Search Results
Results 151 - 200 of 4036
1 2 3 4 5 6 7 8 9 10 >
Mehta Shamir R - - 2013
Primary percutaneous coronary intervention (PCI) has become the preferred method of reperfusion for patients with ST-segment elevation myocardial infarction (STEMI) when the procedure can be performed promptly by experts. Anticoagulation is important in patients undergoing primary PCI because it prevents acute thrombus formation at the site of arterial injury and ...
Denollet Johan - - 2013
ObjectiveMethodological considerations and selected null findings indicate the need to reexamine the Type D construct. We investigated whether associations with cardiac events in patients with coronary artery disease (CAD) involve the specific combination of negative affectivity (NA) and social inhibition (SI), or rather the main effect of either trait alone.MethodsIn ...
Tullio Francesca F Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Ospedale S. Luigi, Regione Gonzole,10, 10043, Orbassano (TO), - - 2013
Coronary artery disease is a major cause of morbidity and mortality in the Western countries. Acute myocardial infarction is a serious and often lethal consequence of coronary artery disease, resulting in contractile dysfunction and cell death. It is well known that unbalanced and high steady state levels of reactive oxygen ...
García Rodríguez L A - - 2013
This study evaluated the risk of cardiovascular events associated with the use of proton pump inhibitors (PPIs) in new users of acetylsalicylic acid (ASA) for the secondary prevention of cardiovascular events. Two cohorts of patients aged 50-84 years were identified from UK primary care databases: individuals with a first prescription ...
Bahit Maria Cecilia - - 2013
A substantial portion of patients with atrial fibrillation (AF) also have coronary artery disease (CAD) and are at risk for coronary events. Warfarin is known to reduce these events, but increase the risk of bleeding. We assessed the effects of apixaban compared with warfarin in AF patients with and without ...
Tian Tao - - 2013
Objectives: The clinical outcomes of hypertrophic cardiomyopathy (HCM) are largely unpredictable. This study aimed to investigate the relationship between atrial fibrillation (AF) and its prognostic implications in Chinese patients with HCM. Methods: From 1999 to 2011, 654 unrelated HCM patients were consecutively recruited at Fuwai Hospital. Medical history, including electrocardiographic ...
Benchimol-Barbosa P R - - 2013
The SEARCH-RIO study prospectively investigated electrocardiogram (ECG)-derived variables in chronic Chagas disease (CCD) as predictors of cardiac death and new onset ventricular tachycardia (VT). Cardiac arrhythmia is a major cause of death in CCD, and electrical markers may play a significant role in risk stratification. One hundred clinically stable outpatients ...
White Harvey D - - 2013
To assess whether baseline and change in contemporary sensitive (Siemens Ultra) troponin I (TnI) predict CHD death and MI and the effects of pravastatin on TnI levels and relationship with outcomes. The role of troponins in predicting long-term outcomes in patients with stable coronary heart disease (CHD) is not clearly ...
Wahbi Karim - - 2013
In patients with myotonic dystrophy type 1 (DM1), the mechanisms underlying sudden cardiac death, which occurs in up to 1/3 of patients, are unclear. To study the potential role of Brugada syndrome in ventricular tachyarrhythmias and sudden death in DM1 patients. We screened 914 adult patients included in the DM1 ...
Mahaffey Kenneth W - - 2013
We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these analyses was CV death, MI, and unstable angina ...
Regnault Veronique - - 2013
Although hypertension contributes significantly to worsen cardiovascular risk, blood pressure increment in subjects with heart failure is paradoxically associated with lower risk. The objective was to determine whether pulse pressure and pulse wave velocity (PWV) remain prognostic markers, independent of treatment in heart failure with reduced left ventricular function. The ...
Menahem Samuel - - 2013
A 21 year old university student previously operated during infancy for an unobstructed total anomalous pulmonary venous drainage with an excellent result, was noted on a routine follow up 24h Holter monitor to have multiple pauses related to cardiac asystole, the longest lasting 5.8s and temporally related to marijuana inhalation. ...
Toussi Amir - - 2013
Transient left ventricular apical ballooning syndrome (TLVABS), also known as takotsubo cardiomyopathy, is characterized by transient left ventricular dysfunction, electrocardiographic changes, and release of myocardial enzymes that mimic acute myocardial infarction in patients without angiographic evidence of coronary artery disease. Most patients are post-menopausal women and an emotional or physiologic ...
