Search Results
Results 1 - 50 of 1951
1 2 3 4 5 6 7 8 9 10 >
Ko Sung Min SM 1 Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul, 143-729, - - 2014
OBJECTIVE. The purpose of this study was to assess the diagnostic performance of stress perfusion dual-energy CT (DECT) and its incremental value when used with coronary CT angiography (CTA) for identifying hemodynamically significant coronary artery disease. SUBJECTS AND METHODS. One hundred patients with suspected or known coronary artery disease without ...
Barone-Rochette Gilles G Department of Cardiology, CHU Grenoble, University Hospital, BP 217, 38043, Grenoble Cedex 09, France, - - 2014
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope protocols. So far, no study has compared dual-isotope high-speed MPI to invasive coronary angiography (ICA) in ...
Yao Tianbao T Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Cardiology, Shanghai, China ; - - 2014
Aims: To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate the underlying mechanisms involved. Results: The endogenous VDR expression was detected in the mouse heart, and myocardial ischemia/reperfusion (MI/R) upregulated VDR expression. Activation of VDR by natural and synthetic agonists reduced myocardial infarct ...
Galyfos George G First Department of Propaedeutic Surgery, University of Athens Medical School, Hippocration Hospital, Athens, - - 2014
Our aim was to examine the predictive value of preoperative stress echocardiography regarding early myocardial ischemia and late cardiac events after carotid endarterectomy (CEA). Patients with coronary artery disease undergoing CEA were prospectively included in this study. All patients (n = 162) were classified into low, medium, and high cardiac risk group, ...
Veress Alexander I - - 2014
This paper describes the process in which complex lesion geometries (specified by computer generated perfusion defects) are incorporated in the description of nonlinear FE mechanical models used for specifying the motion of the left ventricle (LV) in the 4D XCAT phantom to simulate gated cardiac image data. An image interrogation ...
Araujo Ana Carla Pereira de AC Universidade Federal de Sergipe, Aracaju, SE, - - 2014
Background: Studies have demonstrated the diagnostic accuracy and prognostic value of physical stress echocardiography in coronary artery disease. However, the prediction of mortality and major cardiac events in patients with exercise test positive for myocardial ischemia is limited. Objective: To evaluate the effectiveness of physical stress echocardiography in the prediction ...
Czibik Gabor G INSERM U955, Equipe 8, Faculty of Medicine, DHU A-TVB, Hôpital Henri Mondor, APHP, Creteil, University of Paris-Est, 3rd Floor, room 3006, Paris, France, - - 2014
Activation of heme oxygenase-1 (HO-1), a heme-degrading enzyme responsive to a wide range of cellular stress, is traditionally considered to convey adaptive responses to oxidative stress, inflammation and vasoconstriction. These diversified effects are achieved through the degradation of heme to carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin ...
Mak I Tong IT aDepartment of Biochemistry & Molecular Medicine, and bDepartment of Medicine, The George Washington University, Washington, DC 20037, USA, and cDivision of Cardiology, Children's National Medical Center, Washington, DC 20010 - - 2014
To determine whether the EGFR tyrosine kinase inhibitor, erlotinib may cause hypomagnesemia, inflammation and cardiac stress, erlotinib was administered to rats (10 mg/kg/day) for 9 weeks. Plasma magnesium decreased progressively between 3-9 weeks (-9 to -26%). Modest increases in plasma substance P (SP) occurred at 3 (+27%) and 9 (+25%) ...
Mojsejenko Dimitri D Department of Mechanical Engineering, University of Kentucky, 269 Ralph G. Anderson Building, Lexington, KY, 40506-0503, - - 2014
Myocardial infarction (MI) triggers a series of maladaptive events that lead to structural and functional changes in the left ventricle. It is crucial to better understand the progression of adverse remodeling, in order to develop effective treatment. In addition, being able to assess changes in vivo would be a powerful ...
