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Andreou Ioannis I The Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
Coronary atherosclerosis progresses both as slow, gradual enlargement of focal plaque and also as a more dynamic process with periodic abrupt changes in plaque geometry, size, and morphology. Systemic vasculoprotective therapies such as statins, angiotensin-converting enzyme inhibitors, and antiplatelet agents are the cornerstone of prevention of plaque rupture and new ...
Kawai Hideki H Department of Cardiology, Fujita Health - - 2014
Background:The additive value of plaque characteristics determined by computed tomography angiography (CTA) in patients undergoing invasive coronary angiography (ICA) has not been established.Methods and Results:We studied 676 patients undergoing ICA and CTA within 3 months. The luminal diameter narrowing based on ICA and the presence of high risk plaque (HRP) based on ...
Puri Rishi R Discipline of Medicine, University of Adelaide, Adelaide, SA, - - 2014
Little is known of the relationship between coronary atheroma composition and corresponding endothelial dysfunction. We tested the hypothesis that segmental epicardial vasoreactivity relates to atheroma composition in patients with non-ST segment elevation myocardial infarction (NSTEMI) in vivo. In 23 NSTEMI patients referred for coronary angiography, a non-culprit vessel underwent intracoronary ...
Kawada Sanami S Department of Neurology, Okayama Kyokuto Hospital, Okayama. Electronic address: - - 2014
Multidetector computed tomography angiography (MDCTA) is useful to inspect cardiovascular pathologic changes with minimal invasiveness. Here we evaluated the usefulness of MDCTA to determine the cause of acute multiple brain infarction (AMBI). AMBI was defined as multiple recent infarcts demonstrated on diffusion-weighted imaging. A new infarction within 2 weeks from ...
Nakazato Ryo R Cardiovascular Center, St. Luke's International Hospital, Tokyo, - - 2014
Adverse plaque characteristics (APCs) by coronary computed tomography (CT) angiography (CTA) are associated with myocardial ischaemia and future acute coronary syndromes. The overall objective was to determine whether APCs on non-invasive CTA are associated with vulnerable plaque features by invasive optical coherence tomography (OCT). Sixty-eight coronary plaques in 45 patients ...
Xie Shuang-Lun SL Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, - - 2014
Circulating interleukin-18 (IL-18) is thought to promote atherosclerosis and cardiovascular complications such as plaque rupture. Atherosclerosis is also characterized by smooth muscle cell migration, a consequence of extracellular matrix (ECM) degradation regulated by metalloproteinases (MMPs). Because extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to promote plaque instability by inducing ...
Cheng Jin M JM Erasmus MC, Department of Cardiology , Rotterdam , the Netherlands - - 2014
Abstract Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation ...
Rudd Nima - - 2014
The incidence of perioperative myocardial infarction (PMI) globally is known to be around 2 to 3% and can prolong hospitalization, increased morbidity and mortality. Little is known about the pathophysiology and risk factors for PMI. We investigate the presence of elevated novel cardiac markers and preoperative coronary artery plaque through ...
Celik Omer O Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Training Hospital, Istanbul, - - 2014
Elevated gamma-glutamyl transferase (GGT) levels have been demonstrated to be associated with poor prognoses in patients with coronary artery disease. Coronary computed tomography angiography (CCTA) is a noninvasive imaging modality that may differentiate the structure of coronary plaques. Elevated plaque burdens and noncalcified plaques, detected by CCTA, are important predictors ...
Nakamura Daisuke D Division of Cardiology, Osaka Rosai Hospital, 1179-3, Nagasone-cho, Sakai, Osaka, 591-8025, - - 2014
A 70-year-old man with chest pain underwent coronary intervention for acute myocardial infarction. We immediately performed coronary thrombectomy with aspiration catheter and collected solid material as a result. After aspiration, we achieved thrombolysis in myocardial infarction trial (TIMI)-flow grade 3 without stenosis. Transesophageal echocardiography showed no intracardiac thrombus but pronounced ...
Galon Micheli Zanotti MZ Heart Institute - InCor, São Paulo University Medical School, São Paulo, - - 2014
Background: While the current methodology for determining fibrous cap (FC) thickness of lipid plaques is based on manual measurements of arbitrary points, which could lead to high variability and decreased accuracy, it ignores the three-dimensional (3-D) morphology of coronary artery disease. Objective: To compare, utilizing optical coherence tomography (OCT) assessments, ...
Cheng Jin M JM Department of Cardiology, Erasmus MC, Rotterdam, The - - 2014
The relation between C-reactive protein (CRP) and coronary atherosclerosis is not fully understood. This study aims to investigate the associations among high-sensitivity CRP, coronary plaque burden, and the presence of high-risk coronary lesions as measured by intravascular ultrasound (IVUS) and 1-year cardiovascular outcome. Between 2008 and 2011, grayscale and virtual ...
