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Choi Hong Sang - - 2012
BACKGROUND: The aim of this study was to investigate a useful cardiac biomarker for predicting echocardiographic right ventricular (RV) dysfunction in patients with acute pulmonary embolism (APE). METHODS: A total of 84 patients with APE were divided into two groups: patients with RV dysfunction (group I, n=51, 61.8±15.1 years) versus ...
Uhm Jae-Sun - - 2012
Background: Radiofrequency catheter ablation (RFCA) for intraatrial reentrant tachycardia (IART) in congenital heart disease (CHD) remains difficult. Methods: Thirty-four consecutive adult patients (age, 37.6 ± 12.8 years; male, 21) with previously repaired CHD and IART underwent an electrophysiological study and RFCA. CHD included atrial septal defect (ASD, n = 14), ...
Azab Basem - - 2012
The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker of major adverse cardiac events (MACEs) in both acute coronary syndromes and stable coronary artery disease. The use of NLR as a predictive tool for MACEs among diabetic patients has not been elucidated. An observational study included 338 diabetic patients followed at ...
Kagawa Eisuke - - 2012
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) and percutaneous coronary intervention (PCI) may be useful in cardiopulmonary resuscitation (CPR). However, little is known about the combination of ECMO and intra-arrest PCI. This study investigated the efficacy of rapid-response ECMO and intra-arrest PCI in cardiac arrest patients who were unresponsive to conventional CPR ...
Layland Jamie J - - 2012
BACKGROUND: This study was designed to assess whether measurement of the index of microvascular resistance (IMR) could help prospectively identify patients who develop periprocedural myocardial infarction (PPMI). METHODS AND RESULTS: IMR was measured in 54 patients before and following percutaneous coronary intervention (PCI) in a culprit vessel with a PressureWire ...
Feuchtner Gudrun Maria - - 2012
To determine whether evaluation of resting myocardial CT perfusion (CTP) from coronary CT angiography (CTA) datasets in patients presenting with chest pain (CP) to the emergency department (ED), might have added value to coronary CTA. 76 Patients (age 54.9 y±13; 32 (42%) women) presenting with CP to the ED underwent ...
Komajda Michel - - 2012
AIMS: A post-hoc analysis of the SHIFT trial was performed to explore whether ivabradine is beneficial in patients with systolic heart failure, in sinus rhythm, with resting heart rate ≥70 b.p.m., and whose guideline-recommended background therapy includes a mineralocorticoid receptor antagonist (MRA). METHODS AND RESULTS: The effect of ivabradine on ...
Mueller Enkhtuyaa - - 2012
Bivalirudin (BIV) is superior to a heparin/glycoprotein IIb/IIIa receptor inhibitor (GPI) strategy with respect to net adverse cardiovascular events for ST-segment elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI), albeit with an increased risk of acute stent thrombosis. We hypothesized that a 2-hour BIV infusion after PCI (BIV + 2) ...
Scandura Salvatore - - 2012
BACKGROUND: Successful mitral valve surgical repair, decreasing volume overload, has been shown to provide reverse left ventricular (LV) and/or left atrial remodeling in most patients. Percutaneous mitral valve repair with the MitraClip system (Abbott, Abbott Park, IL) has been associated with favorable clinical outcomes in patients with mitral regurgitation at ...
Healey Jeff S - - 2012
Cardiac resynchronization (CRT) prolongs survival in patients with systolic heart failure and QRS prolongation. However, most trials excluded patients with permanent atrial fibrillation. The Resynchronization for Ambulatory Heart Failure Trial (RAFT) randomized patients to an implantable cardioverter defibrillator (ICD) or ICD+CRT, stratified by the presence of permanent atrial fibrillation. Patients ...
Sargento-Freitas Joao - - 2012
Background/Aims: Endovascular recanalization therapies are an increasingly used strategy for acute cerebral ischemia with heterogeneous clinical outcomes. We aimed to determine the impact of previous medication on ischemic stroke following intra-arterial revascularization therapy. Methods: Consecutive patients receiving intra-arterial reperfusion therapy after an acute intracranial occlusion were analyzed. Premorbid use of ...
Toyama Takuji - - 2012
Objectives: Hypertension impairs coronary endothelial cell function, coronary microvascular function and the coronary flow (CF) reserve (CFR). Angiotensin II receptor blockers (ARBs) have been reported to possibly improve coronary endothelial function and coronary microvascular function. The purpose of this study was to determine whether treatment with the ARB olmesartan was ...
