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Yamac Aylin Hatice AH Department of Cardiology, Bezmialem Foundation University, Istanbul, Turkey. Electronic address: - - 2014
We present a case of a middle-aged male patient who was admitted to our institution because of the supposed diagnosis of endocarditis/myocarditis. Echocardiographic findings revealed cystic mass in the left myocardial wall as well as floating structures at the lateral papillary muscle, mimicking endocarditis/myocarditis. Due to progressive urinary retention and ...
Shukla Rakesh R Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, - - 2014
We report the case of a 54-year-old hypertensive woman who presented with sudden onset left hemiparesis with facial asymmetry and inability to pass urine. Her bladder was distended and she had to be catheterised. MRI of her brain showed a large infarct in the right pontine region. Antiplatelet therapy was ...
Tannenbaum Cara C Faculties of Medicine and Pharmacy, Université de Montréal, Montreal, QC, - - 2013
Up to 50 % of heart failure patients suffer from lower urinary tract symptoms. Urinary incontinence has been associated with worse functional status in patients with heart failure, occurring three times more frequently in patients with New York Heart Association Class III and IV symptoms compared with those with milder disease. ...
Hu Wen - - 2012
Cardiac hemangiomas represent 1 to 2% of all detected benign heart tumors. Tumors in the coronary sinus have been reported; however, to our knowledge, there have been no reports of masses in a persistent left superior vena cava. We report here the first case of a 58-year-old man with a ...
Yağci-Küpeli Begül - - 2012
AIM: To detect subtle changes in myocardial function in pediatric cancer patients treated with high dose anthracyclines. METHODS: In all, 19 pediatric cancer patients with no cardiotoxicity findings treated with a cumulative anthracycline dose of ≥350 mg/m(2) and healthy participants of the same age were included in the study. Transthoracic echocardiography ...
Tsiamis Eleutherios E First Department of Cardiology, Hippokration Hospital, University of Athens, - - 2012
Capecitabine is a new oral chemotherapeutic agent that is considered highly specific for sensitive tumor cells. We present the case of a patient who, after treatment with capecitabine for colorectal cancer, presented to our hospital with angina pectoris and electrocardiographic changes indicative of myocardial ischemia. The absence of epicardial coronary ...
Konski Andre - - 2012
To determine factors associated with symptomatic cardiac toxicity in patients with esophageal cancer treated with chemoradiotherapy. We retrospectively evaluated 102 patients treated with chemoradiotherapy for locally advanced esophageal cancer. Our primary endpoint was symptomatic cardiac toxicity. Radiation dosimetry, patient demographic factors, and myocardial changes seen on (18)F-FDG PET were correlated ...
Piotrowski Grzegorz - - 2012
Trastuzumab, a recombinant humanized monoclonal antibody, is targeted against the external domain of the human epidermal growth factor receptor type 2 (HER2). It improves efficacy of HER2-positive breast cancer treatment. The authors present their experience with patients (pts) treated with trastuzumab in the aspects of cardiac complications. We observed prospectively ...
Gokay Seher - - 2012
Although newer cancer treatments and supportive care treatments have led to vast improvements in the management of complications associated with cancer treatment, sometimes they might cause serious side effects such as coronary artery disease, myocardial infarction and heart failure. These complications may occur any time during or after chemotherapeutics. In ...
Hatakenaka Masamitsu - - 2012
PURPOSE: To evaluate acute cardiac effects of concurrent chemoradiotherapy (CCRT) for esophageal cancer. METHODS AND MATERIALS: This prospective study was approved by the institutional review board, and written informed consent was obtained from all participants. The left ventricular function (LVF) of 31 patients with esophageal cancer who received cisplatin and ...
Trouvé Pascal - - 2012
The level of circulating anxA5 is correlated to various diseases such as acute myocardial infarction, trauma, thrombosis, inflammation and in some cancers. Our aim was to assess whether a direct approach using surface plasmon resonance (SPR) could be easily used to provide a rapid and cheap alternative to detect anxA5 ...
Voltolini L - - 2012
Recent studies have reported a high incidence of perioperative in-stent trombosis with myocardial infarction (MI), in patients undergoing non-cardiac surgery, early after coronary angioplasty and stenting. The short and long-term results of surgery for non-small cell lung cancer (NSCLC) after prophylatic coronary angioplasty and stenting were analyzed. Prospective collected data ...
