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Yamamoto-Fukuda Tomomi T Department of Histology and Cell - - 2014
Abstract Conclusion: We demonstrated that repression of keratinocyte growth factor (KGF) receptor (KGFR) could be a potentially useful strategy in the conservative treatment of middle ear cholesteatoma. Recently, the use of a selective inhibitor of the KGFR, SU5402, in an in vitro experiment resulted in the inhibition of the differentiation ...
Shan Hu H Department of Cardiology, The Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, 157 Xiwu Road, Xi'an, 710004, Shaanxi, - - 2014
Calreticulin (CRT) is a calcium-buffering protein which is predominantly located in endoplasmic reticulum. In the previous mitochondria proteome analysis, we accidentally found that CRT may be also localized at myocardial mitochondria and was upregulated in a rat model of furazolidone-induced dilated cardiomyopathy. To our knowledge, there has not yet been ...
Zhang Yan Y School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, - - 2014
Tribbles are a family of signal-regulating proteins shown to coordinate the action and the suppression of different pathways. Tribbles homolog 3 (Trib3), the best-studied member of the mammalian tribble family, has a key function in determining cell fate when responding to environmental challenges. Trib3 effects are also modulated by its ...
Ho Ming-Chih MC Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, - - 2014
We investigated the feasibility of using 3-D ultrasound Nakagami imaging to detect the early stages of liver fibrosis in rats. Fibrosis was induced in livers of rats (n = 60) by intraperitoneal injection of 0.5% dimethylnitrosamine (DMN). Group 1 was the control group, and rats in groups 2-6 received DMN injections for ...
Chilingaryan Amaiak A 1 Department of Biology, Occidental College, 1600 Campus Road, Los Angeles, CA 90041, - - 2014
Currently there are no methods available for staining rat and human myocardial microvasculature on thick sections that would allow for specific staining and differentiation of arterioles, venules, and capillaries. A non-injection technique is described that allows for labeling of the microvascular bed (MVB) in formalin-fixed pieces of the myocardium from ...
Gilibili Ravindranath Reddy RR Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada V6T - - 2014
There is a growing body of evidence that exposure to endocrine disrupting chemicals and to estrogenic compounds in particular can affect the testis and male fertility. In the present study, the constitutive expression of steroidogenic and non-steroidogenic cytochrome P450 (CYP) and related enzymes in adult rat testis, and their regulation ...
Zhao Shiyu S Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, - - 2014
Superparamagnetic iron oxide magnetic nanomaterials (SPIO) are tracers used for treatment of central nervous and cardiovascular system complications in animal models. The present study investigated survival and proliferation of SPIO-labeled bone marrow mesenchymal stem cells (BMSCs) to determine their potential therapeutic value in liver repair. Surface antigens of BMSCs were ...
Zhang Ping P Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. - - 2014
The aim of the present study was to provide a simple method of establishing a rat model for focal cerebral ischemia-reperfusion (FCIR). The suture-occluded method was used to establish FCIR in male Sprague-Dawley rats. An incision was made over the bifurcation of the common carotid artery (CCA), through which a ...
Kangas L L Hormos Medical Ltd., Pharmacity, Turku, - - 2014
Ospemifene is a tissue-selective estrogen agonist/antagonist that was recently approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy, which occurs in up to approximately 50% of postmenopausal women. The current analyses were conducted to determine whether ospemifene exhibits estrogenic activity in the mammary glands of ovariectomized rats ...
Zhang Yongli Y Department of Endocrinology, Affiliated Hospital of Yanan University, No. 43 North Street, 716000 Yanan, - - 2014
Calcitonin is usually produced by the parafollicular cells of the thyroid. However in an immunohistochemistry experiment we observed that the cells of the serous acini of rat submaxillary gland tissue were stained positive with calcitonin antibodies. We further used immunocytochemistry and nucleic acid hybridization to localize the distribution of calcitonin ...
Banzato Tommaso T Department of Animal Medicine, Production and Health, University of Padua, Viale dell'Università 16, 35020 Legnaro, Padua, - - 2014
Objective-To determine ultrasonographic features and reference values of the anatomy of the abdomen of common rats (Rattus norvegicus). Animals-20 adult male and 20 adult female rats. Procedures-A complete abdominal ultrasonographic examination was performed with the rats sedated. The cadavers of 4 rats were used for anatomic comparisons. Two cadavers were ...
