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Kang Dong-Wha - - 2009
BACKGROUND AND PURPOSE: Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging after acute ischemic stroke have been suggested as a potential marker of early recurrent stroke. We hypothesized that biomarkers of inflammation or coagulation may be associated with the pathogenesis of ERILs and sought to investigate whether these biomarkers provide ...
Jang Sung Ho - - 2009
Diffusion tensor tractography allows the visualization of the corticospinal tract (CST). In the current study, we attempted to demonstrate the preservation of the integrity of the CST within an infarct in a hemiparetic patient with a medulla infarct. A 76-yr-old male patient showed severe paralysis of the left extremities at ...
Weyrich Andrew S - - 2009
The recognition that stroke and other ischemic events are manifestations of chronic progressive inflammation has had a great impact on the development of prevention strategies. The most recent American Heart Association guidelines recommend combination aspirin and extended-release dipyridamole over aspirin alone for patients with prior ischemic stroke or transient ischemic ...
Hemmen Thomas M - - 2009
Induced hypothermia after ischemic stroke is a promising neuroprotective therapy and is the most potent in pre-clinical models. Technological limitations and homeostatic mechanisms that maintain core body temperature, however, have limited the clinical application of hypothermia. Advances in intravascular cooling and successful trials of hypothermia after global cerebral ischemia, such ...
Liang Zhijian - - 2009
BACKGROUND: Wallerian degeneration in pyramidal tract following supratentorial stroke has been detected by some studies using diffusion tensor imaging (DTI), but the Wallerian degeneration in middle cerebellar peduncle after pontine infarction and its potential clinical significance remain to be confirmed. METHODS: Seventeen patients with a recent focal pontine infarct underwent ...
Zhao P P Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, - - 2009
It is unknown if impaired cerebral vasoreactivity recovers after ischemic stroke, and whether it compromises perfusion in regions surrounding infarct and other vascular territories. We investigated the regional differences in CO2 vasoreactivity (CO2 VR) and their relationships to peri-infarct T2 hyperintensities (PIHs), chronic infarct volumes, and clinical outcomes. We studied ...
Kakkos Stavros K - - 2009
This study tested the hypothesis that silent embolic infarcts on computed tomography (CT) brain scans can predict ipsilateral neurologic hemispheric events and stroke in patients with asymptomatic internal carotid artery stenosis. In a prospective multicenter natural history study, 821 patients with asymptomatic carotid stenosis graded with duplex scanning who had ...
Schürks Markus - - 2009
Results from studies investigating the association between polymorphisms in the beta2-adrenergic receptor gene (ADRB2) and cardiovascular disease (CVD) are controversial. Using haplotype-based analysis, we have previously shown a protective effect of the Gly16-Gln27-Ile164 haplotype on myocardial infarction in men. We sought to replicate these findings in women and further investigated ...
Saba Luca - - 2009
OBJECTIVE: Several studies have shown that leukoaraiosis is a clinically relevant condition. Patients with leukoaraiosis have a negative prognosis in terms of death, stroke, and myocardial infarction. The aim of this study was to evaluate whether the presence and severity of leukoaraiosis correlate with degree of carotid stenosis and the ...
Ostergaard Leif - - 2009
Multimodal MRI provides powerful tools to study acute stroke pathophysiology and to guide stroke therapy. In particular, the perfusion-diffusion mismatch has been hypothesized as a target for treatment beyond the 3 h time window. Studies of infarct progression and of tissue oxygen metabolism suggest that infarct risk is extremely heterogeneous ...
Arboix Adrià - - 2009
Lacunar infarcts or small subcortical infarcts result from occlusion of a single penetrating artery and account for one quarter of cerebral infarctions. Patients with a lacunar infarct usually present with a classical lacunar syndrome (pure motor hemiparesis, pure sensory syndrome, sensorimotor stroke, ataxic hemiparesis or dysarthria-clumsy hand) and, less frequently, ...
- - 2009
Stroke is very common, with, for example, around 110,000 people each year in England alone experiencing a first or recurrent episode. Consequences of stroke can include disability and early death, and the condition costs the UK economy around 7 billion pounds annually. Around 70-80% of first strokes are ischaemic (i.e. ...
