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Results 351 - 400 of 523
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Sunamori M - - 1982
Myocardial protective effect of lidocaine hydrochloride on the ischemic myocardium was evaluated by serum (MB-CK) and cardiac function in 48 patients; 24 patients in control (C) and 24 patients in lidocaine-treated group (L), who underwent aorto-coronary bypass surgery. Lidocaine hydrochloride, 1 mg/min was administered by continuous drip infusion from initiation ...
Krause E G - - 1982
In anesthetized open-chest dogs, tachyarrhythmia (TA) was electrically induced by above-threshold stimuli via the right ventricle. During TA, a significant increase in the release of PGE and cAMP was observed in the canine coronary sinus blood (CSB). The efflux of cAMP corresponded with a concomitant increase in the left ventricular ...
Lloyd E A - - 1981
A new anti-arrhythmic agent, lorcainide, has been compared with lignocaine in patients with acute myocardial infarction. Lorcainide has been shown to be as effective as lignocaine in suppressing ventricular ectopy. Lorcainide is unusually free of side-effects and has the great advantage over lignocaine of being effective when given orally.
Horwitz R I - - 1981
Criteria for patient eligibility in a randomized clinical trial can be used to improve the design of observational case-control studies. The new strategy has been illustrated in a case-control investigation of whether lidocaine prophylaxis prevents death in patients with acute myocardial infarction. From among patients hospitalized with myocardial infarction in ...
Brown A H - - 1981
Global myocardial ischaemia improves intracardiac operating conditions but damages the myocardium. Propranolol should reduce this damage but may impair postoperative myocardial contractility. An assessment of its protective effect during 90 minutes of normothermic ischaemia in canine hearts has been made. The early and late changes of contractility caused by low-dose ...
Burmeister W E - - 1981
The importance of cardioselectivity and membrane depressant activity in the ability of beta-adrenergic antagonists to limit myocardial infarct size was assessed in the dog. Infarction was produced by a 60 min occlusion of the left circumflex coronary artery followed by reperfusion into a critical stenosis. Infarct size was significantly reduced ...
Knowles M R - - 1981
Nasal transepithelial electrical potential difference (PD) was estimated in vivo in normal human subjects. The PD between a bridge perfused with Ringer's solution placed on the nasal mucosal surface and a reference electrode in a subcutaneous space was recorded. The magnitude of the PD depended upon the region of the ...
Hori Y - - 1981
This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction. Lidocaine and disopyramide phosphate were compared in terms of their effects on the lowered ventricular fibrillation threshold in experimental myocardial infarction produced by coronary ligation in dogs. The following results were ...
Boudoulas H - - 1981
The net delta left ventricular ejection time index 4 minutes after exercise is prolonged in many patients with coronary artery disease. This prolongation is thought to be due to the lack of response of the ischemic myocardium to adrenergic stimulation and has been proposed as a measure of myocardial ischemia. ...
Haynes R E - - 1981
Bretylium tosylate was compared with lidocaine hydrochloride as initial drug therapy in 146 victims of out of hospital ventricular fibrillation in a randomized blinded trial. An organized rhythm was achieved in 89 and 93 percent and a stable perfusing rhythm in 58 and 60 percent of the patients who received ...
McRitchie R J - - 1981
Both clonidine and labetalol when given by bolus intravenous injection into conscious rabbits produce an initial rise in left ventricular pressure associated with a decrease in myocardial contractility as assessed by left ventricular dP/dt. While clonidine also produces a marked bradycardiac effect, labetalol causes no change in heart rate. Acute ...
Reynolds R D - - 1981
The ability of propranolol to limit myocardial infarct size (IS) following coronary artery occlusion with and without reperfusion into a critical stenosis was assessed in the dog. IS was determined by the nitrobluetetrazolium staining method and expressed as percent of the left ventricle (free wall plus septum). In Series 1 ...
Wiener I - - 1981
Studies of isolated heart muscle and canine models of myocardial ischemia have demonstrated that lidocaine slows conduction in abnormal but not in normal tissues. To determine lidocaine's effects on intraventricular conduction (IVENT) in patients with coronary artery disease (CAD), we studied this agent in seven patients following left anterior descending ...
