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Fajfr M - - 2014
Purpose: The evaluation of four post-pandemic influenza seasons 2009-2013 in the Faculty hospital Hradec Králové and comparison of used rapid antigen tests (RATs) with real time RT-PCR. Material and methods: Between November 2009 and June 2013 were examined 3845 samples from patients with respiratory tract infections by RATs (Influenza A/B ...
Chang Qi Q Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China ; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong - - 2014
Oseltamivir (OA), an ethyl ester prodrug of oseltamivir carboxylate (OC), is clinically used as a potent and selective inhibitor of neuraminidase. Chinese medicines have been advocated to combine with conventional drug for avian influenza. The current study aims to investigate the potential pharmacokinetic and pharmacodynamic interactions of a Chinese medicine ...
Zhang Hengyan - - 2013
Study Design. follow-up of animals after surgically initiated scoliosisObjective. To develop quantitatively asymmetric loads on rat lumbar to create scoliosisSummary of Background Data. Current animal models for scoliosis use mostly rigid or flexible posterior asymmetric tethers. The curve progression can only be expected for the growth potential, leading to insufficient ...
Bisht Swati - - 2013
The study aims to explore the antihyperglycemic activity of Acacia tortilis polysaccharide isolated from the gum exudate. α-D-Glucosidase from Saccharomyces cerevisiae and rat small intestine was used as in-vitro model to assess α-D-glucosidase inhibitory activity of the polysaccharide against yeast and mammalian enzyme. The reduction in postprandial blood glucose level ...
Pan Ke - - 2013
Extraction of Ganoderma lucidum polysaccharides (GLP) was optimized by response surface method (RSM). By running the optimization program with design expert within the experimental range investigated, the following optimum values were obtained: extraction time 230min; extraction temperature 95°C, and extraction number 5. The predicted polysaccharides production was 1.45%. Results showed ...
Cheng Poh-Guat PG Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia ; Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, - - 2013
Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus. In this study, we ...
Goessens Wil H F - - 2013
The efficacies of tigecycline and ceftazidime against fatal pneumonia in rats caused by an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain or its wild-type (WT) progenitor were compared. Ceftazidime at 12.5 or 50 mg/kg of body weight twice daily (b.i.d.) was effective (50% or 100% rat survival) in pneumonia caused by ...
Zhong Yu-Sen - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: Orthosiphon stamineus (OS) popularly known as "diuretic agent" are traditionally used in folk medicine in the treatment of hyperuricemia, rheumatism, gout, nephritis, nephrolithiasis, urethritis and cystitis. AIM OF THE STUDY: To evaluate prophylactic potentials of total flavonoids, total phenolics and polysaccharides from OS on experimental induction of calcium ...
He Chang-Sheng - - 2012
Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other ...
Doran Angela C - - 2012
Recent publications suggest interstitial fluid compound concentrations (C(ISF)) best determine quantitative neurotherapeutic pharmacology relationships, although confirming large animal C(ISF) remains elusive. Accordingly, this work primarily evaluated using respective acute-dose rat-derived unbound brain compound concentration-to-unbound plasma compound concentration ratios (C(b,u):C(p,u)) to project accurately dog and nonhuman primate (nhp) C(b,u), a C(ISF) ...
Sharma Raman - - 2012
The disposition of (3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone (PF-00734200), a DPP-IV inhibitor which progressed to Phase 3 for the treatment of type II diabetes, was examined in rats, dogs and humans after oral administration of a single dose of [(14)C]PF-00734200. Mean recoveries of administered radioactivity were 97.1, 92.2 and 87.2% in rats, dogs and ...
Desvars Amélie - - 2012
Our objective was to identify local animal reservoirs of leptospirosis to explain the unusual features of Leptospira strains recently described among patients on the island of Mayotte. By means of a microscopic agglutination test using local clinical isolates, we found that 11.2% of black rats were seropositive to Leptospira, whereas ...
Jonsson Ove - - 2012
Background: Capillary microsampling (CMS) is a new technique for simplified collection, handling and analysis of small, exact volumes of liquid matrices. CMS was compared with conventional large volume sampling, in toxicology studies in rat and dog. Results: Bioanalytical validation data were well within acceptance limits. Toxicokinetic (TK) parameters from microsampling ...
