Search Results
Results 251 - 300 of 1386
< 1 2 3 4 5 6 7 8 9 10 11 >
Bove Christina M - - 2006
The Investigational Review Board approved the protocol, and all patients provided signed informed consent. The protocol was compliant with HIPAA. The purpose of the study was to prospectively test the hypothesis that addition of low-dose dobutamine and quantification of inotropic reserve in segments with 1%-50% infarct transmurality (IT) would improve ...
Jagathesan Rohan R MRC Clinical Sciences Centre and National Heart and Lung Institute, Imperial College, London, - - 2006
A meta-analysis of 13 randomized placebo-controlled trials demonstrated a benefit for dipyridamole therapy, particularly with longer duration of treatment. Although the mechanism of this effect is not well understood, dipyridamole increases endogenous tissue adenosine, which may have a beneficial effect on myocardial perfusion. Therefore, we measured the effects of dipyridamole ...
Chatzizisis Yiannis S - - 2007
On the basis of pathological, angiographical, intravascular ultrasound and computed tomography data coronary atherosclerosis appears to be more prevalent in the left coronary arterial system compared to the right. However, the pathophysiological mechanisms implicated in this discrepancy largely remain uncertain. The hemodynamic or anatomical differences between the right and left ...
Kobal Sergio L - - 2006
The feasibility and diagnostic accuracy of transesophageal pacing stress echocardiography for detection of inducible myocardial ischemia were evaluated in 161 patients 80 years of age or older (mean 84 +/- 3.9, range 80-97). The pacing time was 5.5 +/- 2.5 minutes with a total test time of 37 +/- 7 ...
Feringa Harm H H - - 2006
OBJECTIVE: This study was undertaken to determine to what extent hemodynamic responses to dobutamine infusion between patients using concomitant beta1-selective or nonselective beta-blockers differ and whether this difference affects the long-term prognostic value of dobutamine stress echocardiography with respect to cardiac events. DESIGN: Single center, observational study. METHODS: A total ...
Bernhardt P - - 2006
BACKGROUND: Evaluating myocardial function, assessing ischemic myocardial areas and detecting myocardial viability are necessary diagnostic information for guiding further therapy in patients with angina. The aim of this study was to show feasibility and safety of a compiled contrast- enhanced magnetic resonance imaging (ceMRI) protocol providing the above mentioned diagnostic ...
Peix Amalia - - 2006
BACKGROUND: Coronary artery disease is frequent in postmenopausal women. Silent myocardial ischemia has been induced with mental stress testing. METHODS AND RESULTS: To evaluate whether mental stress can induce ischemia in women with typical angina and normal coronary angiography, postmenopausal patients (n = 16) were studied. Each underwent technetium 99m ...
Bangalore Sripal - - 2006
BACKGROUND: Patients with prior myocardial infarction (MI) are at increased risk of subsequent cardiac events (MI or cardiac death). The incremental prognostic value and warranty time of a normal stress echocardiogram in this high-risk population is not well defined. METHODS: We evaluated 251 consecutive patients (62 +/- 11 years; 64% ...
Gentile Francesco - - 2006
The development of new echocardiographic contrast agents that can be injected intravenously and can opacify left-sided cardiac chambers has offered a contribution in the field of stress-echocardiography for two main reasons: (1) the improvement of visualization of the endocardial border and thus facilitating recognition of wall motion abnormalities during pharmacological ...
Makaryus Amgad N - - 2006
Left ventricular outflow tract (LVOT) obstruction occurring during dobutamine stress echocardiography (DSE) occurs in approximately 15-20% of patients undergoing DSE. The clinical significance and mechanism of LVOT obstruction has been debated, but is now generally felt to result from the pharmacological effects of dobutamine in increasing inotropy and causing peripheral ...
Varga Albert - - 2006
The safety of any diagnostic test is a major issue in deciding its practicability and cost-effectiveness. The aim of this study was to evaluate the safety of various stress echocardiographic modalities in the "real world." From February 1998 to January 2004, a simple written questionnaire was distributed to echocardiography laboratories ...
Fragasso Gabriele - - 2006
BACKGROUND: Previous studies provide evidence for a significant reduction of coronary flow reserve after ingestion of meals of different compositions. A possible role of hyperinsulinemia and increased free fatty acid levels, which are deleterious during acute myocardial ischemia and reperfusion, has been hypothesized. We assessed in patients with stable coronary ...
