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Results 601 - 650 of 681
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Contractor F M - - 1984
Acute arterial thromboembolization is a well-recognized complication following myocardial infarction. Intraarterial infusion of thrombolytic agents is a relatively new method of treating such thromboembolic occurrences. We describe a patient who was successfully treated with low-dose, intraarterial streptokinase infusion following occlusion of the right renal artery 1 week after an acute ...
Köhn H - - 1984
To evaluate a potential beneficial effect of systemic streptokinase therapy in acute myocardial infarction, 36 patients treated with streptokinase intravenously were assessed by radionuclide ventriculography and quantitative 201Tl myocardial imaging (including SPECT) in comparison with 18 conventionally treated patients. Patients after thrombolysis had significantly higher EF, PFR, and PER as ...
Kennedy J W - - 1983
Two hundred fifty patients were enrolled in a multicenter, community-based study of the efficacy of intracoronary streptokinase thrombolysis in acute myocardial infarction; 134 were randomly assigned to streptokinase therapy and 116 were controls. All patients underwent left ventricular angiography and coronary arteriography before the random assignment. The mean time from ...
Bunton R W - - 1983
Serial serum magnesium estimations, beginning before operation, were performed on 200 patients who underwent coronary artery bypass grafting. The results indicate that serum magnesium concentration is of no value in the diagnosis of myocardial infarction in the postoperative patient or in predicting which patients are susceptible to postoperative dysrhythmias. There ...
Angelini P - - 1983
The initial anatomic findings of angiography during acute myocardial infarction, as well as the techniques used for selective coronary streptokinase infusion, are presented in this report. Preliminary evaluation of streptokinase infusion studies seems to indicate that revascularization of coronary arteries occluded during myocardial infarction is quickly and easily achievable and ...
Little W C - - 1983
Thrombotic coronary artery occlusion is now recognized as the usual cause of acute myocardial infarction. The thrombus usually forms at the site of intimal disruption over an atherosclerotic plaque. Following coronary occlusion, myocardial necrosis begins within 40 minutes in the subendocardium and progresses outward toward the epicardium over the next ...
Cribier A - - 1983
Since November 1979 left ventricular angiography and coronary arteriography have been performed in 80 patients with evolving acute myocardial infarction in order to attempt coronary recanalisation by local streptokinase infusion. The average delay between the onset of symptoms and streptokinase infusion was 3.6 hours. Thrombolysis was successful in 64% of ...
Rogers W J - - 1983
To evaluate the relative thrombolytic efficacy and complications of intracoronary vs high-dose, short-term intravenous streptokinase infusion in patients with acute myocardial infarction, we performed baseline coronary arteriography and then randomly allocated 51 patients with acute myocardial infarction to receive either intracoronary (n = 25) or intravenous (n = 26) streptokinase. ...
Leary W P - - 1983
Magnesium deficiency may develop during diuretic treatment, causing serious cardiac arrhythmias hitherto ascribed to potassium depletion. Intravenous magnesium replacement therapy replenishes intracellular magnesium and potassium and inhibits cardiac arrhythmias which may occur during diuretic treatment; oral magnesium supplementation is also effective. The co-administration of amiloride with a distal-tubule diuretic prevents ...
Richardson R L RL - - 1983
Thirteen of 19 patients undergoing streptokinase infusion within five hours after acute myocardial infarction were deemed satisfactory candidates for bypass surgery. In all cases, operation was performed within less than a week, with no demonstrable ill effects from the enzyme. There was only one pulmonary-related death and only two patients ...
Gold H K - - 1983
Intracoronary streptokinase was given to 40 patients with acute transmural myocardial infarction. In 34 of the patients (85%), it resulted in reflow or improved flow. Six patients showed no reflow and six reocclusion within 2 hours. No consistent explanation was found for this resistance to therapy. Five other patients developed ...
Blanke H - - 1983
ECG changes were assessed in 15 patients in whom intracoronary streptokinase recanalized a totally occluded left anterior descending artery during acute myocardial infarction. These results were compared retrospectively with those in 22 comparable conventionally treated patients who underwent catheterization during the acute stage of infarction. Before angiography no significant differences ...
