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Ayliffe W - - 1992
To determine whether a preoperative blood transfusion could influence corneal graft rejection, full-thickness 3 mm orthotopic corneal grafts were performed in Dark Agouti (DA) rats from syngeneic (DA) or allogeneic (Brown Norway and Lewis) inbred donors and in Lewis rats from syngeneic (Lewis) or allogeneic (DA) donors. Rats with syngeneic ...
Mennander A - - 1992
Non-immunosuppressed rat aortic allografts from DA (RT1av1) to WF (RT1u) strain develop, after a short reversible acute rejection episode, chronic arteriosclerotic changes in the vascular wall, which are indistinguishable from those seen in human allografts during chronic rejection. Incubation of the aortic wall segments in vitro and immunochemical assays demonstrated ...
Jiang H H Department of Urology, Osaka University Medical School, Osaka, - - 1992
ACI heart grafts are rejected, at an accelerated pace, in Lewis (LEW) rats sensitized by donor-type blood admixed with immunoadjuvant (adjuvant complete Freund, ACF) 7 days earlier. In an in vitro study, the anti-ACI cytotoxic antibody titers in the serum increased from 1:4 in nonsensitized rats to 1:128 in sensitized ...
Jiang H - - 1992
Survival of ACI rat heart grafts in Lewis rat (LEW) recipients treated with a short course of 15-deoxyspergualin (DSG), in a dose of 5 mg/kg daily beginning from day 4 of grafting, was markedly prolonged, with a mean survival time of 29.8 +/- 3.0 days. On day 20 after grafting, ...
Nozawa M - - 1992
Inbred, male Lewis rats underwent heterotopic heart allografting from F344 donor rats, or streptozocin (STZ)-induced diabetic Lewis rats underwent pancreas allografting with bladder drainage from F344 or ACI donor rats. A monoclonal antibody (MoAb) to intracellular adhesion molecule 1 (ICAM-1) was given i. p. (1.0 mg/kg) for 10 days, and ...
Hamano K - - 1991
Our previous paper reported that it was difficult to induce tolerance using donor specific transfusion (DST) in Lewis rats, while in DA and PVG rats it was possible to induce tolerance using DST. In this paper we investigated the effects of DST in a local graft versus host reaction (GVHR) ...
Kover K - - 1991
Due to concerns of cross-reactivity between renal and islet allografts in initiation of rejection, we determined the ability of donor-specific and third-party splenic dendritic cells (DCs) and thyroids (whole-organ transplant) to initiate rejection of established islet allografts. Purified islets from neonatal F-344 (RT1Lv1) rats were transplanted bilaterally under the kidney ...
Paineau J - - 1991
We studied the effect of rat rec-IFN-gamma, human rec-IL-2, and an IgG1 monoclonal antibody (DB1) directed against rat IFN-gamma on allograft survival in the rat in various experimental conditions. The DB1 monoclonal antibody did not prolong heart allograft survival in the (LEW/BN)F1 to LEW combination, even when used at high ...
Honey C R - - 1990
Prolonged immunosuppression with cyclosporin A allows survival of human xenografts in the rat Parkinsonian model but the drug has side effects. Ideally immunosuppression should be of short duration, to minimize the chance of infection, yet be capable of supporting long term survival of the transplanted tissue. We report that short ...
Shizuru J A - - 1990
In the present report a monoclonal antibody designated OX-38 directed against the rat CD4 molecule was tested for its ability to prolong the survival of heterotopic vascularized rat heart allografts transplanted across major histocompatibility barriers. Fluorescence-activated cell-sorter analysis showed that administration of OX-38 selectively depleted 80-95% of CD4+ cells from ...
Fang C H - - 1990
The wound contraction associated with a new grafting technique, transplantation of microskin autografts with overlaid skin allograft, was evaluated in a rat model. Male inbred Lewis rats were used as microskin autograft recipients while Buffalo rats were used as allogeneic skin graft donors providing a sheet allograft for overlay. This ...
Stone C D - - 1990
Prostaglandin E2 (PGE2) has been shown to a clear role in the suppression of immune responses after burn and trauma injury. This probably results from inhibition of interleukin-2 production. This study examined the effects of PGE2 in vivo on the survival of solid-organ allografts and in vitro on the rat ...