Okabe E - - 1981
A study was conducted on the effects of perhexiline on myocardial phosphorylase activity, myocardial catecholamine content and heart rate. Phosphorylase a activity and heart rate were investigated as an indicator of sympathetic nerve tone in order to clarify the characteristic of perhexiline with regard to the effects on myocardial metabolism ...
Jaillon P - - 1981
Electrophysiological properties of quinidine and the two isomers of propranolol were compared in pentobarbital-anesthetized dogs using His bundle recordings and programmed stimulation in order to differentiate the effects resulting from beta-blockade from those related to nonspecific membrane-stabilizing effects. Quinidine in the plasma concentration range of 2.7-20 microM/liter resulted in concentration-dependent ...
Mest H J - - 1981
In anaesthetized open-chest dogs tachyarrhythmia (TA) was electrically induced by above-threshold stimuli via the right ventricle. During TA a significant increase in the release of PGE and cyclic AMP of 20% and 40% of the control levels, respectively, was observed in the canine coronary sinus blood (CSB), whereas the level ...
Cairns J A - - 1981
Propranolol was administered intravenously to 12 patients with presumed acute myocardial infarction in the attempt to limit infarct size. Patients' conditions were uncomplicated (heart rate greater than or equal to 60/min, systolic blood pressure greater than or equal to 100 mm Hg, mean pulmonary capillary wedge pressure mean [PCWP] less ...
Keates E U - - 1981
Dipivefrin, an epinephrine prodromal drug, was used in conjunction with timolol maleate to evaluate the safety and effectiveness of combined therapy. Seventeen patients who had used timolol maleate for at least six months added dipivefrin (Group 1) and seven patients who had used dipivefrin for at least six months added ...
Zito R A - - 1981
The regional myocardial concentration of lidocaine after intravenous bolus administration was studied in the setting of myocardial infarction in 27 dogs utilizing a 24 hour old infarct model. Myocardial levels of lidocaine measured by gas chromatography were related to regional myocardial blood flow measured by radioactive microspheres in the same ...
McGrath B P - - 1981
The left anterior descending coronary artery was constricted for eight minutes on two occasions in 13 anaesthetised open-chest dogs. One group (n = 8) was studied before and afer 1 mg . kg-1 propranolol intravenously; a second group (n = 5) served as controls. Simultaneous blood samples were drawn from ...
Wilcox R G - - 1981
The value of beta-blockade and of disopyramide phosphate in the immediate treatment of patients with suspected acute myocardial infarction was assessed in two placebo controlled trials. In the first study 388 patients with suspected acute myocardial infarction were randomly allocated to treatment with propranolol, atenolol, or placebo, and when analysed ...
Brown D L - - 1980
Lidocaine is recognized as a first line drug for ventricular arrhythmias and has recently been used in acute myocardial infarction as prophylaxis against ventricular fibrillation. A 68-year-old man was erroneously given 2 gm of lidocaine by intravenous push and sustained a cardiac arrest. He was treated supportively and had complete ...
Pieper G M - - 1980
31P nuclear magnetic resonance (NMR) spectroscopy was used to ascertain whether propranolol could reduce the development of myocardial acidosis during periods of ischaemic arrest and were studied. Cardiac pH progressively declined during ischaemia from a normal 6.97 +/- 0.02 (n = 23) to 6.09 +/- 0.04 or 5.96 +/- 0.04, ...
Landymore R W - - 1980
Twenty patients undergoing elective myocardial revascularization for coronary insufficiency were divided into two equal groups. In 10 patients, propranolol was discontinued 24 hours before operation while the remaining patients received propranolol until the day of operation. Plasma renin was elevated in the intensive care unit in the control group (p ...
Carruth J E - - 1980
We report the findings in a patient in whom prolongation of the Q-T interval and torsade de pointe ventricular tachycardia occurred as a complication of intracerebral and subarchnoid hemorrhage. The dysrhythmia did not recur after treatment with propranolol. Prolongation of the Q-T interval occurs frequently in patients with subarachnoid hemorrhage, ...