Rentrop P - - 1983
Changes of left ventricular ejection fraction (delta EF) determined by monoplane contrast angiography before intracoronary streptokinase infusion and in the chronic stage of infarction before hospital discharge were assessed in 125 patients. Preintervention EF was .49 +/- .136 and chronic EF was .025 +/- .118 higher (p = .02) in ...
Weinstein J - - 1983
The data from 224 cases of acute myocardial infarction treated with intracoronary streptokinase plus standard coronary care unit management and 178 cases of acute myocardial infarction treated solely with standard coronary care unit management were reviewed to assess the efficacy and safety of the intracoronary administration of streptokinase during evolving ...
Smalling R W - - 1983
One hundred eighty-eight patients with acute myocardial infarction were studied prospectively from August 1980 to September 1982. One hundred thirty-six of these patients were entered into a intracoronary streptokinase study after informed consent was obtained. The remaining 52 patients, who either met exclusion criteria for the study or refused to ...
Flaherty J T - - 1983
Initial studies from our institution demonstrated beneficial anti-ischemic effects of short-term infusion of intravenous nitroglycerin in patients with acute myocardial infarction. At lower doses, nitroglycerin was shown to be principally a venodilator; at higher doses, a mixed venous and arterial dilating effect was demonstrated. The acute hemodynamic effects of nitroglycerin ...
Khaja F - - 1983
We performed a randomized trial comparing intracoronary administration of streptokinase versus dextrose placebo within six hours after the onset of symptoms of acute myocardial infarction in 40 patients. The base-line clinical, hemodynamic, and angiographic findings were similar in the control and streptokinase-treated groups. Reestablishment of flow occurred in 12 of ...
Anderson J L - - 1983
Fifty patients with acute myocardial infarction were randomly assigned to receive either intracoronary streptokinase or standard (control) therapy within about three hours after the onset of pain. Coronary perfusion was reestablished in 19 of 24 patients receiving streptokinase. Streptokinase alleviated pain (as indicated by differences in subsequent morphine use). The ...
Iseri L T - - 1983
Intractable ventricular tachyarrhythmia associated with hypomagnesemia responds well to magnesium given intravenously. Two patients with recurrent ventricular tachycardia and ventricular fibrillation associated with normal serum magnesium levels and resistant to treatment with potassium chloride, lidocaine and bretylium tosylate responded dramatically to the administration of magnesium sulfate. A third patient in ...
Schröder R - - 1983
Clinically encouraging results can be obtained with an intravenous high dose short-time infusion of streptokinase in patients with evolving myocardial infarction. The feasibility and efficacy of the intracoronary and the systemic approach of streptokinase therapy in acute myocardial infarction are discussed in this report and include topics such as infarct ...
Jaffe A S - - 1983
Glyceryl trinitrate was previously said to be contraindicated in patients with acute myocardial infarction. Its intravenous administration during acute infarction, however, was associated with a beneficial effect as determined by ST segment mapping. Most recently in a selected group of patients with acute infarction and abnormal haemodynamics, intravenous glyceryl trinitrate ...
Conner C S - - 1983
Intracoronary streptokinase has been reported to be successful in producing coronary recanalization and lowered morbidity and mortality in acute myocardial infarction patients, when administered shortly after the onset of chest pain. However, intracoronary administration of streptokinase is not practical for most hospitals at present, and intravenous administration would enable treatment ...
Lijnen P - - 1983
Twenty-nine patients with recent myocardial infarction were randomly allocated to a placebo group (n = 14) and to a group (n = 15) who received sulphinpyrazone, 4 x 200 mg daily for 7 days. Renal function significantly and transiently deteriorated in the sulphinpyrazone group compared to the placebo group. In ...
Lloyd G G - - 1983
Three groups of patients were identified during a study of men who had recently suffered an acute myocardial infarction: those with psychiatric morbidity antedating the infarction and those with no significant psychopathology. Compared to the other two groups, patients with psychiatric morbidity before the infarction were more likely to be ...
Flaherty J T - - 1983
A prospective randomized clinical trial of intravenous nitroglycerin administered for 48 hours following acute infarction was undertaken to determine whether clinical improvement and/or preservation of ischemic myocardium could be demonstrated. One hundred four patients were randomized to receive either nitroglycerin or placebo infusion. Nitroglycerin infusion was titrated to lower mean ...