Topolnjak Rajko - - 2012
PURPOSE: To quantify the geometrical uncertainties for the heart during radiotherapy treatment of left-sided breast cancer patients and to determine and validate planning organ at risk volume (PRV) margins. METHODS AND MATERIALS: Twenty-two patients treated in supine position in 28 fractions with regularly acquired cone-beam computed tomography (CBCT) scans for ...
Lange Stefan A - - 2012
Recent studies in breast cancer patients and Trastuzumab therapy (Herceptin) showed a development of a toxic cardiomyopathy as a severe complication. The aim of this study was to discover early changes in cardiac function and morphology. We studied 42 female patients with Her-2/-neu over-expression in breast cancer by echocardiography before, ...
Ito Daisuke - - 2012
Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cisplatin-based chemotherapy, has been limited. Case 1 with postoperative gastric cancer developed acute myocardial ...
Oliveira Sílvia Marta - - 2012
Cardiac metastases are more common than primary tumors. Several types of malignant tumors have been reported to metastasize to the heart, mainly lung cancer, but in the setting of esophageal cancer, myocardial metastasis is comparatively rare. We report a case of a cardiac metastasis from esophageal squamous cell carcinoma detected ...
Kumar Simi - - 2012
Doxorubicin, an anthracycline antibiotic commonly used as a chemotherapeutic agent for breast cancer, is well known to cause cardiotoxicity. We report the case of an active, otherwise healthy 57-year-old breast cancer survivor who, 17 years after chemotherapy, presented with symptoms of overt heart failure. She had no cardiac risk factors, ...
Klement Giannoula L - - 2012
The HER2-PI3K pathway is the one of the most mutated pathways in cancer. Several drugs targeting the major kinases of this pathway have been approved by the Food and Drug Administration and many are being tested in clinical trials for the treatment of various cancers. However, the HER2-PI3K pathway is ...
Meade Tom T Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. - - 2012
In those who have already survived myocardial infarction (MI) or stroke, or have had a transient ischaemic episode (TIA), daily low dose aspirin (ASA) reduces the risk of recurrences by an amount that greatly exceeds the risk of serious bleeding (secondary prevention). ASA is therefore recommended for these people. However, ...
Cardinale Daniela - - 2011
Abstract Cardiotoxicity is a serious adverse effect of anticancer drugs, impacting on quality of life and overall survival of cancer patients. According to the current standard for monitoring cardiac function, cardiotoxicity is usually detected only when a functional impairment has already occurred, precluding any chance of preventing its development. Over ...
Tzonevska Antonia - - 2011
The most severe side effect in breast cancer patients, treated with chemotherapy and/or radiotherapy is cardiotoxicity, leading to chronic heart failure and worsening the quality of life. The aim of our study was to detect early in these patients signs of cardiotoxicity. Twenty four breast cancer patients were included in ...
Tanindi Asli - - 2011
AIMS: Although systolic and diastolic left ventricular functions after cancer chemotherapy are well studied, there are a few investigations about the right ventricular functions. We aimed to investigate the early effects of chemotherapy on right heart, if any, in addition to the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and ...
Shah Nirali N - - 2011
Cardiac metastasis and hypertrophic osteoarthropathy are both quite rare. We describe a patient presenting with hypertrophic osteoarthropathy as the first symptom of recurrent infantile fibrosarcoma (IF). During surgical resection of lung metastasis, the patient suffered sudden cardiac arrest. Autopsy demonstrated a metastatic lesion in the intraventricular septum of the heart, ...
Catford Sarah R - - 2011
Cardiac metastasis from epithelial thyroid cancer is a very rare and potentially serious complication. We have identified only 54 reported cases over a 130-year period. Here we review this literature. Cardiac metastases are frequently asymptomatic, but when symptoms develop these tend to be severe and often fatal. The prognosis of ...
Roy Partha Pratim - - 2011
Bronchogenic carcinoma commonly metastasises to liver, bone, brain and adrenals. Involvement of mediastinal structures like superior vena cava, recurrent laryngeal nerve, phrenic nerve, pericardium, etc, is also common. But invasion of myocardium is very rare in bronchogenic carcinoma. A rare case of lung cancer with invasion to left atrium and ...
