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Oksayan Ridvan R Department of Orthodontics, Faculty of Dentistry, Gaziantep University, Gaziantep, - - 2014
The aim was to evaluate the effects of the use of mandibular advancement appliances on mandibular growth in growing rats. Twenty-four 8-week-old male Wistar albino rats were randomly divided into two experimental groups (12 rats each): Group I was a control group, and Group II was the mandibular advancement appliance ...
Sekulic Damir D 1Faculty of Kinesiology, University of Split, Teslina 6, Split-21000, Croatia 2University Department of Health Care Studies, University of Split, R. Boskovica 32 , Split-21000, - - 2014
The main objective of this study was to evaluate the reliability and validity of a newly constructed reactive-agility test that can be used to define reactive-agility performance in sports that employ a repeated scenarios of "stop'n'go" agility. Measuring is done by original hardware based on the ATMEL microcontroller AT89C51RE2. A ...
Weissgerber Tracey L TL Mayo - - 2014
Background: Free vascular endothelial growth factor (VEGF) is undetectable in plasma during human pregnancy. However, studies examining pregnant rats have reported both low (8-29 pg/mL) and high (527-1030 pg/mL) free VEGF. These discrepancies cast uncertainty over the use of rat models to study angiogenic factors in pregnancy and preeclampsia. This ...
Kelly Shane S 1Department of Immunopathology, ICPMR, Westmead Hospital 2Oral Immunology Clinic, Westmead Hospital, Westmead, NSW, - - 2014
Paraneoplastic pemphigus (PNP) is a rare autoimmune mucocutaneous blistering condition which has a universal association with malignancy and a poor prognosis. PNP, which is characterised by the presence of autoantibodies against plakins in the skin epithelial layer, can be a challenging diagnosis to make, particularly in those without an existing ...
Kelly Shane S 1Department of Immunopathology, ICPMR, Westmead Hospital 2Oral Immunology Clinic, Westmead Hospital, Westmead, NSW, - - 2014
Paraneoplastic pemphigus (PNP) is a rare autoimmune mucocutaneous blistering condition which has a universal association with malignancy and a poor prognosis. PNP, which is characterised by the presence of autoantibodies against plakins in the skin epithelial layer, can be a challenging diagnosis to make, particularly in those without an existing ...
Souza Guilherme Negrão - - 2013
Abstract Objective: To assess the local effect of hyaluronidase injection on the expression of glycosaminoglycans (GAGs) and proteoglycans (PGs) in the extracellular matrix of the uterine cervix from pregnant albino rats. Methods: Ten pregnant rats were divided into two groups on day 18 of pregnancy. The experimental group (Gexp) of ...
Li Shi-Yong - - 2013
This study investigated the role of glycogen synthase kinase-3β (GSK-3β) in isoflurane-induced neuroinflammation and cognitive dysfunction in aged rats. The hippocampi were dissected from aged rats which had been intraperitoneally administered lithium chloride (LiCl, 100 mg/kg) and then exposed to 1.4% isoflurane for 6 h. The expression of GSK-3β was ...
Poot A M - - 2013
Paraneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against plakins, desmogleins and the alpha-2-macroglobulin-like-1 (A2ML1) protein, in association with an underlying neoplasm. Accurate diagnosis relies on the demonstration of these autoantibodies in serum. To evaluate the value of different laboratory techniques in the serological diagnosis of PNP. We ...
Zhao Wei - - 2013
Renal aquaporin-2 (AQP2) is critical for maintaining water balance and is associated with hypertension. Anti-hypertensive drugs, including imidapril, improve kidney function; however, it remains unclear whether these effects are mediated through the regulation of AQP2. In this study, the effects of imidapril on AQP2 expression in the kidneys and excretion ...
Islam Md Ariful - - 2013
The aim of this study was to evaluate transmission of Brucella abortus biotype 1 via sexual intercourse in rats. Male and female virgin Sprague-Dawley (SD) rats were experimentally infected intraperitoneally with 1×10(9)colony forming units (CFU) of B. abortus biotype 1, a Korean bovine isolate. At 14 days after infection, infected ...
Hino Shingo - - 2013
We used recombinant rat dectin-1 proteins to newly establish sandwich ELISA for determining barley β-glucan (BβG). The ELISA method had a working range of 15-4,000 µg/L. Plasma BβG was detectable up to 24 h after an intravenous administration of BβG (1 mg/kg of body weight) to rats. This method may ...