Schwen Richard J - - 2012
S-equol is a natural product that is produced by the microbial biotransformation of daidzein, an isoflavone found in soy. Evidence suggests that the health benefits of soy may be related to one's ability to produce S-equol, thus S-equol is being developed for the treatment of vasomotor symptoms in postmenopausal women. ...
Mao Yu - - 2012
SIM010603, a promising multi-targeted receptor tyrosine kinase (RTK) inhibitor, is now being considered for evaluation in phase clinical trial. In this work, the subchronic toxicity of SIM010603 in SD rats and beagle dogs have been characterized. Rats and dogs received SIM010603 orally (0-20 and 0-10mg/kg/day, respectively) on a consecutive daily ...
Anosike Chioma A - - 2012
To evaluate the possible anti-inflammatory effect of garden egg [Solanum aethiopicum (S. aethiopicum)] using experimentally induced inflammatory models in rats. Oedema was induced on the rat hind paw by the injection of 0.1 mL undiluted fresh egg albumin (philogistic agent) into the subplantar surface of the rat paw. Tissue granuloma ...
Yang Cui-Ping - - 2011
To investigate the interference of rat feed to pharmacokinetic of flavonoids. Flavonoids in rat feed and plasma samples were separated by rapid resolution reversed-phase HPLC and characterized by LC-ESI-MS/MS analysis with an electrospray ionization source (ESI) and a triple quadrupole analyzer by fragmentation pattern. Five Citrus flavonoids (naringin, naringenin, quercetin, ...
Ortak Huseyin - - 2011
In this study, we aimed to investigate the distribution pattern of ubiquitin and p97/VCP in the rat retina during postnatal development. Eyeballs from 1-, 4-, 10-, 36- and 72-week-old rats were examined by immunohistochemistry, and protein colocalization was determined by immunofluorescence microscopy. In the 1-week-old rat retina, p97/VCP was strongly ...
Jena Srikanta - - 2011
The present study was carried out to elucidate the effectiveness of curcumin in ameliorating the expression of superoxide dismutase (SOD) in cerebral cortex and cerebellum of rat brain under 6-propyl-2-thiouracil (PTU)-induced hypothyroidism. Induction of hypothyroidism in adult rats by PTU resulted in augmentation of lipid peroxidation (LPx), an index of ...
Seda Artis A - - 2011
Background:  Manipulations of thyroid hormones have been shown to influence learning and memory. While a large body of literature is available on the effect of thyroid hormone deficiency on learning and memory functions during the developmental stage, electrophysiological and behavioral findings, particularly on propylthiouracil administration to adult normothyroid animals, are ...
Chang In Youb - - 2011
Cholesterol transport proteins are a prerequisite for neurosteroidogenesis. Steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain-containing proteins, such as StAR and START domain-containing 6 (StarD6), are known to be distributed in the brain. Since perinatal hypothyroidism affects cerebellar development, we examined postnatal changes in StAR and StarD6 immunolocalization in ...
Ukaji Takao - - 2011
We determined the sequence of the immunoglobulin gamma heavy-chain constant (IGHC) region of the Mongolian gerbil (Meriones unguiculatus). To isolate a part of the IGHC complementary DNA, we designed primers on the basis of highly conserved sequences in mouse, rat and hamster. The deduced IGHC is structurally similar to counterparts ...
Suzuki Hiroshi - - 2011
The potential genotoxicity of the rodent liver carcinogen 2,6-dinitrotoluene (2,6-DNT) was evaluated in compliance with the guidelines for genotoxicity studies of drugs (Notification No. 1604, Nov. 1, 1999, Ministry of Health and Welfare, Japan) and the OECD guidelines for the testing of chemicals by performing the bacterial reverse mutation (Ames) ...
Dasarathy Srinivasan - - 2011
The portacaval anastamosis (PCA) rat is a model to examine nutritional consequences of portosystemic shunting in cirrhosis. Alterations in body composition and mechanisms of diminished fat mass following PCA were examined. Body composition of male Sprague-Dawley rats with end-to-side PCA and pair-fed sham-operated (SO) controls were studied 3 wk after ...
