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Chamizo V D VD Facultat de Psicologia, Institute for Brain, Cognition and Behavior (IR3C), Departament de Psicologia Bàsica, Universitat de Barcelona, Passeig de la Vall d'Hebron, 171, 08035, Barcelona, Spain, - - 2014
In Experiment 1, two groups of female rats were trained in a triangular pool to find a hidden platform whose location was defined in terms of a single a landmark, a cylinder outside the pool. For one group, the landmark had only a single pattern (i.e., it looked the same ...
Fang Weirong W State Key Laboratory of Natural Medicines, Department of Physiology, China Pharmaceutical University, Nanjing, 210009, People's Republic of - - 2014
Following ischemic stroke, blood-brain barrier (BBB) is disrupted and is further aggravated with the corresponding incidence of hyperlipidemia. BBB breakdown promotes inflammation infiltration into the brain, which exacerbates cerebral ischemic injury as a result. Here, we report that 10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H), a novel analog of ginkgolide B, alleviates BBB ...
Sergutina A V AV Department of Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia, - - 2014
Acetylcholinesterase activity was quantitatively evaluated by cytochemical method in brain structures (layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, hippocampus CA3 field) of August and Wistar rats demonstrating high and low motor activity in the open fi eld test. In August rats, acetylcholinesterase activity in the ...
Du Lai-Ling LL Key Laboratory of Neurological Diseases of Education Ministry, Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. - - 2014
Collecting evidence has shown that type 2 diabetes mellitus is a high risk factor of late-onset Alzheimer's disease (AD); the energy metabolic dysfunction is thought to be a convergent point of the two diseases. However, the underlying mechanisms of diabetes-associated AD are still unclear. In the current study, we investigated ...
Ke Xingrao X Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, - - 2014
Intrauterine growth restriction (IUGR) programs neurodevelopmental impairment and long-term neurological morbidities. Neurological morbidities in IUGR infants are correlated with changes hippocampal volume. We previously demonstrated that IUGR alters hippocampal cellular composition in both neonatal and juvenile rat pups in association with altered hippocampal gene expression and epigenetic determinants. PPARγ signaling ...
Vrajová Monika M Prague Psychiatric Center, Ustavni 91, 181 03, Prague 8, Czech Republic, - - 2014
There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N-methyl-D-aspartate receptors (NMDA) are affected by MA-induced glutamate release, we assessed the expression of ...
Liu Chan-Min CM School of Life Science, Jiangsu Normal University, No.101, Shanghai Road, Tangshan New Area, 221116, Xuzhou City, Jiangsu Province, PR China. Electronic address: - - 2014
Proanthocyanidins (PCs), a class of naturally occurring flavonoids, had been reported to possess a variety of biological activities, including anti-oxidant, anti-tumor and anti-inflammatory. In this study, we examined the protective effect of PCs against lead-induced inflammatory response in the rat brain and explored the potential mechanism of its action. The ...
Petrosyan Tigran T ASIPE , Yerevan , - - 2014
Abstract Training induces plastic changes within the normal and injured brain. Experiments were performed on 48 albino rats. Part of the experimental animals were initially trained to a balancing instrumental conditioned reflex (ICR). Unilateral bulbar pyramidotomy performed in all rats caused contralateral hemiparesis. To make the study results more reliable, ...
Dunkerson Jacob J The Brain Research Laboratory, Saginaw Valley State University, University Center, MI, - - 2014
Purpose: Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPSC) have been shown to survive transplantation and ...
Patel Ryan R University College London, Gower Street, Department of Neuroscience, Physiology and Pharmacology, London, WC1E 6BT, UK. Electronic address: - - 2014
Menthol has historically been used topically to alleviate various pain conditions. At low concentrations, this non-selective TRPM8 agonist elicits a cooling sensation, however higher concentrations result in cold hyperalgesia in normal subjects and paradoxically analgesia in neuropathic patients. Through behavioural and electrophysiological means, we examined whether this back-translated into a ...
