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Bauters Christophe C Centre Hospitalier Régional et Universitaire de Lille, Lille, France; INSERM U744, Institut Pasteur de Lille, Université de Lille 2, Lille, France; Faculté de Médecine de Lille, Lille, France. Electronic address: - - 2014
There are limited data on the prognosis of patients with stable coronary artery disease (CAD) in modern clinical practice. We conducted a multicenter study enrolling 4,184 outpatients with stable CAD defined as previous myocardial infarction (>1 year ago), previous coronary revascularization (>1 year ago), and/or ≥50% coronary stenosis by angiography. Clinical follow-up ...
Mancini G B John GB University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: - - 2014
The aim of this study was to determine the relative utility of anatomic and ischemic burden of coronary artery disease for predicting outcomes. Both anatomic burden and ischemic burden of coronary artery disease determine patient prognosis and influence myocardial revascularization decisions. When both measures are available, their relative utility for ...
Choo Eun Ho EH Division of Cardiology, Department of Internal Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, , Seoul, - - 2014
β-blockers are the standard treatment for myocardial infarction (MI) based on evidence from the pre-thrombolytic era. The aim of this study was to examine the effect of β-blocker treatment in patients with acute MI and preserved systolic function in the era of percutaneous coronary intervention (PCI). We analysed a multicentre ...
Naksuk Niyada N Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, - - 2014
Preventing sudden cardiac death (SCD) remains a major unsolved problem in contemporary medical practice. As the most common cause of SCD, treatment for ventricular arrhythmias is the target area of interest in research field. While implantable cardioverter-defibrillator (ICD) effectively decreases death from ventricular arrhythmias in highly selected patients, risk of ...
Rabinstein Alejandro A AA Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: - - 2014
Sudden cardiac death can occur after exposure to extreme stress and sometimes as a complication of acute neurologic disease. Excessive adrenergic stimulation of the heart is most likely the responsible mechanism for the majority of cases of sudden cardiac death. The neurocardiogenic injury induced by sympathetic overstimulation can affect the ...
Ghosh Rajeshwary R Sinha Institute of Medical Science and Technology, Kolkata, - - 2014
Excessive aggregation of platelets at the site of plaque rupture on the coronary artery led to the formation of thrombus which is reported to precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been reported to inhibit platelet aggregation and induce thrombolysis through the in situ formation of plasmin. As ...
Holzmann Martin M Departments of Emergency Medicine, Cardiothoracic Surgery and Anesthesiology, Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, - - 2014
Patients with chronic kidney disease have an increased risk of death after myocardial infarction, coronary artery bypass graft surgery (CABG), and percutaneous coronary intervention. We sought to describe the association between chronic kidney disease and long-term cardiovascular outcomes and death in patients who underwent CABG for acute coronary syndromes. All ...
Bang Casper N CN Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, - - 2014
New-onset atrial fibrillation (AF) is reported to increase the risk of death in myocardial infarction (MI) patients. However, previous studies have reported conflicting results and no data exist to explain the underlying cause of higher death rates in these patients. All patients with first acute MI between 1997 and 2009 ...
Yao Hai-Mu HM Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. - - 2014
Previous studies suggest the higher the red blood cell distribution width (RDW) the greater the risk of mortality in patients with coronary artery disease (CAD). However, the relationship between RDW and long-term outcome in CAD patients undergoing percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) remains unclear. This study ...
Skovgaard Dorthe D Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet and University Hospital of Copenhagen, Copenhagen, - - 2014
Cardiotoxicity is a dose-limiting side-effect of cancer chemotherapeutics such as anthracyclines. The drug-induced cardiac toxicity is currently monitored with repeated assessments of the left ventricular ejection fraction (LVEF) using multigated equilibrium radionuclide ventriculography (MUGA) or echocardiography. However, the plasma cardiac biomarker B-type natriuretic peptide (BNP) has been suggested for early ...
Fiedler Lorna R LR British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: - - 2014
Heart failure is one of the paramount global causes of morbidity and mortality. Despite this pandemic need, the available clinical counter-measures have not altered substantially in recent decades, most notably in the context of pharmacological interventions. Cell death plays a causal role in heart failure, and its inhibition poses a ...
Bell James R JR Department of Physiology, University of Melbourne Melbourne, VIC, - - 2014
Ischemic heart disease is a leading cause of death, and there is considerable imperative to identify effective therapeutic interventions. Cardiomyocyte Ca(2+) overload is a major cause of ischemia and reperfusion injury, initiating a cascade of events culminating in cardiomyocyte death, myocardial dysfunction, and occurrence of lethal arrhythmias. Responsive to fluctuations ...
