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Liu Yi Y Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 15 Changle West Road, Xi'an, 710032, - - 2014
NLRP3 inflammasome is necessary for initiating acute sterile inflammation. Recent studies have demonstrated that NLRP3 inflammasome is up-regulated and mediates myocardial ischemia/reperfusion (MI/R) injury. However, the signaling pathways that lead to the activation of NLRP3 inflammasome by MI/R injury have not been fully elucidated. C57BL/6J mice were subjected to 30 min ...
Xia Jing-Gang JG 1Medical School of Chinese People's Liberation Army, Chinese PLA General Hospital, Beijing, China. 2Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China. 3Department of Pathophysiology, Chinese PLA General Hospital, Beijing. 4Department of Emergency, Chinese PLA General Hospital, Beijing, China. 5Deparment of pathology, Beijing Chest Hospital, Capital Medical University, Beijing, - - 2014
The present study examined whether atorvastatin, when used for pharmacological post-conditioning, attenuated myocardial ischemia-reperfusion (IR) injury in a manner similar to ischemic post-conditioning, that is, by inhibition of endoplasmic reticulum (ER) stress-related apoptosis. In the present study, markers for myocardial injury, infarct area, and hemodynamics, and indicators of ER stress ...
Hughes Bryan G BG Departments of Pediatrics and Pharmacology, Mazankowski Alberta Heart Institute/Cardiovascular Research Centre, University of Alberta, 4-62 HMRC, Edmonton, AB, T6G 2S2, - - 2014
Matrix metalloproteinase (MMPs) are long understood to be involved in remodeling of the extracellular matrix. However, over the past decade, it has become clear that one of the most ubiquitous MMPs, MMP-2, has numerous intracellular targets in cardiac myocytes. Notably, MMP-2 proteolyzes components of the sarcomere, and its intracellular activity ...
Cabrera-Fuentes H A HA Justus-Liebig University Giessen, Institute for Biochemistry, Giessen, - - 2014
Despite optimal therapy, the morbidity and mortality of patients presenting with an acute myocardial infarction (MI) remain significant. Extracellular RNA (eRNA), exposed after cell damage, serves as cofactor for coagulation proteases and cytokines thereby promoting their procoagulant and proinflammatory functions in vivo. Following myocardial ischemia/reperfusion (I/R) in mice or I/R induced ...
Yousif N N Colorado, Surgery, Colorado, United States of - - 2014
Myocardial ischemia and reperfusion (I/R)-induced tissue injury involve a robust inflammatory response. Our previous study found that TLR4-mediated MCP-1 production and monocytes accumulation contributes to the mechanism of myocardial injury following global myocardial I/R. Sialic acid binding Ig-like lectin receptors (Siglecs) have been implicated in the control of monocyte responses. ...
Asgeri Mehrdad M Department of Medicine, University Hospitals , Cleveland, Ohio , USA - - 2014
Objective: To examine the dose response of TNFα in an ex vivo rat model of myocardial ischemia reperfusion. Methods and Results: Seventy-two rat hearts were mounted on Langendorff apparatus and perfused with oxygenated Krebs-Henseleit solutions. Ischemia was induced by reducing the perfusate flow rate. During reperfusion, incremental doses of recombinant ...
von Elverfeldt Dominik D University Medical Center Freiburg, Freiburg, - - 2014
-Inflammation and myocardial necrosis play important roles in ischemia/reperfusion injury after coronary artery occlusion and recanalization. The detection of inflammatory activity and the extent of myocardial necrosis itself are of great clinical and prognostic interest. We developed a dual, non-invasive imaging approach using molecular magnetic resonance imaging (MRI) in an ...
Takahashi Masafumi M Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical - - 2014
We thank Mezzaroma, et al for their interest in our review article,(1)) which describes the critical role of NLRP3 inflammasomes in inflammatory responses and tissue remodeling after myocardial infarction (MI). Moreover, we congratulate them for developing a novel pharmacological inhibitor of NLRP3 inflammasomes. According to their report,(2)) they synthesized 16673-34-0 ...
