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Gao Ling - - 2014
Inhibition of matrix metalloproteinases-2 (MMP-2) activation renders cardioprotection from ischemia/reperfusion (I/R) injury, however, the signaling pathways involved have not been fully understood. Intermittent hypobaric hypoxia (IHH) has been shown to enhance myocardial tolerance to I/R injury via triggering intrinsic adaptive responses. Here we investigated whether IHH protects the heart against ...
Bromage Daniel I DI The Hatter Cardiovascular Institute, 67 Chenies Mews, London WC1E - - 2014
Alleviating myocardial injury associated with ST elevation myocardial infarction is central to improving the global burden of coronary heart disease. The chemokine stromal cell-derived factor 1α (SDF-1α) has dual potential benefit in this regard. Firstly, SDF-1α is up-regulated in experimental and clinical studies of acute myocardial infarction (AMI) and regulates ...
Rassaf Tienush T University Hospital Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstrasse 5, D-40225 Düsseldorf, - - 2014
Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI. Cardioprotection by MIF is likely to be a multifactorial phenomenon mediated by receptor-mediated signaling processes, intracellular ...
Dominguez-Rodriguez Alberto A Alberto Dominguez-Rodriguez, Department of Cardiology, Complejo Hospitalario Universitario de Canarias, 38320 Tenerife, - - 2014
In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results ...
Biccard Bruce M BM Perioperative Research Group, Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South - - 2014
To review the current evidence for detection and management of perioperative myocardial ischemia. Patients who sustain a myocardial injury after noncardiac surgery are predominantly asymptomatic. Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. Mortality from both cardiac and noncardiac causes is significant. Perioperative physicians should ...
Sapkota Ranjan R Department of Cardio-Thoracic and Vascular Surgery, Manmohan Cardio-Thoracic Vascular and Transplant Center, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal, - - 2014
Missile injuries to heart are one of the most severe penetrating chest injuries, and mostly fatal. The presentation in those who survive may be unusual and insidious. Pseudoaneurysms of the heart, usually sequel to myocardial infarction, may rarely present after penetrating cardiac wounds. Their management is a challenging one, and ...
Song Yanbin Y 1Xijing - - 2014
Plasma levels of adiponectin (APN) are significantly increased in patients with renal dysfunction and are inversely related to the risk of cardiovascular mortality. The present study was designed to determine the role of APN in myocardial ischemia/reperfusion (MI/R) injury in mice with renal failure, and delineate the underlying mechanisms. Renal ...
Tereshchenko Larisa G LG From the *Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD; †Whiting School of Engineering, Biomedical Engineering Department, The Johns Hopkins University, Baltimore, MD; and ‡The Emergency Medicine Department, Johns Hopkins Hospital, Baltimore, - - 2014
Timely detection of myocardial injury is essential for appropriate management of patients in emergency department (ED) evaluated for acute myocardial infarction. A novel electrocardiogram (ECG) metric, the Cardiac Electrical Biomarker (CEB), uses eigenvalue modeling of the 12-lead ECG and quantifies dipolar vs. multipolar forces. The goal of this project was ...
Gourine Andrey A Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; - - 2014
This review highlights the importance of neural mechanisms capable of protecting the heart against lethal ischemia/reperfusion injury. Increased parasympathetic (vagal) activity limits myocardial infarction, and recent data suggest that activation of autonomic reflex pathways contributes to powerful innate mechanisms of cardioprotection underlying the remote ischemic conditioning phenomena.
Liu Mingjie M The First Hospital of Jilin University, Changchun, Jilin 130000, China ; Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, - - 2014
To evaluate the cardioprotective effects of trapidil on myocardial ischemia-reperfusion injury (MIRI) in rabbits. Rabbits were subjected to 40 min of myocardial ischemia followed by 120 min of reperfusion. Blood for superoxide dismutase (SOD) and malondialdehyde (MDA) were estimated. At the end of reperfusion, the rabbits were sacrificed and the ...
Nisahan Balasingam B Registrar in Medicine, University Medical Unit, Teaching Hospital Jaffna, Sri - - 2014
Envenomation by the honey bee can cause multi-organ dysfunction as a result of toxic effects and may cause a severe anaphylactic reaction. Acute myocardial ischemia is an extremely rare complication of bee envenomation. We report a case of a 58-year-old woman with acute myocardial injury following massive bee envenomation.
Robertson Sarah - - 2014
Clinical studies have now confirmed the link between short-term exposure to elevated levels of air pollution and increased cardiovascular mortality, but the mechanisms are complex and not completely elucidated. The present study was designed to investigate the hypothesis that activation of pulmonary sensory receptors and the sympathetic nervous system underlies ...
