Search Results
Results 51 - 100 of 1697
1 2 3 4 5 6 7 8 9 10 >
Zhang Hualei - - 2011
Firefly luciferase (Fluc) reporter gene is an authentic marker for surviving stem cells. However, it is unable to visualize the intramyocardial delivery of stem cells or their impact on cardiac function. The investigators demonstrate that bioluminescence imaging (BLI) combined with magnetic resonance imaging (MRI) allows better assessment of cell delivery ...
Machida Taiichi - - 2010
BACKGROUND: -The acetylcholine-activated K(+) current (I(K,ACh)) is a novel candidate for atrial-specific antiarrhythmic therapy. This study investigates the involvement of I(K,ACh) in atrial fibrillation (AF) using NTC-801, a novel potent and selective I(K,ACh) blocker. METHODS AND RESULTS: -The effects of NTC-801, substituted 4-(aralkylamino)-2,2-dimethyl-3,4-dihydro-2H-benzopyran-3-ol, on I(K,ACh) and other cardiac ionic currents ...
Wolfram Oliver - - 2010
Atrial fibrillation (AF) is the most common clinically relevant cardiac arrhythmia. Prevalence and incidence rates are rising with the advancing population age. A severe complication of untreated AF is thrombus formation in the left atrial appendage with consecutive peripheral thromboembolism. Thus, AF is a major contributor to thromboembolic events, especially ...
Porterfield John E - - 2011
There are two implanted heart failure warning systems incorporated into biventricular pacemakers/automatic implantable cardiac defibrillators and tested in clinical trials: right heart pressures, and lung conductance measurements. However, both warning systems postdate measures of the earliest indicator of impending heart failure: left ventricular (LV) volume. There are currently no proposed ...
Benyounes Nadia N Department of Internal Medicine, Fondation Ophtalmologique Adolphe de Rothschild, 25-29, rue Manin, 75940 Paris Cedex 19, France. - - 2011
Transient left ventricular apical ballooning also called Takotsubo cardiomyopathy is a recently described cardiac syndrome. It often affects postmenopausal women having an acute physical or emotional stress, but it have also been described after convulsive status epilepticus. Although this association is rare and left ventricular function often recovers, it would ...
Zlochiver Sharon - - 2010
Current density threshold and liminal area are subthreshold parameters of the cardiac tissue that indicate its susceptibility to external and internal stimulations. Extensive experimental and theoretical research has been conducted to quantify these two parameters in normal conditions for both animal and human models. Here we employed a 2D numerical ...
Patel Chetan B - - 2010
Both acute and chronic systolic heart failure can progress to an advanced phase, resulting in stage D heart failure and even cardiogenic shock. Despite significant progress in the treatment of systolic heart failure using medical and device therapies, this terminal phase continues to be prevalent and associated with unacceptably high ...
van den Hondel Karen Eline - - 2010
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of heart failure. NSAIDs inhibit the synthesis of renal prostaglandin, which results in a higher total blood volume, cardiac output and preload. The association between recent start of NSAIDs in elderly people and echocardiographic parameters was investigated. Methods In ...
Ciaccio Edward J - - 2011
Differences in dominant frequency (DF), a measure of electrical activation rate, were used to characterize and classify ventricular tachyarrhythmias (VTA) at onset. In canine 3- to 5-day-old infarct border zone, monomorphic re-entrant ventricular tachycardia (MVT) was repeatedly induced by programmed electrical stimulation (14 experiments, total of 23 instances used for ...
Weiss Robert M - - 2011
The aim of this study was to determine the impact of prolonged left ventricular assist device (VAD) support on cardiac ventricular geometry and VAD flow kinetics. Nineteen patients with end-stage heart failure underwent the implantation of HeartMate II rotary flow VADs. Left and right ventricular geometry and VAD flow kinetics ...
Agusala Kartik - - 2010
Adults with congenital heart defects and congestive heart failure are a challenging population because of their complex anatomy, prior surgical palliation, and hemodynamic status. We report one of the first cases of a ventricular assist device placement in a patient with decompensated heart failure and a history of D-transposition of ...
