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Bartoli Carlo R - - 2011
Left ventricular assist devices (LVADs) constitute a recent advance in heart failure (HF) therapeutics. As the rigorous experimental assessment of LVADs in HF requires large animal models, our objective was to develop a bovine model of cardiomyopathy. Male calves (n = 8) were used. Four animals received 1.2 mg/kg intravenous ...
Wang Jian-Xun - - 2011
Myocardial infarction is a leading cause of mortality worldwide. Here we report that modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of myocardial infarction and cardiac dysfunction induced by ischemia-reperfusion. We found that both the α- and β-isoforms of the calcineurin catalytic subunit are direct targets of miR-499 ...
Stub Dion - - 2010
Survival rates after out-of-hospital cardiac arrest (OHCA) continue to be poor. Recent evidence suggests that a more aggressive approach to postresuscitation care, in particular combining therapeutic hypothermia with early coronary intervention, can improve prognosis. We performed a single-center review of 125 patients who were resuscitated from OHCA in 2 distinct ...
Chung Sung Phil - - 2010
AIM: This study is to compare the effect of the δ-opioid receptor agonist, d-Ala(2)-d-Leu(5) enkephalin (DADLE) with normothermic control and therapeutic hypothermia on post resuscitation myocardial function and 72-h survival in a rat model of cardiac arrest and resuscitation. METHODS: Ventricular fibrillation (VF) was induced in 15 male Sprague-Dawley rats. ...
Ahmet Ismayil - - 2011
Strong cardioprotective properties of erythropoietin (EPO) reported over the last 10 years have been difficult to translate to clinical applications for ischemic cardioprotection owing to undesirable parallel activation of erythropoiesis and thrombogenesis. A pyroglutamate helix B surface peptide (pHBP), recently engineered to include only a part of the EPO molecule ...
Gorman Robert C - - 2011
The left ventricular response to a myocardial infarction is a complex biomechanical process that is only beginning to be understood. Infarct expansion (stretching) is an immediate and progressive phenomenon that is known to initiate and sustain the ventricular dilatation and global loss of contractile function that leads to symptomatic heart ...
Ye L - - 2010
The identification and analysis of several cationic ion channels and their associated genes have greatly improved our understanding of the molecular and cellular mechanisms of cardiac arrhythmia. Our objective in this study was to examine the involvement of anionic ion channels in cardiac arrhythmia. We used a transgenic (Tg) mouse ...
Liang Xiaoping - - 2011
A UPLC/TOF-MS-based metabonomic study was conducted to assess the holistic efficacy of Traditional Chinese Medicine Shuanglong Formula (SLF) for myocardial infarction in rats. Thirty male Sprague-Dawley rats were randomly divided into five groups after surgery. The Panax ginseng group, Salvia miltiorrhiza group, and SLF group were treated with water extractions ...
Wang L - - 2010
Myocardial infarction (MI) creates electrophysiologically altered substrates that are responsible for ventricular arrhythmias such as tachycardia and fibrillation. The presence, size, location, and composition of infarct scar bear significant prognostic and therapeutic implications for individual subjects. We have developed a statistical physiological-model-constrained framework that uses noninvasive body surface potential data ...
Hale Sharon L - - 2010
In many animal models, mild therapeutic hypothermia is a powerful intervention, reducing myocardial infarct size, reducing the no-reflow phenomenon, and improving healing after infarction. Cooling in these models has been produced by various means including whole-body hypothermia, synchronized hypothermic coronary venous retro-perfusion, heat exchangers, and regional hypothermia targeting the heart ...
Andrikopoulos George - - 2011
The last decade has seen dramatic advances in cardiac electrophysiology, particularly in its application for treatment of atrial fibrillation and other tachyarrhythmias. In this paper, the authors review key new technologies now beginning to impact on contemporary practice that are taking its therapeutic potential to new levels of efficacy and ...
Husainy Mohammad Ali - - 2010
BACKGROUND: Previous studies have revealed that the mitochondrial permeability transition pore (MPTP) plays a critical role in necrotic and apoptotic cell death. Given the opposed roles of the MPTP in cardioprotection (transient versus sustained opening) the primary aim of this study was to determine how two structurally different MPTP inhibitors ...