Mezzaroma Eleonora E Department of Pharmacotherapy and Outcome, Virginia Commonwealth - - 2014
To the Editor:We read with great interest the review article by Takahashi on the role of the NLRP3 inflammasome in acute myocardial infarction (AMI).(1)) The author reviewed the recent literature evaluating the role of the NLRP3 inflammasome in an animal model of AMI pointing out that the inflammatory response in ...
Nguyen Bao A V BA Department of Cardiothoracic Surgery, NHLI, Hammersmith Hospital, Imperial College, London, - - 2014
Myocardial ischemic stress and early reperfusion injury in patients undergoing coronary artery bypass grafting (CABG) operated on using intermittent cross-clamp fibrillation (ICCF) are not presently known. The role of mini-cardiopulmonary bypass (mCPB) versus conventional CPB (cCPB) during ICCF has not been investigated. These issues have been addressed as secondary objective ...
De Hoog Vince C VC Laboratory of Experimental Cardiology, Dept. of Cardiology UMC Utrecht, The - - 2014
Early reperfusion is mandatory for the treatment of acute myocardial infarction. This process, however, also induces additional loss of viable myocardium, called ischemia-reperfusion (IR) injury. Complement activation plays an important role in IR injury, partly through binding of C5a to its major receptor (C5aR). We investigated the role of C5aR ...
Andreadou Ioanna I Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, - - 2014
Ischemic heart disease is one of the leading causes of morbidity and mortality worldwide. The development of cardioprotective therapeutic agents remains a partially unmet need and a challenge for both medicine and industry, with significant financial and social implications. Protection of the myocardium can be achieved by mechanical vascular occlusions ...
Lal Hind H Center for Translational Medicine and Cardiology Division, Temple University School of - - 2014
Coronary artery disease is the leading cause of death and disability worldwide. In patients with acute coronary syndromes, timely and effective myocardial reperfusion by percutaneous coronary intervention is the primary treatment of choice to minimize the ischemic injury and limit the size of the myocardial infarction (MI). However, reperfusion can ...
Zálešák M M Institute for Heart Research, Slovak Academy of Science, Bratislava, Slovak Republic. - - 2014
The aim of our study was to characterize resistance to ischemia/reperfusion (I/R) injury in Langendorff-perfused rat hearts and effectivity of ischemic preconditioning (PC) under condition of simulated acute hyperglycemia (SAHG) by perfusion of the hearts with Krebs-Henseleit (KH) solution with elevated glucose concentration (22 mmol/l). I/R injury was induced by ...
Liu Yu Y Department of Pathology, Physiology and Pathophysiology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, School of Basic Medical Sciences, Capital Medical University, No.10 Xitoutiao, You An Men, Beijing, 100069, - - 2014
Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a newly identified proangiogenic protein, which plays an important role in vascular disease and angiogenesis. However, its role in myocardial ischemia/reperfusion (I/R) injury remains unknown. This study investigated whether AGGF1 is involved in the pathogenesis of mouse myocardial I/R ...
Bon D D Inserm U1082, Poitiers F-86021, France ; université de Poitiers, faculté de Médecine et de Pharmacie, F-86034 Poitiers, - - 2014
In 1990's, use of machine perfusion for organ preservation has been abandoned because of improvement of preservation solutions, efficient without perfusion, easy to use and cheaper. Since the last 15 years, a renewed interest for machine perfusion emerged based on studies performed on preclinical model and seems to make consensus ...
Methner Carmen C Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, - - 2014
Recently it has been shown that the mitochondria-targeted S-nitrosothiol MitoSNO protects against acute ischaemia/reperfusion (IR) injury by inhibiting the reactivation of mitochondrial complex I in the first minutes of reperfusion of ischaemic tissue, thereby preventing free radical formation that underlies IR injury. However, it remains unclear how this transient inhibition ...
Toldo Stefano S Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, - - 2014
-Maintaining physiological levels of hydrogen sulfide (H2S) during ischemia is necessary to limit injury to the heart. Due to the anti-inflammatory effects of H2S, we proposed that the H2S donor, Na2S, would attenuate myocardial injury through upregulation of 'protective' microRNA (miR)-21 and suppression of the inflammasome, a macromolecular structure that ...