Rohrbach Susanne S From the Institute of Physiology, Justus Liebig University - - 2014
Caloric restriction (CR) is the most reliable intervention to extend lifespan and prevent age-related disorders in various species from yeast to rodents. Short-term and long-term caloric restriction confers cardioprotection against ischemia/reperfusion injury in young and even in aged rodents. A few human trials suggest that caloric restriction has the potential ...
Du Xianjin X Department of Emergency, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, - - 2014
High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury. Preconditioning of exendin-4 (Ex), a glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial I/R injury. The current study investigated whether Ex postconditioning also attenuated myocardial I/R injury and the potential ...
Ebrahimi Hadi H Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, - - 2014
Reperfusion injury is one of the main reasons of cardiac disease morbidity. Phytopharmaceuticals are gaining importance in modern medicine of cardioprotection because of their multiplex capacity. The aim of this study was to investigate the effect of diosgenin on the inflammatory response induced by myocardial ischemia and reperfusion injury and ...
Zhang Min M Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, - - 2014
Cardiac troponin-I (cTnI) and -T (cTnT) are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention (PCI)-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as ...
Perman Sarah M - - 2014
Targeted temperature management (TTM) has been investigated experimentally and used clinically for over 100 years. The initial rationale for the clinical application of TTM, historically referred to as therapeutic hypothermia, was to decrease the metabolic rate, allowing the injured brain time to heal. Subsequent research demonstrated the temperature dependence of ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. - - 2014
Ischaemia-reperfusion injury following acute myocardial infarctions (AMI) is an unavoidable consequence of the primary percutaneous coronary intervention (pPCI) procedure. A pivotal mechanism in ischaemia-reperfusion injury is the production of reactive oxygen species following reperfusion. The endogenous hormone, melatonin, works as an antioxidant and could potentially minimise the ischaemia-reperfusion injury. Given ...
Laurikka Antti A The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, - - 2014
Adipocytokines are hormones regulating energy metabolism and appetite and according to recent reports also inflammatory responses including ischaemia-reperfusion injury. Based on experimental data, we hypothesized that the levels of adipocytokines adiponectin, adipsin, leptin and/or resistin would correlate with myocardial injury, inflammation and oxidative stress during cardiac surgery. Thirty-two patients undergoing ...
Lim Han S HS 1Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide & Royal Adelaide Hospital, Adelaide, - - 2014
-Inflammation has been linked to the genesis of stroke in atrial fibrillation (AF) and is implicated in early recurrent arrhythmia after AF ablation. We aimed to define the time course of inflammation, myocardial injury and prothrombotic markers following radiofrequency (RF) ablation for AF and its relation to AF recurrence. -Ninety ...
Abrial Maryline M Inserm U1060, CarMeN Laboratory, Université Lyon 1, F-69373, Lyon, France. Electronic address: - - 2014
Roles of cardiac fibroblasts (CF) in the regulation of myocardial structure and function have been emphasized in the last decade. Their implications in pathophysiological aspects of chronic heart diseases such as myocardial remodelling and fibrosis is now well established; however their contribution to the acute phase of ischemia reperfusion injury ...
Harvey Kate L KL Department of Biomolecular and Sports Sciences, Coventry University, Cox Street, Coventry, CV1 5FB, - - 2014
Ipratropium bromide (a non-selective muscarinic antagonist) is widely prescribed for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Analyses of COPD patients, with underlying ischaemic heart disease (IHD), receiving anticholinergics, have indicated increased risk of severity and occurrence of cardiovascular events (including myocardial infarction, (MI)). The present study explored whether ...
Clarke Sophie J - - 2014
Coronary heart disease and type-2 diabetes are both major global health burdens associated with an increased risk of myocardial infarction (MI). Following MI, ischaemia-reperfusion injury (IRI) remains a significant contributor to myocardial injury at the cellular level. Research has focussed on identifying a strategy or intervention to minimise IRI to ...
Xie Min M University of Texas Southwestern Medical Center, Dallas, - - 2014
Reperfusion accounts for a substantial fraction of the myocardial injury occurring with ischemic heart disease. Yet, no standard therapies are available targeting reperfusion injury. Here, we tested the hypothesis that SAHA, a histone deacetylase (HDAC) inhibitor FDA-approved for cancer treatment, will blunt reperfusion injury. Twenty-one rabbits were randomized into 3 ...
Erbel Raimund R Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Hufelandstr. 55, D-45122 Essen, - - 2014
The year 2013 was rich of new developments in cardiology, and percutaneous coronary intervention (PCI) in particular. This overview article will focus on contributions in the following areas: training for PCI, appropriateness and indications; access site selection, risk scores, peri-procedural myocardial infarction; trial results and long-term follow-up; PCI for specific ...
Chung Hyemoon - - 2014
We sought to investigate the influence of the extent of myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute myocardial infarction (AMI). Thirty-eight reperfused AMI patients underwent cardiac magnetic resonance (CMR) imaging after percutaneous coronary revascularization. The extent of myocardial edema and scarring were ...
