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Kirchhof Paulus - - 2009
Atrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far, we do not have the means to prevent AF or AF-related complications adequately. Therefore, over 70 experts on atrial fibrillation convened for the 2nd AFNET/EHRA consensus conference to suggest directions for research to improve management of AF ...
Takahashi Naohiko - - 2009
Atrial fibrillation (AF) is the commonest arrhythmia. Studies have shown that atrial tachypacing (artificial persistent AF) causes electrical remodelling. This is characterised by the shortening of the atrial effective refractory period (ERP), in which reduction in L-type Ca(2+) channel current plays an essential part. Atrial fibrosis, a feature of structural ...
Toutouzas Konstantinos - - 2009
Atrial fibrillation (AF) is the most common sustained rhythm disturbance resulting in substantial morbidity and mortality as well as increased medical costs in general population. The possible association between AF and inflammation is suggested by several studies that are based on the identification of inflammatory serum biomarkers that are elevated ...
De Vos Cees B - - 2009
INTRODUCTION: The atrial fibrillation cycle length (AFCL) and the intracardiac atrial electrogram morphology may be used to characterize atrial fibrillation (AF). However, assessment of these parameters requires an invasive electrophysiological study. We assessed clinical and electrophysiological correlates of noninvasive tissue velocity imaging (TVI) of the right and left atrial myocardial ...
Solinas Marco - - 2010
Minimally invasive mitral valve surgery is becoming increasingly popular worldwide. Mitral valve disease is often associated with atrial fibrillation (AF), also due to the ageing of the population. We present a technique to perform a left atrial ablation with bipolar irrigated radio-frequency (RF) through a single right thoracotomy. We have ...
Tozzi Piergiorgio - - 2010
Half of the patients with end-stage heart failure suffer from persistent atrial fibrillation (AF). Atrial kick (AK) accounts for 10-15% of the ejection fraction. A device restoring AK should significantly improve cardiac output (CO) and possibly delay ventricular assist device (VAD) implantation. This study has been designed to assess the ...
Chan Chin Pang - - 2010
BACKGROUND: Left atrial appendage (LAA) isolation is rare and may be associated with impaired transport function and thromboembolism. OBJECTIVE: The purpose of this study was to determine the mechanisms of inadvertent isolation of the LAA during atrial fibrillation (AF) ablation. METHODS: This study consisted of 11 patients (ejection fraction 0.43 ...
Lo Li-Wei - - 2009
The development of catheter ablation for paroxysmal atrial fibrillation (AF) has evolved rapidly over the last 10 years from an experimental unproven procedure to a commonly performed ablation therapy in many major hospitals. The pulmonary vein (PV) and left atrium were discovered to be critical in the initiation and perpetuation ...
Alessandri N - - 2009
BACKGROUND: Some of theories try to explain the insurgence of atrial fibrillation (AF) in patients with acute articular rheumatism (AAR). These theories remind the close relation between AF and left atrium, or with valvular vitium degree, or monophasic action potential and histological cardiac structure. In 15 years of work in ...
Redfearn Damian P - - 2009
AIMS: Ablation of complex fractionated atrial electrograms (CFAEs) during atrial fibrillation (AF) has been used as adjunct to contemporary techniques or as an alternative. Temporo-spatial stability of CFAE has been demonstrated in single episodes of AF. We examined temporo-spatial reproducibility of CFAE in two distinct episodes of AF. METHODS AND ...
Conde-Agudelo Agustín - - 2009
We conducted an evidence-based review of information about [corrected] amniotic fluid embolism (AFE). The estimated incidence of AFE is 1:15,200 and 1:53,800 deliveries in North America and Europe, respectively. The case fatality rate and perinatal mortality associated with AFE are 13-30% and 9-44%, respectively. Risk factors associated with an [corrected] ...
Toh Norihisa - - 2010
Atrial fibrillation (AF) often occurs in Brugada syndrome (BrS), and BrS patients with spontaneous AF often experience ventricular fibrillation (VF) attacks. Atrial vulnerability providing a substrate for AF is known to be enhanced in BrS, but there are no data on atrial structural attributes. The objective of this study was ...
Burstein Brett - - 2009
RATIONALE: Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), connexin alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention. OBJECTIVE: To analyze connexin changes and their potential contribution to the atrial fibrillation (AF) substrate during the development and reversal of CHF. METHODS ...
