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Hamada Mareomi M Division of Cardiology, Uwajima City Hospital, 1-1 Goten-machi, Uwajima, Ehime 798-8510, Japan. Electronic address: - - 2014
We reviewed the natural history of patients with hypertrophic cardiomyopathy (HCM). The effect of medical treatments on natural history, left ventricular (LV) functions and LV remodeling was also evaluated. Sudden cardiac death and end-stage heart failure are the most serious complications of HCM. Age <30 years and a family history ...
Tompkins Rose - - 2014
Statins are the first line pharmacotherapy for cholesterol reduction. Use of these drugs in large, randomized clinical trials have consistently shown significant reductions in major vascular events including death, myocardial infarction, stroke, and coronary revascularization. The updated guidelines for the treatment of high blood cholesterol from the ACC/AHA, will lead ...
Laribi Said S 1 INSERM, UMRS 942, Biomarkers and cardiac diseases, 75010, Paris, - - 2014
BACKGROUND:Worldwide, cardiovascular diseases and cancer account for approximately 40% of deaths. Certain reports have shown a progressive decrease in mortality. Our main objective was to assess mortality trends related to myocardial infarction (MI), heart failure (HF), and pulmonary embolism (PE). METHODS:MI, HF, and PE were studied as cause of death ...
Tolboom Herman H Division of Cardiovascular Surgery, University Hospital Zürich, Zürich, - - 2014
A severe donor organ shortage leads to the death of a substantial number of patients who are listed for transplantation. The use of hearts from donors after circulatory death could significantly expand the donor organ pool, but due to concerns about their viability, these are currently not used for transplantation. ...
Lindholm Daniel D Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, MTC Building, Uppsala Science Park, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, - - 2014
The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown.We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed with and without revascularization within 10 ...
Ifteni Petru P Faculty of Medicine, Transilvania University, Brasov, - - 2014
Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudden "natural" death ...
Bakaeen Faisal G FG Michael E. DeBakey Veterans Affairs Medical Center and the Texas Heart Institute (Drs. Bakaeen and Chu), Houston, Texas 77030; Division of Cardiothoracic Surgery (Drs. Kelly and Ward), University of Minnesota, Minneapolis VAMC, Minneapolis, Minnesota 55417; Department of Cardiothoracic Surgery (Dr. Holman), University of Alabama at Birmingham and the Birmingham VAMC, Birmingham, Alabama 35233; and Division of Cardiothoracic Surgery (Dr. Jessen), University of Texas Southwestern Medical Center, Dallas, Texas - - 2014
Although numerous reports describe the results of off-pump coronary artery bypass grafting (CABG) at specialized centers and in select patient populations, it remains unclear how off-pump CABG affects real-world patient outcomes. We conducted a large, multicenter observational cohort study of perioperative death and morbidity in on-pump (ON) versus off-pump (OFF) ...
Liu Xiaoyan X State Key Laboratory of Cardiovascular Disease, Arrhythmia Diagnosis and Treatment Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of - - 2014
Chronic heart failure with reduced ejection fraction (CHF-REF) remains a major public health problem with high morbidity and mortality, but the data on current treatment status and long-term prognosis in China were still missing. Among prospectively recruited 2368 patients with CHF-REF in 10 hospitals, 2154 patients provided complete followed data. ...
Song Pil Sang PS Division of Cardiology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Republic of - - 2014
The efficacy and safety of adding cilostazol to aspirin plus clopidogrel (triple antiplatelet therapy, TAPT) have not been fully evaluated in complex percutaneous coronary intervention (PCI). We sought to investigate whether TAPT after PCI for bifurcation lesions improves long-term clinical outcomes. Consecutive patients undergoing PCI for bifurcation lesions were enrolled ...
- - 2014
Elevated lipoprotein-associated phospholipase A2 activity promotes the development of vulnerable atherosclerotic plaques, and elevated plasma levels of this enzyme are associated with an increased risk of coronary events. Darapladib is a selective oral inhibitor of lipoprotein-associated phospholipase A2. In a double-blind trial, we randomly assigned 15,828 patients with stable coronary ...
