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Langhorn R R Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Frederiksberg C, - - 2014
Myocardial injury detected by cardiac troponin I and T (cTnI and cTnT) in cardiac disease is associated with increased risk of death in humans and dogs. Presence of myocardial injury predicts long-term death in cats with hypertrophic cardiomyopathy (HCM), and ongoing myocardial injury reflects change in left ventricular wall thickness ...
LaszczyƄska Olga O aInstitute of Public Health of the University of Porto bDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School cHeart Failure Clinic, Department of Internal Medicine, Centro Hospitalar de São João dCardiovascular Research and Development Unit, University of Porto Medical School, Porto, - - 2014
Validation of the Seattle Heart Failure Model (SHFM) for predicting the risk of death in a population different than the derivation cohort. In a retrospective analysis of a cohort of chronic heart failure patients with left ventricular systolic dysfunction, consecutively referred between 2000 and 2011, we computed the score, according ...
Ostman-Smith Ingegerd I Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. Electronic address: - - 2014
The sensitivity and specificity of the electrocardiogram for the diagnosis of left ventricular hypertrophy of different etiologies are described. The sensitivity of the electrocardiogram for detecting left ventricular pressure overload is substantially lower (<35%) than the sensitivity for detecting evidence of a cardiomyopathy (55% to around 87%). Attention is drawn ...
Worden Nicole E NE Department of Internal Medicine, The Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA, - - 2014
Correction for soft tissue signal attenuation can improve the diagnostic accuracy of single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The aim of this study was to correlate SPECT-MPI findings with clinical outcomes in patients who underwent stress imaging in the supine position, who also underwent "second look" stress imaging ...
Rao Ashwin L AL Department of Family Medicine, University of Washington, Seattle, - - 2014
Wolff-Parkinson-White (WPW) is a cardiac conduction system disorder characterized by abnormal accessory conduction pathways between the atria and the ventricles. Symptomatic patients classically present with palpitations, presyncope, or syncope that results from supraventricular tachycardia. While rare, sudden cardiac death may be the first manifestation of underlying disease and occurs more ...
Tekkatte Roopa R Cardiff and Vale University Health Board, United - - 2014
Hypertrophic cardiomyopathy's (HCM) association with sudden cardiac death is well recognised. The risk of sudden cardiac death is known to increase when there is a history of unexplained syncope, abnormal blood pressure response during exercise, severe left ventricular hypertrophy or a family history of unexplained death. Implantable Cardioverter Defibrillator (ICD) ...
Cassese Salvatore S Deutsches Herzzentrum, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address: - - 2014
The Nobori is a new-generation, biodegradable-polymer coated, biolimus-eluting stent (BES) that has recently been investigated in several randomized trials with inconsistent results. The aim of this study was to assess the efficacy and safety of Nobori BES versus other drug-eluting stents (DES) in patients treated with percutaneous coronary intervention (PCI). ...
Jin Yan Y Department of Cardiac Surgery, General Hospital of Shenyang Military Area Command, Shenyang City, - - 2014
Early death following coronary artery bypass graft (CABG) surgery tends to occur in coronary heart disease (CHD) patients with significantly decreased left ventricular function. The clinical data of 231 patients with preoperative left ventricular ejection fraction (LVEF) ≤35% who underwent CABG were retrospectively analyzed from June 2007 to October 2012. ...
Varenhorst Christoph C Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden Uppsala Clinical Research Center, Uppsala University, Uppsala, - - 2014
To describe specific causes of death and evaluate whether bleeding events and infection contributed to mortality in all ticagrelor-treated and clopidogrel-treated patients with acute coronary syndromes. In the PLATelet inhibition and patient Outcomes (PLATO) trial, ticagrelor significantly reduced rates of vascular and total death compared with clopidogrel. In the 905 ...
Greve Anders M AM Department of Medicine B2142, The Heart Center, Rigshospitalet, Copenhagen, Denmark. Electronic address: - - 2014
Hypertension and coronary heart disease are common in aortic stenosis (AS) and may impair prognosis for similar AS severity. Different changes in the electrocardiogram may be reflective of the separate impacts of AS, hypertension, and coronary heart disease, which could lead to enhanced risk stratification in AS. The aim of ...
