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Sabaté Manel M University Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, - - 2013
This study sought to study the efficacy and safety of newer-generation drug-eluting stents (DESs) compared with bare-metal stents (BMSs) in an appropriately powered population of patients with ST-segment elevation myocardial infarction (STEMI). Among patients with STEMI, early generation DESs improved efficacy but not safety compared with BMSs. Newer-generation DESs, everolimus-eluting ...
Buchanan Gill Louise - - 2013
Aims: To assess two-year outcomes following first vs. new-generation drug-eluting stent (DES) implantation in unprotected left main (ULMCA) percutaneous coronary intervention. Methods and results: All eligible patients from our two-centre registry treated with first and new-generation DES from October 2006 to November 2010 were analysed. The study objective was major ...
Choi Ik Jun IJ Cardiovascular Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, - - 2013
Stent length has been considered an important predictor of adverse events after percutaneous coronary intervention, even with the first-generation drug-eluting stents (DESs). The introduction of newer-generation DES has further reduced the rates of adverse clinical events such as restenosis, myocardial infarction, and stent thrombosis. The aim of this study was ...
Garg Ankit - - 2013
Objectives: The objective of this study is to compare the long term safety of new generation drug-eluting stents (DES) with early generation DES and bare metal stents (BMS) for ST-elevation myocardial infarction (STEMI). Background: Early generation DES for STEMI have reduced target vessel revascularization, but have more very late stent ...
Velthuis Bob Oude - - 2013
Although atrial fibrillation (AF) is the most commonly encountered arrhythmia, some of the properties make its detection challenging. In daily practice, underdiagnosis can lead to less effective treatment in prevention of stroke. Based on data from studies on treatment of AF, more intensive follow-up strategies, including 7-day Holter recording, 30-day ...
Barold S Serge - - 2013
Electrocardiographic artifacts may generate recordings mimicking supraventricular and ventricular tachyarrhythmias. This report describes the diagnostic challenge presented by Holter or loop recordings in two patients, one with pseudo-atrial flutter and the other with pseudo- -polymorphic ventricular tachycardia.
Wang Lishan - - 2013
Drug-eluting stents (DES) are increasingly used for treatment of acute coronary syndrome (ACS). However, clinical efficacy and safety of various types of DES is not well established in these subjects. We therefore evaluated clinical utility of second-generation and first-generation DES in patients with ACS by conducting a meta-analysis. A search ...
Barry Sarah J E - - 2013
Routinely collected electronic patient records are already widely used in epidemiological research. In this work we investigated the potential for using them to identify endpoints in clinical trials. The events recorded in the West of Scotland Coronary Prevention Study (WOSCOPS), a large clinical trial of pravastatin in middle-aged hypercholesterolaemic men ...
Kottke Thomas E TE HealthPartners Institute for Education and Research, Minneapolis, MN 55440-1524, USA. - - 2013
The advent of universal health care coverage in the United States and the use of electronic health records can make the medical record a disease surveillance tool. The objective of our study was to identify criteria that accurately categorize acute coronary and heart failure events by using electronic health record ...
Dale Brian - - 2012
Compared with warfarin, dabigatran is associated with less intracranial hemorrhage, but an increased risk of myocardial infarction. To explore these phenomena, we compared their effects on thrombin generation. Thrombin generation in plasma from 10 patients taking therapeutic doses of warfarin (mean INR 2.6) was compared with that in plasma containing ...
Corti R - - 2012
The introduction of bare metal stents in the early 1990 and of 1st generation drug eluting stents (DES) in the early 2000 defined a new era in interventional cardiology. DES dramatically reduced instent restenosis and the need of revascularization after percutaneous coronary intervention. However, this increased efficacy came at the ...
Cottage Christopher T - - 2012
Cardiac regeneration following myocardial infarction rests with the potential of c-kit+ cardiac progenitor cells (CPCs) to repopulate damaged myocardium. The ability of CPCs to reconstitute the heart is restricted by patient age and disease progression. Increasing CPC proliferation, telomere length, and survival will improve the ability of autologous CPCs to ...
Hu Norman - - 2012
To understand the structure-function relationship in the postinfarcted myocardium in rabbits, we induced cardiac ischemia by ligating the left circumflex coronary artery. Sham controls underwent thoracotomy only. At 7 and 30 d after ligation, cardiac MRI was conducted by using pulse-oxymetry-gated cine acquisition to provide complete phases of the heartbeat. ...
