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Schenke-Layland Katja - - 2009
To increase the supply, many countries harvest allograft valves from explanted hearts of transplant recipients with ischaemic (ICM) or dilated cardiomyopathy (DCM). This study determines the structural integrity of valves from cardiomyopathic hearts. Extracellular matrix (ECM) was examined in human valves obtained from normal, ICM, and DCM hearts. To confirm ...
Sacks Michael S MS Department of Bioengineering, Engineered Tissue Mechanics and Mechanobiology Laboratory, The McGowan Institute, University of Pittsburgh, Pittsburgh, PA, United States. - - 2009
Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood flow during the cardiac cycle. However, this description does not adequately describe the biomechanical ramifications of their function in that their mechanics are multi-modal. Moreover, they must replicate their cyclic function over an entire lifetime, with ...
Sial Jawaid Akbar - - 2009
A 24-year-old male patient with anterior myocardial infarction, caused by embolization from mitral valve prosthesis due to inadequate anticoagulation is presented. The patient underwent cardiac catheterization within 90 minutes of arrival. Angiography showed total occlusion of the left anterior descending coronary artery (LAD) after the second diagonal branch. Thrombus was ...
Villalba R - - 2009
Several reports have shown liquid nitrogen containers as not being sterile. Microorganism transmission has been observed in different cells and tissues stored under this condition, but there is no data on contamination of stored human valves. We performed a survey on heart valve banking in Spain. Regarding the questionnaire, we ...
Barron David J - - 2010
Heart valve allografts (usually referred to as 'homografts') have been used in cardiac surgery for over 45 years when they were amongst the first valves ever used. Today they remain an important part of valve replacement and reconstructive surgery, particularly in the field of congenital heart disease. There are currently ...
Mol Anita - - 2009
It is estimated that the number of patients requiring heart valve replacement will triple over the next five decades. None of the current replacement valves can fully restore native valve function because they lack growth and remodeling capabilities. Heart valve tissue engineering is a promising technology to overcome these limitations. ...
Khan N A - - 2009
Prosthetic heart valve dysfunction due to thrombus or pannus formation can be a life-threatening complication. The present report describes a 47-year-old woman who developed valvular cardiomyopathy after chorda-sparing mitral valve replacement, and subsequently underwent heart transplantation for progressive heart failure. The explanted mitral valve prosthesis showed significant thrombus and pannus ...
Alsoufi Bahaaldin - - 2009
OBJECTIVE: We aimed to identify characteristics differentiating children undergoing aortic valve replacement by using mechanical prostheses versus the Ross procedure and to compare survival and the need for aortic valve reoperation after each procedure. METHODS: From 1983 to 2004, 346 children underwent aortic valve replacement (215 underwent the Ross procedure ...
Ricci Marco - - 2009
BACKGROUND: Multiple valve surgery was performed utilizing beating heart technique through simultaneous antegrade/retrograde perfusion with blood. We herein report our experience with this technique in patients with multiple valve disease processes. METHODS: Of 520 consecutive patients operated upon utilizing this method between 2000 and 2007, 59 patients underwent multiple valve ...
Paryani M R - - 2009
The Caspian miniature horse is one of the rare small breeds in the north of Iran. In the present study, the position of the heart and its valves were determined topographically in 4 miniature horses. We found that Caspian miniature horses have general similarities, with certain topographical variability, with other ...
Chiam Paul T L - - 2009
Aortic stenosis (AS) is currently the most common valvular abnormality in developed countries. The gold standard treatment of severe symptomatic AS is surgical aortic valve replacement. Mechanical valves were initially the prostheses of choice; with improvement of surgical technique and results, and increased durability of bioprosthetic valves, there has been ...
Böhm Jürgen O - - 2009
BACKGROUND: Although the Ross operation requires double-valve replacement for aortic valve pathology, it is the only autologous, aortic valve replacement available. We report a single-unit's 11-year experience. METHODS: Before August 2006, 467 patients (mean age, 41 +/- 15 years; 358 males) underwent a Ross operation. The right ventricular outflow tract ...
Thomas Timothy H - - 2009
OBJECTIVE: Optimal cannula position is essential during extracorporeal membrane oxygenation (ECMO). We hypothesize that echocardiography is superior to chest radiography in diagnosing abnormal cannula position during ECMO. DESIGN: Retrospective. SETTING: Pediatric hospital. PATIENTS: 100 pediatric patients requiring ECMO. MEASUREMENTS AND MAIN RESULTS: We reviewed the medical records of all ECMO ...