Gawande Ninad B NB 1Assistant Professor, Dept. of Forensic Medicine, Punjabrao Deshmukh Medical College & Hospital, Amravati 2Assistant Professor, Dept. of Forensic Medicine, Govt. Medical College & Hospital, Nagpur 3Professor of Forensic Medicine, and Dean, Vasantrao Naik Govt. Medical College & Hospital, - - 2014
Modern clinical management of the patients sustaining traumatic injuries and thermal burns has resulted in their longer survival, but the clinical and pathological effects of these traumatic injuries over the myocardium have been largely neglected. It is speculated that certain factors like the inflammatory and degenerative lesions of heart, prolonged ...
Alvarez P P Critical Care Unit, Hospital Clínico Metropolitano La Florida, Santiago, Chile; Faculty of Medicine, University Finis Terrae, Chile; Pathophysiology Program, Faculty of Medicine, University of Chile, - - 2014
Ischemia-reperfusion (IR) cycle in the myocardium is associated with activation of an injurious cascade, thus leading to new myocardial challenges, which account for up to 50% of infarct size. Some evidence implicates reactive oxygen species (ROS) as a probable cause of myocardial injury in prooxidant clinical settings. Damage occurs during ...
Zhang Anbin A Department of Rheumatology and Immunology, Xiangyan central hospital, Hubei University of Arts and - - 2014
Ischemia reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in myocardial IR injury. Necrostatin-1 (Nec-1) is a small molecule capable of inhibiting RIP1 kinase activity and attenuates inflammation-mediated tissue injury. In our study, hearts of C57BL/6 mice were flushed and stored ...
Liu Li L Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, - - 2014
Oxidative stress is mechanistically implicated in the pathogenesis of myocardial injury and the subsequent fibrogenic tissue remodeling. Therapies targeting oxidative stress in the process of myocardial fibrogenesis are still lacking and thus remain as an active research area in myocardial injury management. The current study evaluated the effects of a ...
Bainey Kevin R KR Mazankowski Alberta Heart Institute, Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, - - 2014
Prompt reperfusion therapy in acute myocardial infarction enhances clinical outcome. However, reperfusion itself may contribute to myocardial cell death. The current review outlines the multifocal mechanisms of reperfusion injury and focuses on understanding the potential role of each element and its contribution to the injury pattern inflicted upon the myocardium. ...
Masters Megan M Department of Physiology Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford OX1 3PT, UK. Electronic address: - - 2014
From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. The epicardium provides paracrine signals to nurture growth of the developing heart from mid-gestation, and epicardium-derived cells act as progenitors of numerous cardiac ...
Khaidakov Magomed M University of Arkansas for Medical - - 2014
Myocardial infarct size is determined by death of non-ischemic border zone cardiomyocytes caused by export of injury signals from the infarct zone. The countermeasures to limit infarct size, therefore, should be aimed at non-selective blocking of most, if not all, injury signals from entering non-ischemic cells. To test whether inhibition ...
Hu Gangying G Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan City, 430060, - - 2014
High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia-reperfusion (I/R) injury. B-type natriuretic peptide (BNP) postconditioning has been reported to reduce myocardial I/R injury. The present study investigated whether postconditioning of BNP could reduce myocardial I/R injury by inhibiting HMGB1 expression and the potential mechanisms ...
Kataoka Yoshiyuki Y Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
We examined the impacts of omentin on myocardial injury in a mouse model of ischemia/reperfusion (I/R), and explored its underlying mechanisms. Obesity is a major risk factor for ischemic heart disease. Omentin is a circulating adipokine that is downregulated by obesity. In patients who underwent successful reperfusion treatment after acute ...
Gao Ling - - 2014
Inhibition of matrix metalloproteinases-2 (MMP-2) activation renders cardioprotection from ischemia/reperfusion (I/R) injury, however, the signaling pathways involved have not been fully understood. Intermittent hypobaric hypoxia (IHH) has been shown to enhance myocardial tolerance to I/R injury via triggering intrinsic adaptive responses. Here we investigated whether IHH protects the heart against ...
