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Liu Jiaming - - 2014
A novel knot method in rats is reported that addresses several drawbacks in the current model of aortic constriction-induced heart hypertrophy. Using a rat model, we developed a two-step procedure that includes: 1) measurement of individual aorta circumference using a surgical thread; and 2) constriction of the aorta using a ...
Jin Long-Hu LH Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, - - 2014
The aim of this study was to apply a new surgical procedure that allows for the successful monitoring of intraurethral pressure (IUP) changes in the cystometry of awake Sprague-Dawley rats. Twenty-six female Sprague-Dawley rats were grouped according to the catheterization method (bladder only; bladder and urethra; or bladder, urethra, and ...
Yamada Kazuo K Institute of Psychology and Behavioral Neuroscience, University of Tsukuba, Tsukuba, Ibaraki, 305-8577, Japan, - - 2014
"Retrieval-induced forgetting" in rats was evaluated using a modified spontaneous object recognition test. The test consisted of a sample phase, retrieval or interference phase, and a test phase with 60-min delay period inserted between the phases. Rats were randomly assigned to one of three groups (control, retrieval and interference) and ...
Yu Jin J 0000-0003-2049-3677 Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China ; Traditional Chinese Medicine University of Shanghai, Shanghai 201203, - - 2014
Objective. To explore the effect of Cryptotanshinone on reversing the reproductive and metabolic disturbances in polycystic ovary syndrome (PCOS) model rats and the possible regulatory mechanisms. Methods. PCOS model rats were induced by subcutaneous injection of dehydroepiandrosterone (DHEA) and verified by histological screening of vaginal exfoliated cells. After Cryptotanshinone intervention, ...
Yan-Yan Jia - - 2013
C. sappan is a medicinal plant native to China popularly used to treat chronic pelvic inflammation, dysmenorrhea and hysteromyoma. Its main bioactive component is brazilin which had presented antibacterial, anti-inflammatory and anti-platelet aggregation activities. To establish a sensitive, selective, reproducible, and accurate high performance liquid chromatographic (HPLC) method for the ...
Stryjek Rafał - - 2013
One of the challenges associated with breeding and testing of wild animals in the laboratory is their drive to escape. Wild rats attempt to escape their cages as soon as they are opened, and recapturing is often difficult and dangerous to laboratory personnel. The authors describe a method of recapturing ...
Muñoz-Velasco Israel I Laboratorio de Microscopía Electrónica, Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, - - 2013
Seminiferous tubules in mammals have histological arrangements defined by the associations between somatic cells and germ cells. The processes of DNA synthesis in meiotic and mitotic cells have different features that are not easily distinguishable through morphological means. In order to characterize the pre-meiotic S phase, 5-bromo-2'-deoxyuridine (BrdU) was injected ...
Akbulut Sevtap - - 2013
OBJECTIVES: Everolimus is an immunosuppressant and an antiproliferative macrolide agent which is used for coronary stent coating for local inhibition of in-stent restenosis. The aim of this study was to evaluate the effect of everolimus-coated tympanostomy tubes in rat tympanic membrane. STUDY DESIGN: Prospective controlled animal study. MATERIALS AND METHODS: ...
Bhutada Sumit - - 2013
The present study identifies uterine fluid proteins which display differential abundance, during the embryo-permissive phase in non-conception and conception cycles in rats. Uterine fluid (UF) samples were collected from nonpregnant rats in the proestrous (n=17) and metestrous (n=18) phases; and also from pregnant (n=17) and pseudopregnant (n=17) rats on the ...
Feng Su-Xiang - - 2012
A comparative oral pharmacokinetic study of five anthraquinones (aloe-emodin, emodin, rhein, chrysophanol and physcion) from the extract of Rheum palmatum L. was performed in normal and thrombotic focal cerebral ischemia (TFCI)-induced rats. The plasma samples were clarified through solid phase extraction prior to simultaneous determination of the anthraquinones with a ...