Routledge P A - - 1980
In 15 patients with confirmed myocardial infarction, alpha-1-acid glycoprotein rose significantly from 117 mg/dL at admission to 140 mg/dL at 36 hours (p less than 0.01), but not in 15 age- and sex-matched patients with chest pain only. Twelve patients were given prolonged infusions of lidocaine (2 mg/min). In patients ...
Kizer K W - - 1980
A case of serious decompression sickness complicated by frequent, unifocal, premature ventricular contractions (PVC) is presented. Although no cardiac monitoring was available, a continuous lidocaine infusion was used during recompression treatment to treat the PVCs, and it appeared to produce no untoward side effects. The concerns about using lidocaine in ...
Carlsten A - - 1980
Adrenaline (A) causes gross lesions of the ventricular wall in frogs living both at 12 degrees and 25 degrees. At 12 degrees the sensitivity of the heart to A is higher than at 25 degrees. Single or multiple ventricular aneurysm, provided by A could not be prevented by propranolol. The ...
Bush L R - - 1980
The protective effects of the beta-adrenergic blocking drugs, propranolol and atenolol, were tested in a model of global ischemia and assessed electron microscopically. Cats isolated hearts were perfused retrogradely with arterial blood drawn from donor cats. After a period of equilibration, isolated hearts were rendered globally ischemic for 1 h ...
Zilm D H - - 1980
The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied. Prior to treatment, the incidence of serious and life-threatening arrhythmias was found to be very low and uncorrelated with most biochemical parameters. Propranolol treatment, while efficacious in ...
Gibson D G - - 1980
The effects of trinitrin and propranolol on left ventricular function were compared with those of saphenous bypass grafting in patients with ischaemic heart disease. Simultaneous echocardiograms, apexcardiograms and phonocardiograms were recorded and digitized before and after drug administration or operation. As expected, trinitrin caused a reduction in left ventricular cavity ...
Dennis S C - - 1980
1. Abrupt termination of chronic propranolol therapy has baeen suggested to cause a 'rebound' phenomenon. To investigate this possibility guinea pigs were given propranolol orally for 21 days. 2. At various times over a 10 day period after the last dose hearts were removed and subjected to aerobic perfusion, ischaemia ...
Kates R E - - 1980
A model, employing open-chested, anesthetized dogs, was developed to facilitate the study of myocardial drug disposition. Propranolol was employed as a model compound for initial investigation. Propranolol was administered as either a single i.v. bolus of 0.5 mg/kg or by a stepwise infusion protocol employing three rates: 2.6, 6.5 and ...
Borgia J F - - 1980
Cardiovascular responses initiated by local cutaneous cooling were evaluated in 16 anesthetized dogs of which 8 were pretreated with propranolol. Heart rate, cardiac index (CI), and indices of ventricular contractility were significantly elevated in untreated animals during cold stimulation. Myocardial oxygen uptake (MVo2) and left ventricular work (LVW) were also ...
Roden D M - - 1980
Tocainide, a congener of lidocaine, was used to treat symptomatic ventricular arrhythmias in 19 patients resistant to or unable to tolerate conventional agents. In this highly selected group, 15 showed good initial responses to oral therapy. Ventricular tachycardia was suppressed to a greater extent than isolated ventricular ectopic depolarizations at ...
Abiko Y - - 1980
Myocardial pH was measured continuously with a micro pH electrode inserted into the left ventricular wall in dogs. Anterior descending coronary flow was reduced to about 1/3 of the original flow by partial occlusion of the coronary artery. Myocardial pH decreased from 7.50--7.60 to 7.06--7.24 after partial occlusion. Drugs were ...
Hondeghem L - - 1980
The effects of quinidine and lidocaine on the maximum upstroke velocity (Vmax) of the ventricular myocardial action potential were compared with the effects predicted by a model over a wide range of driving rates, rhythm disturbances and holding potentials. These rate-, rhythm- and voltage-dependent effects were accurately predicted by the ...
Klein M D - - 1980
The antiarrhythmic efficacy and pharmacokinetics of tocainide, an oral analog of lidocaine, was evaluated in 18 hospitalized convalescing myocardial infarction patients. Holter ECG tapes were recorded daily during two-day placebo therapy preceding and succeeding two days of tocainide treatment. Left ventricular function was characterized from prior or subsequent arteriographic studies ...