López-Ayala Jose María JM Department of Cardiology, University of Murcia, Virgen de la Arrixaca University Hospital, Murcia, - - 2014
Risk stratification for sudden death in arrhythmogenic right ventricular cardiomyopathy (ARVC) is challenging in clinical practice. We lack recommendations for the risk stratification of exclusive left-sided phenotypes. The aim of this study was to investigate genotype-phenotype correlations in patients carrying a novel DSP c.1339C>T, and to review the literature on ...
Liu Jian J University of Alabama at - - 2014
High fat, low carbohydrate diets (HFLCD) are often eaten by humans for a variety of reasons, but the effects of such diets on the heart are incompletely understood. We evaluated the impact of HFLCD on myocardial ischemia / reperfusion (I/R) using an in vivo model of left anterior descending (LAD) ...
Empana Jean-Philippe JP Paris Cardiovascular Research Centre (PARCC), INSERM UMRS 970, Sorbonne Paris Cité, Paris France Paris Sudden Death Expertise Centre, France jean-philippe.empana@inserm.fr - - 2014
The pattern of coronary occlusion might contribute to the onset of ventricular arrhythmia and sudden cardiac death (SCD). We hypothesized that the concentrations of microparticles might differ between SCD and ST-elevation myocardial infarction (STEMI) patients without rhythmic disturbances. The study sample includes consecutive patients hospitalized in two French tertiary centres ...
Otsuka Yoritaka Y Department of Cardiology, Fukuoka Wajiro Hospital, 2-2-75, Wajirogaoka, Higashi-ku, Fukuoka, 811-0213, Japan, - - 2014
In-stent restenosis (ISR) has long remained as the major limitation of coronary stenting. The use of drug-eluting stent (DES) reduces the risk of repeat revascularization without an increase of death and myocardial infarction, compared to the standard bare metal stents. DES has also demonstrated markedly to reduce ISR for complex ...
Ugur Murat M aDepartment of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul bDepartment of Cardiology, Mehmet Akif Ersoy Cardiovascular and Thoracic Surgery Center, Training and Research Hospital, Istanbul cDepartment of Cardiology, Marmara University, School of Medicine, Istanbul dDepartment of Cardiology, Ankara Numune Training and Research Hospital, Ankara eDepartment of Cardiology, Vakif University, School of Medicine, Istanbul fKadirli State Hospital Clinic of Cardiology, Osmaniye, - - 2014
The platelet to lymphocyte ratio (PLR) has been investigated as a new predictor for cardiovascular risk. The aim of the present study was to investigate the prognostic role admission PLRat admission in predicting in-hospital and early mortality in patients presenting with ST segment elevation myocardial infarction (STEMI). A total of ...
Perez Paulina P Department of Vascular Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Facultad de Medicina, Universitat Autónoma de Barcelona, - - 2014
Cilostazol increases the walking distance in patients with intermittent claudication, but there is scarce evidence of any effect on the risk for subsequent ischemic events, bleeding or death. We used data from the FRENA Registry to compare the clinical outcome in stable outpatients with intermittent claudication, according to the use ...
Schelde Astrid Blicher AB Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: - - 2014
The impact of co-morbidity on the cardiovascular risk after single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) remains unclear. We examined the association between a normal versus abnormal SPECT MPI scan on 10-year risk of myocardial infarction, stroke, and all-cause death, overall and according to co-morbidity level. We identified ...
Marui Akira A Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: - - 2014
Ischemic heart disease is a major risk factor for morbidity and mortality in patients with end-stage renal disease. However, long-term benefits of percutaneous coronary intervention (PCI) relative to coronary artery bypass grafting (CABG) in those patients is still unclear in the drug-eluting stent era. We identified 388 patients with multivessel ...
Hund Thomas J TJ The Ohio State University Wexner Medical Center, Columbus, - - 2014
Despite major breakthroughs in cardiovascular diagnostics and therapies over the past century, diseases of the heart remain the number one cause of death in the United States, nearing 600,000 deaths per year.(1) Most of these deaths (200,000-400,000/year(2)) are due to cardiac arrhythmia where syncope and sudden death are often the ...
