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Ruan Zheng Z State Key Laboratory of Food Science and Technology, College of Life Science and Food Engineering, Nanchang University, Rm325, 235 Nanjing Street, Nanchang, 330047, - - 2014
Tryptophan (TRP) is an important precursor for several neurotransmitters and metabolic regulators, which play a vital role in regulating nutrient metabolism. The purpose of this study was to investigate the effects of tryptophan supplementation on the biochemical profiles, intestinal structure, liver structure and serum metabolome in rats. Rats received daily ...
Garcia Kristine L P KL Departments of Pharmacology and Toxicology & Psychiatry, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, - - 2014
Few studies investigate factors that influence acquisition in nicotine self-administration (NSA), such as food training and training dose. Most have utilized peak doses along nicotine's dose-response curve (15 and 30μg/kg) that establish NSA in the majority of animals. To investigate the specific and combined effects of training and dose on ...
Liu De-Jun DJ Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. - - 2014
Prostacyclin has been shown to increase portal hypertension, but the mechanism is unclear. This study aimed to investigate whether the overproduction of prostacyclin (PGI2) in cirrhosis participates in the splanchnic vascular hyporesponsiveness to vasoconstrictors in cirrhotic rats. Cirrhotic model was created by subcutaneous injection of 60% carbon tetrachloride (CCl4) corn ...
Kur'yanova E V EV Department of Human and Animal Physiology and Morphology, Astrakhan State University, Astrakhan, Russia, - - 2014
Changes in heart rhythm variability were studied in male and female mature and 5-6-week-old rats under conditions of 7-day administration of β1-adrenoreceptor blocker atenolol (2.5 mg/kg) and α1-adrenoreceptor agonist phenylephrine (0.3 mg/kg). Atenolol administration to mature rats was followed by a slight deceleration of cardiac rhythm, a tendency to heart ...
Kitamura Eiji E Department of Neurology, Kitasato University School of Medicine, Japan - - 2014
Obesity is a risk factor for episodic migraine to develop into chronic migraine; hence, it is speculated that obesity and hyperleptinemia are associated with migraine. We hypothesized that leptin is involved in the mechanisms of cortical spreading depression (CSD). Therefore, we examined whether leptin affected a rat model of CSD ...
Pavel Houdek H Department of Neurohumoral Regulations, Institute of Physiology, v.v.i., Academy of Science of the Czech Republic, Videnska 1083, 14220, Prague, Czech - - 2014
The mammalian circadian system develops gradually during ontogenesis, and after birth, the system is already set to a phase of the mothers. The role of maternal melatonin in the entrainment of fetal circadian clocks has been suggested, but direct evidence is lacking. In our study, intact or pinealectomized pregnant rats ...
Britten Richard A RA a  Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, Virginia - - 2014
Previous ground-based experiments have shown that cranial irradiation with mission relevant (20 cGy) doses of 1 GeV/nucleon (56)Fe particles leads to a significant impairment in Attentional Set Shifting (ATSET) performance, a measure of executive function, in juvenile Wistar rats. However, the use of head only radiation exposure and the biological ...
Sokanovic S J SJ Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, - - 2014
Here, we chronologically analyzed age-associated changes of cAMP- and MAPK-signaling in Leydig cells (LCs) in relation with decreased testosterone (T) production. In Wistar rats, decreased serum T observed in 12 to 24-month-old rats was not related to decreased serum LH concentration but to reduced luteinizing hormone receptor (Lhr/LHR) and time-coordinated ...
Lertsinthai Parinya P Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, - - 2014
In estrogen-deficient rodents with osteopenia, repetitive exposure to mild-to-moderate stress, which mimics the chronic aversive stimuli (CAS) of the modern urban lifestyle in postmenopausal women, has been hypothesized to cause the bone microstructure to further deteriorate. Recently, we have provided evidence in rats that voluntary impact exercise, e.g., wheel running, ...
Tapani Sofia S Fraunhofer-Chalmers Centre, Chalmers Science Park, Göteborg, Sweden; Discovery Statistics, Discovery Sciences, AstraZeneca R&D Mölndal, Mölndal, - - 2014
Data were pooled from several studies on nicotinic acid (NiAc) intervention of fatty acid turnover in normal Sprague-Dawley and obese Zucker rats in order to perform a joint PKPD of data from more than 100 normal Sprague-Dawley and obese Zucker rats, exposed to several administration routes and rates. To describe ...