Pagliaro P P Department of Clinical and Biological Sciences University of Torino, 10043 Orbassano (TO), - - 2014
The morbidity and mortality from coronary artery disease (CAD) remain significant worldwide. The treatment for acute myocardial infarction has improved over the past decades, including early reperfusion of culprit coronary arteries. Although it is mandatory to reperfond the ischemic territory as soon as possible, paradoxically this leads to additional myocardial ...
Malfitano Christiane - - 2014
BackgroundPrevious research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), ...
Sunderland John J JJ Department of Radiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA, - - 2014
Recent technological improvements to PET imaging equipment combined with the availability of software optimized to calculate regional myocardial blood flow (MBF) and myocardial flow reserve (MFR) create a paradigm shifting opportunity to provide new clinically relevant quantitative information to cardiologists. However, clinical interpretation of the MBF and MFR is entirely ...
Jhun Choon-Sik CS Division of Artificial Organs, Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA, 17033, USA, - - 2014
Left ventricular assist device (LVAD) support unloads left ventricular (LV) pressure and volume and decreases wall stress. This study investigated the effect of systematic LVAD unloading on the 3-dimensional myocardial wall stress by employing finite element models containing layered fiber structure, active contractility, and passive stiffness. The HeartMate II(®) (Thoratec, ...
Kato Ryuji R Osaka University of Pharmaceutical - - 2014
The prevalence of sleep apnea is much higher in patients with heart failure, and intermittent hypoxia (IH) relevant to sleep apnea might induce left ventricular (LV) remodeling. The aim of this study was to investigate the effect of repetitive hypoxic stress on failing heart and to evaluate the antioxidant effect ...
He Qing Q Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, - - 2014
-Liver-X-receptors, LXRα (NR1H3) and LXRβ (NR1H2), encode two different but highly homologous isoforms of transcription factors belonging to the nuclear receptor superfamily. Whether LXRα and LXRβ subtypes have discrete roles in the regulation of cardiac physiology/pathology is unknown. We determine the role of each LXR subtype in myocardial ischemia/reperfusion (MI/R) ...
He Yun-Yun YY *Chinese PLA General Hospital, Beijing, China; †School of Medicine, Nankai University, Tianjin, China; and ‡Beijing Institute of Pharmacology and Toxicology, Beijing, - - 2014
: PP1-12, a new protein phosphatase-1 inhibitor, is designed and synthesized to modulate the endoplasmic reticulum (ER) stress apoptotic pathway, which is involved in various cardiovascular diseases. In this study, we examined the effect of PP1-12 on ventricular remodeling and heart function after myocardial infarction. Rats that survived within 24 ...
Schneeweis Christopher - - 2014
Dobutamine stress cardiovascular magnetic resonance (DS-CMR) has been established for the detection of coronary artery disease (CAD). The novel technique feature tracking (FT) analyses left ventricular circumferential strain (Ecc) thus offering detailed information about myocardial deformation. The purpose of this study was to evaluate FT based Ecc for the detection ...
Collste O O Departments of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. Electronic address: - - 2014
Our objective was to investigate whether dobutamine stress echocardiography (DSE) could induce abnormal cardiac function in Takotsubo stress cardiomyopathy (TSC) patients in a stable condition after the acute attack. This study is a case-control study and a sub-study of the Stockholm Myocardial Infarction with Normal Coronaries (SMINC) study. Twenty-two patients ...
Huang Wen-Sheng WS Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, - - 2014
Previous studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT myocardial perfusion imaging (MPI). The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of angiographic coronary artery disease (CAD). The MPI images of 144 patients ...
Pahlm Ulrika S - - 2014
Left ventricular function is altered during and after AMI. Regional function can be determined by cardiac magnetic resonance (CMR) wall thickening, and velocity encoded (VE) strain analysis. The aims of this study were to investigate how regional myocardial wall function, assessed by CMR VE-strain and regional wall thickening, changes after ...