Bandstein Nadia N Department of Emergency Medicine, Karolinska University Hospital, Huddinge, Sweden; Department of Internal Medicine, Karolinska Institutet, Stockholm, - - 2014
This study sought to evaluate if an undetectable (<5 ng/l) high-sensitivity cardiac troponin T (hs-cTnT) level and an electrocardiogram (ECG) without signs of ischemia can rule out myocardial infarction (MI) in the emergency department (ED). Chest pain is a common symptom often associated with benign conditions, but may be a sign ...
Shah Sana S Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, 1462 Clifton Road NE, Room 529, Atlanta, GA, - - 2014
Coronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients ...
Adlbrecht Christopher C Department of Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, - - 2014
The Occluded Artery Trial (OAT) randomized stable patients (n=2201) >24h (calendar days 3-28) after myocardial infarction (MI) with totally occluded infarct-related arteries (IRA), to percutaneous coronary intervention (PCI) with optimal medical therapy, or optimal medical therapy alone (MED). PCI had no impact on the composite of death, reinfarction, or class ...
Zorzi Alessandro A Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, - - 2014
Identification of patients with non-ST elevation acute myocardial infarction (NSTEMI) at higher risk of in-hospital life-threatening ventricular arrhythmias (LT-VA) and death is crucial for determining appropriate levels of care/monitoring during hospitalisation. We assessed predictors of in-hospital LT-VA and all-cause mortality in a consecutive series of NSTEMI patients. We prospectively studied ...
Son Gi Hoon GH Department of Legal Medicine, These authors contributed equally to this work; Department of Anatomy and Institute of Human Genetics, College of Medicine, Korea University, Seoul 136-705, - - 2014
Sudden cardiac death (SCD), which is primarily caused by lethal heart disorders resulting in structural and arrhythmogenic abnormalities, is one of the prevalent modes of death in most developed countries. Myocardial ischemia, mainly due to coronary artery disease, is the most common type of heart disease leading to SCD. However, ...
Cerillo Alfredo Giuseppe AG Operative Unit of Cardiac Surgery, "G. Pasquinucci" Hospital, "G. Monasterio" Foundation, Massa, Italy. Electronic address: - - 2014
There is strong clinical and experimental evidence that altered thyroid homeostasis negatively affects survival in cardiac patients, but a negative effect of the low triiodothyronine (T3) syndrome on the outcome of coronary artery bypass grafting (CABG) has not been demonstrated. This study was designed to evaluate the prognostic significance of ...
Naganuma Toru T Department of Cardio-Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, - - 2014
The aim of this study was to report the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) for ostial/midshaft lesions in an unprotected left main coronary artery (ULMCA). Data regarding outcomes in these patients are limited. Of a total of ...
Tatlisu Mustafa A MA Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, - - 2014
The interval between the peak and the end of the T wave (Tp-e interval) on 12-lead ECG is a measure of transmural dispersion of repolarization and may be related to malignant ventricular arrhythmias. The objective of this study was to investigate whether the Tp-e interval predicts in-hospital and long-term mortality ...
Carillo Sylvain S Inserm U961, cardiology, centre d'investigations cliniques CIC9501, institut Lorrain du cœur et des vaisseaux, CHU de Nancy, 2, avenue du Morvan, 54500 Vandoeuvre-Lès-Nancy, France. Electronic address: - - 2014
Differential outcomes in patients with acute systolic heart failure (HF) complicating acute myocardial infarction (AMI) and the efficacy of mineralocorticoid receptor antagonists according to non-ST-segment and ST-segment elevation myocardial infarction (NSTEMI, STEMI) status has not been specifically investigated. In the EPHESUS study, 6632 patients with acute HF and left ventricular ...
Zaman Sarah S Cardiology Department, Westmead Hospital, Corner Darcy and Hawkesbury Roads, Westmead, Sydney, NSW 2145, - - 2014
The optimal left ventricular ejection fraction (LVEF) to select patients early post myocardial infarction (MI) for risk stratification for prevention of sudden cardiac death (SCD) in the era of primary percutaneous coronary intervention (PPCI) is unknown.METHODS AND RESULTS: Consecutive patients (n = 1722) treated with PPCI for ST-elevation MI underwent ...