Bates Vernice - - 2009
This article addresses the common stroke problems seen in an outpatient or office setting, including transient ischemic attacks (TIAs), minor strokes and carotid stenoses. Expedited, semi-emergent evaluation and prompt appropriate treatment of acute TIAs and minor strokes reduces an otherwise significant risk for stroke. Evaluation requires good-quality neuroimaging, cardiac imaging, ...
Gasparotti R - - 2009
BACKGROUND AND PURPOSE: A potential role of perfusion CT (PCT) in selecting patients with stroke for reperfusion therapies has been recently advocated. The purpose of the study was to assess the reliability of PCT in predicting clinical outcome of patients with acute ischemic stroke treated with intra-arterial thrombolysis (IAT). MATERIALS ...
Nair P P - - 2009
INTRODUCTION: This study aimed to evaluate the pattern of infarct in basal ganglia region in tuberculous meningitis (TBM) and ischemic strokes and its sensitivity and specificity in the diagnosis of these disorders. METHODS: Patients with TBM and ischemic strokes in basal ganglia region were retrospectively evaluated from our tuberculous meningitis ...
Krane Vera - - 2009
In hemodialysis, applicable guidelines recommend regular electrocardiogram (ECG) recordings. However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis. The relationship between nine common baseline ECG variables and a combined cardiovascular endpoint (CVE; cardiac death, myocardial infarction, ...
Liu Fudong F Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, - - 2009
Considerable debate exists in the literature on how best to measure infarct damage and at what point after middle cerebral artery occlusion (MCAO) infarct is histologically complete. As many researchers are focusing on more chronic endpoints in neuroprotection studies it is important to evaluate histological damage at later time points ...
Bruno Askiel - - 2009
Long-term complications of hyperglycemia are well known, but short-term complications are not. Because hyperglycemia and hypoglycemia can be corrected relatively rapidly, it seems important to determine if such interventions during acute illnesses improve patient outcomes. In most animal stroke studies, animals with hyperglycemia before or during brain ischemia have worse ...
Paulinska P - - 2009
Plasma levels of von Willebrand factor (VWF) are increased in patients with cardiovascular risk factors. Various studies aimed to elucidate the relation of VWF with thromboembolic cardiovascular events, ischaemic stroke as well as with peripheral arterial occlusive disease. In the general population, there is only a weak association between VWF ...
Borsody Mark - - 2009
BACKGROUND: Cerebral infarction involving the insula has been associated with decreased survival following stroke. We hypothesized that infarct volume may reduce this association. METHODS: The subjects were acute stroke patients who had consented to 2-year follow-up after stroke as part of the Michigan Acute Stroke Care Overview and Treatment Surveillance ...
Dias Vasco - - 2009
Neuromediated stunned myocardium is a well-known complication of subarachnoid hemorrhage but has rarely been reported in association with other central nervous system disorders. The pathophysiology of this entity remains unclear, but a catecholamine-induced neurocardiogenic injury has been proposed as a causal factor. Typically, patients have rapid full cardiovascular recovery within ...
Elkind Mitchell S V - - 2009
Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors of stroke risk and prognosis. Infections may also precipitate stroke. Medications, especially hydroxymethylglutaryl coenzyme A ...
Tang W K - - 2009
Frontal and basal ganglia infarcts and executive dysfunction are thought to be involved in the pathophysiology of poststroke emotional incontinence (PSEI). The study examined whether patients with PSEI have more frontal and/or basal ganglia infarcts and impairment in executive function. A total of 516 Chinese patients with acute ischemic stroke ...
Al Khalaf Mohamad M - - 2009
BACKGROUND AND OBJECTIVE: Angiotensin II type 1 receptor antagonists (ARBs) are widely used as a substitute for angiotensin-converting enzyme inhibitors (ACEIs) to treat patients without heart failure, but their effect on cardiovascular morbidity and mortality has not been clearly determined. A systematic review and meta-analysis was undertaken to determine the ...
Brouns Raf - - 2009
INTRODUCTION: We investigated the predictive value of standard neurological evaluation, a commercially available biomarker assay and neuroimaging in the subacute phase for outcome after thrombolytic therapy in ischemic stroke. METHODS: Thirty-four consecutive ischemic stroke patients were evaluated by means of the NIH Stroke Scale (NIHSS(72)), the Triage(R) Stroke Panel (MMX(72)) ...