Hemmati Ali Asghar AA Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ; Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, - - 2014
Application of vitamin K to the skin has been used for suppression of pigmentation and resolution of bruising. However, in rats, no study was reported on its effect regarding wound healing. Thus, the present study was designed to examine the healing effects of creams prepared from vitamin K1 on full-thickness ...
Zhuang Cheng-Le CL Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, 2 Fuxue Lane, Wenzhou 325000, Zhejiang Province, - - 2014
Ginsenoside Rb1 is reported to possess anti-fatigue activity, but the mechanisms remain unknown. The aim of this study was to investigate the molecular mechanisms responsible for the anti-fatigue effect of ginsenoside Rb1 on postoperative fatigue syndrome induced by major small intestinal resection (MSIR) in aged rat. Aged rats with MSIR ...
Trask Sydney S Department of Psychology, University of Vermont, Burlington, VT, 05405-0134, USA, - - 2014
Recent research has suggested that operant responses can be weakened when they are tested in new contexts. The present experiment was therefore designed to test whether animals can learn a context-(R-O) relation. Rats were given training sessions in context A, in which one response (R1; lever pressing or chain pulling) ...
Kirichuk V F VF V. I. Razumovskii Saratov State Medical University, Ministry of Health of the Russian Federation, Saratov, Russia, - - 2014
We studied the effect of terahertz waves (NO frequency range, 150.176-150.664 GHz) on stress-induced variations in behavioral reactions of male albino rats during hypokinetic stress. THz irradiation was followed by partial or complete normalization of behavioral reactions of male albino rats after hypokinetic stress. The most signifi cant effect was ...
Marriott Amber L AL Departments of Biomedical Sciences, University of Prince Edward Island, Charlottetown, - - 2014
Deficits in attention have long been identified as a core feature in schizophrenia and related neuropsychiatric disorders. We have investigated the combined effects of neonatal treatment with domoic acid (DOM) and social isolation rearing (both putative animal models of schizophrenia) on latent inhibition (LI), a measure of attentional processing. Daily ...
Thunhorst Robert L RL Department of Psychology, University of Iowa, Iowa City, IA 52242-1407; Department of Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407. Electronic address: - - 2014
The F344xBN strain is the first generational cross between Fischer 344 (F344) and Brown Norway (BN) rats. The F344xBN strain is widely used in aging studies as it is regarded as a model of "healthy" aging (Sprott, 1991). In the present work, male F344xBN rats aged 4 mo (young, n=6) ...
Beauval J B JB UROsphere, Faculty of Pharmaceutical Sciences, Toulouse, France; Department of Urology, Andrology and Renal Transplantation, Rangueil University Hospital, Toulouse, - - 2014
To compare the dose effect relationship of a selective β3 -adrenoceptor agonist (CL-316,243) on cystometric parameters in anesthetized and conscious rats and to evaluate its effect in a model of neurogenic bladder overactivity induced by spinal cord injury (SCI). Experiments were performed in anesthetized and conscious normal rats and in ...
Wu Zhen-Li ZL Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, - - 2014
Sclederma of Poria cocos (Hoelen) has been used as a diuretic in traditional Asian medicine. However, the underlying mechanism by which Sclederma of Poria cocos (hoelen) exerts its diuretic effect has not been well identified. The aim of the present study was to evaluate the effects of Sclederma of Poria ...
Hasegawa Takuro T Bozo Research Center - - 2014
3-(6-methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide (Cpd-D) is a novel glucokinase activator that is being developed for the treatment of type 2 diabetes. Large inter-individual variations were observed in the pharmacokinetics of Cpd-D in male Sprague-Dawley (SD) rats, which were subsequently divided into two phenotypes; >6-fold longer terminal-phase half-life and ~10-fold larger AUC0-∞ values ...
Kunze Allison A Department of Neurology, University of Washington School of Medicine, Seattle, WA, - - 2014
Fatigue and depression are common symptoms after stroke. Animal models of poststroke fatigue (PSF) and poststroke depression (PSD) would facilitate the study of these symptoms. Spontaneous locomotor activity is as an objective measure of fatigue and learned helplessness an accepted correlate of depression. We used different rat strains to evaluate ...
