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Mirensky Tamar L - - 2008
Surgical correction of congenital heart defects often requires the use of valves, patches, or conduits to establish anatomic continuity. Homografts, xenografts, or mechanical prosthetic devices are frequently implanted during these surgical procedures. These grafts however lack growth potential, are associated with increased risk of thrombosis and infection and have limited ...
Graham Thomas P TP - - 2008
The purpose of this study was to assess the outcome of pulmonary valve replacement (PVR) in adults with moderate/severe pulmonary regurgitation after tetralogy repair, with particular emphasis on patient outcome, durability of valve repair, and improvement in symptomatology. The project committee of the International Society of Congenital Heart Disease undertook ...
Farè Silvia - - 2008
BACKGROUND AND AIM OF THE STUDY: Björk-Shiley Delrin (BSD) tilting-disc mechanical valve occluders have demonstrated good performance, with superior patient survival and low incidence of obstruction phenomena compared to caged-ball valves. Unfortunately, the use of Delrin as the occluder material was problematic, and in 1971 this led to its replacement ...
Migneco Francesco - - 2008
In this article, we will review the current state of the art in heart valve tissue engineering. We provide an overview of mechanical and biological replacement options, outlining advantages and limitations of each option. Tissue engineering, as a field, is introduced, and specific aspects of valve tissue engineering are discussed ...
Ryan Ronan - - 2008
Recent studies have established that cardiac MDCT generates high-quality images of the cardiac valves. Images are acquired during a single breath-hold (inspiration) after the injection of iodinated contrast material (5 mL/s) followed by a saline bolus chaser. Incremental data sets are then reconstructed throughout the R-R interval, and after transfer ...
Rallidis Loukianos S - - 2008
We present a patient with a history of a Sorin tilting disc prosthetic mitral valve implanted 20 years ago who developed acute dyspnoea. Echocardiogram revealed a unique pattern of 'obstruction alternans' of mitral valve prosthesis due to pannus formation. We emphasize the need for urgent surgical treatment of this potentially ...
Stephens Elizabeth H - - 2008
This study characterized valve proteoglycan and glycosaminoglycan composition during development and aging. This knowledge is important for the development of age-specific tissue-engineered heart valves as well as treatments for age-specific valvulopathies. Aortic valves and mitral valves from first-third trimester, 6-week, 6-month and 6-year-old pigs were examined using immunohistochemistry for versican, ...
Tanaka Keizo - - 2008
Open heart surgery in patients with myelodysplastic syndrome (MDS) increases the risk of bleeding and infection. We document a 78-year-old female with severe aortic valve stenosis and MDS who underwent aortic valve replacement with stentless porcine prosthesis. Perioperatively, a transfusion of red blood cells (RBCs) and an infusion of granulocyte ...
Nozohoor Shahab - - 2008
BACKGROUND: Bioprostheses for supraannular placement have been developed to optimize the hemodynamic performance after aortic valve replacement. To evaluate the potential benefit of this design, we analyzed the influence of prosthesis-patient mismatch on diastolic function and left ventricular mass regression and evaluated the clinical performance of the Sorin Soprano and ...
Yuan Shi-Min - - 2008
BACKGROUND: The valved conduit of choice in right ventricular outflow tract (RVOT) reconstruction provides a challenge for cardiac surgeons. The present study collected data regarding the clinical outcome of valved conduits for RVOT reconstruction, so as to explore various options of ideal conduits in clinical practice. METHODS: English language articles ...
Yoshikawa Kazuhiro - - 2008
BACKGROUND: The use of small aortic valve prostheses is still controversial because of negative effects caused by residual obstruction of the left ventricular outflow tract. This study evaluated the long-term results after aortic valve replacement with a small valve from St. Jude Medical (St. Paul, MN). METHODS: Between 1980 and ...
van Gameren Menno - - 2008
BACKGROUND: The EuroSCORE (European System for Cardiac Operative Risk Evaluation) is often used to benchmark and predict hospital mortality after cardiac surgery. Based mainly upon coronary surgery patients, EuroSCORE may not be optimal for valve surgery patients. We evaluated the New York (NY) State dedicated valve surgery models and compared ...