Jennings Douglas L - - 2010
The extended use of an Impella LP 2.5 percutaneous left-ventricular assist device (pVAD) without a heparin-based purge solution in a patient who developed cardiogenic shock after acute myocardial infarction (AMI) is described. A 58-year-old Asian man with no history of cardiac disease, hypertension, or diabetes mellitus had an AMI and ...
Stepanenko Alexander - - 2010
We report a case of accidental intraperitoneal tunneling of the driveline of a left ventricular assist device, which was detected at time of pump exchange. The driveline was completely wrapped with the greater omentum. This technical mistake made during the original left ventricular assist device implantation enabled the patient to ...
Gariboldi Vlad - - 2010
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is an effective technique to provide emergency mechanical circulatory or respiratory assistance in critically ill patients. A Mobile Remote Cardiac Assist unit was created to implant ECMO in patients from outside our institution and bring them back in our intensive care unit for follow-up when ...
Shiose Akira - - 2010
PURPOSE: This study evaluated the feasibility and efficacy of a newly developed adjustable left ventricular assist device inflow cannula in a short-term calf model. DESCRIPTION: In this inflow cannula, the angle between the cannula body and the inflow cannula tip can be altered extracorporeally by manipulating 2 externalized cables connected ...
Wiktor Dominik M - - 2010
Ventricular assist devices (VADs) and intra-aortic balloon pumps (IABPs) are important tools that provide hemodynamic support to patients in cardiogenic shock. The Impella Recover 2.5 is a percutaneous VAD that provides temporary circulatory support. We report the case of a patient who required the combined support of both an IABP ...
Joyce David L - - 2010
Advances in palliation of congenital heart disease have resulted in improved survival to adulthood. Many of these patients ultimately develop end-stage heart failure requiring left ventricular assist device implantation (LVAD). However, morphologic differences in the systemic ventricle of these patients require careful attention to cannula placement. We report on the ...
Lad Vidyadhar - - 2010
Acute hemodynamic collapse resulting in cardiogenic shock and impending end-organ failure is usually associated with certain death. The introduction of short-term mechanical circulatory support (MCS) devices offers potential therapy to these critically ill patients. The BVS 5000 device (ABIOMED Inc, USA) is widely used in the United States, but rarely ...
Baldwin J Timothy - - 2010
Ventricular assist devices (VADs) are used to bridge heart failure patients to transplantation, to allow their own hearts to recover, or as permanent ("destination") therapy. To date, the use of VADs has been limited to late-stage heart failure patients because of the associated device risks. In 2008, a National Heart, ...
Marella Punnaiah C - - 2011
The Impella Recover LP 2.5 (Abiomed, Danvers, MA, USA) is a ventricular assist device that is easily placed and has low adverse events. It helps unload myocardial demand and enables revascularization in patients who are otherwise at extreme risk for percutaneous coronary intervention (PCI). It breaks the cycle of cardiogenic ...
Patel-Raman Sonna M - - 2010
The development of ventricular assist devices (VADs) for the treatment of heart failure has been ongoing since the National Heart Lung and Blood Institute (NHLBI) initiated the artificial heart program in 1964. The primary goal was to develop VADs and total artificial hearts for both temporary (short-term) and long-term use. ...
Tanawuttiwat Tanyanan - - 2011
A 54-year-old left ventricular assist device (LVAD)-supported patient with mechanical prosthetic valves was planned for LVAD exchange using cardiac computed tomography(CCT) for preoperative evaluation. The CCT revealed massive thrombus in the ascending aorta. The surgery was done without thromboembolic complications. We reinforces the utility of CCT as a preoperative assessment ...
Meyns Bart P - - 2011
Objective: Full mechanical support with a left-ventricular assist device (LVAD) is generally limited to end-stage heart-failure patients. We have been studying the safety and efficacy of the partial support Synergy(®) Pocket Micro-pump as bridge-to-transplant in a less-sick group of patients as a prelude to a study of its use for ...
Dandel Michael - - 2011
Unloading-promoted reversal of heart failure (HF) allows long-term transplant-free outcome after ventricular assist device (VAD) removal. However, because few patients with chronic cardiomyopathy (CCM) were weaned from VADs (the majority only recently), the reliability of criteria used for weaning decisions to predict long-term post-weaning success is barely known. After 15 ...