Chiong M A - - 1980
The effects of 80 microM dl-propranolol on left ventricular (LV) performance, energy stores, and creatine kinase (CK) release were studied in a modified Langendorff rabbit heart preparation during 75 min of aerobic perfusion and postanoxic reoxygenation. The data showed that this concentration of propranolol, which blocked the effects of beta-adrenergic ...
Ettinger P O - - 1980
Potassium chloride infusion into the left anterior descending coronary artery induces a sequence of events analogous to those occurring during acute transmural ischemia. These include ST elevation, intramural conduction delay, ventricular techyarrhythmias and fibrillation. The influence of antiarrhythmic agents in an intact anesthetized canine model have not previously been tested. ...
Kyriakidis G - - 1980
To obviate the myocardial depressant action of propranolol, the use of this drug in combination with a positive inotropic agent, mannitol, was studied in the ischemic heart of the dog. Mannitol (25%) administered prior to propranolol augmented myocardial contractility, as shown by an upward shift of the relationship between the ...
Wilcox R G - - 1980
The value of beta-blockade for suspected acute myocardial infarction was assessed by determining the six-week and one-year mortality rates in patients started on propranolol, atenolol, or placebo immediately on entry to a coronary care unit. A total of 388 patients entered this double-blind, randomised study, and when analysed on the ...
Hillis W S - - 1980
1 The cardiovascular effects of the beta-adrenoceptor blocking drugs, propranolol and acebutolol, on regional coronary blood flow and left ventricular function have been investigated in the conscious dog with developing myocardial infarction. 2 Propranolol (1 to 1.5 mg/kg) or acebutolol (4 to 5 mg/kg) were administered intravenously 2 to 3 ...
von Bibra H - - 1980
To assess the acute and chronic effects of propranolol on left ventricular wall motion, simultaneous, echo-, apex-, and phonocardiograms were recorded in 10 normal subjects and in 16 patients with ischaemic heart disease, nine with co-ordinate (group A) and seven with incoordinate (group B) contraction in the control site. Records ...
Jebavý P - - 1980
Pulmonary gas exchange was evaluated after 10 mg i.v. propranolol in 12 patients 3-6 months after acute myocardial infarction undergoing haemodynamic examination in our outpatient department. None of them exhibited clinical signs of heart failure or obstructive airways disease. Routine spirometric examination was normal in all patients. Propranolol led to ...
Renard M - - 1980
Intravenous mexiletine (250 mg in 10 min) given to patients at the acute stage of a myocardial infarction was responsible of a mild decrease of the left ventricular function; two of our patients presented bradycardia with hypotension, immediately corrected by atropine (i.v.). Adverse hemodynamic effects are seldom reported after oral ...
Ishii Y - - 1980
Electrophysiological studies were performed to see the effects of lidocaine on the conduction system, particularly sinus node and atrium in 40 patients of SSS, using HBE recordings, rapid atrial pacing and atrial extrastimulus technique. Sinus cycle length, PA (P'A), AH, HV intervals, calculated SACT, and refractory periods of atrium, AV ...
Sugiyama S - - 1980
This study was designed to determine whether or not verapamil and propranolol affect the lowering of the ventricular multiple response threshold (VMRT) that is seen following release of a previously ligated coronary artery. In mongrel dogs, the left anterior descending coronary artery was occluded for 15 min and then the ...
Baker K M - - 1980
Administration of potent vasodepressor agents such as the angiotensin converting enzyme inhibitor, captopril, may precipitate myocardial ischemic events in patients with coronary artery disease, particularly if this treatment is preceded by a discontinuation of beta-blocking drugs such as propranolol. In one case studied, a patient experienced three episodes of angina ...
Ogawa K - - 1980
The effects of ischemic and beta-blocker on myocardial cyclic nucleotides (cyclic AMP and cyclic GMP) of dogs were studied. The concentration of cyclic AMP in both infarcted and noninfarcted area 60 min after the ligation of the proximal part of the left anterior descending coronary artery to significantly higher than ...
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