Ii Masaaki - - 2011
Human multipotent adipose-derived stem cells (hMADSCs) have recently been isolated featuring extensive expansion capacity ex vivo. We tested the hypothesis that hMADSC transplantation might contribute to cardiac functional recovery by its direct or indirect effect on myocardial infarction (MI). Nude rats were either transplanted with hMADSCs or PBS (control) in ...
Tan Alex Y - - 2010
Atrial fibrillation (AF) is the most common arrhythmia in humans. It affects 5% of the population over the age of 65 years and is projected to rise as the population ages. Experimental data from animal models of AF shows that AF is associated with progressive structural and electrical remodeling of ...
Chen Hao - - 2012
Coronary heart diseases (CHD) remain the most prevalent cause of premature death. Substantial growth of new collateral coronary vessels to the ischemic region would provide reconstitution of the occluded arteries and correction of heart ischemia. However, this remains an impossible mission with current advances. Incomplete ligation of left anterior descending ...
Huang Grace - - 2011
Recent advances in stem cell biology and tissue engineering have put forth new therapeutic paradigms for treatment of myocardial disease. The aim of stem cell therapy for myocardial regeneration has been directed to induce angiogenesis for ischemic heart disease and/or introduction of new cardiomyocytes to improve the mechanical function of ...
Talukder M A Hassan MA Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University College of Medicine, 473 West 12th Ave., Columbus, OH 43210, - - 2011
There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism and heart rate. However, conflicting results have been reported for ...
Parodi Guido - - 2010
Left ventricular (LV) remodeling has been shown to occur in a relevant proportion of patients with acute myocardial infarction successfully treated with primary percutaneous coronary intervention. The development of LV remodeling after primary percutaneous coronary intervention is associated with increased mortality and with shorter event-free survival. Therapy to prevent or ...
Takahashi Masato - - 2010
Cardiac ischemia in children is usually not an isolated disease in an otherwise normally formed coronary artery but is part of more complex congenital or acquired diseases. Although cardiac ischemia is not a frequent occurrence, it must be recognized as a serious, life-threatening event. This article lists and characterizes major ...
Chen Gordon L - - 2010
Our understanding and treatment of the ST-elevation myocardial infarction (STEMI) has led to a tremendous improvement in the care and preservation of life affecting millions yearly. As the medical community continues to discover novel strategies in therapeutics and innovations in prevention, it is imperative to understand the scientific journey the ...
Szumita Paul M - - 2010
Permanent neurologic impairment following cardiac arrest is often severely debilitating, even after successful resuscitation. Therapeutic hypothermia decreases anoxic brain injury and subsequent cognitive deficits. Current practice guidelines recommend therapeutic hypothermia in comatose survivors of cardiac arrest. To address the multifacets of therapeutic hypothermia, we assembled a multidisciplinary task force including ...
Cui Xiao-jun - - 2010
The poor survival and differentiation of the donor cells in the infarcted myocardium has hampered the therapeutic efficacy of cell transplantation. A self-assembling polypeptide RAD16-II (Ac-RARADADARARADADA-CONHâ‚‚) spontaneously assembles into stable nanofiber scaffolds, which mimic natural extracellular matrix at 0.1-1% peptide concentrations in the myocardium. We isolated mesenchymal stem cells from ...
Zhang Xuelian - - 2010
Cell-based therapy can improve cardiac function but is limited by the low cell retention and survival within ischemic tissues. Injectable cardiac tissue engineering aims to support cell-based therapies and enhance their efficacy for cardiac diseases. So far, no research has been devoted to studying the usefulness of the combination of ...
Ise Takayuki - - 2011
Thrombin has a crucial role in cardiac remodeling through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of cardiac remodeling. We investigated the relationships between plasma HCII ...
Fomovsky Gregory M - - 2011
The mechanical properties of healing myocardial infarcts are a critical determinant of pump function and the transition to heart failure. Recent reports suggest that modifying infarct mechanical properties can improve function and limit ventricular remodeling. However, little attempt has been made to identify the specific infarct material properties that would ...
He Wei - - 2010
Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of mammalian Tolloid-like 1 metalloproteinase. Bone morphogenic protein 1 (Bmp1)/Tolloid-like metalloproteinase plays a key role in the regulation of collagen biosynthesis ...