Feldman R L - - 1983
An intracoronary infusion of streptokinase is often administered in patients with acute myocardial infarction. To address the question of how long intracoronary streptokinase should be infused, we studied 13 patients with symptoms and electrocardiographic findings suggesting an evolving myocardial infarction. We used subselective catheterization techniques and made quantitative angiographic measurements ...
Choudhury S L - - 1983
The effects of sulphinpyrazone 800 mg daily on renal excretory function were studied in a double-blind placebo-controlled randomised trial of incremental and full doses of the drug in 28 patients with plasma urea concentration less than 10 mmol/l in the period 2-28 days following uncomplicated acute myocardial infarction. Sulphinpyrazone in ...
Schröder R - - 1983
A short review of published report shows that the recanalization rate of a completely occluded coronary artery by intravenous streptokinase (SK) infusion was of 58%, somewhat less than the 77% reported for intracoronary SK application. The thrombus lysis time lasts somewhat longer with intravenous SK infusion as compared with intracoronary ...
Walker W E - - 1982
During a 21-month period, 150 patients with acute myocardial infarction were offered entry into a study comprising emergency cardiac catheterization, streptokinase infusion for thrombus if present, and coronary artery bypass surgery where appropriate. Forty refused or were excluded, and served as a control group. Approximately 80% of the remainder had ...
Weinstein J - - 1982
Efficacy and safety data from 209 U.S. cases in the Hoechst-Roussel intracoronary streptokinase (STK) registry were analyzed. Successful recanalization was achieved in 76% of infarct-related occluded coronary arteries. Postinfarction complications (i.e., malignant arrhythmia, heart block, and pump failure) were substantially less frequent after successful recanalization compared to the recanalization failures. ...
Spann J F - - 1982
An acute thrombus at the proximal border of a high-grade atherosclerotic obstruction is the usual cause of myocardial infarction. Although intracoronary thrombolysis is potentially an exciting new therapy for reducing the extent of myocardial infarction by lysing coronary clot, a number of major difficulties limit its widespread application. It is ...
Cohn J N - - 1982
Eight hundred twelve men with presumed acute myocardial infarction and left ventricular filling pressure of at least 12 mm Hg participated in a randomized double-blind placebo-controlled trial to assess the efficacy of a 48-hour infusion of sodium nitroprusside. The mortality rates at 21 days (10.4 per cent in the placebo ...
Sammel N L - - 1982
A 48-year-old man presented to hospital with prolonged ischaemic chest pain. No electrocardiographic or enzymic changes of acute myocardial infarction were found. Angiography performed five days later showed 75% luminal narrowing of the proximal left anterior descending (LAD) coronary artery, but no other significant abnormality. On the following day, he ...
Leinbach R C - - 1982
The mechanism of left anterior descending (LAD) obstruction was studied in 30 patients with transmural anterior myocardial infarction. Nitroglycerin was given by sublingual, intravenous, and intracoronary routes, and coronary angiography was performed in less than 6 hours. The ECG ST segment elevation fell more than 50% in two patients with ...
- - 1982
In a multicentre double-blind randomised study comparing the effects of sulphinpyrazone 400 mg twice daily with those of placebo in patients after myocardial infarction 727 patients (365 on sulphinpyrazone, 362 on placebo) were enrolled and followed up for 12-48 months (mean 19.2). Treatment began 15-25 days after infarction. There were ...
Gagnon R M - - 1982
Myocardial infarction is usually caused by a thrombus occurring on a significant coronary lesion. A 60-year-old male was admitted with an acute evolving anterior myocardial infarction. Three hours after the beginning of chest pain, the electrocardiogram showed ST-segment elevation in the anterior and lateral leads which persisted despite intravenous nitroglycerin ...
Rentrop P - - 1982
A brief description of recanalization of the thrombotic coronary artery is provided, including the historical background and our own first experience of recanalization during the event of an acute catheter complication. Mechanical recanalization of occluded coronary arteries as initially performed by us is described. The subsequent use of intracoronary infusion ...
