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Xiang Wen-Ping WP Department of Neurology, Center Hospital of Baotou, Inner Mongolia, - - 2014
We aimed to investigate the potential mechanism (s) of delayed encephalopathy after acute carbon monoxide (CO) poisoning in rats, and the effect of dexamethasone on this process. A delayed encephalopathy animal model was generated by intraperitoneal injection of CO into Wistar rats. Normal rats were sent as a control group, ...
Korashy H M HM Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi - - 2014
Aim: Combined use of herbs and drugs may result in clinically important herb-drug interactions. The majorities of these interactions are thought to be metabolism-based and involve induction or inhibition of cytochrome P450 (CYP). The current study was designed to investigate the effect of some commonly used herbs on rat CYP2C11 ...
Mattes W W PharmPoint Consulting, 17014 Hersperger Ln, Poolesville, MD 20837, - - 2014
While conventional parameters used to detect hepatotoxicity in drug safety assessment studies are generally informative, the need remains for parameters that can detect the potential for hepatotoxicity at lower doses and/or at earlier time points. Previous work has shown that metabolite profiling (metabonomics/metabolomics) can detect signals of potential hepatotoxicity in ...
Gaspar Andréia Fresneda AF Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, - - 2014
Background: Combination therapy can play a significant role in the amelioration of several toxic effects of lead (Pb) and recovery from associated cardiovascular changes. Objective: To investigate the effects of combination therapy on the cardiovascular effects of perinatal lead exposure in young and adult rats Methods: Female Wistar rats received ...
Karthick V V Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, - - 2014
Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic ...
Wang Liang L Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing, 400016, - - 2014
Approximately 30 % of epilepsy cases are refractory to current pharmacological treatments. Thus, novel therapeutic approaches that prevent or reverse the molecular and cellular mechanisms of epilepsy are required. 5-HT6 receptor (HTR6) blockade can modulate multiple neurotransmitter systems, and HTR6 may be a potential therapeutic treatment for neurological diseases, including epilepsy. ...
Ma Yuanwu Y Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, 100021, - - 2014
The type II bacterial CRISPR/Cas system is a very valuable genome-engineering tool, which has been widely used in genome editing of variety of organisms. Previously, we generated the floxed alleles in rats by CRISPR/Cas9. Here, we successfully use two-cut strategy with one circular vector, which contains the exogenous cDNAs with ...
Kawamura Yuji Y Toxicology Laboratory, Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd. 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Electronic address: - - 2014
Transgenic rat mutation assays can be used to assess genotoxic properties of chemicals in target organs for carcinogenicity. Mutations in transgenes are genetically neutral and accumulate during a treatment period; thus, assays are suitable for assessing the genotoxic risk of chemicals using a repeated-dose treatment paradigm. However, only a limited ...
He Jia J State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration, School of Environment, Northeast Normal University, Changchun, Jilin 130117, PR - - 2014
The aim of this paper was to investigate baseline toxicity to rats and effect of exposure routes on toxicity in rats and fish. In this paper, 1588 industrial chemicals were selected to investigate baseline toxicity to rats. The results showed that rat toxicity varies around a constant for classified compounds ...
Snelder Nelleke N Leiden - - 2014
A complicating factor in the translational pharmacology of sphingosine 1-phosphate (S1P) agonists is that they exert their pharmacological effect through their respective phosphate metabolites, which are formed by the enzyme sphingosine kinase (S1PHK). In this investigation, we present a semi-mechanistic pharmacokinetic model for the inter-conversion of S1PHK substrates and their ...
Luo Daishen D Harrington Biomedical Engineering, School of Biological Health Systems Engineering, Arizona State University, Tempe, Arizona, - - 2014
Application of focused ultrasound stimulation (FUS) to the rat cervix during pregnancy has significant physiologic effects. One-millisecond-long pulses of 680-kHz ultrasound with a repetition frequency of 25 Hz, at ISPTA (spatial-peak, temporal-average intensity) of 1, 2 and 4W/cm(2), were applied to the rat abdomen over the cervix. FUS produced a ...
Copeland Katrina W KW Department of Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA. Electronic address: - - 2014
The transient receptor potential ankyrin 1 (TRPA1) channel is activated by noxious stimuli including chemical irritants and endogenous inflammatory mediators. Antagonists of this channel are currently being investigated for use as therapeutic agents for treating pain, airway disorders, and itch. A novel azabenzofuran series was developed that demonstrated in vitro ...
Doorschodt B M BM Institute for Laboratory Animal Science & Experimental Surgery, Medical Faculty, RWTH-Aachen University, Aachen, - - 2014
The rat is the most widely used animal species in surgical research and offers distinct advantages over the mouse in transplantation models due to its size and close genetic similarity to humans. Sequencing of the rat genome and successful application of transgenic technologies which had only been available for mice ...