Bu Na - - 2011
Three minor sulfur-containing arsenic metabolites: monomethylmonothioarsonic acid (MMMTA(V)), dimethylmonothioarsinic acid (DMMTA(V)), and dimethyldithioarsinic acid (DMDTA(V)) were recently found in human and animal urine after exposure to inorganic arsenic. However, it remains unclear how the thioarsenicals are formed in the body and then excreted into the urine. It is hypothesized that ...
Mannaa Fathia F Medical Physiology Department, National Research Centre, Dokki, - - 2011
To evaluate the action of fish liver oil and propolis in pilocarpine epileptic rats treated with the anticonvulsant drug valproate. Seven groups of rats were treated daily for six months: control; fish liver oil (0.4ml/kg b.w); propolis (50mg/kg b.w); pilocarpine-treated rats (epileptic control); epileptic rats treated with valproate (400mg/kg b.w); ...
Klump Kelly L - - 2011
Puberty is a critical risk period for binge eating and eating disorders characterized by binge eating. Previous research focused almost entirely on psychosocial risk factors during puberty to the relative exclusion of biological influences. The current study addressed this gap by examining the emergence of binge eating during puberty in ...
Xing Jian-feng JF Department of Pharmacy, Medical College, Xi-an Jiaotong University, Xi-an 710061, - - 2011
To study the metabolic and pharmacokinetic profile of scutellarin, an active component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz, and to investigate the mechanisms underlying the low bioavailability of scutellarin though oral or intravenous administration in rats. HPLC method was developed for simultaneous detection of scutellarin and scutellarein (the ...
Agrati Daniella - - 2011
The sexually active female rat solicits the male to approach for copulation, while the maternal dam displays aggression to expel him from the nest, suggesting that both behaviors are mutually exclusive. However, the rat has a postpartum estrus during which she is sexual and maternally motivated. Can she perceive the ...
Seita Yasunari - - 2011
For preservation of rat spermatozoa, the general-purpose method requires that the male be sacrificed for collection of spermatozoa from the epididymides. However, it would be highly useful if the ejaculated spermatozoa could be successfully cryopreserved and the frozen-thawed spermatozoa used for in vitro fertilization, since this would allow the genetically ...
Jolles Jolle W - - 2011
Conformity refers to the act of changing one's behaviour to match that of others. Recent studies in humans have shown that individual differences exist in conformity and that these differences are related to differences in neuronal activity. To understand the neuronal mechanisms in more detail, animal tests to assess conformity ...
Brown Cyndi - - 2011
Urinary tract catheterization of the rat may be required for a variety of clinical and experimental reasons. The external urinary orifice is easily visualized and rests anterior to the vaginal opening, making urinary tract catheterization easier in the female rat than in other species. This column describes a technique for ...
Sakhai Samuel A SA Department of Psychology, University of California at Berkeley, Berkeley, CA 94720, USA. - - 2011
In mammals, maternal care influences the developing offspring across multiple domains. In Long Evans rats, for example, the quality of maternal care received as a pup influences later cognitive function, neuroendocrine responses to stress and behavioral measures of emotionality. Data from humans, non-human primates, and rodents also suggest that early ...
Kaur Gill-Sharma Manjeet - - 2011
During spermiogenesis, the elongating rat spermatid chromatin undergoes a gradual process of condensation which is initiated in the round spermatids at "step 7" of cytodifferentation in stage VII and extending to elongated spermatids at "step 19" of cytodifferentiation in stage VIII. The mechanism of chromatin condensation in the elongating spermatids ...
Koyama Naoki - - 2011
The recent discovery that the potent carcinogen acrylamide (AA) is present in a variety of fried and baked foods raises health concerns, particularly for children, because AA is relatively high in child-favoured foods such as potato chips and French fries. To compare the susceptibility to AA-induced genotoxicity of young versus ...
Koelsch Bernd Ulrich - - 2011
We previously mapped several gene loci influencing cancer risk of inbred BDIV and BDIX rats, resistant and susceptible, respectively, to Ethylnitrosourea (ENU)-induced malignant peripheral nerve sheath tumors (MPNST). On the basis of a genome wide association analysis using a (BDIV x BDIX) F(2) generation the Mss4 locus on rat chromosome ...
Choudhury Sujata Maiti - - 2011
Mycotoxin MT81 was isolated, purified, and identified from a fungal strain of Penicillium nigricans. It is a CNS depressant, hyperglycemic agent and produces massive bone marrow depression, hepatotoxicity, and nephrotoxicity. Its benzolylated analog (benzoylated-MT81) was synthesized in our laboratory having a LD(50) value of 87.1 mg/kg body weight in mice. This ...