Mizuno Tomohiro - - 2011
Left ventricular assist devices (LVADs) greatly support heart recovery, but recurrent heart failure after LVAD removal limits their use as 'a bridge to recovery'. The combination of LVADs and cell transplantation (CTx) is expected to be effective to improve the success rate of LVAD removal. We investigated the feasibility of ...
Pereira Naveen L - - 2010
The de novo development of myocarditis during left ventricular assist device support for dilated cardiomyopathy has not been previously described. We report a case of severe eosinophilic myocarditis associated with the use of leukotriene-receptor antagonist montelukast that developed during left ventricular assist device support accompanied by intra-device thrombus formation that ...
Maury Philippe - - 2010
We report the first case of percutaneous radio-frequency (RF) ablation procedure in a patient implanted with a HeartMate II left ventricular assist device for refractory heart failure. This procedure was performed for poorly tolerated recurrent atrial arrhythmias. No harmful consequence happened during or after the procedure despite the potential electromagnetic ...
Romano Matthew A - - 2010
Right ventricular failure (RVF) is a cause of major morbidity and mortality in the left ventricular assist device (LVAD) population. Many LVAD candidates have clinical or subclinical right ventricular (RV) dysfunction, and the perioperative period is fraught with insults that may provoke reactive pulmonary vascular hypertension and acute or chronic ...
Kukucka Marian - - 2011
Left ventricular assist device (LVAD) implantation is an established option for treatment of patients with end-stage heart failure, but outcome may be worsened by right ventricular failure. The aim of this study was to evaluate the acute effect of LVAD on right ventricular geometry and function and the pulmonary circulation. ...
Cohn William E - - 2011
In patients with refractory heart failure, aortic valve (AV) insufficiency or the presence of a prosthetic AV has been considered a relative contraindication to left ventricular assist device (LVAD) therapy. Nevertheless, we have successfully implanted LVADs in 5 patients with native AV insufficiency or an AV prosthesis by closing the ...
Crumpstone Theresa - - 2010
A 63-year-old man with a newly placed left ventricular assist device (LVAD) was emergently taken to the operating room for mediastinal exploration secondary to worsened LVAD output, hemodynamic instability, and organ hypoperfusion. Intraoperative transesophageal echocardiography showed the LVAD inflow cannula intermittently aspirating the atrial septal wall, resulting in occlusion of ...
Nathan Meena - - 2010
Ventricular noncompaction is a rare but well-documented cause of cardiomyopathy. This report presents a case of ventricular noncompaction diagnosed late in end-stage cardiac failure and malignant ventricular arrhythmia, which required an Abiomed biventricular assist device as a bridge to transplantation.
Jennings Douglas L - - 2010
Advanced heart failure continues to be a significant cause of morbidity and mortality in the US. Patients with advanced heart failure have a poor prognosis without cardiac transplantation. The use of left ventricular assist devices (LVADs) as destination therapy for these patients is therefore expected to increase in the coming ...
Birks Emma J - - 2010
Remodelling is the central feature that occurs in the progression of heart failure. However, unloading of the heart with a left ventricular assist device (LVAD) can lead to reversal of many of the remodelling changes even in patients with advanced heart failure. LVAD unloading can also lead to improved myocardial ...
Bryant Roosevelt R - - 2010
Since its initial application in the pediatric patient population, the Berlin Heart EXCOR ventricular assist device has become a widely accepted form of mechanical circulatory support in Europe and the USA. The versatility of the device makes it ideal for pediatric patients because it can be tailored to the size ...
Timms Daniel - - 2010
The ventricular assist device inflow cannulation site is the primary interface between the device and the patient. Connecting these cannulae to either atria or ventricles induces major changes in flow dynamics; however, there are little data available on precise quantification of these changes. The objective of this investigation was to ...
Yamane Takashi - - 2010
To facilitate research and development (R&D) and to expedite the review processes of medical devices, the Ministry of Health, Labor and Welfare (MHLW) and the Ministry of Economy, Trade and Industry (METI) founded a joint committee to establish guidance for newly emerging technology. From 2005 to 2007, two working groups ...
John Ranjit - - 2010
The discrepancy between the limited availability of donor hearts and the ever-increasing number of patients with heart failure has led to the increasing use of left ventricular assist devices (LVAD) as a bridge to transplant. One of the main complications inherent following institution of LVAD therapy is right ventricular (RV) ...