Johnson Wilbur W Jr Cosmetic Ingredient Review Senior Scientific Analyst, Washington, DC, - - 2014
Chlorphenesin functions as a biocide in cosmetics and is used at concentrations up to 0.32% in rinse-off products and up to 0.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that chlorphenesin was well absorbed when applied to the skin of rats; however, any safety concern was ...
Mejias Marc M Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), CIBERehd, Hospital Clinic, University of Barcelona, Barcelona, - - 2014
Antiangiogenic strategies have been proposed as a promising new approach for the therapy of portal hypertension and chronic liver disease. Pigment epithelium-derived factor (PEDF) is a powerful endogenous angiogenesis inhibitor whose role in portal hypertension remains unknown. Therefore, we aimed at determining the involvement of PEDF in cirrhotic portal hypertension ...
Zhang Feng F Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, P.R. China. - - 2014
Shengxian Decoction (SXT), a classic Traditional Chinese Medicine (TCM) prescription, consists of five TCMs: Astragali Radix, Anemarrhenae Rhizoma, Bupleuri Radix, Platycodonis Radix (PG), and Cimicifugae Rhizoma. SXT has been demonstrated to show good therapeutic effects on the cardiovascular system. A metabolomic approach was applied to study its therapeutic mechanisms and ...
Mattová Jana J Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Salmovska 1, 120 00 Prague 2, Czech - - 2014
Wilson's disease is a genetic disorder caused by a malfunction of ATPase 7B that leads to high accumulation of copper in the organism and consequent toxic effects. We propose a gentle therapy to eliminate the excessive copper content with oral administration of insoluble non-resorbable polymer sorbents containing selective chelating groups ...
Lasram Mohamed Montassar MM Laboratoire de physiologie des agressions: études métaboliques et endocriniens, Département de biologie, Faculté des sciences de Tunis, Université El-Manar , Tunis , Tunisie - - 2014
Abstract Malathion toxicity has been related to the inhibition of acetylcholinesterase, induction of oxidative stress, liver damage and impairment of kidney function as well as hematotoxicity. N-acetyl-l-cysteine (NAC) has been shown to possess curative effects in experimental and clinical investigations. The present study was designed to evaluate the protective effect ...
Méndez Lucía L Instituto de Investigaciones Marinas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, - - 2014
The study innovatively pinpoints target proteins of carbonylation, a key PTM induced by oxidative stress, in the SHROB (genetically obese spontaneously hypertensive) rat model of metabolic syndrome (MetS). Protein carbonylation was assessed by a fluorescence-labelling proteomics approach, and complemented with biometric and biochemical markers of MetS. SHROB and healthy Wistar ...
Guyon Laurie L Department of Gynaecology and Obstetrics, Lille University Hospital, Lille, France; INSERM, U703, Univ Lille Nord de France, Lille University Hospital, Lille, - - 2014
While Photodynamic therapy (PDT) is a promising treatment for peritoneal carcinomatosis, its use is often limited because of the toxicity of photosensitizers. In this study, safety of PDT with hexaminoevulinate (HAL), a second generation photosensitizer, is assessed. PDT of the peritoneal cavity was performed in a rat model of peritoneal ...
Rodrigo Teresa - - 2014
In two experiments, male and female rats were trained in a Morris pool in the presence of 1 (Experiment 1) or 2 (Experiment 2) landmarks, which were placed relatively close in relation to a hidden platform. Experiment 1 established the relative salience of 3 landmarks. Two of them revealed a ...
Liu Ai-Bo AB Department of Pathogenic Biology, Chongqing Medical University, Chongqing, - - 2014
This study was designed to investigate the therapeutic efficacy of chitosan on Pneumocystis pneumonia (PCP) in immunosuppressed rats. The PCP rat model was established using intramuscular injections of dexamethasone sodium phosphate. To estimate treatment effects of chitosan on rat PCP, weight gain, lung weight, lung weight/body weight (LW/BW) ratio and ...
Sun Zhi-Kun ZK Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, Henan 450002, P.R. - - 2014
Resveratrol is a natural polyphenol widely present in plants, particularly in the skin of red grapes and in wine. It possesses a wide range of biological effects and exhibits neuroprotective effects in numerous diseases. However, data evaluating the effects of resveratrol in vascular dementia (VaD) are lacking. In the present ...
Fangel Renan R 1 Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, SP - - - 2014
Purpose: The aim of this study was to investigate the effects of laser therapy and Biosilicate® on the biomechanical properties of bone callus in osteopenic rats. Methods: Fifty female Wistar rats were equally divided into 5 groups (n=10/group): osteopenic rats with intact tibiae (SC); osteopenic rats with unfilled and untreated ...