Weischer Maren - - 2011
OBJECTIVE: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. METHODS AND RESULTS: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the ...
Shudo Yasuhiro - - 2011
OBJECTIVE: To evaluate serial data on left ventricular and myocardial reverse remodeling after restrictive mitral annuloplasty. METHODS: Thirteen patients (age, 64 ± 6 years) with functional mitral regurgitation associated with dilated cardiomyopathy (ejection fraction, ≤35%) were examined before (baseline), soon (1.7 ± 1.5 months), and more than 1 year (16 ...
Takayama Hiroo - - 2011
Left ventricular assist device therapy as a destination therapy for end-stage heart failure has made a large leap with continuous flow devices. Continuous flow does not seem to have a detrimental effect on end-organ function, at least in the midterm. Various expected and unexpected complications have been reported associated with ...
Reed Shelby D - - 2011
The selection of economic end points in acute decompensated heart failure (ADHF) clinical trials requires prospectively planned evaluations that are developed in tandem with clinical end points. Integrating economic end points with concrete clinical outcomes postdischarge will provide meaningful data to evaluate a treatment's incremental value in the setting of ...
Güzeltaş Alper - - 2011
OBJECTIVE: To assess the reference values of M-mode echocardiographic measurements in healthy newborns according to body weight. METHODS: From January, 2008 to June, 2008, a total of 250 - 130 female and 120 male - term healthy newborns were included in the study. M-mode echocardiographic measurements were recorded by a ...
Shudo Yasuhiro - - 2011
Background- We assessed changes in left ventricular (LV) volume and function and in regional myocardial wall stress in noninfarcted segments after restrictive mitral annuloplasty (RMA) with or without surgical ventricular restoration (SVR). Methods and Results- Thirty-nine patients with ischemic cardiomyopathy (ejection fraction ≤0.35) and severe mitral regurgitation (≥3) were studied ...
Alter Peter - - 2011
AIMS: Occurrence of late gadolinium enhancement (LGE) as assessed by cardiac magnetic resonance (CMR) imaging has been attributed to various myocardial injuries. We hypothesized that LGE is associated with left ventricular (LV) wall stress. METHODS AND RESULTS: We examined 300 patients with suspected non-ischaemic dilated cardiomyopathy. Cardiac magnetic resonance was ...
Scott Paul A - - 2011
Background:  Cardiac resynchronization therapy (CRT) may be proarrhythmic in some patients. This may be due to the effect of left ventricular (LV) epicardial pacing on ventricular repolarization. The purpose of this study was to evaluate the effect of endocardial versus epicardial LV biventricular pacing on surface electrocardiogram (ECG) parameters that ...
Broukhim Michael - - 2011
Medical management of patients with atrial fibrillation (AF) at high risk for stroke is limited by problems of imperfect tools for assessment of thromboembolism and bleeding risks. Improved instruments, such as the CHA₂DS₂VASc and HAS-BLED risk stratification scores, have been incorporated into European practice guidelines. Until recently, the most effective ...
Bentzen Bo Hjorth - - 2011
Transgenic rabbits expressing pore mutants of K(V)7.1 display a long QT syndrome 1 (LQT1) phenotype. Recently, NS1643 has been described to increase I(Kr).We hypothesized that NS1643 would shorten the action potential duration (APD(90)) in LQT1 rabbits. Transgenic LQT1 rabbits were compared with littermate control (LMC) rabbits. In vivo electrocardiogram studies ...
Purushothaman Sreeja - - 2011
Left ventricular hypertrophy is an adaptive response to hypertension, and an independent clinical risk factor for cardiac failure, sudden death, and myocardial infarction. As regression of cardiac hypertrophy is associated with a lower likelihood of cardiovascular events, it is recognized as a target of antihypertensive therapy. This necessitates identification of ...
Kolettis Theofilos M - - 2011
Myocardial tissue engineering involves the design of biomaterial scaffolds, aiming at regenerating necrotic myocardium after myocardial infarction. Biomaterials provide mechanical support to the infarct area and they can be used as vehicles for sustained and controlled local administration of cells and growth factors. Although promising results have been reported in ...