Bangalore Sripal - - 2013
In randomized clinical trials, procedural myocardial infarction (MI) or spontaneous MI is often weighted equally as a component of a composite clinical end point. An underlying assumption of this approach is that procedural and spontaneous MIs have similar prognostic impact. Our aim was to evaluate the prognostic impact of procedural ...
Martinelli Martino - - 2013
The implantable cardioverter defibrillator (ICD) is better than antiarrhythmic drug therapy for the primary and secondary prevention of all-cause mortality and sudden cardiac death in patients with either coronary artery disease or idiopathic dilated cardiomyopathy. This study aims to assess whether the ICD also has this effect for primary prevention ...
Mentz Robert J - - 2013
We aimed to investigate the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP). AP is a predictor of adverse events in patients with heart failure with reduced EF. The implications of AP in HFpEF are unknown. We analyzed HFpEF patients (EF≥50%) ...
Lyon Robert C - - 2013
Arrhythmogenic right ventricular cardiomyopathy (ARVC) termed a "disease of the desmosome" is an inherited cardiomyopathy that recently underwent reclassification due to the identification of left dominant and biventricular disease forms. Homozygous loss-of-function mutations in the desmosomal component, desmoplakin, are found in patients exhibiting a biventricular form of ARVC; however no ...
Stevenson William G - - 2013
Ventricular arrhythmias may be benign, requiring only evaluation for associated risks and then reassurance, or associated with a risk of sudden death or significant morbidity. Therapies for these arrhythmias have evolved considerably over the past twenty years. For some, a definitive, curative therapy is available in the form of catheter ...
Ng Leong L - - 2013
To both assess the prognostic value of proenkephalin(PENK) levels in acute myocardial infarction(AMI), using NTproBNP and GRACE score as comparators, and to identify levels that might be valuable in clinical decision making. PENK is a stable analyte of labile enkephalins. Few biomarkers predict recurrent AMI. We measured PENK in 1141 ...
Huber Andrew H - - 2013
Circulating total free fatty acid (FFA) levels are elevated early in myocardial infarction (MI) and have been associated with an increase in mortality. We investigated the association of serum unbound FFA (FFAu) levels with mortality in patients presenting with ST-segment elevation MI in the Thrombolysis In Myocardial Infarction II trial. ...
Kirtane Ajay J - - 2013
The present study sought to determine the extent to which adverse angiographic events encountered during percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) are associated with adverse clinical outcomes. Patients with STEMI represent a cohort at particularly high risk of intraprocedural thrombotic events (IPTEs). The overall frequency and implications ...
Berkowitz Aaron L - - 2013
A 50-year-old woman developed multiorgan system failure secondary to sepsis. She became obtunded during a period of hypotension, and cranial CT demonstrated diffuse borderzone infarction. Brain autopsy revealed green pigmentation in areas of infarction due to vascular leakage of bilirubin at sites of blood-brain barrier disruption, mapping the borderzone regions ...
Park Jae-Hyeong - - 2013
-Studies of echocardiographic predictors of response after cardiac resynchronization therapy (CRT) have largely involved single parameters. We hypothesized that combining parameters would be more robust and sought to develop a multi-parametric echocardiographic score for predicting CRT response. -Global longitudinal strain of LV (LVGLS) was added to standard echocardiographic measurements in ...
Pullara A - - 2013
Aim: Takotsubo cardiomyopathy is a cardiac syndrome characterized by reversible left ventricular dysfunction, ischemic changes on electrocardiogram, elevation of cardiac biomarkers, absence of obstructive coronary artery disease in the setting of various stressing conditions. To date, little is known on best clinical management of this syndrome in coronary care units. ...
Carson Peter - - 2013
To assess the effect of the addition of coronary artery bypass grafting (CABG) to medical therapy on mode of death in heart failure. While CABG therapy is widely used in ischemic cardiomyopathy patients, there is no prospective clinical trial data on mode of death. The Surgical Treatment for Ischemic Heart ...
Pandit Anil - - 2013
Aims: Cangrelor is a new antiplatelet agent that has been used in percutaneous coronary intervention (PCI) with mixed results. We aim to review the evidence on the efficacy of cangrelor in comparison to clopidogrel in reducing ischaemic endpoints at 48 hours in patients undergoing PCI in large randomised trials. Methods ...