Winland Carissa - - 2011
The present study evaluated the effects of methamphetamine (MA) on sexual behavior in female rats. In Experiment 1, ovariectomized, hormone-primed rats were injected with MA (1.0mg/kg, i.p.) or saline prior to a test for mate choice wherein females could mate with two males simultaneously. Female rats treated with saline returned ...
Gupta Rajnish - - 2011
This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. Phytochemical examination showed that plant is rich in active constituents, i.e. α-amyrin acetate, lupeol acetate, α-amyrin, β-amyrin, lupeol and thevetigenin. T. peruviana stem bark methanol extract (TPMtE) administered orally ...
Jobling M S MS MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, - - 2011
Environmental factors are implicated in increased incidence of human testicular germ-cell cancer (TGCC). TGCC has foetal origins and may be one component of a testicular dysgenesis syndrome (TDS). Certain phthalates induce TDS in rats, including effects on foetal germ cells (GC). As humans are widely exposed to phthalates, study of ...
Shimada Hideaki - - 2011
We have previously reported that inbred Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced testicular toxicity compared with inbred Fischer 344 (F344) rats. The present study was to elucidate the genetic background of resistance to Cd-induced testicular toxicity in WI rats. The genetic analysis of susceptibility to Cd-induced testicular ...
Tousson Ehab - - 2011
The thyroid hormone has few serious effects on the testes except during the neonatal stage. There is little knowledge concerning the prolonged effect of thyroid hormone deficiency throughout the rat's life span and its effect on spermatogenesis. Proliferating cell nuclear antigen (PCNA) is a nuclear matrix protein, which is essential ...
Johnson Kamin J - - 2011
Fetal rat phthalate exposure produces a spectrum of male reproductive tract malformations downstream of reduced Leydig cell testosterone production, but the molecular mechanism of phthalate perturbation of Leydig cell function is not well understood. By bioinformatically examining fetal testis expression microarray data sets from susceptible (rat) and resistant (mouse) species ...
Hao Yuhui - - 2011
This two-generation study evaluated the effects of depleted uranium (DU) on reproductive toxicity in male and female rats. Across two generations, Wistar rats (48/sex/group) were maintained on feed containing DU at dose levels of 0 (control), 4, or 40 mg kg(-1) day(-1) for 4 months prior to mating. Compared with the control group, the ...
Sainath S B - - 2011
The purpose of the present study was to investigate the effects of prenatal exposure to octylphenol (OP) at the dose of 50mg/kg body weight on days 1, 7 and 14 of pregnancy on reproductive health of male rats at adulthood. F1 male rats from control and OP exposed animals were ...
Di Viesti Vittoria - - 2011
To evaluate the influence of Humulus lupulus extract on sexual behavior in female rats. Ovariectomized rats hormonally primed with estradiol benzoate (1.5 μg/rat) and progesterone (500 μg/rat) were acutely treated by oral gavage with Humulus lupulus extract dosed at 5, 10 and 25mg/kg and then tested for partner preference and ...
Julien Sylvie - - 2011
Age-related macular degeneration (AMD) is associated with lipofuscin accumulation whereas the content of melanosomes decreases. Melanosomes are the main storage of zinc in the pigmented tissues. Since the elderly population, as the most affected group for AMD, is prone to zinc deficit, we investigated the chemical and ultrastructural effects of ...
Dammann Philip - - 2011
African mole-rats (Bathyergidae, Rodentia) contain several social, cooperatively breeding species with low extrinsic mortality and unusually high longevity. All social bathyergids live in multigenerational families where reproduction is skewed towards a few breeding individuals. Most of their offspring remain as reproductively inactive "helpers" in their natal families, often for several ...
Ren Longquan L Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, - - 2011
The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3, 5, 7, 14, 30, 60, ...
Beconi Maria G - - 2011
To evaluate the potential of memantine as a therapeutic agent for Huntington's disease (HD) we have undertaken a series of in vitro, ex vivo and whole animal studies to characterize its pharmacokinetics (PK) and pharmacodynamics (PD) in rats and mice. Results from these studies will enable determination of memantine exposures ...
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