Goldfinger Judith Z - - 2010
Heart failure is a progressive disease with significant morbidity and mortality, but prognostication often is difficult. Many of the evidence-based therapies for heart failure provide symptomatic benefit, but may have intolerable side effects for patients with advanced disease. At the end of life, there is evidence of varying strengths for ...
Zimmerman Hannah - - 2010
A 25-year-old African-American woman developed shortness of breath 7 days after a spontaneous vaginal delivery. She was found by echocardiogram to have a left ventricular ejection fraction of 10% and was diagnosed with postpartum cardiomyopathy. Despite medical therapy including diuretics, an ace inhibitor, and a beta blocker, over the next ...
Ojha Shreesh - - 2010
To evaluate the cardioprotective potential of Inula racemosa in myocardial ischemic-reperfusion injury, Wistar male albino rats were randomly divided into four groups. The group I and II animals were administered saline orally {(sham, ischemia- reperfusion (I-R) control group)} and animals of group III and group IV received I. racemosa extract ...
Thompson Mark A - - 2010
Induced hypothermia, a therapy that recently gained the attention of a broad spectrum of US and international medical authorities for its neuroprotective benefits in post-cardiac arrest patients, may represent an underexplored therapeutic option in patients with severe cardiac failure by optimizing hemodynamics and augmenting cardiac contractility. The authors present the ...
De Luca Giuseppe - - 2010
Distal embolization is a relatively common complication in primary angioplasty and is associated with poor perfusion and higher mortality. The aim of this article is to critically review literature on thrombectomy devices to prevent distal embolization in patients undergoing primary angioplasty. Several manual and mechanical devices have been proposed. Although ...
Anderson Mark - - 2010
BACKGROUND: The mortality rate of patients experiencing acute myocardial infarction (AMI) complicated by cardiogenic shock remains high. After conventional therapies have failed, ventricular assist devices (VADs) have been used to bridge patients to recovery or transplantation. METHODS: A voluntary US registry was established to track all patients implanted with the ...
Engström Annemarie E - - 2010
Although coronary artery bypass grafting remains an important therapeutic option for patients with complex coronary artery disease, percutaneous coronary intervention strategies have become an established alternative. Nevertheless, treatment options for surgery-ineligible patients with complex coronary artery disease used to be limited, especially in patients with a reduced left ventricular function. ...
Chrysant George S - - 2010
The HeartMate II left ventricular assist device (LVAD) is a small axial-flow next-generation pump. Acute stoppage of this device is a potentially lethal complication. As these devices proliferate, many patients will be in areas remote to their implant center. Therefore, percutaneous stabilization of these patients before definitive surgical replacement could ...
Krishan Kewal - - 2010
Giant left atrium in a patient who requires heart transplantation not only poses a significant mortality risk due to compression effect on the surrounding intrathoracic structures but also leads to technical difficulties during transplantation, especially with the left atrial anastomosis. We discuss a case of a patient with a giant ...
Unosawa Satoshi - - 2010
We report here a successful case of recovery from cardiogenic shock resulting from ischemic cardiomyopathy, treated by using a left ventricular assist device (LVAD). The LVAD was successfully explanted at the time of simultaneous coronary artery bypass grafting and left ventricular restoration after recovery from end-organ dysfunction by LVAD support.
Unosawa Satoshi - - 2010
We report a 65-year-old man with fulminant myocarditis undergoing percutaneous cardiopulmonary support (PCPS) and left ventricular assist device (LVAD). PCPS and intra-aortic balloon pumping was initially introduced for cardiogenic shock in the emergency department. We switched to LVAD because cardiac function did not recover despite PCPS for 5 days. Cardiac ...
Bass John L - - 2010
OBJECTIVES: This study assessed the feasibility and efficacy of implanting a new nitinol device in the left atrial appendage (LAA) in a canine model. BACKGROUND: Left atrial thrombus occurs in the LAA in 90% of humans with nonvalvular atrial fibrillation (AF). METHODS: The Amplatzer Left Atrial Appendage Occluder Device now ...
1 2 3 4 5 6 7 8 9 10 >