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Wheeler R R RR Laboratory Animal Resource Center, School of Medicine, Indiana University, Indianapolis, Indiana, - - 2014
Current regulations emphasize that good husbandry practices allow animals to engage in species appropriate postural adjustments without touching the enclosure walls. This study evaluated the well-being of rats housed in a commercially available multilevel rat caging system, with or without access to the upper level of the caging. The evaluation ...
Urbach Yvonne K YK Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, - - 2014
The need for improving throughput, validity, and reliability in the behavioral characterization of rodents may benefit from integrating automated intra-home-cage-screening systems allowing the simultaneous detection of multiple behavioral and physiological parameters in parallel. To test this hypothesis, transgenic Huntington's disease (tgHD) rats were repeatedly screened within phenotyping home-cages (PhenoMaster and ...
Gong Xiao-Hong XH The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, People's Republic of - - 2014
In the study, it was hypothesized that Rhubarb Anthraquinones synergistically enhanced the purgative effect on constipation rat from the direct and indirect pathway at the same time. A validated HPLC method was successfully applied to elucidate the synergism mechanism from pharmacokinetics aspect after oral administration of Rhubarb extract with a ...
Folwarczna J J Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland. - - 2014
An example of a medicinal plant with numerous potential activities is fenugreek (Trigonella foenum-graecum L.). The aim of the present study was to investigate the effects of fenugreek seed on bone mechanical properties in rats with normal and decreased estrogen level (developing osteoporosis). The experiments were carried out on 3-month-old ...
Hidaka Kouki K Departments of *Periodontal Regeneration; †Oral & Maxillofacial Rehabilitation; ‡Radiopraxis Science; §Faculty of Dentistry; ‖Pulp Biology; ¶Microbiology; **Cariology and Restorative Dentistry; ††Oral Science-Molecular and Cellular Biology of Mineralized Tissues, Kanagawa Dental University Graduate - - 2014
We proposed a site-specific mechanism of mouse mandibular bone remodeling in which osteoblasts express RANKL and BCL-2 only when mechanically loaded. Gene expression is regulated by α5β1 integrin, as a cellular defense mechanism against exposure to oral bacteria that would otherwise induce bone resorption through production of inflammatory cytokines (Exp ...
Folwarczna Joanna J Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Katowice, - - 2014
Trigonelline (1-methylpyridinium-3-carboxylate), an alkaloid present in coffee and fenugreek seed, has been reported to exhibit phytoestrogenic activity. The aim of the present study was to investigate the effects of trigonelline on bone mechanical properties of rats with normal estrogen level and estrogen deficiency (developing osteoporosis). The experiments were performed on ...
Su Cheng-Kuan CK Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, 30013 Hsinchu, - - 2014
With the increasing prevalence of silver nanoparticles (AgNPs) in various products, whether such AgNPs will introduce new injury mechanisms from new pathologies remains to be determined. From the toxicokinetic viewpoint, it is vital to have in-depth knowledge of their in vivo transport kinetics and extravasation phenomenon. By combining push-pull perfusion ...
Shimazu Rintaro R Department of Otolaryngology, Head & Neck Surgery, Faculty of Medicine, Saga University, Saga, - - 2014
This study was undertaken to elucidate the mechanisms underlying laryngeal granuloma formation in a rat model of gastroesophageal reflux disease (GERD) with mechanically injured vocal cord mucosa. The rat model of GERD was surgically created by tying the pyloric sphincter and ligating the transitional region between the forestomach and the ...
Liu Te T Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, - - 2014
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on ...
Coria Santiago M SM Department of Psychobiology, School of Psychology, UNED, C/ Juan del Rosal 10, 28040 Madrid, Spain. Electronic address: - - 2014
The Lewis (LEW) and Fischer 344 (F344) rat strains have been proposed as a model to study certain genetic influences on drug use. These strains differ in terms of the self-administration of several drugs, and in their expression of various components of the dopaminergic, glutamatergic, GABAergic and endogenous opioid neurotransmitter ...
Hassouna A A Cairo University Departments of Medical Biochemistry, Faculty of Medicine Cairo - - 2014
Estrogen (E2) and progesterone (P) hormones have a pro-inflammatory and an anti-inflammatory role under different conditions. The current study explored this phenomenon in the context of septic inflammation.
