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Kelly Shane S 1Department of Immunopathology, Pathology West, ICPMR, Westmead Hospital, Westmead 2Department of Oral Medicine, Oral Pathology and Special Care Unit, Westmead Hospital, Westmead, and Faculty of Dentistry, University of Sydney, Sydney 3Discipline of Medicine, Sydney Medical School, University of Sydney, Sydney, NSW, - - 2014
Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous blistering disease driven by autoantibodies against plakins expressed in mucosal epithelium. Diagnosis can be difficult as both clinical and biopsy features overlap with other blistering disorders, thus serology is important. Indirect immunofluorescence (IIF) on rat bladder substrate is the most widely used assay, ...
Suzuki Yui Y Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin, Co., Ltd., Japan; Veterinary Pathology, Osaka Prefecture University, Japan. Electronic address: - - 2015
Common marmosets (Callithrix jacchus) have become a useful animal model, particularly for development of biopharmaceuticals. While various renal failure models have been established in rodents, there is currently no acceptable model in marmosets. We analyzed the damaged renal tubules and tubulointerstitial changes (inflammation and fibrosis) of 5/6 nephrectomized (Nx) common ...
Shen Shanwei S Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, United - - 2014
The present study aims to systemically characterize the factors that are associated with urinary bladder organ enlargement in spontaneously hypertensive rats (SHRs). We compared the SHRs to age-matched normotensive Wistar-Kyoto (WKY) control rats in the levels of bladder pro-inflammatory factors, collagen expression (type I), and detrusor smooth muscle growth. Our ...
Zhang Haiying H Department of Urology, Yantai Hill Hospital, Yantai, Shandong 264001, P.R. - - 2014
Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease, which affects 10‑12% of the population in industrialized countries. In males, the highest prevalence of the disease occurs between the age of 20 and 40 years, while in females, the highest incidence of the disease ...
Ow Connie P C CP Monash - - 2014
Renal tissue oxygen tension (PO2) and its determinants have not been quantified in polycystic kidney disease (PKD). Therefore we measured kidney tissue PO2 in the Lewis rat model of PKD (LPK) and in Lewis control rats. We also determined the relative contributions of altered renal oxygen delivery and consumption to ...
Qi Xiaozhe X College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, - - 2014
Ochratoxin A (OTA) has displayed nephrotoxicity and renal carcinogenicity in mammals, however, no clear mechanisms have been identified detailing the relationship between oxidative stress and these toxicities. This study was performed to clarify the relationship between oxidative stress and the renal carcinogenicity induced by OTA. Rats were treated with 70 ...
Kirakosyan Ara A University of Michigan Health System, Cardiovascular Center and the Michigan Integrative Medicine Program, Ann Arbor, MI 48109, United States. Electronic address: - - 2015
Our aim was to confirm and identify the presence of tart cherry anthocyanins in several target tissues of healthy rats. Liquid chromatography-mass spectrometry analysis was employed for detection and characterisation of anthocyanin metabolites. It was shown that four native anthocyanins, namely cyanidin 3-glucosylrutinoside, cyanidin 3-rutinoside, cyanidin 3-rutinoside 5-β-d-glucoside, and peonidin ...
Chen Hui H Department of Urology, Renmin Hospital of Wuhan University , Wuhan , China - - 2014
Abstract Background: Ischemic postconditioning (IPoC) is defined as a series of intermittent interruptions of blood flow in the early phase of reperfusion that mechanically alters the hydrodynamics of reperfusion and it attenuates renal damage after ischemia/reperfusion (I/R) injury in vivo. But all of these data had been obtained in adult ...
Oshiro Takuma T Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, - - 2014
To confirm the mechanisms of age-associated detrusor underactivity (DU), we examined the differences in bladder activity and connexin-43 (Cx43)-derived gap junctions in the bladders of young and old rats. Female Sprague-Dawley rats aged 3months (young) and 12months (old) were used. Continuous cystometry was performed under urethane anesthesia in both ages ...
Kaushik M M Department of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, St Mary's Campus, London W2 1PG, - - 2014
Toxoplasma gondii is an indirectly transmitted protozoan parasite, of which members of the cat family (Felidae) are the only definitive hosts and small mammals such as rats serve as intermediate hosts. The innate aversion of rodents to cat odor provides an obstacle for the parasite against successful predation by the ...
Golcu Doruk D Department of Biology, Stanford University, Stanford, CA, USA. Electronic address: - - 2014
The protozoan Toxoplasma gondii (T.gondii) manipulates the behavior of its rodent intermediate host to facilitate its passage to its feline definitive host. This is accomplished by a reduction of the aversive response that rodents show towards cat odors, which likely increases the predation risk. Females on average show similar changes ...