Buck Cara L CL Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California; Department of Psychology, University of California, San Diego, La Jolla, California. Electronic address: - - 2014
Rats emit 50kHz ultrasonic vocalizations (USVs) in situations of increased motivation, such as during the anticipation of palatable food or drugs of abuse. Whether the same holds true for the anticipation of alcohol intake remains unknown. Alcohol drinking in a nondependent state is thought to be mediated by its rewarding ...
Iio Wataru - - 2014
Suppression of body weight and symptom of anorexia are major symptoms of depression. Recently, we reported that chronic social defeat stress (CSDS) induced suppression of body weight gain and anorexic feeding behavior in rats. These abnormalities were the result of disrupted malonyl-coenzyme A (CoA) signaling pathway in the hypothalamus. However, ...
Lomanowska Anna M AM Department of Psychology, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada. Electronic address: - - 2014
Early-life social adversity, such as child neglect and institutionalized rearing, is associated with later-life difficulties of inhibitory control that may reflect altered attribution of salience to external stimuli. Studies in rats demonstrate that early-life social deprivation results in enhanced responsiveness to reward stimuli and conditioned reward cues. This study examined ...
Colombero Cecilia C Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, - - 2014
Thyroidectomy augments the natriuretic response to volume expansion; however, the mechanism remains unknown. This study assessed the role of 20-hydroxyeicosatetraenoic acid (20-HETE) in the natriuretic response to an acute volume expansion in hypothyroid rats. Urine flow (1.9-fold), sodium excretion (2.4-fold), fractional sodium excretion (3.8-fold), and distal delivery of sodium (4.1-fold) ...
Cheng Pei-Wen PW Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, - - 2014
Oxidative stress is an important pathogenic factor in the development of hypertension. Resveratrol, the main antioxidant in red wine, improves NO bioavailability and prevents cardiovascular disease. The aim of this study was to examine whether resveratrol decreases the generation of reactive oxygen species (ROS), thereby reducing BP in rats with ...
Shuvy Mony M Cardiovascular Research Center, Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: - - 2014
The effects of electromagnetic fields (EMFs) on cardiovascular calcification is unknown. We sought to evaluate the effects of EMF on vascular calcification in normal rats and in rats with chronic kidney disease (CKD) - a condition which promotes calcification. We used four groups of rats: group 1 - exposed to ...
Kim Jeong-Nam JN Department of Biomedical Laboratory Science, Masan University , Masan , Republic of Korea - - 2014
Abstract This study investigated the cycle of rat vibrissae by counting their number relative to their topographic arrangement. The average duration of maintaining single or double vibrissal shafts was analyzed. The ratio of the lifetime of the single and double shafts was around 3:2 weeks. The rostral and caudal vibrissae ...
Chen Guanghui G Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402460, China; Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, - - 2014
Major depressive disorder (MDD) is a debilitating mood disorder. However, the molecular mechanism(s) underlying depression remain largely unknown. Here, we applied a GC-MS-based metabonomic approach in the chronic unpredictable mild stress (CUMS) model, a well-established rodent model of depression, to investigate significant metabolic changes in the rat prefrontal cortex (PFC). ...
Pan Ying Y State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, P. R. - - 2014
Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β) may play a pivotal role in the central nervous system (CNS) inflammation of depression. Here, we investigated IL-1β alteration in serum, cerebrospinal fluid (CSF) and prefrontal cortex (PFC) of chronic unpredictable mild stress (CUMS)-exposed rats, a well-documented model of depression, ...
Xu Jianping J Department of Clinical Laboratory Medicine, Fujian Medical University, Fuzhou, PR - - 2014
Background/Aims: Nattokinase is a serine protease produced by Bacillus subtilis during the fermentation of the soybean product natto. The fibrinolytic activity and thrombolytic effects of nattokinase have been observed in vitro, but the effect in vivo has still to be researched. The objective of this study was to demonstrate the ...
Serra Maria Paola - - 2014
Abstract Purpose: Exposure to radiation primes the liver for extensive replacement of the resident parenchymal cells by transplanted hepatocytes. The mechanisms underlying this repopulation remain to be clarified. In these studies, we examined the possible occurrence of cell senescence in vivo following radiation-associated preconditioning of the host liver. Materials and ...
