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Du Jianhai - - 2013
We reported previously that Brown Norway (BN) rats are more resistant to myocardial ischemia/reperfusion (I/R) injury than are Dahl S (SS) rats. To identify the unique genes differentially expressed in the hearts of these rats, we used DNA microarray analysis and observed that enoyl coenzyme A hydratase-containing domain 2 (ECHDC2) ...
Yang Yang - - 2013
Peri-procedural myocardial injury, which is associated with worse long-term clinical outcome, is a common complication related to inflammatory pathogenetic mechanisms. Monocytes and macrophages play key roles in the initiation and progression of atherosclerosis. Recent studies have demonstrated that monocytes in human peripheral blood are heterogeneous, including CD14+CD16- monocytes and CD14+CD16+ ...
Wang Wang - - 2013
Coronary artery disease leading to myocardial ischemia is the most common cause of heart failure. Apelin (APLN), the endogenous peptide ligand of the APJ receptor, has emerged as a novel regulator of the cardiovascular system. Here we show a critical role of APLN in myocardial infarction (MI) and ischemia-reperfusion (IR) ...
Qiao Xin - - 2013
In this paper, we concluded that transient acidosis reperfusion conferred cardioprotection against myocardial ischemia reperfusion injury in isolated rat hearts through activating PI3K-Akt-eNOS pathway.
Rani Neha - - 2013
Naringin has antioxidant properties that could improve redox-sensitive myocardial ischemia reperfusion (IR) injury. This study was designed to investigate whether naringin restores the myocardial damage and dysfunction in vivo after IR and the mechanisms underlying its cardioprotective effects. Naringin (20-80 mg/kg/day, p.o.) or saline were administered to rats for 14 ...
Yiu Kai-Hang KH Division of Cardiology, Department of Medicine, the University of Hong Kong, Rm 1929b, Block K, Queen Mary Hospital, - - 2013
Type 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis may contribute to subclinical myocardial injury in patients with T2DM. Serum high-sensitivity troponin I (hs-TNI) an indicator of myocardial injury, was measured in ...
Hu Gangying - - 2013
High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury. Exendin-4 (Ex-4), glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial I/R injury. This study was to investigate the potential mechanism by which Ex-4 attenuates myocardial I/R injury in rats. Anesthetized ...
Liu Qing Q Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA ; The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, - - 2013
Myocardial ischemia-reperfusion (MIR) injury is a major contributor to the morbidity and mortality associated with coronary artery disease, which accounts for approximately 450,000 deaths a year in the United States alone. Chinese herbal medicine, especially combined herbal formulations, has been widely used in traditional Chinese medicine for the treatment of ...
de Haan J J JJ Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, Room G02.523, 3584 CX Utrecht, The - - 2013
During myocardial infarction, sterile inflammation occurs. The danger model is a solid theoretic framework that explains this inflammation as danger associated molecular patterns activate the immune system. The innate immune system can sense danger signals through different pathogen recognition receptors (PRR) such as toll-like receptors, nod-like receptors and receptors for ...
Mersmann Jan J Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, - - 2013
Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). However, the endogenous ligand responsible for TLR2 activation has not yet been detected. The objective of this study was to identify HMGB1 as an activator of TLR2 signalling during MI/R. C57BL/6 wild-type (WT) or TLR2(-/-)-mice ...
Hong Xuan X Department of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, - - 2013
Myocardial ischemia/reperfusion (MIR) injury easily occurrs during cardiopulmonary bypass surgery in elderly patients. In an attempt to develop an effective strategy, we employed a pig model of MIR injury to investigate the maximum rate of change of left ventricular pressure, left ventricular enddiastolic pressure, and left intraventricular pressure. Coronary sinus ...
Bao Weike W Metabolic Pathways and Cardiovascular Unit, GlaxoSmithKline Pharmaceuticals King of Prussia, PA, - - 2013
Thymosin beta 4 (Tβ4) was previously shown to reduce infarct size and improve contractile performance in chronic myocardial ischemic injury via two phases of action: an acute phase, just after injury, when Tβ4 preserves ischemic myocardium via antiapoptotic or anti-inflammatory mechanisms; and a chronic phase, when Tβ4 activates the growth ...
Sawicki Grzegorz G Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5 ; Department of Clinical Chemistry, Medical University of Wroclaw, Wrovasc Integrated Cardiovascular Centre, 50-556 Wroclaw, - - 2013
Much is known regarding cardiac energy metabolism in ischemia/reperfusion (I/R) injury. Under aerobic conditions, the heart prefers to metabolize fatty acids, which contribute to 60-80% of the required ATP. During ischemia, anaerobic glycolysis increases and becomes an important source of ATP for preservation of ion gradients. With reperfusion, fatty acid ...
