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Ashwell Ken W S KW Department of Anatomy, School of Medical Sciences, The University of New South Wales , Sydney , - - 2014
Abstract Metatherians and monotremes are born in an immature state, followed by prolonged nurturing by maternal lactation. Quantitative analysis of isocortical sections held in the collections at the Museum für Naturkunde, Berlin was used to compare the pace of somatosensory cortex development relative to body size and pallial thickness between ...
McAllister Chris T CT Science and Mathematics Division, Eastern Oklahoma State College, Idabel, Oklahoma, 74745, USA, - - 2014
During July 2011, a single Cordillera striped shrew-rat (Chrotomys whiteheadi) was collected from the Philippines and its faeces examined for coccidian parasites. It harboured an eimerian that we describe here as new. Oocysts of Eimeria macarthuri sp. n. were spheroidal to subspheroidal with a bi-layered wall and measured (length × ...
Scialli Anthony R AR Tetra Tech Sciences, Arlington, - - 2014
Atrazine (ATR), hydroxyatrazine (OH-ATR), and the three chloro metabolites of ATR (deethylatrazine [DEA], deisopropylatrazine [DIA], diaminochlorotriazine [DACT]) were evaluated for developmental effects in rats and rabbits. Three developmental toxicity studies were conducted on ATR in rats (two studies) and rabbits and a developmental toxicity study was conducted in rats for ...
Ellis-Hutchings Robert G RG Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, 48674, USA. Electronic address: - - 2014
High dose gavage administration of ethylene glycol (EG) induces teratogenicity in rodents, but not in rabbits, resulting from saturation of intermediate EG metabolism and glycolic acid (GA) accumulation. In vivo, rat embryos sequester GA 2-4 fold higher than maternal blood, a phenomenon absent in rabbits and proposed not to occur ...
Moya Maria V MV Center for Learning & Memory, The University of Texas at Austin, Austin, Texas, 78712, - - 2014
The medial prefrontal cortex (mPFC) of both rats and rabbits has been shown to support trace eyeblink conditioning, presumably by providing an input to the cerebellum via the pons that bridges the temporal gap between conditioning stimuli. The pons of rats and rabbits, however, shows divergence in gross anatomical organization, ...
Kawamura Satoshi S Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., Konohana-ku, Osaka, - - 2014
S-53482 is an N-phenylimide herbicide and shows a remarkable species difference in developmental toxicity between rats and rabbits. The herbicide produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats, but not in rabbits. Our objective in this study was to investigate differences in developmental ...
Schmidt Tobias - - 2013
trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were ...
Mandel Yossi Y IDF Medical Corps, Ramat Gan, Israel. - - 2013
Trauma is a leading cause of death among young individuals globally and uncontrolled hemorrhage is the leading cause of preventable death. Controlling hemorrhage from a solid organ is often very challenging in military as well as civilian setting. Recent studies demonstrated reversible vasoconstriction and irreversible thrombosis following application of microseconds-long ...
Allais Linda - - 2013
The rabbit is generally the non-rodent species or second species after the rat recommended by the regulatory authorities and is part of the package of regulatory reproductive studies for the detection of potential embryotoxic and/or teratogenic effects of pharmaceuticals, chemicals, food additives, and other compounds, including vaccines (see Chapters 1-7).Its ...
Epps S Alisha SA Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, - - 2012
Although a strong co-morbidity exists clinically between epilepsy and depression, the cause of this co-morbidity remains unknown, and a valid animal model is crucial for the identification of underlying mechanisms and the development of a screening tool for novel therapies. Although some rodent models of epilepsy have been reported to ...
Buteneers Pieter - - 2012
In recent years, an increasing number of studies have investigated the effects of closed-loop anti-epileptic treatments. Most of the current research still is very labour intensive: real-time treatment is manually triggered and conclusions can only be drawn after multiple days of manual review and annotation of the electroencephalogram (EEG). In ...
Vahabzadeh-Hagh Andrew M AM Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, - - 2012
Transcranial magnetic stimulation (TMS) is a well-established clinical protocol with numerous potential therapeutic and diagnostic applications. Yet, much work remains in the elucidation of TMS mechanisms, optimization of protocols, and in development of novel therapeutic applications. As with many technologies, the key to these issues lies in the proper experimentation ...