Yeh F L - - 1990
Wounds that were measured precisely 4 x 5 cm in size were created over the dorsal surfaces of rats. The defects were grafted with the use of either the microskin or Chinese technique of intermingled auto/allograft with an expansion ratio of 10:1. The size of the grafted wound of each ...
el Khatib H - - 1990
Aortic valve allografts have demonstrated excellent clinical performance, but the importance of antigenic differences between donor and recipient is largely unknown. To determine the antigenicity of aortic valve grafts, rat aortic valves with a short portion of thoracic aorta were transplanted into the abdominal aorta of recipient rats. Valves were ...
Ito T - - 1990
The cellular mechanisms of unresponsiveness induced with a combined KCl-extracted donor antigen (HAg) and CsA regimen were dissected by limiting-dilution (LD) assay. While untreated Wistar-Furth (WFu, RT1u) rats reject Buffalo (BUF, RT1b) heart allografts within a mean survival time of 6.6 +/- 0.5 days, recipients treated with 3 cycles of ...
Dymecki J - - 1990
We have evaluated the degree of genetic disparity that permits survival of intraventricular brain tissue grafts without additional immunosuppression. Fisher 344 rats (n = 100) with unilateral substantia nigra lesions were used as hosts. Donors consisted of Fischer 344 rats (isografts), Sprague-Dawley rats (allografts), mice, hamsters, and rabbits (xenografts). Grafts ...
Louie H W - - 1989
HHT was performed between minimally genetic mismatched inbred strains of rats. There was no evidence of rejection and immunosuppressive therapy was not instituted. Immunohistochemical analysis using peroxidase conjugated monoclonal anti-rat ASMA of cardiac arterioles in which AGAS developed revealed a decreased peroxidase signal. The data suggest that modulation of actin ...
Ferrero M E - - 1989
We studied the levels of nucleotides in peripheral blood and in spleen lymphocytes obtained from allografted rats. Four types of allografts were performed by using ACI rats (RT1a) as donors and Lewis rats (RT1l) as recipients: heart, pancreas, kidney and liver. Ungrafted Lewis rats were used as controls. Rejection time ...
Gulati A K - - 1989
The present study describes the usefulness of blood vessel allografts to repair gaps in rat peripheral nerve after immunosuppression with cyclosporine. Isogeneic strains of rats with known histoincompatibility were used for this study. A 10-mm gap was created in the peroneal nerve of host Fischer rats. The gap was bridged ...
Brundin P P Department of Medical Cell Research, University of Lund, - - 1989
Fetal mesencephalic mouse tissue, rich in dopamine neurons, was xenografted as a dissociated cell suspension into the striatum of rats with unilateral 6-hydroxydopamine induced lesions of the mesostriatal pathway. The rats were either assigned to a 10-day, 21-day or 42-day Cyclosporin A (CyA) immunosuppression scheme, or given no immunosuppression. The ...
Miyagawa S - - 1988
The mechanism of discordant xenograft rejection using the guinea pig-to-rat heart graft model was studied. In this model, we found that (A) Rejection occurred rapidly, in 17.5 +/- 8.3 min (mean +/- SD) (n = 8). (B) The graft survived longer when the recipient rat was pretreated with cobra venom ...
Suzuki S - - 1988
We investigated the effect of 15-deoxyspergualin (DSG) on graft rejection, starting administration at the onset of rejection and on the induction of immunologic unresponsiveness. Hearts from WKAH rats were transplanted into the neck of ACI rats. The energy metabolism of the grafted hearts was followed by 31P nuclear magnetic resonance ...
Selawry H P - - 1988
The mechanisms that control the privileged survival of intratesticular organ allografts are not known. It had been postulated that the elevated levels of testicular steroid hormones, testosterone and/or progesterone, could be responsible for the inhibition of the local immune response. The goals of this study were to examine intratesticular islet ...
Callanan D - - 1988
We have employed a rat model of orthotopic corneal transplantation to study the characteristics of rejection and development of systemic immunity in the host. Lewis (LEW) rats underwent a true penetrating keratoplasty using Wistar-Furth (WF) donor corneas. A rejection incidence of 55% with a mean survival time (MST) of 17.1 ...
