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Wang Lei L Department of Orthopaedics, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, 100050, - - 2014
To investigate the effect of osteoporosis and intervertebral disc degeneration on the endplate cartilage injury in rats. A total of 48 female Sprague Dawley rats (3 months) were randomly divided into Groups A, B, C and D with 12 rats in each group. Osteoporosis and intervertebral disc degeneration composite model, ...
Kaija H H Department of Forensic Medicine, Institute of Diagnostics; Medical Research Center Oulu, Oulu University Hospital and University of - - 2014
Abstract Effects of hypothermia and rewarming on thrombomodulin, catecholamines and heat shock transcription factor 1 (HSF1) were studied in rats. The aims of the study were to clarify whether cold stress, under anaesthesia, is sufficient to change levels of thrombomodulin in healthy endothelium and in the circulation, and whether adrenaline, ...
Abdel-Rahim Emam A EA Department of Biochemistry, Faculty of Agriculture, Cairo University, Cairo, Egypt, - - 2014
The present work is aimed to investigate the toxicity of 1/20 LD50 of cadmium chloride (CdCl2) on male albino rats by oral ingestion and to determine the hepatoprotective effect of Solanum nigrum Linn (SN) dried fruits and their ethanolic extract against CdCl2 toxicity using biochemical parameters. Rats were divided into ...
Zapata-Sudo Gisele - - 2014
This study was designed to evaluate the cardioprotective effects of Euterpe oleracea Mart., popularly known as "acai," on rats subjected to myocardial infarction (MI). Hydroalcoholic extracts of acai were obtained from a decoction of the seeds. Two male Wistar rat groups were delineated: 1) the sham-operated group (control, n = ...
Ren Jiangxia J Department of Pharmacy, First Hospital of Lanzhou University, No.1 Donggangxi Road, Chengguan District, Lanzhou, 730000, Gansu, - - 2014
Many diabetes patients, especially the elder ones, suffered from hypertension simultaneously. Therefore, it is very likely that a large number of diabetes patients receiving metformin hydrochloride may simultaneously be given beta-blockers. Knowing that both metformin and atenolol are eliminated by organic cation transporter 2 (OCT2/SLC22A2) expressed in the renal basolateral membrane, ...
Ye Lian-Hua LH Department of Thoracic Surgery, Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, 650118, Yunnan, China, - - 2014
In this study, a central venous catheter (CVC)-associated infection model was established in rats to investigate and evaluate the effect of biofilms on the virulence of the pathogens. Twenty-four adult SD rats were randomly divided into biofilm positive (BF+) and biofilm negative (BF-) groups to be challenged with strains of ...
Crescenzo Raffaella - - 2014
We considered of interest to evaluate how aging affects mitochondrial function in skeletal muscle. We measured mitochondrial oxidative capacity and proton leak, together with lipid oxidative damage, superoxide dismutase specific activity and uncoupling protein 3 content, in subsarcolemmal and intermyofibrillar mitochondria from adult (six months) and old (two years) rats. ...
Sayin Aslıhan A Psychiatry Department of Gazi University Hospital. Electronic address: - - 2014
In rats, hormonal fluctuations during the estrus cycle may have numerous behavioral and neurobiological consequences. The aim of this study was to investigate the effects of estrus cycles and citalopram on behavior, ultrasonic vocalizations, anxiety levels, and c-fos expression in rats. With this aim, the rats were grouped into two: ...
Oh Kyung Chul KC Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of - - 2014
The purpose of this study was to determine the effects of alendronate on the peri-implant bone in rat maxillae with the aid of micro-computed tomographic, histologic, and biochemical analyses. Thirty-six male Sprague-Dawley rats were used. After extraction of the maxillary first molars, each rat was given periodic subcutaneous injections of ...
Aydin Cemalettin C Inonu University, Turgut Ozal Medical Center, Department of General Surgery, Malatya, - - 2014
The liver is the most frequent organ for placement of hydatid cyst disease. All known protoscolicidals that are used for echinococcus degeneration have a risk of caustic secondary sclerosing cholangitis. The cetrimide-chlorhexidine combination is an effective protoscolicidal agent for treatment of hydatid liver cysts. The aim of this experimental study was ...