White Harvey H Green Lane Cardiovascular Service, Auckland City Hospital, Private Bag 92024, Victoria St West, Auckland, 1142, New Zealand, - - 2014
The new third universal definition of myocardial infarction (MI) is based on troponin elevation together with ischemic symptoms, ischemic ECG changes, and imaging evidence. MIs are classified into five types as to whether they are spontaneous, secondary to imbalance between coronary artery blood supply and demand, related to sudden death, ...
Mushtaq Saima S Centro Cardiologico Monzino, IRCCS, Milan, - - 2014
The goal of this study was to determine the long-term prognostic value of coronary computed tomography angiography (CTA) in a large coronary artery bypass graft (CABG) population. Coronary CTA has shown prognostic utility in patients without previous revascularization. However, prognostication with coronary CTA in CABG patients has not been fully ...
Ahmad Tariq T Division of Cardiology, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North - - 2014
The aim of this study was to determine whether biomarkers of myocardial stress and fibrosis improve prediction of the mode of death in patients with chronic heart failure. The 2 most common modes of death in patients with chronic heart failure are pump failure and sudden cardiac death. Prediction of ...
Trenson Sander - - 2014
Mitral annular calcification is a degenerative process. It is mostly asymptomatic. As the calcification becomes more extensive it might be mistaken for an intracardiac tumour. Mitral annular calcification predicts cardiovascular events, cardiovascular death and overall death. It is predictive of a doubling of the stroke risk. Extensive mitral annular calcification ...
Santos Astrid Meireles - - 2014
Background: Sudden death is the leading cause of death in Chagas disease (CD), even in patients with preserved ejection fraction (EF), suggesting that destabilizing factors of the arrhythmogenic substrate (autonomic modulation) contribute to its occurrence. Objective: To determine baroreflex sensitivity (BRS) in patients with undetermined CD (GI), arrhythmogenic CD with ...
Naruse Yoshihisa Y Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, - - 2014
-We recently showed that the presence of early repolarization (ER) increases the risk of ventricular fibrillation occurrences in the early phase of acute myocardial infarction (AMI). This study aimed to clarify whether an association exists between ER and occurrences of ventricular tachyarrhythmias (VT/VF) or sudden death in the chronic phase ...
Head Stuart J SJ Erasmus University Medical Center, Rotterdam, The - - 2014
Coronary artery bypass grafting (CABG) has been considered the standard of care for patients with three-vessel disease (3VD), but long-term comparative results from randomized trials of CABG vs. percutaneous coronary intervention (PCI) using drug-eluting stents (DES) remain limited. Patients with de novo 3VD or left main disease were randomly assigned ...
Bourantas Christos V CV Thoraxcenter, Erasmus Medical Center, Rotterdam, The - - 2014
To investigate the long-term prognostic implications of coronary calcification in patients undergoing percutaneous coronary intervention for obstructive coronary artery disease. Patient-level data from 6296 patients enrolled in seven clinical drug-eluting stents trials were analysed to identify in angiographic images the presence of severe coronary calcification by an independent academic research ...
Ripley David P - - 2014
Aberrant coronary arteries represent a diverse group of congenital disorders. Post-mortem studies reveal a high risk of exercise-related sudden cardiac death in those with an anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS) with an inter-arterial course. There is little documentation of lifetime history and long-term follow-up ...
Magro Michael M Department of Cardiology, Bern University Hospital, Bern, Switzerland; Thoraxcenter, Erasmus University Hospital, Rotterdam, The - - 2014
To investigate the performance of the MI Sxscore in a multicentre randomised trial of patients undergoing primary percutaneous coronary intervention (PPCI). The MI Sxscore was prospectively determined among 1132 STEMI patients enrolled into the COMFORTABLE AMI trial, which randomised patients to treatment with bare-metal (BMS) or biolimus-eluting (BES) stents. Patient- ...
El-Refai Mostafa M aDepartment of Internal Medicine bHeart and Vascular Institute cDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan dMid America Heart Institute, Kansas City, Missouri eCenter for Health Services Research, Henry Ford Hospital, Detroit, Michigan, - - 2014
Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) have been established as a mainstay of heart failure treatment. Current data are limited and conflicting regarding the consistency of ACE/ARB benefit across race groups in heart failure. This study aims to clarify this point. This was a retrospective study ...
