarding the impact of frag-QRS on cardiac events in hypertrophic cardiomyopathy (HCM).Methods and Results:Ninety-four HCM patients (56 male; mean age, 58±17 years) were retrospectively investigated. Frag-QRS was defined as ...
Jorfida Marcella M aDivision of Cardiology, Cardiovascular and Thoracic Department, 'Città della Salute e della Scienza' Hospital and Department of Medical Sciences bStroke Unit, 'Città della Salute e della Scienza' Hospital and University of Turin, Turin, - - 2014
Atrial fibrillation is responsible for up to one-third of ischemic strokes, and is also associated with silent cerebral infarctions and transient ischemic attacks (TIAs). The self-terminating and often asymptomatic nature of paroxysmal atrial fibrillation (PAF) may lead to its underdiagnosis. A continuous and long-term heart rhythm monitoring can be useful ...
Solecki Kamila - - 2014
Abstract Background: Cardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity ...
Brembilla-Perrot Béatrice B Department of Cardiology, University Hospital of Brabois, Vandoeuvre, France. Electronic address: - - 2014
To identify clinical factors associated with the probability for each arrhythmic mechanism causing recurring symptoms after atrioventricular nodal re-entrant tachycardia (AVNRT) ablation. Slow pathway radiofrequency ablation is used to treat AVNRT. After ablation, recurrence of symptoms due to AVNRT or other arrhythmias can occur. We studied 835 patients successfully treated ...
Glavinovic Tamara - - 2014
Left ventricular non compaction is a relatively rare congenital disorder characterized by prominent trabeculations and intertrabecular recesses with the potential for thromboembolism, arrhythmias, and sudden cardiac death as adverse effects. Echocardiography has traditionally been employed as the primary mode of imaging; however, with the advent of cardiac magnetic resonance as ...
El-Sherif Nabil N SUNY Downstate Medical Center, Brooklyn, NY; NY Harbor VA Healthcare System, Brooklyn, - - 2014
The aim of the study is to contrast the role of conventional ambulatory electrocardiographic monitoring (AEM) artifacts with a less emphasized problem with potentially more serious implications, that is, the failure to recognize, and therefore misinterpret, a genuine arrhythmia episode in the AEM recording. The study material included 500 Holter ...
Plymen Carla M CM Department of Adult Congenital Heart Disease and Electrophysiology, The Heart Hospital, University College London Hospitals NHS Foundation Trust, 16-18 Westmoreland St, London W1G 8PH, UK UCL Institute of Child Health, London, - - 2014
The purpose of this study was to create an epicardial electroanatomic map of the right ventricle (RV) and then apply post-operative-targeted single- and dual-site RV temporary pacing with measurement of haemodynamic parameters. Cardiac resynchronization therapy is an established treatment for symptomatic left ventricular (LV) dysfunction. In congenital heart disease, RV ...
Santini L L Department of Cardiology, University of Tor Vergata, Rome, Italy - - - 2014
Quadripolar left ventricular (LV) leads offer multiple choices for LV pacing increasing programming flexibility. Aim of this study is to assess the influence of LV pacing vector selection on hemodynamic parameters for patients who underwent cardiac resynchronization therapy (CRT) using quadripolar LV lead chronically evaluated with a non--invasive approach by ...
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