Smith Mark A MA Department of Psychology, Davidson College, Davidson, NC 28035, USA; Program in Neuroscience, Davidson College, Davidson, NC 28035, USA. Electronic address: - - 2014
Social learning models of substance use propose that drug-use behaviors are learned by observing and mimicking the behavior of others. The aim of this study was to examine the acquisition of cocaine self-administration in three groups of experimentally naïve rats: rats that were tested in isolation, rats that were tested ...
Chen Yu Y Fujian Medical University, Department of Physiology and Pathophysiology, Laboratory of Pain Research, Key Laboratory of Brain Aging and Neurodegenerative Diseases, Neuroscience Research Center, Fuzhou City, Fujian Province, 350108, P.R. - - 2014
Pain and learning memory have striking similarities in synaptic plasticity. Activation of the N-methyl-D-aspartic acid receptors 2B subunits (NR2B-NMDAs) is responsible for the hippocampal LTP in memory formation. In our previous study, we found the significant enhancement of CA1 hippocampal long-term potentiation (LTP) induced by high-frequency stimulation (HFS) in rats ...
Shumake Jason J Department of Psychology, The University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin, TX, 78712-1043, USA, - - 2014
Our objective was to characterize individual differences in fear conditioning and extinction in an outbred rat strain, to test behavioral predictors of these individual differences, and to assess their heritability. We fear-conditioned 100 Long-Evans rats, attempted to extinguish fear the next day, and tested extinction recall on the third day. ...
Winiarska Katarzyna K Department of Metabolic Regulation, Institute of Biochemistry, University of Warsaw, I. Miecznikowa 1, 02-096 Warsaw, Poland. Electronic address: - - 2014
Apocynin (4'-hydroxy-3'-methoxyacetophenone) is the most commonly used NADPH oxidase (Nox) inhibitor. However, its application raises serious controversies, as the compound has been reported to reveal some prooxidative effects. The aim of this study was to elucidate apocynin action on glutathione, the main intracellular antioxidant, metabolism in kidneys of Zucker diabetic ...
Yuksel Esra Pancar EP Esra Pancar Yuksel, MD, is Assistant Professor of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samson, Turkey. Fatih Ilkaya, MD, is Assistant Professor of Pharmacology at the Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Levent Yildiz, MD, is Professor of Pathology at the Department of Pathology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Fatma Aydin, MD, and Nilgun Senturk, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Hilal Denizli, MD, is a Resident in Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Tayyar Canturk, MD, and Ahmet Yasar Turanli, MD, are Professors of Dermatology at the Department of Dermatology, Faculty of Medicine, Ondokuz Mayis University, Samsun, - - 2014
The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats. This study has a randomized controlled experimental design. Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline ...
Bouzinova Elena V EV From the Department of Clinical Medicine (E.V.B., R.N., O.W.), Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine (D.M.B.B., A.M.J.M., O.K., C.A.,V.V.M), MEMBRANES, Aarhus University, Aarhus, Denmark; and Department of General Physiology (I.A.R.), St Petersburg State University, St Petersburg, - - 2014
Cardiovascular diseases have high comorbidity with major depression. Endothelial dysfunction may explain the adverse cardiovascular outcome in depression; therefore, we analyzed it in vitro. In the chronic mild stress model, some rats develop depression-like symptoms (including "anhedonia"), whereas others are stress resilient. After 8 weeks of chronic mild stress, anhedonic ...
Seckin E E Department of Otolaryngology Head and Neck Surgery, Ondokuz Mayis University School of Medicine, Samsun, - - 2014
Objective: This study aimed to determine the effect of radiofrequency radiation generated by 900 and 1800 MHz Global System for Mobile Communications sources on cochlear development in the rat model. Methods: Eight pregnant albino Wistar rats were divided into three groups: control, 900 MHz and 1800 MHz. The latter two groups of pregnant ...
Das Gupta Soumyasri S Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New - - 2014
Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary hyperplasia in ACI rats. ACI rats provide an established model of rodent mammary carcinogenesis due to ...
Gordon C J CJ Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA - - 2014
Abstract Setting exposure standards for environmental pollutants may consider the aged as a susceptible population but the few published studies assessing susceptibility of the aged to air pollutants are inconsistent. Episodic ozone (O3) is more reflective of potential exposures occurring in human populations and could be more harmful to the ...