Jin H - - 2012
Variations among inbred rats in terms of anatomy and routine laboratory values can potentially blur surgical experimental results. Therefore, a retrospective analysis aiming at investigating hepatic and perihepatic anatomical variations, liver weight, body weight, liver weight/body weight ratio (LBWR), variations in routine laboratory values, and the influence of shipment and ...
Zotz T G G TG Escola Politécnica, Programa de Pós Graduação em Tecnologia em Saúde, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil. - - 2012
Heterotopic ossification (HO) is a metaplastic biological process in which there is newly formed bone in soft tissues adjacent to large joints, resulting in joint mobility deficit. In order to determine which treatment techniques are more appropriate for such condition, experimental models of induced heterotopic bone formation have been proposed ...
Nirogi Ramakrishna - - 2012
In the present study, we investigated the performance of adult and juvenile rats in the Object Recognition Task (ORT). While it is well known that the performance of rat in ORT differs with age, the reason for the difference as well as the underlying neurotransmitter that may have led to ...
Soares M J MJ Institute for Reproductive Health and Regenerative Medicine, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. - - 2012
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the ...
Tanaka Yusuke - - 2012
The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated the regional differences in these factors in the rat GI tract. The solubility of griseofulvin, a poorly water-soluble drug, in the ...
Otani Lila - - 2011
The analytical method was optimized for L-cysteine (Cys) in rat plasma with co-existing L-cystine (Cyss). We observed that more than 100% Cyss in rat plasma was converted to Cys under typical conditions for the conversion with 7-fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F). Another conversion reagent, 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole (ABD-F), was then employed, with which the reaction ...
Karamouzian Saeid - - 2011
An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat. To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat. Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease ...
Jing Liu - - 2011
In this study, we analyzed causes of abdominal hemorrhage after reduced-size liver transplantation in rat. Healthy SD rats (weight range of 260-280 g) underwent liver transplantation, the donors were female and the recipients were male rats. The recipients were, on average, by <10 g heavier than the donors. All operations on donor ...
Aydın Keramettin - - 2011
Estimation of the cell number after cortical venous ischemia/infarction induced by anterior and posterior anastomotic veins occlusion in a rat model is very important. Twenty male Sprague-Dawley rats were used in this experiment. Small burr-holes were made over the anterior (the crossing point of the line drawn from the posterior ...
Xu Keping K Departments of Ophthalmology, Wayne State University School of Medicine, Detroit, - - 2011
PURPOSE. The purpose of the study was to investigate the effects of hyperglycemia on EGFR (epidermal growth factor receptor)-mediated wound response and signal transduction in the corneal epithelium of rats with type I diabetes mellitus (DM). METHODS. Corneal epithelia were removed from streptozotocin (STZ)- and weight-matched normal rats. Wound healing ...
Wang Li-Shu - - 2011
The present study used a postinitiation protocol to investigate molecular mechanisms by which black raspberries (BRBs) influence the late stages of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in rats. F344 rats were injected with NMBA and then fed either control diet or a diet containing 5% BRB powder. Control rats were injected ...
Yamada Tetsuji - - 2011
To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regions of ...
Li M - - 2011
The immunological consequences of cryoablation for gliomas are largely unknown. cryoablation is an attractive therapeutic option for tumors due to its minimally invasive nature. cryoablation is also potentially immunogenic. With an aim to explore changes in cellular immunity following argon-helium cryosurgery, we established Wistar rat models bearing subcutaneous C6 glioma ...
Liu Jing - - 2010
Danggui-Shaoyao-San (DSS), a traditional Chinese medicinal prescription, is clinically used for the treatment of vascular dementia (VD). This study compared the pharmacokinetics of paeoniflorin, the main active ingredients in Paeonia lactiflora Pall, in VD and normal rats administrated with DSS or pure paeoniflorin. The absorptions of paeoniflorin in both VD ...
Mutti Elena - - 2010
We investigated the effect of cobalamin (Cbl) deficiency on epidermal growth factor receptor (EGFR) mRNA levels in the spinal cord (SC) and liver of rats made Cbl-deficient (Cbl-D) by means of total gastrectomy or a Cbl-D diet, and simultaneously measured the levels of the epidermal growth factor (EGF). Both methods ...