Filipponi F - - 1988
A technique is described for orthotopic liver transplantation in the rat using polyethylene cuffs to re-establish subhepatic cava and portal vascular anastomoses. This procedure reduces the time of portal clamping, an important factor of survival. This technique was found to be reliable with a 72.9% long-term survival (more than 60 ...
Rodrigo J - - 1987
Recently, more attention is being paid to the treatment of the articular surface defect in the young, active individual. Resurfacing or "shell" allografts are being considered as one of the alternatives for treatment. The immune response by the host may be the chief obstacle to the successful use of fresh ...
Black K S - - 1987
This report is a partial review of our work to date concerning the use of cyclosporine and integumentary/musculoskeletal allografts for posttrauma tissue replacement. Our ultimate goals for such allografts are their lifesaving capabilities in addition to their utilization in functional and aesthetic surgical reconstructions. The potential for such a treatment ...
McCullagh P - - 1987
Lymphocytes exchanged rapidly and extensively between mutually tolerant, allogeneic rats following surgical parabiosis. Tolerated allogeneic cells persisted for an extended period in parabiotic partners after separation. A rapid exchange of cells was also observed between parabiosed syngeneic pairs of normal and allograft tolerant rats. This was accompanied by early termination ...
Knechtle S J - - 1987
Total lymphoid irradiation (TLI) has profound immunosuppressive actions and has been applied successfully to allotransplantation but not xenotransplantation. Cyclosporine (CsA) has not generally permitted successful xenotransplantation of organs but has not been used in combination with TLI. TLI and CsA were given alone and in combination to rats that were ...
Oesterwitz H - - 1987
Photochemical pretreatment of the kidney donor (Sprague-Dawley rats/SD) with 8-methoxypsoralen (8-MOP) and ex vivo longwave ultraviolet (UVA) irradiation of the kidney graft (PUVA therapy) significantly prolonged survival in allogeneic recipients (BD IX rats). After more than 100 days 7 long-term surviving PUVA-pretreated SD kidneys were retransplanted into BD IX rats. ...
Robert H - - 1986
The histological results of the implantation of twenty aortal prosthesis (6-6 polyamide, internal diameter 1.5 mm) in rats are presented. The success rate is 77%. Biological tolerance is remarkably good. After the first month, the formation of a continuous endothelial layer is noted. At three months, the structure of the ...
Selawry H - - 1985
Thirty-three male BB/W rats with diabetes of 11-145 days duration were divided into 3 groups: six received abdominal, intratesticular islet allografts and no immunosuppression posttransplantation; 15 were similarly grafted and in addition were given four injections of ALS regularly at 10-day intervals for 30 days after transplantation; and 12 rats ...
Pomposelli F - - 1985
Adult male (LewisXBrown Norway) F1 (LBNF1) rats received heterotopic small intestinal transplants from Lewis donors. Lewis-to-Lewis and LBNF1-to-LBNF1 isografts served as controls. All of the allograft recipients died after a median survival time of 16.2 days, but all isografted rats survived indefinitely. During the period of deterioration, allografted rats developed ...
Foegh M L - - 1985
A novel receptor antagonist, 3-hydroxymethyl-dibenzo (b,f) thiepin 5,5-dioxide (L-640,035) and the thromboxane synthase inhibitor, sodium (E) -3-(4-[3-pyridylmethyl phenyl]) -2-methyl-acrylate (OKY 1581) were evaluated for their effect in promoting the survival of cardiac allografts in Lewis rats that received cardiac allografts from Lewis x Brown-Norway F1 rats. Neither of these drugs ...
Inoue S - - 1985
We designed a simplified rat model to assess the effects of cyclosporine (CsA) on liver transplants. Auxiliary liver grafts consisting of 20 per cent of the whole liver were supplied with portal inflow and the bile was drained into the stomach. The cuff technique was used routinely for both end-to-end ...
Godden U - - 1985
During treatment of heart-grafted rats with cyclosporine, an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allograft and CsA for their generation and are ...