Sawaya Heloisa - - 2011
Chemotherapy-induced cardiotoxicity has become a significant public health issue. Left ventricular ejection fraction is routinely used to monitor cardiotoxicity but fails to detect subtle alterations in cardiac function. Improvements in the measurement of left ventricular ejection fraction, physical or pharmacologic stressors, and novel cardiac functional indices may be useful in ...
Alsaid Hasan - - 2011
The temporal evolution of heart failure and associated pulmonary congestion in rodent heart failure models has not yet been characterized simultaneously and noninvasively. In this study, MRI was used to assess the serial progression of left-ventricular dysfunction and lung congestion in mice following myocardial infarction (MI). Cardiac and lung (1) ...
Taillard Véronique - - 2011
Objective:  L-Thyroxine suppressive therapy benefits high-risk differentiated thyroid cancer patients by decreasing recurrence rates, and cancer-related mortality. However, fully suppressed serum TSH implies a state of subclinical hyperthyroidism (SCH) with associated adverse cardiac effects. Because left ventricular (LV) diastolic dysfunction may be the first manifestation of more severe LV failure, ...
Geisberg C A - - 2011
Trastuzumab is a monoclonal antibody to the ErbB2 (Her2nue) receptor over-expressed in Her2(+) breast cancer. Trastuzumab-related cardiotoxicity has revealed the importance of ErbB2 signaling in the heart. Neuregulin (NRG-1) is an important stress-mediated paracrine growth factor that signals through the family of ErbB receptors to promote cardioprotection (myocyte cell survival, ...
Witteles Ronald M - - 2011
Cardiotoxicity remains the limiting factor for many forms of cancer therapy and is the focus of growing research and clinical emphasis. This article outlines the current clinical evidence for left ventricular dysfunction and heart failure for the two most important classes of cardiotoxic chemotherapeutic agents, examines the potential pitfalls that ...
Yeo L - - 2011
To describe a novel and simple technique—simple targeted arterial rendering (STAR)—to visualize the fetal cardiac outflow tracts from dataset volumes obtained with spatiotemporal image correlation (STIC) and applying a new display technology (OmniView). We developed a technique to image the outflow tracts by drawing three dissecting lines through the four-chamber ...
Neukamm Christian - - 2011
Background: In five patients, an apical muscular septal defect was closed in a hybrid approach using the Amplatzer® duct occluder during open heart surgery, whereas concomitant defects were treated surgically. In addition to their different heart defects that needed surgery, all had a muscular ventricular septal defect in the apex ...
Fang Fang - - 2011
Background: Accurate diagnosis of crisscross heart and its associated anomalies is important but problematic for cardiologists. This study aimed at identifying unique transthoracic echocardiographic features and common associated lesions of this complex condition. Method: Clinical and echocardiographic features of 10 patients with crisscross anatomy were studied. Echocardiographic findings were verified ...
Hoashi Takaya - - 2011
Primary biventricular repair for left ventricular outflow tract obstruction and ventricular septal defect remains challenging. The intermediate-term outcomes and risk factors for mortality remain undefined. All patients undergoing primary biventricular repair of left ventricular outflow tract obstruction and ventricular septal defect from 1995 to 2008 at the C. S. Mott ...
Mizumura Kenji - - 2011
A 34-year-old woman visited our hospital with chest pain and was diagnosed with acute myocardial infarction (AMI) on admission. Echocardiography imaging revealed the presence of complex masses in the aortic valve. As serum tumor marker CA19-9 was elevated, she was screened for malignant disease. A computed tomography (CT) scan revealed ...
Shukla Praphulla C - - 2011
The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored. Here we show a new role for BRCA1 as a gatekeeper of cardiac function and survival. In mice, loss of BRCA1 in cardiomyocytes results ...
Subbiah Ishwaria M - - 2011
Vascular-disrupting agents (VDAs) represent a new class of chemotherapeutic agent that targets the existing vasculature in solid tumors. Preclinical and early-phase trials have demonstrated the promising therapeutic benefits of VDAs but have also uncovered a distinctive toxicity profile highlighted by cardiovascular events. We reviewed all preclinical and prospective phase I-III ...