Ternacle Julien - - 2012
AIMS: Global longitudinal strain (GLS) seems accurate for detecting subclinical myocardial dysfunction, and may therefore be used to improve risk stratification for cardiac surgery. METHODS AND RESULTS: Longitudinal strain (by two-dimensional speckle tracking) was computed in 425 patients [mean age 67 ± 13 years, 69% male, left ventricular ejection fraction ...
Monte Ines - - 2012
BACKGROUND: Iron-mediated cardiomyopathy is the leading cause of death in patients with thalassemia major (TM). The identification of subclinical cardiac involvement in the early phases of the disease is important to optimize therapeutic strategies. The aim of this study was to identify early markers of cardiac dysfunction through new parameters ...
John Roy M - - 2012
Implantable cardioverter-defibrillators (ICDs) are highly effective in reducing mortality related to ventricular arrhythmias. However, there is considerable morbidity associated with their use, mostly related to ICD shocks. In addition, the occurrence of arrhythmias and ICD shocks in patients with heart failure is associated with an adverse prognosis. Strategies to reduce ...
Andrie Rene P - - 2012
ABSTRACT: INTRODUCTION: Cardiogenic shock (CS) remains the leading cause of death in patients hospitalized for myocardial infarction (MI). Systemic inflammation with inappropriate vasodilatation is observed in many patients with CS and may contribute to an excess mortality rate. The purpose of this study was to determine the predictive role of ...
Ye Zhong - - 2012
BACKGROUND: Conflicting results exist now on the sustained effects of intracoronary bone marrow-derived mononuclear cells (BMMNCs) infusion in patients with acute myocardial infarction (AMI). METHODS: Systematical literature search of PubMed, ISI Web of Science, and Cochrane databases was conducted. We included the randomised controlled trials with at least 12-month follow-up ...
Salgado Diamantino Ribeiro - - 2012
Context: The renin-angiotensin system is activated in patients with acute severe heart failure, and increased levels of angiotensin II could contribute to microcirculatory defects in these patients. Objective: To evaluate the microcirculatory effects of angiotensin II antagonists in critically ill patients with severe heart failure. Methods: After Ethics Committee approval ...
Man Jonathan - - 2012
Atrial fibrillation (AF) worsens outcome in patients with systolic heart failure and the presence of heart failure (HF) predicts a 5- to 6-fold increase in risk of AF. In addition to loss of atrial systole, AF may contribute to left ventricular (LV) systolic dysfunction due a rapid ventricular rate, irregularity ...
Lok Dirk J - - 2012
BACKGROUND: Galectin-3 (Gal-3) is a recently discovered marker for myocardial fibrosis and elevated levels are associated with an impaired outcome after short-term follow-up in heart failure (HF) patients. However, whether Gal-3 is related to cardiac remodeling and outcome after long-term follow-up is unknown. Therefore, we determined the utility of Gal-3 ...
Lotfy Wael - - 2012
Pediatric pacemaker (PM) implants comprise less than 1 % of all PM implants. This study aimed to investigate permanent cardiac pacing among the pediatric population, identifying different indications and complications of pediatric cardiac pacing, especially focusing on the effect of the pacing sites, the PM lead type, and the indications for ...
Betensky Brian P - - 2012
PURPOSE: Sinus rhythm (SR) electrocardiogram (ECG) features in patients with nonischemic cardiomyopathy (NICM) and ventricular tachycardia (VT) have been described. ECG characteristics that distinguish nonischemic VT substrate from prior myocardial infarction (MI) have yet to be determined. We aimed to identify ECG differences between patients with basal-inferolateral scar due to ...
Bradfield Jason S - - 2012
PURPOSE OF REVIEW: Implantable cardioverter-defibrillator (ICD) implantation is the standard of care for secondary prevention in patients with previous cardiac arrest and for primary prevention in appropriately selected patients with cardiomyopathy. However, ICD therapies and the arrhythmias that trigger these therapies cause decreased quality of life as well as increased ...
Yang Jeong Hoon - - 2012
Objectives: Bifurcation angle has emerged as a predictor of outcome after percutaneous coronary intervention (PCI) for bifurcation lesions. We investigated the impact of bifurcation angle on clinical outcomes in patients undergoing bifurcation lesion PCI. Methods: Consecutive patients who received PCI for bifurcation lesions were enrolled from 16 centers in Korea ...
Stammet Pascal - - 2012
OBJECTIVE:: Prediction of clinical outcome after cardiac arrest is clinically important. While the potential of circulating microRNAs as biomarkers of acute coronary syndromes is an active field of investigation, it is unknown whether microRNAs are associated with outcome in cardiac arrest patients. DESIGN:: Prospective, single-center proof-of-concept study. SETTING:: Eighteen-bed adult ...