Nazzal Mahmoud Ezzat - - 2009
PURPOSE: To establish, using brain spiral computerised tomography (SCT) and modified Barthel index (MBI), whether the location of cerebral infarction could be correlated with functional outcome in acute ischemic stroke patients who undergo early intensive rehabilitation. METHODS: Observational cohort, assessor blinded and correlational prospective 12-weeks study that included 111 acute ...
Kumar Sudhir - - 2009
Diaphragmatic palsy in hemiparetic stroke is not well recognized. Further, its implications on stroke outcome have not been studied. Here, we report a patient with left-sided diaphragmatic palsy due to an acute right middle cerebral artery territory infarction. The diagnosis was suspected on finding an elevated dome of the diaphragm ...
Pandian Jeyaraj Durai - - 2009
Thrombolytic stroke therapy is based on the "re-canalization hypothesis," i.e., that reopening of occluded vessels improves clinical outcome in acute ischemic stroke through regional reperfusion and salvage of threatened tissues. Re-canalization is an important predictor of stroke outcome in all the modalities of thrombolysis. Thrombolysis in acute ischemic stroke evolved ...
Arboix Adrià - - 2009
BACKGROUND: Little is known about clinical features and prognosis of patients with ischaemic stroke caused by infarction in the territory of the anterior cerebral artery (ACA). This single centre, retrospective study was conducted with the following objectives: a) to describe the clinical characteristics and short-term outcome of stroke patients with ...
Boffetta Paolo - - 2009
To assess whether people who use smokeless tobacco products are at increased risk of myocardial infarction and stroke. Meta-analysis of observational studies from Sweden and the United States. Electronic databases and reference lists. Quantitative estimates of the association between use of smokeless tobacco products and risk of myocardial infarction and ...
Syrjälä Anna-Maija H - - 2009
In most previous studies the association between number of teeth and cardiovascular diseases has been found to be stronger among younger age groups than in older age groups, which indicates that age may modify the association between number of teeth and cardiovascular diseases. We investigated the association between tooth loss ...
Adams Harold P HP Jr Department of Neurology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, - - 2009
Atherosclerotic vascular disease is the leading cause of ischemic stroke, resulting in occlusive or severely stenotic lesions of major intracranial or extracranial arteries and narrowing of small penetrating arteries of the brain. Atherosclerosis of the coronary arteries (ie, coronary artery disease) is an indirect cause of cardioembolic stroke secondary to ...
Turhan Nur N Baskent University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey. - - 2009
Most cardiovascular abnormalities are associated not only with increased risk of certain ischemic stroke subtypes but also with markedly greater disability in stroke patients. We aimed to investigate the associations between age, comorbidity, cardiovascular problems, site and size of ischemic lesions and functional outcome in inpatient first-ever ischemic stroke patients. ...
Campbell Norm R C - - 2009
The Canadian Hypertension Education Program, an extensive professional education program to improve the management of hypertension, was started in 1999. There were very large increases in diagnosis and treatment of hypertension in the first 4 years after initiation of the program. The purpose of this study was to examine the ...
Yamagishi Kazumasa - - 2009
OBJECTIVE: We sought to clarify the validity of self-reported stroke and myocardial infarction (MI) among Japanese population, because information on the validity, particularly on the sensitivity, of self-reported cardiovascular disease is limited and may differ among countries. STUDY DESIGN AND SETTING: Using the 10-year follow-up questionnaire and a stroke and ...
Porto Fábio H G - - 2009
BACKGROUND: Hemimedullary syndrome is very rare and combines the clinical features of lateral and medial medullary infarctions. In patients with hemimedullary syndrome, the presence of ipsilateral, rather than contralateral hemiplegia, is rare. OBJECTIVE: To describe a patient with an infarction in the right hemimedulla with an ipsilateral motor deficit due ...
Jeffree Rosalind L - - 2009
Patients with carotid artery occlusion and haemodynamic insufficiency have a high risk of stroke. Cerebral revascularization surgery improves cerebral blood flow, but it remains unclear whether this reduces the risk of stroke. This study assesses the long-term outcome of patients undergoing superficial temporal artery to middle cerebral artery (STA-MCA) bypass ...