Menon Shaji C SC Division of Pediatric Cardiology, University of Utah, 100 N. Mario Capecchi Drive, Salt Lake City, UT, 84113, USA, - - 2014
In other cardiomyopathies, cardiac magnetic resonance imaging (CMR)-derived myocardial delayed enhancement (MDE), a marker of myocardial fibrosis, is a risk factor for sudden cardiac death (SCD). In Duchenne muscular dystrophy (DMD), the prognostic value of MDE for ventricular arrhythmias and death is unknown. This study aimed to evaluate associations between ...
Bourantas Christos V CV Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, - - 2014
Objectives: To investigate the prognostic implications of the presence of severe lesion calcification in patients undergoing coronary artery bypass graft (CABG) operation. Background: There is robust evidence that lesion calcification is a predictor of worse prognosis in patients undergoing percutaneous coronary intervention; however, there is limited data about the prognostic ...
Labriola Laura L Department of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, - - 2014
In HD patients, the optimal choice of dialysate K concentration is of paramount importance. Recent large observational studies have documented an association between low dialysate K concentration (< 2 or even <3 mEq/L) and a higher risk of sudden death. In this review, we first briefly discuss the available data concerning ...
Hookana Eeva E Department of Internal Medicine, University of Oulu , Oulu , - - 2014
Aims. Idiopathic myocardial fibrosis (IMF) was observed to be the most prevalent autopsy finding in the victims of sudden cardiac death (SCD) under the age of 40 years in the FinGesture cohort. To elucidate further the mechanisms of IMF, we examined the collagen composition from the myocardial samples taken from ...
Tong Guoxin G Department of Cardiology, Beijing Anzhen Hospital, Capital Medical - - 2014
The predictive value of stromal cell-derived factor-1 (SDF-1) has not been established in patients with non-ST elevation acute coronary syndrome (non-STEACS). A total of 678 consecutive patients with non-STEACS and moderate to high TIMI (Thrombolysis In Myocardial Infarction) risk scores were recruited. All patients underwent an early invasive strategy and ...
Dalen J E JE Department of Medicine, University of Arizona College of Medicine. Electronic address: - - 2014
Heart disease was an uncommon cause of death in the US at the beginning of the 20th century. By mid-century it had become the commonest cause. After peaking in the mid 1960s , the number of heart disease deaths began a marked decline that has persisted to the present. The ...
Singh Mandeep M Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Electronic address: - - 2014
To determine the causes and risk of death after percutaneous coronary interventions (PCIs) and to compare the discriminatory ability of the New York State Risk Score (NYSRS) with the Mayo Clinic Risk Score (MCRS). We studied in-hospital and 30-day mortality after PCI in 4898 patients treated at Mayo Clinic in ...
Peng Liu - - 2014
Acute myocardial infarction (AMI) is one of the leading causes for death in both developed and developing countries and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths. The objective of this study was to determine microRNA (miRNA) expression ...
Pires Luis A LA The Heart Rhythm Center and Cardiovascular Medicine, St John Hospital and Medical Center, Detroit, - - 2014
High left ventricular (LV) pacing threshold (PT) may in some cases indicate the presence of scarred myocardium, a predictor of poor outcome in CRT treated patients. We hypothesized that intraoperative LVPT can be used to determine echocardiographic and clinical responses to CRT. The study comprised 975 patients enrolled in the ...
Lu Di D Department of Cardiovascular and Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, - - 2014
As drug-eluting stent (DES) has almost overcome the disadvantage of frequent restenosis, off-pump coronary artery bypass grafting (OPCAB) has been introduced to avoid complications of cardiopulmonary bypass. However, which approach may promise better outcomes for patients with coronary artery disease remains controversial. Three databases were searched. The outcomes of interest ...