Bromage Daniel I DI The Hatter Cardiovascular Institute, 67 Chenies Mews, London WC1E - - 2014
Alleviating myocardial injury associated with ST elevation myocardial infarction is central to improving the global burden of coronary heart disease. The chemokine stromal cell-derived factor 1α (SDF-1α) has dual potential benefit in this regard. Firstly, SDF-1α is up-regulated in experimental and clinical studies of acute myocardial infarction (AMI) and regulates ...
Matsushima Shouji S Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, NJ; Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Oxidative stress, the presence of reactive oxygen species (ROS) in excess of the antioxidant capacity in the heart induces myocardial damage, accumulation of which leads to ischemic heart disease and heart failure. NADPH oxidase (Nox) 2 and 4 are the major sources of O2(-) and H2O2 in the heart and ...
Rassaf Tienush T University Hospital Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstrasse 5, D-40225 Düsseldorf, - - 2014
Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI. Cardioprotection by MIF is likely to be a multifactorial phenomenon mediated by receptor-mediated signaling processes, intracellular ...
Dominguez-Rodriguez Alberto A Alberto Dominguez-Rodriguez, Department of Cardiology, Complejo Hospitalario Universitario de Canarias, 38320 Tenerife, - - 2014
In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results ...
Biccard Bruce M BM Perioperative Research Group, Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South - - 2014
To review the current evidence for detection and management of perioperative myocardial ischemia. Patients who sustain a myocardial injury after noncardiac surgery are predominantly asymptomatic. Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. Mortality from both cardiac and noncardiac causes is significant. Perioperative physicians should ...
Sapkota Ranjan R Department of Cardio-Thoracic and Vascular Surgery, Manmohan Cardio-Thoracic Vascular and Transplant Center, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal, - - 2014
Missile injuries to heart are one of the most severe penetrating chest injuries, and mostly fatal. The presentation in those who survive may be unusual and insidious. Pseudoaneurysms of the heart, usually sequel to myocardial infarction, may rarely present after penetrating cardiac wounds. Their management is a challenging one, and ...
Song Yanbin Y 1Xijing - - 2014
Plasma levels of adiponectin (APN) are significantly increased in patients with renal dysfunction and are inversely related to the risk of cardiovascular mortality. The present study was designed to determine the role of APN in myocardial ischemia/reperfusion (MI/R) injury in mice with renal failure, and delineate the underlying mechanisms. Renal ...
Tereshchenko Larisa G LG From the *Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD; †Whiting School of Engineering, Biomedical Engineering Department, The Johns Hopkins University, Baltimore, MD; and ‡The Emergency Medicine Department, Johns Hopkins Hospital, Baltimore, - - 2014
Timely detection of myocardial injury is essential for appropriate management of patients in emergency department (ED) evaluated for acute myocardial infarction. A novel electrocardiogram (ECG) metric, the Cardiac Electrical Biomarker (CEB), uses eigenvalue modeling of the 12-lead ECG and quantifies dipolar vs. multipolar forces. The goal of this project was ...
Gourine Andrey A Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; - - 2014
This review highlights the importance of neural mechanisms capable of protecting the heart against lethal ischemia/reperfusion injury. Increased parasympathetic (vagal) activity limits myocardial infarction, and recent data suggest that activation of autonomic reflex pathways contributes to powerful innate mechanisms of cardioprotection underlying the remote ischemic conditioning phenomena.
Liu Mingjie M The First Hospital of Jilin University, Changchun, Jilin 130000, China ; Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, - - 2014
To evaluate the cardioprotective effects of trapidil on myocardial ischemia-reperfusion injury (MIRI) in rabbits. Rabbits were subjected to 40 min of myocardial ischemia followed by 120 min of reperfusion. Blood for superoxide dismutase (SOD) and malondialdehyde (MDA) were estimated. At the end of reperfusion, the rabbits were sacrificed and the ...