Mackinnon S E - - 1985
The nerve allograft response in a rat model is presented. The Lewis rat (RTI1) served as the recipient animal while Fischer rats (RTI1) and ACI rats (RTIa) provided the donor nerve allografts. A Lewis/Lewis autograft group was used as the control group. Histological and electrophysiological measurements of nerve regeneration were ...
Zalewski A A - - 1984
This study examined the effect of immunosuppressive treatment with cyclosporin A (Cy-A) on the survival of nerve allografts in sensitized rats. Nerve- or skin-sensitized untreated rats rejected a second nerve allograft of the same genotype as the first in an accelerated manner. In this situation, only a few host axons ...
Zernicki B - - 1984
Cortical and hippocampal EEG activity was analysed in 14 cerveau isole and 8 pretrigerninal rats. In the acute stage, waking EEG patterns were absent in the cerveau isole, whereas sleep EEG patterns were absent in the pretrigeminal preparations. However, already on the second day the EEG waking-sleep cycle recovered in ...
Houssin D - - 1983
In several combinations of inbred rats, liver allografts are spontaneously tolerated, and after a few weeks liver tolerant rats are in a state of donor-specific transplantation tolerance. In vivo and in vitro experiments were conducted to analyze the immunological status of LEW or BN rats with spontaneously tolerated (LEW X ...
Chow S P - - 1983
A segment of the femoral artery from a Sprague-Dawley rat was removed and freeze-dried. It was then used as a graft for a defect in the femoral artery of another rat. The femoral artery on the other side of this recipient rat had a similar grafting procedure using a segment ...
Caffee H H - - 1980
Expanded polytetrafluoroethylene (PTFE) was tested in rats as a microvascular synthetic graft. An inside diameter of 1.25 mm was used in the rat carotid artery, and various graft thicknesses were tried. Although several of the grafts remained patent, none of the samples tested were reliable enough to replace autologous vein ...
Oluwole S - - 1980
The present experiment was designed to study the relationship between rat heart allograft survival and passenger leukocyte depletion in donor-pretreated animals. Untreated Lewis rats served as recipients of cardiac allografts from treated Fischer rats. Passenger leukocyte depletion was assayed with indium-111 oxine-labeled leukocytes (predominantly lymphocytes) which were infused into donor ...
Doi K - - 1979
We did 97 limb homografts among histoincompatible rats, Wistar and Fischer 344 pairs, and we concluded as follows. 1. Using microvascular anastomoses, rats are technically, immunologically, and economically superior to other animals for the study of limb homografts. 2. The homografted legs in animals without the use of any immunosuppressive ...
Monden M - - 1978
Heart allografts from S-D to Wistar rats pretreated with 5 x 10(7) spleen cells taken from donor strain 1 or 2 weeks before, survived indefinitely. Sera taken from the pretreated rats showed high lymphocytotoxic titers and obvious blocking activity against LMC of immunized Wistar spleen cells. Even though the sera ...
Paris A M - - 1978
H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (P less than 0.01) at 105 ...
Nash J R - - 1978
Attempts to improve the induction of immunological enhancement of (AS X August)F1 pancreatic islet allografts in diabetic AS rats have been carried out. First, by treating the diabetic AS recipient with enhancing serum obtained from AS rats with functioning enhanced (AS X August)F1 islet allografts. In these rats on 1 ...
Wood R F - - 1977
Established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. Incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent Corynebacterium parvum proved ineffective. However, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four ...
Wright P W - - 1977
Mixed leukocyte culture reactivity was studied in adult W/Fu rats judged to be highly tolerant after the inoculation of (W/Fu X BN)F1 hybrid spleen and bone marrow cells at birth. Reactivity was observed in a majority of tolerant donors tested and documented by quantitative dose-response and kinetic studies. Allograft tolerance ...
Desi S B - - 1977
Lewis rats that were given injections of 10(6) to 10(8) (Lewis X Brown Norway) F1 hybrid bone marrow cells produce predominantly, if not exclusively, 19S lymphocytotoxic antibodies. A number of Lewis rats that received transplants of perfused renal allografts from bone marrow donors at, or near, the peak of IgM ...
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