Araki Amane A From the Department of Neurology (A.A., M.K., K.S., H.B., N.S., A.H., T. Mano, Y.H., H.N., H.W., G.S.), Nagoya University Graduate School of Medicine; Institute for Advanced Research (H.B.), Nagoya University; Department of Speech Pathology and Audiology (M.Y.), Aichi-Gakuin University School of Health Science, Nisshin; Department of Cardiovascular Medicine (T. Makiyama), Kyoto University Graduate School of Medicine; Department of Cardiovascular and Respiratory Medicine (S.O., M.F., M.H.), Shiga University of Medical Science, Ohtsu; and Division of Cardiology (S.-i.M.), Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, - - 2014
The aim of this study was to clarify myocardial involvement and its clinical implications in subjects with spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease affecting both neuronal and nonneuronal tissues. Two independent cardiologists evaluated ECGs from a total of 144 consecutive subjects with SBMA. We performed immunohistochemical, immunoblot, ...
De Lorenzo Andrea A Clinica de Diagnostico por Imagem, Av Ataulfo de Paiva 669, Rio de Janeiro, - - 2014
To investigate, in patients with known or suspected coronary artery disease (CAD) undergoing myocardial perfusion single-photon emission computed tomography (MPS), the interaction between patient symptoms and single-photon emission computed tomography (SPECT) results, and their effects on patient outcomes. Previous data have shown that medical treatment may be as beneficial as ...
Nieminen Tuomo T University of Helsinki and Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland; Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, - - 2014
We explored the utility of T-wave alternans (TWA) in predicting mortality in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Maximum TWA was calculated using Modified Moving Average method from continuous electrocardiographic recordings in patients with left ventricular ejection fraction <40% and ventricular tachycardia (VT) ≥4 beats during index hospitalization ...
Hamada Mareomi M Division of Cardiology, Uwajima City Hospital, 1-1 Goten-machi, Uwajima, Ehime 798-8510, Japan. Electronic address: - - 2014
We reviewed the natural history of patients with hypertrophic cardiomyopathy (HCM). The effect of medical treatments on natural history, left ventricular (LV) functions and LV remodeling was also evaluated. Sudden cardiac death and end-stage heart failure are the most serious complications of HCM. Age <30 years and a family history ...
Tompkins Rose - - 2014
Statins are the first line pharmacotherapy for cholesterol reduction. Use of these drugs in large, randomized clinical trials have consistently shown significant reductions in major vascular events including death, myocardial infarction, stroke, and coronary revascularization. The updated guidelines for the treatment of high blood cholesterol from the ACC/AHA, will lead ...
Laribi Said S 1 INSERM, UMRS 942, Biomarkers and cardiac diseases, 75010, Paris, - - 2014
BACKGROUND:Worldwide, cardiovascular diseases and cancer account for approximately 40% of deaths. Certain reports have shown a progressive decrease in mortality. Our main objective was to assess mortality trends related to myocardial infarction (MI), heart failure (HF), and pulmonary embolism (PE). METHODS:MI, HF, and PE were studied as cause of death ...
Tolboom Herman H Division of Cardiovascular Surgery, University Hospital Zürich, Zürich, - - 2014
A severe donor organ shortage leads to the death of a substantial number of patients who are listed for transplantation. The use of hearts from donors after circulatory death could significantly expand the donor organ pool, but due to concerns about their viability, these are currently not used for transplantation. ...
Lindholm Daniel D Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, MTC Building, Uppsala Science Park, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, - - 2014
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown.We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed with and without revascularization within 10 ...
Ifteni Petru P Faculty of Medicine, Transilvania University, Brasov, - - 2014
Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudden "natural" death ...
Bakaeen Faisal G FG Michael E. DeBakey Veterans Affairs Medical Center and the Texas Heart Institute (Drs. Bakaeen and Chu), Houston, Texas 77030; Division of Cardiothoracic Surgery (Drs. Kelly and Ward), University of Minnesota, Minneapolis VAMC, Minneapolis, Minnesota 55417; Department of Cardiothoracic Surgery (Dr. Holman), University of Alabama at Birmingham and the Birmingham VAMC, Birmingham, Alabama 35233; and Division of Cardiothoracic Surgery (Dr. Jessen), University of Texas Southwestern Medical Center, Dallas, Texas - - 2014
Although numerous reports describe the results of off-pump coronary artery bypass grafting (CABG) at specialized centers and in select patient populations, it remains unclear how off-pump CABG affects real-world patient outcomes. We conducted a large, multicenter observational cohort study of perioperative death and morbidity in on-pump (ON) versus off-pump (OFF) ...
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