Li Bin B Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China; Department of Health care, Jinan Central Hospital affiliated to Shandong University, Jinan, Shandong, - - 2014
MicroRNA-7 (miR-7) is highly connected to cancerous cell proliferation and metastasis. It is also involved in myocardial ischemia-reperfusion (I/R) injury and is upregulated in cardiomyocyte under simulated I/R (SI/R). We aimed to investigate the role of miR-7 during myocardial I/R injury in vitro and in vivo and a possible gene ...
Prathep Sumidtra S 1Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA. 2Department of Neurological Surgery, University of Washington, Seattle, WA. 3Department of Pediatrics, University of Washington, Seattle, WA. 4Department of Radiology, University of Washington, Seattle, - - 2014
The aim of this study was to examine cardiac dysfunction during the first 2 weeks after isolated traumatic brain injury and its association with in-hospital mortality. Retrospective. Level 1 regional trauma center. Adult patients with severe traumatic brain injury. After institutional review board approval, data from adult patients with isolated ...
Sadoh Wilson E WE Department of Child Health, University of Benin/University of Benin Teaching Hospital, Benin City, - - 2014
Troponin T (cTnT) and Creatinine Kinase Isoenzyme (CK-MB) are both markers of myocardial injuries. However, CK-MB is also elevated in acute kidney injury. The diagnostic value of both cTnT and cardiac CK-MB in combined myocardial and acute kidney injuries (AKI) in asphyxiated neonates was evaluated. 40 asphyxiated infants and 40 ...
Meng Xiang-Yan XY Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin, China; Department of Physiology and Pathophysiology, Logistics University of Chinese People's Armed Police Force, Tianjin, - - 2014
ZFP580 is a novel C2H2 type zinc-finger transcription factor recently identified by our laboratory. We previously showed that ZFP580 may be involved in cell survival and growth. The aim of this study was to elucidate whether ZFP580 is involved in the cardioprotective effects of intermittent high-altitude (IHA) hypoxia against myocardial ...
Kasem Mohamed M Department of Cardiology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, - - 2014
A traumatic ventricular septal defect (VSD) resulting from blunt chest injury is a very rare event in children. The clinical symptoms and timing of presentation are variable, so diagnosis and management of traumatic VSD may be challenging. Decision to close the traumatic VSD is usually based on a combination of ...
Wybraniec Maciej M First Department of Cardiology, Medical University of Silesia, Upper Silesian Medical Centre in Katowice, Poland. Electronic address: - - 2013
Tako-tsubo syndrome pertains to rare acquired cardiomyopathies, characterized by left ventricular dyskinesia and symptomatology typical for acute myocardial infarction (AMI). Despite its low incidence and relatively benign course, stress cardiomyopathy should be thoroughly differentiated from AMI. The importance of tako-tsubo consists of the fact that its manifestation initially resembles AMI. ...
Stavrakis Stavros S 1Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, - - 2013
-Ablation of epicardial posteroseptal accessory pathways (EpiPSAP) requires ablation within the coronary venous system. We assessed the risk of coronary artery (CA) injury with radiofrequency ablation (RFA) within the coronary venous system as a function of the distance between the CA and ablation site. We also examined the efficacy and ...
Martindale Joshua J JJ Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, - - 2013
Myocardial ischemia/reperfusion (I/R) injury is a major clinical problem leading to cardiac dysfunction and myocyte death. It is widely held that I/R causes damage to membrane phospholipids, and is a significant mechanism of cardiac I/R injury. Molecular dissection of sarcolemmal damage in I/R, however, has been difficult to address experimentally. ...
Querejeta Roca Gabriela G 1 Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, - - 2013
Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, although the underlying mechanisms are not well understood. We aimed to determine whether more severe OSA, measured by the Respiratory Disturbance Index (RDI), is associated with subclinical myocardial injury and increased myocardial wall stress. A total of 1,645 participants ...
Li Qian Q a Department of Physiology, Hebei Medical University, Shijiazhuang 050017, - - 2014
The aim of this study was to investigate whether the mitochondrial permeability transition pore (MPTP) opening was involved in the protective effects of CB2 receptor against ischemia-reperfusion (I-R) injury. For this, isolated perfused rat hearts were subjected to 30 min global ischemia followed by 120 min reperfusion, and left ventricle ...
Yang Jian J Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, 443000, Hubei, - - 2013
MicroRNAs are extensively involved in the pathogenesis of major cardiovascular diseases by suppressing target gene expression. Recent studies have reported that microRNA-22 (miR-22) may be implicated in ischemia-reperfusion (I/R) induced myocardial injury. However, the specific function of miR-22 in myocardial I/R injury is far from clear nowadays. The present study ...
