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Results 201 - 250 of 1436
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Daly Michael W - - 2008
Recent concerns of adverse cardiac events associated with drugs used to treat attention-deficit-hyperactivity disorder (ADHD) have prompted debate over whether these drugs are truly safe. We describe a 17-year-old boy with a normal baseline echocardiogram who had been taking methylphenidate for ADHD for 18 months and experienced cardiac arrest. Emergency ...
Tsai Min-Shan - - 2008
OBJECTIVE: To compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls. DESIGN: Prospective animal study. SETTING: University-affiliated animal research laboratory. SUBJECTS: Twenty-four male domestic pigs. INTERVENTIONS: Ventricular fibrillation remained untreated for 10 mins after which animals were assigned into three groups: 1) intra-arrest ...
Sunde Kjetil - - 2008
BACKGROUND: Coronary heart disease is the most frequent cause of cardiac arrest. Return of spontaneous circulation is often not achieved during resuscitation due to the inability to restore coronary blood flow. OBJECTIVE: To review the literature with the aim of documenting if coronary angiography and subsequent percutaneous coronary intervention is ...
Huang Chien-Hua - - 2008
OBJECTIVE: Erythropoietin has been noted for its cardioprotective effects. The objective of the study is to investigate its effects on postresuscitation myocardial dysfunction and therapeutic windows. DESIGN: Randomized animal study. SETTING: Animal research laboratory. SUBJECTS: Adult male adult Wistar rats. INTERVENTIONS: Cardiopulmonary resuscitation was started after 6.5 or 9.5 mins ...
Wang Hao - - 2008
OBJECTIVE: Observational studies have shown that muscular stimulation contracting the thoracic cage may produce coronary perfusion pressures equal to manual chest compressions. This study examined electrical cardiopulmonary resuscitation for coronary perfusion pressures during ventricular fibrillation in a porcine model of cardiac arrest. DESIGN: Prospective randomized controlled study. SETTING: University affiliated ...
Koreny Maria - - 2009
AIMS: The Hypothermia after Cardiac Arrest (HACA) trial assessed whether mild therapeutic hypothermia improved the rate of good neurological recovery in patients after ventricular fibrillation cardiac arrest of presumed cardiac origin. We evaluated the impact of hypothermia on myocardial injury. METHODS: Re-analysis of a HACA trial subset for our department ...
Merchant Raina M RM The Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, United States. - - 2008
Indications for immediate cardiac catheterization in cardiac arrest survivors without ST elevation myocardial infarction (STEMI) are uncertain as electrocardiographic and clinical criteria may be challenging to interpret in this population. We sought to evaluate rates of early catheterization after in-hospital ventricular fibrillation (VF) arrest and the association with survival. Using ...
Nolan Jerry P - - 2008
AIM OF THE REVIEW: To review the epidemiology, pathophysiology, treatment and prognostication in relation to the post-cardiac arrest syndrome. METHODS: Relevant articles were identified using PubMed, EMBASE and an American Heart Association EndNote master resuscitation reference library, supplemented by hand searches of key papers. Writing groups comprising international experts were ...
Birati Edo Y - - 2008
OBJECTIVES: The only large-scale report (1988) by the Israeli national ambulance service Magen David Adom (MDA) on the outcome of cardiac arrest victims who underwent cardiopulmonary resuscitation (CPR) by paramedics called for more frequent and more promptly initiated CPR and shorter time to arrival of paramedic care to improve survival. ...
Adam Zulfiquar - - 2009
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether abdominal cardiopulmonary resuscitation (CPR) could be used instead of external cardiac massage either to protect the recent sternotomy or while chest compressions are not possible whilst a sternotomy is being performed. ...
Sy Jay C JC Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, - - 2008
Cardiac dysfunction following acute myocardial infarction is a major cause of death in the world and there is a compelling need for new therapeutic strategies. In this report we demonstrate that a direct cardiac injection of drug-loaded microparticles, formulated from the polymer poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK), improves cardiac function following ...
McLennan Stuart - - 2008
Cardiopulmonary resuscitation (CPR) is now the standard treatment for someone having a cardiac arrest. It is, however, a procedure that has emerged only relatively recently. For a number of scientific and religious reasons, it was long considered impossible, even blasphemous, to attempt to reverse 'death'. Because of these factors, the ...