Ehlert Angelika - - 2010
Research using rats sometimes requires long-term placement of catheters in the subarachnoid space, the cavity between the arachnoid mater and the pia mater in the brain. These catheters can be used to experimentally induce subarachnoid bleeding by injecting blood or to locally administer drugs or other substances. To date, published ...
Tan Sonny Kh - - 2010
DEEP BRAIN STIMULATION (DBS) as a therapy in neurological and psychiatric disorders is widely applied in the field of functional and stereotactic neurosurgery. In this respect, experimental DBS in animal models is performed to evaluate new indications and new technology. In this article, we review our experience with the concept ...
Spieles-Engemann A L - - 2010
In this review we outline some relevant considerations with regards to the rat model of deep brain stimulation of the subthalamic nucleus (STN DBS). In order to optimize the rat STN DBS model in terms of predictive validity for the clinical situation we propose that the STN stimulation experimental design ...
Govindaraj Jayamathi - - 2010
The role of proanthocyanidins (PC), a novel flavonoid extracted from grape seeds was studied in vitro in the modulation of neutrophil and macrophage function. We attempted to assess the levels of non-enzymatic and enzymatic mediators in the presence or absence of PC in 4-phorbol-12-beta-myristate-13-acetate (PMA)-stimulated neutrophils isolated from humans and ...
Pádua Bruno da Cruz Bda - - 2010
ETHNOPHARMACOLOGICAL RELEVANCE: Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. AIM OF THE STUDY: The aim ...
Sabirov A G - - 2010
We carried out a detailed analysis of rat model of esophageal achalasia previously developed by us. Manifest morphological and functional disorders were observed in experimental achalasia: hyperplasia of the squamous epithelium, reduced number of nerve fibers, excessive growth of fibrous connective tissue in the esophageal wall, high contractile activity of ...
Całkosiński I - - 2010
The objective of the study was to determine interval values of biochemical parameters in the most commonly applied experimental model among different species, i.e. rats. Blood analysis of experimental animals is done in different research fields. They are important especially in experiments in pharmacology, pathophysiology, experimental surgery, toxicology and for ...
Tanriover Gamze - - 2010
OBJECTIVE: To assess the distribution of cerebral cavernous malformation-2 (CCM2) and CCM3 proteins in a normal and experimentally induced varicocele model in rat testes. DESIGN: Comparative and controlled study. SETTING: University animal care and operation unit. ANIMAL(S): Wistar male rats for experimental and control groups. INTERVENTION(S): The control group underwent ...
Donia Marco - - 2009
We have presently evaluated the effects of the immunomodulatory drug rapamycin on the course of protracted relapsing experimental allergic encephalomyelitis (PR-EAE) in Dark Agouti (DA) rats, which serves as a preclinical model of multiple sclerosis. The data show that the oral administration of rapamycin at 3 mg/kg for 28 consecutive ...
Jiao Kai - - 2009
OBJECTIVE: To investigate the effect of experimentally created disordered occlusion (ECDO) on cell death and proliferation in rat mandibular condylar cartilage. METHODS: Sprague-Dawley rats were randomly assigned to experimental and control groups. In the experimental groups, ECDO was created by the dental orthodontic method. By means of histological evaluation, immunohistochemistry ...
Soković M - - 2008
The in vivo evaluation of the toxicological and antifungal activity of the essential oil of Thymus vulgaris L. and its main component thymol was made on 2-month-old male Wistar rats. We examined the therapeutic potency against experimentally induced dermatomycoses in rats, using the most frequent dermatomycetes, Trichophyton mentagrophytes, T. rubrum, ...
Mironova V I - - 2008
Depressive state of Wistar rats in the model of learned helplessness was accompanied by a persistent increase in the expression of corticotropin-releasing factor in the hypothalamus. Vasopressin content in the hypothalamus was modified only in the early poststress period and remained unchanged at the late stage of experimental depression. Our ...
