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Rosales Xiomara Q - - 2011
Limb girdle muscular dystrophies (LGMD) are inclusive of 7 autosomal dominant and 14 autosomal recessive disorders featuring progressive muscle weakness and atrophy. Studies of cardiac function have not yet been well-defined in deficiencies of dysferlin (LGMD2B) and fukutin related protein (LGMD2I). In this study of patients with these two forms ...
Ney Ludwig - - 2010
We report on a trauma victim without history of or risk factors for cardiac disease, who suffered coronary artery dissection caused by blunt chest injury (BCI). Myocardial ischaemia was detected by multislice computed tomography (MSCT) promptly after trauma centre admission and managed by immediate revascularisation. Thoracic trauma may cause myocardial ...
Xiang Fei - - 2010
AIMS: Long-term outcome of patients after myocardial infarction (MI) largely depends on the extent of post-infarct remodelling. To explore the molecular mechanism of remodelling, comparative proteomic analysis was undertaken to identify differential myocardial proteome profiles expressed in the border zone of the post-MI heart. METHODS AND RESULTS: Two-dimensional gel electrophoresis ...
Takanari Hiroki - - 2011
Bepridil is effective for conversion of atrial fibrillation to sinus rhythm and in the treatment of drug-refractory ventricular tachyarrhythmias. We investigated the effects of bepridil on electrophysiological properties and spiral-wave (SW) reentry in a 2-dimensional ventricular muscle layer of isolated rabbit hearts by optical mapping. Ventricular tachycardia (VT) induced in ...
Kayrak Mehmet - - 2010
Atrial remodeling is an important part of cardiac remodeling after acute myocardial infarction (AMI). The aim of this study was to evaluate the effect of spironolactone on atria in patients with preserved left ventricular (LV) functions after AMI by using two-dimensional and tissue Doppler imaging techniques (TDI). The study consisted ...
Freire Grace - - 2010
We report the use of the hybrid procedure (bilateral pulmonary artery banding, ductal stenting followed by balloon atrial septostomy) in the first week of life for the treatment of two neonates with large left ventricular fibromas resulting in univentricular physiology. At 6 months of age, second-stage palliation was accomplished and ...
Zeghichi-Hamri Sabrina - - 2010
Dietary n-3 polyunsaturated fatty acids (PUFA) reduce coronary heart disease (CHD) complications, such as chronic arrhythmia and sudden cardiac death. Improved myocardial resistance to ischemia-reperfusion injury results in smaller myocardial infarction, which is a major factor in the occurrence of CHD complications. We hypothesized that a specific dietary fatty acid ...
Blanton Robert M - - 2010
We report a patient who presented with new onset atrial fibrillation in the setting of inferior ST-segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with prompt conversion of the rhythm to ...
Fujisaki M - - 2010
Current fetal cardiac intervention for restrictive atrial septum is invasive and technically demanding. We investigated the feasibility of computer-assisted high-intensity focused ultrasound (HIFU) for cardiac intervention on the atrial septum of a beating heart. To create an interatrial communication in the beating heart of nine anesthetized rabbits, the heart was ...
Subban Vijayakumar - - 2011
A 71 year-old female presented with a large left aortic sinus to right atrial fistula causing severe congestive heart failure and atrial fibrillation. Successful percutaneous closure of the defect was achieved using a 20/18 duct occluder with dramatic improvement in symptoms.
DÄ…browska-Kugacka Alicja - - 2011
The aim of the study was to assess the relationship between P-wave duration on the surface electrocardiogram (ECG) and echocardiographic parameters of atrial electromechanical delay (EMD), as well as contraction synchrony during different atrial pacing modalities. In 57 patients with sinus node disease and prolonged sinus P-wave duration treated with ...
Matsuo Seiichiro - - 2012
Peri-mitral atrial flutter, which is a type of macroreentrant atrial tachycardia circulating around the mitral annulus, was terminated with the guidance of the high-density mapping catheter. A 72-year-old woman with atrial fibrillation and atrial tachycardia presented with symptoms of congestive heart failure. The recurrent peri-mitral atrial flutter following the initial ...
Fedorov Vadim V VV Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, - - 2010
We sought to confirm our hypothesis that the human sinoatrial node (SAN) is functionally insulated from the surrounding atrial myocardium except for several exit pathways that electrically bridge the nodal tissue and atrial myocardium. The site of origin and pattern of excitation within the human SAN has not been directly ...