Wei Ying - - 2011
The sphingosine-1-phosphate (S1P) receptor agonist fingolimod (FTY720), that has shown efficacy in advanced multiple sclerosis clinical trials, decreases reperfusion injury in heart, liver, and kidney. We therefore tested the therapeutic effects of fingolimod in several rodent models of focal cerebral ischemia. To assess the translational significance of these findings, we ...
Le Gloan Laurianne - - 2010
PURPOSE OF REVIEW: Patients with tetralogy of Fallot are subject to arrhythmic sequelae that substantially impact morbidity and mortality. This review focuses on recent advances in our understanding of the prevalence and types of arrhythmias encountered. Diagnostic and prognostic tools are considered and therapeutic options discussed. RECENT FINDINGS: Multicenter studies ...
Adluri Ram Sudheer - - 2011
Oxidative stress plays a crucial role in disruption of neovascularization by alterations in thioredoxin 1 (Trx1) expression and its interaction with other proteins after myocardial infarction (MI). We previously showed that Trx1 has angiogenic properties, but the possible therapeutic significance of overexpressing Trx1 in chronic MI has not been elucidated. ...
Mignone John L JL Department of Pathology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, - - 2010
Over the past decade, the ability to culture and differentiate human embryonic stem cells (ESCs) has offered researchers a novel therapeutic that may, for the first time, repair regions of the damaged heart. Studies of cardiac development in lower organisms have led to identification of the transforming growth factor-β superfamily ...
Liu Yong - - 2010
Recent studies have shown that monocytes in human peripheral blood are heterogeneous. The clinical significance of 2 distinct monocyte subsets as a marker of late in-stent restenosis (ISR) following implantation of bare-metal stents (BMSs) in patients with acute myocardial infarction (AMI) was examined. Seventy-one consecutive patients with AMI who underwent ...
Ho Paul C - - 2010
Rotational atherectomy is contraindicated in the presence of coronary dissection. Clinical scenarios of coronary dissection in which rotational atherectomy offers the only option are rare but can occur. This case study presents a challenging circumstance of an extensive coronary dissection resulting from failed angioplasty of a resistant and undilatable lesion. ...
Orringer Carl E - - 2010
Cardiac computed tomography for coronary artery calcium scoring, a diagnostic test associated with relatively low radiation exposure, provides incremental coronary risk stratification above that provided by Framingham risk scoring in asymptomatic, intermediate-risk patients. Knowledge of the appropriate use of coronary calcium scoring enables the clinician to more appropriately match the ...
Ala Narayana - - 2010
Hundred years ago in Great Britain, Sir Thomas Lauder Brunton was acclaimed as an authority on the action of drugs on the heart. His famous work, "Pharmacology and Therapeutics" (1867), was read and appreciated all over Europe and America. He stated that nitrite of amyl has a beneficial effect on ...
Onuma Yosinobu - - 2010
Multimodality imaging of the first-in-man trial using a fully resorbable everolimus-eluting scaffold (BVS, Abbott Vascular, Santa Clara, CA, USA) demonstrated at two years the bioresorption of the device while preventing restenosis. Nevertheless, the long-term safety and efficacy of this novel therapy remain to be documented. The ABSORB trial completed in ...
Cortese Bernardo - - 2010
BACKGROUND: Percutaneous coronary intervention (PCI) of small vessels is limited by an increased risk of restenosis and adverse outcome, even when drug-eluting stents (DES) are employed. In recent years, the paclitaxel-coated balloon (PCB) has been shown to reduce neointimal proliferation and the need for target lesion revascularization (TLR) in an ...
Park Seung-Jung - - 2010
The efficacy of cutting or plain balloon angioplasty (CBA or PBA) has not been analyzed for the treatment of drug-eluting stent (DES) restenosis vs bare metal stent (BMS) restenosis. The 252 in-stent restenosis (ISR) lesions in 224 consecutive patients treated by CBA (n=167) or PBA (n=85) between July 2002 and ...
Hu Zuo-Ying - - 2010
Wall shear stress (SS) plays an important role in the initiation and proliferation of coronary atherosclerosis, especially for bifurcations. Stenting in the coronary artery will cause many different changes in velocity, flow, cross-sectional area, and especially the wall SS. However, it is still unknown how much wall SS distribution varies ...