Elamin Maha H MH Department of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi - - 2014
Toxoplasma 3 main clonal lineages are designated as type I, II, and III; however, atypical and mixed genotypes were also reported. This study was conducted for detection of Toxoplasma gondii genotypes in rats (Rattus rattus) in Riyadh region, Saudi Arabia. PCR test on T. gondii B1 gene was conducted on ...
Ayral F F WildTech, PERS,Université de Lyon-VetAgro Sup,Marcy - - 2014
SUMMARY Leptospira interrogans, hantaviruses (particularly Seoul virus), hepatitis E virus (HEV), and Toxoplasma gondii are rat-associated zoonoses that are responsible for human morbidity and mortality worldwide. This study aimed to describe the infection patterns of these four pathogens in wild rats (Rattus norvegicus) across socioeconomic levels in neighbourhoods in Lyon, ...
Johnson Martin M Division of Pharmacokinetics, Toxicology and Targeting, University of Groningen, University Centre for Pharmacy, Antonius Deusinglaan 1, Groningen, 9713 AV, The - - 2014
Dopamine D2 receptor occupancy (D2RO) is the major determinant of efficacy and safety in schizophrenia drug therapy. Excessive D2RO (>80%) is known to cause catalepsy (CAT) in rats and extrapyramidal side effects (EPS) in human. The objective of this study was to use pharmacokinetic and pharmacodynamic modeling tools to relate ...
Tay Sun Tee ST Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, and Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; Laboratory Animal Resource Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, - - 2014
This study describes our investigation on the prevalence and molecular identification of bartonellae from Rattus diardii and R. norvegicus in the urban areas of Malaysia. Of 95 rats investigated, Bartonella tribocorum, B. rattimassiliensis, B. coopersplainsensis, B. elizabethae, and B. queenslandensis were isolated from kidney and spleen homogenates of four rats. ...
Jittimanee Jutharat - - 2014
Leptospirosis, a zoonotic disease caused by Leptospira, has been a health problem in Thailand for several years. It can be transmitted to humans via rats' urine, which may contaminate the environment. The prevalence rate of Leptospira infection in rats may result in the spread of leptospirosis in humans. The present ...
Cirelli Kimberly M KM Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts, United States of - - 2014
Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome 10 containing Nlrp1. This gene encodes an inflammasome sensor controlling macrophage sensitivity ...
Billeter Sarah A SA 1 Centers for Disease Control and Prevention , Division of Vector Borne Diseases, Fort Collins, - - 2014
Abstract The presence of bartonellae in invasive rats (Rattus rattus) and indigenous rodents (Arvicanthis niloticus and Cricetomys gambianus) from two districts in Uganda, Arua and Zombo, was examined by PCR detection and culture. Blood from a total of 228 R. rattus, 31 A. niloticus, and 5 C. gambianus was screened ...
Laudisoit Anne A EEID, School of Biological Sciences, The University of Liverpool, Liverpool, United Kingdom; Evolutionary Ecology, University of Antwerp, Antwerpen, Belgium; University Clinic of Kisangani, Kisangani, Democratic Republic of the Congo; Science Faculty, University of Kisangani, Kisangani, DRC; Biodiversity Monitoring Center (Centre de Surveillance de la Biodiversité, CSB), Kisangani, DRC; Royal Belgian Institute of Natural Sciences, Brussels, Belgium; Faculty of Geosciences, University of Utrecht, Utrecht, The Netherlands; Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, 13005 Marseille, - - 2014
The prevalence and identity of Rickettsia and Bartonella in urban rat and flea populations were evaluated in Kisangani, Democratic Republic of the Congo (DRC) by molecular tools. An overall prevalence of 17% Bartonella species and 13% Rickettsia typhi, the agent of murine typhus, was found in the cosmopolitan rat species, ...
Yuan Yuan Y School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China ; Hainan Normal Universities, Haikou 571158, - - 2014
Alpinia oxyphylla (Zingiberaceae), an herbaceous perennial plant, its capsular fruit is commonly used in traditional Chinese medicine for the treatment of different urinary incontinence symptoms including frequency, urgency and nocturia. These symptoms are similar to the overactive bladder syndrome. In our lab, we found that the 95% ethanol extract of ...
Himsworth Chelsea G CG School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada ; Animal Health Centre, British Columbia Ministry of Agriculture, Abbotsford, British Columbia, - - 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of multi-drug-resistant infections in people, particularly indigent populations. MRSA can be transmitted between people and domestic animals, but the potential for transmission between people and commensal pests, particularly rodents, had not been investigated. The objective of this study was to identify the ...
Vasudevan Anand A School of Biological Sciences, Nanyang Technological University, Singapore, 637551, - - 2014
Many animals use chemicals as pheromones to communicate between individuals of the same species, for example to influence mate choice or to assert dominance. Pheromonal communication is an open broadcast system that can be intercepted by unintended receivers such as predators and prey. We have recently reported that male rats ...