Bajraktari Gani - - 2009
Different techniques are used for the right ventricular outflow tract reconstruction, including homo- or porcine xenografts, which have several limitations. Contegra, a bovine jugular vein graft, is an interesting alternative to overcome these limitations. It consists of a bovine jugular vein with a naturally integrated valve in it. Isolated pulmonary ...
Hilberath Jan N - - 2009
BACKGROUND: Measuring the aortic valve area (AVA) remains an important component of a comprehensive intraoperative echocardiographic examination in patients undergoing aortic valve surgery. Epicardial echocardiography (EE) represents an accessible alternative to transesophageal echocardiography (TEE), however, its agreement and correlation with other imaging modalities for measuring AVA has not been systematically ...
Kidane Asmeret G - - 2009
Valve replacement is the most common surgical treatment in patients with advanced valvular heart disease. Mechanical and bio-prostheses have been the traditional heart valve replacements in these patients. However, currently the heart valves for replacement therapy are imperfect and subject patients to one or more ongoing risks, including thrombosis, limited ...
Cola Clarissa - - 2009
Left main stem coronary artery (LMSCA) stenosis after surgical aortic valve replacement (AVR) is a rare but potentially lethal complication. Among the different possible causes, antegrade cardioplegia for direct coronary perfusion seems to be the most significant and prevalent. Here we discuss two cases of late presentation of iatrogenic coronary ...
Scharfschwerdt Michael - - 2009
A major concern with mechanical heart valve prostheses is still the need for lifelong anticoagulation to prevent valve thrombosis and thrombembolism. Knowledge of the localization of initial thrombus formation on the prosthesis may help to improve valve design. Since observation of early clot deposition in vivo is difficult, the aim ...
El-Hamamsy Ismail - - 2009
Heart valves have long been considered exclusively passive structures that open and close in response to changes in transvalvular pressure during the cardiac cycle. Although this is partly true, recent evidence suggests that valves are far more sophisticated structures. Microscopic examination of heart valves reveals a complex network of endothelial ...
Sacks Michael S - - 2009
Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is now commonplace and enhances survival and quality of life for many patients. However, repairs of congenital deformities require very small valve sizes not commercially available. Further, a fundamental problem inherent to the use of existing mechanical and ...
Iaizzo Paul A PA Departments of Surgery and Integrative Biology and Physiology, the Carlson School of Management, and the Institute for Engineering in Medicine at the University of Minnesota, Minneapolis, MN 55455 USA. - - 2009
The reanimation of large mammalian hearts, including those of humans, using Visible Heart methodologies provides a unique perspective of functional cardiac anatomy. This knowledge is critical for design engineers and clinicians who seek less invasive cardiac repair approaches for patients with acquired or congenital structural heart defects.
Laske Tim T Medtronic, Inc., Moundsview, MN 55112, USA. - - 2009
Although the heart valve market is relatively mature, many patients currently indicated for valve repair or replacement are either undiagnosed, not referred for surgery, or are too sick/unwilling to undergo the required surgery (Table I). To address this unmet clinical need, the medical device industry has undertaken the development of ...
Colacioppo-Saavedra Ricardo - - 2008
BACKGROUND: Heart valve surgery is the second most common type of cardiac surgery. However, there is limited information about the outcomes associated to these types of surgeries. METHODS: A retrospective review was performed in 91 Puerto Rican patients who underwent elective heart valve replacement surgery at the Cardiovascular Center of ...
Ikee Ryota - - 2008
Heart valve calcification is an important predictor for all-cause and cardiovascular mortality in hemodialysis patients. Recently, serum beta(2)-microglobulin has been associated with cardiovascular disease in the non-hemodialysis population, but the relationship between serum beta(2)-microglobulin and valve calcification remains unknown. In this cross-sectional study, we recorded the patients' clinical parameters, including ...
Sharma Shikha - - 2009
Current guidelines necessitate varying degrees of long-term anticoagulation in patients with mechanical heart valve(s) to prevent thrombotic and embolic complications. We describe a patient with a functioning aortic mechanical valve without anticoagulation for 23 years. A 68-year-old man had an aortic valve (St Jude Medical) replacement in 1984. His native ...