Brunetti Natale Daniele ND Cardiology Department, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy. Electronic address: - - 2014
To compare inflammatory response accompanying acute coronary syndrome (ACS) with that following coronary plaque rupture caused by coronary angioplasty (PCI). Twenty-seven consecutive subjects with either ACS or treated with PCI in the subacute phase of ACS underwent serial evaluation of circulating interleukin (IL)-2, IL-8, IL-10, interferon (IFN)-γ and tumor-necrosis-factor (TNF)-α ...
Murray Scott W SW 1 Institute for Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK ; 2 Department of Critical Care Research, University of Liverpool, Liverpool, - - 2014
Post-mortem pathological studies have shown that a "vulnerable" plaque is the dominant patho-physiological mechanism responsible for acute coronary syndromes (ACS). One way to improve our understanding of these plaques in vivo is by using histological "surrogates" created by intravascular ultrasound derived virtual histology (IVUS-VH). Our aim in this analysis was ...
Lee Jung-Ju JJ Department of Neurology, Eulji General Hospital, Eulji University College of Medicine, Seoul, - - 2014
Focal motor status epilepticus (FMSE) is often associated non-ketotic hyperglycemia (NKH). There are no previous reports describing FMSE with NKH that was accompanied by an acute cerebral infarction and its long term follow-up result. We describe the case of a patient having focal motor status epilepticus (FMSE) associated with non-ketotic ...
Kim Hidong H Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, - - 2014
Cholesterol embolization syndrome (CES) is a complication sometimes occurring after invasive endovascular procedures. CES is characterized by release of cholesterol crystals and particles from atheromatous plaques, which can occlude distal vessels and induce an inflammatory response, resulting in end-organ damage. We report the case of a 66-year-old man who presented ...
Moseley Brian D BD Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: - - 2014
It has previously been suggested that abnormalities in cardiac repolarization (QTc lengthening and shortening) are more likely to accompany seizures with hypoxemia and may be involved in sudden unexpected death in epilepsy (SUDEP). Accordingly, we evaluated for associations between peri-ictal QTc changes and hypoxemia. We performed a reanalysis of cardiac ...
Eggleston Katherine S KS Cyberonics, Inc., Houston, TX 77058, United States. Electronic address: - - 2014
Epileptic seizures can lead to changes in autonomic function affecting the sympathetic, parasympathetic, and enteric nervous systems. Changes in cardiac signals are potential biomarkers that may provide an extra-cerebral indicator of ictal onset in some patients. Heart rate can be measured easily when compared to other biomarkers that are commonly ...
Powell Kim L KL Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, - - 2014
Evidence from animal and human studies indicates that epilepsy can affect cardiac function, although the molecular basis of this remains poorly understood. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate pacemaker activity and modulate cellular excitability in the brain and heart, with altered expression and function associated with epilepsy and cardiomyopathies. Whether ...
Izadi Morteza M Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR - - 2014
Coronary artery disease (CAD) is the most common cause of death worldwide and many studies have been performed on reduction of its prevalence. This case control study was designed to investigate the presence of Cytomegaloviruses, Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of cadaveric coronary endothelium of patients with ...
Gardezi Skm S Specialty Registrar Cardiology, Worthing Hospital, - - 2014
The relationship between seizure activity and arrhythmias is not well established. Sinus tachycardia is commonly seen post seizure. Bradyarrythmias leading to seizure activity is rarely reported in the literature thus far. A 62-year-old lady presented with nocturnal seizures and was subsequently started on oral anti-convulsant with no relief of her ...
Sun Zhonghua Z 0000-0002-7538-4761 Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, WA 6845, - - 2014
Coronary computed tomography angiography (CCTA) has been recently evaluated for its ability to assess coronary plaque characteristics, including plaque composition. Identification of the relationship between plaque composition by CCTA and patient clinical presentations may provide insight into the pathophysiology of coronary artery plaque, thus assisting identification of vulnerable plaques which ...
Nakanishi Rine R 0000-0002-4237-3927 Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA 90502, - - 2014
For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks. CCTA can provide more information incorporating the presence, extent, and severity of CAD; coronary plaque burden; and characteristics that highly correlate ...
Isabel Clothilde C Université Paris Descartes, Service de Neurologie, Inserm U894, Paris, - - 2014
Watershed infarcts (WSI) are thought to result from hemodynamic mechanism, but studies have suggested that microemboli from unstable carotid plaques may distribute preferentially in watershed areas, i.e., between two cerebral arterial territories. Intraplaque haemorrhage (IPH) is an emerging marker of plaque instability and microembolic activity. We assessed the association between ...
