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Söderlund Göran G Sogn og Fjordane University College, Sogndal, - - 2014
The spontaneously hypertensive (SH) rat model of ADHD displays impaired motor learning. We used this characteristic to study if the recently described acoustic noise benefit in learning in children with ADHD is also observed in the SH rat model. SH rats and a Wistar control strain were trained in skilled ...
Ghodbane Soumaya S Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Jarzouna, Tunisia. - - 2014
Static magnetic fields (SMFs) effect observed with radical pair recombination is one of the well-known mechanisms by which SMFs interact with biological systems. Our aim was to study whether SMF induces oxidative stress and apoptosis in rat tissues and to evaluate the possible protector effect of selenium (Se) and vitamin ...
Nagy David D Translational Neuropharmacology, Section of Comparative Medicine, Yale School of Medicine, New Haven, - - 2014
Several neurophysiological abnormalities have been described in Huntington's disease, including auditory gating deficit, which are considered to reflect impaired brain information-processing. Since transgenic animal models of Huntington's disease capture basic neuropathology of the disorder, auditory gating was studied in BACHD (line5) transgenic rats and Q175 transgenic mice, together with local ...
Türedi Sibel S Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University , Trabzon , Turkey - - 2014
Abstract The growing spread of mobile phone use is raising concerns about the effect on human health of the electromagnetic field (EMF) these devices emit. The purpose of this study was to investigate the effects on rat pup heart tissue of prenatal exposure to a 900 megahertz (MHz) EMF. For ...
Bhat Mehrajuddin M Department of Endocrinology & Metabolism, Hyderabad, - - 2014
The Vitamin D endocrine system is functional in the adipose tissue, as demonstrated in vitro, in cultured adipocytes, and in vivo in mutant mice that developed altered lipid metabolism and fat storage in the absence of either 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or the vitamin D receptor. The aim of the present ...
Gao Bei B Key Laboratory of Industrial Ecology and Environmental Engineering, MOE, School of Environmental Science and Technology, Dalian University of Technology, Dalian, - - 2014
Hair analysis is potentially advantageous in exposure assessment of perfluoroalkyl acids (PFAAs) as a non-invasive method, combined with the ability to reflect long-term exposure. The present study aims to assess the feasibility of using hair as an indicator of PFAA exposure. Adult male and female rats were subchronically exposed to ...
Nishimura Yoko Y Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561-0825, - - 2014
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for cardiotoxicity in rats. As organ specificity is an important factor ...
Attia Amalina Binte Ebrahim AB Institute of Bioengineering and Nanotechnology (IBN), 31 Biopolis Way, The Nanos, #04-10, 138669, - - 2014
Polymeric micelles with and without galactose are synthesized to study liver targeting ability in an orthotopic HCC rat model. Micelles with galactose accumulate more in the healthy liver tissue instead of HCC, while micelles without galactose amass in HCC by the EPR effect. These micelles show great potential as drug ...
Kim Hyun-Soo HS Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea ; Republic of Korea Air Force Aerospace Medical Center, Chungcheongbuk-do 363-849, Republic of - - 2014
The occurrence of idiopathic pulmonary lesions in laboratory rats, characterized by lymphohistiocytic interstitial pneumonia with dense perivascular lymphoid cuffs, has been reported over the past decade. Although the term rat respiratory virus (RRV) was adopted to confer a putative viral etiology to the idiopathic pulmonary lesions, the etiology of this ...
Pinaeva O G OG Far-Easter State Medical University, Vladivostok, Russia, - - 2014
We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia ...
Eichendorff Sascha S Department of Biomedicine, Aarhus University, Ole Worms Alle 3, Blng 1170, 8000, Aarhus, - - 2014
The hemoglobin scavenger receptor CD163 is exclusively expressed on monocytes and tissue macrophages, also at sites of inflammation. We examined whether gallium-68 (Ga-68)-labeled anti-CD163-antibody can detect the receptor in vivo. We radiolabeled anti-CD163 antibody with Ga-68 and evaluated stability and binding specificity of the conjugate ([(68)Ga]ED2) in vitro. Furthermore, tracer ...