Kawaguchi Akira T AT Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, - - 2014
Liposome-encapsulated hemoglobin with low O2 -affinity (l-LEH) was shown to be protective in focal brain ischemia and reperfusion (I/R) in rats and primates. We tested l-LEH in the transient whole brain ischemia in the Tokai high-avoider rat (THA), which has been selected, mated, and bred over 77 generations for a ...
Chang Stephen E SE Johns Hopkins University, Psychological & Brain Sciences, 3400N. Charles Street, Baltimore, MD, 21218. Electronic address: - - 2014
A cue associated with a rewarding event can trigger behavior towards the cue itself due to the cue acquiring incentive value through its pairing with the rewarding outcome (i.e., sign-tracking). For example, rats will approach, press, and attempt to "consume" a retractable lever conditioned stimulus (CS) that signals delivery of ...
Takano Tomoyuki T Department of Pediatrics, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan - - 2014
To investigate seizure susceptibility in polymicrogyria, the seizure threshold and growth-associated protein GAP43 expression were analyzed in a rat experimental model of polymicrogyria induced by intracerebral injection of ibotenate. A total of 72 neonates from 9 pregnant rats were used. Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in ...
Fuchs Holger H Boehringer Ingelheim Pharma GmbH & Co. KG; - - 2014
Transporter gene knockout rat models are attracting increasing interest for mechanistic studies of new drugs as transporter substrates or inhibitors in vivo. However, limited data are available on the functional validity of such models at the blood-brain barrier. Therefore, the present study evaluated Mdr1a (P-gp), Bcrp and combined Mdr1a/Bcrp knockout ...
Khatib S S Department of Oxidative Stress and Human Diseases, MIGAL - Galilee Research Institute, Kiryat Shmona 11016, Israel; Tel-Hai College, Upper Galilee 12210, - - 2014
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron depletion. Early detection of PD may help in selecting the appropriate treatment. Biomarkers of PD have been suggested, however none of these is currently in clinical use. The aim of this study was to identify volatile organic compounds (VOCs) as early ...
Lee Ting-I TI Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of General Medicine, College of Medicine, Taipei Medical University, Taipei, - - 2014
High free fatty acid with reduced glucose utilization in diabetes mellitus (DM) impairs cardiac function. Peroxisome proliferator-activated receptors (PPARs) modulate myocardial lipid and glucose homeostasis. The active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates oxidative stress and inflammation, which may play a key role in the modulation of PPARs. The aim of this ...
Taridi Nursiati Mohamad NM Department of Biochemistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, - - 2014
Little is known about the effect of vitamin E on brain function. Therefore, in this study we evaluated the effect of tocotrienol rich fraction (TRF) on behavioral impairment and oxidative stress in aged rats. Thirty-six male Wistar rats (young: 3-months-old; aged: 21-months-old) were treated with either the control (olive oil) ...
Yang Huiyun H School of Biomedical Engineering, Tianjin Medical University, - - 2014
Purpose: The present study clarified the effects of repetitive transcranial magnetic stimulation (rTMS) in rats with vascular dementia (VaD) and explored the underlying mechanisms. Methods: Two-vessel occlusion was used as a VaD model. Two weeks after carotid artery occlusion, high (5 Hz) or low (1 Hz) frequency rTMS were applied ...
Zhou Hong-Yu - - 2014
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and type 2 (11β-HSD2) are expressed in rat testis, where they regulate the local concentrations of glucocorticoids. Here, we investigated the expression and localization of 11β-HSD in rat testis during postnatal development, and the regulation of these genes by luteinizing hormone (LH) and androgens. mRNA ...
Ding Dalian D Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China, - - 2014
Prior studies have demonstrated that the inner ear can accumulate a variety of essential and potentially toxic heavy metals including manganese, lead, cobalt and cadmium. Metal accumulation is regulated in part by the functionality and affinity of these metals for the different transport systems responsible for uptake across the blood-cochlea ...