Villemot Jean-Pierre - - 2008
BACKGROUND AND AIM OF THE STUDY: The study aim was to update the authors' experience with aortic valve replacement (AVR) using the ATS mechanical prosthesis in terms of early and long-term outcome in routine practice. METHODS: This retrospective analysis was extracted from clinical data available between April 1996 and February ...
Reinsch Nico - - 2008
Infective endocarditis (IE) due to Gram-negative bacteria is a rare occurrence, with a relative frequency of less than 10% compared to that caused by Gram-positive bacteria. Herein is presented the fatal case of a 66-year-old man who had undergone mechanical aortic valve replacement 10 years previously, and developed aortic valve ...
Ree Ronald M - - 2008
PURPOSE: To describe both the evolution and the main associated complications in the anesthetic management of the initial 40 patients at our centre who underwent percutaneous retrograde aortic valve replacement, a novel technique utilizing a catheter-guided femoral artery approach. CLINICAL FEATURES: With institutional Research Ethics Board approval, we retrospectively reviewed ...
Sakhaeimanesh A A - - 2008
The effect of oscillation on elevating turbulent shear stresses through the Jellyfish and St. Vincent valves has been investigated. Laser Doppler anemometry was employed to determine the velocity and shear stress distributions at various locations downstream of the valves. Comparison between two valves revealed that at 0.5D downstream of the ...
Laksman Zachary - - 2008
Bioprosthetic valves are generally considered to carry a low risk of valve thrombosis, obviating the need for long-term anticoagulation in most patients. Few reports exist of the diagnostic characteristics and management of bioprosthetic valve thrombosis. Herein is presented a case of critical bioprosthetic mitral valve thrombosis in which successful clinical ...
Yébenes J C - - 2008
Needleless valve connectors were introduced to avoid needlestick injuries in healthcare workers but some concerns exist about their microbiological safety. A randomised controlled trial was performed to assess hub colonisation affecting positive-pressure valve connectors (PPVCs) compared to conventional caps used for radial arterial catheters inserted into critically ill patients. Patients ...
Rodriguez Rosendo A RA Division of Cardiac Surgery, Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, - - 2009
The difficulty of distinguishing solid from air emboli using transcranial Doppler has limited its use in situations where both types of emboli can occur, such as in mechanical heart valve patients. To make transcranial Doppler clinically useful, a method must be found to distinguish benign air bubbles from the more ...
Krakow E F - - 2009
Cardiac surgery for coronary heart disease, and for calcific and degenerative valvular heart disease, will likely become more frequent with an ageing haemophilia population. Our report describes the successful management of an individual with mild haemophilia B undergoing elective aortic valve replacement using a continuous infusion of recombinant factor IX. ...
Herbertson Luke H - - 2008
The closing behavior of mechanical heart valves is dependent on the design of the valve and its housing, the valve composition, and the environment in which the valve is placed. One innovative approach for improving the closure dynamics of tilting disk valves is introduced here. We transformed a normal Delrin ...
Mertsching H - - 2008
Cardiovascular tissue engineering is a fast evolving field of biomedical science and technology to manufacture viable blood vessels, heart valves, myocardial substitutes and vascularised complex tissues. In consideration of the specific role of the haemodynamics of human circulation, bioreactors are a fundamental of this field. The development of perfusion bioreactor ...
Asopa Sanjay - - 2009
Heart lesions in patients with rheumatoid arthritis (RA) are well documented in literature; however, in the majority of cases these are incidental findings at postmortem. Most patients do not require cardiac surgical intervention unless they develop complications such as significant valvular regurgitation. Patients with RA often require orthopedic operations and ...
Katayama Susumu - - 2008
OBJECTIVE: Recently, various modifications have been made to aortic root replacement procedures to include the pseudosinus in the synthetic graft, but its effect on valve function still remains to be elucidated. The purpose of this study was to compare the flow dynamics and its influence on the stress/strain in the ...
He Guo-Wei - - 2008
OBJECTIVES: In older children (>four years) and adults the strategy of repair of tetralogy of Fallot (TOF) should have a low rate of transannular patch to avoid pulmonary insufficiency (PI), and in addition, we developed a new method of reconstruction of the right ventricular outflow tract (RVOT) to reduce PI. ...
