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Erbaş Oytun O Department of Physiology, Gaziosmanpaşa University, School of Medicine, Tokat, - - 2014
Schizophrenia is known to be associated with metabolic disturbances including diabetes mellitus, obesity and cardiovascular diseases. A growing body of evidence has suggested abnormal cytokine levels in schizophrenia. In the present study, we explored the effects of low-grade chronic inflammation on behavioral stereotypy in a rat model of non-alcoholic fatty ...
Peak J N JN School of Biomedical Sciences, The University of Queensland, St Lucia, - - 2014
Developmental vitamin D (DVD) deficiency is a plausible risk factor for schizophrenia that has been associated with behavioural alterations including disruptions in latent inhibition and response inhibition. The rodent gambling task (rGT) assesses risk-based decision-making, which is a key cognitive deficit observed in schizophrenia patients. The primary aim of this ...
Letcher Robert J RJ Ecotoxicology and Wildlife Health Division, Wildlife and Landscape Science Directorate, Science and Technology Branch, National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada. Electronic address: - - 2014
Perfluorooctane sulfonate (PFOS) has been reported to be among the most concentrated persistent organic pollutants in Arctic marine wildlife. The present study examined the in vitro depletion of major PFOS precursors, N-ethyl-perfluorooctane sulfonamide (N-EtFOSA) and perfluorooctane sulfonamide (FOSA), as well as metabolite formation using an assay based on enzymatically viable ...
Romero-Pimentel A L AL Centro de Investigación en Reproducción Animal (CIRA), Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, CP 90070, México; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, - - 2014
The neonatal ventral hippocampal lesion (NVHL) is an established neurodevelopmental rat model of schizophrenia. Rats with NVHL exhibit several behavioral, molecular and physiological abnormalities that are similar to those found in schizophrenics. Schizophrenia is a severe psychiatric illness characterized by profound disturbances of mental functions including neurophysiological deficits in brain ...
Hao Yongxin Y Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China. Electronic address: - - 2014
Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of Interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar rats were used along with the auditory ...
Fronczek-Sokół Justyna J Department of Pharmacology, Medical University of Silesia, Sosnowiec, Poland. Electronic address: - - 2014
Diabetes mellitus type 2 and osteoporosis are major health problem, especially in postmenopausal women. Glimepiride is a third-generation sulfonylurea derivative and is used as a first-line drug in the treatment of type 2 diabetes mellitus. The effect of this drug on bone tissue is unknown. The aim of the present ...
Maier-Salamon Alexandra A Department of Clinical Pharmacy and Diagnostics, University of Vienna, A-1090 Vienna, - - 2014
The metabolism of 9-aminocamptothecin (9-AC) was investigated in human and rat liver microsomes. In both species 9-AC was almost exclusively biotransformed to dihydroxy-9-AC (M1) and monohydroxy-9-AC (M2). The enzymatic efficiencies of the formation of M1 and M2 (Vmax/Km) were 1.7- and 2.7‑fold higher in rat than in human liver microsomes ...
Yang Kyunghee K University of North Carolina at Chapel - - 2014
Inhibition of bile acid transport by TGZ and its major metabolite, TGZ sulfate (TS), may lead to hepatocellular accumulation of toxic bile acids; TS accumulation and hepatotoxicity may be associated with impaired TS biliary excretion. This study evaluated the impact of impaired breast cancer resistance protein (Bcrp) and multidrug resistance-associated ...
Zeng Zhi Z Department of Pharmacology, Sun Yat-sen University, Guangzhou, 510080, - - 2014
Zicao is a traditional wound healing herbal medicine that has been used for several hundred years in China. A survey of the published literatures revealed that arnebin-1, one of the naphthoquinone derivatives, played the most important role in wound healing property of this plant. However, whether arnebin-1 affects angiogenesis in ...
Schachter David D M D Columbia University College of - - 2014
The leucine-to-glutamate(Leu-Glu)pathway, which metabolizes the carbon atoms of L-leucine to form L-glutamate, was studied by incubating rat tissue segments with L-[U-(14)C]leucine and estimating the [(14)C]glutamate formed. Metabolism of the leucine carbon chain occurs in most rat tissues, but maximal activity of the Leu→Glu for glutamate formation is limited to the ...
Nafisi Sara - - 2014
Abstract Acetaminophen (N-acetyl para amino phenol, APAP) is a widely used antipyretic and analgesic drug responsible for various drug-induced liver injuries. This study evaluated APAP-induced toxicity in isolated rat hepatocytes alongside the protective effects of silafibrate and N-acetyl cysteine (NAC). Hepatocytes were isolated from male Sprague-Dawley rats by collagenase enzyme ...