Takasawa Hironao - - 2012
Detecting genotoxicity in the liver is considered an effective approach for predicting hepatocarcinogenicity, as many genotoxic chemicals in vivo may act as hepatocarcinogens in rodents. Here, a genotoxic rodent hepatocarcinogen, 1,2-dimethylhydrazine dihydrochloride (1,2-DMH), and a genotoxic (Ames positive) noncarcinogen, 2,6-diaminotolunene (2,6-DAT), were administered orally to rats for up to 28 ...
Li Yongbing - - 2012
BALB/c mice were immunized by highly immunogenic recombinant proteins containing amino acid sequence of integrin antagonist AP25. Antibody against AP25 was prepared and purified by affinity chromatography. An indirect enzyme-linked immunosorbent assay for qualitative analysis of AP25 in rat plasma samples was successfully established. The assay was successfully applied to ...
Mychasiuk R - - 2012
Autism is a highly debilitating disorder that has recently displayed a dramatic rise in incidence. In order to realistically study preventative and remedial strategies, it is important that we develop and understand useful animal models of the disorder. The purpose of this study was to investigate the efficacy of the ...
Kyme Andre - - 2012
Positron emission tomography (PET) is an important in vivo molecular imaging technique for translational research. Imaging unanaesthetized rats using motion-compensated PET avoids the confounding impact of anaesthetic drugs and enables animals to be imaged during normal or evoked behaviour. However, there is little published data on the nature of rat ...
Fischer Christina W - - 2012
Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour and physiology. The aim of this study was to investigate the effects of social isolation on behavioural and metabolic ...
Schneeberger Karin - - 2012
Although evolutionary models of cooperation build on the intuition that costs of the donor and benefits to the receiver are the most general fundamental parameters, it is largely unknown how they affect the decision of animals to cooperate with an unrelated social partner. Here we test experimentally whether costs to ...
Khan Adil Ghani - - 2012
Tracking odour trails is a crucial behaviour for many animals, often leading to food, mates or away from danger. It is an excellent example of active sampling, where the animal itself controls how to sense the environment. Here we show that rats can track odour trails accurately with near-optimal sampling. ...
Stryjek Rafał - - 2012
The purpose of the present study was to analyse species-specific forms of behaviour (digging and swimming) and response to novelty in laboratory rats and their wild type counterparts at a very early stage of laboratorization. Three behavioural phenomena were taken into account: burrowing, spontaneous swimming, and neophobic behaviour. Wild-type rats ...
Wang Kun - - 2011
Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC(50) values of 75.3 and 72.8 μM against rat intestinal sucrase, and 63.4 and ...
Wada Kunio - - 2011
Conducting the single-cell gel electrophoresis (Comet) assay in the urinary bladders of rodents is technically problematic because the bladder is small and thin, which makes it difficult to collect its mucosal cells by scraping. We performed the Comet assay using a simple mincing method in which tissues are minced with ...
Wang Miao - - 2011
(-)Doxazosin, one of (±)doxazosin enantiomers, was speculated to have a pharmacological enantioselectivity between the cardiovascular system and the urinary system by comparison with (+)doxazosin. Therefore, to evaluate the potential benefits of (-)doxazosin in the treatment of benign prostate hyperplasia, we compared the effects of the 3 agents, using rat mesenteric ...
Ma Bing-Liang - - 2011
Rhizoma coptidis is a rhizome commonly used in traditional Chinese medicine. Interestingly, after the oral administration of Rhizoma coptidis extract, the plasma concentrations of its effective alkaloid constituents are so low that their systemic therapeutic actions cannot be explained. This study aims to investigate the influence of lipopolysaccharide (LPS) on ...
Lewis Bethany K H - - 2011
  Rat bite fever is a rare but potentially fatal Gram-negative infection that predominantly affects populations with exposure to rats, notably children. The clinical presentation is nonspecific and requires a high threshold of suspicion to elicit a history of rat exposure. We report here a case of a child whose ...
Ma Bing-Liang - - 2011
AIM OF THE STUDY: Rhizoma coptidis is a traditional Chinese medicine with pharmacological properties. It is usually prescribed with Fructus evodiae as traditional Chinese medicine (TCM) formulas. Here we report the influences of Fructus evodiae on the pharmacokinetics of the Rhizoma coptidis alkaloids and propose possible mechanisms. MATERIALS AND METHODS: ...