Yang Fan F Department of Urology, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, - - 2014
Patients undergoing radical prostatectomy (RP) are at high risk for erectile dysfunction (ED) due to potential cavernous nerve (CN) damage during surgery. Penile hypoxia after RP is thought to significantly contribute to ED pathogenesis. We previously showed that corpora cavernosum smooth muscle cells (CCSMCs) undergo phenotypic modulation under hypoxic conditions ...
Bonnard Asa - - 2013
Abstract Conclusion: No nuclear progesterone receptors were found in human or rat stria vascularis, organ of Corti or spiral ganglion with immunohistochemistry or polymerase chain reaction (PCR). Progesterone receptor B (PR-B) was found with Western blot in the cochlea, probably representing the staining in the cochlear bone. The effect of ...
Fisher Elaine M EM School of Nursing, The University of Akron, Akron, OH, 44325, USA, - - 2013
We noninvasively monitored the partial pressure of oxygen (pO2) in rat's small intestine using a model of chronic mesenteric ischemia by electron paramagnetic resonance oximetry over a 7-day period. The particulate probe lithium octa-n-butoxynaphthalocyanine (LiNc-BuO) was embedded into the oxygen permeable material polydimethyl siloxane by cast-molding and polymerization (Oxy-Chip). A ...
Misiakiewicz Kamila - - 2013
The aim of the study was to investigate the effects of pharmacologically induced hormonal imbalance in adult male rats treated with letrozole and rats exposed to soya isoflavones on the testicular morphology and c-Kit receptor (c-Kit-R) expression in germ cells. The study was conducted during all developmental periods: prenatal period, ...
Ortiz Mario I - - 2013
There is evidence that biguanides and sulfonylureas block diclofenac-induced antinociception (DIA) in rat models. However, little is known about the interaction between these hypoglycemics with respect to DIA. To determine whether metformin-sulfonylurea combinations affect DIA during the formalin test. Rats received the appropriate vehicle or diclofenac before 1% formaldehyde was ...
Xu Tao - - 2013
Endogenous estrogen deficiency usually causes the systemic osteoporosis including the jaw bones. However, it remains unclear whether estrogen deficiency can affect the tooth mineralization. In this study, the classical osteoporotic rat model was established via the ovariectomy, which was subsequently confirmed by the detection of serum estradiol levels and body ...
Tseng Yuan-Yun - - 2013
Aim: We developed biodegradable, lidocaine-embedded poly([D,L]-lactide-co-glycolide) nanofibers for epidural analgesia to reduce the severe pain in rats after laminectomies. Materials & methods: Nanofibers were prepared by an electrospinning process and were introduced into the epidural space of rats after laminectomy. The lidocaine concentration, postoperative bodyweight change and amount of food/water ...
Banik Ratan K RK Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA. - - 2013
This study describes a modified Hargreaves' method for assessing paw withdrawal threshold temperatures for heat (PWT-H) nociception in the hind paws of rats. This method utilises radiant heat to maintain controlled lamp temperatures (CLTs) on a glass floor beneath the rat hind paw. An ascending series of CLTs were applied ...
Gioviale M C - - 2013
Marginal donors represent a poorly utilized source of organs for transplantation despite their availability. The key is to reduce the ischemic damage in the effort to improve organ quality. This study investigated the histologic effects after in situ perfusion of preservation with a two-layer method compared with the classic University ...
DeMorrow Sharon S Research, Central Texas Veterans Health Care System, Temple, TX 76504, - - 2013
Neuropeptide Y (NPY) exerts its functions through six subtypes of receptors (Y₁-Y₆). Biliary homeostasis is regulated by several factors through autocrine/paracrine signaling. NPY inhibits cholangiocarcinoma growth; however, no information exists regarding the autocrine/paracrine role of NPY on biliary hyperplasia during cholestasis. The aims of this study were to determine: 1) ...
Picut Catherine A - - 2013
In response to growing concerns that environmental chemicals may have adverse effects on human health by altering the endocrine system, the Endocrine Disruptor Screening Program (EDSP), under the auspices of the United States Environmental Protection Agency (U.S. EPA), recently instituted a Tier I battery of tests including a female pubertal ...
El-Salhy Magdy - - 2013
Endoscopy is an important tool in the diagnosis, follow-up and management of several gastrointestinal diseases. In experimental studies, the course and progression of gastrointestinal lesions are followed by sacrificing animals at specific time intervals and the disease is usually assessed postmortem. This approach has several disadvantages, including the requirement of ...