Zhou Ren Ou RO Department of Hepatobiliary Surgery, Urumqi General Hospital of Lanzhou Military Region of PLA, Urumqi 830000, PR China; Medical College of Shihezi University, Shihezi 832000, PR - - 2014
Heatstroke is one of the most common clinical emergencies. Heatstroke that occurred in a dry-heat environment such as desert is usually more seriously effective and often leads to death. However, the report of the pathophysiologic mechanisms about heatstroke in dry-heat environment of desert has not been seen. Our objectives are ...
Sarwa Khomendra Kumar KK Department of Pharmaceutical Sciences, Dibrugarh University , Dibrugarh, Assam , India - - 2014
Abstract In the present study, the biopotential of capsaicin (an active principle of capsicum) as a topical antiarthritic agent was studied in arthritic rats. Transfersomal vesicular system was employed for the topical administration of capsaicin in experimental rats. The characterization of prepared capsaicin-loaded transfersomes reveals their nano size (94 nm) with ...
Chalmey Clémentine - - 2014
[This corrects the article on p. e82175 in vol. 8.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0097458.].
Zhang Bin B Bin Zhang, Cheng-Gang Zhang, Quan-Bo Zhou, Wei Chen, Zhi-Yong Wu, Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2013
To evaluate the effects of estrogen (E2) on systemic and splanchnic hyperdynamic circulation in portal hypertensive rats. Fifty castrated female Sprague-Dawley rats were divided into five groups: sham operation (SO), partial portal vein ligation (PPVL) + placebo (PLAC), PPVL + E2, PPVL + ICI and PPVL + E2 + ICI. ...
Thomas H G - - 2013
Sociality in mole rats has been suggested to have evolved as a response to the widely dispersed food resources and the limited burrowing opportunities that result from sporadic rainfall events. In the most arid regions, individual foraging efficiency is reduced, and energetic constraints increase. In this study, we investigate seasonal ...
Kirschneck Christian - - 2013
Rat models currently available for analysis of orthodontic tooth movement often lack differentiated, reliable and precise measurement systems allowing researchers to separately investigate the individual contribution of tooth tipping, body translation and root torque to overall displacement. Many previously proposed models have serious limitations such as the rather inaccurate analysis ...
Shinozaki Munehisa - - 2013
In the research for the treatment of spinal cord injury (SCI), the evaluation of motor function in model rats must be as objective, noninvasive, and ethical as possible. The maximum speed and acceleration of a mouse measured using a SCANET system were previously reported to vary significantly according to severity ...
Luo Cheng - - 2013
Total paeony glucosides (TPG) extracted from the roots of Radix Paeoniae Rubrae, have been approved for the therapy of rheumatoid arthritis by the State Food and Drug Administration. We previously demonstrated the myocardial protective effects of TPG in both isoprenaline-induced myocardial ischemia rat and acute myocardial infarction rat. However, the ...
Shurlygina A V - - 2013
We studied the influence of abnormal illumination regimen on cell composition of the central and peripheral organs of the immune system in ISIAH rats and control WAG rats. In ISIAH rats, 24-h illumination for 14 days led to more pronounced inhibition of cell proliferation and differentiation in the thymus and ...
Li Ming M Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education, Institute of Psychology, Southwest University, Chongqing, PR China; Department of Psychology, University of Nebraska-Lincoln, USA. Electronic address: - - 2013
Escape from fear (EFF) is an active response to a conditioned stimulus (CS) previously paired with an unconditioned fearful stimulus (US), which typically leads to the termination of the CS. In this paradigm, animals acquire two distinct associations: S-S [CS-US] and R-O [response-outcome] through Pavlovian and instrumental conditioning, respectively. The ...
Folwarczna Joanna - - 2013
SCOPE: Caffeine, a methylxanthine present in coffee, has been postulated to be responsible for an increased risk of osteoporosis in coffee drinkers; however, the data are inconsistent. The aim of the present study was to investigate the effects of a moderate dose of caffeine on the skeletal system of rats ...
Uzunoglu Sernaz - - 2013
Abstract This study aimed to compare the efficacy of topical dimethyl sulfoxide (DMSO), intralesional and systemic carnitine as monotherapy and in combination against ulceration in rats induced by intradermal doxorubicin extravasation. Sixty-nine 3-month-old male Wistar albino rats, weighing between 200-225 g, were used in this study. Rats were applied monotherapy ...
