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Yang Lifang - - 2010
BACKGROUND: Cardiac ischemia-reperfusion injury after cardiopulmonary bypass contributes to postoperative morbidity and mortality in patients with open-heart surgery. This randomized controlled trial was designed to address the protective effects of electroacupuncture (EA) pretreatment on myocardial injury in patients undergoing heart valve replacement surgery. METHODS: Sixty patients with acquired heart valve ...
Peacock Jacqueline D - - 2010
Calcification of heart valve structures is the most common form of valvular disease and is characterized by the appearance of bone-like phenotypes within affected structures. Despite the clinical significance, the underlying etiology of disease onset and progression is largely unknown and valve replacement remains the most effective treatment. The SRY-related ...
Burriesci G - - 2010
Polymeric heart valves could offer an optimum alternative to current prostheses, by joining the advantages of mechanical and bioprosthetic valves. Though a number of materials suitable for this application have recently become available, significant improvements in the valve design are still needed. In this paper, a novel polymeric heart valve ...
Carabello Blase A - - 2010
Aortic valve disease imparts a pressure or volume overload on the left ventricle (LV). If this load is severe and prolonged, it eventually leads to LV damage, congestive heart failure (CHF), and death. These mechanical problems ultimately require mechanical correction in the form of valve replacement or repair, and the ...
Tsuji Atsutoshi - - 2010
This report describes the long-term (23 years) follow-up of a pediatric patient with acute lymphoblastic leukemia and eosinophilia who underwent multiple valve replacements. An 8-year-old boy with this complex disease was admitted in January 1984 and treated with 6-week course of vincristine, L-asparaginase, and prednisolone, which induced complete remission. He ...
Krishan Kewal - - 2010
In patients with left-sided mechanical aortic prostheses, it is recommended that the mechanical valve be replaced with a bioprosthesis, or excluded, at implantation of left ventricular assist device (LVAD). As changes in flow across the valve leads to potential thromboembolic complications, mechanical valves within the native heart are a relative ...
Camarata Troy - - 2010
Tbx5 is involved in congenital heart disease, however, the mechanisms leading to organ malformation are greatly unknown. We hypothesized a model by which the Tbx5 binding protein Pdlim7 controls nuclear/cytoplasmic shuttling and function of the transcription factor. Using the zebrafish, we present in vivo significance for an essential role of ...
Hjortnaes Jesper - - 2009
Tissue engineering is currently being actively investigated to ascertain if it can offer an alternative to prosthetic aortic heart valves that may overcome the current limitations of prosthetic aortic heart valves while at the same time conferring the advantages of a living autologous structure, such as biocompatibility, the capacity to ...
Abe Hidetoshi - - 2009
BACKGROUND: Recent studies suggest that treatment of heart failure (HF) could improve cardiac function and sleep apnea syndrome (SAS), but it is unknown how cardiac surgery may affect SAS in HF patients. Relationships between HF with valvular heart diseases and 2 types of SAS (obstructive sleep apnea (OSA) and central ...
Khandoker Ahsan H - - 2009
In this study, we propose a non-invasive algorithm to recognize the timings of fetal cardiac events on the basis of analysis of fetal ECG (FECG) and Doppler ultrasound signals. Multiresolution wavelet analysis enabled the frequency contents of the Doppler signals to be linked to the opening (o) and closing (c) ...
Sun Jack C J - - 2009
Over 4 million people worldwide have received a prosthetic heart valve, and an estimated 300,000 valves are being implanted every year. Prosthetic heart valves improve quality of life and survival of patients with severe valvular heart disease, but the need for antithrombotic therapy to prevent thrombotic complications in valve recipients ...
Zhai Wanyin - - 2009
Calcification is one of the key factors for short durability of glutaraldehyde-crosslinked bioprosthetic heart valves. We have shown previously that procyanidins (PC)-crosslinked heart valve matrix has low cytotoxicity, perfect mechanical properties, and ideal stability. The aim of this study is to investigate the anticalcification effect of procyanidins and its crosslinked ...