Biondi-Zoccai Giuseppe - - 2013
Final kissing-balloon inflation is often recommended for percutaneous coronary intervention (PCI) of bifurcation lesions. However, randomized trials focusing on kissing inflation have not confirmed its beneficial impact. We compared outcomes of kissing inflation for PCI of bifurcation lesions, explicitly stratifying results according to stenting strategy. Patients undergoing bifurcation PCI were ...
Hadamitzky Martin - - 2013
Coronary computed tomography angiography (CCTA) has a high accuracy for detection of obstructive coronary artery disease (CAD). Several studies also showed a good predictive value for subsequent cardiac events. However, the follow-up period of these studies was limited to ∼2 years and long-term follow-up data on prognosis out to 5 ...
Bagai Akshay - - 2013
Left ventricular end-diastolic pressure (LVEDP) is frequently measured during primary percutaneous coronary intervention (PCI). However, little is known of this measurement's utility in predicting outcomes or informing treatment decisions. We sought to determine the prognostic value of LVEDP measured during primary PCI for ST-segment elevation myocardial infarction (STEMI). We studied ...
Bohula May Erin A - - 2013
High-sensitivity assays for cardiac troponin enable more precise measurement of very low concentrations and improved diagnostic accuracy. However, the prognostic value of these measurements, particularly at low concentrations, is less well defined.METHODS: We evaluated the prognostic performance of a new high-sensitivity cardiac troponin I (hs-cTnI) assay (Abbott ARCHITECT) compared with ...
Sinan Umit Yasar - - 2013
Resistin, which is derived from the gene of RSTN, belongs to a family of cysteine-rich secretory proteins called resistin-like molecules (RELMs). Increased serum resistin levels are associated with coronary artery disease (CAD) and the risk of cardiovascular death. Patients (n = 214) with an initial diagnosis of stable angina pectoris, ...
Albert Christine M - - 2013
The implantable cardioverter defibrillator (ICD) has been one of the most significant advances made in sudden cardiac death (SCD) prevention. Landmark randomized clinical trials convincingly demonstrated survival benefits of ICD therapy in patients 40 days after myocardial infarction (MI) with left ventricular ejection fraction (LVEF) of less than 30%(1) and ...
Park Kyung Woo - - 2013
Background: The SYNTAX score (SS) and clinical SS (cSS) can assess coronary lesion complexity and are useful indices in predicting outcomes after percutaneous coronary intervention. However, their validity has not been fully investigated in daily practice where "limus"-eluting stents are used. Methods and Results: The SS and cSS were independently assessed from ...
Dogan Kamil Hakan - - 2013
Rupture of the free wall of the left ventricle is a catastrophic complication of acute myocardial infarction. Rarely, free wall rupture is contained by overlying adherent pericardium, producing a pseudoaneurysm of the left ventricle. In this report, a case of a left ventricular pseudoaneurysm due to a previous myocardial infarction ...
Oliveira Gustavo Bernardes de Figueiredo - - 2013
The adipose tissue is considered not only a storable energy source, but mainly an endocrine organ that secretes several cytokines. Adiponectin, a novel protein similar to collagen, has been found to be an adipocyte-specific cytokine and a promising cardiovascular risk marker. To evaluate the association between serum adiponectin levels and ...
Lee Keane K - - 2013
Aldosterone receptor antagonists have been shown in randomized trials to reduce morbidity and mortality in adults with symptomatic systolic heart failure. We studied the effectiveness and safety of spironolactone in adults with newly diagnosed systolic heart failure in clinical practice. We identified all adults with newly diagnosed heart failure, left ...
Carson Peter P Washington DC VA Medical Center, Washington DC. Electronic address: - - 2013
This study sought to assess the effect of the addition of coronary artery bypass grafting (CABG) to medical therapy on mode of death in heart failure. Although CABG therapy is widely used in ischemic cardiomyopathy patients, there are no prospective clinical trial data on mode of death. The STICH (Surgical ...