Aggarwal Neera - - 2008
The case is presented of a native valve endocarditis caused by Candida sake in a 34-year-old farmer with no history of intravenous drug abuse or pre-existing valvular abnormality. The patient presented with septicemia and multiorgan dysfunction syndrome (MODS). Clinical and diagnostic work-up revealed findings of severe aortic regurgitation and large ...
Krol Vitaliy - - 2008
Q fever is a zoonotic infection caused by Coxiella burnetii. The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, ...
Reamon-Buettner Stella Marie - - 2008
Hypoplasia of the human heart is the most severe form of congenital heart disease (CHD) and usually lethal during early infancy. It is a leading cause of neonatal loss, especially in infants diagnosed with hypoplastic left heart syndrome (HLHS), a condition where the left side of the heart including the ...
Scherz Paul J - - 2008
Knowing how mutations disrupt the interplay between atrioventricular valve (AVV) morphogenesis and function is crucial for understanding how congenital valve defects arise. Here, we use high-speed fluorescence microscopy to investigate AVV morphogenesis in zebrafish at cellular resolution. We find that valve leaflets form directly through a process of invagination, rather ...
Namboodiri Narayanan - - 2008
AIMS: TTK Chitra heart valve prosthesis (CHVP), a tilting disc mechanical heart valve of low cost and proven efficacy, has been in use for the last 15 years. Although various studies substantiating its long-term safety and efficacy are available, no study had assessed its echocardiographic characteristics. The purpose of this ...
Lehmann Sven - - 2008
OBJECTIVE: The aim of this prospectively randomized study was to evaluate the hemodynamic and functional outcomes after aortic valve replacement with three different bileaflet mechanical valves. METHODS: From March 1996 to August 1998, 300 consecutive patients were randomly assigned to receive ATS (n = 100), Carbomedics (n = 100), or ...
Pavcnik Dusan - - 2008
Lower extremity chronic deep venous insufficiency (CDVI) is common and remains a major health problem worldwide. Selected patients benefited from direct deep vein valve surgical repair or valve transplantation. A major limitation of this approach is that most of the patients are not candidates for these procedures due to obstructions ...
Mellwig Klaus Peter - - 2008
Physical check-ups among athletes with valvular heart disease are of significant relevance. In athletes with mitral valve stenosis the extent of allowed physical activity is dependant on the size of the left atrium and the severity of the valve defect. Patients with mild-to-moderate mitral valve regurgitation can participate in all ...
Donnelly Kevin B - - 2008
Recent voluntary withdrawal of the ergoline-derivative Alzheimers' drug Pergolide (Permax) resulting from demonstrated risk of cardiac valve injury illustrates the increased importance of valve injury in pharmaceutical toxicology. Following the 2001 landmark discovery of cardiac valve injury associated with the widely prescribed anti-obesity drug combination fenfluramine-phentermine, and subsequent withdrawal, the ...
Sydow K - - 2008
Cardiac papillary fibroelastomas (CPFs), the second most common primary cardiac tumor, are benign endocardial papillomas predominantly affecting the cardiac valves. Although CPFs are rare and benign tumors, they may result in life-threatening complications. Early diagnosis of this condition is important, since it represents a surgically correctable cause of systemic embolism, ...
Hoffmann Grischa - - 2008
The choice of type of heart valve prosthesis is determined by the patient's age since bioprostheses have a limited lifespan. This article reviews current recommendations and the literature on cardiac valve replacement. Selective literature search in Medline/PubMed back to 1996 and review of current national and international recommendations from specialist ...
Jones Charles Bradley - - 2008
Thrombosis of prosthetic heart valves is well known; however it rarely occurs on native heart valves. To our knowledge there are no reports of native aortic valve thrombus in the absence of blood dyscrasia or prior valve pathology. We describe a patient who presented with a non-ST segment elevation myocardial ...
Morsi, Yos S.
The concept of tissue-engineered heart valves offers an alternative to current heart valve replacements that is capable of addressing shortcomings such as life-long administration of anticoagulants, inadequate durability, and inability to grow. Since tissue engineering is a multifaceted area, studies conducted have focused on different aspects such as hemodynamics, cellular ...