Nisahan Balasingam B Registrar in Medicine, University Medical Unit, Teaching Hospital Jaffna, Sri - - 2014
Envenomation by the honey bee can cause multi-organ dysfunction as a result of toxic effects and may cause a severe anaphylactic reaction. Acute myocardial ischemia is an extremely rare complication of bee envenomation. We report a case of a 58-year-old woman with acute myocardial injury following massive bee envenomation.
Rohrbach Susanne S From the Institute of Physiology, Justus Liebig University - - 2014
Caloric restriction (CR) is the most reliable intervention to extend lifespan and prevent age-related disorders in various species from yeast to rodents. Short-term and long-term caloric restriction confers cardioprotection against ischemia/reperfusion injury in young and even in aged rodents. A few human trials suggest that caloric restriction has the potential ...
Robertson Sarah - - 2014
Clinical studies have now confirmed the link between short-term exposure to elevated levels of air pollution and increased cardiovascular mortality, but the mechanisms are complex and not completely elucidated. The present study was designed to investigate the hypothesis that activation of pulmonary sensory receptors and the sympathetic nervous system underlies ...
Du Xianjin X Department of Emergency, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, - - 2014
High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury. Preconditioning of exendin-4 (Ex), a glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial I/R injury. The current study investigated whether Ex postconditioning also attenuated myocardial I/R injury and the potential ...
Ebrahimi Hadi H Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
Reperfusion injury is one of the main reasons of cardiac disease morbidity. Phytopharmaceuticals are gaining importance in modern medicine of cardioprotection because of their multiplex capacity. The aim of this study was to investigate the effect of diosgenin on the inflammatory response induced by myocardial ischemia and reperfusion injury and ...
Zhang Min M Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, - - 2014
Cardiac troponin-I (cTnI) and -T (cTnT) are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention (PCI)-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. - - 2014
Ischaemia-reperfusion injury following acute myocardial infarctions (AMI) is an unavoidable consequence of the primary percutaneous coronary intervention (pPCI) procedure. A pivotal mechanism in ischaemia-reperfusion injury is the production of reactive oxygen species following reperfusion. The endogenous hormone, melatonin, works as an antioxidant and could potentially minimise the ischaemia-reperfusion injury. Given ...
Perman Sarah M - - 2014
Targeted temperature management (TTM) has been investigated experimentally and used clinically for over 100 years. The initial rationale for the clinical application of TTM, historically referred to as therapeutic hypothermia, was to decrease the metabolic rate, allowing the injured brain time to heal. Subsequent research demonstrated the temperature dependence of ...
Laurikka Antti A The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, - - 2014
Adipocytokines are hormones regulating energy metabolism and appetite and according to recent reports also inflammatory responses including ischaemia-reperfusion injury. Based on experimental data, we hypothesized that the levels of adipocytokines adiponectin, adipsin, leptin and/or resistin would correlate with myocardial injury, inflammation and oxidative stress during cardiac surgery. Thirty-two patients undergoing ...
Lim Han S HS 1Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide & Royal Adelaide Hospital, Adelaide, - - 2014
-Inflammation has been linked to the genesis of stroke in atrial fibrillation (AF) and is implicated in early recurrent arrhythmia after AF ablation. We aimed to define the time course of inflammation, myocardial injury and prothrombotic markers following radiofrequency (RF) ablation for AF and its relation to AF recurrence. -Ninety ...
Abrial Maryline M Inserm U1060, CarMeN Laboratory, Université Lyon 1, F-69373, Lyon, France. Electronic address: - - 2014
Roles of cardiac fibroblasts (CF) in the regulation of myocardial structure and function have been emphasized in the last decade. Their implications in pathophysiological aspects of chronic heart diseases such as myocardial remodelling and fibrosis is now well established; however their contribution to the acute phase of ischemia reperfusion injury ...
Harvey Kate L KL Department of Biomolecular and Sports Sciences, Coventry University, Cox Street, Coventry, CV1 5FB, - - 2014
Ipratropium bromide (a non-selective muscarinic antagonist) is widely prescribed for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Analyses of COPD patients, with underlying ischaemic heart disease (IHD), receiving anticholinergics, have indicated increased risk of severity and occurrence of cardiovascular events (including myocardial infarction, (MI)). The present study explored whether ...
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