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Jana Sougata S Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol-713301, W.B., INDIA. Electronic address: - - 2014
In the present work, testosterone-loaded alginate nanocapsules were prepared by in situ nanoemulsification-polymer cross-linking method. Drug loading, particle size (diameter), polydispersity index and zeta potential of these alginate nanocapsules were measured 30.22±1.90%, 34.53±1.72nm, 0.22±0.04 and-5mV, respectively. The pharmacokinetic evaluation of these nanocapsules was also performed in female Sprague Dawley rats. ...
Tsyganova N A NA Institute of Medicine, Ecology, and Physical Education, Ul'yanovsk State University, Ulyanovsk, - - 2014
Penetration of pegylated (enveloped in polyethylene glycol) gold nanoparticles 5 and 30 nm in diameter through the placental barrier was studied in pregnant rats injected intravenously with these particles in a dose of about 0.8 mg Au/kg on day 10 of gestation. The particles were visualized in tissues by silver ...
Cai Elijah Zhengyang EZ Department of Surgery, National University Health System, - - 2014
Burn infliction techniques are poorly described in rat models. An accurate study can only be achieved with wounds that are uniform in size and depth. We describe a simple reproducible method for creating consistent burn wounds in rats. Ten male Sprague-Dawley rats were anesthetized and dorsum shaved. A 100 g ...
Li Congsheng C College of Computer Science and Technology, Beijing University of Science and Technology , Beijing , China - - 2014
Abstract Rats' exposure to electromagnetic pulses (EMPs) has been conducted using an EMP simulator for various biological endpoints. In contrast, information about the EMP energy distribution and its variability in rats is lacking. EMPs are signals with spectrum concentrating in several hundred MHz, leading to EM absorption patterns different from ...
Fraga Sónia S REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: - - 2014
Surface chemistry plays an important role in gold nanoparticles(AuNPs) stability and biocompatibility, which are crucial for their successful implementation into the clinical setting. We evaluated short-(30min) and long-term(28days) biodistribution and toxicity of ~20nm citrate- and pentapeptide CALNN-coated AuNPs after a single intravenous injection (~0.7mg Au/Kg) in rats. The pattern of ...
Stoetzer Marcus M Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany. Electronic address: - - 2014
Subperiosteal preparation using a periosteal elevator leads to disturbances of local periosteal microcirculation. Soft-tissue damage can usually be considerably reduced using piezoelectric technology. For this reason, we investigated the effects of a novel piezoelectric device on local periosteal microcirculation and compared this approach with the conventional preparation of the periosteum ...
Fontes-Pereira A A Programa de Engenharia Biomédica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
A simple experimental protocol applying a quantitative ultrasound (QUS) pulse-echo technique was used to measure the acoustic parameters of healthy femoral diaphyses of Wistar rats in vivo. Five quantitative parameters [apparent integrated backscatter (AIB), frequency slope of apparent backscatter (FSAB), time slope of apparent backscatter (TSAB), integrated reflection coefficient (IRC), ...
Acewicz Albert A Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, - - 2014
Anxiety, depression, and alcohol use disorders often go together. The aim of the present study was to evaluate anxiety- and depressive-like traits in selectively bred Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats. Alcohol-naïve WHP rats were more active in the open field test as compared to alcohol-naïve ...
Oliveira Marcos Aurélio Barboza de MA Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, - - 2014
Introduction: Solutions that cause elective cardiac arrest are constantly evolving, but the ideal compound has not yet been found. The authors compare a new cardioplegic solution with histidine-tryptophan-glutamate (Group 2) and other one with histidine-tryptophan-cetoglutarate (Group 1) in a model of isolated rat heart. Objective: To quantify the fractal dimension ...
Mahoney Amanda A - - 2014
Because the location of landmines is initially unknown, it is impossible to arrange differential reinforcement for accurate detection of landmines by pouched rats working on actual minefields. Therefore, provision must be made for maintenance of accurate responses by an alternative reinforcement strategy. The present experiment evaluated a procedure in which ...
Vongerichten Anna A 1] Department of Medical Physics and Bioengineering, University College London, London, UK. [2] Department of Neurosurgery, National Hospital of Neurology and Neurosurgery, London, - - 2014
Endotracheal intubation of rats is a common technique that is best carried out with a laryngoscope blade. The blade allows direct visualization of the trachea during intubation, reducing the risk of accidental intubation of the esophagus. Laryngoscope blades for use in rats are not commercially available, however. Three-dimensional (3D) printers ...