Tokunaga Shigehiko - - 2008
The American College of Cardiology/American Heart Association guidelines for the management of patients with valvular heart disease were revised in 2006. These guidelines are introduced in this review, and the current status of the mechanical valve, bioprosthesis, and treatment of valvular heart disease are described based on the new guidelines ...
Laco Jan - - 2008
Nonbacterial thrombotic endocarditis (NBTE) is a well-known complication of hypercoagulable states, particularly in patients with malignancies. Its complications comprise thrombembolism rather than valvular dysfunction. We present a case of a 71-year-old man treated for colonic carcinoma, who died 1 month after tumor resection with clinical signs of respiratory failure. Ante ...
Krasopoulos George - - 2008
OBJECTIVES: Commercially available conduits containing a valve are not always suitable for simultaneous reconstruction of the left ventricular outflow tract and replacement of the aortic root. We describe our experience with custom-made conduits for patients with complex disease of the aortoventricular junction. METHODS: Twenty-seven patients with a destroyed aortoventricular junction ...
Tokunaga Shigehiko - - 2008
The long-term outcome of isolated tricuspid valve replacement is unclear because this procedure is rare and usually performed in combination with replacement of other valves. The results of all 31 isolated tricuspid valve replacements carried out in 23 patients in Kyushu University Hospital between 1975 and 2004 were retrospectively reviewed. ...
Umesh Goneppanavar - - 2008
Patients with prosthetic heart valves are a challenge to any anesthesiologist due to the risk of infective endocarditis, bleeding and thrombosis. We present anesthetic management of a 58-year-old Indian lady with a prosthetic (mechanical) heart valve who underwent hemireplacement arthroplasty. Patients with prosthetic heart valves, especially those with the mechanical ...
Westling Katarina - - 2008
We report a case of infective endocarditis caused by Actinobacillus actinomycetemcomitans (Aggregatibacter actinomycetemcomitans) from the HACEK group diagnosed by PCR/16S from the heart valve. Multiple blood cultures and cultures from heart valve were negative and cardiac surgery was performed due to therapeutic and cardiac failures. Molecular biological methods are useful ...
Habib Gilbert - - 2008
Despite improvements in medical and surgical therapy, prosthetic valve endocarditis is still associated with a severe prognosis, and remains a diagnostic and therapeutic challenge. Diagnosis of prosthetic valve endocarditis is more difficult than that of the native valve endocarditis and the application of Duke criteria is less useful in this ...
Iqbal Javaid - - 2008
Myocardial abscess is a rare and potentially fatal condition. Metastatic myocardial abscess in the setting of infective endocarditis has been infrequently reported in the medical literature. To the best of the authors' knowledge no case of myocardial abscess affecting the free wall of the left ventricle secondary to infective endocarditis ...
Hall M B - - 2008
Selected vessel types and conditions used for in vitro fermentation were compared to evaluate their effects on determinations of neutral detergent fiber (NDF) digestibility (NDFD) in 2 replicate 48-h fermentations. Treatments included 50-mL polyethylene centrifuge tubes with gas-release valves (treatment 1); 50-mL polyethylene centrifuge tubes with continuous gassing with CO2 ...
Mol Anita - - 2008
Cardiovascular diseases, such as heart valve dysfunction and coronary artery stenosis, are next to cancer the leading cause of death in the US. Treatments involve replacement of the heart valve or bypassing the obstructed coronary artery with a small-diameter vascular graft. The major limitation of currently used replacements is their ...
Del Gaudio C - - 2008
Currently marketed mechanical or biological prosthetic heart valves are regarded as valid substitutes for native heart valves suffering from degenerative pathologies. These devices require strict follow-up due to dysfunctions or post-surgical complications. Potential drawbacks of these medical devices are calcification, tearing of the cusps, thromboembolism and hemolysis. In this context, ...
Iakobishvili Zaza - - 2008
BACKGROUND: There are few reports regarding acute coronary syndromes (ACS) in patients with prosthetic heart valves (PHV), mostly attributing the ACS to a PHV-derived coronary embolus. OBJECTIVE: To characterize a case-series of ACS patients with PHV. METHODS: All patients in our institution with previous PHV surgery and ACS during 1996-2005 ...