Vettorazzi A A Departament of Pharmacology and Toxicology, University of Navarra Irunlarrea 1, 31080 Pamplona. Electronic address: - - 2014
Ochratoxin A (OTA) is a thermostable mycotoxin that contaminates a great variety of foodstuffs. It is nephrotoxic in all of the mammalian species tested, the pig being the most sensitive one; among rodents, rats are the most susceptible to OTA carcinogenicity. Kinetics, by studying the absorption, distribution, metabolism and excretion ...
Su Cheng-Kuan - - 2014
Whether silver nanoparticles (AgNPs) degrade and release silver ions (Ag+) in vivo has remained an unresolved issue. To evaluate the biodistribution and dissolution behavior of intravenously administered AgNPs in living rats, we employed a knotted reactor (KR) device to construct a differentiation scheme for quantitative assessment of residual AgNPs and ...
Miyazaki Kaoru K Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, - - 2014
Despite dramatic progress in infertility treatments and assisted reproduction, no effective therapies exist for complete loss of uterine structure and/or function. For such patients, genetic motherhood is possible only through gestational surrogacy or uterine transplantation. However, many ethical, social, technical and safety challenges accompany such approaches. A theoretical alternative is ...
Couturier Aline - - 2014
Activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPARdelta causes an elevation of tissue carnitine concentrations through induction of genes involved in carnitine uptake [novel organic cation transporter 2, (OCTN2)], and carnitine biosynthesis [gamma-butyrobetaine dioxygenase (BBD), 4-N-trimethyl-aminobutyraldehyde dehydrogenase (TMABA-DH)]. Recent studies showed that administration of the plasma lipid-lowering drug niacin causes ...
Xiong Xueyan X Laboratory of Oral Biomedical Science and Translational Medicine, Department of Orthodontics, School of Stomatology, Tongji University, Shanghai 200072, P.R. - - 2014
Hyposalivation is an intractable side‑effect of radiotherapy for head and neck cancer. It is caused by the irreversible loss of acinar cells and decreased saliva secretion. However, this situation severely compromises the quality of life of affected patients. Currently, there is no effective treatment for this condition. In the present ...
Zamparelli Alessandra A Department of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T) - Laboratory of Regenerative Morphology and Bioartificial Structures/S.Bi.Bi.T. Museum - Section of Human Anatomy, University of Parma, Parma, - - 2014
Few data are available on the effect of biomaterials on surface antigens of mammalian bone marrow-derived, adult mesenchymal stromal cells (MSCs). Since poly(L-lactic acid) or PLLA is largely used in tissue engineering of human bones, and we are developing a reverse engineering program to prototype with biomaterials the vascular architecture ...
Shanfei Ge G Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha, Hunan, - - 2014
Aim. Recent studies have suggested miRNA dysregulation in liver tissue mediates the pathogenesis of various liver diseases especially liver fibrosis, but the microRNA changes during PS-induced hepatic fibrosis are still unknown. The purpose of this study was to screen the miRNA differences in rat liver fibrosis model and clarify the ...
Leblanc Samuel S Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada (S.L., M.-C.B., C.N., N. G.-P., A.C.C., J.-P.B.); Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden (A.H.); Alberta Institute for Human Nutrition, Metabolic and Cardiovascular Disease Laboratory, University of Alberta, Edmonton, AB, Canada (D.F.V.); and Centre de recherche Étienne-Lebel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada (N. G.-P., A.C.C., - - 2014
Polycystic ovary syndrome (PCOS) is mainly defined by hyperandrogenism, but is also characterized by insulin resistance (IR). Studies showed that overexposure of non-adipose tissues to non-esterified fatty acids (NEFA) may explain both IR and hyperandrogenism. Recent studies indicate that treatment with an angiotensin II type 2 receptor (AT2R) selective agonist ...