- - 2012
Due to an oversight the name of an author was published wrong in article entitled "Involvement of rat hippocampal astrocytes in β-amyloid-induced angiogenesis and neuroinflammation" in journal "Current Alzheimer Research, 2010, Vol. 7, no. 7. pp. 591-601." The correct names of authors are given below: Fioravanzo L, Venturini M, Di ...
Baulac Stéphanie - - 2012
Mutations of the leucine-rich glioma-inactivated 1 (LGI1) gene cause an autosomal-dominant partial epilepsy with auditory features also known as autosomal-dominant lateral temporal lobe epilepsy (ADLTE). LGI1 is also the main antigen present in sera and cerebrospinal fluids of patients with limbic encephalitis and seizures, highlighting its importance in a spectrum ...
Alvarado Juan Carlos - - 2012
Auditory brainstem evoked responses (ABR) have been used for decades to assess auditory function. Surprisingly, despite the fact that rats are one of the most widely used experimental models in hearing, there have been no studies that have characterized in detail the normal morphological variations that occur in ABR waves. ...
Celikyurt Ipek Komsuoglu - - 2012
Prepulse inhibition (PPI) is a measurable form of sensorimotor gating. Disruption of PPI reflects the impairment in the neural filtering process of mental functions that are related to the transformation of an external stimuli to a response. Impairment of PPI is reported in neuropsychiatric illnesses such as schizophrenia, Huntington's disease, ...
Vinogradova Lyudmilav - - 2012
Reorganization of seizure networks during epileptogenesis involves cortico-subcortical and interhemispheric interactions. In the audiogenic kindling (AK) model of generalized tonic-clonic seizures, upstream seizure propagation along ascending brainstem-to-forebrain pathways determines progressive intensification of repeated sound-induced convulsions. Full-blown audiogenic seizures are bilaterally symmetric and their repetition results in bisynchronous recruiting the cortex ...
Jensen Ralph J - - 2012
Electronic retinal prostheses are being developed for people who become blind due to loss of photoreceptors from the disease retinitis pigmentosa. Previously, we reported on the responses of RGCs in the P23H rat (a model of retinitis pigmentosa) and the Sprague-Dawley (SD) rat to stimulation with a 400-μm diameter electrode (Jensen ...
Gupta Gaurav - - 2012
BACKGROUND: Viscum album L. is claimed in traditional medical practice, to be useful in the treatment of epilepsy and insomnia in Himachal Pradesh, India. OBJECTIVES: To study the sedative, antiepileptic and antipsychotic effects of aqueous leaf extract of Viscum album L. in mice and rats. MATERIALS AND METHODS: The effect ...
Liu Zhi'an - - 2012
Although studies have shown that excitotoxicity mediated by N-methyl-D-aspartate receptors (NMDARs, NR) plays a prominent role in Alzheimer's disease (AD), the precise expression patterns of NMDARs and their relationship to apoptosis in AD have not been clearly established. In this study, we used Abeta (Aβ) 1-40 and AlCl(3) to establish ...
Wang Li - - 2012
Inositol polyphosphate phosphatase 4 A (INPP4A), a phosphoinositides phosphatase, is highly expressed in the central nervous system and plays a role in glutamate excitotoxicity and cell proliferation. Our aim was to investigate the expression of INPP4A in patients with temporal lobe epilepsy (TLE) and in a rat model of epilepsy. ...
Yamada Koji - - 2012
Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy. The purpose of this study was to investigate whether olopatadine, one of the most efficacious antihistamines, promotes seizures induced by electroshocks in young rats. We investigated the ...
Izdebska Joanna N JN Department of Invertebrate Zoology and Parasitology, University of Gdańsk, 59 Wita Stwosza Street, 80-308 Gdańsk, - - 2012
Demodex ratticola was recorded in the brown rat Rattus norvegicus from northern Poland. It is a skin mite specific to this host, previously recorded only in the Czech Republic. D. ratticola was found at a prevalence 65.0% and mean intensity 12.7 in skin samples taken from the regions of lips, ...
Wang C - - 2012
To study the effects of low-frequency cortical electrical stimulation (CES) on seizures and behaviour in a rat model of epilepsy induced by ferric chloride (FeCl(3)). Rats were randomly assigned into four groups (n = 8 per group): normal healthy rats; saline-treated control rats; FeCl(3)-induced epileptic rats; CES-treated FeCl(3)-induced epileptic rats. ...