Carnevali Luca L Stress Physiology Laboratory, Department of Neuroscience, University of Parma, 43124 Parma, - - 2014
Respiratory patterns represent a promising physiological index for assessing emotional states in preclinical studies. Since disturbed emotional regulation may lead to forms of excessive aggressiveness, in this study we investigated the hypothesis that rats that differ largely in their level of aggressive behavior display matching alterations in respiration. Respiration was ...
Lee Minkyung M Department of Nuclear Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, Republic of - - 2014
The purpose of the present study is to investigate the relationship between dopaminergic neuron destruction and 5-HT system changes in a hemiparkinsonian rat model. We performed PET imaging studies with trans-[(18)F]Mefway in a hemiparkinsonian model of unilateral 6-hydroxydopamine (6-OHDA) rats. Region-of-interests (ROIs) were drawn in the hippocampus (HP) and cerebellum ...
Walker Matthew D MD Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, - - 2014
Background: A major risk-factor for developing Parkinson's disease (PD) is genetic variability in leucine-rich repeat kinase 2 (LRRK2), most notably the p.G2019S mutation. Examination of the effects of this mutation is necessary to determine the etiology of PD and to guide therapeutic development. Objective: Assess the behavioral consequences of LRRK2 ...
Cheng Pei-Wen PW Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, - - 2014
Insulin-like growth factor-1 (IGF-1) is abundantly expressed in the nucleus tractus solitarii (NTS). In a previous study, we revealed that the induction of nitric oxide (NO) production in the NTS reduces blood pressure (BP). It is well known that both acute and chronic administration of IGF-I reduce BP. The aim ...
Laursen Bettina B H. Lundbeck A/S, Synaptic Transmission 1, Valby, Denmark Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, - - 2014
P300 (P3) event-related potentials (ERPs) have been suggested to be an endogenous marker of cognitive function and auditory oddball paradigms are frequently used to evaluate P3 ERPs in clinical settings. Deficits in P3 amplitude and latency reflect some of the neurological dysfunctions related to several psychiatric and neurological diseases, e.g., ...
Ji Xiao-Wei XW Department of Neurology, Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. - - 2014
The aim of the present study was to investigate the changes in the levels of serotonin (5-HT), dopamine (DA), norepinephrine (NE) and fibroblast growth factor-2 (FGF-2) in the brains of rats with post-stroke depression (PSD). A rat model of stroke was established by middle cerebral artery occlusion and the rats ...
Astikainen Piia P Department of Psychology, University of Jyväskylä, Jyväskylä, - - 2014
It is not known whether animals can, similarly to humans, categorize auditory objects based on an abstract rule in combining their physical features. We recorded local-field potentials from the dura above the primary auditory cortex in urethane-anesthetized rats presented with sound series occasionally violating a rule (e.g., "the higher the ...
Koba Satoshi S Division of Integrative Physiology, Tottori University Faculty of Medicine - - 2014
Sympathoexcitation elicited by central command, a parallel activation of the motor and autonomic neural circuits in the brain, has been shown to become exaggerated in chronic heart failure (CHF). The present study tested the hypotheses that oxidative stress in the medulla of CHF plays a role in exaggerating central command-elicited ...
Newson Penny N PN School of Biomedical Sciences and Pharmacy, University of Newcastle, NSW 2308, Australia; Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, - - 2014
Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Previously it was shown that rats treated on day 2 of life with capsaicin had behavioural hyperactivity in a novel environment at 5-7 weeks of age ...
Tolkacheva Eg E University of Minnesota, Biomedical Engineering, Minneapolis, United States of - - 2014
Intermittent vagal nerve stimulation (VNS) has recently been shown to reduce arrhythmia in animals and humans with chronic heart failure (CHF). The electrophysiological changes underpinning these benefits remain largely uncharacterized. Therefore, we aimed to investigate the electrophysiological remodeling resulting from long-term intermittent VNS therapy in the CHF rat. Myocardial infarction ...