Dziedzic T - - 2009
BACKGROUND: Acute hyperglycemia predicts increased mortality after stroke. The aim of our study was to determine if acute stroke patients with hyperglycemia suffer from increased rate of in-hospital adverse events which could influence survival such as pneumonia, heart failure and myocardial infarction. METHODS: In a retrospective study with prospective follow-up, ...
Calvin Andrew D - - 2009
Obstructive sleep apnea (OSA) is common among patients with cardiovascular disease; however, the association between OSA and risk of cardiovascular events is not clear. Valham and colleagues studied the effect of OSA on incident stroke, acute myocardial infarction, and death in patients with angina pectoris who were referred for coronary ...
Jung Keun-Hwa - - 2009
Our recent work suggested that early infusion of nitrite might represent a novel therapeutic approach for acute ischemic stroke. In this study, we sought to examine the therapeutic time window of nitrite in an experimental stroke model, and to develop combined strategies for augmenting its protective effects. Nitrite was infused ...
Cheng Mu-Hua - - 2009
BACKGROUND AND AIM: Ventricular stroke work (SW) is one of the best indices to evaluate ventricular function, however, the SW monitoring mainly depends on the invasive method with the artery catheter. In this paper, our aim is to develop a new semi-quantitative non-invasive method for evaluating ventricular SW. METHODS: The ...
Zsuga Judit - - 2008
AIM: Ischemic preconditioning has been well established in healthy human hearts, but limited information is available about its occurrence or its integrity in the brain. The aim of the present study was therefore to investigate whether a prior cerebral ischemic episode (stroke or transient ischemic attack [TIA]) is able to ...
Shin Hwa Kyoung - - 2008
BACKGROUND: Rho and Rho-associated kinase (ROCK) play pivotal roles in pathogenesis of vascular diseases including stroke. ROCK is expressed in all cell types relevant to stroke, and regulates a range of physiological processes. OBJECTIVE: To provide an overview of ROCK as an experimental therapeutic target in cerebral ischemia, and the ...
Wahab Kolawole Wasiu - - 2008
OBJECTIVE: To determine the predictors of 30-day intra-hospital case fatality rate in patients with first-ever acute ischaemic stroke, attending a tertiary care hospital in Western Nigeria. STUDY DESIGN: A cross-sectional observational study. PLACE AND DURATION OF STUDY: This study was conducted at the Lagos University Teaching Hospital, Lagos, Nigeria between ...
Hart Robert G - - 2008
Six studies from 2006-2008 that have influenced clinical management of stroke and threatened stroke are presented. The ABCD2 score effectively stratifies the short-term risk of stroke following transient ischemic attack into those with a high (12%), moderate (6%), and low (1%) 7-day stroke risk. High-dose atorvastatin reduces recurrent stroke in ...
Plaikner Michaela - - 2009
BACKGROUND: Soluble CD40 ligand (sCD40L) has been proposed as a new risk marker for cardiovascular diseases; however, its possible role as a diagnostic marker in the emergency department (ED) has not yet been investigated. METHODS: We investigated sCD40L for the diagnosis of acute myocardial infarction or ischemic stroke in 1089 ...
Nguyen T H - - 2008
We report a case of intravenous thrombolysis in a patient with early recurrent stroke. A 62-year-old man recovered nearly completely after a lacunar infarct of the left putamen. He suffered stroke recurrence 7 days later due to a new infarct in the left internal capsule. Intravenous alteplase 0.9 mg/kg was ...
Kwon Hyung-Min - - 2009
BACKGROUND: Basilar artery (BA) dolichoectasia (dilatative arteriopathy) (BAD) causes arterial elongation and enlargement with subsequent hemodynamic changes leading to thrombosis, microembolization and brainstem compression. Little is known about the association between BAD and the pattern of pontine infarct in patients without BA stenosis. METHODS: We studied patients with isolated pontine ...
Tang C W - - 2009
A 55-year-old man developed ischemic stroke after three episodes of transient dysarthria and left hemiplegia, a typical manifestation of capsular warning syndrome. Magnetic resonance imaging of the brain showed bilateral basal ganglionic infarction. The patient had no significant risk of stroke. However, the systemic manifestations, an elevated titer of perinuclear ...
Bang O Y OY Department of Neurology, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, South Korea. - - 2008
In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanalization therapy for acute ischemic stroke. We analyzed ...
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