Ueda Yukari Y Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima, 770-8514, - - 2014
The aim of this study was to examine whether cultured rat thoracic aortic endothelial cells (TAECs) have the ability to metabolize the tertiary amine, imipramine. In rat TAECs, imipramine was biotransformed into N-demethylate and N-oxide by cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO), respectively. The intrinsic clearance (V max/K m) ...
Diao Xingxing X Shanghai Institute of Materia Medica, Chinese Academy of - - 2014
3-n-Butylphthalide (NBP) [(±)-3-butyl-1(3H)-isobenzofuranone] is an anti-cerebral ischemia drug. Moderate hepatotoxicity has been observed in clinic. 3-N-acetylcysteine-NBP, one of the major metabolites, has been detected in human urine, indicating the formation of reactive metabolite. The aim of the present study is to elucidate the formation mechanism of reactive metabolite and its ...
Berry Loren M LM Amgen, - - 2014
The mammalian target of rapamycin (mTOR) is a protein kinase that shows key involvement in age-related disease and promises to be target for treatment of cancer. In the present study the elimination of potent ATP-competitive mTOR inhibitor 3-(6-amino-2-methylpyrimidin-4-yl)-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine (compound 1) is studied in bile duct cannulated rats, and the metabolism ...
Hurwitz Zachary M ZM From the Division of Plastic Surgery, University of Massachusetts Medical School, North Worcester, - - 2014
Seroma formation is a well-recognized complication associated with many operative procedures. Despite its ubiquity, a lack of definitive scientific understanding of the etiology, natural history, and biochemistry of seromas remains. We endeavored to create and examine seromas in a rat model in the setting of commonly used biologic implants and ...
Wang Wenbin W Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, 215000, - - 2014
Deep venous thrombosis (DVT) is one of the common peripheral vascular diseases. The recruitment and migration of bone marrow-derived endothelial progenitor cells (EPCs) to the sites of venous thrombus are necessary in the process of thrombus organization and recanalization. Our objective was to investigate the functional role of miR-150 in ...
Harms Lauren L School of Psychology, University of Newcastle, Callaghan, NSW, Australia; Priority Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia; Schizophrenia Research Institute, Darlinghurst, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, - - 2014
Mismatch negativity (MMN) is a scalp-recorded electrical potential that occurs in humans in response to an auditory stimulus that defies previously established patterns of regularity. MMN amplitude is reduced in people with schizophrenia. In this study, we aimed to develop a robust and replicable rat model of MMN, as a ...
Ozkan U U Department of Neurosurgery, Dumlupinar University Medical Faculty, Kütahya, Turkey. - - 2014
An animal model of laminectomy in rats was used to study scar tissue formation around the spinal cord. Bevacizumab (BV) [a recombinant, humanized, monoclonal antibody targeting vascular endothelial growth factor], 5-Fluorouracil (5-FU) and BV+5-FU was tested in this system for its ability to decrease fibrous tissue formation. Twenty-eight Sprague Dawley ...
Berhanu Workalemahu M WM Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of - - 2014
Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques. These fibrils may either be toxic by themselves, or act as reservoirs for smaller cytotoxic oligomers. This suggests to investigate molecules as potential therapeutics that ...
Takahara Yuka Y Faculty of Pharmaceutical Sciences, Okayama - - 2014
Butylbenzyl phthalate (BBzP) is used as a plasticizer to import flexibility to polyvinylchloride plastics. In this study, hydrolysis of BBzP to monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) in liver microsomes of humans, monkeys, dogs, rats and mice was examined. The kinetics for MBP formation by human, dog and mouse ...
Turkoglu Erhan E Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Neurosurgery Clinic, Ankara, - - 2014
The formation of epidural fibrosis adjacent to the dura mater after posterior spinal surgery is a normal reaction of the body to surgery. Extensive epidural fibrosis is one of the important causes of postlaminectomy syndrome. Etanercept inhibits tumor necrosis factor-alpha and decreases fibroblast migration. Thus, etanercept prevents the formation of ...
Zhang Hao H China Rehabilitation Research Center, Capital Medical University, Beijing, - - 2014
The effects of growth hormone on cognitive dysfunction were observed in a controlled cortical impact (CCI) rat model and the underlying mechanism was explored. Three-month-old male SD rats were randomly divided into sham (n = 10), control (n = 10), and CCI groups (n = 40) The parameters were set as follows: striking speed, 3.5 m/s; ...
Hu Qin Q Department of Physiology and Pharmacology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda CA 92354, - - 2014
Approximately 40% of hemorrhagic stroke survivors develop hydrocephalus. Hyperbaric oxygen (HBO) has been shown to be anti-inflammation following experimental stroke; however, its effect upon post-hemorrhagic hydrocephalus formation is not known. The objective of this study is to investigate whether HBO therapy can effectively reduce hydrocephalus formation and improve neurobehavioral functions ...