Francia Pietro P Cardiology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, Via di Grottarossa 1035-39, 00189 Rome, - - 2014
International guidelines recommend ICD implantation in patients with severe left ventricular dysfunction of any origin only after careful optimization of medical therapy. Indeed, major randomized clinical trials suggest that suboptimal use of fundamental drugs, such as ACE inhibitors (ACE-i) and beta-blockers, may affect ICD shock-free survival, sudden cardiac death (SCD), ...
Ibrahim Saif S 0000-0003-1565-7243 Department of Internal Medicine, University of Florida College of Medicine, 653-1 West 8th Street, Jacksonville, FL 32209, - - 2014
Sudden cardiac death (SCD) accounts for up to 450,000 deaths every year in the United States (Zipes et al. (2006)). Most cases of sudden cardiac death occur in subjects with no prior history of heart disease (Myerburg et al. (1998)). The incidence of sudden death in a general population has ...
Snyder Michelle L ML Department of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hill, 137 E, Franklin St,, Suite 306, Chapel Hill, NC 27514, USA. - - 2014
Heart failure is sometimes incorrectly listed as the underlying cause of death (UCD) on death certificates, thus compromising the accuracy and comparability of mortality statistics. Statistical redistribution of the UCD has been used to examine the effect of misclassification of the UCD attributed to heart failure, but sex- and race-specific ...
Cain Michael E ME Buffalo, New - - 2014
Between 184,000 and 462,000 Americans die suddenly each year. Fifty percent to 70% of these deaths are due to ventricular tachycardia/fibrillation (VT/VF). We tested whether hibernating myocardium or myocardial sympathetic denervation identifies patients at high-risk for developing VT/VF independently of ejection fraction (EF). Positron emission tomography (PET) was used to ...
Yao Hai-Mu HM Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of - - 2014
To assess both short-term and long-term prognosis in consecutive patients with coronary heart disease treated with drug-eluting stents in a high-volume percutaneous coronary intervention (PCI) centre. Observational cohort study. A hospital in the Henan province, China, between 2009 and 2011. A total of 2533 patients were enrolled. Patients with ST-elevation ...
Takahashi Masafumi M Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical - - 2014
Inflammasomes are multiple protein complexes that serve as molecular platforms to activate caspase-1 and regulate maturation of a potent proinflammatory cytokine, interleukin (IL)-1β, as well as proinflammatory cell death, pyroptosis. Although several types of inflammasomes have been reported so far, recent investigations indicate that the NLRP3 inflammasome recognizes non-microbial danger ...
Buxton Alfred E AE Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, - - 2013
How easy it is to make people believe a lie, and how hard it is to undo that work again! - Mark Twain in Eruption Medicine, like most other human endeavors, goes through fads. These fads are often initiated by persuasive, well-meaning persons who have incomplete grasp of fundamental pathophysiology. ...
Takada Tsuyoshi T Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, - - 2013
It is still controversial whether elevated baseline heart rate (HR) is associated with higher mortality in patients with heart failure (HF) with preserved ejection fraction (HFpEF). We compared the impacts of baseline HR on mortality in patients with HFpEF and those with HF with reduced ejection fraction (HFrEF). We enrolled ...
Urena Marina M Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, - - 2013
Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) following transcatheter aortic valve implantation (TAVI). The objective of this study was to assess the impact of PPI following TAVI on late outcomes in a large cohort of patients. A total of 1,556 consecutive patients without prior ...
Wen Y T YT Center for Translational Medicine, Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, - - 2013
There is considerable discrepancy regarding the protective effects of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) in patients with coronary heart disease (CHD) from the early-phase clinical randomized controlled trials (RCTs). We conducted a meta-analysis of RCTs to address this issue. Pubmed, the Cochrane Central Register of Controlled Trials, and EMBASE ...
Rao B Hygriv BH Senior Consultant Cardiologist and Electrophysiologist, KIMS Hospital, Hyderabad 500003, India. Electronic address: - - 2014
Sudden Cardiac death (SCD) is a major clinical event causing adverse impact on global economy. This review summarizes the available epidemiological data on SCD from different parts of the world. It contrasts the Indian and global perception on the issues influencing data collection, burden of SCD and sudden deaths occurring ...
Kawamoto Osamu O Department of Legal Medicine, Osaka City University Medical, School, Osaka, Japan. - - 2013
Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocardial ischemia in addition to the above-mentioned markers, using ...