Liao Chu-Hang CH Oral and Maxillofacial Surgery of Sichuan Provincial Academy of Medical Sciences, Sichuan Provincial People's Hospital 610072, Chengdu, - - 2014
To simulate the expression of TNF-α and PGE2 of periodontal tissues in rat periodontitis model. 40 Wistar rats were randomly divided into the periodontitis group and the control group (n=20). After the successful establishment of periodontitis rat model, raising for six weeks before the animals were sacrificed. The periodontal tissues ...
Yang Yongxia Y School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China. - - 2014
Insulin resistance (IR) is a common risk factor for the development of metabolic diseases, and has gradually become a hot issue for research. It was reported that excessive feeding with high fructose induced insulin resistance in both humans and rats. The aim of this study was to investigate the progression ...
Papageorgiou Peter C PC aHeart and Stroke/Richard Lewar Centre of Excellence bDepartment of Medicine, University Health Network and Mount Sinai Hospital cDepartment of Physiology, University of Toronto, Toronto, Ontario, - - 2014
Activated coagulation Factor XII (FXIIa) infusion increases peripheral resistance (TPR) and mean arterial pressure (MAP) of Brown Norway but not plasma kininogen deficient Brown Norway Katholiek (BNK) rats. FXIIa concentrations are elevated in hypertensive end-stage renal disease patients receiving conventional haemodialysis (CHD). Conversion to nocturnal haemodialysis (NHD) lowers peripheral resistance ...
Magalhães Cibelle Ribeiro CR Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University - - 2014
To assess liver regeneration in rats after 60% hepatectomy with and without supplementation of L-glutamine through liver weight changes, laboratory parameters and histological study. 36 male rats were divided into two groups: glutamine group and control group. Each group was subdivided into three subgroups, with death in 24h, 72h and ...
Sawamoto Kazuki K Department of Pharmacy, Kanazawa University - - 2014
  A retrospective analysis suggested that blood tacrolimus concentrations were consistent among patients with a body mass index (BMI) < 18.5 (lean), normal (≥18.5 and <25) and ≥ 25 (overweight or obese). The average maintenance dose of tacrolimus in patients with BMI ≥ 25 were significantly lower compared with that in ...
Pan Feng F Department of Andrology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China; Department of Andrology, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, - - 2014
Aging-related erectile dysfunction (A-ED) is a neurovascular and refractory disorder with complicated pathophysiological mechanisms and a high prevalence. MicroRNAs (miRNAs), which modulate a variety of cell functions, may be involved in the pathophysiological processes of this disorder. To investigate the miRNA profile in the corpus cavernosum (CC) of aging rats ...
Nakagami Hironori H Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, - - 2014
Diabetes mellitus, hypertension and metabolic syndrome are major risk factors for the occurrence of cardiovascular events. In this study, we used spontaneous hypertensive rat (SHR)/NDmcr-cp (cp/cp) (SHRcp) rats as a model for metabolic syndrome to examine the effects of dipeptidyl peptidase (DPP)-4 inhibition on hypertension, glucose metabolism and endothelial dysfunction. ...
Tresguerres Isabel F IF Complutense University, Medicine and Oral Surgery, Madrid, Spain ; - - 2014
Introduction: Previous studies have shown that melatonin, an antioxidant molecule secreted from the pineal gland, is a positive regulator of bone mass. However, melatonin potential effects on bone mass have never been investigated in old population yet. The aim of this study was to assess the effects of dietary melatonin ...
Zheng Yanyan Y Department of Pediatrics, Xinqiao Hospital, The Third Military Medical University, Chongqing, 400037, People's Republic of - - 2014
We aimed to investigate the effects of environmental noise exposure on the growth and neuropsychological development in neonatal rats. Twenty-four postnatal 7-day-old Sprague-Dawley rats were randomly assigned into control, high-noise and reduced noise groups. The rats in the high-noise group were exposed to 90 dB white noise, and those in ...