Mitomi T - - 2014
The antineoplastic bifunctional-alkylating agent busulfan (Bu) induces developmental anomalies. We examined histopathological changes in the molar roots of rats that received Bu at different stages of root formation. At different developmental stages, i.e., on postnatal days (P) 13, 15, and 19, rats were administered 7.5 mg/kg of Bu dissolved in ...
Le Yuan Y Department of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. - - 2014
It is known that age is an important factor for postoperative cognitive dysfunction (POCD) and the patients with POCD suffer from the impairment of multiple brain regions and multiple brain functions. However currently animal studies of POCD mainly focus on hippocampus region, therefore in this study we performed partial hepatectomy ...
Zhang Zhiguo Z 0000-0001-8626-8611 Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, - - 2014
The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia. Our results show that RDE could inhibit bone loss of OVX rats after a 12-week treatment. The microarray analysis showed that 68 genes were upregulated ...
Sakuma Eisuke - - 2014
We investigated the effect of leptin on the postnatal development of gap junctions between folliculo-stellate cells by using Zucker fatty (fa/fa) rats that have defects of the functional leptin receptor. Male Zucker fatty rats (fa/fa) and male Zucker lean rats (+/+) were used at each of the following postnatal ages: ...
Wang J J Department of Nutrition and Food Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing, - - 2014
Phytoestrogens have been suggested as alternative treatment for postmenopausal osteoporosis. Equol, a metabolite of daidzein, has been shown to inhibit bone loss in ovariectomized mice and rats. However, whether or not equol influences the formation of bone has not yet been investigated. Therefore, we investigated the effect of equol on ...
Turkoglu Erhan E Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, 06110, Ankara, Turkey. Electronic address: - - 2013
The formation of epidural fibrosis adjacent to the dura mater is a complex multi-step process that is associated with a marked reduction in tissue cellularity and the excessive deposition of extracellular matrix components. Extensive epidural fibrosis is a major cause of post-laminectomy syndrome. Decorin strongly inhibits fibrosis formation in various ...
Yoshida Tadashi - - 2013
High phosphate-induced phenotypic switching of smooth muscle cells (SMCs) into osteogenic cells is critical for the formation of arterial medial calcification in chronic kidney disease. Because vascular calcification is also prevalent in type 2 diabetes, we examined whether glucose concentration affects high phosphate-induced SMC phenotypic switching and calcification. First, the ...
Adewale Adetutu - - 2013
Vegetables are the cheapest and most available sources of important proteins, minerals, vitamins, and essential amino protein. These vegetables are commonly used in Africa for the treatment of illness. This study evaluated the protective effects of Amaranthus caudatus and A. hybridus against sodium arsenite-induced toxicity in rats. The effects of ...
Lu Zhe - - 2013
Changes in atropisomer composition of chiral polychlorinated biphenyls (PCBs) and their mono- and di- hydroxylated metabolites (OH- and diOH-PCBs) via rat cytochrome P450 2B1 (CYP2B1) mediated biotransformation were investigated in vitro. Rat CYP2B1 could stereoselectively biotransform chiral PCBs to generate meta-OH-PCBs as the major metabolites after 60 min incubations. Non-racemic ...
Pianalto Kaila M - - 2013
CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol). The dose response of DNA and protein adducts derived from BD metabolites increase linearly at low BD exposures and then saturate at higher exposures in rats, but not mice. It was hypothesized that differences ...
Reza Eskandari Mohammad - - 2013
Thallium(I) is a highly toxic heavy metal; however, up to now, its mechanisms are poorly understood. The authors' previous studies showed that this compound could induce reactive oxygen species (ROS) formation, reduced glutathione (GSH) oxidation, membrane lipid peroxidation, and mitochondrial membrane potential (MMP) collapse in isolated rat hepatocyte. Because the ...
Chen Xiao - - 2013
Low level of cadmium (Cd) exposure may enhance osteoclasts formation in vitro. The aim of the study was to observe the effects of Cd on osteoclasts formation in vivo. Sprague-Dawley male rats were divided into 4 groups which were given Cd via drinking water at concentrations of 0, 2, 10 ...
Marklund M - - 2013
Two phenolic acids, 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)- propanoic acid (DHPPA), are the major metabolites of cereal alkylresorcinols (ARs). Like their precursors, AR metabolites have been suggested as biomarkers for intake of whole-grain wheat and rye and as such could aid the understanding of diet-disease associations. This study estimated and ...
Alhusainy Wasma - - 2013
The present work investigates whether the previous observation that the basil flavonoid nevadensin is able to inhibit sulfotransferase (SULT)-mediated estragole DNA adduct formation in primary rat hepatocytes could be validated in vivo. Estragole and nevadensin were co-administered orally to Sprague-Dawley rats, at a ratio reflecting their presence in basil. Moreover, ...