Wolf A A Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center and Saarland University Faculty of Medicine, Building 57, D-66421 Homburg, - - 2014
Rats are commonly used in medical research as they enable a high grade of standardization. The exhalome of ventilated rats has not as yet been investigated using an ion mobility spectrometer coupled with a multi-capillary column (MCC-IMS). As a first step, a rat model has to be established to measure ...
Dyr Wanda W Department of Pharmacology and Physiology of the Nervous System, Institute Psychiatry and Neurology, Warszawa, Poland. Electronic address: - - 2014
Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats ...
Eto Tomoo T Central Institute for Experimental Animals, Kawasaki 210-0821, Japan. Electronic address: - - 2014
The present study was performed to develop a suitable cryoprotectant solution for cryopreservation of rat two-cell stage embryos. First, we examined the cell permeability of several cryoprotectants; propylene glycol had the fastest permeability compared to dimethyl sulfoxide, ethylene glycol, and glycerol. Embryos were then exposed to a solution containing propylene ...
Naugler Willscott E WE Dept. of Medicine, Division of GI & Hepatology, Oregon Health & Science Center, Portland, Oregon, United States of America; Oregon Stem Cell Center, Oregon Health & Science Center, Portland, Oregon, United States of - - 2014
Many signals governing liver regeneration (LR) following 2/3 partial hepatectomy (PH) are recognized, but the primary signal(s) remains unknown. The aim of the study was to confirm that the remnant liver after PH lacks capacity to secrete the BA pool returning via the enterohepatic ciruculation (EHC), which may in turn ...
- - 2014
[This corrects the article on p. 4077 in vol. 8, PMID: 24204138.].
Ji Yun Y Department of Natural Medicinal Chemistry, China Pharmaceutical University , Nanjing, Jiangsu Province , P.R. China - - 2013
Abstract Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application. The aim of this paper was to explore sodium cholate (NaCh) as a potential solvent for Hyp and assess the targetability of (131)I-Hyp in rat necrosis models. Hyp ...
Yan Jin - - 2013
Myclobutanil, (RS)-2-(4-chlorophenyl)-2-(1H-1, 2, 4-triazol-1-ylmethyl)hexanenitrile is a broad-spectrum systemic triazole fungicide which consists of a pair of enantiomers. The stereoselective degradation of myclobutanil was investigated in rat liver microsomes. The concentrations of myclobutanil enantiomers were determined by high-performance liquid chromatography (HPLC) with a cellulose-tris-(3,5-dimethyl-phenylcarbamate)-based chiral stationary phase (CDMPC-CSP) under reversed phase ...
Yoshida Toshiaki T Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. Electronic address: - - 2014
The urinary excretion kinetics of a fluorine-containing pyrethroid transfluthrin [(2,3,5,6-tetrafluorophenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate], which is widely used recently as mosquito repellents, was examined in rats to search for urinary metabolites suitable as biomarkers for monitoring transfluthrin exposure of the general population. After a single dose of 26, 64, 160 or 400mg/kg body ...
Shukla Ravi S - - 2013
In our previous study, we have identified a PCBP2 siRNA that exhibits antifibrotic activity in rat hepatic stellate cells (HSCs) by inhibition of αCP2, a protein responsible for stabilization of the collagen α1 (I) mRNA in alcoholic liver fibrosis. This study aims to develop a streptavidin-based nanocomplex that can efficiently ...
Sullins Veronica F VF Department of Surgery, Division of Pediatric Surgery, University of California, Los Angeles, Los Angeles, CA 90095-1749, - - 2014
Previous studies demonstrated successful mechanical lengthening of rat jejunum using an encapsulated Nitinol spring device over a stabilizing guidewire. We sought to improve the applicability of intestinal lengthening by creating a biodegradable device. Using properties of the Nitinol spring device, polycaprolactone (PCL) springs with similar outer diameter and spring constant ...
Smit Henk - - 2013
To evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE-IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla. The recently published mCINE-IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations ...
Wlodzimirow K A - - 2013
The aim of this study was to assess the classification accuracy of an e-Nose in detecting acute liver failure (ALF) in rats. Exhaled breath from 14 rats was repeatedly sampled by e-Nose (8 sensors) and an additional external CO2 sensor at three stages: healthy period; portacaval shunt; and during the ...