Wolfe Jason - - 2011
We know much about how rats use their whiskers to discriminate simple tactile properties, but little about how they are used in natural settings. Here we studied whisker motion during social interactions between rats in order to gain a better understanding of natural whisker use in this model system for ...
Abdanipour Alireza - - 2011
Temporal lobe epilepsy is one of the most common types of epilepsy. Cytotherapy was tried for several neurological disorders. In this investigation, bone marrow stromal cells (BMSCs) were used in order to evaluate the recovery of epileptic rats induced by pilocarpine. The rats were divided into four groups: a negative ...
Langer Melanie - - 2011
Outbred rat strains such as Sprague-Dawley (SD) or Wistar are widely used in epilepsy models, including popular models of temporal lobe epilepsy in which spontaneous recurrent seizures (SRS), hippocampal damage, and behavioral alterations develop after status epilepticus (SE). Such rats are randomly outbred, hence allelic variations can occur across separate ...
Mochizuki Kazuki - - 2011
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, exhibit chronic and slowly progressive hyperglycemia with obesity. In this study, we examined whether dietary supplementation with the α-glucosidase inhibitor miglitol from the preonset stage improves glycemic control and reduces the gene expression of inflammatory cytokines ...
Surina N M - - 2011
We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in ...
Kim Jong-Hoon - - 2011
PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age ...
Roncal-Jimenez Carlos A CA Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80016, USA. - - 2011
Fructose induces metabolic syndrome in rats; but studies have been criticized for using high concentrations of fructose that are not physiologic, for using only pure fructose, and for not controlling for energy intake. We tested the hypothesis that a 40% sucrose diet (containing 20% fructose) might induce features of metabolic ...
Wang Lei L Department of Gastroenterology, the Ninth People's Hospital Affiliated to the School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, - - 2011
To detect the proteomic variabilities of pancreatic intraepithelial neoplasia (PanIN) and pancreatic carcinoma (PC) induced by 7,12-dimethylbenzanthracene (DMBA) in rat models and to identify potential biomarkers. Sixty adult male Sprague Dawley rats were randomized into three groups. The rats had DMBA implanted into their pancreas for one (n = 20) ...
Li Yang - - 2011
In order to investigate how to improve the function and survival of cryopreserved islets, we cocultured cryopreserved thawed rat islets with rat Sertoli cells. After thawing, the islets were divided into the Sertoli cell coculture group and the control group. Using light and transmission electron microscopes, we examined the morphology ...
Carrión Blanca - - 2011
Continuous exposure of the peritoneal membrane to high glucose dialysis solutions can produce functional alterations in this membrane. We studied the toxic effects of high glucose (50 mmol/L and 83 mmol/L) and its reversal by atorvastatin (0.5 - 5 μmol/L) on cultures of rat peritoneal mesothelial cells (PMCs). Rat PMCs ...
Ackroff Karen K Brooklyn College, City University of New York, Brooklyn, NY 11210, USA. - - 2011
High fructose corn syrup (HFCS) has replaced sucrose in many food products, which has prompted research comparing these two sweeteners in rodents. The present study examined the relative palatability of HFCS and sucrose for rats, offering 11% carbohydrate solutions to match the content of common beverages for human consumption. The ...
Elferchichi Miryam - - 2011
Purpose: The aim of this study was to investigate if the metabolic alterations observed after static magnetic field (SMF) exposure participates in the development of a pre-diabetic state. A comparison study using the insulin resistant animal model, the Zucker rat and the SMF-exposed Wistar rat was carried out. Materials and methods: Zucker ...
Rafacho A - - 2011
Long-term dexamethasone therapy may induce peripheral insulin resistance (IR), which in turn elicits increased beta-cell function and proliferation. However, whether such adaptive compensations occur during short-term treatment with dexamethasone is unclear. Here, we compared morphofunctional parameters in endocrine pancreas after short- and long-term dexamethasone administration. Groups of rats received daily ...