Mozaffari Mahmood S MS Department of Oral Biology, College of Dental Medicine, Georgia Regents University Augusta, Georgia 30912, - - 2013
Coronary artery disease and associated ischemic heart disease are prevalent disorders worldwide. Further, systemic hypertension is common and markedly increases the risk for heart disease. A common denominator of systemic hypertension of various etiologies is increased myocardial load/mechanical stress. Thus, it is likely that high pressure/mechanical stress attenuates the contribution ...
Mokni Meherzia M Neurophysiology Laboratory and Functional Pathology, Department of Biological Sciences, Faculty of Sciences of Tunis, University Campus of Al-manar, Tunisia, - - 2013
In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, ...
Bell Robert M RM The Hatter Cardiovascular Institute, Institute of Cardiovascular Medicine, University College London, London, - - 2013
The mitochondrial permeability transition pore (mPTP) is widely accepted as an end-effector mechanism of conditioning protection against injurious ischaemia/reperfusion. However, death can be initiated in cells without pre-requisite mPTP opening, implicating alternate targets for ischaemia/reperfusion injury amelioration. Matrix metalloproteinases (MMP) are known to activate extrinsic apoptotic cascades and therefore we ...
DÄ…browski Marek Jerzy MJ Cardiology Clinic, Physiotherapy Division, 2 Faculty of Medicine, Bielanski Hospital, Medical University of Warsaw, - - 2013
Successful treatment of myocardial infarction related to early reperfusion therapy has caused growing interest in not only ischemic but also myocardial reperfusion injury. Most experimentally confirmed preservation myocardial reperfusion injury methods have failed in clinical practice. Probably one reason for their ineffectiveness was the very narrow "time window" necessitating application ...
Malliaras Konstantinos K Cedars-Sinai Heart Institute, Los Angeles, - - 2013
In recent years, several landmark studies have provided compelling evidence that cardiomyogenesis occurs in the adult mammalian heart. However, the rate of new cardiomyocyte formation is inadequate for complete restoration of the normal mass of myocardial tissue, should a significant myocardial injury occur, such as myocardial infarction. The cellular origin ...
Wei Guo - - 2012
Myocardial ischemia/reperfusion (MI/R) injury, in which inflammatory response plays a vital role, is frequently encountered in clinical practice. The present study was aimed to investigate the anti-inflammatory effect and the possible mechanism of protocatechuic aldehyde (PAl) on MI/R injury both in vivo and in vitro. The rat model of MI/R ...
Tritto Isabella - - 2012
No-reflow, i.e., the lack of distal myocardial perfusion to fully recover following recanalization of an acutely occluded coronary artery, is not only a mere consequence of ischemic injury, as substantial microvascular alterations may also develop subsequently, after initial restoration of perfusion. Since part of perfusion impairment is secondary to events ...
De Caterina Alberto R - - 2012
The pathophysiology of myocardial damage in the setting of ischemic cardiomyopathy is complicated by the fact that the process of restoring blood flow to the ischemic cardiomyocytes can itself induce injury to the myocardium. This phenomenon, termed reperfusion injury, reduces the benefits of vessel recanalization and contributes to the damage ...
Guarini Giacinta - - 2012
The advent of reperfusion therapy constituted a historical change for the management of myocardial infarction (MI) patients. However, shortly after, experimental models recognized an intrinsic damage, related to reperfusion itself, which was termed as ischemia-reperfusion injury (IRI). Clinical studies attribute IRI a significant burden of morbidity and mortality observed in ...
Mohanty I Ray - - 2012
The present study was undertaken to scientifically evaluate, validate and compare the cardioprotective effects of lisinopril (Lsp), an angiotensin converting enzyme (ACE) inhibitor and vitamin E (Vit E), an antioxidant in the setting of ischemia and reperfusion (I-R) injury. An open chest left anterior descending coronary artery occlusion and reperfusion ...
Shi Jingfei - - 2012
Around the world, stroke is the second most common cause of death and a major cause of disability. The main direct cause of stroke is the occlusion of intracranial artery, which leads to cell death in the core suffered region, or cell functional impairment surrounding the dead core (termed ischemic ...
Senyo Samuel E - - 2013
Although recent studies have revealed that heart cells are generated in adult mammals, the frequency of generation and the source of new heart cells are not yet known. Some studies suggest a high rate of stem cell activity with differentiation of progenitors to cardiomyocytes. Other studies suggest that new cardiomyocytes ...