Wang Boyi B Department of Cardiovascular Diseases, Affiliated Hospital, Luzhou Medical College, Luzhou, - - 2014
To investigate the expression of sphingosine 1-phosphate 1-3 (S1P1-3) on penile cavernous tissues in hypertensive and normotensive rats and its association with erectile function. Ten 14-week-old male spontaneously hypertensive rats (SHRs) and 10 male age-matched normotensive Wistar-Kyoto rats were randomly designated as hypertensive rat group and normotensive control group, respectively. ...
He Jiake - - 2014
A novel positron emission tomography (PET) tracer, [11C]-rosuvastatin (RSV), was developed to dynamically and non-invasively measure hepatobiliary transport and tissue distribution of [11C]- RSV in rats. Methods: Male Sprague-Dawley rats were administered either an Oatp inhibitor, rifampin (RIF, 40 mg/kg iv bolus plus 1.85mg/min/kg iv infusion, n=3), or the corresponding ...
Huang Ping P College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR - - 2014
Ascending and descending theory is a core principle of traditional Chinese medicine (TCM) theories. It plays an essential role in TCM clinical applications. Some TCM medicine has specific properties, which could alter the inclination and direction of their actions. The properties of the ascending and floating of one herbal medicine ...
Santi A A Departamento de Química, Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, - - 2014
The objective of the present study was to evaluate the effect of quercetin on oxidative stress biomarkers in methimazole (MMI) - induced hypothyroidism male rats. Hypothyroidism was induced by administering MMI at 20 mg/100 ml in the drinking water, for 1 month. After achieved hypothyroidism, rats received orally 10 or 25 mg/kg of ...
Xu Xiao Bing XB Department of Otorhinolaryngology, EYE and ENT Hospital of Fudan University, - - 2014
The aim of this study was to investigate the association between laryngeal expression of claudin-3 and laryngopharyngeal reflux (LPR) in a rat reflux model. Eight Wistar rats were divided into two groups. Four rats underwent total esophageal myectomy to induce reflux, and the remainder underwent a sham operation as a ...
Tan Libo L Pennsylvania State University, United - - 2014
Little is known about the contribution of different tissues to whole-body vitamin A (VA) kinetics in neonates. Here, we have used model-based compartmental analysis of tissue tracer kinetic data from unsupplemented (control) and VA-retinoic acid (VARA)-supplemented neonatal rats to determine VA kinetics in specific tissues under control and supplemented conditions. ...
Stratmann Greg G Department of Anesthesia and Perioperative Care, University of California San Francisco. Associate, Group Anesthesia Services, Los Gatos, - - 2014
Anesthesia in infancy impairs performance in recognition memory tasks in mammalian animals, but it is unknown if this occurs in humans. Successful recognition can be based on stimulus familiarity or recollection of event details. Several brain structures involved in recollection are affected by anesthesia-induced neurodegeneration in animals. Therefore, we hypothesized ...
Pimentel Camila Bianco CB - - 2014
Cryosurgery is an efficient therapeutic technique used to treat benign and malignant cutaneous diseases. The primary active mechanism of cryosurgery is related to vascular effects on treated tissue. After a cryosurgical procedure, exuberant granulation tissue is formed at the injection site, probably as a result of angiogenic stimulation of the ...
Aydogan Ahmet A a Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University , Burdur , - - 2014
Background: Bisphosphonates (BPs) like zoledronic acid (ZOL) are widely used for the treatment of different diseases such as osteoporosis, metastatic bone diseases and hypercalcaemia. However, the effects of BPs on apoptosis of the liver and kidney after treatment are unclear. Furthermore, basic fibroblast growth factor (bFGF) is an angiogenic molecule, ...
Jimenéz-Aranda Aroa A Deparment of Pharmacology and Neurosciences Institute, School of Medicine, University of Granada, Granada, - - 2014
Mitochondrial dysfunction in adipose tissue may contribute to obesity-related metabolic derangements such as type 2 diabetes mellitus (T2DM). Because mitochondria are a target for melatonin action, the goal of present study was to investigate the effects of melatonin on mitochondrial function in white (WAT) and beige inguinal adipose tissue of ...