Chen Jiayi J School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, - - 2014
Zhi-Shao-San (ZSS), a traditional Chinese medicinal prescription, has been clinically used for the treatment of irritable bowel syndrome (IBS) for centuries. A comparative study was designed and conducted to compare the pharmacokinetic differences between paeoniflorin naringin, hesperidin and neohesperidin after oral administration of ZSS decoction to normal rats and IBS ...
Eichenbaum G G Janssen Research & Development, LLC, A Division of Janssen Pharmaceutical Companies of Johnson & Johnson, Department: 1000 Route 202 South, Raritan, NJ 08869, USA. Electronic address: - - 2014
The development path described for JNJ-26489112 provides perspectives on interpretation of retinal effects observed in nonclinical studies and their implications for clinical development. JNJ-26489112 is a CNS-active investigational drug that has potential as a novel treatment for treatment-resistant and bipolar depression, epilepsy, and neuropathic/inflammatory pain. In a 6-month toxicity study ...
Bhatti Mehwish M Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea - - 2014
Human preferences depend on whether a chosen outcome appears to be a loss or a gain compared with what had been expected, i.e., in comparison to a reference point. Because reference dependence has such a strong influence on human decision-making, it is important to uncover its origins, which will in ...
Liu Xia X Department of Analytical Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, - - 2014
Aim:To test the hypothesis that the traditional Chinese medicine Cordyceps sinensis could improve the metabolic function of extrarenal organs to achieve its anti-chronic kidney disease (CKD) effects.Methods:Male SD rats were divided into CKD rats (with 5/6-nephrectomy), CKD rats treated with Cordyceps sinensis (4 mg•kg-1•d-1, po), and sham-operated rats. After an ...
Waters R Parrish RP NeuroCure Cluster of Excellence, Charité Universitätsmedizin, Charité Platz 1, 10117, Berlin, Germany, - - 2014
Relapse is a primary obstacle in the treatment of addiction disorders, and as such, understanding this phenomenon is a major effort of clinical and preclinical studies of cocaine addiction. A recently developed protocol uses laboratory rats to model cocaine addiction by examining three criteria of addiction-like behaviors (persistent seeking in ...
Pinto H H Instituto de Investigaciones para las Especialidades Esteticas y del Envejecimiento, Barcelona. - - 2014
New knowledge about crystallization vs. lipid-to-gel transition has surfaced recently, since some of the latest publications on lipocryolysis have focused on its action mechanism. As a result, new opportunities for technical improvements and clinical outcome optimization have opened up. The food industry has been working with lipid crystal polymorphisms for ...
Chaanine A H AH Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, - - 2014
Adeno-associated virus (AAV)-based vectors are promising vehicles for therapeutic gene delivery, including for the treatment for heart failure. It has been demonstrated for each of the AAV serotypes 1 through 8 that inhibition of the proteasome results in increased transduction efficiencies. For AAV9, however, the effect of proteasome inhibitors on ...
Theilmann Wiebke W Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany; Center for Systems Neuroscience, Hannover, - - 2014
Electroconvulsive therapy is the most effective therapy for major depressive disorder (MDD). The remission rate is above 50% in previously pharmacoresistant patients but the mechanisms of action are not fully understood. Electroconvulsive stimulation (ECS) in rodents mimics antidepressant electroconvulsive therapy (ECT) in humans and is widely used to investigate the ...
Li Nan N Graduate School of Dalian Medical University, Dalian, 116044, People's Republic of - - 2014
Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis (Houpo), has been shown to exhibit anti-inflammatory and antioxidant properties. Here, we investigated the effects of honokiol on sepsis-associated AKI in rats ...
Luther Neal N Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York (N.L., Z.Z.); Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (P.Z., J.H.); Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (N.-K.C.); Department of Pathology, Emory University, Atlanta, Georgia (M.A.E.); Department of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York - - 2014
Reasons for failure in prior human glioma convection-enhanced delivery (CED) clinical trials remain unclear. Concentration-dependent volume of distribution (Vd) measurement of CED-infused agents in the human brain is challenging and highlights a potential technical shortcoming. Activity of iodine isotope 124 ((124)I ) in tissue can be directly measured in vivo ...
Kumar Sarwa Khomendra K Department of Pharmaceutical Sciences, Dibrugarh University , Dibrugarh, Assam , India - - 2014
Abstract In this study, topical ethosomal formulation of capsaicin was prepared and evaluated for bio-efficacy in arthritic rats. Physical and biological characterizations of prepared capsaicin-loaded nano vesicular systems were also carried out. Ethosomal capsaicin showed significant reduction of rat paw edema along with promising antinociceptive action. The topical antiarthritic efficacy ...