Young Robert W - - 2012
Perioperative hyperoxia has been claimed to have a number of therapeutic advantages. However, in the setting of cardiac surgery and cardiopulmonary bypass (CPB), enthusiasm for its use has been tempered by concerns regarding the effect of high partial pressures of oxygen on cardiac, vascular, and respiratory function and the potential ...
Xu Tongda - - 2012
Myocardial ischemia often results in damaged heart structure and function, which can be restored through ischemia/reperfusion (I/R) in most cases. However, I/R can exacerbate myocardial ischemia reperfusion injury (IRI). Luteolin, a widely distributed flavonoid, a member of a group of naturally occurring polyphenolic compounds found in many fruits, vegetables and ...
Srichai Monvadi B - - 2012
OBJECTIVES: We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial injury. BACKGROUND: Edema-sensitive T2-weighted FSE cardiac magnetic ...
Lauver D Adam - - 2012
ABSTRACT: Reactive oxygen species (ROS) are a key mediator of myocardial reperfusion injury. Endogenous cellular defenses against ROS often become overwhelmed after ischemia and reperfusion. Therefore exogenous supplementation of various antioxidant compounds has been hypothesized to protect against reperfusion. Glutathione (GSH) is an important endogenous antioxidant that affords protection against ...
Donner Daniel G - - 2012
Obesity with associated metabolic disturbances worsens ischaemic heart disease outcomes, and rodent studies confirm obesity with insulin-resistance impairs myocardial resistance to ischemia-reperfusion (I-R) injury. However, effects of obesity per se are unclear, with some evidence for paradoxic cardioprotection (particularly in older subjects). We tested the impact of dietary obesity on ...
- - 2012
Treatment of acute ST-elevation myocardial infarction (STEMI) by reperfusion using percutaneous coronary intervention (PCI) or thrombolysis has provided clinical benefits; however, it also induces considerable cell death. This process is called reperfusion injury. The continuing high rates of mortality and heart failure after acute myocardial infarction (AMI) emphasize the need ...
Amani Mohammad - - 2013
Introduction: Ischemia/Reperfusion (IR) injury mainly causes the increase of enzymes involved in myocytes injury including CK-MB (creatine kinase-MB) isoenzyme and LDH (lactate dehydrogenase). Leakage of CK-MB isoenzyme and LDH from myocardial tissues to blood is indicator of acute myocardial infarction. The aim of this study was to assess the effect ...
Hiroi Toshihito - - 2012
AIMS: Transient receptor potential melastatin 2 (TRPM2) highly expressed in immunocytes is a Ca(2+)-permeable nonselective cation channel activated by oxidative stress. Myocardial ischemia/reperfusion (I/R) injury is characterized by acute inflammation associated with the augmentation of oxidative stress. We hypothesized that TRPM2 is implicated in the exacerbation of myocardial I/R injury.Methods ...
Nath Laura C - - 2012
Objective-To determine whether there is evidence of myocardial injury in horses with acute abdominal disease. Design-Prospective case series. Animals-18 healthy horses and 69 horses with acute abdominal disease. Procedures-18 healthy horses had been admitted to the hospital for investigation and were assigned to group 1. Horses examined for acute abdominal ...
Uetani Tadayuki - - 2012
This study sought to evaluate the associations between homeostatic indexes of insulin resistance (HOMA-IR) and post-procedural myocardial injury and clinical outcome after a percutaneous coronary intervention (PCI) with a drug-eluting stent. Insulin resistance increases the risk of cardiovascular events. However, the association between insulin resistance and clinical outcome after coronary ...
Wang Yun - - 2013
Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed to examine the effects of honokiol on myocardial I/R injury and to investigate its potential cardioprotective mechanisms. Sprague-Dawley rats were pretreated ...
Bleilevens C C Department of Anesthesiology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, - - 2013
Middle cerebral artery occlusion (MCAO) models have become well established as the most suitable way to simulate stroke in experimental studies. The high variability in the size of the resulting infarct due to filament composition, rodent strain and vessel anatomy makes the setup of such models very complex. Beside controllable ...
Itou Junji - - 2012
Adult zebrafish possess a significant ability to regenerate injured heart tissue through proliferation of pre-existing cardiomyocytes, which contrasts with the inability of mammals to do so after the immediate postnatal period. Zebrafish therefore provide a model system in which to study how an injured heart can be repaired. However, it ...
Pavlov Vasile I - - 2012
Coagulation disorders and reperfusion of ischemic myocardium are major causes of morbidity and mortality. Lectin pathway initiation complexes are composed of multimolecular carbohydrate recognition subcomponents and 3 lectin pathway-specific serine proteases. We have recently shown that the lectin pathway-specific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the ...