Chen Shao-Liang SL Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Gansu Provincial People's Hospital, Lanzhou, - - 2014
Evidences concerning the predictive value of baseline inflammatory biomarkers after drug-eluting stent (DES) placement are controversial, mainly because the use of statin was not precisely defined. The aim was to compare the differences between interleukin (IL)-6 and high-sensitivity C-reactive protein (hs-CRP) in predicting cardiovascular events 2 years after stenting in ...
Ferrero Jose M JM Departamento de Ingeniería Electrónica, Instituto I3BH, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, - - 2014
Ischaemic heart disease is considered as the single most frequent cause of death, provoking more than 7 000 000 deaths every year worldwide. A high percentage of patients experience sudden cardiac death, caused in most cases by tachyarrhythmic mechanisms associated to myocardial ischaemia and infarction. These diseases are difficult to ...
McGoey Robin R RR Associate Professor of Pathology and Residency Program Director in the Department of Pathology at Louisiana State University School of Medicine in New - - 2014
A 35-year-old, recently deceased woman with a medical history known only to include Hepatitis C and alcohol abuse was transferred to the autopsy service for an unrestricted autopsy under coroner authorization following a sudden unexplained death. External examination revealed marked scleral icterus and cutaneous jaundice. Internal examination was remarkable for ...
de Waha Antoinette A Deutsches Herzzentrum, Technische Universität and DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, - - 2014
Aims: Arterial plaque rupture and thrombus characterise ST-elevation myocardial infarction (STEMI) and may aggravate delayed arterial healing following durable polymer drug-eluting stent (DP-DES) implantation. Biodegradable polymer (BP) may improve biocompatibility. We compared long-term outcomes in STEMI patients receiving BP-DES vs. durable polymer sirolimus-eluting stents (DP-SES). Methods and results: We pooled ...
Liu Mao M 1Department of Cardiology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai; 2Department of Nephrology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, - - 2014
The optimal duration of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation is still unclear. We conducted a meta-analysis of randomized trials to assess the optimal duration of DAPT after DES implantation. Articles were identified through a literature search of EMBASE, Pubmed, Europubmed and the Cochrane Library until November ...
Basavarajaiah Sandeep S Interventional Cardiology Unit, EMO-GVM Centro Cuore Columbus, Milan, - - 2014
Objectives: To report very-long term follow-up of "Full Metal Jacket'' (FMJ) percutaneous coronary interventions in long-diffuse coronary lesions with drug-eluting stents. Background: Percutaneous coronary intervention for long-diffuse lesions may result in FMJ, which is not preferred by some operators due to long term risk of restenosis and stent-thrombosis. The data ...
Thorén Emma E Department of Cardiothoracic Surgery, Uppsala University Hospital , Uppsala , - - 2014
Abstract Objectives. To investigate the association between postoperative atrial fibrillation (POAF) and cause-specific death after coronary artery bypass grafting (CABG) over time. Design. The cohort included 6821 patients undergoing primary isolated CABG between 1996 and 2009. Survival analyses using Cox proportional hazards determined the association between POAF and late mortality ...
Savvopoulos Christos A CA Department of Nuclear Medicine, University Hospital of Patras, University of Patras, Medical School, Rion, 26500, Patras, - - 2014
Previous studies advocate the use of attenuation correction in myocardial perfusion scintigraphy (MPS) for patient risk stratification. Six-hundred and thirty-seven unselected patients underwent Tl-201 MPS by a hybrid SPECT/CT system. Attenuation-corrected (AC) and non-corrected (NAC) images were interpreted blindly and summed stress scores (SSS) were calculated. Study endpoints were all-cause ...
Kumada Yoshitaka Y Department of Cardiovascular Surgery, Matsunami General - - 2014
Background: Although revascularization via coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) has been widely performed, there are limited data on which procedure is best in hemodialysis (HD) patients. Methods and Results: This 10-year follow-up study consisted of 997 HD patients electively undergoing coronary revascularization (CABG, n=210; PCI, n=787). With ...
Bo L L Division of Cardiovascular Research, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, - - 2014
Autophagy is required for the maintenance of cardiomyocytes homeostasis. However, the abnormal autophagy could lead to the development of heart failure. Autophagy is enhanced during myocardial ischemia/reperfusion; it remains to elucidate the molecular regulation of autophagy. We report here that miR-325, ARC and E2F1 constitute an axis that regulates autophagy. ...