Siddiqui Raheela Fareed - - 2009
Valve replacement started in 1960, with the surgeon now having a significant variety of prosthetic heart valves from which to choose. These valves are broadly divided into mechanical heart valves (MHV) and bioprosthetic heart valves (BHV). Improvements in the performance and ease of usage of BHV without the need for ...
Mak Gary S - - 2009
AIMS: The coronary sinus (CS) is a commonly cannulated structure in patients undergoing electrophysiology studies, catheter ablation of arrhythmias, implantation of resynchronization therapy devices and, more recently, percutaneous mitral valve repair. The advent of these procedures has led to a renewed interest in the anatomy of the coronary venous system ...
Stewart Ralph A H - - 2009
PURPOSE OF REVIEW: To summarize evidence from clinical trials of heart valve disease and identify areas where further trials are needed. RECENT FINDINGS: Recent randomized studies suggest that statins do not influence progression of aortic stenosis. Other medical therapies with the potential to reduce progression of valve disease or decrease ...
Seeburger Joerg - - 2009
A 66-year-old patient with previous mitral valve replacement underwent redo surgery for severe secondary tricuspid valve regurgitation. The patient presented with right heart failure and was pacemaker-dependent prior to surgery. Tricuspid valve replacement and implantation of a cardiac pacemaker lead through the coronary sinus were performed. The operative procedure and ...
Schenke-Layland Katja - - 2009
To increase the supply, many countries harvest allograft valves from explanted hearts of transplant recipients with ischaemic (ICM) or dilated cardiomyopathy (DCM). This study determines the structural integrity of valves from cardiomyopathic hearts. Extracellular matrix (ECM) was examined in human valves obtained from normal, ICM, and DCM hearts. To confirm ...
Sacks Michael S - - 2009
Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood flow during the cardiac cycle. However, this description does not adequately describe the biomechanical ramifications of their function in that their mechanics are multi-modal. Moreover, they must replicate their cyclic function over an entire lifetime, with ...
Sial Jawaid Akbar - - 2009
A 24-year-old male patient with anterior myocardial infarction, caused by embolization from mitral valve prosthesis due to inadequate anticoagulation is presented. The patient underwent cardiac catheterization within 90 minutes of arrival. Angiography showed total occlusion of the left anterior descending coronary artery (LAD) after the second diagonal branch. Thrombus was ...
Villalba R - - 2009
Several reports have shown liquid nitrogen containers as not being sterile. Microorganism transmission has been observed in different cells and tissues stored under this condition, but there is no data on contamination of stored human valves. We performed a survey on heart valve banking in Spain. Regarding the questionnaire, we ...
Barron David J - - 2010
Heart valve allografts (usually referred to as 'homografts') have been used in cardiac surgery for over 45 years when they were amongst the first valves ever used. Today they remain an important part of valve replacement and reconstructive surgery, particularly in the field of congenital heart disease. There are currently ...
Mol Anita - - 2009
It is estimated that the number of patients requiring heart valve replacement will triple over the next five decades. None of the current replacement valves can fully restore native valve function because they lack growth and remodeling capabilities. Heart valve tissue engineering is a promising technology to overcome these limitations. ...
Khan N A - - 2009
Prosthetic heart valve dysfunction due to thrombus or pannus formation can be a life-threatening complication. The present report describes a 47-year-old woman who developed valvular cardiomyopathy after chorda-sparing mitral valve replacement, and subsequently underwent heart transplantation for progressive heart failure. The explanted mitral valve prosthesis showed significant thrombus and pannus ...
Alsoufi Bahaaldin - - 2009
OBJECTIVE: We aimed to identify characteristics differentiating children undergoing aortic valve replacement by using mechanical prostheses versus the Ross procedure and to compare survival and the need for aortic valve reoperation after each procedure. METHODS: From 1983 to 2004, 346 children underwent aortic valve replacement (215 underwent the Ross procedure ...
Ricci Marco - - 2009
BACKGROUND: Multiple valve surgery was performed utilizing beating heart technique through simultaneous antegrade/retrograde perfusion with blood. We herein report our experience with this technique in patients with multiple valve disease processes. METHODS: Of 520 consecutive patients operated upon utilizing this method between 2000 and 2007, 59 patients underwent multiple valve ...