Kong Wei-Na WN The 3rd Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei Province, People's Republic of - - 2014
Studies have shown that men and women exhibit significant differences regarding iron status. However, the effects of sex on iron accumulation and distribution are not well established. In this study, female and male Sprague-Dawley rats were killed at 4 months of age. Blood samples were analyzed to determine the red blood ...
Weiss Omri O Department of Zoology, Tel-Aviv University, 69978, Ramat-Aviv, Tel-Aviv, - - 2014
When animals explore an unfamiliar environment, they gather information that enables them to form a cognitive representation of that environment and to use it subsequently in traveling there. In the present study, rats were tested in a large arena as singles, then in dyads, and finally, again as singles, in ...
Shi Cui-Ge CG a Department of Cell Biology , National Research Institute of Family Planning , Beijing 100081 , - - 2014
Tanshinol (3-(3',4'-dihydroxyphenyl)-(2R)-lactic acid, TSL) is widely used in traditional Chinese medicine for the treatment of cardiovascular and cerebrovascular diseases. Here, we assessed whether TSL protected hippocampus and attenuated vascular dementia (VD) development in rats. The behavioral analysis showed that TSL could decrease the distance and latency time, and increase the ...
Zell Vivien V Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 5 rue Blaise Pascal, F-67084 Strasbourg, France; Laboratory of Neurophysiology and Psychobiology, University of Luxembourg, 162A, avenue de la Faïencerie, L-1511 - - 2014
Nociceptive processing is tuned by GABAA receptor-mediated inhibition in the spinal cord dorsal horn that undergoes postnatal maturation in rodents. These GABAergic inhibitory postsynaptic currents (IPSCs) are modulated by 3α5α-reduced steroids during early postnatal development in spinal cord lamina II. Thus an enhanced phasic inhibition is present in neonates and ...
Dave Kuldip D KD The Michael J. Fox Foundation for Parkinson's Research. 498 Seventh Avenue, 18th Floor, New York, NY 10018. Electronic address: - - 2014
Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset Parkinson's disease (PD). As part of its strategy to provide more tools for the research community, The Michael J. Fox Foundation for Parkinson's Research (MJFF) funded the ...
Sanna Fabrizio F Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, and Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, Monserrato, Cagliari, Italy. Electronic address: - - 2014
Outbred Roman High- (RHA) and Low-Avoidance (RLA) rats, originally selected for rapid vs. poor acquisition of active avoidance in a shuttle box, show differential copulatory patterns when exposed to a receptive female. Indeed, in the first copulation test male RHA rats show more mounts, intromissions and ejaculations than RLA rats. ...
Defazio Rossella R Aptuit Safety Assessment, Verona, Italy - - 2014
Brain trimming through defined neuroanatomical landmarks is recommended to obtain consistent sections in rat toxicity studies. In this article, we describe a matrix-guided trimming protocol that uses channels to reproduce coronal levels of anatomical landmarks. Both setup phase and validation study were performed on Han Wistar male rats (Crl:WI(Han)), 10-week-old, ...
Kasacka Irena I Department of Histology and Cytophysiology, Medical University, 15-222 Bialystok, Poland - - 2014
Taking into consideration the homeostatic disorders resulting from renal hypertension and the essential role of cocaine- and amphetamine-regulated transcript (CART) in maintaining homeostasis by regulating many functions of the body, the question arises as to what extent the renovascular hypertension affects the morphology and dynamics of changes of CART-containing cells ...
Basurto-Islas Gustavo G Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, - - 2014
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). In this model, viral expression of the phosphoprotein phosphatase 2A (PP2A) endogenous inhibitor, the I2(PP2A), or SET protein in the brains of rats leads to several characteristic features of AD ...
Sreenivasa Reddy S S Biochemistry Division, National Institute of Nutrition, Hyderabad, - - 2014
Obesity is associated with various progressive age-related diseases, including neurological disorders. However, underlying molecular basis for increased risk of neurodegeneration in obesity is unknown. A suitable animal model would immensely help in understanding the obesity-linked neurological problems. A spontaneously developed obese rat (WNIN/Ob) which is highly vulnerable for a variety ...