Yamamoto-Silva Fernanda P - - 2013
The aim of the present research was to analyze ultrastructural and immunohistochemical aspects of the alveolar repair after the extraction of molars of alendronate (ALN)-treated rats. Wistar rats received 2.5mg/kg body wt/day of ALN during 14 days previously and 7, 14 and 21 days after the extraction of the second ...
Nishijima Kazutoshi - - 2013
Follicular populations were investigated in female F344/N rats to better understand the aging process of the rat ovary. Ovaries dissected at various ages (spanning 1-36 months old) were submitted for histological examination. The total number of primordial, growing (primary and secondary), tertiary, and atretic follicles as well as corpora lutea ...
Zhou Birong - - 2013
Fibrinogen (Fg) contributes to thrombosis and hemostasis and plays a role in inflammation. Fg is also known to play a significant role in atherosclerosis (AS). P-selectin has been associated with AS. The present study aimed to identify the role of Fg in AS and to examine the possible mechanisms behind ...
Araújo Tiago G - - 2013
A simple, easy, and safe procedure aiming to improve liver regeneration could be of great clinical benefit in critical situations such as major hepatectomy, trauma, or hemorrhage. Low-power laser irradiation (LPLI) has come into a wide range of use in clinical practice by inducing regeneration in healthy and injured tissues. ...
Masszi Gabriella G Cardiology Unit, Bajcsy-Zsilinszky Hospital, Budapest, Hungary. - - 2013
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism and insulin resistance, both of which have been connected to atherosclerosis. Indeed, an increased risk of clinical manifestations of arterial vascular diseases has been described in PCOS. On the other hand endothelial dysfunction can be detected early on, ...
Wang Xiaoyu - - 2013
Previous studies demonstrated that primo vessels (PVs) were distributed in different parts of the body in mammals, and PVs were also involved in some processes of pathology such as cancer. Whether PVs are intrinsic structures in mammals or not is still ignored. In this study, a peritonitis model rat was ...
Mohsen Setayesh M - - 2013
Plastination is a new method of preserving tissue samples for a long time. This study aimed to compare the new plastination technique with the conventional preservative method in glycerin for fetus skeleton tissues and young rats dyed by Alizarin red- Alcian blue double staining. In this study, 4 groups of ...
Ozdemir Ozgur - - 2012
The aim of this study was the investigation of effects of the metenolone enanthate (ME) that is used among athletes as doping and muscle amplifier, on hearts of male and female rats that are in puberty using morphometrical methods. A total of 36 rats which were divided into three separate ...
Bilen Sule - - 2012
OBJECTIVE: We aimed to investigate the effects of bone marrow derived mesenchymal stem cells (MSCs), minocycline, and these two therapies combined on functional and histological improvement in cerebral ischemic injury created rats. MATERIALS AND METHODS: Twenty-eight Sprague Dawley female rats, weighing 250-300 g, were included in the study. Two male rats ...
Gomi Hiroshi H Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, Kanagawa, Japan. - - 2013
Islet-associated protein-2 (IA-2) and IA-2β (also known as phogrin) are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs). The IA-2 family of PTPs was originally identified from insulinoma cells and discovered to be major autoantigens in type 1 diabetes. Despite its expression in the neural and canonical endocrine tissues, data on expression ...
Chen Xiao-Wu - - 2012
There are only few reports about the use of bone marrow stromal stem cells (BMSCs) for the treatment of traumatic liver injury. This study aimed to study the therapeutic effect of fluorescence-labeled BMSCs administered to rats subject to traumatic liver injury. Male SD rats with a 70% resection of the ...
Haange Sven-Bastiaan - - 2012
The digestion of food ingredients depends on the action of the gut microbiota and has a significant influence on the health, especially in case of metabolic diseases of the host organism. Despite the relevance of the structure and functionalities in the microbiota for the metabolism of the host the spatial ...
Su Chieh-Shou - - 2012
CONTEXT: Tracheal intubation of anaesthetised rats for laboratory experiments remains an essential yet challenging procedure. OBJECTIVE: We aimed to investigate whether tracheal intubation can be safely and securely accomplished in laboratory rats employing only handy instruments and with minimal experience. DESIGN: The feasibility and safety of a modified orotracheal intubation ...