Chang Wen-Chang - - 2013
The unbalance of glucose metabolism in human may cause the excessive formation of methylglyoxal (MG) which can react with various bio-molecules to form the precursor of advanced glycation end products (AGEs). Vescalagin (VES) is an ellagitannin that alleviates insulin resistance in cell study. The present study found the preventive effect ...
Frye Cheryl Anne CA Department of Psychology, The University at Albany-SUNY, Albany, NY, USA. - - 2013
Progesterone (P4 ) and its product, 5α-pregnan-3α-ol-20-one (3α,5α-THP), act in the midbrain ventral tegmental area (VTA) to alter motivated behaviors, such as mating, and motor and anxiety behavior. Of interest is whether 3α,5α-THP formation requires the pregnane xenobiotic receptor (PXR), which is expressed in the midbrain of rats. The role ...
Kraatz Brian P - - 2013
Cane rats (Thryonomyidae) are represented today by two species inhabiting sub-Saharan Africa. Their fossil record is predominately African, but includes several Miocene species from Arabia and continental Asia that represent dispersal events from Africa. For example, Paraulacodus indicus, known from the Miocene of Pakistan, is closely related to living Thryonomys. ...
Rave-Fränk Margret - - 2013
The liver is considered a radiosensitive organ. However, in rats, high single-dose irradiation (HDI) showed only mild effects. Consequences of fractionated irradiation (FI) in such an animal model have not been studied so far. Rats were exposed to selective liver FI (total dose 60 Gy, 2 Gy/day) or HDI (25 Gy) and were ...
Jorge G L - - 2013
Biliary complications after liver procedures can lead to morbidity and poor survival. The aim of this study was to evaluate the hepatic function after quick clamping of the common bile duct (BD) in Wistar rats. Twelve male Wistar rats with a mean weight of 323.14 g were anesthetized with sodium ...
Ukairo Okechukwu - - 2013
Primary hepatocytes display functional and structural instability in standard monoculture systems. We have previously developed a model in which primary hepatocytes are organized in domains of empirically optimized dimensions and surrounded by murine embryonic fibroblasts (HepatoPac™). Here, we assess the long-term phenotype of freshly isolated and cryopreserved rat hepatocytes in ...
Stiborova Marie - - 2013
Sudan I (1-phenylazo-2-hydroxynaphthol) is a suspected human carcinogen causing tumors in liver and urinary bladder in rats, mice, and rabbits. Here we investigated for the first time the influence of Sudan I exposure on the expression of several biotransformation enzymes in livers, kidneys, and lungs of rats concomitantly at the ...
Circi Esra - - 2013
The aim of this study was to examine the effect of oophorectomy in the formation of epidural fibrosis in a rat laminectomy model. Thirty-six 12-month-old adult female Sprague-Dawley rats were used in this study. Rats were evenly divided into two groups; oophorectomized and sham-operated. Bilateral oophorectomy was performed on the ...
Khalil Issam Tanios IT Assistant Professor, Department of Endodontics, Saint Joseph University, Lebanon, e-mail: - - 2013
Aim: To compare the histomorphological response of rat dental pulps capped with MM-MTA and ProRoot MTA at 1, 2 and 4 weeks postoperatively. Materials and methods: Direct pulp capping with MM-MTA and ProRoot MTA, overlaid with light-cured composite resin, was performed on right and left maxillary frst molars of 20 ...
Wang Xiong - - 2013
The study investigated the pharmacodynamism and mechanism of Chinese medicinal formula-Huiru Yizeng Yihao (NO.1 HRYZ) on the model rats of hyperpro-lactinemia and the model rats of hyperplasia of mammary gland (HMG), and studied the internal connection between hyperprolactinemia and HMG.. The hyperprolactinemia rat models were established by injecting metoclopramide dihydrochloride ...
Shahraki Jafar J School of Pharmacy, Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, P.O.Box 14155-6153, Iran. ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, - - 2013
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to ...
Yan Tao - - 2013
Diabetes mellitus (DM) plays an important role in the pathogenesis of vascular complications including arteriosclerosis and ischemic stroke. Whether DM impacts intracranial aneurysm (IA) formation has not been extensively investigated. In this study, we tested the underlying mechanism of type one DM (T1DM) induced IA formation in rats. T1DM was ...
Sliwiński Leszek L Department of Pharmacology, Medical University of Silesia, Katowice, Jagiellońska 4, PL 41-200 Sosnowiec, Poland. - - 2013
Background: Propranolol, a nonselective β-adrenergic receptor antagonist, was reported to favorably affect the skeletal system in different animal models. The aim of the study was to investigate whether the effects of propranolol on the skeletal system depend on the estrogen status. Methods: The in vivo experiments were carried out on ...
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