Wittekind Samuel G SG Department of Pediatrics, - - 2014
Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is an acquired form of left ventricular systolic dysfunction seen in the setting of physiologic stress and the absence of coronary artery disease. It is thought to be caused by excessive sympathetic stimulation. It is well described in the adult literature associated with ...
Linde Jesper James JJ Department of Cardiology, Hvidovre Hospital, University of Copenhagen, Kettegård alle 30, 2650, Hvidovre, Denmark, - - 2014
To assess the relationship between epicardial coronary artery stenosis severity and the corresponding regional transmural perfusion at rest and during adenosine stress, using multidetector computed tomography (MDCT). We evaluated the relationship between the severity of coronary artery diameter stenosis assessed by MDCT angiography and semi-quantitative myocardial MDCT perfusion in 200 ...
Pislaru Cristina C Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, - - 2014
The mechanism of flow propagation during diastole in the left ventricle (LV) has been well described. Little is known about the associated waves propagating along the heart walls. These waves may have a mechanism similar to pulse wave propagation in arteries. The major goal of the study was to evaluate ...
Gimelli Alessia A Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy - - 2014
The aim of this study was to evaluate the possible impact of stress-induced left ventricular (LV) diastolic dysfunction at cadmium-zinc-telluride (CZT) imaging, on the detection of significant coronary artery disease (CAD). Four hundred and twenty-five consecutive patients underwent myocardial perfusion imaging at rest and after stress with a low-dose CZT ...
Jayasinghe R R Cardiology Department, Gold Coast University Hospital, Southport, Queensland, Australia; School of Medicine, Griffith University, Southport, Queensland, - - 2014
Copeptin is a non-specific marker of an endogenous stress response. A dual biomarker marker approach involving the simultaneous use of troponin and copeptin assays may assist early exclusion of acute coronary syndrome in Australian emergency departments. The utility and limitations of this approach are discussed.
Ramadan Ronnie R From the Department of Medicine (R.R., V.V., A.Q.), Division of Cardiology, and Departments of Radiology (F.E.) and Psychiatry, (J.D.B.), Emory University School of Medicine, Atlanta, Georgia; Department of Epidemiology (V.V.), Emory University Rollins School of Public Health, Atlanta, Georgia; Department of Epidemiology (D.S.S.), University of Florida School of Public Health, Gainesville, Florida; and Department of Cardiology (P.R.), Mazankowski Alberta Heart Institute, Alberta, - - 2014
Mental stress-induced (MSIMI) or physical stress-induced (PSIMI) myocardial ischemia portends a worse prognosis in patients with coronary artery disease (CAD). Vitamin D insufficiency is associated with adverse cardiovascular outcomes, but its relationship to myocardial ischemia remains unclear. We hypothesized that vitamin D insufficiency will be associated with a higher prevalence ...
Hwang Hui-Jeong HJ Department of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, - - 2014
The purpose of this study was to evaluate whether performing an assessment of myocardial deformation using speckle tracking imaging during the recovery period after dobutamine stress echocardiography (DSE) allows detection of significant coronary artery disease (CAD) in patients with chest discomfort. DSE and coronary angiography were performed in 44 patients ...
Park Sung-Ji - - 2014
Microvascular angina (MVA) is characterized by anginal chest pain, an abnormal stress test, and normal coronary arteries on coronary angiography. Although the exact pathogenesis remains unclear, endothelial dysfunction is a contributing factor. To date, there exists no specific therapy for this disease. Phosphodiesterase-5 inhibitor improves the endothelial function and subsequently ...
Singh Harmandeep H Department of Nuclear Medicine, All India Institute of Medical Sciences, B-54, South Extension Part-1, New Delhi, 110049, - - 2014
The relationship between perfusion pattern and stress-induced changes in left ventricular mechanical dyssynchrony (LVMD) on stress-rest thallium-201-gated SPECT myocardial perfusion imaging (Tl-201 SPECT MPI) is not clear. The aim of the study is to assess the relation of perfusion pattern with stress-induced changes in LVMD on Tl-201 MPI. Data of ...