Paryani M R - - 2009
The Caspian miniature horse is one of the rare small breeds in the north of Iran. In the present study, the position of the heart and its valves were determined topographically in 4 miniature horses. We found that Caspian miniature horses have general similarities, with certain topographical variability, with other ...
Chiam Paul T L - - 2009
Aortic stenosis (AS) is currently the most common valvular abnormality in developed countries. The gold standard treatment of severe symptomatic AS is surgical aortic valve replacement. Mechanical valves were initially the prostheses of choice; with improvement of surgical technique and results, and increased durability of bioprosthetic valves, there has been ...
Böhm Jürgen O - - 2009
BACKGROUND: Although the Ross operation requires double-valve replacement for aortic valve pathology, it is the only autologous, aortic valve replacement available. We report a single-unit's 11-year experience. METHODS: Before August 2006, 467 patients (mean age, 41 +/- 15 years; 358 males) underwent a Ross operation. The right ventricular outflow tract ...
Thomas Timothy H - - 2009
OBJECTIVE: Optimal cannula position is essential during extracorporeal membrane oxygenation (ECMO). We hypothesize that echocardiography is superior to chest radiography in diagnosing abnormal cannula position during ECMO. DESIGN: Retrospective. SETTING: Pediatric hospital. PATIENTS: 100 pediatric patients requiring ECMO. MEASUREMENTS AND MAIN RESULTS: We reviewed the medical records of all ECMO ...
Bajraktari Gani - - 2009
Different techniques are used for the right ventricular outflow tract reconstruction, including homo- or porcine xenografts, which have several limitations. Contegra, a bovine jugular vein graft, is an interesting alternative to overcome these limitations. It consists of a bovine jugular vein with a naturally integrated valve in it. Isolated pulmonary ...
Hilberath Jan N - - 2009
BACKGROUND: Measuring the aortic valve area (AVA) remains an important component of a comprehensive intraoperative echocardiographic examination in patients undergoing aortic valve surgery. Epicardial echocardiography (EE) represents an accessible alternative to transesophageal echocardiography (TEE), however, its agreement and correlation with other imaging modalities for measuring AVA has not been systematically ...
Kidane Asmeret G - - 2009
Valve replacement is the most common surgical treatment in patients with advanced valvular heart disease. Mechanical and bio-prostheses have been the traditional heart valve replacements in these patients. However, currently the heart valves for replacement therapy are imperfect and subject patients to one or more ongoing risks, including thrombosis, limited ...
Cola Clarissa - - 2009
Left main stem coronary artery (LMSCA) stenosis after surgical aortic valve replacement (AVR) is a rare but potentially lethal complication. Among the different possible causes, antegrade cardioplegia for direct coronary perfusion seems to be the most significant and prevalent. Here we discuss two cases of late presentation of iatrogenic coronary ...
Laske Tim - - 2009
Although the heart valve market is relatively mature, many patients currently indicated for valve repair or replacement are either undiagnosed, not referred for surgery, or are too sick/unwilling to undergo the required surgery (Table I). To address this unmet clinical need, the medical device industry has undertaken the development of ...
Scharfschwerdt Michael - - 2009
A major concern with mechanical heart valve prostheses is still the need for lifelong anticoagulation to prevent valve thrombosis and thrombembolism. Knowledge of the localization of initial thrombus formation on the prosthesis may help to improve valve design. Since observation of early clot deposition in vivo is difficult, the aim ...
Iaizzo Paul A - - 2009
The reanimation of large mammalian hearts, including those of humans, using Visible Heart((R)) methodologies provides a unique perspective of functional cardiac anatomy. This knowledge is critical for design engineers and clinicians who seek less invasive cardiac repair approaches for patients with acquired or congenital structural heart defects.
El-Hamamsy Ismail - - 2009
Heart valves have long been considered exclusively passive structures that open and close in response to changes in transvalvular pressure during the cardiac cycle. Although this is partly true, recent evidence suggests that valves are far more sophisticated structures. Microscopic examination of heart valves reveals a complex network of endothelial ...
Sacks Michael S - - 2009
Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is now commonplace and enhances survival and quality of life for many patients. However, repairs of congenital deformities require very small valve sizes not commercially available. Further, a fundamental problem inherent to the use of existing mechanical and ...