Lim Kwang Su - - 2013
A series of carbonate analogues of 5'-halogenated RTX have been investigated in order to examine the effect of the carbonate group as a linker and the role of halogens in the reversal of activity from agonism to antagonism for rat and human TRPV1 heterologously expressed in Chinese hamster ovary cells. ...
Yan Wenyi - - 2013
A truncated conical beam model is developed to study the vibration behaviour of a rat whisker. Translational and rotational springs are introduced to better represent the constraint conditions at the base of the whiskers in a living rat. Dimensional analysis shows that the natural frequency of a truncated conical beam ...
Torrent Elia - - 2013
AbstractThe goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [11C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two ...
Perez Isaac O IO Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, - - 2013
Despite decades of study, it remains a matter of controversy as to whether in rats taste identification is a rapid process that occurs in about 250-600 ms (one to three licks) or a slow process that evolves over seconds. To address this issue, we trained rats to perform a taste-cued ...
Jiang Sheng-Dan SD Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2013
The pathogenesis of osteoporosis after spinal cord injury (SCI) may be different from disuse osteoporosis. To investigate whether there is the differential anabolic response to mechanical loading between osteoblasts from SCI rats and those from hindlimb-immobilized rats. Femoral bone-marrow was harvested for osteoblast culture from SCI rats, hindlimb-immobilized rats, and ...
Yoshida Shinya S Division of Rehabilitation, Kanazawa University - - 2013
[Purpose] This study was performed to investigate the histological changes that occur in the periphery of the sciatic nerve in rats undergoing knee immobilization. [Subjects and Methods] 29 male 9-week-old Wistar rats were divided randomly into a control group (C group, n = 7) and an immobilized group (I group, ...
Palygin Oleg O Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
Extracellular nucleotides such as adenosine-5'-triphosphate (ATP) and reactive oxygen species are essential local signaling molecules in the kidney. However, measurements of changes in the interstitial concentrations of these substances in response to various stimuli remain hindered due to limitations of existing experimental techniques. The goal of this study was to ...
Su Cheng-Kuan - - 2013
Although the unique optical properties of surface-modified quantum dots (QDs) have attracted wide interest in molecular biology and bioengineering, there are very few reports of their in vivo biodistribution, due to a lack of analytical techniques for characterizing the dynamic variation of QDs in living animals. In this study, we ...
Yang Tao - - 2013
Andrographolide (AND), one of the major diterpenoids from Andrographis paniculata (Burm. f.) Nees, can be metabolized as a phase two metabolite of 14-deoxy-12-hydroxy-andrographolide-19-O-β-d-glucuronide in human. The aim of this study is to characterize and synthesize the phase one metabolite of 14-deoxy-12-hydroxy-andrographolide (DEO-AND) after gavage feeding of AND in rats, and ...
Liu Hongling - - 2013
Background: Cell-based therapies for liver disease rely on a high quality supply of hepatocytes and a means for storage during transportation from site of isolation to site of usage. Unfortunately, frozen cryopreservation is associated with unacceptable loss of hepatocyte viability after thawing. The purpose of this study was to optimize ...
Oliveira Tiago R - - 2013
Despite positive efficacy, thermotherapy is not widely used in clinical oncology. Difficulties associated with field penetration and controlling power deposition patterns in heterogeneous tissue have limited its use for heating deep in the body. Heat generation using iron-oxide super-paramagnetic nanoparticles excited with magnetic fields has been demonstrated to overcome some ...
Dai Ming-Zhi - - 2013
We successfully demonstrate the first solid-state sensor to have reliable responses to breath ammonia of rat. For thioacetamide (TAA)-induced hepatopathy rats, we observe that the proposed sensor can detect liver that undergoes acute-moderate hepatopathy with a p-value less than 0.05. The proposed sensor is an organic diode with vertical nanojunctions ...
Min Yong - - 2013
To examine the effect of the posture of immobilization upon the tensile properties in injured Achilles tendon of rat for an initial period of immobilization. Forty-two Sprague-Dawley rats were used in the present study. Eighteen rats received a total tenotomy of the right Achilles tendon to mimic total rupture and ...
Jang Shih-Fan - - 2013
To investigate the relationship between particle size and gastric emptying in rodents using radiolabeled insoluble polymethyl methacrylate (PMMA) microcapsules/beads. PMMA microcapsules (50-500 µm) and beads (0.5-3 mm) loaded with technetium-99 m diethylenetriamine pentaacetic acid ((99m) Tc-DTPA) were administered to ICR mice or Sprague Dawley (SD) rats by oral gavage. Gamma scintiscans were acquired ...