Nof Eyal - - 2010
Short QT (SQT) syndrome (SQT) 1 is an inherited sudden death syndrome often associated with atrial fibrillation (AF). We examined the cellular basis for AF in a newly developed experimental atrial model of SQT1. Action potentials (APs) were recorded from the pectinate muscle (PM) and crista terminalis (CT) regions of ...
Marcus Gregory M GM Division of Cardiology, University of California, San Francisco, CA, USA. - - 2010
A decrease in inflammation after cure of atrial arrhythmias suggests that such arrhythmias are proinflammatory, and lower inflammatory marker levels in the coronary sinus suggest that atrial arrhythmias result in intracardiac appropriation of inflammatory cytokines. The purpose of this study was to investigate the effect of atrial fibrillation on inflammatory ...
Matsumoto Naomichi - - 2010
BACKGROUND: Vanoxerine produces potent block of cardiac hERG, sodium, and L-type calcium channels. Block is strongly frequency dependent, is unassociated with transmural dispersion of repolarization, and occurs at concentrations safe in humans. Therefore, we proposed that vanoxerine might be antiarrhythmic. In these studies, we tested the hypothesis that vanoxerine would ...
Mischke Karl - - 2010
INTRODUCTION: The right inferior ganglionated plexus (RIGP) selectively innervates the atrioventricular node. Temporary electrical stimulation of this plexus reduces the ventricular rate during atrial fibrillation (AF). We sought to assess the feasibility of chronic parasympathetic stimulation for ventricular rate control during AF with a nonthoracotomy intracardiac neurostimulation approach. METHODS AND ...
Spitzer Stefan G - - 2009
INTRODUCTION: PASTA (pacing of the atria in sinus node disease) is a prospective and randomized trial, assessing the effect of different atrial lead positions on the atrial fibrillation (AF) incidence in patients with sinus node disease (SND). METHOD: The atrial lead position is randomized to: (a) free right atrial wall, ...
Lip Gregory Y H - - 2010
There remains uncertainty over optimal antithrombotic management strategy for patients with atrial fibrillation (AF) presenting with an acute coronary syndrome and/or undergoing percutaneous coronary intervention/stenting. Clinicians need to balance the risk of stroke and thromboembolism against the risk of recurrent cardiac ischaemia and/or stent thrombosis, and the risk of bleeding. ...
Mathew Sunil T - - 2009
Atrial fibrillation (AF) remains the most common clinically encountered arrhythmia. Unlike supraventricular arrhythmias that use a defined mechanism, AF involves a wide spectrum of arrhythmias from lone AF to paroxysmal to chronic AF. AF is an arrhythmia that may develop in several ways. Mechanical remodeling manifests as decreased atrial contractility ...
Lau Dennis H - - 2009
Atrial fibrillation (AF) has been established as an independent predictor of long-term mortality after acute myocardial infarction. However, this is less well defined across the whole spectrum of acute coronary syndromes (ACSs). The Acute Coronary Syndrome Prospective Audit is a prospective multicenter registry with 12-month outcome data for 3,393 patients ...
Priester Rory - - 2009
External or internal shocks administered to terminate ventricular arrhythmias as a part of electrophysiology or implantable cardioverter-defibrillator testing, can inadvertently cardiovert atrial fibrillation (AF). Moreover, anticoagulation therapy is often withheld in these patients in anticipation of an invasive procedure. The risk of embolic events during these procedures has not been ...
Hanke Thorsten - - 2009
BACKGROUND: Twenty-four-hour Holter monitoring (24HM) is commonly used to assess cardiac rhythm after surgical therapy of atrial fibrillation (AF). However, this "snapshot" documentation leaves a considerable diagnostic window and only stores short-time cardiac rhythm episodes. To improve accuracy of rhythm surveillance after surgical ablation therapy and to compare continuous heart ...
Pellman Jason - - 2010
Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias, including congestive heart failure (CHF) and atrial fibrillation (AF). Inducibility of AF as a result of atrial fibrosis has been the subject of intense recent investigation since it is the most commonly encountered arrhythmia in adults and can ...
Krummen David E - - 2009
Animal studies show that atrial fibrillation (AF) may emanate from sites of high rate and regularity, with fibrillatory conduction to adjacent areas. We used simultaneous mapping to find evidence for potential drivers in human AF defined as sites with higher rate and regularity than surrounding tissue. In 24 patients (age ...