Lin Jeng-Feng JF Division of Cardiology (JFL, SYH, KHY, HHC, STC, TYW, WTH, YLK), Department of Internal Medicine, Buddhist Tzu-Chi Hospital, Taipei Branch, Taiwan; School of Medicine (JFL, SYH, KHY, YLK), Tzu Chi University, Hualien, Taiwan; Department of Laboratory Medicine (CCY), Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan; Department of Research (SW), Buddhist Tzu-Chi Hospital, Taipei Branch, Taiwan; and Department of Life Science (SW), Chinese Culture University, Taipei, - - 2014
Growth-differentiation factor (GDF)-15 is a strong predictor of cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). However, the effects of GDF-15 on left ventricular (LV) remodeling have not been clearly elucidated. The aim of this study is to investigate whether GDF-15 will be of benefit in predicting LV remodeling, ...
Conraads Viviane M VM 1Department of Cardiology, Antwerp University Hospital, Edegem, Belgium; University of Antwerp, Antwerp, - - 2014
-Physical activity (PA) predicts cardiovascular mortality in the population at large. Less is known about its prognostic value in chronic heart failure (CHF) patients (pts). -Data from 836 patients with implanted defibrillators without (ICD) or with cardiac resynchronization therapy (CRT-D) enrolled in the Sensitivity of the InSync Sentry OptiVol feature ...
Ribas Nuria N Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Madrid, Spain; Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain. Electronic address: - - 2014
In the general population, heart events occur more often during early morning, on Mondays, and during winter. However, the chronobiology of death in heart failure has not been analyzed. The aim of this study was to determine the circadian, day of the week, and seasonal variability of all-cause mortality in ...
Steg Philippe Gabriel PG Université Paris-Diderot, DHU FIRE; Hôpital Bichat; INSERM U-1148, Paris, France; NHLI, Imperial College, ICMS, Royal Brompton Hospital, London, - - 2014
Percutaneous coronary intervention has revolutionized the management of coronary artery disease (CAD)(1). Its main goals are to improve the quantity and sometimes the quality of life, by reducing mortality and nonfatal outcomes and by improving symptoms. While these goals were clearly achieved when PCI was applied to the treatment of ...
Klein Liviu - - 2014
Sudden cardiac deaths account for 350,000 to 380,000 deaths in the United States annually. Implantable cardioverter-defibrillators have improved sudden death outcomes in patients with heart failure, but only a minority of patients with defibrillators receives appropriate therapy for ventricular arrhythmias. The risk prediction for sudden death and selection of patients ...
Mitchell Jonathan J University of North Carolina, Chapel Hill, NC, - - 2014
Measurement of troponin levels provides the most sensitive and accurate serologic information in evaluating a patient with acute coronary syndrome (ACS); troponin elevations are more sensitive than elevations of creatine kinase-MB (CK-MB). Isolated elevation of troponin levels increases the likelihood of myocardial infarction (MI) or death, whereas isolated elevation of ...
Zheng Bin B Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, - - 2014
Patients with atherosclerotic renal artery stenosis (ARAS) are in substantial risk of cardiovascular adverse events. We investigated whether myocardial infarction patients with ARAS are in additional risk of cardiovascular events. In this retrospective study, 257 patients with type 1 myocardial infarction were enrolled. Median follow-up was 42 months. Composite endpoint ...
Baker Nevin C NC Division of Cardiology, MedStar Washington Hospital Center, Washington, District of - - 2014
A consensus on what constitutes a clinically meaningful periprocedural myocardial infarction (PMI) remains highly debated. We evaluated the accuracy of 2 PMI definitions currently implemented for quality outcome assessment and clinical trial end points. Patients who underwent elective percutaneous coronary intervention with normal baseline troponin-I and creatine kinase-MB were included. ...
Larsen Alf I AI Department of Cardiology, Stavanger University Hospital, Stavanger, Norway; Institute of Medicine, University of Bergen, Bergen, - - 2014
Statin therapy is indicated after ST-segment elevation myocardial infarction (STEMI) to reduce recurrent ischemic events, but approximately 6% of patients with STEMI do not receive a statin prescription at discharge. This substudy aimed to define the clinical outcomes and patient characteristics associated with statin nonprescription after STEMI. We compared clinical, ...