Zou Rong R Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China ; Department of Nephrology, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, - - 2014
A 5/6 nephrectomized (Nx) rat model was employed to address the impact of telmisartan on CKD related renal injury and the underlying molecular mechanisms. It was noted that telmisartan provided protection for rats against 5/6 Nx induced lethality. Telmisartan treated 5/6 Nx rats manifested improved renal function as characterized by ...
Rowe Kevin C KC Sciences Department, Museum Victoria, Melbourne, Australia.; Email: - - 2014
The island of Sulawesi, in Indonesia, lies at the crossroads of the Indo-Australian Archipelago and has remained isolated from the Asian (Sunda) and Australian (Sahul) continental shelves for at least the last 10 million years. Of the 50 native species of rodents on Sulawesi, all are endemic and represent the ...
Costa Federico F 1 Centro de Pesquisas Gonçalo Moniz , Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, Bahia, Brazil - - 2013
Abstract Norway rats (Rattus norvegicus) are reservoir hosts for zoonotic pathogens that cause significant morbidity and mortality in humans. Studies evaluating the prevalence of zoonotic pathogens in tropical Norway rat populations are rare, and data on co-infection with multiple pathogens are nonexistent. Herein, we describe the prevalence of leptospiral carriage, ...
Wang Tao - - 2013
It is well known that toxoplasmosis can be life threatening to immunocompromised individuals such as AIDS and organ transplantation patients. Glucocorticoids (GCs) are widely used in the clinic for the treatment of autoimmune diseases and organ transplantation resulting in acute toxoplasmosis in these patients. However, the interaction and mechanism between ...
Zanet S - - 2013
Isolated environments are privileged settings to study transmission of infection. Montecristo is a small island where no wild or domestic carnivores are present. Invasive Black rats Rattus rattus (n=78) were captured and tested by PCR for Leishmania infantum, Toxoplasma gondii and Neospora caninum. We wanted to test, for these parasites, ...
Elliott John E - - 2013
Second-generation anticoagulant rodenticides are widely reported to contaminate and poison nontarget wildlife, primarily predatory birds and mammals. Exposure pathways, however, have not been well defined. Here, we examined potential movement of rodenticides from deployment of bait to exposure of small mammals and other biota. At two adjacent working farms, we ...
Zalewska A - - 2013
There is no study analyzing the salivary antioxidant profile in the course of the insulin resistance. Rats were divided into two groups. One group was fed with a normal diet, another one with a high fat diet for 5 weeks. The analysis included: catalase (CAT), superoxide dismutase, peroxidase activities, uric acid, ...
Hayman David T S - - 2013
Emerging pathogens that originate from invasive species have caused numerous significant epidemics. Some bacteria of genus Bartonella are rodent-borne pathogens that can cause disease in humans and animals alike. We analyzed gltA sequences of 191 strains of rat-associated bartonellae from 29 rodent species from 17 countries to test the hypotheses ...
Himsworth Chelsea G - - 2013
Leptospira interrogans is a bacterial zoonosis with a worldwide distribution for which rats (Rattus spp.) are the primary reservoir in urban settings. In order to assess, monitor, and mitigate the risk to humans, it is important to understand the ecology of this pathogen in rats. The objective of this study ...
Wang Chengmin - - 2013
Leptospirosis is a widely distributed zoonosis, and rats (Rattus spp.) are its most common source. We found antibodies to leptospires in 115 (30.2%) of 381 commensal rodents from Beijing, China. Commensal rodents might represent a potential source for human and pet leptospirosis in urban environments.
Theuerkauf Jörn - - 2013
Rats are major reservoirs of leptospirosis and considered as a main threat to biodiversity. A recent introduction of Rattus rattus to the island of Futuna (Western Polynesia) provided the opportunity to test if a possible change in species composition of rat populations would increase the risk of leptospirosis to humans. ...
Sashida Hinako - - 2013
The prevalence of hemotropic mycoplasmas in wild rodents is largely unknown. Here we report the presence of hemoplasmas in blood samples collected from brown sewer rats (Rattus norvegicus) trapped during rodent control around an animal hospital in Morioka, Japan. We examined nine rats using real-time PCR and end-point PCR, and ...
Ng-Hublin Josephine S Y - - 2013
In order to examine the prevalence of Cryptosporidium in wild rodents in the Philippines and understand the role wild rodents play in the transmission of this parasite to humans and livestock, 194 fecal samples from wild rats and mice from Luzon and Mindoro islands were examined. Molecular screening at the ...
Lazenby Billie T - - 2013
Avoidance behaviour can play an important role in structuring ecosystems but can be difficult to uncover and quantify. Remote cameras have great but as yet unrealized potential to uncover patterns arising from predatory, competitive or other interactions that structure animal communities by detecting species that are active at the same ...