Zhang Jun-Jie - - 2010
Endothelial shear stress is one of the local hemodynamic factors suspected in the development of coronary atherosclerosis in bifurcation lesions. In patients with provisional stenting, the endothelial shear stress (SS) distribution is unknown. The aim of this study was to investigate the magnitude and distribution of the SS of coronary ...
Morino Tomoki - - 2010
Recently, several studies have showed that bare metal stent (BMS) restenosis is not a benign clinical entity. However, clinical presentation of BMS restenosis in Japanese patients has not been fully evaluated. Follow-up coronary angiography after BMS implantation was performed in 473 patients with 523 lesions. Of these, BMS restenosis was ...
Chopra H K - - 2010
Echocardiography including 2 Dimensional, Color Doppler, Tissue Doppler Imaging, Myocardial Contrast Echocardiography, Strain and Strain rate, etc are the most powerful modalities for the assessment of myocardial performance in patients with established orsuspected acute coronary syndrome and acute myocardial infarction with a high accuracy, sensitivity and specificity. Dobutamine Stress Echocardiography ...
Kumar Girish - - 2010
A transient and reversible reduction in cardiac output-low cardiac output state (LCOS) often occurs following surgery for congenital heart disease. Inappropriately managed LCOS is a risk factor for increased morbidity and death. LCOS may occasionally be progressive and refractory needing a period of "myocardial rest" with extracorporeal life support (ECLS). ...
Lima-Filho M O - - 2010
The objective of this study was to identify intravascular ultrasound (IVUS), angiographic and metabolic parameters related to restenosis in patients with dysglycemia. Seventy consecutive patients (77 lesions) selected according to inclusion and exclusion criteria were evaluated by the oral glucose tolerance test and the determination of insulinemia after a successful ...
Sultana Riffat - - 2010
OBJECTIVE: To evaluate the successful revascularization in chronic total coronary occlusion lesions and to examine the relationship between lesion characteristics and procedural success and the frequency of in-hospital major adverse cardiac events after percutaneous coronary intervention in these patients. METHODS: All patients subjected to percutaneous coronary intervention from 2006 to ...
Kyono Hiroyuki - - 2010
To investigate the consequences of inflating low-pressure balloon occlusion devices in native coronary arteries. One hundred eighteen segments of 118 patients who were enrolled in the ASPARAGUS study were analysed post-procedure and at six months by means of quantitative coronary angiography. ASPARAGUS was a randomised study to assess the efficacy ...
Vaquerizo Beatriz - - 2010
Calcified coronary lesions may be associated with stent underexpansion, malapposition, and high rates of restenosis. The use of drug-eluting stents (DES) in such lesions has not been fully addressed in the major trials. We sought to examine the outcomes of patients who were treated with plaque modification (PM) to facilitate ...
Correia Emanuel - - 2010
Left-ventricular non-compaction (LVNC) is a rare congenital cardiopathy, which results from the failure of the myocardial compaction process, leading to the persistence of numerous and deep trabeculations communicating with the ventricular cavity. Its main clinical manifestations are heart failure, arrhythmias (supraventricular or ventricular) and episodes of arterial embolism. The present ...
Kim Hee-Yeol - - 2010
Treatment of coronary chronic total occlusions (CTOs) remains a challenging obstacle, posing a considerable barrier to achieving successful complete revascularization. By nature of their complexity, percutaneous CTO interventions are associated with lower rates of procedural success, higher complication rates, greater radiation exposure and longer procedure times compared with non-CTO interventions. ...
Kim Jeong Su - - 2010
We investigated the impact of metabolic syndrome (MS) on the occurrence of in-stent restenosis (ISR) and long-term major adverse cardiac events (MACEs), including cardiovascular death, myocardial infarction, and target vessel revascularization (TVR) during a follow-up period of 36 months after percutaneous coronary intervention (PCI) with stent implantation in patients with ...
Yang Gui-Tang - - 2010
BACKGROUND: The patients with unprotected left main coronary artery (ULMCA) stenosis and chronic total occlusion (CTO) lesions at the left anterior descending (LAD) artery are often recommended for bypass surgery. However, some of these patients are deemed inoperable or are at high risk for surgery. In this study, we explored ...
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