Tokgöz Hüsnü - - 2011
OBJECTIVE: To compare 3 kinds of topical hemostatic agents in terms of adhesive strength, control of hemorrhage, and postoperative intra-abdominal adhesions in an experimental partial nephrectomy (PN) model. METHODS: A total of 27 Wistar rats were divided into 5 groups. PN was performed in 6 rats (control group) with the ...
Nishijima Saori - - 2011
We examined the influence of propiverine hydrochloride, an anticholinergic agent, on the micturition reflex, blood pressure, and plasma catecholamine levels in young rats and old rats. Male F344/DuCrlCrlj Fischer rats (young rats aged 2 months and old rats aged 26 months) were divided into the following 4 groups: a young ...
Wisler John A - - 2011
Seven novel and potent Raf small molecule kinase inhibitors (C1-7) were evaluated in seven-day oral repeat dose rat toxicity studies. All compounds tested induced hyperplasia in multiple tissues. Consistently affected was stratified squamous epithelium at a number of sites and transitional epithelium of urinary bladder and kidney. A seven-day time ...
Owen Suzzanne J - - 2011
AIMS: Development of urinary incontinence, for many women, occurs following menopause. Dietary phytoestrogens consumed over the long term may affect the contractile function and maintenance of the urinary bladder in post menopausal women. This study examined the muscarinic receptor mediated contractile responses in the rat isolated bladder in response to ...
Ramos-Filho Antonio C S - - 2011
AIMS: Association between arterial hypertension and urinary bladder dysfunction has been reported in humans and spontaneously hypertensive rats. However, no study exists evaluating the bladder dysfunction in conditions of renovascular hypertension. The purpose of this study was to characterize the bladder dysfunction in two kidney-one clip (2K-1C) hypertensive rats. METHODS: ...
Lee Wei-Chia - - 2011
PURPOSE: We studied bladder motor dysfunction and searched for markers of neurogenic and myogenic alterations among fructose fed rats with or without abnormal voiding behavior. MATERIALS AND METHODS: Female Wistar rats were fed with a fructose rich diet (60%) or a normal diet for 6 months. Based on cystometry and ...
Miranda A A Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. - - 2011
The objective of this study was to determine if neonatal cystitis alters colonic sensitivity later in life and to investigate the role of peripheral mechanisms. Neonatal rats received intravesical zymosan, normal saline, or anesthesia only for three consecutive days [(postnatal (PN) days 14-16)]. The estrous cycle phase was determined prior ...
Juszczak Kajetan - - 2011
This study was designed to investigate the effects of melatonin on the bladder hyperactivity in hyperosmolar-induced overactive bladder (OAB) rats. Additionally, the influence of melatonin on the autonomic nervous system (ANS) using heart rate variability (HRV) analysis was assessed. 40 rats were divided into four groups: I--control (n = 12), ...
Brudzynski Stefan M - - 2011
Effects of direct injections of amphetamine into the shell of the nucleus accumbens were studied in three lines of Long-Evans rats, two of which had been selected for low and high rates of 50 kHz calls in adolescence in response to a standard social stimulation, and compared to results from ...
Arnold Jonathon C - - 2010
AIMS: Genetic disposition modulates the psychoactive effects of cannabis. Cannabinoids have a greater impact on brain regions that subserve anxiety in Wistar compared to Lewis strain rats. Here we aim to show that this correlates with strain differences in cannabinoid-induced anxiety-related behaviour. MAIN METHODS: Lewis and Wistar rats were administered ...
Yadav Chetan K - - 2010
Dynamics of exploratory behaviour of rats and home base establishment is investigated. Time series of instantaneous speed of rats was computed from their position during exploration. The probability distribution function (PDF) of the speed obeys a power law distribution with exponents ranging from 2.1 to 2.32. The PDF of the ...
Palomero-Gallagher N - - 2010
Circling behaviour of the ci2 rat mutant has been associated with an abnormal laterality concerning nigrostriatal and vestibular dopamine content and densities of several neurotransmitter receptors. Since not only subcortical, but also cortical activity subserve behavioural asymmetry, we applied quantitative in vitro receptor autoradiography to determine the densities of twenty ...