Knight R L RL Institute of Medical & Biological Engineering, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK. - - 2008
Tissue-engineering approaches to cardiac valve replacement have made considerable advances over recent years and it is likely that this application will realize clinical success in the near future. Research in this area has been driven by the inadequacy of the currently available cardiac valve prostheses for younger patients who require ...
Schelbert E B - - 2008
OBJECTIVE: To compare outcomes after aortic valve replacement (AVR) according to valve type specifically in older patients since valve-related risks are age-dependent; two randomised trials comparing mechanical and bioprosthetic valves found better outcomes with mechanical valves, but the samples were small and the patients were considerably younger than most who ...
Emery Robert W - - 2008
Anticoagulation management issues following mechanical cardiac valve replacement revolve around target levels for chronic oral anticoagulation. While these levels are important, they are only one aspect of a follow-up process that should be individualized to each patient with a mechanical cardiac valve and coupled with patient education, risk factor modification, ...
Loukas Marios - - 2007
Raymond de Vieussens provided significant insight into more than one area of medicine and opened up the field of research for decades to come. Raymond de Vieussens was born in France and graduated with his medical doctorate in 1670 from the University of Montpellier. After graduation Vieussens was appointed as ...
Ulus A Tulga - - 2007
OBJECTIVE: The aim of this study was to investigate the response of heart to stress according to the size of the prosthetic valve in patients who had undergone mitral valve replacement by using dobutamine stress echocardiography (DSE) and to evaluate the relationship between the size of the prosthetic valve and ...
Marques Carvalho Sandra Regina - - 2008
OBJECTIVE: The aims of this study were to assess the feasibility of performing a complete fetal echocardiographic study during the first trimester of pregnancy, to establish the best week to accomplish a complete evaluation, and to find a relationship between the diameters of the cardiac valves and gestational age. METHODS: ...
Grammer Joachim B - - 2007
BACKGROUND AND AIM OF THE STUDY: Tissue neovascularization is a major event in the development and dissemination of inflammatory diseases, such as infective endocarditis (IE). Although the molecular triggers which allow vascular ingrowth in the aforementioned avascular regions are not well understood, they may represent potential prophylactic or therapeutic targets. ...
Brody Sarah - - 2007
Heart valve disease is a significant cause of mortality worldwide. However, to date, a nonthrombogenic, noncalcific prosthetic, which maintains normal valve mechanical properties and hemodynamic flow, and exhibits sufficient fatigue properties has not been designed. Current prosthetic designs have not been optimized and are unsuitable treatment for congenital heart defects. ...
Sezai Akira - - 2007
PURPOSE: The Starr-Edwards ball valve was first applied clinically in 1960. In our hospital, this valve has been used since 1963, and some patients have been followed up for 30 years or more. Based on our experience, therapeutic strategies included revalve replacement as a preventive procedure in the absence of ...
Chopra P - - 2007
Cardiovascular disease is on the rise. In India and other developing countries, rheumatic heart disease (RHD) continues to be a major public health problem and contributes to significant cardiac morbidity and mortality. RHD in the juvenile age group namely juvenile mitral stenosis is a variant which is unique to the ...
Koertke Heinrich - - 2007
AIMS: In mechanical heart valve recipients, low-dose international normalized ratio (INR) self-management of oral anticoagulants can reduce the risk of developing thrombo-embolic events and improve long-term survival compared with INR control by a general practitioner. Here, we present data on the safety of low-dose INR self-management. METHODS AND RESULTS: In ...
Eichinger Walter - - 2007
OBJECTIVE: The approval of a heart valve for the European market takes place in accordance with European and international standards. A new version of the EN Standards was published in June 2006, which responded to different technical innovations in the area of heart valve technology. This work outlines the differences ...
Kalkat Maninder S - - 2007
BACKGROUND: Composite aortic valve and root replacement (CVG) is a complex surgical procedure, but excellent center-specific outcomes are reported. We sought to report outcomes in a national cohort. METHODS AND RESULTS: The United Kingdom Heart Valve Registry was interrogated for 1962 first-time CVG (and 37,102 aortic valve replacements [AVR] as ...
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