Fatema Kaniz - - 2009
Atrial fibrillation (AF) is a multivariable disease. Young patients with paroxysmal AF without structural cardiac abnormality ("lone AF") likely have a primary electropathy with excellent results from radiofrequency ablation. However, with persistent AF with cardiac abnormalities, including left atrial enlargement and systolic ventricular dysfunction (ejection fraction percent), the electropathy is ...
Garcia Danielle - - 2009
In the armamentarium for rhythm control, amiodarone has been a mainstay of therapy for the management of atrial fibrillation (AF). Although amiodarone has shown to be effective in maintaining sinus rhythm, it has many extracardiac adverse effects. Dronedarone, a benzofuran amiodarone derivative, is structurally modified to reduce toxicities often associated ...
Kubota Tomoki - - 2009
OBJECTIVES: The purpose of this study was to elucidate the usefulness of integrated backscatter (IBS) transesophageal echocardiography (TEE) for the evaluation of atrial degeneration and clarify whether atrial degeneration predicts the occurrence of atrial fibrillation (AF). BACKGROUND: One of the causes of AF is pathological degeneration of the left atrium ...
Kang Hyunjae - - 2009
The purpose of this study was to investigate the relationship between chronic atrial fibrillation (AF) and reduced pulmonary function. Eighty-six chronic AF patients who were enrolled from annual health examination programs were studied using echocardiography and pulmonary function tests (PFT). Echocardiography and PFT matched for age, gender, and year performed ...
Sakamoto Tamotsu - - 2009
BACKGROUND: This study evaluated antiarrhythmic effects of d,l-sotalol in a canine atrial fibrillation (AF) model with left ventricular dysfunction. METHODS AND RESULTS: Thirteen beagles (Sotalol group n=7 and Control group n=6) were subjected to atrial tachypacing (ATP) (400 beats/min) with intact atrioventricular conduction for 4 weeks. Oral d,l-sotalol (2 mg/kg) ...
Yalta Kenan - - 2010
Natriuretic peptides (NPs) have been regarded as of diagnostic and prognostic importance in a variety of clinical conditions including congestive heart failure (CHF). Paroxysmal and persistent atrial fibrillations (AFs) have been reported to be associated with high plasma levels of NPs that decline after restoration of sinus rhythm. Rhythm control ...
Ab??cherli Roger - - 2009
BACKGROUND: Atrial fibrillation (AF) develops as a consequence of an underlying heart disease such as fibrosis, inflammation, hyperthyroidism, elevated intra-atrial pressures, and/or atrial dilatation. The arrhythmia is initiated by, or depends on, ectopic focal activity. Autonomic dysfunction may also play a role. However, in most patients, the actual cause of ...
Asada-Kamiguchi Junko - - 2009
To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF). Ten healthy adult dogs were studied to correlate V(p) with the invasive minimum value of the first derivative of LV pressure decay ...
Winkel T A - - 2009
BACKGROUND: Chronic atrial fibrillation (AF) in a non-surgical setting is associated with cardiovascular events. However, the prognosis of transient new-onset AF during vascular surgery is unknown. OBJECTIVE: The purpose of this study is to investigate the prognosis of new-onset AF during vascular surgery using continuous electrocardiographic monitoring (continuous-ECG). METHODS: In ...
Schrickel Jan Wilko - - 2009
PURPOSE: Gelsolin (gsn) is involved in the reorganization of the cytoskeleton, thereby modulating cardiomyocytal L-type Ca(2+) channels. We investigated global cardiac electrophysiological characteristics in a gsn-deficient (gsn(-/-)) mouse strain. METHODS: Using transvenous catheterization, atrial and ventricular stimulation were performed in 15 male mice [eight gsn(-/-), seven wild-type (gsn(+/+))]. Surface ECG, ...
Asanin Milika R - - 2009
BACKGROUND: The long-term risk of stroke after acute myocardial infarction (AMI) complicated with new-onset atrial fibrillation (AF) remains unclear. The aim of this study was to determine the long-term risk of AF and stroke in patients with AMI complicated with new-onset AF. METHODS: Patients with AMI complicated with new-onset AF ...