Koutalas Emmanuel - - 2012
Non ischemic dilated cardiomyopathy poses a significant risk of malignant ventricular arrhythmias and subsequent sudden cardiac death. The pathologic and electrophysiological substrate implicated to arrhythmogenesis has been quite adequately defined over the last decades and multiple forms of myocardial fibrosis - diffuse, patchy or gross scarring - are being studied ...
Fernandes Juliano L - - 2012
Thalassemia major (TM) patients have altered ventricular volumes and ejection fraction compared to normals, although evidence for these findings stem from restricted patient groups and has never been reproduced. We sought to evaluate cardiac parameters by cardiovascular magnetic resonance (CMR) in a group of young TM patients not covered by ...
Hansch Andreas - - 2012
BACKGROUND: The aim of this study was to determine peak ventricular transit time (PVTT) using cardiac magnetic resonance (cMRI) imaging with first-pass perfusion and to evaluate PVTT as a potential new predictor of cardiac failure. METHODS AND RESULTS: cMRI was performed on 150 patients. The PVTT between the right and ...
Venkataraman Rajesh R Division of Cardiovascular Disease, University of Alabama at Birmingham, AL, USA. - - 2012
We previously reported that ranolazine improves exercise myocardial perfusion. Ranolazine ameliorates myocardial ischemia by augmenting myocardial blood flow; likely by a reduction in the extravascular compression of small vessels. We hypothesized that ranolazine could improve left ventricular (LV) dyssynchrony as assessed by phase analysis of gated single photon emission computed ...
Hou Zhi-Hui - - 2012
RATIONALE AND OBJECTIVES: To document the prevalence of coronary artery disease (CAD) and major adverse cardiac events (MACE) in patients younger than 45 years of age with intermediate pretest likelihood of CAD, and to determine whether coronary computed tomography angiography (cCTA) is useful for risk stratification of this cohort. MATERIALS ...
Vassileva Christina M - - 2012
BACKGROUND: Within the field of cardiac surgery, several strategies have been adopted in an effort to address contributors to increasing health care costs. Limited data are available on cost analysis within the field of mitral valve surgery. The purpose of our investigation was to analyze cost differences between mitral valve ...
Khan Razi - - 2012
Myocardial fibrosis (MF) is a common pathophysiologic endpoint in non-ischemic cardiomyopathy and may be identified by Late Gadolinium Enhancement (LGE) MRI. While associated with future cardiovascular events in Hypertrophic Cardiomyopathy (HCM) and Dilated Cardiomyopathy (DCM) the influence of MF on interim quality of life (QOL) has not been explored. In ...
Elbasan Zafer - - 2012
Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 840 patients with STEMI who underwent primary percutaneous coronary ...
Sbrana Francesco - - 2013
Although high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with cardiovascular risk, patients with elevated HDL-C also develop coronary artery disease (CAD) and cardiac events. We aimed to draw the clinical profile of CAD patients with elevated HDL-C and to assess the prognostic impact of elevated HDL-C. We prospectively examined ...
Chen Chien-Cheng CC Department of Cardiology, Show Chwan Memorial Hospital, Changhua, - - 2012
In (201)Tl SPECT myocardial perfusion imaging (MPI) data are acquired shortly after the stress injection to assess early post-stress left ventricle (LV) function. The purpose of this study was to use (201)Tl SPECT MPI to investigate whether stress-induced myocardial ischemia is associated with LV mechanical dyssynchrony. Enrolled in the study ...
Manabe Susumu S Department of Cardiovascular Surgery, Teikyo University Hospital, Tokyo, Japan. - - 2013
A hyperkinetic heart has been suggested as a risk factor for systolic anterior motion (SAM) after mitral valve repair, but the influence of preoperative left ventricular (LV) function on the development of SAM has not been elucidated. Transthoracic echocardiographic data were retrospectively reviewed in 441 patients who underwent mitral valve ...
Shin Dong Il - - 2012
Background: The rate of percutaneous coronary intervention (PCI) due to the development of significant atherosclerosis and the cardiac mortality rate in Korean patients with vasospastic angina (VA) was estimated. Methods and Results: A total of 831 patients with VA from 8 centers were registered in the Vasospastic Angina in the Catholic Medical ...
Morris Daniel A - - 2012
BACKGROUND: -The aim of this study was to investigate in patients with heart failure with normal left ventricular (LV) ejection fraction (HFNEF) the myocardial systolic and diastolic performance of the left ventricle (LV) through novel LV myocardial indices, which assess the systolic and diastolic function of the whole myocardium of ...