Grieve Stuart M - - 2012
Inflammatory response plays an important role in myocardial ischaemia-reperfusion (IR) injury. Up-regulation of vascular cell adhesion molecule-1 (VCAM) contributes to this. We examined the feasibility of using intravenously administered VCAM-MPIO (microparticle iron oxide) to characterize VCAM expression patterns in myocardial IR injury. Myocardial ischemia was simulated by 30 min of transient ...
Das Anindita A Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, USA. - - 2012
Rapamycin (Sirolimus®) is used to prevent rejection of transplanted organs and coronary restenosis. We reported that rapamycin induced cardioprotection against ischemia-reperfusion (I/R) injury through opening of mitochondrial K(ATP) channels. However, signaling mechanisms in rapamycin-induced cardioprotection are currently unknown. Considering that STAT3 is protective in the heart, we investigated the potential ...
Gandhi Chintan C Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, - - 2012
Epidemiologic studies suggest that elevated VWF levels and reduced ADAMTS13 activity in the plasma are risk factors for myocardial infarction. However, it remains unknown whether the ADAMTS13-VWF axis plays a causal role in the pathophysiology of myocardial infarction. In the present study, we tested the hypothesis that ADAMTS13 reduces VWF-mediated ...
Lim Sun Ha SH Department of Biochemistry, School of Medicine, Catholic University of Daegu, Daegu 705-718, - - 2012
Interruption of blood flow through coronary arteries and its subsequent restoration triggers the generation of a burst of reactive oxygen species (ROS), leading to myocardial cell death. In this study, we determined whether a methanol extract of Cassia mimosoides var. nomame Makino could prevent myocardial ischemia-reperfusion injury. When radical scavenging ...
Shekarforoush Shahnaz - - 2012
This study was carried out to determine the effects of cupping on hemodynamic parameters, arrhythmias and infarct size (IS) after myocardial ischemic reperfusion injury in male rats. Rats were randomly subjected to dry or wet cupping. While dry cupping simply involved stimulation of the skin by suction, in wet cupping, ...
Qin Chengxue - - 2012
BACKGROUND AND PURPOSE: Annexin-A1(ANX-A1) is an endogenous, glucocorticoid-regulated anti-inflammatory protein. The N-terminal derived peptide Ac-ANX-A1 (2-26) preserves cardiomyocyte viability, but the impact of ANX-A1-peptides on cardiac contractility is unknown. We now test the hypothesis that ANX-A1 preserves post-ischaemic recovery of left ventricular (LV) function. EXPERIMENTAL APPROACH: Ac-ANX-A1 (2-26) was administered ...
Jin Jianmei - - 2012
Purpose: The purpose of this study was to determine whether cyclophosphamide (CP) can decrease myocardial and systemic TNF-α expression and thus protects myocardial I/R injury. Methods: Open chest rats were subjected to 30 min of ischemia followed by 3h, 12h or 24h of reperfusion. Rats were divided into sham group, ...
Berg Ryan - - 2012
The no reflow phenomenon can happen during elective or primary percutaneous coronary intervention. This phenomenon is thought to be a complex process involving multiple factors that eventually lead to microvascular obstruction and endothelial disruption. Key pathogenic components include distal atherothrombotic embolization, ischemic injury, reperfusion injury, and susceptibility of coronary microcirculation ...
Takagi Kensuke - - 2012
BACKGROUND: FEW DATA ARE AVAILABLE REGARDING THE OPTIMAL REVASCULARIZATION STRATEGY FOR UNPROTECTED DISTAL LEFT MAIN CORONARY ARTERY (UDLM) IN-STENT RESTENOSIS (ISR).METHODS AND RESULTS: BETWEEN APRIL 2002 AND DECEMBER 2008, UDLM-ISR FOLLOWING DRUG-ELUTING STENT (DES) IMPLANTATION OCCURRED IN 92 OF 474 PATIENTS (19.4%). OF THESE, 8 (8.7%) WHO UNDERWENT A CORONARY ...
Vasaiwala Samip - - 2012
We compared the effectiveness of drug-eluting stents (DESs) to bare-metal stents (BMSs) in ostial lesions from an unrestricted patient cohort with 3-year follow-up. DESs have proved more effective at decreasing repeat revascularization rates compared to BMSs in patients with uncomplicated coronary artery disease. Whether DESs provide similar benefits in ostial ...
Sugga G S - - 2012
Prevention of myocardial injury has been considered as the most important therapeutic challenge of today. Fibrates, the agonists of the peroxisome proliferator-activated receptor (PPAR)-a receptor, have been regarded as potent therapeutic agents in this context. Hence, the present study has been designed to investigate the effect of fibrates, i.e., Clofibrate ...
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