Pen Ally A Department of Medicine (Cardiology and Nuclear Medicine), The University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y - - 2014
We sought to determine the prognostic value of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with prior coronary artery bypass graft (CABG) surgery. PET MPI has recently been shown to provide incremental risk stratification for patients with suspected coronary artery disease (CAD), but the prognostic utility of ...
Kolettis Theofilos M TM Department of Cardiology, University of Ioannina, Cardiovascular Research Institute, Ioannina and Athens, Greece. Electronic address: - - 2014
Ventricular arrhythmogenesis during acute coronary syndromes is a common cause of sudden cardiac death, but the underlying mechanisms remain incompletely understood. Recent evidence indicates an emerging pathophysiologic role of endothelin-1 during myocardial ischaemia and evolving infarction. At the early stages post-coronary occlusion, endothelin-1 enhances sympathetic activation, an effect mediated via ...
Funke-Kaiser Anne A Hamburg University Heart Center, - - 2014
Biomarkers may contribute to risk stratification in coronary heart disease (CHD). We examined whether plasma midregional proadrenomedullin (MR-proADM) concentration at baseline and its change over one year predicts long-term outcomes in stable CHD patients. The LIPID study randomised patients 3-36months after an acute coronary syndrome with total cholesterol 4.0-7.0mmol/L (155-271mg/dL), ...
Hata Yukiko Y Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, - - 2014
A 64-year-old woman was found dead in her home. At autopsy, although relatively fresh bruises were found on her body, no lethal injury was observed in an internal observation. Mild edematous swelling of the right half of the medulla oblongata was observed. There was acute medial medullary infarction (MMI), which ...
Damman Peter P Department of Cardiology, Academic Medical Center - University of Amsterdam, Amsterdam, The - - 2014
No five-year long-term follow-up data is available regarding the prognostic value of GDF-15. Our aim is to evaluate the long-term prognostic value of admission growth-differentiation factor 15 (GDF-15) regarding death or myocardial infarction (MI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). This is a subanalysis from the ICTUS (Invasive ...
Waks Jonathan W JW TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
The relationships between Q waves that appear during the acute phase of ST-elevation myocardial infarction (STEMI), clinical characteristics, ST-segment resolution (STRes), and clopidogrel therapy in patients treated with fibrinolysis are not well described. We hypothesized that Q waves would be associated with less successful reperfusion and increased cardiovascular events. In ...
Piccolo Raffaele R Department of Advanced Biomedical Sciences, Federico II University, Naples, - - 2014
Aims: In recent years, intracoronary bolus abciximab has emerged as an alternative to the standard intravenous route in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The aim of the current study was to perform an individual patient-level pooled analysis of randomised trials, comparing intracoronary versus ...
Rydén Linda L Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Internal Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: - - 2014
Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) is associated with early mortality. Its impact on the risk of myocardial infarction (MI) over time and long-term mortality has not been well described. We performed a nationwide population-based cohort study in 27,929 patients who underwent a first isolated CABG ...
O'Sullivan Crochan J CJ Department of Cardiology, Bern University Hospital, Bern, - - 2014
Aims: We aimed to assess the impact of B-type natriuretic peptide (BNP) on short-term outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). Methods and results: Of 500 consecutive patients with severe aortic stenosis undergoing TAVI at our institution, we studied 340 patients who had a BNP assessment prior to ...
Goldberger Jeffrey J JJ Center for Cardiovascular Innovation and the Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address: - - 2014
To provide a meta-analysis to estimate the performance of 12 commonly reported risk stratification tests as predictors of arrhythmic events in patients with NIDCM. Multiple techniques have been assessed as predictors of death due to ventricular tachyarrhythmias/sudden death in patients with non-ischemic dilated cardiomyopathy (NIDCM). Forty-five studies enrolling 6088 patients ...
Grundeken Maik J MJ Department of Cardiology, Academic Medical Center-University of Amsterdam, , Amsterdam, The - - 2014
We evaluated differences in clinical outcomes between patients who underwent final kissing balloon inflation (FKBI) and patients who did not undergo FKBI in bifurcation treatment using the Tryton Side Branch Stent (Tryton Medical, Durham, North Carolina, USA). Clinical outcomes were defined as target vessel failure (composite of cardiac death, any ...
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