Doukky Rami - - 2013
Appropriate use criteria (AUC) have been developed to aid in the optimal use of SPECT-myocardial perfusion imaging (MPI), a technique that is a mainstay of risk-assessment for ischemic heart disease. The impact of appropriate use on the prognostic value of SPECT-MPI is unknown. A prospective cohort-study of 1511 consecutive patients ...
Gibbons Raymond J - - 2013
In this issue of Circulation, Doukky et al. report findings from a cohort of 1,511 patients from 11 outpatient community-based practices (20 primary care physicians and 2 cardiologists) in the Chicago metropolitan area. The patients underwent single photon emission computed tomographic myocardial perfusion imaging (SPECT), and were then followed for ...
Marijon Eloi - - 2013
Atrial fibrillation (AF) is associated with increased mortality, but the specific causes of death and their predictors have not been described among patients under effective anticoagulant therapy. The Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial randomized 18,113 patients (71.5±9 years, 64% males, CHADS2 score 2.1±1) to receive dabigatran or ...
Acharya Bodhraj - - 2013
During acute myocardial infarction (AMI), both apoptosis and necrosis of myocardial cells could occur and lead to left ventricular (LV) functional decline. Here we determined whether in vivo imaging signals of myocardial cell death by ApoPep-1 (CQRPPR), a peptide probe that binds to apoptotic and necrotic cells through histone H1, ...
Gerger Daniel - - 2013
Aim of this study was to assess pathomorphologic findings (PATHO) in patients with echocardiographically (ECHO) diagnosed left ventricular hypertrabeculation/noncompaction. ECHO-criteria for LVHT were: >3 trabeculations, moving synchronously with the compacted myocardium, and forming the noncompacted part of a two-layered myocardium. At autopsy, the hearts were investigated according to the pathologists' ...
Linde Cecilia - - 2013
-Current guidelines recommend cardiac resynchronization therapy (CRT) in mild HF patients with QRS prolongation and ejection fraction (EF) < 30%. To assess the effect of CRT in less severe systolic dysfunction, outcomes in the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) study were evaluated in which patients with ...
Ertelt Konstanze - - 2013
The treatment of calcified coronary lesions by percutaneous coronary intervention has been shown to be associated with poor outcomes and an increased rate of complications. However, the impact of coronary calcification in patients undergoing coronary artery bypass grafting (CABG) is unknown. A total of 755 patients presenting with acute coronary ...
Kakimoto Yu - - 2013
Triphenyltetrazolium chloride (TTC) is one of the most conventional stains to detect infarcted area of the heart in animal experiments. However, its availability and limitations have not been thoroughly discussed in the forensic field. Here, authors stained human hearts with TTC soon after the harvest. Photographs of the samples were ...
Mauri Laura - - 2013
The identification and treatment of the infarct-artery (or culprit) lesion is the primary goal of percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). Expeditious coronary stenting of the thrombosed artery stems ongoing myocardial necrosis and prevents recurrent infarction and death. During emergency angiography and intervention, ...
Fentanes Emilio - - 2013
The quality assurance of a percutaneous coronary intervention (PCI) program is particularly important when the volume of procedures is low in the center. Determine predictors of the 30-day and long-term incidence of stent thrombosis, myocardial infarction, and death from any cause for all PCIs performed at Tripler Army Medical Center ...
Zhang Bo - - 2013
Females with acute myocardial infarction (AMI) have a higher risk of adverse outcomes because of receiving less evidence-based medical care. Our aim was to investigate the gender disparity in early death after ST-elevation myocardial infarction (STEMI) in the current era. A total of 1429 consecutive patients with STEMI in the ...
Hess Connie N - - 2013
Eptifibatide is indicated during percutaneous coronary intervention (PCI) with continuation for 18-24 hours post procedure but is associated with bleeding. We examined the efficacy and safety of shorter post-PCI eptifibatide infusions in high-risk non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients. EARLY ACS patients treated with PCI and eptifibatide were ...
Shammas Nicolas W NW Midwest Cardiovascular Research Foundation, Davenport, - - 2013
In this study, we compare the outcomes of the paclitaxel-eluting stent (PES) versus the everolimus-eluting stent (EES) treated patients at a tertiary medical center and up to 2 years follow-up. Unselected consecutive patients were retrospectively recruited following stenting with PES (159 patients) or EES (189 patients). The primary endpoint of ...
1 2 3 4 5 6 7 8 9 10 >