Wang Zengtao - - 2014
In spite of the relatively high success rate of limb replantation, many patients cannot undergo replantation surgery because the preservation time of an amputated limb is only about six hours. In addition, although allotransplantation of composite tissues is being performed more commonly with increasingly greater success rates, the shortage of ...
Liu Pei P Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, - - 2014
Xiang-Fu-Si-Wu Decoction (XFSWD) has been widely used to treat primary dysmenorrhea in clinical practice for hundreds of years and shown great efficacy. One fraction of XFSWD, which was an elution product by macroporous adsorption resin from aqueous extract solution with 60% ethanol (XFSWE), showed great analgesic effect. The present study ...
Unsal Funda F Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, - - 2014
Ghrelin is a hormone which has effects on the secretion of growth hormone, the gastrointestinal system, the cardiovascular system, cell proliferation and the reproductive system. The aim of this study is to investigate structural changes in the uterine tissue and to assess ghrelin immunoreactivity in the endometrium as a result of bilateral ...
Jiang Hongbo H Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College of Chongqing University, Chongqing, - - 2014
Strain/stress induced tissue softening is usually referred to irreversible softening. The aim of this study was to investigate whether stress softening in rat esophagus is reversible after potassium chloride (KCl) induced contraction. Three series of inflation-deflation loadings were carried out on esophageal specimens obtained from 20 Wistar rats. All specimens ...
Kim Eun-Young EY Medical Device Development Center, Osong Medical Innovation Foundation, Chungbuk, - - 2014
Background and study aims: We evaluated the efficacy of small interfering RNA (siRNA) in targeting matrix metalloproteinase (MMP-9) to suppress stent-induced tissue hyperplasia in a rat esophageal model. Methods: The silencing effect of the candidate siRNA (termed (MMP-9 siRNA) was evaluated in 9 L rat glial cells. Four groups of rats ...
Catak Zekiye Z Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, - - 2014
Although, the exact mechanisms underlying the development of the metabolic syndrome (MetS) are not still completely understood, obesity, circulated peptide hormone levels and their interaction with genetic factors are considered largely responsible. The purpose of this study is to explore how the levels of ghrelin, obestatin (OBS) and NUCB2/nesfatin-1 (NES)/NUCB2 ...
Li Hao H Department of Cardiovascular Medicine, the First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. - - 2014
Perivascular adipose tissue (PVAT)-derived leptin is a detrimental adipocytokine and plays a critical role in the development of cardiovascular diseases in metabolic syndrome (MetS). During vascular remodeling, vascular smooth muscle cells (VSMCs) undergo phenotypic switching into a synthetic phenotype characterized by decreased expression of differentiation markers (smooth muscle myosin heavy ...
Zhang Weihua W Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, - - 2014
Large animal cardiopulmonary bypass (CPB) models are expensive, and prevent assessment of neurocognitive function, and difficulties with long-term recovery. The purpose of this study was to establish a novel rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest without blood priming. Twenty adult male Sprague-Dawley rats weighing 450-560 g ...
Yang Weijin W State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: - - 2014
There is large usage of polybrominated diphenyl ethers (PBDEs) especially for decabromodiphenyl ether (BDE-209, Deca-BDE) in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological ...
Hoffmann Guenther G 1Covance Laboratories, Inc., Madison, Wisconsin, - - 2014
A sporadic, diffuse, interstitial mixed cell epididymitis of unknown etiology was noted in the epididymal cauda and distal corpus of young control Sprague-Dawley (SD) rats. Rats from 2 different suppliers were examined as part of routine toxicology studies. The incidence of this finding was 5/5 (study 1), 2/7 (study 2), ...
Kato Yuki Y Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan ; Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Rinkuu Ourai Kita 1-58, Izumisano, Osaka 598-8531, - - 2014
The development of ectopic gastric, intestinal, or pancreatic tissue in the gastrointestinal tract is extremely rare in rats, although it is fairly common in humans. In this report, we describe an unusual case in which a mixture of different types of ectopic tissue was found in the forestomach of a ...