Spinale Francis G FG Cardiothoracic Surgery, Strom Thurmond Research Center, 114 Doughty St, Suite 625, Charleston, SC 29425, - - 2008
Past studies have clearly established that matrix metalloproteinases (MMPs) contribute to adverse myocardial remodeling with ischemia and reperfusion. However, these studies measured MMP levels in extracted samples, and therefore whether and to what degree actual changes in interstitial MMP activity occur within the human myocardium in the context of ischemia/reperfusion ...
Kiss Gabor - - 2009
BACKGROUND: Cardiopulmonary resuscitation guidelines imply the use of epinephrine/adrenaline during cardiopulmonary arrest. However, in cardiac arrest situations resulting from coronary artery spasm (CAS), the use of epinephrine/adrenaline could be deleterious. METHODS AND RESULTS: A 49-year-old patient underwent an emergency coronarography with an attempt to stent the coronary arteries. Radiologic imaging ...
Chen Yih-Sharng - - 2008
OBJECTIVES: To evaluate the use of extracorporeal membrane oxygenation in prolonged cardiopulmonary resuscitation and to estimate how long cardiopulmonary resuscitation can be extended with acceptable results. DESIGN: Review of consecutive adult in-hospital cardiopulmonary resuscitation patients without return of spontaneous circulation in 10 mins and with extracorporeal membrane oxygenation rescue, and ...
Bahlmann Edda - - 2008
Tako-Tsubo Cardiomyopathy (TTC) is described as transient left ventricular (LV) dysfunction without coronary artery stenoses. Typically the onset of TTC-syndrome is following emotional or physical stress. As an acute cardiac syndrome it is mimicking ST-elevation myocardial infarction. In this case we report from a 73-year old woman presenting with cardiac ...
Hickey Robert W - - 2008
Outcomes from pediatric cardiac arrest and cardiopulmonary resuscitation (CPR) seem to be incrementally improving. The past 2 decades have brought advances in the understanding of the pathophysiology of cardiac arrest and ventricular fibrillation, better treatment strategies, and a more robust standard for CPR epidemiology and research reporting. The evolution of ...
Zideman David A - - 2008
Pediatric cardiac arrest is not a single problem. Although most episodes of pediatric cardiac arrest occur as complications and progressions of respiratory failure and shock, sudden cardiac arrest may result from sudden arrhythmias. With better understanding of the epidemiology of pediatric cardiac arrest, clinicians can better tailor therapy to optimize ...
Dare Leilah - - 2008
OBJECTIVE: The objective of this study was to determine whether a trained rescuer could teach untrained bystanders to perform basic life support (BLS) during a simulated cardiac arrest. METHOD: Volunteers were recruited from hospital ancillary staff and relatives of patients attending an emergency department. None had previous formal training in ...
Cubattoli Lucia - - 2009
A super-obese patient who suffered from severe sleep apnea (SSA) and other comorbidities underwent insertion of a BioEnterics intragastric balloon (BIB) before bariatric surgery. During the night, he was victim of cardiac arrest. After cardiopulmonary resuscitation and return of spontaneous circulation, he was transferred to intensive care unit. Two hours ...
Wu Meng-Yu - - 2008
BACKGROUND: Extracorporeal life support (ECLS) is associated with a high mortality rate in patients with preexisting multiple organ failure. To achieve better outcomes of ECLS in this high risk group, an understanding of the real impact of preexisting organ dysfunction on ECLS-associated mortality is necessary. METHODS: From January 2003 to ...
Marin-Neto Jose Antonio - - 2008
BACKGROUND: Benznidazole is effective for treating acute and chronic (recently acquired) Trypanosoma cruzi infection (Chagas' disease). Recent data indicate that parasite persistence plays a pivotal role in the pathogenesis of chronic Chagas' cardiomyopathy. However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is ...
Zaza Antonio - - 2008
The "late sodium current" (I(NaL)) is a sustained component of the fast Na+ current of cardiac myocytes and neurons. As recently appreciated, common neurological and cardiac conditions are associated with abnormal I(NaL) enhancement, which may contribute to the pathogenesis of both electrical and contractile dysfunction. For this reason, I(NaL) has ...
Lin Min - - 2008
The baroreflex control of heart rate (HR) is reduced following chronic intermittent hypoxia (CIH). Since the nucleus ambiguus (NA) plays a key role in baroreflex control of HR, we examined whether CIH remodels vagal efferent projections to cardiac ganglia. C57BL/6J mice (3-4 months of age) were exposed to either room ...
Janata Andreas - - 2008
AIM: Patients' outcomes after prolonged cardiac arrest are often grim. The aim of this study was to find the longest period of normovolemic, normothermic, cardiac arrest no-flow after which good neurologic outcome can be achieved with conventional therapies. METHODS: Swine (28-37 kg) were subjected to ventricular fibrillation cardiac arrest, after ...