Colacioppo-Saavedra Ricardo - - 2008
BACKGROUND: Heart valve surgery is the second most common type of cardiac surgery. However, there is limited information about the outcomes associated to these types of surgeries. METHODS: A retrospective review was performed in 91 Puerto Rican patients who underwent elective heart valve replacement surgery at the Cardiovascular Center of ...
Ikee Ryota - - 2008
Heart valve calcification is an important predictor for all-cause and cardiovascular mortality in hemodialysis patients. Recently, serum beta(2)-microglobulin has been associated with cardiovascular disease in the non-hemodialysis population, but the relationship between serum beta(2)-microglobulin and valve calcification remains unknown. In this cross-sectional study, we recorded the patients' clinical parameters, including ...
Sharma Shikha - - 2009
Current guidelines necessitate varying degrees of long-term anticoagulation in patients with mechanical heart valve(s) to prevent thrombotic and embolic complications. We describe a patient with a functioning aortic mechanical valve without anticoagulation for 23 years. A 68-year-old man had an aortic valve (St Jude Medical) replacement in 1984. His native ...
Villemot Jean-Pierre - - 2008
BACKGROUND AND AIM OF THE STUDY: The study aim was to update the authors' experience with aortic valve replacement (AVR) using the ATS mechanical prosthesis in terms of early and long-term outcome in routine practice. METHODS: This retrospective analysis was extracted from clinical data available between April 1996 and February ...
Reinsch Nico - - 2008
Infective endocarditis (IE) due to Gram-negative bacteria is a rare occurrence, with a relative frequency of less than 10% compared to that caused by Gram-positive bacteria. Herein is presented the fatal case of a 66-year-old man who had undergone mechanical aortic valve replacement 10 years previously, and developed aortic valve ...
Ree Ronald M - - 2008
PURPOSE: To describe both the evolution and the main associated complications in the anesthetic management of the initial 40 patients at our centre who underwent percutaneous retrograde aortic valve replacement, a novel technique utilizing a catheter-guided femoral artery approach. CLINICAL FEATURES: With institutional Research Ethics Board approval, we retrospectively reviewed ...
Sakhaeimanesh A A - - 2008
The effect of oscillation on elevating turbulent shear stresses through the Jellyfish and St. Vincent valves has been investigated. Laser Doppler anemometry was employed to determine the velocity and shear stress distributions at various locations downstream of the valves. Comparison between two valves revealed that at 0.5D downstream of the ...
Laksman Zachary - - 2008
Bioprosthetic valves are generally considered to carry a low risk of valve thrombosis, obviating the need for long-term anticoagulation in most patients. Few reports exist of the diagnostic characteristics and management of bioprosthetic valve thrombosis. Herein is presented a case of critical bioprosthetic mitral valve thrombosis in which successful clinical ...
Yébenes J C - - 2008
Needleless valve connectors were introduced to avoid needlestick injuries in healthcare workers but some concerns exist about their microbiological safety. A randomised controlled trial was performed to assess hub colonisation affecting positive-pressure valve connectors (PPVCs) compared to conventional caps used for radial arterial catheters inserted into critically ill patients. Patients ...
Rodriguez Rosendo A - - 2009
BACKGROUND: The difficulty of distinguishing solid from air emboli using transcranial Doppler has limited its use in situations where both types of emboli can occur, such as in mechanical heart valve patients. To make transcranial Doppler clinically useful, a method must be found to distinguish benign air bubbles from the ...
Krakow E F - - 2009
Cardiac surgery for coronary heart disease, and for calcific and degenerative valvular heart disease, will likely become more frequent with an ageing haemophilia population. Our report describes the successful management of an individual with mild haemophilia B undergoing elective aortic valve replacement using a continuous infusion of recombinant factor IX. ...
Herbertson Luke H - - 2008
The closing behavior of mechanical heart valves is dependent on the design of the valve and its housing, the valve composition, and the environment in which the valve is placed. One innovative approach for improving the closure dynamics of tilting disk valves is introduced here. We transformed a normal Delrin ...
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