Wanek Justin J Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, - - 2014
The purpose of the study is to report global measurements of inner retinal oxygen delivery (DO2_IR) and oxygen metabolism (MO2_IR) in streptozotocin (STZ) diabetic rats. Phosphorescence lifetime and blood flow imaging were performed in rats 4 (STZ/4 wk; n = 10) and 6 (STZ/6 wk; n = 10) weeks following ...
Rivera DA Rendon DR Laboratory of Biophysics, School of Physics, Faculty of Sciences, National University of Colombia-Medellin Branch, Antioquia, - - 2014
The mitochondrial oxidative phosphorylation system was studied in liver and heart homogenates after treatment of rats with benznidazole. The drug was given by oral gavage to adult female Wistar rats for 9 consecutive days (100 mg benznidazole/kg body weight as a daily dose). The mitochondrial state 4 and state 3 ...
Cintra Luciano Tavares Angelo LT Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), R. José Bonifácio, Araçatuba, São Paulo, 1193, Brazil, - - 2014
This study aimed to evaluate the influence of apical periodontitis (AP) and/or periodontal disease (PD) on serum interleukin-17 (IL-17) levels in a rat model of diabetes mellitus (DM). Eighty male Wistar rats were divided into eight groups of ten animals each: normoglycemic, AP, PD, AP+PD, DM, DM+AP, DM+PD, and DM+AP+PD. ...
Hakim Lukman L Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Urology, Airlangga University School of Medicine/Dr. Soetomo General Hospital, Surabaya, - - 2014
We evaluated external urethral sphincter (EUS) function using high-frequency micro-ultrasound (US) in rats that were either uninjured (Control, C) or underwent vaginal distension (VD) as a substitute for vaginal birth injury induced stress urinary incontinence (SUI). Thirteen female nulliparous Sprague-Dawley rats of 12 weeks were divided into two groups, either ...
Suzuki Tomoyasu T Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, - - 2014
Anemia and relative iron deficiency (RID) are prevalent in patients with heart failure (HF). The etiology of anemia and RID in HF patients is unclear. Hepcidin expression may be closely related to anemia and RID in HF patients. Although hepcidin is produced mainly by the liver and the most frequent ...
Maskali Fatiha F GIE-Nancyclotep, CHU-Nancy, 5, rue du Morvan, 54000, Vandoeuvre-les-Nancy, France, - - 2014
Spontaneously hypertensive heart failure rats (SHHF) appear to constitute an original model for analyzing the evolution of the metabolic syndrome towards heart failure. This study aimed to characterize early cardiac dysfunction and remodeling in SHHF rats: (1) as compared with spontaneously hypertensive rats (SHR) and with a control group of ...
Onwuli Donatus Onukwufor DO Chemical Pathology Unit, Department of Medical Laboratory Science, Faculty of Science, Rivers State University of Science and Technology, Nkpolu Oroworukwo, Port Harcourt, Rivers State, - - 2014
The antihyperglycaemic activity of Tetracarpidium conophorum nut (walnut) was investigated in albino rats. A total of 20 albino rats were used for the study. The rats were divided into five groups (A-E) of four rats each. Diabetes were induced in the rats except four which served as the positive control ...
Sun Peifeng P Shandong University, Jinan 250100, China ; Department of Orthopedics, Chinese People's Liberation Army 401 Hospital, Tsingtao, Shandong 266071, - - 2014
Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy. Recently, EF is thought to cause recurrent postoperative pain after laminectomy. Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties. The object of this study was to investigate the effects of resveratrol on ...
Hu Dou-Dou DD Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, - - 2014
Diffraction enhanced imaging (DEI) is a synchrotron radiation X-ray phase-contrast imaging technique that can better reveal the microstructure of biological soft tissues than conventional X-rays. The aim of this study is to investigate the angio-architectural changes of the liver during fibrosis, cirrhosis and its subsequent regression by applying synchrotron radiation ...