Siddiqi N J - - 2014
Gold nanoparticles have diverse applications and are being used in food and cosmetic industry, for drug delivery and in the diagnosis and treatment of cancer. However there is a need to study their biochemical mode of action. In this study, in vivo effect of gold nanoparticles on the activities of ...
Campbell Jerry L JL Center for Human Health Assessment, The Hamner Institutes for Health Sciences , Research Triangle Park, NC , - - 2014
Abstract A PBPK model for naphthalene in the rat and human that incorporates a hybrid CFD-PBPK description of the upper respiratory tract was developed to support cross-species dosimetry comparisons of naphthalene concentrations and tissue normalized rate of metabolism in the nasal respiratory and olfactory epithelium, lung and liver. In vitro ...
Paixão Mirian Dos Santos MD Department of Tropical Diseases, Botucatu School of Medicine - UNESP, Brazil. Electronic address: - - 2014
To elucidate the occurrence and epidemiology of leptospirosis in rats cohabitating with forest animals, 13 rats were captured at seven locations of the Centre for the Conservation of Wild Fauna (CCWF) in Sao Paulo state, Brazil, and samples of their blood, liver, and kidneys were collected. The diagnostic techniques utilized ...
Tang Bingwen B Department of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. - - 2014
The toxic effects caused by Kansui in liver and kidney were evaluated in detail through investigation of the systemic biochemical response of Kansui-treated rats, using an integrated metabonomic approach together with clinical biochemical and histopathological assessments. Detoxification of Kansui by vinegar processing of Kansui was also studied using these methods. ...
Zhou Xiang X Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, - - 2014
Accumulating evidence has demonstrated that hydrogen sulphide (H2 S) is involved in the pathogenesis of various respiratory diseases. In the present study, we established a rat model of passive smoking and investigated whether or not H2 S has protective effects against pulmonary fibrosis induced by chronic cigarette smoke exposure. Rat ...
Singh Smrita S Department of Ocular Pharmacology and Pharmacy, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New - - 2014
The present study was conducted to develop animal models to mimic postmenopausal/androgen deficiency dry eye and to evaluate the expression of sex steroid receptors (NR3A1, NR3A2 and NR3C4) in the ocular tissues of the developed models. Study was conducted in healthy Wistar rats of either sex weighing 180-250gms. Bilateral ovariectomy ...
Lavrinenko V A VA Novosibirsk National Research State University, Novosibirsk, Russia, - - 2014
We studied the effect of vasopressin V2 receptor agonist (desmopressin, 5 μg/100 g body weight for 2 days) on the efficiency of osmotic concentration in Wistar rats and homozygous Brattleboro rats defective by the synthesis of antidiuretic hormone. Specific differences in the reaction of the osmotic concentration system components (urine ...
Barbuto Rafael Calvao RC Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, - - 2014
Background : The use of alloplastic meshes has been historically contra-indicated in patients with infection. Aim : To evaluate the use of polypropylene meshes in the treatment of abdominal wall defects in rats with peritonitis. Methods : Twenty Wistar female rats were divided into two groups: induction of peritonitis (test ...
Pu Xiao-Yong XY Guangdong General Hospital, Guangdong Academy of Medical Science, Department of Reproductive Medicine, Guangzhou, Guangdong, China; Guangdong General Hospital, Guangdong Academy of Medical Science, Department of Urology, Guangzhou, Guangdong, China. Electronic address: - - 2014
The aim of this study is to investigate whether injection of short hairpin RNA (shRNA) constructs targeting IGFBP-3 in penis in old rat would improve erectile function. The most validated IGFBP-3 shRNA plasmid vector (pGPU6/GFP/Neo-sh IGFBP-3) was prepared and injected into the penile corpus cavernosum tissue. 30 old (24 months) ...
Osterberg E Charles EC Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, - - 2014
To determine if Raman spectroscopy (RS) can identify spermatogenesis in a Sertoli-cell-only (SCO) rat model. A partial SCO model was created using a testicular hypothermia-ischemia technique. Bilateral testis biopsy was performed on 4 rats. Raman spectra were acquired with a probe on 1mm(3) samples of testicular tissue. India ink was ...
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