Zhu Xiang-Yang - - 2006
OBJECTIVE: We tested the hypothesis that in early hypertension (HT), increased oxidative stress leads to myocardial microvascular remodeling. METHODS AND RESULTS: Pigs were studied after a 12-week observation: normal (n=8), untreated renovascular HT (n=8), or HT+chronic antioxidant supplementation (HT+A, n=6). Left ventricular muscle mass (LVMM) and myocardial blood flow (MBF) ...
Vitarelli Antonio - - 2006
BACKGROUND: The purpose of the present study was to assess the accuracy of quantitative segmental analysis by strain rate imaging (SRI) technique during dobutamine test for detecting myocardial recovery after revascularization in patients with chronic ischemic regional left ventricular (LV) dysfunction and compare results with those of 2-dimensional echocardiography (2D) ...
Jagathesan Rohan R MRC Clinical Sciences Centre, Imperial College, London, United - - 2006
Mechanistic differences between pharmacologic stressors may offer different clinical benefits. Therefore the effects of dobutamine and adenosine on absolute myocardial blood flow (MBF) and coronary flow reserve (CFR) were compared. We divided 36 patients (mean age, 61 +/- 8 years) with coronary artery disease into 2 groups based on stenosis ...
Moir S - - 2006
OBJECTIVE: To use quantitative myocardial contrast echocardiography (MCE) and strain rate imaging (SRI) to assess the role of microvascular disease in subclinical diabetic cardiomyopathy. METHODS: Stress MCE and SRI were performed in 48 patients (22 with type II diabetes mellitus (DM) and 26 controls), all with normal left ventricular systolic ...
Rakhit D J - - 2006
OBJECTIVE: To examine whether aggressive risk factor modification in chronic kidney disease (CKD) can limit the development of new ischaemia or reduce cardiac events. METHODS: Patients with CKD were randomly assigned to either an aggressive risk factor modification strategy (targeted treatment of hypertension, dyslipidaemia, homocysteine, haemoglobin and phosphate) or standard ...
Marwick Thomas H - - 2006
Strain and strain rate (SR) are measures of deformation that are basic descriptors of both the nature and the function of cardiac tissue. These properties may now be measured using either Doppler or two-dimensional ultrasound techniques. Although these measurements are feasible in routine clinical echocardiography, their acquisition and analysis nonetheless ...
Owen P J D - - 2006
CONTEXT: Subclinical hypothyroidism (SCH) is associated with increased risk of cardiac disease; its impact on arterial function is less clear. OBJECTIVE: The objective of the study was the assessment of arterial and cardiac function. DESIGN: The study was a 6-month controlled observational study using pulse wave analysis and tissue Doppler ...
Kasliwal Ravi R - - 2006
BACKGROUND: Coronary revascularization is known to improve left ventricular ejection function (LVEF) in patients with severe left ventricular systolic dysfunction if there is myocardial viability and contractile reserve is >40% as determined by low-dose dobutamine echocardiography (LDDE). We tried to assess effect of coronary revascularization on left ventricular systolic function ...
Alsaileek Ahmed A - - 2006
OBJECTIVES: Our objective was to evaluate whether normal left atrial volume index (LAVI) is a predictor of a normal stress echocardiogram and thus a predictor of low ischemic risk. BACKGROUND: Left atrial enlargement is closely related to the chronicity and intensity of the burden of increased ventricular filling pressure. Typically ...
Cheetham Andrew M - - 2006
OBJECTIVES: To investigate whether a significant number of normal 1-day stress-rest 99mTc-tetrofosmin myocardial perfusion scintigraphy (MPS) studies can be identified from the low-dose stress acquisition alone, and whether technical staff can find such studies reliably. METHODS: The supervising consultant and four technologists independently graded the stress acquisitions from 200 consecutive ...
Montisci R - - 2006
OBJECTIVE: To test whether preserved coronary flow reserve (CFR) two days after reperfused acute myocardial infarction (AMI) is associated with less microvascular dysfunction (" no-reflow" phenomenon) and is predictive of myocardial viability. DESIGN: 24 patients with anterior AMI underwent CFR assessment in the left anterior descending coronary artery (LAD) with ...
Otasevic P - - 2006
To compare head to head the indices of left ventricular contractile reserve assessed by high-dose dobutamine in the five-year prognosis of patients with idiopathic dilated cardiomyopathy. Prospective study in a tertiary care centre. 63 consecutive patients with idiopathic dilated cardiomyopathy. High-dose dobutamine stress echocardiography was performed in progressive stages lasting ...