Serra E Silva Filho Wagner W Federal University of Piauí, Piauí, - - 2014
The immune and infectious alterations occurring in periodontitis have been shown to alter the development and severity of cardiovascular disease. One of these relationships is the translocation of oral bacteria to atheroma plaques, thereby promoting plaque development. Thus, the aim of this study was to assess, by 16s cloning and ...
Plank Fabian F Department of Radiology , Innsbruck Medical University , Innsbruck , - - 2014
To prospectively assess the value of coronary CT angiography (CTA) in asymptomatic patients with high 'a priori' risk of coronary artery disease (CAD). 711 consecutive asymptomatic patients (61.8 years; 40.1% female) with high 'a priori' risk of CAD were prospectively examined with a coronary calcium score (CCS) and CTA. Coronary arteries ...
Baratloo Alireza A Department of Emergency Medicine, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR - - 2013
A sudden loss of consciousness followed by abnormal movements can be ictal or syncopal in origin. Transient response by the brain to sudden decrease of blood flow may cause sudden loss of consciousness followed by abnormal movements that mimic seizure. Dysrhythmia is one of the important and critical reasons of ...
Read Morgayn I MI Department of Pharmacology and Toxicology, University of Otago School of Medical Sciences, Dunedin, New - - 2014
Status epilepticus has been increasingly associated with cardiac injury in both clinical and animal studies. Our group has previously shown that excitotoxic seizure induction results in the formation of ischaemic myocardial infarcts and loss of cardiac haemodynamic function. We hypothesised that attenuation of cardiac sympathetic/parasympathetic balance with a central presynaptic ...
Kibar Ayse Esin - - 2013
Impaired cardiac myocardial function may contribute to the risk for sudden unexpected death of a patient with epilepsy. This study aimed to investigate the effect of antiepilepsy drugs (AEDs) on cardiac function in pediatric epileptic patients using standard and tissue Doppler imaging (TDI) echocardiography. This hospital-based, prospective cross-sectional study investigated ...
Babarao Hanmantrao Darku - - 2013
We report an elderly man with chronic uncontrolled localization-related epilepsy on three AEDs, who developed in-hospital symptomatic bradyarrythmia due to junctional atrio-ventricular (AV) rhythm after an episode of generalized seizure during his hospital stay. On further evaluation, the cardiac enzymes were normal and 2D-echocardiogram showed mild left ventricular hypertrophy. Patient ...
Nagler Josef - - 2013
BACKGROUND: This observational study documented heart rate over the entire course of electrically induced seizures and aimed to evaluate the effects of stimulus electrode placement, patients' age, stimulus dose, and additional predictors. METHOD: In 119 consecutive patients with 64 right unilateral (RUL) and 55 bifrontal (BF) electroconvulsive treatments, heart rate ...
Demirtas-Tatlidede Asli - - 2013
Akinetic mutism is characterized by profound apathy and a lack of verbal and motor output for action, despite preserved alertness. The condition usually follows bilateral damage to the medial frontal subcortical circuits. We report a 59-year-old right-handed woman who was admitted to the neurology ward with sudden-onset akinetic mutism. Her ...
Amin Faisal Mohammad - - 2013
A 46-year-old male with juvenile myoclonic epilepsy was admitted to the neurological department for convulsive seizures just after lamotrigine was discontinued. On admission he was awake but had a right-sided hemiparesis with Babinski sign and ataxic finger-nose test on the left side. An MR scan showed a left-sided pontine infarction, ...
Jung Andrew K - - 2013
Developmental venous anomalies (DVA) are normally diminutive and incidental.(1,2) In this 33-year-old patient with epilepsy, the DVA is holohemispheric. Her epilepsy probably originates from the left side based on semiology; the EEG displayed left-sided slowing. Axial T1-weighted sequences show skull atrophy, ventricular widening, and satellite cavernous malformations with accumulation of ...
Prasad Rajniti - - 2013
Ischemic infarction in scorpion sting envenomation is rare and only few cases have been reported in adults. A 3-y-old child is reported who developed recurrent generalized tonic-clonic seizures 2 h after admission and hemiparesis on third day of admission following scorpion sting. Cranial tomography showed infarction in right and left frontoparietal ...
Surges Rainer - - 2013
Human and animal studies provided controversial data on asymmetric cortical representation of cardiac function, which may partially be due to different study designs and inter-individual variability. Here, we investigated whether seizure-related changes in heart rate (HR) and cardiac repolarization depend on the side of seizure-activity in people with mesial temporal ...