Bruce Charles J - - 2011
Chronic Percutaneous Epicardial Appendage Closure. Objectives: To assess the chronic safety and feasibility of percutaneous epicardial closure of the left atrial appendage (LAA) guided by electrical navigation. Background: Atrial fibrillation (AF) is associated with stroke, and LAA occlusion may be a useful nonpharmacologic strategy for stroke prevention in AF. Methods: ...
Lu Zhibing - - 2011
Atrial Restitution Properties. Introduction: The restitution hypothesis suggests that action potential duration (APD) restitution slope >1 predicts the development of alternans and fibrillation. This study aimed to investigate the effects of autonomic interventions on the restitution properties on the atria. Methods and Results: In 10 anesthetized open-chest dogs, multiple electrode catheters ...
Mandache E - - 2010
The human heart can be frequently affected by an organ-limited amyloidosis called isolated atrial amyloidosis (IAA). IAA is a frequent histopathological finding in patients with long-standing atrial fibrillation (AF). The aim of this paper was to investigate the ultrastructure of cardiomyocytes and telocytes in patients with AF and IAA. Human ...
Sueda Taijiro - - 2010
We postulated that chronic atrial fibrillation (AF) associated with mitral valve disease originated from the distended left atrium and is maintained by itself. We had performed a simple left atrial procedure for the elimination of chronic AF associated with mitral valve disease in patients from 1993 to 1998. This paper ...
Lu Zhibing - - 2010
the mechanism underlying spontaneous rapid superior vena cava (SVC) firing that initiates atrial fibrillation (AF) remains poorly understood. We investigated the role of the SVC-aorta-ganglionated plexus (SVC-Ao-GP) in AF initiated by rapid firing from the SVC. in 42 dogs, a circular catheter was positioned above the SVC-atrial junction. Multielectrode catheters ...
Climent Andreu M - - 2010
During atrial fibrillation (AF), RR interval histograms show different populations of predominant RR (pRR) intervals. These pRR intervals have been suggested to be multiples of the refractory period of the atrioventricular (AV) node or caused by the existence of a dual AV node physiology. In this study, the hypothesis that ...
Oh Seil - - 2010
Catheter ablation targeting of complex fractionated atrial electrograms (CFAEs) is one of the techniques used for atrial fibrillation (AF) ablation. The ablation of sites showing a high-frequency spectral component (HFC) during sinus rhythm, known as AF nests, has been introduced as an adjunct to conventional ablation. Known locations of some ...
Tsao Hsuan-Ming - - 2011
Understanding pulmonary vein (PV) function before and after catheter ablation can validate the benefit of the treatment and provide mechanistic insight into atrial fibrillation (AF). This study was aimed to investigate the functional remodeling process of PVs by multi-detector computed tomography (MDCT). We assessed the dynamic function of four PVs ...
Nishida Kunihiro - - 2010
the aim of this study was to establish the electrophysiological consequences of pulmonary vein encircling ablation (PVEA) and linear left atrial roof ablation (LARA) for the atrial fibrillation (AF) substrate in an experimental model. sequential application of ablation lesions is often used in the management of AF, almost always incorporating ...
Scherlag Benjamin J - - 2011
In this review, we initially covered the basic and clinical reports that provided the prevalent concepts underlying the mechanisms for atrial fibrillation (AF). The clinical evolution of catheter ablation and its eventual application to AF has also been detailed. A critique of the results based on a review of the ...
Ravelli Flavia - - 2011
Stretch Slows Conduction in the Human Atrium. Introduction: The mechanisms by which atrial stretch favors the development of a substrate for atrial fibrillation (AF) are not fully understood. In this study, the role of stretch-induced conduction changes in the creation of a proarrhythmic substrate has been investigated by quantifying the spatial ...
- - 2010
Atrial fibrillation (AF) is the commonest sustained heart arrhythmia and is associated with significant morbidity and mortality, with, for example, one in five of all strokes being attributable to the condition. Dronedarone (pronounced dro-ne-da-roan) (Multaq--sanofi-aventis) is a new anti-arrhythmic drug related to the established anti-arrhythmic amiodarone. It is licensed for ...
Chou Shing-Hsien - - 2010
In atrial fibrillation (AF), left ventricular (LV) systolic function positively correlates with the ratio of the preceding to prepreceding RR intervals (RRp/RRpp) and single-beat determination of LV function at a beat with equal RRp and RRpp closely estimates the average value over all cardiac cycles. The study was designed to ...