Michowitz Yoav Y UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1679, - - 2011
Electrophysiological properties of the atrial endocardium compared to epicardium are not well understood. The purpose of this study was to compare the electrophysiological properties and vulnerability to arrhythmia induction from these regions. Transseptal endocardial and percutaneous epicardial mapping were performed in a porcine model (n = 7). Two opposing 4-mm ...
Bordachar Pierre - - 2011
PEA Recorded in the Atrium. Introduction: Preliminary studies have revealed a high correlation between peak endocardial acceleration (PEA) measured with a sensor embedded in a ventricular lead and human cardiac contractility. In this study we assessed (1) the contributions made by measurements of PEA1, an index of ventricular systolic contraction, from ...
Pakarinen Sami - - 2010
The main objective of this study was to characterize morphological differences between sinus and retrograde atrial waves. We collected intracardiac atrial signals through a DDDR pacemaker to characterize their morphologies and discriminate retrograde from sinus atrial waves off-line. Intracardiac unipolar and bipolar signals were collected at an 800-Hz sampling rate ...
Toyohara Keiko - - 2011
Ectopic atrial tachycardia (EAT) often resists medical therapy, making radiofrequency catheter ablation (RFCA) the preferred treatment. This study reviewed the records of 35 patients who underwent electrophysiologic studies (EPS) and 39 RFCA procedures for EAT during a 10-year period. Of the 35 patients, 10 (28%) presented with decreased ventricular function ...
Villamizar Nestor R NR Department of Surgery, Duke University Medical Center, Durham, NC 27713, USA. - - 2010
Achieving transmural tissue ablation might be necessary for successful treatment of atrial fibrillation. The purpose of this study was to evaluate the reproducibility of transmural left atrial ablation using a high-intensity focused ultrasound energy system in a calf model. Nine heparinized bovines underwent a beating-heart left atrial ablation with a ...
Platonov Pyotr G - - 2011
LAA Activity in Surface ECG. Introduction: Interatrial frequency gradient is used to guide catheter ablation of atrial fibrillation (AF). Lead V1 adequately reflects right atrial activity, but reliable tools for noninvasive estimation of right versus left fibrillatory frequency are lacking. In this study, patients with dissociated left and right atrial ...
Naqvi Tasneem Z - - 2010
The authors describe the case of a 79-year-old man with prior mitral valve repair and a maze procedure who developed recurrent atrial fibrillation, in whom transesophageal echocardiography revealed an accessory lobe of the left atrial appendage in sinus rhythm when the remaining body of the left atrial appendage was in ...
Suenari Kazuyoshi - - 2010
We report a case of focal atrial tachycardia (AT) originating from prior superior vena cava isolation line. The P-wave morphology in lead aVL during the AT differed from that during sinus rhythm although their foci were in close proximity to each other. We discuss the mechanism based on the activation ...
Okutucu Sercan - - 2011
Atrial septal aneurysm (ASA) is a saccular deformity located in the atrial septum. Atrial arrhythmias are common in patients with ASA. Atrial electromechanical delay (AEMD) can be used to evaluate development of atrial arrhythmias in various settings. The aim of the study was to investigate the relationship between ASA, cardiac ...
Khoo Chee W - - 2011
Left atrial enlargement is an important predictor of cardiovascular events such as atrial fibrillation, stroke, heart failure and mortality. A number of methods of left atrial size assessment by echocardiography have been reported, from the simple antero-posterior diameter in the parasternal long axis view to the more complex ellipsoid, area-length ...
Petit Christopher J - - 2010
Infants with hypoplastic left heart syndrome and intact or highly restrictive atrial septum require emergent therapy to relieve pulmonary congestion. Transcatheter stenting has become, in most large centers, the mainstay of therapy for relief of left atrial hypertension. Normally, this procedure is performed with the assistance of transesophageal echocardiographic guidance. ...
Sirak John - - 2010
PURPOSE: Comprehensive treatment of atrial fibrillation requires both compartmentalization of the posterior left atrium and connecting ablations to the mitral annulus to interrupt perimitral macro reentry and to isolate the arrhythmogenic left atrial substrate. We present a new procedure that compartmentalizes virtually all arrhythmogenic anatomy etiologic in atrial fibrillation, enabling ...
Toivonen Lauri - - 2010
This study assessed the cardiac electrophysiological and hemodynamic effects of an intravenous infusion of the combined ion channel blocker AZD1305. After successful ablation of atrial flutter, patients were randomized to receive placebo (n = 12) or AZD1305 (n = 38) in 4 ascending dose groups. Electrophysiological and hemodynamic measurements were ...