Mahmoodi Mohammad Reza MR Department of Nutrition and Physiology Research Center, School of Health, Kerman University of Medical Sciences, Kerman, - - 2014
The present study designed to test effects of defatted soy-fortified wheat bread on the organoleptic properties as well as influences on rat growth rate. Defatted soy flour (DSF) was blended with wheat flour with extraction rate of 82-84% at 3, 7, and 7% levels plus 3% sugar. Bread produced with ...
Buzzacott Peter P 0000-0002-5926-1374 Laboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, 6 avenue Le Gorgeu, CS 93837, 29200 Brest Cedex 3, - - 2014
In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. ...
Ronot Maxime M Department of Radiology, Beaujon University Hospitals Paris Nord Val de Seine, Clichy, France; University Paris Diderot, Sorbonne Paris Cité, France; IPMA, INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon, Paris, - - 2014
To assess in a high-resolution model of thin liver rat slices which viscoelastic parameter at three-dimensional multifrequency MR elastography has the best diagnostic performance for quantifying liver fibrosis. The study was approved by the ethics committee for animal care of our institution. Eight normal rats and 42 rats with carbon ...
Yang Heng H State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, - - 2014
We derived mesenchymal stem cells (MSCs) from rat induced pluripotent stem cells (iPSCs) and transduced them with tumor necrosis factor alpha-stimulated gene-6 (TSG-6), to test whether TSG-6 overexpression would boost the therapeutic effects of iPSC-derived MSCs in experimental periodontitis. A total of 30 female Sprague-Dawley (SD) rats were randomly divided ...
Zhou Donglei D Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, - - 2014
We aimed to evaluate the therapeutic efficacy on weight control by different bariatric surgeries and investigate the ghrelin and obestatin changes after these surgeries in obesity and nonobese type 2 diabetes mellitus (T2DM) rats. Obese rats were randomly assigned to receive sleeve gastrectomy (SG, n = 8), minigastric bypass (MGBP, ...
Tsumiyama Wakako W Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Japan ; Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, - - 2014
[Purpose] The purpose of the present study was to investigate if lactate thresholds in rats could be accurately determined during downhill running in rats. [Subjects] Twenty-four female Wistar rats were used in this study. Rats were randomly divided into two groups: the level running group and downhill running group. [Methods] ...
Shi Yinghua Y College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, - - 2014
To investigate the cholesterol-lowering effects of alfalfa saponin extract (ASE) and its regulation mechanism on some key genes involved in cholesterol metabolism, 40 healthy 7 weeks old male Sprague Dawley (SD) rats were randomly divided into four groups with 10 rats in each group: control group, hyperlipidemic group, ASE treatment ...
Wei Sheng S Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China - - 2014
Background Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as major depression. It is also well known that the resident intruder paradigm (RIP) results in aggressive behavior in male rats. However, it is not known how resident intruder paradigm-induced aggression affects depressive-like ...
Aydin Nihal Bakirkalay NB Department of Chest Diseases, Necmettin Erbakan University, Meram Medical faculty, Konya, - - 2014
Movement disorders and atrophy occur in the diaphragm, the most important muscle of respiration, because of mechanical ventilation (MV). In this animal model, we aimed to evaluate the effect of intravenous theophylline administration on the prevention of mechanical ventilation-induced diaphragmatic atrophy. In our study, 30 healthy male Sprague-dawley rats were ...
Ahmed Zia Z Department of Pharmacy Hazara University, Havelian Campus, Abbottabad, Khyberpukhtunkhaw, - - 2014
Muslims throughout the world observe dawn to dusk fast in the month of Holy Ramadan. This study aims to investigate the effect of fasting on serum lithium levels in an animal model under typical conditions of Ramadan. Animals were categorized into oral and intraperitoneal groups. Each group was divided into ...
Mamikutty Norshalizah N 0000-0001-9776-3810 Anatomy Discipline, Surgical Science Cluster, Medical Faculty, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor, - - 2014
Background. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. Aims. To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW) in male Wistar rats. Methods. Eighteen male Wistar rats were fed ...