Ubiali Federica - - 2008
Pixantrone (BBR2778) (PIX) and mitoxantrone share the same mechanism of action because both drugs act as DNA intercalants and inhibitors of topoisomerase II. PIX is an interesting candidate immunosuppressant for the treatment of autoimmune diseases because of its reduced cardiotoxicity compared with mitoxantrone. The clinical response to conventional immunosuppressive treatments ...
Bulucu F - - 2007
The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. ...
Dimitrijević M - - 2007
As glucocorticoids influence both catecholamine synthesis and adrenoceptor expression by immune cells, the current study was undertaken to distinguish their direct effects on the development of experimental allergic encephalomyelitis from those induced by alteration of catecholamine signaling. We examined the influence of 16-day-long beta-adrenoceptor blockade with propranolol (0.40 mg/100 g ...
Polat Zubeyde Akin - - 2007
Amoebic keratitis, a sight-threatening, progressive corneal disease, is commonly caused by ubiquitous, pathogenic, free-living Acanthamoeba spp., which are widely distributed in the environment. We investigated clinical findings and histology of Acanthamoeba keratitis in a rat cornea model. Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba ...
Fijalkowski Ronald J - - 2007
A new experimental model was developed to induce diffuse brain injury (DBI) in rats through pure coronal plane angular acceleration. An impactor was propelled down a guide tube toward the lateral extension of the helmet fixture. Upon impactor-helmet contact, helmet and head were constrained to rotate in the coronal plane. ...
Abdurasulova I N - - 2007
We compared preventive and therapeutic effects of memantine, a selective blocker of NMDA-receptors, and IEM-1966, a blocker of both NMDA- and GluR1 AMPA-receptors, on the model of acute experimental allergic encephalomyelitis. Memantine in high doses prevented the development of experimental allergic encephalomyelitis only in 10% rats, slightly (by 1.4-1.5 times) ...
Lazarov Simeon - - 2007
Pulmonary complications often accompany the development of acute peritonitis. In this study, we analyzed the alterations of alveolar surfactant phospholipids in rats with experimentally induced peritonitis. The results showed a reduction of almost all phospholipid fractions in pulmonary surfactant of experimental animals. The most abundant alveolar phospholipids-phosphatidylcholine and phosphatidylglycerol were ...
Hasegawa Takeshi - - 2007
A long-time issue that thin films supported on a substrate with low refractive index cannot be subjected to multiple-angle incidence resolution spectrometry (MAIRS) has been resolved, and an advanced MAIRS technique has been developed. Infrared multiple-angle incidence resolution spectroscopy (IR MAIRS) is being recognized as a powerful spectroscopic tool for ...
Sel'kov S A - - 2007
Intraperitoneal injection of rat IFN-alpha and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted in a significant reduction of proliferative activity of its cells, degree of vascularization, and number of macrophages in ...
Sagara Nina - - 2007
The association between the use of statins and age-related macular degeneration (AMD), a leading cause of blindness, has been evaluated in many clinical studies; however, the results have been contradictory. We evaluated the effect of pitavastatin administration on laser-induced experimental choroidal neovascularization (CNV) in rats. Brown Norway rats received pitavastatin ...
Srivastava Amit Kumar - - 2007
To develop a simple experimental model for cerebral venous sinus thrombosis in rat, 24 male Sprague-Dawley rats (14 experimental and 10 controls) were studied. After anesthesia, a 1.5 mm x 10 mm cranial window was made to expose superior sagittal sinus (SSS). A filter paper strip soaked in 40% ferric ...
Sims, Natalie Ann
Three leaves of erratum inserted inside front cover.
Aytan Hakan - - 2007
The effect of immunomodulator leflunomide on the development of an experimental endometriosis model was assessed by surgically transplanting autologous fragments of endometrial tissue onto the inner surface of the abdominal wall and arterial cascades of the small intestines. Leflunomide was found to affect the development of endometriosis negatively and seemed ...
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