Yu Ying Y 1] Center for Pharmacogenomics, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai 201203, China - - 2014
The rat has been used extensively as a model for evaluating chemical toxicities and for understanding drug mechanisms. However, its transcriptome across multiple organs, or developmental stages, has not yet been reported. Here we show, as part of the SEQC consortium efforts, a comprehensive rat transcriptomic BodyMap created by performing ...
Habert Rene R R Habert, INSERM U 967 - CEA, Université Paris Diderot, F-92120 - Fontenay aux roses, - - 2014
Fetal testis is a major target of endocrine disruptors (EDs). During the last twenty years, we have developed an organotypic culture system that maintains the function of the different fetal testis cell types and used this approach as a toxicological test to evaluate the effects of various compounds on gametogenesis ...
Lorenzo-Zúñiga Vicente V Endoscopy Unit, Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. Electronic address: - - 2014
The aim of the present study was to develop a rat model of colonic microperforation secondary to thermal injury for future studies to assess new treatments. Twenty-four male Sprague-Dawley rats were used in this study. Hot biopsy forceps were used for all treatments. All lesions were created in proximal left ...
Feshitan Jameel A JA Department of Mechanical Engineering, Materials Science and Engineering Program, University of Colorado, Boulder, CO 80309, - - 2014
Severe hypoxemia refractory to pulmonary mechanical ventilation remains life-threatening in critically ill patients. Peritoneal ventilation has long been desired for extrapulmonary oxygenation owing to easy access of the peritoneal cavity for catheterization and the relative safety compared to an extracorporeal circuit. Unfortunately, prior attempts involving direct oxygen ventilation or aqueous ...
Roman-Campos Danilo D Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. Electronic address: - - 2014
Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing TD presents based on both electrocardiogram and echocardiogram ...
- - 2014
[This corrects the article DOI: 10.1371/journal.PONE-D-13-26510.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0077588.].
Perepechaeva M L ML Institute of Molecular Biology and Biophysics of Siberian Branch of RAMS, Timakova Street 2, Novosibirsk 630117, - - 2014
The mitochondria-targeted antioxidant SkQ1 is a novel drug thought to retard development of age-related diseases. It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test ...
Youcef Gina G UMRS U1116 Inserm, Vandoeuvre-lès-Nancy, France; Fédération de Recherche 3209, Nancy, France; Université de Lorraine, Nancy, France; Genomics Research Unit, Centre de Recherche Public de la Santé, Strassen, - - 2014
Individuals with metabolic syndrome (MetS) are prone to develop heart failure (HF). However, the deleterious effects of MetS on the continuum of events leading to cardiac remodeling and subsequently to HF are not fully understood. This study characterized simultaneously MetS and cardiac, vascular and renal phenotypes in aging Spontaneously Hypertensive ...
Beyazyıldız Emrullah E Department of Ophthalmology, Samsun Research and Training Hospital, Kıranköy Mevkii, 55100 Samsun, - - 2014
Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridine labeled MSCs ...
Arora Sumeha S 0000-0003-2957-799X Department of Microbiology, Panjab University, Basic Medical Sciences Building, BMS Block Panjab University, Chandigarh 160014, - - 2014
Alcohol-related disorders are one of the challenging current health problems with medical, social, and economic consequences. Endotoxemia, oxidative stress, and release of a variety of inflammatory molecules are established mediators in alcoholic liver injury (ALD). Probiotics like L. plantarum though were reported to attenuate ALD, their in vivo health benefits ...
Bowen Joanne M JM 0000-0003-0876-0031 School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, - - 2014
Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understanding of EGFR TKI-induced diarrhoea has been limited to clinical observation. However, our group ...
Morriss Grant A GA Landcare Research, Lincoln, New - - 2014
Stoats (Mustela erminea) and ship rats (Rattus rattus) in New Zealand are targeted by trapping to mitigate their predation on native wildlife. Internationally recognized guidelines for assessing the effectiveness and welfare performance of kill traps are supported by New Zealand legislation under the Animal Welfare Act 1999. The Victor® Easy ...
Wang Weijie W Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ; Key Laboratory of Systems Biomedicine verified by Ministry of Education, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, - - 2014
Hepatic stellate cells (HSCs) transdifferentiation and subsequent inflammation are important pathological processes involved in the formation of cirrhotic portal hypertension. This study characterizes the pathogenetic mechanisms leading to cholestatic liver fibrosis and portal hypertension, and focuses on mammalian target of rapamycin (mTOR) pathway as a potential modulator in the early ...
Nakamura Katsuyuki K Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, - - 2014
Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disorder caused by mutations in the Dmd gene encoding Dystrophin. DMD model animals, such as mdx mice and canine X-linked muscular dystrophy dogs, have been widely utilized in the development of a treatment for DMD. Here, we demonstrate the generation of ...
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