Navare Sachin M - - 2006
OBJECTIVES: The purpose of this research was to evaluate the significance of heart rate response to dobutamine and the assessment of left ventricular (LV) function during risk stratification of patients undergoing dobutamine stress myocardial perfusion imaging (DSMPI). BACKGROUND: Dobutamine stress myocardial perfusion imaging has been shown to effectively risk stratify ...
Min James K - - 2006
BACKGROUND: Recent evidence suggests a strong link between erectile dysfunction (ED) and atherosclerotic vascular disease. Stress myocardial perfusion single-photon emission computed tomography (MPS) is a widely used noninvasive imaging modality that allows diagnosis of coronary heart disease and stratification of cardiovascular risk. We sought to determine the relationship between ED ...
Grawe H - - 2006
Stress cardiomyopathy is a novel clinical syndrome affecting predominantly elderly female patients. It is characterized by severe reversible left ventricular dysfunction demonstrating a peculiar pattern of extensive apical wall motion abnormality known as "apical ballooning". The syndrome is typically precipitated by acute severe emotional, psychological or physical stress. It mimics ...
Bangalore Sripal - - 2006
The role of heart rate (HR) reserve (HRR) in the risk stratification of patients who undergo dobutamine stress echocardiography is not well defined. This study evaluated 1,323 patients (mean age 63 +/- 13 years, 47% men) who underwent dobutamine stress echocardiography. Abnormal stress echocardiographic results were defined as those with ...
Khanna Deepak - - 2006
A growing body of clinical and experimental literature supports a strong association between emotional stress and adverse outcomes from CVD. Effects of emotional stress on coronary blood flow and cardiac arrhythmias provide only a partial explanation. A direct impact of emotional stress on myocardial function has recently received attention as ...
Vande Geest Jonathan P - - 2006
The rupture risk of abdominal aortic aneurysms (AAAs) is thought to be associated with increased levels of wall stress. Finite element analysis (FEA) allows the prediction of wall stresses in a patient-specific, non-invasive manner. We have recently shown that it is important to include the intra-luminal thrombus (ILT), present in ...
Nighoghossian Norbert - - 2006
BACKGROUND: Several testing options are available to detect asymptomatic coronary artery disease (CAD). Dobutamine stress echocardiography (DSE) has been reported to increase the sensitivity and specificity of stress testing to detect CAD. Most studies concerned patients with known or suspected CAD who have a high pretest probability of disease. We ...
Haluska B A - - 2006
OBJECTIVE: To seek an association between total arterial compliance (TAC) and the extent of ischaemia at stress echocardiography. DESIGN: Cohort study. SETTING: Regional cardiac centre. METHODS: 255 consecutive patients (147 men; mean (SD) age 58 (8)) presenting for stress echocardiography for clinical indications were studied. Wall motion score index (WMSI) ...
Rigo Fausto - - 2006
BACKGROUND: Vasodilator stress echocardiography allows imaging of left anterior descending (LAD) coronary flow reserve (CFR), which may provide additional prognostic information over regional wall motion. AIM: To assess the prognostic value of CFR in patients with known or suspected coronary artery disease (CAD) and negative stress echo. METHODS: We studied ...
Weidemann Frank - - 2006
Ongoing myocardial thickening after aortic valve closure (postsystolic thickening = epsilonPST) is an established marker for the presence of segmental ischemia. However, epsilonPST may also be present in late activated segments and can be induced by pharmacological interventions or left ventricular pressure overload. The aim of this study was to ...
Arpesella Giorgio - - 2006
The heart transplant is a treatment of the heart failure, which is not responding to medications, and its efficiency is already proved: unfortunately, organ donation is a limiting step of this life-saving procedure. To counteract heart donor shortage, we should screen aged potential donor hearts for initial cardiomyopathy and functionally ...
Smedema J P JP N1 City Medical Chambers, Goodwood, South - - 2006
A 54-year-old woman with occlusive disease of the distal abdominal aorta was referred for pre-operative risk assessment, and was diagnosed with severe impairment of the left ventricular function due to left main stem coronary artery stenosis. Low-dose dobutamine stress echocardiography did not demonstrate contractile reserve, while gadoliniumenhanced cardiac magnetic resonance ...
Roberts Elved B - - 2006
BACKGROUND: Simultaneous wall motion and myocardial perfusion analysis could offer advantages over either method alone. Diagnostic utility of combining these parameters during dobutamine stress echocardiography is evaluated in this study. METHODS: Myocardial contrast dobutamine stress echocardiography was performed on thirty-eight patients with single or double vessel coronary artery stenosis of ...