Lonn Eva M EM Division of Cardiology, Department of Medicine, McMaster University, Hamilton, ON, - - 2013
Heart rate was proposed as an emergent cardiovascular (CV) risk factor. Previous studies have shown associations between increased heart rate and CV risk in various populations. We aimed to evaluate the prognostic relevance of heart rate in a large contemporaneous medically optimized cohort of patients with stable chronic CV disease. ...
Rapsomaniki Eleni E Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 7BH, - - 2013
The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. Models were developed in a linked electronic health records cohort of ...
Schmidt Morten M Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus, Denmark, - - 2013
Few studies have associated height with cardiovascular diseases other than myocardial infarction. We conducted a population-based 36-year cohort study of 12,859 men born in 1955 or 1965 whose fitness for military service was assessed by Draft Boards in Northern Denmark. Hospital diagnoses for ischemic heart diseases, atrial fibrillation, stroke, and ...
Mechakra Asma A Laboratoire de Neurocardiologie, EA4612, Université Lyon 1, Lyon, F-69003, - - 2013
A variant of the ether-à-go-go related channel (hERG), p.Arg148Trp (R148W) was found at heterozygous state in two infants who died from sudden infant death syndrome (SIDS), one with documented prolonged QTc and Torsade de Pointes (TdP), and in an adult woman with QTc>500ms, atrio-ventricular block and TdP. This variant was ...
Jared Bunch T T Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray Utah. Electronic address: - - 2013
Ventricular arrhythmias in patients with implantable cardioverter defibrillators(ICDs) adversely impact outcomes. Antiarrhythmic approaches to ventricular tachycardia(VT) have variable efficacy and may increase risk of ventricular arrhythmias, worsening cardiomyopathy, and death. Comparatively, VT ablation is an alternative approach that may favorably impact outcomes. To further explore the impact on long-term outcomes ...
Moghimi Narges - - 2013
Sudden unexpected death in epilepsy (SUDEP) affects up to 5000 patients a year in the United States alone. The exact pathophysiologic processes of are unknown. Profound autonomic dysregulation driving cardiac and respiratory dysfunction is likely. Available evidence from monitored deaths suggests that fatal tachyarrhythmias are not primarily responsible although near ...
Biondi-Zoccai Giuseppe - - 2013
Bifurcations remain a challenging subset for percutaneous coronary intervention (PCI). Specifically, it is unclear whether bifurcations on left anterior descending (LAD) coronary arteries have the same prognosis of bifurcations on left circumflex (LCX) or right coronary arteries (RCA). We compared the results of PCI for bifurcation lesions, focusing on target ...
Polat Nihat N Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, - - 2013
Spontaneous coronary artery dissection (SCAD) is a rare and uncommon case of sudden cardiac death and acute coronary syndrome. Herein, we present a 13-year-old boy with chest pain who was diagnosed with acute ST-segment elevation myocardial infarction associated with SCAD, possibly caused by the consumption of an energy drink, which ...
Chan Pak-Hei PH Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 102 Pokfulam Rd., Hong Kong, - - 2013
Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients. The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS. From January 2002 to October 2005, 199 ...
Jordan James E - - 2013
Reperfusion injury is a complex inflammatory response involving numerous mechanisms and pathways. Mechanical tissue resuscitation is a newly described therapeutic strategy that reduces reperfusion injury. This study further investigates potential mechanisms for the protective effects of mechanical tissue resuscitation while utilizing a bio-absorbable matrix. Anesthetized swine were subjected to 80 minutes ...
Meliga Emanuele - - 2013
Aims: Data regarding the impact on clinical outcomes of PCI with DES implantation vs. CABG to treat unprotected left main coronary artery (ULMCA) disease in diabetic patients are still insufficient. The present study evaluated the short-term and long-term results of percutaneous and surgical revascularisation in diabetic patients with ULMCA disease ...
Tian Tao - - 2013
The prognostic significance of myocardial bridging in hypertrophic cardiomyopathy (HCM) remains controversial. This investigation sought to evaluate the impact of myocardial bridging on prognosis of patients with HCM. A total of 298 adult patients (73% male, mean age, 53 ± 12 years) with HCM were retrospectively enrolled at Fuwai Hospital ...
Bougouin Wulfran - - 2013
Limited data are available on long-term prognosis or causes-of-death analysis among survivors of acute myocardial infarction (MI) according to whether or not they developed ventricular fibrillation (VF) during the acute stage of MI. Among 3670 MI patients hospitalized in France in 2005 and enrolled in this prospective follow-up cohort study, ...