Colquhoun M C - - 2008
BACKGROUND: Automated external defibrillators (AEDs) operated by lay persons are used in the UK in a National Defibrillator Programme promoting public access defibrillation (PAD). METHODS: Two strategies are used: (1) Static AEDs installed permanently in busy public places operated by those working nearby. (2) Mobile AEDs operated by community first ...
Lockowandt Ulf - - 2008
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether it is acceptable to delay cardiopulmonary resuscitation if a patient arrests after cardiac surgery in order to attempt defibrillation or pacing, prior to performing external cardiac massage. Altogether 550 papers were ...
Lequier Laurance - - 2008
OBJECTIVE: Comprehensive outcome assessment of children receiving cardiac extracorporeal life support. METHODS: From 2000 to 2004, 39 consecutive children (aged 1 day to 4.4 years) had cardiac extracorporeal life support. Neurodevelopmental follow-up of all survivors was performed more than 6 months after life support (aged 53 +/- 12 months). Developmental ...
Spöhr Fabian - - 2008
PURPOSE OF REVIEW: No specific drug therapy has been shown to improve long-term survival after cardiac arrest, and only few drugs have a proven benefit for short-term survival. This study reviews recent studies on drugs during cardiopulmonary resuscitation. RECENT FINDINGS: Epinephrine is the first-line vasopressor during cardiopulmonary resuscitation. Arginine vasopressin ...
Ahmed Aliya - - 2008
Introduction: Analysis of anesthesia related complications is important to identify the preventable causes and to make prevention strategies. Studies performed in various parts of the world (1-5) have examined perioperative cardiac arrests, with the main aim of improving quality. It is important to share such data, as insight into the ...
Berg Marc D - - 2008
The understanding of the incidence, epidemiology, etiology, and pathophysiology of pediatric cardiac arrest has evolved greatly in the past two decades. This includes recognition that cardiopulmonary resuscitation delays in cardiac arrest are especially injurious, ventricular arrhythmias are not as uncommon in children as previously believed, and four distinct phases of ...
Behringer Wilhelm - - 2008
PURPOSE OF REVIEW: The majority of cardiac arrest patients die after successful resuscitation. Despite disappointing survival rates, cardiac arrest research mainly focuses on new therapies applied during cardiac arrest in the out-of-hospital setting, but only little attention is given to therapies mitigating the so-called postresuscitation syndrome. Optimized postresuscitation hospital care ...
Noc Marko - - 2008
PURPOSE OF REVIEW: To review the evidence on urgent coronary angiography and percutaneous coronary intervention after resuscitated cardiac arrest and during ongoing cardiocerebral resuscitation. RECENT FINDINGS: In almost 450 patients with acute ST-elevation myocardial infarction after reestablishment of spontaneous circulation, success rate of primary percutaneous coronary intervention was 89%. Survival ...
Ellis Harold - - 2008
To operate on the abdominal aorta is difficult enough today, even with all the appurtenances of the modern operating theatre. Yet the first time this was performed, as an emergency by Astley Cooper of Guy's Hospital in 1817, it was carried out without any form of anaesthetic, in the patient's ...
Strauss Margit - - 2008
BACKGROUND: According to the current guidelines for acute myocardial infarction, ventricular fibrillation during the acute phase of myocardial infarction is no indication for specific treatment like ICD implantation. Primary objective of our study was to evaluate the prognostic significance of cardiac arrest within the acute phase of myocardial infarction in ...
Morrison Laurie J LJ Prehospital and Transport Medicine Research Program, Sunnybrook & Women's College Health Sciences Centre, 2075 Bayview Avenue, Suite C753, Toronto, Ontario, Canada M4N 3M5. - - 2008
To describe the development, design and consequent scientific implications of the Resuscitation Outcomes Consortium (ROC) population-based registry; ROC Epistry-Cardiac Arrest. The ROC Epistry--Cardiac Arrest is designed as a prospective population-based registry of all Emergency Medical Services (EMSs)-attended 9-1-1 calls for patients with out-of-hospital cardiac arrest occurring in the geographical area ...
Hayakawa Mineji - - 2008
To investigate the relationship between the inflammatory responses and postresuscitation syndrome, we prospectively examined the serial changes of neutrophil elastase (NE), urinary trypsin inhibitor (UTI), and TNF-alpha) in successfully resuscitated patients after out-of-hospital cardiac arrest. This study included 36 patients with out-of-hospital cardiac arrests who were admitted to our intensive ...