Inceboz Tonay - - 2012
We aimed to assess the ability of (131)I-Pyrimethamine scintigraphy to detect the lesions of Toxoplasma gondii infection. An experimental model of toxoplasmosis was developed. The presence of toxoplasmosis was confirmed 60 days after implantation. Pyrimethamine was radioiodinated with I-131. The radioligand was validated by the requisite quality control tests to ...
Hanske Laura - - 2012
Cyanidin 3-glucoside (C3G) is one of the major dietary anthocyanins implicated in the prevention of chronic diseases. To evaluate the impact of human intestinal bacteria on the fate of C3G in the host, we studied the metabolism of C3G in human microbiota-associated (HMA) rats in comparison with germ-free (GF) rats. ...
Lahooti Afsaneh - - 2012
In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of (111)In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to ...
Bylund Johan - - 2012
1. In vitro metabolic profiling and in vitro genotoxicity assessment are important aspects of the drug discovery program as they eliminate harmful compounds from further development. In standard in vitro genotoxicity testing, induced rat liver S9 is used as an exogenous bio-activation system for detecting promutagens. In this study we show ...
Nagl Veronika - - 2012
Deoxynivalenol-3-β-D-glucoside (D3G), a plant metabolite of the Fusarium mycotoxin deoxynivalenol (DON), might be hydrolyzed in the digestive tract of mammals, thus contributing to the total dietary DON exposure of individuals. Yet, D3G has not been considered in regulatory limits set for DON for foodstuffs due to the lack of in ...
Lee Young Sun - - 2012
In this study, the pharmacokinetics of verapamil and its active metabolite norverapamil were evaluated following intravenous and oral administration of 10 mg/kg verapamil to rats with hyperlipidaemia (HL) induced by poloxamer 407 (HL rats). The total area under the plasma concentration time curve (AUC) of verapamil in HL rats following ...
Xu Hai-Yang - - 2012
In this study, we investigated whether two brain regions, the bed nucleus of the stria terminalis (BNST) and the basolateral amygdala (BLA), affected male rats (Rattus norvigicus) ability to innately discriminate between a predator odor (cat urine) and female rat urine. Muscimol, a GABAa receptor agonist, was bilaterally microinjected into ...
Li Jun - - 2012
Curcuminoids are natural food coloring additives with anti-inflammatory, antioxidant, and anticarcinogenic activity, which contain mainly three diarylheptanoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. In this paper, the metabolites of curcuminoids in the feces and urine of rats after oral administration by gavage were investigated. Four new metabolites, 3-hydroxy-[1-(4-hydroxyphenyl)-7-(3-hydroxyphey)] heptane-A (M1), 3-hydroxy-[1-(4-hydroxyphenyl)-7-(3-hydroxyphey)] heptane-B ...
Mathews James M - - 2012
1. The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2, 15, or 150 mg/kg. Clearance of MNA was investigated in male and female rat, mouse, and human hepatocytes. 2. MNA was cleared slowly ...
Oufir Mouhssin - - 2012
The natural product (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolin-2-one (indolinone) was identified some years ago as a nanomolar inhibitor of FcɛRI-receptor dependent mast cell degranulation. To further explore the potential of the compound, we established an UPLC-MS/MS assay for dosage in rat plasma. The method was fully validated according to FDA Guidance for industry. Results ...
Zhang Ya-Zhou - - 2012
Calycosin and calycosin-7-O-β-d-glucoside are two main bioactive isoflavonoids in Astragali Radix. To profile the metabolites of calycosin in rat hepatic 9000×g supernatant incubation system and the metabolites of calycosin-7-O-β-d-glucoside in rat urine, high performance liquid chromatography with diode array detector and combined with electrospray ionization ion trap time-of-flight multistage mass ...
He Chun-Yong - - 2012
ETHNOPHARMACOLOGICAL RELEVANCE: Ligusticum chuanxiong Hort. (Umbelliferae) is widely prescribed for treatment of cardiovascular diseases in China for centuries. One of the major bioactive components in L. chuanxiong is senkyunolide I (SEI), which shows pharmacological activities in anti-migraine and anti-oxidative damage. MATERIALS AND METHODS: The aim of this study was to ...
Xu Xiao-Ping - - 2012
In order to characterize the pharmacokinetics, excretion, and distribution of combretastatin A4 phosphate (CA4P) and its active metabolite, combretastatin A4 (CA4), in rats, a reliable gradient HPLC-based method has been developed and validated. The pharmacokinetic profiles of CA4P and CA4 in rats after CA4P intravenous injection at doses of 0.7, ...
Chen Zhe - - 2012
Over one half the patients with rheumatoid arthritis (RA) are being treated with methotrexate (MTX). Although well proven, the efficacy of MTX varies in individual patients. This study examined the metabolic biomarkers that can be used to predict the therapeutic effect of MTX by using metabolomic analysis. Rats were immunized ...
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