Caldwell Jane C - - 2009
AIMS: Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic heart failure (CHF). Under-detection of asymptomatic paroxysmal AF (PAF) underestimates the true burden of AF in patients with CHF. We retrospectively studied the prevalence of asymptomatic PAF in 162 CHF patients through analysis of cardiac resynchronization ...
Marrouche Nassir F - - 2009
Electrical isolation of the pulmonary veins by catheter ablation is an emerging treatment modality for the treatment of atrial fibrillation (AF) and is increasingly used in patients with heart failure. The catheter ablation versus standard conventional treatment in patients with left ventricular dysfunction and atrial fibrillation trial (CASTLE-AF) is a ...
Silberbauer John - - 2009
PURPOSE: The purpose of this study is to identify the electrophysiological factors affecting symptoms in paroxysmal atrial fibrillation (PAF) using patients with paroxysmal atrial fibrillation and pacemakers with advanced atrial fibrillation (AF) diagnostics. METHODS: Seventy-nine patients (age 71.0 +/- 8.2, 54.4% male) with symptomatic PAF and AF burden of 1% ...
Chard Marisa - - 2009
Atrial fibrillation (AF) is the most common cardiac arrhythmia, with increased incidence among the elderly population. The concept that ectopic activity in pulmonary veins (PVs) could be responsible for triggering AF has been put forward, and the inter-relationship between PVs and left atrium has been the subject of many anatomical ...
Wang Mei - - 2009
INTRODUCTION: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. METHODS: We performed ...
Zareba Karolina M - - 2009
There are limited data comparing admission electrocardiograms (ECGs) in patients with acute diastolic (DHF) vs systolic heart failure (SHF) and their ability to predict cardiac events (CEs). Admission ECGs were evaluated in 241 acute heart failure patients (88 DHF; 153 SHF). DHF was defined as left ventricular ejection fraction >45%. ...
Mamas Mamas A - - 2009
Atrial fibrillation (AF) is one of the commonest sustained arrhythmias in chronic heart failure (CHF), although the prognostic implications of the presence of AF in CHF remain controversial. We have therefore performed this meta-analysis to study the effects of the presence of AF on mortality in CHF patients. A systematic ...
Patel Dimpi - - 2009
Atrial fibrillation (AF) and congestive heart failure (CHF) are cardiovascular epidemics. Catheter ablation of AF is increasingly performed in patients with CHF. Atrioventricular junction ablation (AVJA) and pulmonary vein isolation are the two predominant ablation strategies used to treat AF patients who are refractory to drugs. In patients with CHF ...
Hwang Hye Jin - - 2011
Inflammation is frequently associated with the development of atrial fibrillation (AF). This study was performed to investigate whether the high sensitivity C-reactive protein (hsCRP) present during acute inflammation could predict early AF and its relationship to left atrial (LA) enlargement in acute myocardial infarction (AMI). In 401 consecutive AMI patients, ...
Petrutiu Simona - - 2009
BACKGROUND: In most patients, atrial fibrillation (AF) is initiated and maintained by pulmonary vein foci, but the relationship between left atrial (LA) events and the surface electrocardiogram (ECG) is largely unknown. We investigated whether LA events are reflected in the surface ECG and whether additional information can be obtained from ...
Gemein Christopher - - 2009
AIMS: Ventricular rate control is considered as an initial choice of therapy in many patients with atrial fibrillation (AF). We could previously show that electrostimulation of the right inferior ganglionated plexus (RIGP), which supplies the AV node, instantly decreases ventricular rate during AF. This study describes the development of a ...
Bortone Agustín - - 2009
AIMS: In the setting of congestive heart failure (CHF), atrial fibrillation (AF) ablation can improve clinical status and the left ventricular ejection fraction (LVEF) value. However, the impact of AF ablation on the implantable cardioverter defibrillator (ICD) indication has never been specifically addressed. METHODS AND RESULTS: Study subject were six ...
Dash S - - 2009
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Timely diagnosis of the arrhythmia, particularly transient episodes, can be difficult since patients may be asymptomatic. In this study, we describe a robust algorithm for automatic detection of AF based on the randomness, ...
Lu Zhibing - - 2009
Previous studies showed that autonomic activation by high-frequency electrical stimulation (HFS) during myocardial refractoriness evokes rapid firing from pulmonary vein (PV) and atria, both in vitro and in vivo. This study sought to investigate the autonomic mechanism underlying the rapid firings at various sites by systematic ablation of multiple ganglionated ...
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