Wang Jianping - - 2013
Bithalamic infarctions initially presenting as a convulsive seizure are rarely reported and, to our best knowledge, have never been reported in China. Here, we present a patient with convulsive seizure at the onset of bilateral paramedian thalamic infarction. The diffusion-weighted imaging revealed that the infarct area is supplied by Percheron ...
Michowitz Yoav - - 2012
Introduction: The usefulness of unipolar electrograms (EGMs) has been reported in assessing lesion transmurality and conduction block along ablation lines. It is unknown whether unipolar and bipolar EGM characteristics predict exit block during pulmonary vein isolation (PVI) procedures. Methods and Results: Twenty patients (63 ± 7 years; 14 males [70%]) ...
Yang Jingchun - - 2012
α-Actinin2 (Actn2) is a predominant protein in the sarcomere Z disc whose mutation can lead to cardiomyopathy. However, the function of Actn2 in Z-disc assembly and cardiomyopathy in vertebrates remains elusive. We leveraged genetic tools in zebrafish embryos to elucidate the function of Actn2. We identified a single Actn2 homologue ...
Mazza Alberto - - 2012
Syncope following permanent pacemaker (PM) implantation is a nightmare for electrophysiologists. We describe a case of daily recurrent syncope in an 84-year-old man having a dual-chamber pacemaker implanted for complete atrio-ventricular block occurred 4 years before the admission to our department. He had a history of arterial hypertension, parossistic atrial ...
Tian Ying - - 2012
Emerging data in the field of cardiac development as well as repair and regeneration indicate a complex and important interplay between endocardial, epicardial, and myofibroblast populations that is critical for cardiomyocyte differentiation and postnatal function. For example, epicardial cells have been shown to generate cardiac myofibroblasts and may be one ...
Chalkias Athanasios - - 2012
Cardiac arrest is a leading cause of death that affects more than a million individuals worldwide every year. Despite the recent advancement in the field of cardiac arrest and resuscitation, the management and prognosis of post-cardiac arrest brain injury remain suboptimal. The pathophysiology of post-cardiac arrest brain injury involves a ...
Akashi Ryohei - - 2012
A 43-year-old man was admitted to our hospital presenting with seizures and syncope. He had a history of a cold with a fever of 39°C occurring three days earlier. Electrocardiography (ECG) showed complete atrioventricular block (AV block) with a maximum pause of 32 seconds, for which temporary pacing was performed. ...
Aldrovandi Annachiara - - 2012
To investigate the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major adverse cardiac events (MACEs) in patients with suspected or known coronary artery disease (CAD). Seven hundred and sixty-seven consecutive patients (496 men, age 62±11 y) with suspected or known heart disease referred to an outpatient clinic ...
Aceros H - - 2011
Regression of left ventricular hypertrophy by moxonidine, a centrally acting sympatholytic imidazoline compound, results from a sustained reduction of DNA synthesis and transient stimulation of DNA fragmentation. Because apoptosis of cardiomyocytes may lead to contractile dysfunction, we investigated in spontaneously hypertensive rats (SHR), time- and dose-dependent effects of in vivo ...
Charles R A - - 2011
Cardiac arrest occurring on board aeroplanes is rare, but remains a common cause of inflight incidents. This review examines some of the management problems unique to inflight cardiac arrests, and emphasises the use of cardiopulmonary resuscitation and automated external defibrillators.
Zito Concetta - - 2011
OBJECTIVE: We sought to characterize the left ventricular strains and rotational mechanics in the infarct-related and remote regions of dilated heart following an ST-elevation myocardial infarction (STEMI) to understand the adaptive changes in global left ventricular function that develop several months after percutaneous coronary revascularization. METHODS: Forty-six patients with STEMI ...
Zheng Liang-Rong - - 2011
BACKGROUND: Diabetic hearts are vulnerable to ischemia/reperfusion (I/R) injury. Pretreatment with exogenous calcitonin gene-related peptide (CGRP) exerts a cardioprotective effect against myocardial I/R injury. Our previous study found that the CGRP level was decreased in diabetic hearts. This study aimed to investigate whether up-regulation of CGRP could reduce I/R injury ...
Borlaug Barry A - - 2011
Routine cardiac catheterization provides data on left heart, right heart, systemic and pulmonary arterial pressures, vascular resistances, cardiac output, and ejection fraction. These data are often then applied as markers of cardiac preload, afterload, and global function, although each of these parameters reflects more complex interactions between the heart and ...
Sjøli Benthe - - 2011
The aim of the study was to compare the ability of global strain and left ventricular ejection fraction (LVEF) to predict outcome after acute myocardial infarction (AMI). Left ventricular (LV) function was measured using strain by Doppler and LVEF in 77 patients. Measurements were performed at admission and after 10 ...
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