Kim Seok Jai SJ Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 671 Jebong-ro Donggu, Gwangju, 501-757, - - 2013
Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has been shown to modulate numerous molecular targets in the setting of inflammation. This study aimed to determine whether EGCG protects against regional myocardial ischemia/reperfusion (I/R) injuries and its underlying mechanisms involving the role of reperfusion injury salvage kinase (RISK) pathways ...
Langhorn Rebecca - - 2013
To investigate the presence of myocardial injury in dogs hospitalized for snake envenomation and to examine its relationship with systemic inflammation. Prospective case-control study. University teaching hospital and small animal referral hospital. Dogs naturally envenomed by the European viper (Vipera berus; n = 24), African puff adder (Bitis arietans; n ...
Macchi L - - 2013
Acute myocardial infarction is a leading cause of mortality and morbidity worldwide. Although essential for successful recovery, myocardium reperfusion is associated with reperfusion injury. Two major cell survival signaling cascades are known to be protective against ischemia-reperfusion (I/R) injury: the reperfusion injury salvage kinase (RISK), including Akt, ERK1/2 and the ...
Zhou Xue-Liang - - 2013
Ischemic postconditioning (IPost), able to significantly attenuate myocardial ischemia reperfusion injury, is dependent on RISK signaling. Studies have shown that Notch signaling repairs damaged myocardium, and this study aimed to investigate the effect of Notch signaling in myocardial IPost. We used H9c2 cells to establish the myocardial IPost and Hypoxia/Reoxygenation ...
Chen T-H - - 2013
Renal ischemia and reperfusion (I/R) injury frequently leads to acute renal failure (ARF) and multiple-organ injury with a substantial morbidity rate. The primary cause of ARF-associated death is, however, cardiac failure instead of renal failure itself, and the pathogenesis of renal I/R-induced cardiac injury is still poorly understood. We evaluated ...
Wu N-C - - 2013
Lung ischemia and reperfusion (I/R) injury is the major complication subsequent to cardiopulmonary bypass surgery and lung transplantation. Lung I/R injury frequently induces cardiac dysfunction leading to significant mortality. So far, the literature on therapeutic interventions in cardiac dysfunction and myocardial injury is still scarce. In this study, we examined ...
Coskun C - - 2013
CDP-choline exerts tissue protective effect in several ischemic conditions. Recently we have reported that the drug prevents cardiac arrhythmias and improves survival rate in short-term myocardial ischemia reperfusion in rats. In the current study, we determined the effect of intravenously administered CDP-choline on myocardial tissue injury induced by 30-min ischemia ...
Vemula P - - 2013
Myocardial Ischemia/Reperfusion (I/R) induced injury has widespread detrimental effects partially negating the benefits obtained from early revascularization in Acute Myocardial Infarction. Various complex mechanisms contribute to I/R injury and different agents targeting those specific mechanisms are being studied. Despite continued research and widespread interest, none of them have become incorporated ...
Povlsen Jonas Agerlund - - 2013
Reperfusion injury and its modulation are incompletely characterized. The purpose of the present study was to characterize the dynamics of reperfusion injury by portraying the temporal release of lactate dehydrogenase (LDH) during ischemia-reperfusion injury in an isolated heart model. We studied infarct size and LDH release in the following groups: ...
Song Lina - - 2013
12/15-Lipoxygenase (LOX) is a member of the LOX family that catalyzes the step from arachidonic acid to hydroxy-eicosatetraenoic acids (HETEs). Previous studies demonstrated that 12/15-LOX plays a critical role in the development of atherosclerosis, hypertension, heart failure, and other diseases; however, its role in myocardial ischemic injury was contraversal. Here, ...
Schmidt Michael R - - 2013
While remote ischemic preconditioning (rIPC) protects the mature heart against ischemia-reperfusion (IR) injury, the effect on the neonatal heart is not known. The neonatal heart relies almost solely on carbohydrate metabolism, which is modified by rIPC in the mature heart. We hypothesized that rIPC combined with metabolic support with glucose-insulin ...
Bernink F J P - - 2013
Reperfusion by means of percutaneous coronary intervention or thrombolytic therapy is the most effective treatment for acute myocardial infarction, markedly reducing mortality and morbidity. Reperfusion however induces necrotic and apoptotic damages to cardiomyocytes, that were viable prior to reperfusion, a process called lethal reperfusion injury. This process, consisting of many ...
Savchenko Alexander S AS Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, - - 2014
Innate immune cells play a major role in the early response to myocardial ischemia/reperfusion (MI/R) injury. Recombinant human ADAMTS13 (rhADAMTS13), cleaving von Willebrand factor (VWF), reduces leukocyte recruitment in mice. Death of cardiomyocytes and the possible formation of neutrophil extracellular traps (NETs) may result in chromatin release that is prothrombotic ...
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