Liang Hai Dong HD Hands and Feet Microsurgery, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of - - 2014
To explore the mechanism of soybean isoflavones (SI) on OVX-induced osteoporosis, we investigated the effect of SI on Wnt signaling that emerged as a novel key pathway for promoting bone formation. Results showed that SI decreased bone mineral elements loss, improved biomechanics parameters in OVX rats. Wnt3a activation can promote ...
Zhang Qi Q Geriatric Department of the Affiliated Provincial Hospital of Anhui Medical University, Anhui Institute of Cardiovascular Disease, Hefei, 230001, China, - - 2014
Disequilibrium of the cytokine network was reported to play an important role in the progression of chronic heart failure (CHF). Catechin exerts cardioprotection through treating many kinds of angiocardiopathy. However, the effects of catechin on CHF are currently unclear. Therefore, the main aim of this study was to investigate the ...
Zinkhan Erin K EK Neonatology, University of Utah, Salt Lake City, UT, - - 2014
Background:Maternal tobacco smoke (MTS) predisposes human and rat offspring to visceral obesity in early adulthood. Glucocorticoid excess also causes visceral obesity. We hypothesized that in utero MTS would increase visceral adiposity and alter the glucocorticoid pathway in young adult rats.Methods:We developed a novel model of in utero MTS exposure in ...
Takaku Tomoyuki T Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 1-98, 3-Chome, Kasugade-Naka, Konohana-Ku, Osaka 554-8558, Japan. Electronic address: - - 2014
A physiologically based pharmacokinetic (PBPK) model was developed to predict the concentration of flumioxazin, in the blood and fetus of pregnant humans during a theoretical accidental intake (1000mg/kg). The data on flumioxazin concentration in pregnant rats (30mg/kg po) was used to develop the PBPK model in pregnant rats using physiological ...
Chaudagar Kiranj K KK a Department of Pharmacology, L.M. College of Pharmacy, Opp. Gujarat University, Navarangpura, Ahmedabad 380009, - - 2014
Atorvastatin, a lipid lowering agent, possesses various pleiotropic vasculoprotective effects, but its role in coronary angiogenesis is still controversial. Our objective was to study the effects of atorvastatin on the angiogenic responsiveness of coronary endothelial cells (cEC) from normal and diabetic rats. Male Wistar rats were distributed among 9 groups; ...
Tomonari Hiroshi H Department of Oral Physiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, - - 2014
Neural responses to sweet and bitter stimuli in the rat and mouse are compared to the expression of the molecular taste receptors, Tas1r2/Tas2rs. Integrated taste responses from the greater superficial petrosal nerve (GSP) innervating the soft palate (SP) and the chorda tympani (CT) nerve innervating the fungiform papillae (FF) were ...
Desai Bhavna N BN Georgia Regents - - 2014
Continuous subcutaneous administration of leptin normalizes blood glucose levels in rodent models of type 1 and type 2 diabetes independent of changes in food intake, body weight and plasma insulin. We tested whether an acute intravenous leptin infusion changed blood glucose in normal and diet-induced leptin resistant rats to determine ...
Kendig Michael D MD School of Psychology, University of Sydney, Building A18, Sydney, NSW 2006, - - 2014
The metabolic consequences of providing rats with extended access to sugar solutions have varied across studies. The two experiments in this study examined the effects of 8weeks of 24-h access to 10% sucrose solution on adult Wistar rats. This was followed by 6weeks of food restriction with no access to ...
Sil Susmita S Neurophysiology Laboratory, Department of Physiology, University College of Science and Technology, University of Calcutta, Kolkata, - - 2014
Background: The components of the immune system have been indicated to be linked with the neurotoxicity in Alzheimer's disease (AD). The participation of the immune system in the neurodegeneration in a rat model of colchicine-induced AD has not been explored. Methods: In the present study, hippocampal neurodegeneration along with reactive ...
Sadek Km K 1Department of Biochemistry, Faculty of Veterinary Medicine, Damanhur University, - - 2014
Background:Fasting has been recently discovered to improve overall health, but its beneficial effects in the presence of hepatic insufficiency have not been proven.Aim:The influence of fasting on the metabolism, immunological aspects, and oxidative stress of 40 male carbon tetrachloride (CCl4)-intoxicated Wistar rats was investigated in the present study.Methods:The rats were ...
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