Abou-Ismail Usama A - - 2010
This experiment was carried out to investigate the long-term effects of enhancing cage complexity on behavioural measures of welfare in laboratory rats. We housed 72 rats in groups of four in either 'enriched' or 'unenriched' cages for six weeks. Scan and focal animal sampling were conducted in both the light ...
Abou-Ismail Usama A - - 2011
This experiment was carried out to investigate the effects of enriching laboratory cages on agonistic interaction and dominance of rats. In a series of three replicates, 48 rats were housed in groups of four in either 'standard' or 'enriched' cages for 6 weeks. Successful aggressive and defensive behaviour that ended ...
Natusch C - - 2010
Rats utter distinct classes of ultrasonic vocalizations depending on their developmental stage, current state, and situational factors. One class, comprising the so-called 50-kHz calls, is typical for situations where rats are anticipating or actually experiencing rewarding stimuli, like being tickled by an experimenter, or when treated with drugs of abuse, ...
Wright Jennifer M - - 2010
RATIONALE: 50-kHz ultrasonic vocalizations (USVs) emitted by adult rats are heterogeneous; they occur over a wide frequency range, show varying degrees of frequency modulation, and appear to differ in their behavioral significance. However, they have not been extensively categorized. OBJECTIVES: The main objective of this study was to identify subtypes ...
Narayanan Sareesh Naduvil - - 2010
The interaction of mobile phone radio-frequency electromagnetic radiation (RF-EMR) with the brain is a serious concern of our society. We evaluated the effect of RF-EMR from mobile phones on passive avoidance behaviour and hippocampal morphology in rats. Healthy male albino Wistar rats were exposed to RF-EMR by giving 50 missed ...
Saucier Deborah M - - 2010
In previous work from our laboratory, we have developed a model of stroke that allows the comparison of stroke injury across age groups (10-day old, 63-day old, 180-day old rats). In this current study, we incorporated environmental enrichment to determine whether this form of rehabilitation alters behavioral recovery, and whether ...
Cavigelli Sonia A - - 2010
As a first step in determining the influence of maternal behaviour on sibling behavioural variance, we tested whether rat mothers differentially interact with neonates within the same litter. We also tested whether fading of an ink-mark on individual pups could provide an index of within-litter variance in maternal licking in ...
Nonkes Lourens J P LJ Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Dept. of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 GA Nijmegen, The - - 2010
A disturbance in 5-HT signalling can lead to maladaptive and disruptive behavioural changes seen in neuropsychiatric disorders, potentially by 5-HT's role in cognitive control over behaviour. 5-HT levels are tightly controlled by the serotonin transporter (5-HTT). We and others have observed that 5-HTT availability affects reversal learning. Here we investigated ...
Akcali Didem - - 2010
Behavioural animal studies are critical, particularly to translate results to human beings. Cortical spreading depression (CSD) has been implicated in migraine pathogenesis. We aimed to investigate the effects of CSD on the behaviour of freely moving rats, since available CSD models do not include awake animals. We developed a new ...
Goldkuhl Ren?e - - 2010
This study investigated the peri- and postoperative effect of pre-emptive analgesia through voluntary ingestion of buprenorphine in Nutella, in male Sprague-Dawley rats. An arterial catheter was inserted and the rats were connected to an automated blood sampling device (AccuSampler). Blood samples were drawn up to 18 h after surgery and ...
Mor D - - 2010
Neuropathic pain conditions for which treatment is sought are characterized by complex behavioural disturbances, as well as "pain." Recent studies using chronic constriction injury of the sciatic nerve have shown that rats develop three distinct patterns of disability characterized by changes in social-interactions and sleep-wake cycle behaviours post-injury: (i) Persistent ...
Viana Duarte S - - 2010
Game theory and the Prisoner's Dilemma (PD) game in particular, which captures the paradox of cooperative interactions that lead to benefits but entail costs to the interacting individuals, have constituted a powerful tool in the study of the mechanisms of reciprocity. However, in non-human animals most tests of reciprocity in ...
Lomanowska Anna M - - 2010
Increased sensitivity to the locomotor-activating effects of amphetamine in rats with a history of early-life social isolation is commonly attributed to alteration of the dopamine system. The locomotor response to amphetamine may also be due to effects on the noradrenergic system and particularly alpha-adrenergic receptors. The present study examined whether ...
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