Rizza Robert - - 2013
Background: Axial loading of vertebral bodies have been shown to modulate growth. Growth is modulated by increased compressive forces and reduced by loading and distraction. However, investigation of growth and the mechanics imposed on these bodies by torque are few especially in examination of the growth plate. The purpose of ...
Blasio Angelo - - 2013
Binge eating disorder is an addiction-like disorder characterized by excessive food consumption within discrete periods of time. This study was aimed at understanding the role of the opioid system within the medial prefrontal cortex (mPFC) in the consummatory and motivational aspects of binge-like eating. For this purpose, we trained male ...
Sládek Martin - - 2013
The functional state of the circadian system of spontaneously hypertensive rats (SHR) differs in several characteristics from the functional state of normotensive Wistar rats. Some of these changes might be due to the compromised ability of the central pacemaker to entrain the peripheral clocks. Daily body temperature cycles represent one ...
Zhang Xingguang X Beijing Military General Hospital, No. 5 Nan Men Cang, Dongcheng Distrct, Beijing 100700, P.R. - - 2013
Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the ...
Raczak-Gutknecht Joanna - - 2013
Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At first it was postulated that these effects are mediated via α2-adrenoceptors exclusively. Clonidine is well known as a model agent to produce pupillary dilation in rats. However, it became obvious later that clonidine-like imidazol(in)e ...
Li L - - 2013
Bone's adaptability to loading depends upon the process of bone remodeling. This adaptive mechanism is restricted in postmenopausal osteoporosis. Differentiation of mesenchymal stem cells (MSCs) is crucial to bone remodeling and regeneration. It is well accepted that mechanical loading influences the fate of MSC differentiation. The aim of this study ...
Vaira Sergio - - 2012
Leptin, a cytokine-like hormone secreted mainly by adipocytes, regulates various pathways centered on food intake and energy expenditure, including insulin sensitivity, fertility, immune system, and bone metabolism. Here, using zinc finger nuclease technology, we created the first leptin knockout rat. Homozygous leptin null rats are obese with significantly higher serum ...
Nishikawa Sumio - - 2012
The localization of the planar cell polarity proteins Vang12, frizzled-3, Vang11, and Celsr1 in the rat incisors was examined using immunocytochemistry. The results showed that Vang12 was localized at two regions of the Tomes' processes of inner enamel-secretory ameloblasts in rat incisors: a proximal and a distal region. In contrast, ...
Muto Taro - - 2012
Tooth enamel is the hardest organ in the body. In rodent incisor, the enamel is exclusively produced by ameloblasts with yellowish-brown pigmentation, indicating normal enamel formation. However, the molecular mechanisms of ameloblast differentiation and amelogenesis are not fully understood. Specificity protein (Sp) 6 has been reported as one of the ...
Normand Jean-Marie - - 2012
Immersive virtual reality (IVR) typically generates the illusion in participants that they are in the displayed virtual scene where they can experience and interact in events as if they were really happening. Teleoperator (TO) systems place people at a remote physical destination embodied as a robotic device, and where typically ...
Maybhate Anil A Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA. - - 2012
Neuroprotective effects of hypothermia are well documented in many injuries of the central nervous system in animal models as well as clinical studies. However, the underlying mechanisms are not fully understood. An important yet unexplored background issue is the effect of hypothermic cooling on the regional functionality of the healthy ...
Park Yun S YS Laboratory for Restorative Neurotechnology, Brown University, Providence, RI 02912, USA. - - 2012
We present an enhanced algorithm for seizure onset and offset detection in rats' ECoG. Because a seizure in rats' ECoG evolves much more stereotypically than that in human, analyzing seizure evolution in rats' ECoG is advantageous to understanding the evolution process. The proposed algorithm outperforms a prior automatic seizure detection ...
Tooley Katie L - - 2011
Preventative or adjunctive agents for the amelioration of small intestinal chemotherapy-induced mucositis are not currently available for clinical use. We have previously demonstrated that oral ingestion of Streptococcus thermophilus (TH-4) partially attenuated chemotherapy-induced mucositis in the rat. Here we assess the effects of TH-4 on small intestinal damage and tumor ...