Lu Zhibing - - 2011
The atrial potential duration (APD) restitution has been suggested to play an important role in ventricular fibrillation; however, its role in atrial fibrillation (AF) has not been determined. This study sought to investigate the APD restitution properties in two different AF models: vagally mediated AF and 6-h rapid atrial pacing-induced ...
Lee Young-Soo - - 2010
Radiofrequency catheter ablation of the cavotricuspid isthmus (CTI) is effective in the treatment of typical atrial flutter (AFL) and atrial fibrillation (AF). AF and AFL often coexist. However, AF often occurs following successful ablation of CTI. The aim of this study was to investigate the predictors of concomitant AF following ...
Wilton Stephen B - - 2010
Catheter ablation is a promising therapy for atrial fibrillation (AF), but its utility in patients with left ventricular systolic dysfunction (LVSD) is uncertain. The objectives of this study were to perform a systematic review and meta-analysis of randomized and observational studies comparing the rates of recurrent AF, atrial tachycardia (AT), ...
Eckstein Jens - - 2011
This study aims to determine the degree and mechanisms of endo-epicardial dissociation of electrical activity during atrial fibrillation (AF) and endo-epicardial differences in atrial electrophysiology at different stages of atrial remodelling. Simultaneous high-density endo-epicardial mapping of AF was performed on left atrial free walls of goats with acute AF, after ...
Masson Serge - - 2010
Inflammation may play a significant role in the pathogenesis of atrial fibrillation (AF). To examine the roles of three systemic inflammatory markers in predicting recurrent AF. The association between the plasma concentrations of high-sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6) and pentraxin-3 (PTX3) with echocardiographic parameters and with the time ...
Fink Agnes - - 2011
We report on a patient with ischaemic cardiomyopathy who had received an implantable cardioverter-defibrillator for recurrent ventricular tachycardia (VT). He also developed paroxysmal atrial fibrillation (AF) which led to therapy with dronedarone. As demonstrated by the device memory, the drug not only suppressed AF but also completely suppressed VT.
Nishida Kunihiro - - 2011
Pulmonary vein (PV)-encircling ablation, which is effective in suppressing atrial fibrillation (AF), damages autonomic ganglia near the PV ostia. This study examined the effects of PV isolation (PVI) vs. peri-PV ganglionic plexus ablation (GPA) in two discrete canine AF models: ventricular tachypacing (240 bpm, 2 weeks)-induced congestive heart failure (CHF), ...
Suenari Kazuyoshi - - 2011
The relationship between pulmonary veins (PVs) with atrial fibrillation (AF) initiating triggers and their surrounding atrial substrate has not been elucidated. We aimed to clarify the atrial substrate properties around the PVs. Twenty-three paroxysmal AF patients were studied with the identification of PV initiating triggers. High-density mapping of the dominant ...
Ambrosi Christina M - - 2011
Defibrillation therapy for atrial fibrillation (AF) and flutter (AFl) is limited by pain induced by high-energy shocks. Thus, lowering the defibrillation energy for AFl/AF is desirable. In this study we applied low-voltage multiple-shock defibrillation therapy in a rabbit model of atrial tachyarrhythmias comparing its efficacy to single shocks and antitachycardia ...
Oliveira Mário - - 2011
Vagal activity is thought to influence atrial electrophysiological properties and play a role in the initiation and maintenance of atrial fibrillation (AF). We evaluated the effects of acute vagal stimulation on atrial conduction, refractoriness of atrial and pulmonary veins (PVs) and inducibility of AF. An open-chest epicardial approach was performed ...
Verheule Sander - - 2010
Over a time course of months, the stability of atrial fibrillation (AF) gradually increases and the efficacy of pharmacological cardioversion declines both in humans and in animal models. Changes in fibrillatory conduction over this period largely are unexplored. Goats were instrumented with an atrial endocardial pacemaker lead and a burst ...
de Groot Natasja M S - - 2010
BACKGROUND: During persistent atrial fibrillation (AF), waves with a focal spread of activation are frequently observed. The origin of these waves and their relevance for the persistence of AF are unknown. METHODS AND RESULTS: In 24 patients with longstanding persistent AF and structural heart disease, high-density mapping of the right ...
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