Weiner M M - - 2012
BACKGROUND: /st>Increased left ventricular mass (LVM) is a well-recognized predictor of cardiovascular morbidity and mortality in epidemiological studies, but its impact on mortality after cardiac surgery is poorly defined. We hypothesized that patients with increased LVM index (LVMI) were more likely to have greater 30 day and 1 yr mortality. ...
Norris Davena M - - 2012
Periprocedural myocardial infarction (PMI) is a common complication associated with percutaneous coronary intervention (PCI), occurring in approximately 15-20% of patients undergoing the procedure. The established diagnostic criteria for PMI is an increase in cardiac biomarkers, specifically creatine kinase-MB levels of greater than 3 times the upper limit of normal. As ...
Delewi Ronak - - 2012
CONTEXT: Numerous randomized controlled studies assessing intracoronary bone marrow cell therapy (BMC) after acute myocardial infarction (AMI) have been performed. OBJECTIVE: To systematically review the effect of autologous BMC therapy on left ventricular function by performing an up to date meta-analysis of randomized controlled trials (RCTs) including long-term follow-up. DATA ...
Moscariello Antonio - - 2012
To assess the efficacy of coronary computed tomographic (CT) angiography for therapeutic decision making in patients with high likelihood of coronary artery disease (CAD)-specifically the ability of coronary CT angiography to help differentiate patients without and patients with a need for revascularization and determine the appropriate revascularization procedure. The study ...
Yeung Chun-Yip CY Department of Medicine, Division of Endocrinology, The University of Hong Kong, Hong Kong, - - 2012
Diabetes mellitus (DM) is a well-established risk factor for coronary artery disease. Nonetheless, it remains unclear whether DM contributes to sudden cardiac death in patients who survive myocardial infarction (MI). The objective of this study was to compare the incidence of sudden cardiac death post-MI in diabetic and nondiabetic patients ...
Ståhlberg Marcus - - 2012
Heart failure is now considered an epidemic. In patients with heart failure, electrical and mechanical dyssynchrony, evident primarily as QRS prolongation on the surface electrocardiogram, is associated with detrimental effects on the CV system at several levels. In the past 10 years, studies have demonstrated that by stimulating both cardiac ...
Valk Suzanne D A - - 2012
PURPOSE: Contemporary outcome data of catheter ablation for outflow tract tachycardia (OTT) and ventricular premature beats (VPBs) are rare. The aim of this study was to describe the clinical characteristics, the acute procedure success rate, and the long-term survival of patients who underwent an ablation procedure for OTT or VPBs. ...
Sonoda Hiroo - - 2012
Background: Diagnosis of left ventricular (LV) diastolic dysfunction by blood testing is expedient in the clinical setting. Methods and Results: In 98 patients with LV ejection fraction ≥50% who underwent cardiac catheterization for evaluation of coronary artery disease, LV pressure (LVP) was measured using a catheter-tipped micromanometer. A time constant, τ, of ...
Son Jang-Won - - 2012
Background: The current study was designed to investigate the correlation between the left ventricular (LV) vortex flow pattern and LV apical thrombus formation in patients with acute anterior wall myocardial infarction (MI). Methods and Results: Fifty-seven patients with acute anterior wall MI were enrolled in this study. Eighteen patients with apical thrombus ...
Gaibazzi Nicola N Parma University Hospital, Via Gramsci, 14, 43124 Parma, Italy. - - 2012
The addition of myocardial perfusion (MP) imaging during dipyridamole real-time contrast echocardiography improves the sensitivity to detect coronary artery disease, but its prognostic value to predict hard cardiac events in large numbers of patients with known or suspected coronary artery disease remains unknown. We studied 1252 patients with the use ...
Kikkert Wj - - 2012
OBJECTIVES: The objective of the current analysis is to determine the effects on mortality of thrombus aspiration during primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI) compared with conventional PCI. BACKGROUND: Adjunctive thrombus aspiration in STEMI improves markers of myocardial reperfusion but evidence for improved survival is limited ...
Maggioni Aldo Pietro - - 2012
Dual antiplatelet therapy is the recommended treatment for all patients with an acute coronary syndrome treated or not with an invasive procedure(1-4). Several trials testing clopidogrel(5-7) or new antiplatelet agents(8,9) clearly showed that the addition of a thyenopiridine to aspirin is associated with a significant improvement of patients' outcomes. Further, ...
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