Giral Marta - - 2011
Some experimental procedures are associated with placement of animals in wire-bottom cages. The goal of this study was to evaluate stress-related physiological parameters (heart rate [HR], body temperature [BT], locomotor activity [LA], body weight [BW] and food consumption) in rats under two housing conditions, namely in wire-bottom cages and in ...
Karas Joshua R - - 2011
BACKGROUND: The validity of current animal colon cancer models is questionable. This study was performed to evaluate whether colonoscopic injection of a murine colon cancer cell line into the cecal wall of immunocompetent rats leads to a solid tumor. METHODS: A bolus of bowel prep was given to BD-IX rats. ...
Khatiwada Janak - - 2011
Experimental as well as epidemiologic studies in human populations provide evidence that consumption of phytochemicals reduces the incidence of degenerative diseases. Green tea (GT) catechins are known for their antioxidative potential. Phytic acid (PA) also acts as a natural antioxidant and may have numerous health benefits. This experiment was designed ...
Li Yanning - - 2011
OBJECTIVES: Constipation can adversely affect children's health, with disorder of host immunity and enhanced oxidative stress. As nondigestible carbohydrates, the prebiotics can beneficially affect the host with constipation. However, whether the prebiotics have effects on the content of intestinal secretory IgA (sIgA), and the contents of superoxide dismutase (SOD) and ...
Tjong Yungwui Y School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. - - 2011
Coptis chinensis rhizomes (Coptidis Rhizoma, CR), also known as "Huang Lian", is a common component of traditional Chinese herbal formulae used for the relief of abdominal pain and diarrhea. Yet, the action mechanism of CR extract in the treatment of irritable bowel syndrome is unknown. Thus, the aim of our ...
Umesalma Syed - - 2011
Colon cancer is the third most malignant neoplasm in the world and chemoprevention through dietary intervention is an emerging option to reduce its mortality. Ellagic acid (EA) a major component of berries possesses attractive biological deeds. This study is investigated the in vivo effect of ellagic acid in fostering apoptosis ...
Miri Hamidreza - - 2011
Gastric cancer is often diagnosed at advanced stages and there is no accurate method for its screening and diagnosis, especially in small animals. Here, we explain the application of B-mode ultrasound imaging (BMUI) for screening of gastric changes in the rat. Thus, male Albino Wistar rats, weighing 100-120 grams were ...
Haslam Iain S - - 2011
A clear understanding of oral drug absorption is an important aspect of the drug development process. The permeability of drug co mpounds across intact sections of small intestine from numerous species, including man, has often been investigated using modified Ussing chambers. The maintenance of viable, intact tissue is critical to ...
Morales Walter - - 2011
BACKGROUND: Campylobacter jejuni has been implicated in the pathogenesis of post-infectious irritable bowel syndrome (PI-IBS) in humans, effects which may be because of cytolethal distending toxin (CDT). In this study, we characterized both acute and chronic-phase histological changes of the small bowel in rats exposed to wild-type C. jejuni 81-176, ...
Jan Kuo-Ching - - 2011
Sesame seeds (Sesamum indicum, L.) are unique because of potent and various physiological activities imparted by their bioactive lignans. This investigation studied the intestinal distribution and excretion of sesaminol in Sprague Dawley (SD) rats. In order to investigate the distribution of sesaminol (per oral 220 mg/kg), the changes in concentration ...
Doi Hiroshi - - 2011
PURPOSE: The purpose of the present study was to standardize the experimental rat model of radiation proctitis and to examine the efficacy of polaprezinc on radiation proctitis. METHODS AND MATERIALS: A total of 54 female Wistar rats (5 weeks old) were used. The rats were divided into three groups: those ...
Song Rui - - 2011
Through investigation of the metabolism of rhubarb extract by rat intestinal bacteria, a total of 14 components in rhubarb extract were found to be biotransformed. These components included aloe-emodin-O-glucosides, emodin-O-glucosides, chrysophanol-O-glucosides, physcion-O-glucosides and the corresponding aglycones. Rhein also could be biotransformed by rat intestinal bacteria. Twelve major metabolites were detected ...
Nikitenko V I VI Department of Trauma Surgery, Orthopaedics and Millitary - - 2011
To study the phenomenon of asymptomatic penetration of bacteria from the gastrointestinal tract into various tissues of healthy rats and rats with skin wounds and closed fractures at different doses and with different species of bacteria. Healthy rats and rats with full-thickness skin wounds and closed femoral fractures were given ...
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