Gupta Girish K - - 2013
Aim: A layer-by-layer matrix (LBL) comprising kaempferol (LBL-KEM) was prepared for improved osteogenic action. Materials & methods: The LBL-KEM consisted of alternate layers of sodium alginate and protamine sulfate, which were sequentially deposited on the preformed kaempferol (KEM)-loaded CaCO(3) core (CaCO(3)-KEM) by LBL self-assembly. The LBL matrix developed was evaluated ...
Yang Jie - - 2013
Ilex hainanensis Merr. is commonly used as a folk remedy for treating hypertension, dyslipidemia and inflammation in Traditional Chinese Medicine (TCMs) and it also has great potential to treat non-alcoholic fatty liver disease (NAFLD). Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A are three major bioactive components in I. hainanensis extract. In ...
Reinagel Pamela P Section of Neurobiology, Division of Biological Sciences, University of California at San Diego La Jolla, CA, - - 2013
The trade-off between speed and accuracy of sensory discrimination has most often been studied using sensory stimuli that evolve over time, such as random dot motion discrimination tasks. We previously reported that when rats perform motion discrimination, correct trials have longer reaction times than errors, accuracy increases with reaction time, ...
Wang Xianqin - - 2013
Hydrogen sulfide (H2S) is one of the neurotoxic gases with suffocating and irritating. Its main target organs of toxic effects are the central nervous system and respiratory system. Cocktail method was used to evaluate the influence of chronic hydrogen sulfide poisoning on the activities of cytochrome P450 (CYP450) isoforms CYP1A2, ...
Teloh Johanna K - - 2013
[This corrects the article on p. e72848 in vol. 8.].
Baptista Igor L - - 2013
In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome system and the PI3K/Akt pathway during two distinct atrophic conditions, hindlimb immobilization and dexamethasone treatment. Leucine supplementation was able to minimize the reduction in rat soleus mass driven by ...
Ivanov A N - - 2012
We studied the effects of irradiation with teraherz electromagnetic waves at frequencies corresponding to nitric oxide emission and absorption molecular spectrum (150,176-150,664 GHz) on activity of the sympathoadrenal and pituitary-adrenal axes of the stress response in albino male rats under conditions of acute immobilization stress. It was shown that terahertz ...
Song Xiao - - 2012
The aim of this work was to study the in situ and in vivo nasal absorption of borneol. A novel single pass in situ nasal perfusion technique was applied to examine the rate and extent of nasal absorption of borneol by rats. Experimental conditions, such as perfusion rate, pH and ...
Grigor'eva M V - - 2012
In narcotized rats, verapamil and cinnarizine modified some heart rate variability (HRV) indices and heart rate (HR) indicating up-regulation of parasympathetic tone in contrast to nifedipine that elevated activity of sympathetic subdivision of ANS producing no influence on HR. In wakeful stressed rats, the time-domain and geometric analysis established that ...
Lekshmi Unnikrishnan Meenakshi Dhana - - 2012
Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue. Therefore, there is a pressing need for careful consideration of benefits and side ...
Li Min - - 2012
Enkephalinergic neurons in the rostral ventrolateral medulla (rVLM), an important presympathetic region in the brainstem, are activated by 30 min of low frequency (2 Hz) electroacupuncture (EA) at acupoints P5-P6, which overlie the median nerves. To more closely model the clinical application of acupuncture, we administered EA for 30 min ...
Lokesh Deb - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: The present investigation was aimed to justify the pharmacological basis in traditional use of Clerodendrum colebrookianum as antihypertensive agent in North-East India. MATERIALS AND METHODS: The aqueous extract (AECc), its aqueous, n-butanol (nBFCc), Ethyl-acetate (EtFCc) and Chloroform fractions of C. colebrookianum leaves were evaluated for antihypertensive potential by ...
Hong Zhanying - - 2012
A rapid high-performance liquid chromatographic method was developed and validated for determination of tetrahydropalmatine (THP), an active component of Rhizoma Corydalis, in rat plasma. The samples were prepared using protein precipitation and separated on an Agilent XDB-C(18) column (150 × 4.6 mm, 5 µm) with the mobile phase consisting of ...
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