Unverferth D V - - 1981
The purpose of this study was to document early structural changes in the human heart after the initial administration of doxorubicin. Endomyocardial biopsies were performed at baseline and at 4 and 24 hours after doxorubicin administration to 13 patients. Morphometric analysis of electron micrographs (x 31,200) quantitated mitochondrial and tubular ...
Reduto L A - - 1981
Cardiac catheterization and coronary angiography were performed on hospital admission in 32 consecutive patients with acute myocardial infarction. Twenty-six patients had total occlusion of an infarct-related coronary artery and six had severe proximal stenosis with poor distal flow. In 18 of the 26 patients with total occlusion, intracoronary infusion of ...
Hockings B E - - 1981
Hemodynamic changes and mortality and morbidity were compared in a randomized controlled trial of sodium nitroprusside after acute myocardial infarction. Fifty patients with a mean pulmonary capillary wedge pressure of more than 20 mm Hg within 24 hours of acute infarction were randomly assigned to one of two groups: 25 ...
Bigg R P - - 1981
Magnesium deficiency is likely to occur in certain patients prone to developing acute myocardial infarction, such as hypertensive patients being treated with diuretics, alcoholics, diabetics and patients with ischaemic cardiomyopathy taking diuretics and digitalis. Magnesium deficiency commonly accompanies potassium deficiency, can also cause it, and can prevent correction of potassium ...
Forster A - - 1981
Serum magnesium levels fall significantly after acute myocardial infarction. Even greater decreases have been found in all patients undergoing aorto-coronary bypass surgery. This is probably related to the use of cardiopulmonary bypass. No significant difference in serum magnesium levels was found between those patients who had a well documented peri-operative ...
Hölscher B - - 1981
Rabbit hearts were subjected to cardiac arrest induced by injecting 3 isotonic cardioplegic solutions each of which contained in combination with procaine-HCl one of 3 different magnesium compounds. A period of 40 min arrest was followed by reperfusion of 15 min. A regular sinus rhythm returned after washout of the ...
Rector W G WG - - 1981
The serum levels and urinary excretion of magnesium and copper were studied in 66 patients with either acute myocardial ischemia or myocardial infarction. Serum for magnesium and copper determinations was obtained daily for three days. The initial serum magnesium levels were normal in patients with ischemia but were low in ...
Singh R B - - 1981
Magnesium ions are important for maintaining the functional and structural integrity of the myocardium. Epidemiologic studies suggest that myocardial hypomagnecytia can predispose to sudden cardiac death and that hard water protective factor preventing heart attack could be magnesium. Recent studies show that infarcted portion of the myocardium has lowered magnesium ...
Speich M - - 1980
Atomic absorption spectrometry was used to measure magnesium, calcium, and sodium, and emission spectrometry to measure potassium, in myocardium (left and right ventricles) of 26 control subjects who died of acute trauma. Results were expressed in mumol/g of proteins. Mg/Ca and K/Na ratios were also determined. The same measurements were ...
Wilcox R G - - 1980
473 patients with suspected acute myocardial infarction were entered into a randomised, double-blind, placebo-controlled comparison of disopyramide phosphate, 150 mg three times a day, and oxprenolol, 40 mg three times a day. When analysed on an intension-to-treat basis there was no significant difference in 6-week mortality between the groups, but ...
Dixon R A - - 1980
One hundred and thirty-one male patients admitted to a coronary care unit with myocardial infarction, later confirmed, were randomly allocated to receive either 10 mg diazepam every six hours, or a matched placebo, for 48 hours. During this period, no differences were found between the treatment groups in the incidence ...
- - 1979
In a controlled trial of streptokinase in acute myocardial infarction, 512 of 2338 patients at 11 European centers were stratified according to clinical severity. Three hundred fifteen patients allocated to medium-risk and high-risk groups were randomized to a 24-hour infusion of streptokinase or glucose. There were no essential differences in ...
Rentrop K P - - 1979
In five patients with acute myocardial infarction, the effects of both intracoronary nitroglycerin (NTG) and subsequent intracoronary streptokinase application were evaluated. In addition, transluminal recanalization was performed in one of these patients. Injection of NTG into the infarct-related coronary artery resulted in improved distal filling of the subtotally occluded left ...
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