Brooks Alan C AC Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, - - 2014
Ischemic preconditioning (PC) is an adaptive response to transient myocardial ischemia that protects the heart from subsequent ischemia/reperfusion (I/R) injury. However, the mechanisms underlying its cardioprotective effects remain unclear. Myocardium of adult male C57/BL6 mice, preconditioned by 6cycles of 4minute coronary occlusion and reperfusion, showed nuclear translocation of ATF3, and ...
Russo A A Department of Anesthesiology and Intensive Care Medicine, and Institute of Biochemistry and Clinical Biochemistry, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy. - - 2014
Cardiovascular changes during laparoscopic surgery have been described in several studies. Pneumoperitoneum effects on cardiac performance instead have not been much investigated and are less known. The carbon dioxide insufflation necessary in order to perform laparoscopic procedures represents a higher force against which the myocardial fibers must shorten during ventricular ...
Patel Kunal K 0000-0002-0087-634X Department of Cardiovascular Services, Trinitas Regional Medical Center, Seton Hall University, 225 Williamson Street, Elizabeth, NJ 07202, - - 2014
Wellens' syndrome, also known as LAD coronary T-wave inversion syndrome, is a characteristic ECG pattern that highly suggests critical stenosis of the proximal left anterior descending (LAD) coronary artery. 75% of patients with this finding go on to develop acute anterior wall myocardial infarction within one week unless prevented by ...
Cho Kyoung-Im KI Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan 602702, Korea. - - 2014
Increased atrial oxidative stress has an important role in inducing and maintaining atrial fibrillation (AF), and the activation of the small GTPase Rac1 contributes to the oxidative stress. We investigated the relationship of Rac1, atrial endothelial thromboprotective markers and AF inducibility and if simvastatin has a potential beneficial effect on ...
Yang Mei M Department of Critical Care Medicine, the Third Hospital of Jinan, Jinan, People's Republic of - - 2014
The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-α induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. ...
Krag Aleksander A Department of Gastroenterology, Odense University Hospital, Odense, Denmark; Gastro Unit, Medical Division, Hvidovre Hospital, University of Copenhagen, Copenhagen, - - 2014
Cardiac dysfunction in patients with early cirrhosis is debated. We investigated potential cardiac dysfunction by assessing left ventricular systolic performance during a dobutamine stress test in patients with early cirrhosis. Nineteen patients with Child A and B cirrhosis (9 with non-alcoholic cirrhosis) and 7 matched controls were included. We used ...
Mahmod Masliza M University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK. - - 2014
Myocardial T1 relaxation times have been reported to be markedly abnormal in diverse myocardial pathologies, ascribed to interstitial changes, evaluated by T1 mapping and calculation of extracellular volume (ECV). T1 mapping is sensitive to myocardial water content of both intra- and extracellular in origin, but the effect of intravascular compartment ...
István Kristóf - - 2012
Cardiac fibromas are benign conditions; however, their location and size may cause ventricular arrhythmias and sudden cardiac death. We report a case of a 68-year-old female who died suddenly. Postmortem investigation detected a huge cardiac fibroma in the pars muscularis of the interventricular septum, occupying almost the entire muscular septum, ...
Bayramo─člu Zehra - - 2012
Myxoma is benign tumor of the heart. It is mostly located in the left atrium and revascularized by the left and right coronary artery in 30% to 40% of cases. Symptoms of these neovascularized cardiac myxomas are typically quite variable, from obstruction of mitral valve to coronary embolism resulting in ...
Wey Aaron C - - 2012
Cardiac neoplasia is relatively uncommon in canine patients, with the most common neoplasms including right atrial hemangiosarcoma and paragangliomas occurring at the heart base (i.e. chemodectomas or aortic body tumors). Intracardiac paragangliomas are rare neoplasms in humans and have seldom been documented in the veterinary literature. This report describes the ...