Dzudie Anastase - - 2013
To assess the predictive utility of 12-lead electrocardiogram (ECG) abnormalities among Africans with acute heart failure (HF). We used the Sub-Saharan Africa Survey of HF multicenter, prospective cohort study among 1006 acute HF patients, and regressions models to relate baseline ECG findings with all-cause mortality and readmission during a six-month ...
Kinch Westerdahl Annika - - 2013
Several trials have demonstrated improved survival with Implantable Defibrillator (ICD) therapy. The cause and nature of death in the ICD population is insufficiently investigated. The objective of this study was to analyse ICDs from deceased patients to assess the incidence of ventricular tachyarrhythmias, the occurrence of shocks and possible device ...
Ojeifo Oluseyi O Department of Medicine, Massachusetts General Hospital, Boston, - - 2013
This study sought to evaluate the clinical relevance of potential clopidogrel drug-drug interactions. Some studies have demonstrated that statins and calcium-channel blockers (CCBs) may attenuate the pharmacodynamic effects of clopidogrel. The TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38) ...
Gada Hemal H Columbia University Medical Center/New York Presbyterian Hospital and the Cardiovascular Research Foundation, New York, New - - 2013
This study sought to evaluate the long-term safety and efficacy of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in patients with obstructive coronary artery disease. The use of EES compared to PES has been shown to result in improved clinical outcomes in patients undergoing PCI. However, there have been concerns ...
Kim Joon Bum - - 2013
The risks and benefits of a concomitant Maze procedure for patients with LV dysfunction undergoing major cardiac surgery have not yet been elucidated. This study aimed to evaluate the clinical impacts of the Maze procedure in patients with atrial fibrillation and left ventricular (LV) dysfunction. Between January 1999 and March ...
Pahlevan Niema M - - 2013
Sudden death (SD) in young athletes is a shocking and disturbing event with significant societal impact. Previous studies have demonstrated that sudden cardiac death (SCD) is the leading medical cause of SD in athletes. Various structural and pathological cardiovascular abnormalities have identified as the underlying causes of SCD in young ...
Borer Jeffrey S JS Division of Cardiovascular Medicine, The Howard Gilman Institute for Heart Valve Disease and the Schiavone Institute for Cardiovascular Translational Research, State University of New York Downstate Medical Center, New York, New York. Electronic address: - - 2013
A post hoc analysis of Systolic Heart failure treatment with the If inhibitor ivabradine Trial (SHIFT) explored the efficacy and safety of ivabradine in severe heart failure (HF) as denoted by left ventricular ejection fraction (LVEF) ≤20% and/or New York Heart Association (NYHA) class IV. The SHIFT population (LVEF ≤35%, ...
Tuñón José - - 2013
Patients with coronary artery disease may develop not only ischemic events but also heart failure and death due to previous myocardial damage. The purpose of this study was to test the prognostic value of a panel of plasma biomarkers related to vascular (monocyte chemoattractant protein-1 [MCP-1] and soluble tumor necrosis ...
Majithia Arjun A Tufts Medical Center, Boston, Mass. Electronic address: - - 2013
Randomized clinical trials support the use of implantable defibrillators for mortality reduction in specific populations at high risk for sudden cardiac death. Conventional transvenous defibrillator systems are limited by implantation-associated complications, infection, and lead failure, which may lead to delivery of inappropriate shocks and diminish survival. The development of a ...
Mont Erik - - 2013
There are few histologic studies of intracoronary stents found at autopsy. We studied histologic findings of 87 intracoronary stents from 45 autopsy hearts. There were 40 patients with chronically implanted stents and five shorter than 30 days. Of five patients with recent stent placement, the cause of death was related to ...
Cheng Judy W M JW 1Department of Pharmacy - - 2013
Antiplatelet therapy is a cornerstone in coronary artery disease management. However, patients with acute coronary syndrome still remain at risk of recurrent cardiovascular events despite the advance of medical therapy. This article provides a review of antiplatelet agents used in cardiovascular diseases and focus on updates in the past 5 ...
Valente Anne Marie - - 2013
Patients with repaired tetralogy of Fallot (TOF) experience increased rates of mortality and morbidity in adulthood. This study was designed to identify risk factors for death and ventricular tachycardia (VT) in a large contemporary cohort of patients with repaired TOF. Subjects with repaired TOF from four large congenital heart centres ...
Mehta Shamir R - - 2013
Primary percutaneous coronary intervention (PCI) has become the preferred method of reperfusion for patients with ST-segment elevation myocardial infarction (STEMI) when the procedure can be performed promptly by experts. Anticoagulation is important in patients undergoing primary PCI because it prevents acute thrombus formation at the site of arterial injury and ...
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