Hira Tohru - - 2011
Palatinose (isomaltulose), a slowly digested disaccharide, is used as a non-cariogenic sugar and as a sucrose substitute in several foods. Because of its ability to lower postprandial glycemia, palatinose may be beneficial as a treatment for impaired glucose metabolism. Glucagon-like peptide-1 (GLP-1) improves glycemia via enhancing pancreatic beta-cell functions. The ...
Kummer Kai - - 2011
A main challenge in the therapy of drug dependent individuals is to help them reactivate interest in non-drug-associated activities. We previously developed a rat experimental model based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of social interaction with a gender- and weight-matched male Sprague ...
Myers Kevin P - - 2010
Rats learn to prefer flavors that are followed by postingestive effects of nutrients. This experiment investigated whether the timing of a flavor (specifically, in the first or second half of the meal) influences learning about that flavor. Stronger learning about earlier or later flavors would indicate when the rewarding postingestive ...
Fu Yan Yan - - 2010
Oxidative stress is an important pathogenic factor in diabetes. Bilirubin may serve a cytoprotective function as an anti-oxidant. The Gunn rat lacks the enzyme uridine-diphosphate glucuronosyltransferase that is responsible for conjugation of bilirubin, exhibiting elevation of plasma bilirubin. We examined the effect of hyperbilirubinemia on the pancreatic damage caused by ...
Jung Kyung Hee - - 2011
Acute pancreatitis (AP) has a high mortality rate; repetitive AP induces chronic AP and pancreatic adenocarcinoma. Mesenchymal stem cells (MSCs) have immunoregulatory effects and reduce inflammation. We developed a protocol to isolate human bone marrow-derived clonal MSCs (hcMSCs) from bone marrow aspirate and investigated the effects of these cells in ...
Zhang X P - - 2010
The aim of this study was to compare the protective effects of three traditional Chinese herbal medicines (ligustrazine, kakonein and Panax notoginsenosides) on multiple organs in a rat model of severe acute pancreatitis (SAP) and to explore the underlying mechanisms. The mortality rates in all three treated groups were significantly ...
Wyckhuys Tine - - 2010
Hippocampal deep brain stimulation (DBS) is an experimental therapy for patients with pharmacoresistant temporal lobe epilepsy (TLE). Despite the successful clinical application of DBS, the optimal stimulation parameters are undetermined. We evaluate the efficacy of a new form of DBS, using continuous stimuli with Poisson distributed intervals (Poisson distributed stimulation, ...
Shen Guofu - - 2011
A significant link was previously established between benzodiazepine withdrawal anxiety and a progressive increase in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) potentiation in hippocampal CA1 neurons from rats withdrawn up to 2 days from 1-week oral administration of the benzodiazepine flurazepam (FZP). Despite AMPAR current potentiation, withdrawal anxiety was masked by a ...
Harreby Kristian R - - 2011
Continuous, scheduled vagus nerve stimulation (VNS) is used for the treatment of refractory epilepsy. On-demand VNS, started prior to or at the onset of a seizure may improve the effect of the treatment, however, this requires seizures to be predicted or detected early. This study investigates the possibility of early ...
Jimam Ns - - 2010
The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxan-induced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood glucose concentration of normoglycemic rats treated with oral doses of 1000 and 1500 mg/kg of the extract. ...
Figliuzzi Marina M Department of Biomedical Engineering, Mario Negri Institute for Pharmacological Research, Bergamo, Italy. - - 2010
The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim of the present study was to investigate whether in the Munich Wistar Frömter (MWF) rat, beside a reduction in the number of nephrons, there are also alterations in the number of pancreatic islets ...
Scott Brian W - - 2010
PURPOSE: Racine's classic study suggested that after discharge thresholds were reduced in the primary stimulation site (amygdala) of kindled rats, but that that they were not reduced in secondary (nonstimulated) sites. However, recent reports of neurochemical changes related to excitation and inhibition in nonstimulated sites in kindled brains would be ...
Choi Hui-Chul - - 2010
Selective serotonin reuptake inhibitors (SSRIs) acting on the serotonin (5-HT) receptors may affect γ-aminobutyric acid (GABA)-ergic transmission. The role of 5-HT in the epileptic hippocampus remains controversial since 5-HT has both convulsive and anticonvulsive effects. We investigated the effects of fluoxetine, paroxetine and citalopram on the GABAergic transmission in the ...
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