Haydin Sertac - - 2012
Abstract  Cardiac rhabdomyoma is a benign tumor of the heart in childhood and can be associated with life-threatening arrhythmia. In this report, we present the case of a 2-year-old male with right ventricular rhabdomyoma, who was admitted with syncope that was associated with episodes of sustained ventricular tachycardia. The patient ...
Garcia-Ptacek Sara - - 2012
BackgroundMyxomas are rare cardiac tumors which often present with stroke caused by tumorous or thrombotic emboli. Treatment with intravenous recombinant tissue plasminogen activator (rtPA) and intra-arterial thrombolysis has been described previously but mechanical thrombectomy has not yet been reported, and treatment of myxoma-related ischemic stroke remains a clinical and technical ...
Ren Man-Yi - - 2012
The pathophysiological basis of heart failure is cardiac remodeling, a process that comprises structural and functional changes including cardiomyocyte proliferation, hypertrophy, necrosis, apoptosis, autophagy, interstitial fibrosis, contractile dysfunction and ventricular dilatation. Accumulating evidence demonstrate that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is involved in the process by binding ...
Jang Woo-Youl - - 2012
Introduction. The incidence of venous infarction after surgical resection of meningioma is low, but its occurrence can necessitate additional surgical procedures and long hospital stay. In this study, we evaluated variables associated with venous infarction after meningioma surgery. Methods. Among 825 patients with intracranial meningiomas who underwent microsurgical resection between ...
Navarini Susanne - - 2012
Cardiac fibromas are extremely rare in the general pediatric population and may present with a wide spectrum of clinical signs, including life-threatening arrhythmias and sudden death. We report a 14-month-old boy who presented with failure to thrive as the only symptom. Echocardiography showed a large cardiac fibroma in the right ...
Horovitz Alice - - 2012
This report describes the case of a 6-month-old girl with a large cardiac fibroma in the right ventricle. Ventricular tachycardia associated with the fibroma was successfully treated with amiodarone. At the age of 3 years, surgical resection was indicated because of right ventricular outflow tract obstruction caused by progression of ...
Sogawa Masakazu - - 2012
An asymptomatic 73-year-old man underwent resection of a cardiac tumor arising from the right ventricular outflow tract, and reconstruction of the right ventricular outflow tract using an expanded polytetrafluoroethylene sheet. Histological examination revealed a cavernous-capillary type cardiac hemangioma, which is a very rare cardiac tumor.
Sato Teruki - - 2012
We report a case of a giant right atrial myxoma mimicking the right ventricular tumor. The 75-year-old patient underwent cardiac surgery, and the tumor was excised along with the stalk. Tricuspid valve annuloplasty was performed before closure of the right atriotomy. The tumor may have caused intraventricular stenosis, hepatic dysfunction, ...
Demers Gerard - - 2012
Paragangliomas, extra-adrenal pheochromocytomas, are rare and classically associated with sustained or paroxysmal hypertension, headache, perspiration, palpitations, and anxiety. A 49-year-old male, parachute instructor, likely developed a hypertensive emergency when deploying his parachute leading to a myocardial infarction. A para-aortic tumor was incidentally discovered during the patient's emergency department work-up and ...
Banfi Carlo - - 2012
Pheochromocytoma is a catecholamine-secreting tumor associated with clinical presentations ranging from paroxysmal hypertension to intractable cardiogenic shock. We report the use of central extracorporeal life support (ECLS) in a young woman admitted to the intensive care unit with cardiogenic shock. Her medical history included neurofibromatosis type I and pheochromocytoma. ECLS ...
Melo Isabel S - - 2012
A case of ventricular septal tumor diagnosed in 7-month-old boy is reported. An echocardiogram was performed for investigation of a heart murmur in an otherwise healthy infant. He remained asymptomatic, and the tumor had a very slow growth. When the boy was 9 years old, partial surgical excision was performed for ...
1 2 3 4 5 6 7 8 9 10 >