Li Guang-Yong - - 2012
OBJECTIVE: To investigate the injected autologous adipose-derived stem cells (ADSCs) in improving stress urinary incontinence in a rodent model of parturition-related stress incontinence and the possible mechanism. METHODS: The 40 rats were developed stress urinary incontinence models by postpartum balloon dilation of the vagina for 4 hours followed by bilateral ...
Wakabayashi Taketoshi - - 2012
During development of the nervous system, large numbers of neurons are overproduced and then eliminated by programmed cell death. Puma is a BH3-only protein that is reported to be involved in the initiation of developmental programmed cell death in rodent retinal neurons. The expression and cellular localization of Puma in ...
Adeniyi Temidayo - - 2012
In this study, the lateral geniculate bodies (LGB) of rats, bats and pangolins were compared using histological and quantitative histochemical parameters to observe possible modifications that enable these mammals to cope with their habitation particularly with respect to their diet. The study was conducted using ten adult Wistar rats, ten ...
Zheng Sushuang - - 2012
The rat is a powerful model for the study of human physiology and diseases, and is preferred by physiologists, neuroscientists and toxicologists. However, the lack of robust genetic modification tools has severely limited the generation of rat genetic models over the last two decades. In the last few years, several ...
Jena Srikanta - - 2012
In the present study effects of 6-n-propyl thiouracil (PTU)-induced hypothyroidism on renal antioxidant defence system during postnatal development (from birth to 7, 15 and 30days old) and on adult rats were reported. Hypothyroidism in rats was induced by feeding the lactating mothers (from the day of parturition till weaning, 25days ...
Wikramanayake T C TC Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, - - 2012
More than half of all people diagnosed with cancer receive chemotherapy, and approximately 65% of these develop chemotherapy-induced alopecia (CIA), a side-effect that can have considerable negative psychological repercussions. Currently, there are very few animal models available to study the mechanism and prevention of CIA. To develop a clinically relevant ...
Chen Li-Feng - - 2012
Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surgeons (RCS) rat retinas ...
Liu Shi-Bo - - 2012
Fibroblast growth factor 8 (FGF8) is an androgen-induced growth factor (AIGF) that is crucial for embryonic development. This study was developed to investigate the role of FGF8 in developmental abnormalities of the genital tubercle (GT) in hypospadiac male rats when prenatally exposed to di-n-butyl phthalate (DBP). DBP was administered to ...
Welchko Ryan M - - 2012
Parkinson's disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. Of the genes that have been linked to PD, α-synuclein and leucine-rich repeat kinase 2 have ...
Cantoria Mary Jo MJ School of Kinesiology and Nutritional Science, California State University, Los Angeles, California 90032-8162, - - 2011
After spinal cord transection, the generation of stepping depends on neurotransmitter systems entirely contained within the local lumbar spinal cord. Glutamate and glycine likely play important roles, but surprisingly little is known about how the content of these two key neurotransmitters changes to achieve weight-bearing stepping after spinal cord injury. ...
Hassan M H - - 2011
Uterine leiomyomas (fibroids) are the most common pelvic tumors in women. We assessed the potential therapeutic utility of Ro 41-0960, a synthetic catechol-O-methyl transferase inhibitor (COMTI), in the Eker rat. We randomized uterine fibroid-bearing Eker rats for treatment with Ro 41-0960 (150 mg/kg/12 h) versus vehicle for 2 and 4 ...
Hai-Gang Chen - - 2011
Objective To establish an appropriate animal model of uterine leiomyoma and to understand the pathogenesis of this disease. Methods Mature female rats were intramuscularly injected with estradiol benzoate at 200 μg or 300 μg twice a week. After injection for 8 or 10 weeks, the rats were sacrificed. We measured ...
Gong Yao - - 2011
OBJECTIVE(S): To establish an experimental bowel endometriosis model in the rat and to investigate regional lymph node involvement. STUDY DESIGN: Twenty Sprague-Dawley rats were subjected to autologous transplantation of endometrial tissue to the ileocecum by laparotomy. After two months, endometriotic lesions and mesenteric lymph nodes were harvested by repeat laparotomy ...
Sadar Miranda J - - 2011
Two unrelated rats were presented to the Western College of Veterinary Medicine emergency service for vaginal bleeding. Each was taken to surgery due to marked blood loss and suspicion of uterine pathology. Despite similar clinical presentation, gross and histopathologic examination revealed 2 different underlying disease processes, uterine dilatation with mild ...
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