Liu Xingpeng - - 2010
OBJECTIVES: We sought to determine whether atrial tachycardia arising adjacent to the noncoronary aortic sinus (NCAS-AT) has distinctive atrial activation patterns in relation to targeted anatomic imaging. BACKGROUND: The knowledge of atrial activation patterns of the NCAS-AT and its anatomic basis is very limited. METHODS: Three-dimensional electroanatomic mapping was performed ...
Corradi Domenico - - 2011
Functional Anatomy of the Atria. The fact that some atrial and ventricular disorders (e.g., atrial fibrillation and heart failure) have a structural basis and cause atrial myocardial remodeling has led to increasing attention being paid to the atrial chambers. Furthermore, the rapid development of mapping and ablative procedures as a means ...
Blana Andreas - - 2010
Patients with long QT syndrome (LQTS) are at increased risk not only for ventricular arrhythmias but also for atrial pathology including atrial fibrillation (AF). Some patients with "lone" AF carry Na(+)-channel mutations. The purpose of this study was to determine the mechanisms underlying atrial pathology in LQTS. In mice with ...
Mah Douglas - - 2010
Acute success rates of accessory pathway ablation for Wolff-Parkinson-White (WPW) syndrome can exceed 95%, with rare failures attributed to anatomically complex epicardial connections. Right atrial appendage to right ventricle pathways have been reported, but their left-sided counterparts have only recently been described. The purpose of this study was to report ...
Wilhelm Matthias - - 2010
Recent data have suggested a relation among long-term endurance sport practice, left atrial remodeling, and atrial fibrillation. We investigated the influence of an increased vagal tone, represented by the early repolarization (ER) pattern, on diastolic function and left atrial size in professional soccer players. Fifty-four consecutive athletes underwent electrocardiography, echocardiography, ...
Cardinal René - - 2010
Chronotropic "vagal responses" elicited by high-frequency stimulation have been used to identify atrial targets for ablative treatment of atrial tachyarrhythmias (AT), whereas an anatomic approach consisting of extensive ablation of the ganglionated plexus areas has been proposed as an alternative. Therefore, there is a need for precise delineation of juxtacardiac ...
Rodés-Cabau Josep - - 2010
Percutaneous left atrial appendage (LAA) closure might reduce the cardioembolic risk in those patients with nonvalvular atrial fibrillation who are not candidates for warfarin therapy. This report presents the case of two patients with atrial fibrillation who had contraindications for warfarin therapy due to bleeding complications and a high cardioembolic ...
Schrickel Jan Wilko - - 2010
Desmin mutations in humans cause desmin-related cardiomyopathy, resulting in heart failure, atrial and ventricular arrhythmias, and sudden cardiac death. The intermediate filament desmin is strongly expressed in striated muscle cells and in Purkinje fibers of the ventricular conduction system. The aim of the present study was to characterize electrophysiological cardiac ...
Mivelaz Yvan - - 2010
OBJECTIVE: The objective of the study was to evaluate the reliability of the 2 most commonly used ultrasonographic approaches for monitoring fetal atrioventricular conduction time (AVCT): (1) superior vena cava/ascending aorta (SVC/AA), and (2) left ventricular inflow/outflow tract (LVI/O) Doppler recordings. STUDY DESIGN: Echographic studies from fetuses followed up for ...
De Bruaene Alexander Van - - 2011
Atrial fibrillation and flutter remain an important cause of morbidity in adults with atrial septal defect (ASD). This study aimed at investigating predictors for late (≥1month after repair) atrial arrhythmia. Patients who underwent ASD closure after the age of 18years, were selected through the databases of three medical centres in ...
Chen Songwen - - 2010
Dual-loop macro-reentry atrial flutter (AFL) is an atypical AFL, which has two loops of the reentry circuit usually localized within single atrium. In this case report, we present a double-loop bi-atrial flutter during atrial fibrillation ablation, in which the two reentry circuit loops were located around the inferior vena cava ...
Dautova Yana - - 2010
Loss- and gain-of-function cardiac Na(+) channel (SCN5A) mutations are associated with the Brugada and long QT type 3 syndromes (LQT3), respectively. Both result in ventricular arrhythmias, but have differing atrial effects. We have recently reported decreased incidences of atrial arrhythmias in a murine Scn5a+/Delta cardiac system used to model LQT3. ...