Luciani Giovanni Battista - - 2008
To define risk and outcome of surgery in adults with congenital valve disease (CVD), experience between 2002 and 2005 with 371 CVD operations (288 males, aged 56 +/- 9 years) was compared with 2102 for acquired valve disease (AVD) (69 +/- 22 years, p = 0.02). Diagnosis included: bicuspid aortic ...
Nowicki Edward R - - 2008
BACKGROUND: Aortic valve allograft reoperation is a challenge for the surgeon and a risk to the patient. We examined our experience to identify these challenges and risks. METHODS: From April 1987 to January 2006, 130 patients underwent first-time allograft-related reoperations. Prior implant was subcoronary 32 (25%), inclusion-root 28 (22%), and ...
Yébenes Juan Carlos - - 2008
OBJECTIVE: Disinfectable needle-free closed connectors were designed to avoid needle-stick injuries and to be easily disinfected before handling. Workloads or lack of knowledge, however, could impede the correct handling of these devices, allowing endoluminal catheter colonization. The aim of our study was to assess the barrier effect of different disinfectable ...
Payne Darrin M - - 2008
BACKGROUND: Several trials have compared stentless with stented valves following aortic valve replacement (AVR). The goal of this review was to systematically locate, critically appraise, and quantitatively combine results to determine if stentless valves improve cardiac hemodynamics. METHODS: We performed an unrestricted search of Pubmed Medline, EMBASE, CINAHL, the Cochrane ...
Horiguchi Masahide - - 2008
A 63-year-old woman who had undergone aortic valve replacement (AVR) with a 22-mm Medtronic Hall valve in May 1994 was admitted to the authors' hospital in June 2006 with epigastric pain and nausea. She presented with sudden precipitous deterioration of hemodynamics under high-dose catecholamines, but this improved in ca. 10 ...
O'Rullian James J - - 2008
A 71-year-old high-risk fourth-time redo male patient was diagnosed with prosthetic valve endocarditis of both aortic and mitral valves, and subsequently required a re-operative aortic and mitral valve replacement. He was placed on cardiopulmonary bypass (CPB) and arrested with normothermic hyperkalemic all-blood cardioplegia (microplegia) containing adjunctive adenosine-lidocaine-magnesium (adenocaine); aerobic arrest ...
Minami Hiroya - - 2008
An 80-year-old woman had undergone initial mitral valve replacement using a Björk-Shiley mechanical valve owing to mitral stenosis 25 years earlier. Suddenly, she had anemia and an increased lactic dehydrogenase (LDH) level. Transesophageal echography (TEE) showed perivalvular leakage. In a redo operation, two side-by-side stitches of the valve on the ...
Scharfschwerdt Michael - - 2008
In this study, we report on our first experience with the construction of a valve using autologous vena cava tissue for right ventricular outflow tract reconstruction. Simulating the clinical situation valves were built from tubular pieces of porcine inferior vena cava placed in a PTFE tube and investigated in a ...
Khair Tarif - - 2010
Primary cardiac tumors are very rare. Cardiac Papillary Fibroelastoma (CPF) is the third most common primary tumor of the heart and most commonly affects cardiac valves. Those tumors appear like a "sea anemone" with multiple papillary fronds attached to the endocardium by a short stalk. It generally occurs as a ...
Bochenek-Klimczyk Krystyna - - 2008
Here we report the early clinical results of a new preassembled stentless valved-conduit incorporating artificial sinuses of Valsalva (BioValsalva). This new composite conduit incorporates a stentless porcine aortic valve (Elan, Vascutek Terumo, UK) suspended within a triple-layered vascular conduit (Triplex, Vascutek Terumo, UK) constructed with sinuses of Valsalva. Between December ...
Chambers John B - - 2008
OBJECTIVE: A stented bovine pericardial valve might be less obstructive than a stented porcine valve. This study compared early hemodynamic function in a prospective series of 99 patients randomized to receive either a Mosaic or Perimount replacement aortic valve. METHODS: Echocardiography was performed early after surgery and at 1 year ...
Anderson Sara E - - 2008
PURPOSE: The purpose of this study was to quantify and characterize venous valves within the major left ventricular (LV) veins of human hearts. METHODS: Fiberscope cameras were inserted into the coronary sinus and were manipulated to major LV coronary veins of perfusion fixed human hearts (n = 26). Observed venous ...
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