Arai-Nunota Noriko N Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, - - 2014
Oral phosphate loading and calcitriol stimulate Fibroblast growth factor 23 (FGF23) secretion, but the mechanisms underlying the stimulation of FGF23 remain to be studied. We compared the effect of intravenous phosphate loading with that of oral loading on FGF23 levels in normal and 5/6 nephrectomized uremic rats. Uremic rats (Nx) ...
Erbaş Oytun O Department of Physiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, - - 2014
The aims of the study were to evaluate (1) detection of cognitive function changing in rat with hepatosteatosis model and (2) evaluate the effect of GLP-1 analog (exenatide) on cognitive function in hepatosteatosis. In the study group, 30% fructose was given in nutrition water to perform hepatosteatosis for 8 weeks ...
Haouem Samir S Departement de Physiologie, Faculté de Médecine de Monastir, 5019 Monastir, - - 2013
The aim of this study was to examine the effects of cadmium (Cd), incorporated in radish bulbs, on malondialdehyde and glutathione levels and on superoxide dismutase activity in the liver, kidneys and testes of male rats. The control animals were given diet containing ordinary radish bulbs for 4, 8 and ...
Olaiya Co C Department of Biochemistry, University of Ibadan, Ibadan, - - 2013
Hypercholesterolemia is a condition characterised with high level of cholesterol in the blood. The effect of ethanolic extract of Buchholzia coriacea (EEBC) on the lipid profile levels and extent of lipid peroxidation in hypercholesterolemic albino rats was investigated in this study. Thirty albino rats were divided into six different groups ...
Domingues N N Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Portugal; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, - - 2013
The bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has shown anti-diabetic effects by in vitro studies in Wistar (W) rat adipocytes and in vivo in obese Zucker rats. The aim of this work is to confirm the therapeutic properties of VO(dmpp)2 in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. An in vivo study was carried ...
Lang Charles H - - 2013
The purpose of this study was to assess whether the deleterious effect of chronic alcohol consumption differs in adult and aged female rats. To address this aim, adult (4 m) and aged (18 m) F344 rats were fed a nutritionally complete liquid diet containing alcohol (36% total calories) or an ...
Zhu Wei - - 2013
Proliferative vitreoretinopathy (PVR) is one of the most common causes for failed retinal detachment surgeries. The aim of the present study was to investigate the role of insulin‑like growth factor‑binding protein‑6 (IGFBP‑6) in PVR using rat models and its effects on retinal pigment epithelial‑J (RPE‑J) cells. PVR Wistar rat models ...
Kumar Dileep - - 2013
There is much evidence linking the involvement of oxidative stress in the pathogenesis of aging. Paraoxonase 1 (PON1) is an HDL-associated antioxidant enzyme that inhibits the oxidative modification of low-density lipoproteins (LDL). We have investigated the changes in plasma PON1 activity, LDL oxidation, radical scavenging activity and lipid peroxidation in ...
Abuelgassim Abuelgassim O AO Department of Biochemistry, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi - - 2013
The present investigation was performed to study the effects of Acacia nilotica Delile (Fabaceae) fruit extract on serum concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and glucose in control and alloxan-induced diabetic rats. The rats were divided into four groups: Normal Control Rats (NC), normal control ...
Hiraoka Miki - - 2013
This study was conducted to elucidate pathophysiological roles of the lysosomal phospholipase A2 (LPLA2), a phospholipid-degrading enzyme, of the aqueous humor (AH) in uveitis using an animal model and clinical specimens. Endotoxin-induced uveitis (EIU) was induced by subcutaneous injections of lipopolysaccharide from Escherichia coli to seven-week-old male Lewis rats. Inflammation ...
Xia Xianyin - - 2013
Purpose: To investigate the effect of Vitapex on the healing of periapical lesions and the expression of bone morphogenetic protein (BMP-2) during the periapical bone regeneration. Materials and Methods: Periapical lesions were induced in Sprague-Dawley (S-D) rats by an occlusal pulp exposure in the mandibular first molars and were verified ...
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