Lee Leong L Department of Cardiology, University of Nottingham, Queens Medical Centre, Nottingham, - - 2005
Chronic heart failure (CHF) is a major cause of morbidity and mortality that requires a novel approach to therapy. Perhexiline is an antianginal drug that augments glucose metabolism by blocking muscle mitochondrial free fatty acid uptake, thereby increasing metabolic efficiency. We assessed the effects of perhexiline treatment in CHF patients. ...
Price S - - 2006
BACKGROUND: The use of echocardiography in the critically ill presents specific challenges. However, information of direct relevance to clinical management can be obtained relating to abnormalities of structure and function and can be used to estimate pulmonary arterial and venous pressures. DISCUSSION: Investigation of the consequences of myocardial ischaemia, valvular ...
Ikonomidis Ignatios - - 2005
BACKGROUND: Interleukin-6 (IL-6) and macrophage colony stimulating factor plasma levels are elevated in acute coronary syndromes. IL-6 has an inherent negative inotropic action and, with tissue factor (TF), mediates the ischemia-reperfusion myocardial injury. We hypothesized that inducible ischemia leads to cytokine production, TF expression, and consequently persistent left ventricular dysfunction ...
Schinkel Arend F L - - 2006
Previous studies have shown a good outcome for patients who present with normal findings on stress myocardial perfusion imaging. Currently, the prognostic implications of a normal study in patients who have a history of coronary artery disease (CAD) are not clear. This study investigated the long-term prognosis after a normal ...
Mauro Víctor M - - 2005
BACKGROUND: The aim of early treatment of acute myocardial infarction (AMI) is to achieve the rapid reperfusion of the culprit artery, which correlates with improvement in ventricular function and survival. With the widespread use of thrombolytic agents or coronary angioplasty as reperfusion strategies for AMI, it is possible to reduce ...
Blatt Alex - - 2005
BACKGROUND: Recent studies suggest that myocardial administration of stem cells improves perfusion and function of ischemic myocardium. The present study evaluated the safety and efficacy of simple intracoronary administration of mononuclear autologous bone marrow (BM) cells in patients with ischemic cardiomyopathy without revascularization option. METHODS AND RESULTS: We enrolled 6 ...
Huang Lei - - 2005
In this study we sought to determine whether a calcium sensitizer, levosimendan, would have a more favorable effect on postresuscitation myocardial function and, consequently, postresuscitation survival than beta-adrenergic dobutamine. The extreme decrease in survival before hospital discharge of resuscitated victims is attributed, in part, to postresuscitation myocardial failure, and dobutamine ...
Pauliks Linda B - - 2005
BACKGROUND: Color tissue Doppler imaging permits noninvasive quantitation of regional wall motion. In experimental studies, a new marker, the slope of the isovolumic contraction wave, isovolumic acceleration (IVA) was more insensitive to ventricular loading conditions than myocardial velocities. This study compared the regional response IVA to dobutamine stress echocardiography to ...
Bacon Simon L - - 2006
Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radionuclide ventriculography during a multiple stress challenge. Plasma volume was assessed during rest ...
Bodí Vicente - - 2005
OBJECTIVES: We sought to evaluate the usefulness of a comprehensive assessment of four cardiovascular magnetic resonance imaging (CMR)-derived myocardial viability indexes in the setting of myocardial stunning. BACKGROUND: Cardiovascular magnetic resonance imaging allows the simultaneous assessment of several viability indexes. METHODS: We studied 40 patients with a first ST-segment elevation ...
Schimke Ingolf - - 2005
Patients with idiopathic dilated cardiomyopathy (IDC) were treated with selective immunoadsorption to remove anti-beta 1-adrenoreceptor autoantibodies (anti-beta1A-AB). After one year, the effect on cardiac performance and oxidative stress was tested. Extracorporeal immunoadsorption of the whole IgG class in IDC patients for the removal of anti-beta1A-AB reduced oxidative stress in parallel ...
Frommelt Peter C - - 2005
PURPOSE OF REVIEW: The past year was dominated by developments in echocardiographic assessment of myocardial function in children, and this paper reviews some of these major advancements in pediatric echocardiography as a guide to those interested in imaging of the pediatric heart and vascular system. RECENT FINDINGS: Characterization of myocardial ...
Elhendy Abdou - - 2005
This study assessed the incidence, clinical correlates, and prognostic significance of angina during dobutamine stress echocardiography (DSE) in patients who did not have inducible wall motion abnormalities. We studied 2,117 patients (61 +/- 13 years of age; 1,149 men) who underwent large-dose DSE and had no new or worsening wall ...
< 1 2 3 4 5 6 7 8 9 10 11 >