Siragy Helmy M - - 2011
The safety of angiotensin II receptor blockers (ARBs) for the treatment of hypertension and cardiovascular and renal diseases has been well documented in numerous randomized clinical trials involving thousands of patients. However, recent concerns have surfaced about possible links between ARBs and increased risks of myocardial infarction and cancer. Less ...
Pituskin Edith - - 2011
MANTICORE 101 - Breast (Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research) is a randomized trial to determine if conventional heart failure pharmacotherapy (angiotensin converting enzyme inhibitor or beta-blocker) can prevent trastuzumab-mediated left ventricular remodeling, measured with cardiac MRI, among patients with HER2+ early breast cancer. One hundred and ...
Soto-Matos Arturo - - 2011
Plitidepsin is a cyclic depsipeptide of marine origin in clinical development in cancer patients. Previously, some depsipeptides have been linked to increased cardiac toxicity. Clinical databases were searched for cardiac adverse events (CAEs) that occurred in clinical trials with the single-agent plitidepsin. Demographic, clinical and pharmacological variables were explored by ...
Oreglia Jacopo A - - 2010
Iatrogenic coronary fistula is a rare condition whose treatment strategy is not well established. We report the case of a 70-year-old patient who came to our attention with echocardiographic and scintigraphic signs of myocardial ischemia and who had undergone heart transplantation 10 years earlier. The coronary angiogram showed a coronary ...
Zhu Da - - 2010
Transesophageal echocardiogram (TEE) guided perventricular cardiac intervention has gained popularity in recent years. We present a special case of perventricular closure conducted for a traumatic apical muscular ventricular septal defect (mVSD) under the guidance of three-dimensional (3D) TEE with an Amplatzer mVSD occluder and further discuss the important role of ...
Imai-Compton Carolin - - 2010
Double outlet left ventricle (DOLV) is a rare cardiac malformation in which both great arteries originate from the morphological left ventricle. There are limited data regarding the anatomical spectrum, characteristics and outcomes of DOLV. All patients with DOLV between 1960 and 2008 were identified. Patients' presentation, anatomy, surgical history, and ...
Zamani Jalal - - 2010
The combination of posttraumatic coronary artery-right ventricular fistula and multiple ventricular septal defects is a rare and interesting phenomenon. We describe a case of a 19-year-old male with these findings following a blunt chest trauma after a motorcycle accident.
DeFigueiredo D - - 2010
To examine the association between single umbilical artery (SUA) and cardiac defects and to determine whether patients with SUA require specialist fetal echocardiography. Incidence and type of cardiac defects were determined in fetuses with SUA detected at routine second-trimester ultrasound examination. A routine second-trimester scan was performed in 46 272 ...
Cho Yang Hyun - - 2010
A 69-year-old male patient underwent double-patch repair for a postinfarction ventricular septal defect (VSD). He returned five months later with an abscess in the area of a postoperative hematoma between the patch and the left ventricle. The abscess was drained and the ventricles were successfully reconstructed. Intracardiac hematoma after double-patch ...
Hisatomi Kazuki - - 2010
Ventricular septal perforation (VSP) is a rare but life-threatening complication of acute myocardial infarction (AMI). Even with assisted circulation heart failure often progresses quickly, and urgent surgical intervention is required to close the VSP. For several years, we have been performing a double patch closure technique using an equine pericardial ...
Turer Aslan T - - 2011
Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical features of HCM is undefined. Seventy-five consecutive adult patients with HCM were enrolled. Septal morphologies were ...
Owens Gabe E - - 2011
To determine if pulsed cavitational ultrasound therapy (histotripsy) can accurately and safely generate ventricular septal defects (VSDs) through the intact chest of a neonatal animal, with the eventual goal of developing a noninvasive technique of creating intra-cardiac communications in patients with congenital heart disease. Histotripsy is an innovative ultrasonic technique ...
Lang Nora - - 2010
Closure of muscular ventricular septal defects (mVSDs) beyond the moderator band is still a challenge for both surgeons and interventional cardiologists. We evaluated a new technique in a pig model for hybrid patch closure of mVSDs via 2 stab wound incisions in the left ventricle (LV) without cardiopulmonary bypass. Ten ...
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