Chang Jui-Chih - - 2008
The authors propose a new method for total arch replacement under normothermic beating heart surgery. The surgical procedure was performed with no time limit. The cardiopulmonary bypass was terminated without using inotropic agents. The patient regained consciousness in postoperative hour 8 without any neurologic deficit. This new strategy avoids the ...
Collins Tim J - - 2008
This paper aims to undertake a review on the current evidence available on therapeutic hypothermia (TH) following cardiac arrest. The use of TH has been associated as a potential treatment for a number of medical conditions including head injury and cerebral vascular accidents. Within the past decade, there have been ...
Nichol Graham - - 2008
The 2010 impact goal of the American Heart Association is to reduce death rates from heart disease and stroke by 25% and to lower the prevalence of the leading risk factors by the same proportion. Much of the burden of acute heart disease is initially experienced out of hospital and ...
Falkensammer Christine B - - 2008
Cardiac malposition is a rare but important finding when detected on fetal ultrasound. The purpose of this study was to evaluate the incidence of fetal cardiac malposition, associated abnormalities, and clinical outcome in a tertiary-care medical center. Records of fetuses (1993 to 2006) with dextroposition, dextrocardia, mesocardia, ectopia cordis, or ...
Smith Hugh M - - 2008
BACKGROUND: Transfusion-associated hyperkalemic cardiac arrest is a serious complication of rapid red blood cell (RBC) administration. We examined the clinical scenarios and outcomes of patients who developed hyperkalemia and cardiac arrest during rapid RBC transfusion. METHODS: We retrospectively reviewed the Mayo Clinic Anesthesia Database between November 1, 1988, and December ...
Bardy Gust H - - 2008
BACKGROUND: The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use of an automated external defibrillator (AED) might offer an opportunity to improve survival for patients at risk. METHODS: We randomly assigned ...
Bohn Andreas - - 2008
PURPOSE OF REVIEW: Current cardiopulmonary resuscitation guidelines emphasize that providing high-quality basic life support is the single most important contribution to successful resuscitation. Efficiency of advanced cardiac life support depends on sufficient cardiopulmonary resuscitation performance leading to continuous bloodflow and oxygenation. Existing data show that the quality of cardiopulmonary resuscitation ...
Ostermann M - - 2008
Hemodialysis patients have significant cardiac-related mortality. Sudden cardiac arrests in the dialysis unit are infrequent events but carry a poor prognosis. The predominant rhythm is ventricular tachycardia/fibrillation. Although the exact etiologies are not clear, several studies have confirmed an increased incidence on the first day after the weekend interval. Use ...
Gonzalez Maria M - - 2008
BACKGROUND: The effect of prearrest left ventricular ejection fraction (LVEF) on outcome after cardiac arrest is unknown. METHODS AND RESULTS: During a 26-month period, Utstein-style data were prospectively collected on 800 consecutive inpatient adult index cardiac arrests in an observational, single-center study at a tertiary cardiac care hospital. Prearrest echocardiograms ...
Kern Karl B KB Sarver Heart Center, University of Arizona College of Medicine, 1501 N. Campbell, Tucson, AZ 85724, USA. - - 2008
Increases in serum cytokines have been reported after successful resuscitation from prolonged ventricular fibrillation (VF). Pro-inflammatory cytokines can stimulate inducible nitric oxide synthase (iNOS) to produce excessive levels of nitric oxide (NO). High levels of both myocardial inflammatory cytokines and nitric oxide levels can depress myocardial contractile function. We hypothesized ...
Chew K S - - 2008
Despite the progresses made in the science of cardiopulmonary resuscitation, there is lack of published works on this area in the Malaysian context. This survey was done to look at the outcomes of all cardiopulmonary resuscitation performed in Emergency Department (ED), Hospital Universiti Sains Malaysia (HUSM). This is a one ...
Brown Kate L - - 2008
Cardiac extra-corporeal life support is used more frequently in the current era of complex, high-risk neonatal heart surgery. Although outcome for neonates with complex heart disease has improved in the last decade, thanks to advances in surgery and intensive care, survival in the subset that require extra-corporeal support remains unchanged ...
Yu Alfred H - - 2008
During cardiac arrest emergencies, lay rescuers are required to manually check the patient's carotid pulse after the delivery of defibrillation shocks to assess the cardiac resuscitation progress of the patient. As a more automated way of monitoring the resuscitation progress, a new Doppler-ultrasound-based carotid pulse assessment approach is presented in ...
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