Luo Hao H Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, - - 2014
Exposure to high-pressure blast shock waves is known to cause tinnitus. Although the underlying mechanisms may involve damage to structures in the ear and/or direct brain impact, which triggers a cascade of neuroplastic changes in both auditory and nonauditory centers, it remains unclear how the induced neuroplasticity manifests neurophysiologically. This ...
Miura Hirohito H Department of Oral Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. Electronic address: - - 2014
The effects of aging on the umami sensation were compared between the preference and neural responses from the greater superficial petrosal nerve (GSP innervating the soft palate) and the chorda tympani nerve (CT innervating the fungiform papillae) in the Sprague Dawley rat. A two-bottle preference test revealed that younger rats ...
Tarhouni Kahena K University of - - 2014
In resistance arteries a chronic increase in blood flow induces hypertrophic outward remodeling. This flow-mediated remodeling (FMR) is absent in male rats aged 10 months and more. As FMR depends on estrogens in 3-month old female rats, we hypothesized that it might be preserved in 12-month old female rats. Blood ...
Wang Desheng D Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, 26506; Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, WV, - - 2014
Patch clamp recordings of neurons in the adult rat deep cerebellar nuclei have been limited by the availability of viable brain slices. Using a new slicing technique, this study was designed to explore the maturation of membrane properties of neurons in the deep cerebellar nuclei (DCN), -an area involved in ...
Wang Ling L Department of Ophthalmology, Ruijin Hospital, Medicine School of Shanghai, Jiaotong University, Shanghai, China; Department of Clinical Sciences, Ophthalmology, Umeå University, Umeå, - - 2014
Developmental characteristics of the neuronal adaptive system of the retina, focusing on background light (BGL) adaptation and readaptation functions, were studied by measuring the oscillatory response (SOP) of the electroretinogram (ERG). Digitally filtered and conventional ERGs were simultaneously recorded. Rats aged 15 and 17 days were studied during exposure to BGLs ...
Dong Ping P Department of Anesthesiology, Qilu Hospital, Shandong University, No.44 Wenhua Xi Road, Jinan City, Shandong Province, 250012 - - 2014
Aging is associated with exacerbated brain injury after ischemic stroke. Herein, we explored the possible mechanisms underlying the age-associated exacerbated brain injury after ischemic stroke and determined whether therapeutic intervention with anesthetic post-conditioning would provide neuroprotection in aged rats. Male Fisher 344 rats (young, 4 months; aged, 24 months) underwent ...
Steiner Adam P AP Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, - - 2014
Disappointment entails the recognition that one did not get the value expected. In contrast, regret entails recognition that an alternative (counterfactual) action would have produced a more valued outcome. In humans, the orbitofrontal cortex is active during expressions of regret, and humans with damage to the orbitofrontal cortex do not ...
Liu Zengxun Z aDepartment of Psychiatry, Shandong University School of Medicine bDepartment of Psychiatry, Shandong Mental Health Center, Jinan, - - 2014
Abuse of methamphetamine (MA) increases the risk of infection of HIV-1, induces considerable neurotoxicity in several brain regions, and impairs the motor and cognitive function in individuals. HIV-1 transactivator of transcription (Tat) has also shown the potent capability to induce neuronal death and impaired brain function. The present study aims ...
Wiley Jenny L JL Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298-0613, USA. Electronic address: - - 2014
Mechanisms that may underlie age and sex differences in the pharmacological effects of cannabinoids are relatively unexplored. The purpose of the present study was to determine whether sex differences in metabolism of Δ(9)-tetrahydrocannabinol (THC), similar to those observed previously in adult rats, also occurred in adolescent rats and might contribute ...
Gururajan Anand A Behavioral Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, - - 2014
Brain-derived neurotrophic factor (BDNF)has key roles in neurodevelopment and synaptic plasticity and is implicated in affective disorders such as anxiety and depression. The aim of the present study was to use BDNF heterozygous mutant rats (HET) and wildtype controls (WT) to investigate the effect of BDNF downregulation on affective behaviors. ...
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