Zhang Yanmin - - 2011
The experiments explored for atrial arrhythmogenesis and its possible physiological background in recently developed hetero-(RyR2(+/S)) and homozygotic (RyR2(S/S)) RyR2-P2328S murine models for catecholaminergic polymorphic ventricular tachycardia (VT) for the first time. They complement previous clinical and experimental reports describing increased ventricular arrhythmic tendencies associated with physical activity, stress, or catecholamine ...
Roth Peter - - 2010
Ligation or amputation of the left atrial appendage is indicated in several surgical procedures but has been shown ineffective in many cases, depending on the method used. The only 100% effective means of excluding the left atrial appendage from the circulation is by complete resection. Complicating complete resection or amputation ...
Lanjewar D N - - 2010
Cardiac function has long been known to be altered in patients with thyrotoxicosis and atrial fibrillation occurs in patients with hyperthyroidism. In addition to its disabling symptoms, atrial fibrillation is a strong risk factor for systemic embolism, especially with regard to cerebral circulation. A right atrial appendage thrombus formation in ...
Patel Vickas V VV Penn Cardiovascular Institute and Division of Cardiovascular Medicine, 905 BRB II/III, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. - - 2010
Atrial fibrillation is the most common clinical cardiac arrhythmia. It is often initiated by ectopic beats arising from the pulmonary veins and atria. While pulmonary vein myocytes most likely contribute to atrial ectopic beats initiating atrial fibrillation, emerging evidence suggests the existence of other cell populations that may also contribute ...
Gunes Y - - 2010
This article describes four essential components (hemodynamic, bioelectrical, hormonal and metabolic) of atrial function. And then discusses the traditional and more recent echocardiographic measures that have been employed to evaluate atrial function. Conventional parameters include the study of the various phases of atrial activity using atrial volume measurements, the peak ...
Pokushalov Evgeny - - 2010
This report describes a case of left atrial appendectomy after a failed endocardial catheter ablation of a continuous drug-refractory left atrial appendage (LAA) tachycardia in a 9-year-old boy. Electrophysiologic study showed atrial tachycardia (AT) originating in the LAA. Numerous radiofrequency applications with an irrigated-tip catheter were ineffective. During surgery, direct ...
Zhu Hui - - 2010
Ultrasonic tissue characterization has the potential to provide quantitative information which could characterize the functional and structural state of cardiac muscle. In this study we aimed to determine whether the integrated backscatter is measurable and quantifiable in left atrial posterior walls in patients with chronic atrial fibrillation (AF) and can ...
Dabrowska-Kugacka Alicja - - 2010
It has been proposed that multisite atrial pacing (MSAp) restores atrial electrical activation and prevents atrial fibrillation recurrence; however, single-site Bachmann's bundle pacing (BBp) has also been reported as providing effective atrial resynchronization. Coronary sinus pacing (CSp) leads to reversed impulse propagation within the atria. Acute echocardiographic examination was performed ...
Belus Alexandra - - 2010
RATIONALE: Chronic atrial fibrillation (cAF) is associated with atrial contractile dysfunction. Sarcomere remodeling may contribute to this contractile disorder. OBJECTIVE: Here, we use single atrial myofibrils and fast solution switching techniques to directly investigate the impact of cAF on myofilament mechanical function eliminating changes induced by the arrhythmia in atrial ...
Wang Jun J Institute of Biosciences and Technology, Texas A&M System Health Science Center, Houston, TX 77030, - - 2010
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, often coexists with the related arrhythmia atrial flutter (AFL). Limitations in effectiveness and safety of current therapies make an understanding of the molecular mechanism underlying AF more urgent. Genome-wide association studies implicated a region of human chromosome 4q25 in familial AF ...
Dickerson Jennifer A - - 2010
Atrial arrhythmias can occasionally be associated with atrial structural abnormalities that may require sophisticated diagnostic imaging for management. Lipomatous hypertrophy of the intraatrial septum is generally considered a benign fatty infiltrative process usually limited to the atrial septum. We present a rare case of lipomatous hypertrophy of the intraatrial septum ...
Toh Norihisa - - 2010
Identifying patients at high risk for the occurrence of atrial fibrillation is one means by which subsequent thromboembolic complications may be prevented. Left atrial enlargement is associated with progression of atrial remodeling, which is a substrate for atrial fibrillation, but impaired atrial pump function is also another aspect of the ...
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